ISHIDA Toshimasa 石田寿昌

Researcher Number	00111021
Other IDs
Affiliation (based on the past Project Information) *help	2005 – 2011: 大阪薬科大学, 薬学部, 教授 2001 – 2003: 大阪薬科大学, 薬学部, 教授 1994 – 1997: 大阪薬科大学, 薬学部, 教授 1994: 大阪薬科大学, 教授 1989 – 1992: Osaka University of Pharmaceutical Sciences, Professor, 薬学部, 教授 1987 – 1988: Osaka University of Pharmaceutical Sciences, 薬学部, 助教授 1986: 阪薬大, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Drug development chemistry / Physical pharmacy / Biophysics / 医薬分子機能学 Except Principal Investigator 医薬分子機能学
Keywords	Principal Investigator NMR / タウ蛋白質 / 構造解析 / 阻害剤 / 微小管結合ドメイン / tau protein / マイクロチュブル結合ドメイン / X-ray analysis / IF-4E / キャップ結合タンパク質 … More / 抑制機構 / 抗体 / 重合抑制 / Molecular Conformation / delta-Receptor Selectivity / mu / Opioid Receptor / Morphine Dimer / コンフォメーション / オピオイドレセプター / モルヒネ二量体 / モルヒネ / エンケファリン / 分子コンフオメ-ション / μ@δ-レセプタ-選択性 / 構造活性相関 / 分子コンフォメ-ション / δーレセプタ-選択性 / μ / オピオイドレセプタ- / モルヒネ2量体 / Acidic amino acid / Aromatic amino acid / Cap structure / Stacking interaction / スタッキング相互作用 / 7-メチルグアニン誘導体 / mRNA / キャップ結合蛋白質 / 酸性アミノ酸 / 芳香族アミノ酸 / キャップ構造 / 相互作用 / Alzheimer' disease inhibiting drug / self-aggregation / filament formation / microtubule-bindine domain / 自己重合 / 認知症治療薬 / 自己会合 / フィラメント形成 / 微少管結合ドメイン / molecular modeling / Spectroscopic analysis / 3D-structure / microtubule-binding domain / formation mechanism of tangle / タングル形式 / スペクトル解析 / 分子計算 / X-線結晶解析 / 立体構造解析 / タングル形成機構 / molecular design / inhibitor / expression / recombinant / procathepsin L / cathepsin L / 分子設計 / X線解析 / 発現 / 遺伝子組み換え / プロカテプシンL / カテプシンL / structure analysis / recognition / gene expression / mRNA cap structure / cap-binding protein / IFー4E / 認識機構 / 遺伝子発現 / mRNAキャップ構造 / C-H…π結合 / 食品 / C-H…Π結合 / 医薬分子設計 … More Except Principal Investigator NUCLEIC ACID / HETEROMOLECULE / INTERACTION / STRUCTURE / PEPTIDE / PNA / HETEROMDLECULE / 多重相互作用 / モデリング / 分子設計 / 作用発現 / 2本鎖切断 / クロモプロテイン / エンジイン / DNA / 超分子 Less

タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究Principal Investigator
- Principal Investigator
  
  石田寿昌
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer diseasePrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau ProteinPrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University of Pharmaceutical Sciences
Interaction between heteromolecules-Structural study and application of PNA-
- Principal Investigator
  
  DOI Mitsunobu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences (OUPS)
DNAの関与する超分子形成と機能
- Principal Investigator
  
  杉浦幸雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Molecular design of cathepsin L-specific inhibitor based on the teritiary structure.Principal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences
Expression of mRNA cap-binding protein and structure analysis of its cap recognition mechanismPrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Molecular Design of delta-Selective Morphine Dimer Based on Enkephalin ConformationPrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Physicochemical Studies on the Interactions Between Aromatic Amino Acids and mRNA Cap StucturePrincipal Investigator
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 物理化学-熱力学、その基礎と応用2010
- Author(s)
  石田寿昌
- Total Pages
  176
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-20590111
[Book] 物理化学-熱力学、その基礎と応用2009
- Author(s)
  石田寿昌
- Total Pages
  175
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-20590111
[Book] 物理系薬学I.物質の物理的性質物理系薬学I.物質の物理的性質(日本薬学会編)2005
- Author(s)
  石田寿昌
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] C-H…π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four repeat tau2012
- Author(s)
  Koushirou Sogawa, Ryouhei Okuda, Ysauko In, Toshimasa Ishida, Taizo Taniguchi, Katsuhiko Minoura, Koji Tomoo
- Journal Title
  
  J.Biochem.
  
  Volume: 151(In press)
- NAID
  10031166133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590138
[Journal Article] Interplay between I308 and Y310 residues in the their repeat of mucrotubule-binding domain is essential for tau filament formation2010
- Author(s)
  K.Naruto, K.Minoura, R.Okuda, T.Taniguchi, Y.In, T.Ishida, K.Tomoo
- Journal Title
  
  FEBS Lett. 584
  
  Pages: 4233-4236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  C.Nishiura, K.Takeuchi, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  J.Biochem.
  
  Volume: 147 Pages: 405-414
- NAID
  10027874643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Structural role of tyrosine residue in the their repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  K.Minoura, K.Takeuchi, C.Nishiura, K.Naruto, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science
  
  Volume: 2009 Pages: 227-230
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Structural role of tyrosine residue in the their repeat of microtubule binding domaion for filament formation of tau protein2010
- Author(s)
  K.Minoura, K.Takeuchi, C.Nishiura, K.Naruto, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2009
  
  Pages: 227-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Interplay between I308 and Y310 residues in the their repeat of mucrotubule-binding domain is essential for tau filament formation2010
- Author(s)
  K.Naruto, K.Minoura, R.Okuda, T.Taniguchi, Y.In, T.Ishida, K.Tomoo
- Journal Title
  
  FEBS Lett.
  
  Volume: 6584 Pages: 4233-4236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  C.Nishiura, K.Takeuchi, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  J.Biochem. 147
  
  Pages: 405-414
- NAID
  10027874643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Structural studies of specific intermolecular interactions and self-aggregation of biomolecules and their application to drug design2009
- Author(s)
  T.Ishida
- Journal Title
  
  Chem.Pharm.Bull. 57
  
  Pages: 1309-1334
- NAID
  130000124530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Inhibitory behavior of cyanidine and methylene blue for filament formation of tau microtubule-binding domain2009
- Author(s)
  E.Sugino, M.Hattori, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2008
  
  Pages: 331-334
- NAID
  10027166463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of tyrosine residue for filament formation of tau microtubule-binding domain2009
- Author(s)
  C.Nishiura, K.Takeuchi, K.Naruto, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2008
  
  Pages: 235-238
- NAID
  10027166266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Three-/four repeat-dependent aggregation profile of tau microtubule-binding domain clarified by dynamic light scattering analysis2009
- Author(s)
  E.Sugino, C.Nishiura, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 385
  
  Pages: 236-240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Role of each peptide in aggregation of tau microtubule-binding domain2008
- Author(s)
  K.Minoura, K.Okuyama, C.Nishiura, F.Mizushima, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2007
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein2008
- Author(s)
  K.Okuyama, C.Nishiura, F.Mizushima, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  FEBS Journal 275
  
  Pages: 1529-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Role of each peptide in aggregation of tau microtubule-binding domain2008
- Author(s)
  K. Minoura, K. Okuyama, C. Nishiura, F. Mizushima, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  Peptide Science 2007
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain2008
- Author(s)
  M. Hattori, E. Sugino, K. Minoura, Y. In, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Linkage-dependent contribution of repeat peptides to self-aggregation of three-or four-repeat microtubule-binding domains in tau protein2008
- Author(s)
  K. Okuyama, C. Nishiura, F. Mizushima, K. Minoura, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  FEBS Journal 275
  
  Pages: 1529-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain2008
- Author(s)
  M.Hattori, E.Sugino, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 374
  
  Pages: 158-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Effect of DNA on filament formation of tau microtubule-binding domain: Structural dependence of DNA2007
- Author(s)
  R. Hikosou, Y. Kurabayashi, M. Doumoto, K. Hoshitoku, F. Mizushima, K. Minoura, K. Tomoo, T. Ishida
- Journal Title
  
  Chem. Pharm. Bull. 55
  
  Pages: 1030-1033
- NAID
  110006317167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Marked difference between self-aggregations of first and fourth repeat peptides on microtubule-binding domain in acidic solution2007
- Author(s)
  F. Mizushima, K. Minoura, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  J. Biochem. 142
  
  Pages: 49-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effect of DNA on filament formation of tau microtubule-binding domain:Structural dependence of DNA2007
- Author(s)
  R.Hikosou, Y.Kurabayashi, M.Doumoto, K.Hoshitoku, F.Mizushima, K.Minoura, K.Tomoo, T.Ishida
- Journal Title
  
  Chem.Pharm.Bull 55
  
  Pages: 1030-1033
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effect of DNA on filament formation of tau microtubulu-binding domain:Structural dependence of DNA2007
- Author(s)
  R.Hikosou, Y.Kurabayashi, M.Doumoto, K.Hoshitoku, F.Mizushima, M.Minoura, K.Tomoo, T.Ishida
- Journal Title
  
  Chem.Pharm.Bull 55
  
  Pages: 1030-1033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution2007
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem 142
  
  Pages: 49-54
- NAID
  10020097851
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  K.Minoura, M Tokimasa, S Hiraoka, F Mizushima, K Tomoo, M Sumida, T Taniguchi, T Ishida
- Journal Title
  
  Peptide Sciences 2005
  
  Pages: 367-370
- NAID
  10017675968
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 343
  
  Pages: 712-718
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  Katsuhiko Minoura, Man Tokimasa, Shuko Hiraoka, Fumie Mizushima, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida
- Journal Title
  
  Peptide Sciences 2005
  
  Pages: 367-370
- NAID
  10017675968
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  K.Minoura, M.Tokimasa, S.Hiraoka, F.Mizushima, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 367-370
- NAID
  10017675968
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] PH-dependent filament formation of repeat peptide of microtubule-binding domain of tau protein2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 305-308
- NAID
  10017675852
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun 343
  
  Pages: 712-718
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F. Mizushima, K.Minoura, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 343
  
  Pages: 712-718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] PH-dependent filament formation of repeat peptide of microtubule-binding domain of tau protein2006
- Author(s)
  F. Mizushima, K. Minoura, K. Tomoo, S. Hiraoka, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 305-308
- NAID
  10017675852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 327
  
  Pages: 1100-1104
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T. Taniguchi, M. Sumida, S. Hiraoka, K.Tomoo, T. Kakehi, K.Minoura, S. Sugiyama, K.Inaka, T. Ishida, N. Saito, C. Tanaka
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 1399-1404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformational change of third repeat fragment of microtubule-binding domain responsible for filament formation of tauprotein2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2004
  
  Pages: 545-548
- NAID
  10014460563
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domair2005
- Author(s)
  K. Minoura, F. Mizushima, M. Tokimasa, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 327
  
  Pages: 1100-1104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strucutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K.Tomoo, T.-M.Yao, K.Minoura, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem 138
  
  Pages: 413-423
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M.Tokimasa, K.Minoura, S.Hiraoka, K.Tomoo, Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformarional change of third repeat fragment of microtubule-binding domain responsible for filament formation of tau protein2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Protein Science 2004
  
  Pages: 545-548
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M. Tokimasa, K. Minoura, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strucutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K. Tomoo, T.-M. Yao, K. Minoura, S. Hiraoka, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  J. Biochem. 138
  
  Pages: 413-423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformational change of third repeat fragment of microtubule-binding domain responsible for fliament formation of tau protein.2005
- Author(s)
  K. Minoura, F. Mizushirna, M. Tokimasa, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Peptide Science 2004
  
  Pages: 545-548
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun 327
  
  Pages: 1100-1104
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strcuutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K.Tomoo, T.M.Yao, K.Minoura, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem. 138
  
  Pages: 413-423
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M.Tokimasa, K.Minoura, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis:RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T.Taniguchi, M.Sumida, S.Hiraoka, K.Tomoo, T.Kakehi, K.Minoura, S.Sugiyama, K.Inaka, T.Ishida, N.Saito, C.Tanaka
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 1399-1404
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis : RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T.Taniguchi, M.Sumida, S.Hiraoka, K.Tomoo, T.Kakehi, K.Minoura, S.Sugiyama, K.Inaka, T.Ishida, N.Saito, C.Tanaka
- Journal Title
  
  FEBS Lett 579
  
  Pages: 1399-1404
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質の自己重合におけるIle308とTyr310が形成するCH-π相互作用の重要性2012
- Author(s)
  曾川甲子郎, 奥田良平, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会132年会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその複合体結晶化による構造機能解析2012
- Author(s)
  須佐匡樹, 土屋孝弘, 箕浦克彦, 尹康子, 友尾幸司, 谷口泰造, 辻坊裕, 石田寿昌
- Organizer
  日本薬学会132年会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己重合におけるIle308とTyr310が形成するCH-π相互作用の重要性2011
- Author(s)
  曾川甲子郎, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその構造機能解析2011
- Author(s)
  須佐匡樹, 土屋孝弘, 箕浦克彦, 尹康子, 友尾幸司, 辻坊裕, 石田寿昌, 他
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] CH-π interaction between I308 and Y310 residues is required for self assembly of full length tau2011
- Author(s)
  曾川甲子郎, 奥田良平, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌, 他
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその構造機能解析2010
- Author(s)
  木挽友博、土屋孝弘、箕浦克彦、尹康子、友尾幸司、谷口泰造、辻坊裕、石田寿昌
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Full length tauの自己重合におけるCH-π相互作用の重要性について2010
- Author(s)
  奥田良平、鳴戸佳子、箕浦克彦、尹康子、友尾幸司、谷口泰造、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Full length tau の自己重合におけるCH-π相互作用の重要性について2010
- Author(s)
  奥田良平、鳴戸佳子、箕浦克彦、尹康子、友尾幸司、谷口泰造、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)におけるCH-π相互作用がもたらすフィラメント形成能への影響について2010
- Author(s)
  曽川甲子朗、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)の自己重合におけるTyrosine残基と周囲のアミノ酸残基の重要性について2010
- Author(s)
  鳴戸佳子、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質微小管結合ドメインのフィラメント形成に対するCyanidin(Cy)とMethylene Blue(MB)の阻害作用の差異について2009
- Author(s)
  杉野恵津子、服部正幹、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメインに存在する Tyrosine の構造学的役割2009
- Author(s)
  竹内健悟, 西浦千里, 箕浦克彦, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク微小管結合ドメイン(MBD)の自己重合におけるTyrosine残基の重要性について2009
- Author(s)
  鳴戸佳子、箕浦克彦、尹康子、友尾幸司、辻坊裕、石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメインに存在するTyrosineの構造学的役割2009
- Author(s)
  西浦千里、竹内健悟、鳴戸佳子、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)の自己重合における Tyrosine 残基の役割2009
- Author(s)
  西浦千里, 竹内健悟, 鳴戸佳子, 箕浦克彦, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質微小管結合ドメインのフィラメント形成に対する Cyanidin(Cy)と Methylene Blue(MB)の阻害作用の差異について2009
- Author(s)
  杉野恵津子, 服部正幹, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tau蛋白質の自己凝集抑制能を有する特異的認識抗体の作成とその構造解析2009
- Author(s)
  木挽友博、土屋孝弘、箕浦克彦、尹康子、友尾幸司、辻坊裕、石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク微小管結合ドメイン(MBD)の自己重合における Tyrosine 残基の重要性について2009
- Author(s)
  鳴戸佳子, 箕浦克彦, 尹康子, 友尾幸司, 辻坊裕, 石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)の自己重合におけるTyrosine残基の重要性について2008
- Author(s)
  西浦千里、竹内健悟、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質の凝集抑制物質の検索とその抑制機構解明2008
- Author(s)
  服部正幹、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質の微小管結合ドメインに存在するTyrosinwが構造に与える影響2008
- Author(s)
  竹内健悟、西浦千里、箕浦克彦、友尾幸司、尹康子、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質の凝集抑制物質の検索とその抑制機構解明2008
- Author(s)
  服部正幹、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Cyanidine(Cy)とMethylene Blue(MB)におけるTauタンパク質微小管結合部位のフィラメント形成抑制作用の差異2008
- Author(s)
  杉野恵津子、服部正幹、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質中の微小管結合ドメインの自己凝縮機構の解析2007
- Author(s)
  奥山佳代子、寳田久美子、竹内健悟、西浦千里、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質の凝集抑制物質の検索とその制御機構2007
- Author(s)
  服部正幹、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2007-10-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Role of Each Repeat Peptide in Aggregation of Tau Micritubule-binding Domain2007
- Author(s)
  箕浦克彦、奥山佳代子、西浦千里、水嶋史絵、友尾幸司、石田寿昌
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山
- Year and Date
  2007-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質微小管結合ドメインと各リピートペプチドにおけるフィラメント形成能のpH依存性について2006
- Author(s)
  水島史絵、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Year and Date
  2006-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質中の微小管結合ドメインの自己凝集機構の解析2006
- Author(s)
  奥山佳代子、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  第56回日本薬学会近畿支部大会
- Place of Presentation
  京都
- Year and Date
  2006-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質微少管結合部位の各リピートドメインにおけるフィラメント形成能のpH依存性について2005
- Author(s)
  水島史絵、箕浦克彦、友尾幸司、平岡周子、石田寿昌
- Organizer
  第42回ペプチド討論会
- Place of Presentation
  大阪
- Year and Date
  2005-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質微少管結合部位の各リピートドメインにおけるフィラメント形成能の差異について2005
- Author(s)
  水島史絵、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  第55回本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川
- Year and Date
  2005-10-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質MBDのwild type及びFTDP-17変異体におけるコンフォメーションとフィラメント形成との相関について2005
- Author(s)
  平岡周子、小林靖久、田辺博章、時政真理、箕浦克彦、友尾幸司、石田寿昌
- Organizer
  日本薬学会第125年会
- Place of Presentation
  東京
- Year and Date
  2005-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tau蛋白質微少管結合ドメインの自己凝集におけるリピートフラグメントN末端二次構造の重要性2005
- Author(s)
  箕浦克彦、時政真理、平岡周子、水島史絵、友尾幸司、石田寿昌
- Organizer
  第42回ペプチド討論会
- Place of Presentation
  大阪
- Year and Date
  2005-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] tauタンパク質に存在する微少管結合ドメイン内フラグメントの溶液構造解析2005
- Author(s)
  時政真理、箕浦克彦、平岡周子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第125年会
- Place of Presentation
  東京
- Year and Date
  2005-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590045

1. IN Yasuko (50257896)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. TOMOO Koji (70257898)

# of Collaborated Projects: 7 results

# of Collaborated Products: 77 results
3. MINOURA Katsuhiko (10278591)

# of Collaborated Projects: 4 results

# of Collaborated Products: 77 results
4. DOI Mitsunobu (10183500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ASANO Akiko (40291801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANIGUCHI Taizo (70346253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
7. 杉浦幸雄 (40025698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋孝志 (80110724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平間正博 (30165203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 樽井麻里子 (60257897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAFUKU Yayoi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. いん康子

# of Collaborated Projects: 0 results

# of Collaborated Products: 61 results

ISHIDA Toshimasa 石田 寿昌

Research Projects

Research Products

Co-Researchers

タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究Principal Investigator

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Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer diseasePrincipal Investigator

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Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's diseasePrincipal Investigator

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Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau ProteinPrincipal Investigator

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Interaction between heteromolecules-Structural study and application of PNA-

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DNAの関与する超分子形成と機能

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Molecular design of cathepsin L-specific inhibitor based on the teritiary structure.Principal Investigator

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Expression of mRNA cap-binding protein and structure analysis of its cap recognition mechanismPrincipal Investigator

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Molecular Design of delta-Selective Morphine Dimer Based on Enkephalin ConformationPrincipal Investigator

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Physicochemical Studies on the Interactions Between Aromatic Amino Acids and mRNA Cap StucturePrincipal Investigator

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[Book] 物理化学-熱力学、その基礎と応用2010

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[Book] 物理化学-熱力学、その基礎と応用2009

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[Book] 物理系薬学I.物質の物理的性質物理系薬学I.物質の物理的性質(日本薬学会編)2005

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[Journal Article] C-H…π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four repeat tau2012

Author(s)

Journal Title

ISHIDA Toshimasa 石田寿昌