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HORIUCHI Noboru  堀内 登

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堀内 登  ホリウチ ノボル

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Researcher Number 00107294
Other IDs
Affiliation (based on the past Project Information) *help 2011: 奥羽大学, 歯学部, 教授
2009: 奥羽大学, 歯学部, 教授
2003 – 2007: 奥羽大学, 歯学部, 教授
1998 – 2000: 奥羽大学, 歯学部, 教授
1991 – 1995: 奥羽大学, 歯学部, 教授
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Surgical dentistry / Conservative dentistry / Applied health science
Keywords
Principal Investigator
骨吸収 / PTHrP / Mineralization / prenylation / BMP-2 / MC3T3-E1 cells / Statins / 1,25(OH)_2D_3 / PTH_rP / 遺伝子発現 … More / カルシウム調節ホルモン / 癌 / Adipocyte / Statin / Chondrocyte / Osteoblast / Lipid / Cell and Tissue / Differentiation / Dentistry / 細胞・組織 / 発生・分化 / 脂質 / 再生医学 / 細胞、組織 / 発生、分化 / 歯学 / P13 kinase / Vascular endotherial growth factor (VEGF) / mineralization / hypoxia responsive elements (HRE) / vascular endothelial growth factor (VEGF) / statins / Prenylation / PI3 kinase / Vascular endotherial growth factor(VEGF) / Transcriptional regulation / Vitamin D receptor / 24-hydroxylase / 1a-hydroxylase / Glucocorticoid / Osteoporosis / 転写調節 / ビタミンD受容体 / 24-水酸化酵素 / 1α-水酸化酵素 / グルココルチコイド / 骨粗鬆症 / Parathyroid hormone receptor / 1alpha, 25-dihydroxyvitamin D_3 / Gene expression / Vitamin D-24-hydroxylase / Hypercalcemia / Tumor marker / Oral cancer / 増殖因子 / 腫瘍マーカー / 細胞分化 / 高カルシウム血症 / 癌診断 / 口腔癌 / 口腔癌細胞株 / PTH / 250HD_3-24水酸化酵素 / 歯周病 / 250HD_3ー24OHase / 腎 / PTHrP阻害剤 … More
Except Principal Investigator
promoter / transcriptional factor / osteoblast / PTHrP receptor / PTH / gel mobility shift assay / PTHrP / initiator / siRNA / oral cancer / south western / PTHrP recetor / Akt / PI3K / 分化制御 / 再生 / セメント芽細胞 / MTA / Rho / 骨芽細胞 / メバロン酸 / 石灰化 / スタチン / MTAセメント / 免疫学 / 薬学 / 歯学 / 臨床 Less
  • Research Projects

    (11 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (16 People)
  •  口腔の状態から消化管・免疫系の疾患を探る

    • Principal Investigator
      林 茂寛
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied health science
    • Research Institution
      Ohu University
  •  Regenerative effects of statin and MTA on teeth and periodontal tissue.

    • Principal Investigator
      MAEDA Toyonobu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Conservative dentistry
    • Research Institution
      Ohu University
  •  Elucidation of Regulatory Mechanisms of Osteoblastic and Chondrocytic Differentiation by StatinsPrincipal Investigator

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Analysis of transcription enhancing factor for PTH receptor that controls bone metabolism

    • Principal Investigator
      KAWANE Tetsuya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Mechanism of osteoblast differantiation by statins via stimulation of VEGF gene transcriptionPrincipal Investigator

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Identification of transcription enhancing fator for PTH receptor and analysis it's mechanism at jaw bone resorption site by oral cancer

    • Principal Investigator
      KAWANE Tesuya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Ohu University
  •  Disorder of vitamin D metabolism in steroid-induced osteoporosisPrincipal Investigator

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  口腔粘膜上皮細胞の分化とPTH_rP遺伝子の発現Principal Investigator

    • Principal Investigator
      堀内 登
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Parathyroid hormone-related protein mRNA expression and oral cancer progressionPrincipal Investigator

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  骨吸収促進因子(PTHrP)の細胞内情報伝達機構の解明Principal Investigator

    • Principal Investigator
      堀内 登
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  癌細胞より分泌される骨吸収促進因子(PTHrP)の作用機構Principal Investigator

    • Principal Investigator
      堀内 登
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University

All 2010 2009 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α, 25-dihydroxyvitamin D_3 synthesis in leptin-deficient ob/ob mice2010

    • Author(s)
      Tsuji K, Maeda T, Kawane T, Matsunuam A, Horiuchi N
    • Journal Title

      J Bone Mineral Research (掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650182
  • [Journal Article] Dexamethasone suppresses parathyroid hormone-related protein expression by human oral squemous carcinoma cells (HSC-3)2010

    • Author(s)
      Abe M, Horiuchi N
    • Journal Title

      J Oral Biosciences 52

      Pages: 51-59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650182
  • [Journal Article] Leptin stimulates fibroblast growth factor23expression in bone and suppresses renal 1alpha, 25-dihydroxyvitamin D3 synthesis in leptin-deficient mice2010

    • Author(s)
      Tsuji K, Maeda T, Kawane T, Matsunuma A, Horiuchi N
    • Journal Title

      J Bone Miner Res

      Pages: 1711-1723

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791862
  • [Journal Article] The proteasome inhibitors epoximicin and MG262 suppress urokinase-tyep plasminogen activator expression by human oral squemous carcinoma cells (HSC-3)2009

    • Author(s)
      Abe M, Horiuchi N
    • Journal Title

      奥羽大学歯学誌 36

      Pages: 139-147

    • Data Source
      KAKENHI-PROJECT-21650182
  • [Journal Article] Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation2009

    • Author(s)
      Maeda T, Horiuchi N
    • Journal Title

      J Biochem

      Pages: 771-781

    • NAID

      10025187027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791862
  • [Journal Article] Simvastatin suppresses leptin expression in 3T3-Li adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.2009

    • Author(s)
      Maeda T, Horiuchi N
    • Journal Title

      J Biochemistry 145

      Pages: 771-781

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650182
  • [Journal Article] Up-regulation of PTH receptor mRNA expression by dexamethasone in UMR-106 osteoblast-like cells2007

    • Author(s)
      Nobutaka, Haramoto, Tetssya, Kawane, Noboru, Horiuchi
    • Journal Title

      Oral Diseases 13-1

      Pages: 23-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] attenuates gene expression for renal 25-hydroxyvitamin D_3-1α-hydroxylase in mice via the long form of the leptin receptor2007

    • Author(s)
      Ayako, Matsunuma, Noboru, Horiuchi, Leptin
    • Journal Title

      Archives of Biochemistry and Biophysics 463-1

      Pages: 118-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] Effect of leptin on regulation of renal 25-hydroxyvitamin D_3 metabolism and maintenance of calcium homeostasis2007

    • Author(s)
      Ayako, Matsunuma, Noboru, Horiuchi
    • Journal Title

      Journal of Oral Biosciences 49-2

      Pages: 97-104

    • NAID

      10027102463

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] Statins and bone metabolism2006

    • Author(s)
      Noboru Horiuchi
    • Journal Title

      Oral Diseases 12・2

      Pages: 85-101

    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] Statins and bone metabolism2006

    • Author(s)
      Noboru, Horiuchi, Toyonobu, Maeda
    • Journal Title

      Oral Diseases 12-2

      Pages: 85-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I2005

    • Author(s)
      Tetsuya, Kawane, Junnsei, Mimura, Yoshiaki, Fujii-Kuriyama, Noboru, Horiuchi
    • Journal Title

      Archives of Biochemistry and Biophysics 439-1

      Pages: 61-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592045
  • [Journal Article] Identification of the promoter region of the parathyroid Hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I.2005

    • Author(s)
      Tetsuya Kawane, Junsei Mimura, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
    • Journal Title

      Archives of Biochemistry and Biophysics in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Effect of leptin on renal 1 1α-hydroxylase expression in mice.2004

    • Author(s)
      Noboru Horiuchi
    • Journal Title

      Proceedings of 12th International Congress of Endocrinology

      Pages: 1153-1157

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Atorvastatin enhances hone density in ovariectomized rats given 17j3-estradiol or human parathyroid hormone (1-34).2004

    • Author(s)
      Tetsuya Kawane, Shinichi Terashima, Izuru Kurahashi, Toru Yanagawa, Hiroshi Yoshida, Noboru Horiuchi
    • Journal Title

      Endocrine 24-2

      Pages: 121-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Suppression of parathyroid hormone-related protein expression by all trans-retinoic acid in human oral squamous carcinoma cells (HSC-3).2004

    • Author(s)
      Masatoshi Abe, Nobutaka Haramoto, Hidefumi Itoh, Noboru Horiuchi.
    • Journal Title

      Journal of Oral Biosciences 46-6

      Pages: 550-557

    • NAID

      110003166657

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells.2004

    • Author(s)
      Toyonobu Maeda, Ayako Matsunuma, Izuru Kurahashi, Toru Yanagawa, Hiroshi Yoshida, Noboru Horiuchi
    • Journal Title

      Journal of Cellular Biochemistry 92-3

      Pages: 458-471

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Effect of leptin on renal lα-chydroxylase expression in mice.2004

    • Author(s)
      Noboru Horiuchi, Ayako Matsunuma, Toyonobu Maeda, Masatoshi Abe, Testuya Kawane
    • Journal Title

      Proceedings of 12th International Congress of Endocrinology.

      Pages: 1153-1157

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Leptin corrects increased gene expression of renal 25-hydroxyvitamin D_3- lα-hydroxylase and -24-hydroxylase in leptin- deficient, ob/ob mice.2004

    • Author(s)
      Ayako Matsunuma, Tetsuya Kawane, Toyonobu Maeda, Setsuo Hamada, Noboru Horiuchi
    • Journal Title

      Endocrinology 145-3

      Pages: 1367-1375

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Effect of leptin on renal 1α-hydroxylase expression in mice.2004

    • Author(s)
      Noboru Horiuchi
    • Journal Title

      Proceedings of 12th International Congress of Endocrinology

      Pages: 1153-1157

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Effect of leptin on renal 1α-hydroxylase expression in mice.2004

    • Author(s)
      Noboru Horiuchi
    • Journal Title

      Proceedings of 12th International Congress of Endocrinology.

      Pages: 1153-1157

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.2003

    • Author(s)
      Toyonobu Maeda, Tetsuya Kawane, Noboru Horiuchi
    • Journal Title

      Endocrinology 144-2

      Pages: 681-692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein reeptor gene expression in UMR-106 osteoblast-like cells via a 3', 5'-cyclic adenosine monophosphate- dependent, protein kinase A-independent pathway.2003

    • Author(s)
      Tetsuya Kawane, Junsei Mimura, Toru Yanagawa, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
    • Journal Title

      Journal of Endocrinology 178

      Pages: 247-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010

    • Author(s)
      堀内登、辻潔美、前田豊点、松沼礼子, 川根徹也
    • Organizer
      第31回東北骨代謝研究会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21650182
  • [Presentation] ST2細胞においてSimvastatinは骨分化を促進し脂肪分化を抑制する2010

    • Author(s)
      前田豊信, 堀内登, 加藤靖正
    • Organizer
      日本結合組織学会
    • Data Source
      KAKENHI-PROJECT-21791862
  • [Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010

    • Author(s)
      堀内登, 前田豊信
    • Organizer
      第31回東北骨代謝研究会
    • Data Source
      KAKENHI-PROJECT-21791862
  • [Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010

    • Author(s)
      堀内登
    • Organizer
      第31回東北骨代謝研究会
    • Place of Presentation
      江陽グランドホテル(仙台市)
    • Year and Date
      2010-02-06
    • Data Source
      KAKENHI-PROJECT-21791862
  • [Presentation] スタチンによるレプチン合成抑制機構2009

    • Author(s)
      前田豊信, 川根徹也, 阿部匡聡, 堀内登
    • Organizer
      日本生化学会東北支部第75回例会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-09
    • Data Source
      KAKENHI-PROJECT-21650182
  • [Presentation] スタチンによるレプチンの合成抑制機構2009

    • Author(s)
      前田豊信, 堀内登
    • Organizer
      日本生化学会東北支部第75回例会
    • Data Source
      KAKENHI-PROJECT-21791862
  • 1.  KAWANE Tetsuya (00265208)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 2.  AKENO Nagako (30231856)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  西勝 祥子 (30170484)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  ABE Masatoshi (10254872)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  MAEDA Toyonobu (10382756)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 6.  MATSUNUMA Ayako (30296040)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 7.  KATO Yasumasa (50214408)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  KIMURA Yuichi (60211877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OHNO Tomoya (50094941)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  YANAGAWA Tohru (10312852)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KURAHASHI Izuni (40337259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  木村 早苗 (10245011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  林 茂寛 (50110565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  春日井 昇平 (70161049)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  辻 典子 (30343990)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  OHKAWA Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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