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KIMURA Hiroshi  木村 博

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… Alternative Names

木村 博  キムラ ヒロシ

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Researcher Number 00110560
Other IDs
Affiliation (Current) 2020: 滋賀医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2013: 滋賀医科大学, 医学部, 名誉教授
2011 – 2013: 滋賀医科大学, 医学部, 教授
1996 – 2007: School of Medicine, Shiga University of Medical Science, Full Professor, 医学部, 教授
1995 – 1996: 滋賀医科大学, 助教授
1995: 滋賀医科大学, 医学部, 助教授
1987 – 1989: 滋賀医科大学, 助教授
1986: 滋賀医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Radiation science / 環境影響評価(含放射線生物学)
Except Principal Investigator
Laboratory animal science / 環境影響評価(含放射線生物学) / Human genetics / Biological Sciences / Pathological medical chemistry
Keywords
Principal Investigator
培養細胞突然変異 / DNA塩基配列 / 放射線治療 / 抗がん剤治療 / PCR技術 / hprt遺伝子 / DNA塩基配列変化 / インビボ突然変異 / マルチプレックスPCR / RT-PCR … More / mutagenesis / radiotherapy / polymerase chain reaction / chemotherapy / hprt locus / DNA-sequencing / 組織の繊維化 / X線影響 / アポトーシス誘導 / p53がん抑制遺伝子 / DNA2本鎖切断 / DNA依存性タンパク質リン酸化酵素 / 抗がん剤、SN-38 / Fibrosis / X-ray effect / Apoptosis induction / p53 tumor suppressor / double strand breaks / DNA-dependent protein kinase / ヒドラ / 水環境汚染 / 内分泌撹乱物質 / ビスフェノールA / 精子形成 / 卵形成 / 出芽 / hydra / water polution / endocrine disruptor / bisphenol A / testis formation / egg formation / budding … More
Except Principal Investigator
MHC / 突然変異スペクトル / シャトルベクター / HPRT遺伝子 / 遺伝子治療 / インスリン / 糖尿病 / superoxide dismutase / メダカ / サルES細胞 / GFP / ES細胞 / siRNA / TrpーP2 / 変異原特異性 / DNA修復 / PCR / HPRT^ー遺伝子 / ミユ-テーター癌遺伝子 / ミスマッチ修復 / hMLH1 / ゲノム不安定性 / 遺伝要因 / ミスマッチ修復遺伝子 / 遺伝性非ポリポ-シス大腸癌 / ゲノム不安定性機構 / 突然変異のスペクトル / ミューテーター活性 / 膵島 / 糖尿 / 再生医療 / 国際情報交換 / アメリカ合衆国 / 難治性がん / 放射線治療 / マイトマイシンC / 潜在性致死損傷の回復 / cAMP / クロマン構造 / ヒストンの修飾 / 架橋剤 / 6TG抵抗性変異 / がん原物質誘発変異 / HPRTcDNA遺伝子 / Trp-P_2誘発変異 / PCR法 / ラドン / ラドン娘核種 / ラドン吸入装置 / ラツト / 肺線維芽細胞 / 微小核 / 生物学的影響 / ラット / 突然変異 / 肺繊維芽細胞 / 気管上皮細胞 / DNA配列 / radon / radon progeny / radon exposure system / rats / lung fibroblasts / micronuclei / biological effects / 環境評価 / ゲノム構造 / リガーゼル / 毒性評価 / 補体系 / 自然免疫 / RNAi / 免疫系 / リガーゼIV / 補体 / 化学物質 / Medaka / Environmental assessment / Genome structure / DNA ligase / Toxicity test / Complement / Innate immunity / BACコンテイグ / 多型 / 進化 / 近交系 / 抗原提示 / 塩基配列決定 / BAC / 塩基配列 / ゲノム進化 / 連鎖 / BAC contig / Polymorphism / Evolution / Inhred Strain / 遺伝子改変 / 核移植 / 遺伝子導入 / 多能性 / 分化 / monkey ES cell / genetic engineering / nuclear transfer / EG細胞(embryonic germ cell) / 始原生殖細胞 / カニクイザル / EG細胞(embroyonic germ cell) / embryonic germ cell / primordial germ cell / monkey / embryonic stem cell / RNA干渉法 / ノックアウト / ノックダウン / ARL / RNA interference / knock out / 合併症 / 糖毒性 / diabetic complication / bone marrow / diabetes mellitus / insulin / TNF-α / proinsulin / gene therapy Less
  • Research Projects

    (17 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (26 People)
  •  Reproduction of pancreatic islet in the pancreas by gene therapy

    • Principal Investigator
      KOJIMA HIDETO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Shiga University of Medical Science
  •  Identification of a novel therapeutic target that produces irreversible diabeticg lucotoxicky

    • Principal Investigator
      KOJIMA Hideto
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shiga University of Medical Science
  •  Establishment of embryonic gem cells and their differentiation into germ cells.

    • Principal Investigator
      TORII Ryuzo
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Shiga University of medical science
  •  Development of stage-specific knockout in mammals using RNA interference

    • Principal Investigator
      TAKADA Tatsuyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Shiga university of medical science
  •  Application of genetic engineering using ES cells in macaca.

    • Principal Investigator
      TAKADA Tatsuyuki
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory animal science
    • Research Institution
      Shiga university of medical science, Research center for animal life science
  •  Assessment using hydra of endocrine disruptors contaminated in freshwater environmentPrincipal Investigator

    • Principal Investigator
      KIMURA Hiroshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Shiga University of Medical Science
  •  Evolutaionary mechanism for the adaptive immune system as revealed by the structural analysis of the medaka major histocompatibility complex

    • Principal Investigator
      NONAKA Masaru
    • Project Period (FY)
      1999 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of medaka models for comprehensive assessment of environmental factors

    • Principal Investigator
      NONAKA Masaru
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      University of Tokyo
  •  Radiation-induced apoptosis in DNA-double strand break repair deficient cells and its relation to radiation-induced fibrosisPrincipal Investigator

    • Principal Investigator
      KIMURA Hiroshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Shiga University of Medical Science
  •  ミューテーター癌遺伝子をモデルとした環境変異源の発癌リスクと遺伝要因

    • Principal Investigator
      加藤 武司
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  ミューテーター癌遺伝子をモデルとした環境変異源の発癌リスクと遺伝要因

    • Principal Investigator
      加藤 武司
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Experimental analysis of lung cancer induced by radon exposure and smoking

    • Principal Investigator
      IKEBUCHI Makoto
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Shiga University of Medical Science
  •  Sequence analysis of X ray-induced and anticancer drug-induced mutations in cultured mammalian cells and peripheral blood lymphocytesPrincipal Investigator

    • Principal Investigator
      KIMURA Hiroshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Shiga University of Medical Science
  •  がん原物質によるDNA損傷、修復と誘発変異特異性のシャトルベクターによる解析

    • Principal Investigator
      加藤 武司
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  がん原物質によるDNA損傷、修復と誘発突然変異特異性のシャトルベクターによる解析

    • Principal Investigator
      加藤 武司
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  がん原物質によるDNA損傷, 修復と誘発変異特異性のシャトルベクターによる解析

    • Principal Investigator
      加藤 武司
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  修復機構の制御によるがん細胞の薬剤、放射線感受性の修飾

    • Principal Investigator
      青山 喬
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Shiga University of Medical Science

All 2013 2012 2008 2007 2006

All Journal Article Presentation Book

  • [Book] 糖尿病学の進歩20072007

    • Author(s)
      小島秀人、藤宮峯子、柏木厚典、木村博
    • Total Pages
      6
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Book] 糖尿病学20072007

    • Author(s)
      小島秀人、寺島智也、藤宮峯子、柏木厚典、木村博
    • Total Pages
      7
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] 糖尿病合併症を誘導する異常骨髄細胞の同定と新規治療薬の開発2013

    • Author(s)
      小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
    • Journal Title

      滋賀貴台雑誌

      Volume: 26巻

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590378
  • [Journal Article] 糖尿病合併症を誘導する異常骨髄幹細胞の同定と新規治療薬の開発2013

    • Author(s)
      小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
    • Journal Title

      滋賀医大雑誌

      Volume: 26

    • Data Source
      KAKENHI-PROJECT-23590378
  • [Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013

    • Author(s)
      H Urabe, H Kojima, L Chan, T Terashima, N Ogawa, M Katagi, K Fujino, A Kumagai, H Kawai, A Asakawa, A Inui, H Yasuda, Y Eguchi, K Oka, H Maegawa, A kashiwagi, H Kimura
    • Journal Title

      Nat Commun

      Volume: 4 Pages: 1526-1526

    • DOI

      10.1038/ncomms2536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590378, KAKENHI-PROJECT-23790988, KAKENHI-PROJECT-24659986
  • [Journal Article] Isolation of specific peptides that home to dorsal root ganglion neuronsin mice2008

    • Author(s)
      Oi J, Terashima T, Kojima H, Fujimia M, Maeda K, Arai R, Chan L, Yasuda H, Kashiwagi A, Kimura H
    • Journal Title

      Neuroscience Letters 434

      Pages: 266-272

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] Isolation of specific peptides that home to dorsal root ganglion neurons in mice2008

    • Author(s)
      Oi, J., Terashima, T., Kojima, H., Fujimia, M., Maeda, K., Arai, R., Chan, L., Yasuda, H., Kashiwagi, A., Kimura, H
    • Journal Title

      Neuroscience Letters 434

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] 膵および膵外におけるNgn3とNeuroD1の発現調節と機能2008

    • Author(s)
      小島秀人、木村博
    • Journal Title

      内分泌・糖尿病科 26

      Pages: 141-147

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] Fusion of proinsulin-producing bone marrow-derived cells with Hepatocytes in diabetes2007

    • Author(s)
      Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L
    • Journal Title

      Proceedings of National Academy of Science of the United States of America 104

      Pages: 4030-4035

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes2007

    • Author(s)
      Fujimiya, M., Kojima, H., Ichinose, M., Arai, R., Kimura, H., Kashiwagi, A., Chan, L
    • Journal Title

      Proceedings of National Academy of science of the United States of America 104

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] 肝・骨髄幹細胞からの再生2006

    • Author(s)
      小島秀人、木村博、藤宮峯子、柏木厚典
    • Journal Title

      Diabetes Frontier 17

      Pages: 319-323

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus : Is history repeating itself2006

    • Author(s)
      Kojima, H., Fujimiya, M., Terashima, T., Kimura, H., Chan, L
    • Journal Title

      Endocrine Journal 53

      Pages: 715-722

    • NAID

      10020612249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Journal Article] Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself?2006

    • Author(s)
      Kojima H, Fujimiya M, Terashima T, Kimura H, ChanL
    • Journal Title

      Endocrine Journal 53

      Pages: 715-722

    • NAID

      10020612249

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • [Presentation] 糖尿病における骨髄幹細胞の分化異常ーTNF-alphaの発現とヒストンデアセチラーゼについてー2012

    • Author(s)
      樫美和子、小島秀人、木村博
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590378
  • [Presentation] 高血糖メモリーの解明ー骨髄におけるヒストンデアセチラーゼの発現ー2012

    • Author(s)
      小島秀人、樫美和子、木村博
    • Organizer
      第6回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590378
  • [Presentation] 脊髄後根神経節ニューロンを標的とするファージ・システムの開発2007

    • Author(s)
      小島秀人、大井二郎、寺島智也、前田健吾、藤宮峯子、新井良八、木村博、柏木厚典、安田斎
    • Organizer
      厚生労働省精神・神経疾患研究委託費、「難治性ニューロパチーの病態に基づく新規治療法の開発」班、分担研究者発表会 平成19年度班会議
    • Place of Presentation
      東京
    • Year and Date
      2007-12-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390100
  • 1.  加藤 武司 (90028382)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  TAKADA Tatsuyuki (90206756)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  TORII Ryuzo (50106647)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  佐藤 弘毅 (60029775)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  KOJIMA HIDETO (00225434)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 6.  NONAKA Masaru (40115259)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  TSUCHIYA Hideaki (10378440)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  大西 武雄 (60094554)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  古山 順一 (30068431)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  青山 喬 (60039526)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  立花 章 (20188262)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  IKEBUCHI Makoto (10121550)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HUKUHORI Nobutoshi (60199263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KUWANA Takashi (30145297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SANKAI Tadashi (80300937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FUJIMIYA Mineko (10199359)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 17.  巽 紘一 (30131022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  石井 裕 (20028509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  尾川 博昭 (50108685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  細井 美彦 (70192739)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  入谷 明 (80026385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SHIGEOKA Tadayoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KIMOTO Yasuhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  近藤 靖
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  YASUDA Hitoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  寺島 智也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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