KIMURA Hiroshi 木村博

… Alternative Names

Researcher Number	00110560
Other IDs
Affiliation (Current)	2020: 滋賀医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013: 滋賀医科大学, 医学部, 名誉教授 2011 – 2013: 滋賀医科大学, 医学部, 教授 1996 – 2007: School of Medicine, Shiga University of Medical Science, Full Professor, 医学部, 教授 1995 – 1996: 滋賀医科大学, 助教授 1995: 滋賀医科大学, 医学部, 助教授 1987 – 1989: 滋賀医科大学, 助教授 1986: 滋賀医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Radiation science / 環境影響評価(含放射線生物学) Except Principal Investigator Laboratory animal science / 環境影響評価(含放射線生物学) / Human genetics / Biological Sciences / Pathological medical chemistry
Keywords	Principal Investigator 培養細胞突然変異 / DNA塩基配列 / 放射線治療 / 抗がん剤治療 / PCR技術 / hprt遺伝子 / DNA塩基配列変化 / インビボ突然変異 / マルチプレックスPCR / RT-PCR … More Except Principal Investigator MHC / 突然変異スペクトル / シャトルベクター / HPRT遺伝子 / 遺伝子治療 / インスリン / 糖尿病 / superoxide dismutase / メダカ / サルES細胞 / GFP / ES細胞 / siRNA / TrpーP2 / 変異原特異性 / DNA修復 / PCR / HPRT^ー遺伝子 / ミユ-テーター癌遺伝子 / ミスマッチ修復 / hMLH1 / ゲノム不安定性 / 遺伝要因 / ミスマッチ修復遺伝子 / 遺伝性非ポリポ-シス大腸癌 / ゲノム不安定性機構 / 突然変異のスペクトル / ミューテーター活性 / 膵島 / 糖尿 / 再生医療 / 国際情報交換 / アメリカ合衆国 / 難治性がん / 放射線治療 / マイトマイシンC / 潜在性致死損傷の回復 / cAMP / クロマン構造 / ヒストンの修飾 / 架橋剤 / 6TG抵抗性変異 / がん原物質誘発変異 / HPRTcDNA遺伝子 / Trp-P_2誘発変異 / PCR法 / ラドン / ラドン娘核種 / ラドン吸入装置 / ラツト / 肺線維芽細胞 / 微小核 / 生物学的影響 / ラット / 突然変異 / 肺繊維芽細胞 / 気管上皮細胞 / DNA配列 / radon / radon progeny / radon exposure system / rats / lung fibroblasts / micronuclei / biological effects / 環境評価 / ゲノム構造 / リガーゼル / 毒性評価 / 補体系 / 自然免疫 / RNAi / 免疫系 / リガーゼIV / 補体 / 化学物質 / Medaka / Environmental assessment / Genome structure / DNA ligase / Toxicity test / Complement / Innate immunity / BACコンテイグ / 多型 / 進化 / 近交系 / 抗原提示 / 塩基配列決定 / BAC / 塩基配列 / ゲノム進化 / 連鎖 / BAC contig / Polymorphism / Evolution / Inhred Strain / 遺伝子改変 / 核移植 / 遺伝子導入 / 多能性 / 分化 / monkey ES cell / genetic engineering / nuclear transfer / EG細胞(embryonic germ cell) / 始原生殖細胞 / カニクイザル / EG細胞(embroyonic germ cell) / embryonic germ cell / primordial germ cell / monkey / embryonic stem cell / RNA干渉法 / ノックアウト / ノックダウン / ARL / RNA interference / knock out / 合併症 / 糖毒性 / diabetic complication / bone marrow / diabetes mellitus / insulin / TNF-α / proinsulin / gene therapy Less

Reproduction of pancreatic islet in the pancreas by gene therapy
- Principal Investigator
  
  KOJIMA HIDETO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Shiga University of Medical Science
Identification of a novel therapeutic target that produces irreversible diabeticg lucotoxicky
- Principal Investigator
  
  KOJIMA Hideto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shiga University of Medical Science
Establishment of embryonic gem cells and their differentiation into germ cells.
- Principal Investigator
  
  TORII Ryuzo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of medical science
Development of stage-specific knockout in mammals using RNA interference
- Principal Investigator
  
  TAKADA Tatsuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga university of medical science
Application of genetic engineering using ES cells in macaca.
- Principal Investigator
  
  TAKADA Tatsuyuki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga university of medical science, Research center for animal life science
Assessment using hydra of endocrine disruptors contaminated in freshwater environmentPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Shiga University of Medical Science
Evolutaionary mechanism for the adaptive immune system as revealed by the structural analysis of the medaka major histocompatibility complex
- Principal Investigator
  
  NONAKA Masaru
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of medaka models for comprehensive assessment of environmental factors
- Principal Investigator
  
  NONAKA Masaru
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tokyo
Radiation-induced apoptosis in DNA-double strand break repair deficient cells and its relation to radiation-induced fibrosisPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Shiga University of Medical Science
ミューテーター癌遺伝子をモデルとした環境変異源の発癌リスクと遺伝要因
- Principal Investigator
  
  加藤武司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ミューテーター癌遺伝子をモデルとした環境変異源の発癌リスクと遺伝要因
- Principal Investigator
  
  加藤武司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Experimental analysis of lung cancer induced by radon exposure and smoking
- Principal Investigator
  
  IKEBUCHI Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Shiga University of Medical Science
Sequence analysis of X ray-induced and anticancer drug-induced mutations in cultured mammalian cells and peripheral blood lymphocytesPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Shiga University of Medical Science
がん原物質によるDNA損傷、修復と誘発変異特異性のシャトルベクターによる解析
- Principal Investigator
  
  加藤武司
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
がん原物質によるDNA損傷、修復と誘発突然変異特異性のシャトルベクターによる解析
- Principal Investigator
  
  加藤武司
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
がん原物質によるDNA損傷, 修復と誘発変異特異性のシャトルベクターによる解析
- Principal Investigator
  
  加藤武司
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
修復機構の制御によるがん細胞の薬剤、放射線感受性の修飾
- Principal Investigator
  
  青山喬
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Shiga University of Medical Science

All 2013 2012 2008 2007 2006

All Journal Article Presentation Book

[Book] 糖尿病学の進歩20072007
- Author(s)
  小島秀人、藤宮峯子、柏木厚典、木村博
- Total Pages
  6
- Publisher
  診断と治療社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Book] 糖尿病学20072007
- Author(s)
  小島秀人、寺島智也、藤宮峯子、柏木厚典、木村博
- Total Pages
  7
- Publisher
  診断と治療社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013
- Author(s)
  H Urabe, H Kojima, L Chan, T Terashima, N Ogawa, M Katagi, K Fujino, A Kumagai, H Kawai, A Asakawa, A Inui, H Yasuda, Y Eguchi, K Oka, H Maegawa, A kashiwagi, H Kimura
- Journal Title
  
  Nat Commun
  
  Volume: 4 Pages: 1526-1526
- DOI
  10.1038/ncomms2536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590378, KAKENHI-PROJECT-23790988, KAKENHI-PROJECT-24659986
[Journal Article] 糖尿病合併症を誘導する異常骨髄細胞の同定と新規治療薬の開発2013
- Author(s)
  小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
- Journal Title
  
  滋賀貴台雑誌
  
  Volume: 26巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590378
[Journal Article] 糖尿病合併症を誘導する異常骨髄幹細胞の同定と新規治療薬の開発2013
- Author(s)
  小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
- Journal Title
  
  滋賀医大雑誌
  
  Volume: 26
- Data Source
  KAKENHI-PROJECT-23590378
[Journal Article] Isolation of specific peptides that home to dorsal root ganglion neurons in mice2008
- Author(s)
  Oi, J., Terashima, T., Kojima, H., Fujimia, M., Maeda, K., Arai, R., Chan, L., Yasuda, H., Kashiwagi, A., Kimura, H
- Journal Title
  
  Neuroscience Letters 434
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Isolation of specific peptides that home to dorsal root ganglion neuronsin mice2008
- Author(s)
  Oi J, Terashima T, Kojima H, Fujimia M, Maeda K, Arai R, Chan L, Yasuda H, Kashiwagi A, Kimura H
- Journal Title
  
  Neuroscience Letters 434
  
  Pages: 266-272
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] 膵および膵外におけるNgn3とNeuroD1の発現調節と機能2008
- Author(s)
  小島秀人、木村博
- Journal Title
  
  内分泌・糖尿病科 26
  
  Pages: 141-147
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Fusion of proinsulin-producing bone marrow-derived cells with Hepatocytes in diabetes2007
- Author(s)
  Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L
- Journal Title
  
  Proceedings of National Academy of Science of the United States of America 104
  
  Pages: 4030-4035
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes2007
- Author(s)
  Fujimiya, M., Kojima, H., Ichinose, M., Arai, R., Kimura, H., Kashiwagi, A., Chan, L
- Journal Title
  
  Proceedings of National Academy of science of the United States of America 104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] 肝・骨髄幹細胞からの再生2006
- Author(s)
  小島秀人、木村博、藤宮峯子、柏木厚典
- Journal Title
  
  Diabetes Frontier 17
  
  Pages: 319-323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself?2006
- Author(s)
  Kojima H, Fujimiya M, Terashima T, Kimura H, ChanL
- Journal Title
  
  Endocrine Journal 53
  
  Pages: 715-722
- NAID
  10020612249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Journal Article] Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus : Is history repeating itself2006
- Author(s)
  Kojima, H., Fujimiya, M., Terashima, T., Kimura, H., Chan, L
- Journal Title
  
  Endocrine Journal 53
  
  Pages: 715-722
- NAID
  10020612249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390100
[Presentation] 糖尿病における骨髄幹細胞の分化異常ーTNF-alphaの発現とヒストンデアセチラーゼについてー2012
- Author(s)
  樫美和子、小島秀人、木村博
- Organizer
  第１１回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590378
[Presentation] 高血糖メモリーの解明ー骨髄におけるヒストンデアセチラーゼの発現ー2012
- Author(s)
  小島秀人、樫美和子、木村博
- Organizer
  第６回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590378
[Presentation] 脊髄後根神経節ニューロンを標的とするファージ・システムの開発2007
- Author(s)
  小島秀人、大井二郎、寺島智也、前田健吾、藤宮峯子、新井良八、木村博、柏木厚典、安田斎
- Organizer
  厚生労働省精神・神経疾患研究委託費、「難治性ニューロパチーの病態に基づく新規治療法の開発」班、分担研究者発表会平成19年度班会議
- Place of Presentation
  東京
- Year and Date
  2007-12-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390100

1. 加藤武司 (90028382)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. TAKADA Tatsuyuki (90206756)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TORII Ryuzo (50106647)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 佐藤弘毅 (60029775)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KOJIMA HIDETO (00225434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. NONAKA Masaru (40115259)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TSUCHIYA Hideaki (10378440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 大西武雄 (60094554)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 古山順一 (30068431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 青山喬 (60039526)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 立花章 (20188262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. IKEBUCHI Makoto (10121550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HUKUHORI Nobutoshi (60199263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KUWANA Takashi (30145297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SANKAI Tadashi (80300937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUJIMIYA Mineko (10199359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
17. 巽紘一 (30131022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石井裕 (20028509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 尾川博昭 (50108685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 細井美彦 (70192739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 入谷明 (80026385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SHIGEOKA Tadayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KIMOTO Yasuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 近藤靖

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. YASUDA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 寺島智也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Hiroshi 木村 博

木村 博 キムラ ヒロシ

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Assessment using hydra of endocrine disruptors contaminated in freshwater environmentPrincipal Investigator

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Radiation-induced apoptosis in DNA-double strand break repair deficient cells and its relation to radiation-induced fibrosisPrincipal Investigator

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Sequence analysis of X ray-induced and anticancer drug-induced mutations in cultured mammalian cells and peripheral blood lymphocytesPrincipal Investigator

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KIMURA Hiroshi 木村博

木村博キムラヒロシ