NISIZAWA Tosiki 西沢俊樹

… Alternative Names

西澤俊樹ニシザワトシキ

NISHIZAWA Toshiki 西澤俊樹

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Researcher Number	00072942
Affiliation (based on the past Project Information) *help	2002: National Institute of Infectious Diseases, Department of Oral Science, Chief Scientist, 口腔科学部, 主任研究員 1998 – 2001: 国立感染症研究所, 口腔科学部, 室長 1999: 国立感染症研究所, 口腔科学部, 齲蝕室長 1994: 国立予防衛生研究所, 口腔科学部, 室長 1992 – 1994: 国立予防衛生研究所, 口腔科学部, 主任研究官 1992: 国立予防衛生研究所, 口腔科学部, 主任研究室 1988 – 1991: 国立予防衛生研究所, 歯科衛生部, 主任研究官
Review Section/Research Field	Principal Investigator Functional basic dentistry Except Principal Investigator Functional basic dentistry / 小児・社会系歯学 / Periodontal dentistry / Morphological basic dentistry / Conservative dentistry
Keywords	Principal Investigator ペプチドワクチン / synthetic peptide / Streptococcus mutans / cell surface protein antigen / dental caries / peptide vaccine / 交叉反応性エピトープ / 抗体誘導能 / コンジェニックマウス / スペーサーアミノ酸 … More / アグレトープ / 多面ペプチドワクチン / 滑面う蝕 / 粘膜免疫 / 鼻腔免疫 / 多価ペプチドワクチン / マルチアグレトープ型ペプチド / ペプチド抗原 / 平滑面う蝕 / グルカン合成抑制効果 / キシロシルフラクトシド / グルカン合成 / グルコシルトランスフェラーゼ / 抗原エピトープ / PAc / MHC拘束性 / う蝕予防 / 水溶性グルカン合成酵素 / 非水溶性グルカン合成酵素 / ヒト口腔内う蝕試験(ICT) / 抗う蝕原性甘味剤 / う蝕 / 口腔内連鎖球菌 / グルコシルトランスフェラ-ゼ / キシロシルフルクトシド(XF) … More Except Principal Investigator う蝕 / Streptococcus mutans / 酸発酵 / Dental caries / ミュータンスレンサ球菌 / PAc / ワクチン / 歯周病 / 代用糖 / キシロシルフルクトシド / Insoluble glucan / Glucosyltransferase / Acid production / Xylosylfructoside / Mutans streptococci / Sweetening / グルコシルトランスフェラ-ゼ / う蝕予防甘味剤 / 抗う蝕原性 / 非水溶性グルカン / グルカン合成酵素 / う蝕原性レンサ球菌 / 甘味剤 / Fluorescence / Calculus / Dental Plaque / Periodontitis / Dental Biofilm / Laser / バイオフィルム / 蛍光 / 歯石 / 歯垢 / バイオフイルム / レーザー / demineralization / artificial mouth system / acid fermentation / dental caaries / mutans streptococci / phosphoryl-oligosaccharides / エナメル質脱灰 / 脱灰 / 人工口腔装置 / リン酸化オリゴ糖 / Food-Materials / Cariogenicity / Intraoral-cariogenicity-test / pH-in-Plaque / Sugar-substitutes / Indwelling-electrde / Dental-caries / Foods / 歯垢微生物 / 代用糖(甘味料) / 内蔵電極法 / 酸産生 / 齲蝕予防 / 口腔内脱灰再石灰化法 / 甘味料 / 食品の齲蝕誘発性の検定 / 代用甘味料 / ウ蝕誘発性 / 食品素材 / 歯垢pH / 口腔内脱灰試験 / 電極内蔵法 / ウ蝕(むし歯) / 食品 / Teflon diffusion apparatus / fluoride / テフロン製容器 / 拡散容器 / 拡散法 / 微量フッ素分析法 / テフロン / 拡散装置 / フッ素 / テフロン微量拡散装置 / フッ化物 / Peptide antigen / B cell epitope / T cell epitope / Passive immunization / ミュ-タンスレンサ球菌 / タンパク質抗原 / う蝕予防 / ペプチド抗原 / B細胞エピトープ / T細胞エピトープ / 受身免疫 / フィブロネクチン / コラーゲン / 細胞外マトリックス / 歯肉線維芽細胞 / 経鼻免疫 / 経口免疫 / 受動免疫 / 能動免疫 / 歯周病原性細菌 / 免疫療法 / グルコシルトランスフェラーゼ / S.mutans / ミュータンス・レンサ球菌 / スクロース Less

Analysis of Destruction Mechanisms of Dental Biofilm by Laser and Its Clinical Application
- Principal Investigator
  
  KOSEKI Takeyoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Tohoku University
  Kyushu Dental College
  National Institute of Infectious Diseases
歯周病の免疫療法に関する研究
- Principal Investigator
  
  岡田宏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Osaka University
Development of preventive method for dental caries by using phosphoryl-oligosaccharides
- Principal Investigator
  
  IMAI Susumu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  National Institute of Infectious Diseases
Development of a peptide-vaccine for prevention of the surface caries.Principal Investigator
- Principal Investigator
  
  NISIZAWA Tosiki
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  National Institute of Infections Diseases
う蝕関連酵素に対する抗う蝕原性代用糖候補キシロシルフルクトシドの阻害機作
- Principal Investigator
  
  今井奨
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  小児・社会系歯学
- Research Institution
  国立予防衛生研究所
う蝕用ペプチドワクチンの開発:万人に有効なペプチド抗原は存在するか?Principal Investigator
- Principal Investigator
  
  西沢俊樹
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  国立予防衛生研究所
Basic research for evaluating caroigenic potential of foods and sugar substitutes.
- Principal Investigator
  
  YAMADA Tadashi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
Development of the passive immunization for prevention of dental caries using B cell epitopes of PAc.
- Principal Investigator
  
  OKAHASHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  National Institute of Health
Development on the fluoride microdiffusion apparatus.
- Principal Investigator
  
  HINOIDE Moriyo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  小児・社会系歯学
- Research Institution
  National Institute of Health
抗う蝕原性糖質(XF)のグルコ-ス転移酵素阻害機作およびう蝕関連酵素に対する影響Principal Investigator
- Principal Investigator
  
  西沢俊樹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  国立予防衛生研究所
ヒト正常歯肉線維芽細胞のコラーゲン代謝の制御に関する研究
- Principal Investigator
  
  今井奨
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  国立予防衛生研究所
グルコース転移酵素の活性を阻害する糖質およびその阻害機作Principal Investigator
- Principal Investigator
  
  西澤俊樹
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  国立予防衛生研究所
Development of sweetening preventive of dental caries by using xylosylfructoside
- Principal Investigator
  
  HINOIDE Moriyo
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  小児・社会系歯学
- Research Institution
  National Institute of Health

All 2005 2004 2003 2001 2000 1999

All Journal Article

[Journal Article] An ingenious design for peptide vaccines.2005
- Author(s)
  Yano A, Onozuka A, Asahi-Ozaki Y, Imai S, Hanada N, Miwa Y, Nisizawa T.
- Journal Title
  
  Vaccine 23
  
  Pages: 2322-2326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] Feasibility of eradication of mutans streptococci from oral cavities.2004
- Author(s)
  Nomura Y, Takeuchi H, Kaneko N, Matin, K, Iguchi R, Toyoshima Y, Kono Y, Ikemi T, Imai S, Nisizawa T, Fukushima K, Hanada N.
- Journal Title
  
  Journal of oral science 46
  
  Pages: 179-183
- NAID
  130000072605
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] Oral streptococci exhibit diverse susceptibility of human b-defensin-2 : Antimicrobial effects of hBD-2 on oral streptococci.2004
- Author(s)
  Nishimura E, Eto A, Kato M, Hashizume S, Imai S, Nisizawa T, Hanada N.
- Journal Title
  
  Current Microbiol. 48
  
  Pages: 85-87
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] RGD motif enhances immunogenicity and adjuvanicity of peptide antigens in intranasal immunization.2003
- Author(s)
  Yano A, Onozuka A, Matin K, Imai S, Hanada N, Nisizawa T.
- Journal Title
  
  Vaccine. 22
  
  Pages: 237-243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] Clinical study of mutans streptococci using 3DS and monoclonal antibodies.2001
- Author(s)
  Takeuchi H, Fukushima K, Senpuku H, Nomura Y, Kaneko N, Yano A, Morita E, Imai S, Nisizawa T, Kono Y, Ikemi T, Toyoshima Y, Hanada N.
- Journal Title
  
  Jpn J.Infect.Dis. 54
  
  Pages: 34-36
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] The effect of amino acid spacers on the antigenicity of dimeric peptide-inducing cross-reacting antibodies to a cell surface protein antigen of Streptococcus mutans.2001
- Author(s)
  Oishi Y, Onozuka A, Kato H, Shimura N, Imai S, Nisizawa T.
- Journal Title
  
  Oral Microbiol Immunol 16
  
  Pages: 40-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] New dental drug delivery system for removing mutans streptococci from the oral cavity : effect on oral microbial flora.2000
- Author(s)
  Takeuchi H, Senpuku H, Matin K, Kaneko N, Yusa N, Yoshikawa E, Ida H, Imai S, Nisizawa T, Abei Y, Kono Y, Ikemi T, Toyoshima Y, Fukushima K, Hanada N.
- Journal Title
  
  Jpn J.Infect.Dis. 53
  
  Pages: 211-212
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11470384
[Journal Article] Inhibitory effect of a self-derived peptide on glucosyltransferase of Streptococcus mutans.Possible novel anticaries measures.1999
- Author(s)
  Eto A, Saido TC, Fukushima K, Tomioka S, Imai S, Nisizawa T, Hanada N.
- Journal Title
  
  J Biol Chem. 274(22)
  
  Pages: 15797-15802
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11470384

1. IMAI Susumu (80072958)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
2. HINOIDE Moriyo (60072906)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OKAHASHI Nobuo (40150180)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SENPUKI Hidenobu (20250186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAMADA Tadashi (50005021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KANEHIRA Takashi (90194935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IIJIMA Yoichi (70094860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUKUBO Takashi (90112804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HOSHINO Etsuro (90124619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOSEKI Takeyoshi (80291128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IWAKURA Makaki (90005067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIHARA Tatsuji (80192251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAESU Yoshinori (60048303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡田宏 (40038865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石川烈 (10014151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 村山洋二 (50029972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 安孫子宜光 (70050086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 奥田克爾 (40085741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 請井繁樹 (50184990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMAMATO Masao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KITAHATA Sumio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NISIZAWA Tosiki 西沢 俊樹

西澤 俊樹 ニシザワ トシキ

NISHIZAWA Toshiki 西澤 俊樹

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Development of a peptide-vaccine for prevention of the surface caries.Principal Investigator

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う蝕用ペプチドワクチンの開発:万人に有効なペプチド抗原は存在するか?Principal Investigator

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抗う蝕原性糖質(XF)のグルコ-ス転移酵素阻害機作およびう蝕関連酵素に対する影響Principal Investigator

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グルコース転移酵素の活性を阻害する糖質およびその阻害機作Principal Investigator

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[Journal Article] An ingenious design for peptide vaccines.2005

Author(s)

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Description

Data Source

NISIZAWA Tosiki 西沢俊樹

西澤俊樹ニシザワトシキ

NISHIZAWA Toshiki 西澤俊樹