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OKUMURA Yutaka  奥村 寛

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… Alternative Names

奥村 寛  オクムラ ユタカ

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Researcher Number 00073130
Other IDs
Affiliation (based on the past Project Information) *help 2003 – 2005: Nagasaki University, Graduated School of Biochemical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授
2002: 長崎大学, 医学部, 助手
1988 – 2002: 長崎大学, 医学部, 教授
1992: 長崎大, 医・後障研, 教授
1992: Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 教授
1992: 長崎大学, 医学部原爆資料センター, 教授
1986: 長崎大, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Radiation science / Radiation science
Except Principal Investigator
Biological Sciences / Radiation science / 環境影響評価(含放射線生物学) / Risk sciences of radiation/Chemicals / 環境生理学(含体力医学・栄養生理学) / 医学一般
Keywords
Principal Investigator
RBE / 熱耐性 / 癌治療 / ハイパーサーミア / p53 / ERK / FAK / scid cells / DNA-PK activity / DNA double strand breaks … More / radiosensitivity / heavy ion particles / DNA-PK活性 / DNA二重鎖切断 / 重粒子線 / 放射線感受性 / scid細胞 / 放射線照射 / 細胞致死 / 温熱処理 / laminin / integrin / X-ray / metastasis / cell mobility / P53 / 神経膠芽腫細胞 / 細胞外マトリックス / 癌転移 / ラミニン / インテグリン / X線 / がん転移 / 細胞運動性 / DNA二重鎖 / DNAニ重鎖切断 / NIH3T3 Cells / Thermosensitivity / Oncogene / NIH3T3細胞 / 熱感受性 / 癌遺伝子 / 温熱増感効果 / 加熱処理 / 温熱療法 / 化学療法 / 体温調節 / ミトコンドリア … More
Except Principal Investigator
p53 / DNA-PK / 放射線感受性 / アポトーシス / 放射線耐性 / 癌治療 / 放射線 / 温熱感受性 / Ku70 / 遺伝子導入 / 温熱療法 / 制癌剤 / スクリーニング / 変異部位 / HSP72 / XRCC / MTF-1 / ATM / HSC73 / Ku80 / 熱ショック蛋白質 / 温熱処理 / 80 / signal transduction / シグナル伝達 / accelerated aging / 放射線治療 / DNA修復 / cell cycle / DNA repair / radiation / thyroid / 甲状腺がん / MDM2 / 細胞周期 / 甲状腺 / phosphorylation / radiation response / crosstalk / environmental stress / 環境ストレ / リン酸化 / 放射線応答 / クロストーク / 環境ストレス / Heat shock Protein / Recovery of hea-inactivation / Heat shock protein / 熱失活の回復 / Heat treatment / DNA double strand break / X線 / DNA二本鎖切断の修復 / DNA-PK活性 / DNA二本鎖切断 / transduction / apoptosis / radio-sensitivity / mutation / SaOS-2 / G1停止 / Saos2 / シグナルトランスダクション / 突然変異 / heat shock protein(HSP) / IL-1alpha beta / Bombesin / neurotensin / cytokine / neuro-peptides / thermotolerance / Thermosensitivity / SDS-PAGE,Western,Northan blotting / 体温調節機序 / 寒冷・暑熱適応機序 / 発熱・解熱 / 温熱細胞性免疫 / 熱感受性 / 熱耐性 / 温度修飾因子 / 熱ショック蛋白 / インターロイキン1αβ / ボンベシン / ニューロテンシン / サイトカイン / ニューロ・ペプタイド / 温熱耐性 / senescence accelerated mouse / time series changes / serum components / radiation-induced aging / SAM / 時系列 / 線形モデル / 加齢 / 老化促進モデルマウス / 時系列変化 / 血清成分 / 放射線加齢 / Saos-2 / リン酸化・脱リン酸化 / DNA・PK / 先行指標 / 感受性修飾 / 細胞死(アポトーシス) / 放射線誘導タンパク / NBS1 / 先行指導 / P53 / 遺伝子マッピング / アタキシアーテランジェクタシア / scidマウス / ヒートショックタンパク質 / 癌抑制遺伝子 / 癌遺伝子 / 癌細胞 / 放射線抵抗性DNA合成 / 染色体移入 / 11番染色体 / 毛細血管拡張性運動失調症 / 21番染色体の過剰 / RFLP / 染色体異型 / 変異遺伝子の量的効果 / がん関連遺伝子 / ダイソミー性ホモ接合性 / 発生機構 / 一過性骨髄異常増殖症 Less
  • Research Projects

    (27 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (37 People)
  •  Study of Involvement of DNA Repair in Radiation Induced Thyroid Cancer

    • Principal Investigator
      ASHIZAWA Kiyoto
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Radiation Effects Research Foundation
  •  Effect of X-ray irradiation on tumor metastasisPrincipal Investigator

    • Principal Investigator
      MATSUDA Naoki, 奥村 寛
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  各種変異p53遺伝子導入細胞のマイクロプレートによる放射線・制癌剤感受性の測定

    • Principal Investigator
      岡市 協生
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Crosstalk of signal transduction of p53 by various stress from environments

    • Principal Investigator
      OKAICHI Kumio
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Nagasaki University
  •  各種変異p53遺伝子導入細胞による放射線治療と制癌剤のスクリーニングシステム

    • Principal Investigator
      岡市 協生
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Role of heat shock protein (HSP) for the recovery of heat-inactivated DNA-PK

    • Principal Investigator
      MAKOTO Ihara
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  各種変異p53遺伝子導入細胞による放射線治療と制癌剤のスクリーニングシステム

    • Principal Investigator
      岡市 協生
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Radiosensitivity of Scid Cells Deficient in Repair of DNA Damages Induced by High LET IrradiationPrincipal Investigator

    • Principal Investigator
      OKUMURA Yutaka
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  放射線感受性予測の基礎研究

    • Principal Investigator
      鈴木 紀夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  p53の変異部位に対応した放射線による癌治療法の開発

    • Principal Investigator
      岡市 協生
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagasaki University
  •  Relationship between DNA double strand break repair and DNA-PK activity

    • Principal Investigator
      IHARA Makoto
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  p53の変異部位に対応した放射線による癌治療法の開発

    • Principal Investigator
      OKAICHI Kumio
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagasaki University
  •  Radiosensitivity of scid cells for heavy ion particlesPrincipal Investigator

    • Principal Investigator
      OKUMURA Yutaka
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      NAGASAKI UNIVERSITY
  •  The changes of radio-sensitivity and signal transduction by mutation in p53

    • Principal Investigator
      OKAICHI Kumio
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Nagasaki University
  •  癌関連遺伝子を標的とする遺伝操作による温熱感受性の制御

    • Principal Investigator
      大西 武雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nara Medical University
  •  Analysis of Thermotolerance of Cancer by Introduction of OncogegesPrincipal Investigator

    • Principal Investigator
      OKUMURA Yutaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  癌関連遺伝子からみた温熱療法抵抗性癌の細胞特性

    • Principal Investigator
      大西 武雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nara Medical University
  •  癌関連遺伝子からみた温熱療法抵抗性癌の細胞特性

    • Principal Investigator
      大西 武雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nara Medical University
  •  癌関連遺伝子からみた温熱抵抗性癌の細胞持性

    • Principal Investigator
      大西 武雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nara Medical University
  •  V(D)Jリコンビネース欠損突然変異を用いたDNA修復機序の解析

    • Principal Investigator
      小松 賢志
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University
  •  Research project on the varient modification of thermosensitivity in the

    • Principal Investigator
      KOSAKA Mitsuo
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      環境生理学(含体力医学・栄養生理学)
    • Research Institution
      Institute of Tropical Medicine, Nagasaki University
  •  Study on quantification of radiation-induced aging by linear model

    • Principal Investigator
      KONDO Hisayoshi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医学一般
    • Research Institution
      Nagasaki University
  •  DNA修復能力と毛細血管拡張性運動失調症(AT)形質発現の解析

    • Principal Investigator
      小松 賢志
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University
  •  一過性骨髄異常増殖症(TAM)の発生機構

    • Principal Investigator
      新川 詔夫
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University
  •  動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator

    • Principal Investigator
      奥村 寛
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University
  •  動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator

    • Principal Investigator
      奥村 寛
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University
  •  動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator

    • Principal Investigator
      奥村 寛
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagasaki University

All 2006 2004 2003 2002

All Journal Article

  • [Journal Article] Sucralfate Protects Intestinal Epithelial Cells From Radiation-Induced Apoptosis in Rats.2006

    • Author(s)
      Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K, Ishii, K., Wen, CY, Fukuda, E., Nakayama, T., Nakashima, M., Okumura, Y., Sekine, I.
    • Journal Title

      J.Radiat.Res. 47

      Pages: 1-8

    • NAID

      110004701145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] 癌細胞で見つかる各種変異p53シグナルの放射線感受性への関与2006

    • Author(s)
      岡市協生, 井手美和, 奥村 寛
    • Journal Title

      広島医学 印刷中

    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] Hypergravity induces phosphorylation of p53 at serine 15 but not expression of p53-downstream genes.2004

    • Author(s)
      Okaichi, K, Ide, M., Usui, A., Okumura, Y.
    • Journal Title

      J.Radiat.Res. 45

      Pages: 399-403

    • NAID

      110004041041

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] Radiation sensitivity and mutation position of p53.2003

    • Author(s)
      Okaichi, K., Ide, M., Okumura, Y.
    • Journal Title

      Radiation and Humankind, Elsevier Science,(Shibata, Y., Yamashita, S., Watanabe, M., Tominaga, M.(eds))

      Pages: 239-243

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] Low dose of wortmannin reduces radiosensitivity of cells.2002

    • Author(s)
      Okaichi, K., Suzuki, K., Morita, N., Ikeda, M., Matsuda, N., Takahashi, H., Watanabe M., Okumura, Y.
    • Journal Title

      Radiation and Homeostasis, Elsevier Science (Sugahara, T., Nikaido, O., Niwa, O.(eds))

      Pages: 359-362

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway.2002

    • Author(s)
      Okaichi, K., Suzuki, K., Morita, N., Ikeda, M., Takahashi, H., Matsuda, N., Watanabe M., Okumura, Y.
    • Journal Title

      Oncol.Rep. 9

      Pages: 859-862

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • [Journal Article] Hypergravity modified the signal transduction of ionizing radiation through p53.2002

    • Author(s)
      Okaichi, K., Usui, A., Ohnishi, T., Okumura, Y.
    • Journal Title

      J.Radiat.Res. 43

    • NAID

      110002328993

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380255
  • 1.  IHARA Makoto (60175213)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  OKAICHI Kumio (80124874)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 7 results
  • 3.  KANO Eiichi (70065910)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  大西 武雄 (60094554)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  鈴木 紀夫 (10010050)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  KOSAKA Mitsuo (30079983)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  小松 賢志 (80124577)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  渡辺 正己 (20111768)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  川崎 祥二 (20034952)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  田中 紀元 (20079932)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  SIMASAKI Tatsuya (60264248)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MATSUDA Naoki (00304973)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  田中 敬正 (40131445)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  中村 弥
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  KONDO Hisayoshi (00170431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MINE Mariko (00108292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  ISEKI Masachika (50176252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KISHIKAWA Masao (80112374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NAGASAKA Tetsuo (80023646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  IRIKI Masami (90072967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KUROSHIMA Akihiro (90002774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TAKESHITA Satoshi (20295083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MORITA Naoko (90380972)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ASHIZAWA Kiyoto (10304932)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NANBA Hiroyuki (80237635)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  新川 詔夫 (00111170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  陣野 吉廣 (20179097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  辻 芳郎 (30039812)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  児玉 靖司 (00195744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  上田 公介 (20128648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  豊島 宗厚 (10155533)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  渡辺 直樹 (10158644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  平岡 真寛 (70173218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  小川 恭弘 (90152397)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  森 弘行 (30128227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  山下 俊一 (30200679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  中村 彌
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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