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HAYASHI Yayoi  林 弥生

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… Alternative Names

林 弥生  ハヤシ ヤヨイ

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Researcher Number 00117847
Other IDs
Affiliation (based on the past Project Information) *help 2006 – 2010: 金城学院大学, 薬学部, 教授
2004 – 2005: 名古屋市立大学, 大学院・薬学研究科, 講師
2002: Graduate School of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究科, 講師
1999 – 2001: 名古屋市立大学, 薬学部, 講師
1992: 名古屋市立大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Medical pharmacy / Physical pharmacy
Except Principal Investigator
Medical pharmacy / 医薬分子機能学 / Physical pharmacy / 疼痛学
Keywords
Principal Investigator
Lactobacillus casei / ラット / 消化管吸収 / small intestine / nifedipine / rat / first-pass metabolism / absorption / probiotics / CYP3A … More / 反転腸管 / 1回灌流法 / 小腸 / ニフェジピン / 初回通過代謝 / プロバイオティクス / brain capillary endothelial cell / peritoneal macrophage / Kupffer cell / liver parenchymal cell / scavenger receptor / targeting / fractionated heparin / macromolecular drug / マクロファージ / クローニング / ターゲッラィング / 脳毛細血管内皮細胞 / 腹腔マクロファージ / クッパー細胞 / 肝実質細胞 / スカベンジャー受容体 / ターゲッティング / 分画ヘパリン / 高分子量薬物 / フラボノイド類 / 発現制御 / 転写因子 / hPCFT / フラボノイド / エタノール / 転写抑制因子 / 転写活性化因子 / PCFT / トランスポーター / メトトレキセート / 葉酸 … More
Except Principal Investigator
carrier-mediated transport / 担体輸送 / HCT-15 cell / transporter / glycerol / HCT-15細胞 / トランスポーター / グリセロール / 吸収 / CYP3A / competitive inhibition / differentiation / Nat-dependent transport / 酪酸 / Na^+依存性 / ジグリセロール / モノアセチン / 競合阻害 / 分化誘導 / ナトリウム依存性 / polyol / intestine / rat / Na^+-dependent transport / クロラムフェニコール / アルコール / 多価アルコール / NCT-15細胞 / 腸管 / ラット / Na^+依存性輸送 / P-glycoprotein / cyclosporine / riboflavin / first-pass metabolism / small intestine / colon / 徐放剤 / 細胞生物学 / 薬物動態学 / ニフェジピン / 除放剤 / タウロコール酸 / グルコース / P糖タンパク質 / シクロスポリン / リボフラビン / 初回通過代謝 / 小腸 / 結腸 / albumin / a-globulin / plasma protein / anion transport system / transport inhibitor / dose-dependent uptake / fractionated heparin / rat parenchymal hepatocyte / 血清アルブミン / alpha-グロブリン / 血清アルグミン / α-グロブリン / 血漿蛋白 / アニオン輸送系 / 輸送阻害剤 / 濃度依存的肝取込み / 分画ヘパリン / ラット培養肝実質細胞 / インターナリゼーション / 受容体内在化 / 痛覚過敏 / 脱感作 / ブラジキニンB2受容体 / プロスタグランジンEP3受容体 Less
  • Research Projects

    (8 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (7 People)
  •  Regulation of intestinal expression of proton-coupled folate transporter and its relevance to folate malabsorption in alcohol consumption.Principal Investigator

    • Principal Investigator
      HAYASHI Yayoi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kinjo Gakuin University
  •  The attenuation mechanism of bradykinin B2 receptor desensitization through prostaglandin EP3 receptor

    • Principal Investigator
      KOZAKI Yasuko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      疼痛学
    • Research Institution
      Kinjo Gakuin University
  •  Molecular and Functional Characteristics of Glycerol Transporter in HCT-15 Cell Model

    • Principal Investigator
      YUASA Hiroaki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagoya City University
  •  Effect of Probiotics on the absorption of drugs from the Small IntestinePrincipal Investigator

    • Principal Investigator
      HAYASHI Yayoi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kinjo Gakuin University
  •  Novel Transporter Responsible for Intestinal Glycerol Absorption : Characterization of Its Function and Physiological Role

    • Principal Investigator
      YUASA Hiroaki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagoya City University
  •  Pharmacokinetic and Cellular Biological Study on Colonic Absorption : Strategies for Optimized Controlled Release Oral Drug Delivery

    • Principal Investigator
      YUASA Hiroaki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Nagoya City University
  •  Quantitative and Molecular Mechanism-Based Analysis of Factors Interfering with Macromolecular Drug TargetingPrincipal Investigator

    • Principal Investigator
      HAYASHI Yayoi, 渡辺 淳
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University
  •  Pharmacokinetic Study on Mucopolysaccharide : Effect of Plasma Protein on the Hepatic Uptake of fractionated Heparin

    • Principal Investigator
      WATANABE Jun
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Nagoya City University

All 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Molecular and functional characteristics of proton-coupled folate transporter.2009

    • Author(s)
      Hiroaki Yuasa, Katsuhisa Inoue, Yayoi Hayashi
    • Journal Title

      J.Pharm.Sci. 98

      Pages: 1608-1616

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Journal Article] プロトン/葉酸共輸送担体の発現制御に関わる転写因子の検索2009

    • Author(s)
      湯浅博昭,高橋絢子,太田欣哉,井上勝央,畠山舞,林弥生
    • Journal Title

      薬剤学 69

    • Data Source
      KAKENHI-PROJECT-20590163
  • [Journal Article] Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.2008

    • Author(s)
      Katsuhisa Inoue, Yasuhiro Nakai, Sayaka Ueda, Shunsuke Kamigaso, Kinya Ohta, Mai Hatakeyama, Yayoi Hayashi, Masaki Otagiri, Hiroaki Yuasa
    • Journal Title

      Am.J.Physiol. 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Journal Article] Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.2007

    • Author(s)
      Ryuji Kato, Hiroaki Yuasa, Katsuhisa Inoue, Takahiro Iwao, Kazuhiko Tanaka, Kazuya Ooi, Yayoi Hayashi
    • Journal Title

      Drug Metab. Pharmacokinet. 22(3)

      Pages: 9-102

    • NAID

      10019923271

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Journal Article] ラット小腸ループにおける薬物腸管膜透過に及ぼすカゼイ菌の影響2006

    • Author(s)
      林 弥生, ら
    • Journal Title

      薬剤学 66

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Journal Article] Effect of Lactobacillus casei on intestinal absorption of drugs after administration into the small intestinal loops in Rats2006

    • Author(s)
      Yayoi Hayashi, Emiru Takeda, Shunsuke Kamigaso, Katsuhisa Inoue, Hiroaki Yuasa, Ryuji Kato, Kazuya Ooi
    • Journal Title

      Jpn. J. Pharm. Sci. Technol. 66

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Journal Article] Effect of Lactobacillus casei on gastrointestinal motility : intestinal disposition of[^3H]PEG-4000(non-absorbable marker).2005

    • Author(s)
      Emiru Takeda, Yayoi Hayashi, Mai Hatakeyama, Katsuhisa Inoue, Hiroaki Yuasa, Kazuya Ooi, Ryuji Kato
    • Journal Title

      Jpn. J. Pharm. Sci. Technol. 65

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] PCFTを介する葉酸類の輸送に対するフラボノイド類の影響2011

    • Author(s)
      西嶋千尋,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] PCFTの転写調節におけるKLF4とHNF-4αの関与2010

    • Author(s)
      畠山舞,太田欣哉,井上勝央,林弥生,湯浅博昭
    • Organizer
      第25回日本薬物動態学会年会
    • Place of Presentation
      さいたま
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] Effects of flavonoids on proton-coupled folate transporter.2010

    • Author(s)
      Yuasa, H., Nishijima, C., Hatakeyama, M., Hayashi, Y., Ohta, K., Inoue, K.
    • Organizer
      Pharmaceutical Sciences World Congress 2010 (4th)
    • Place of Presentation
      New Orleans, Louisiana, U.S.A
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] Caco-2細胞における葉酸類の取り込みに対するエタノール及びフラボノイド類の影響2010

    • Author(s)
      西嶋千尋,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] Effects of flavonoids on proton-coupled folate transporter.2010

    • Author(s)
      Hiroaki Yuasa, Chihiro Nishijima, Mai Hatakeyama, Yayoi Hayashi, Kinya Ohta, Katsuhisa Inoue
    • Organizer
      Pharmaceutical Sciences World Congress 2010 (4th)
    • Place of Presentation
      New Orleans, Louisiana, U.S.A.
    • Year and Date
      2010-11-16
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] PCFTの転写調節におけるKLF4とHNF-4αの関与2010

    • Author(s)
      畠山舞, 太田欣哉, 井上勝央, 林弥生, 湯浅博昭
    • Organizer
      第25回日本薬物動態学会年会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] プロトン/葉酸共輸送担体の発現制御に関わる転写因子の検索2009

    • Author(s)
      湯浅博昭,高橋絢子,太田欣哉,井上勝央,畠山舞,林弥生
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] 小腸に存在する転写因子による葉酸/H^+共輸送担体(PCFT)の発現制御2008

    • Author(s)
      高橋絢子,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] Functional characteristics of human proton-coupled folate transporter/heme carrier protein 1 (hPCFT/HCP1) heterologously expressed in mammalian cells.2008

    • Author(s)
      Misato Sugiura, Katsuhisa Inoue, Yasuhiro Nakai, Naoki Abe, Kinya Ohta, Mai Hatakeyama, Yayoi Hayashi, Hiroaki Yuasa
    • Organizer
      Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences (The 4th US-Japan Joint Conference)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-02-22
    • Data Source
      KAKENHI-PROJECT-20590163
  • [Presentation] Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.2006

    • Author(s)
      Kato R., Hayashi Y., Takeda E., Iwao T., Tanaka K., Ooi K., Yuasa H.
    • Organizer
      The 126 Annual Meeting of Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei on the gastrointestinal absorption of nifedipine after oral administration in rats.2006

    • Author(s)
      Hayashi Y., Kato R., Inoue K., Yuasa H.
    • Organizer
      The 16 Annual Meeting of Japanese Society of Pharmaceutical Health Care and Sciences
    • Place of Presentation
      Kanazawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] ラット小腸でのnifedipine吸収に及ぼすLactobacillus caseiの影響2006

    • Author(s)
      加藤 隆児, 林 弥生, ら
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響2006

    • Author(s)
      林 弥生, ら
    • Organizer
      第16回日本医療薬学会年会
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei on gastrointestinal motility in rats2005

    • Author(s)
      Hayashi, Y., et. al.
    • Organizer
      US-Japan Conference on Drug Development and Rational Drug Design
    • Place of Presentation
      Los Angeles,California,U.S.A.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei strain Shirota on gastrointestinal motility in rats.2005

    • Author(s)
      Takeda E., Hayashi, Y., Hatakeyama, M., Ooi, K., Kato, R., Inoue, K., Yuasa, H.
    • Organizer
      13th NA ISSX/20th JSSX Meeting
    • Place of Presentation
      Maui, Hawaii, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei on gastrointestinal motility in rats.2005

    • Author(s)
      Hayashi, Y., Takeda, E., Inoue, K., Yuasa, H., Ooi, K., Kato, R.
    • Organizer
      US-Japan Conference on Drug Development and Rational Drug Design
    • Place of Presentation
      Los Angeles, California, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] 薬物消化管吸収に及ぼすカゼイ菌(プロバイオティクス)の影響:ラット小腸ループ法による検討2005

    • Author(s)
      武田 恵視、林 弥生, ら
    • Organizer
      平成17年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei on the uptake of some drugs into everted sacs in rats.2005

    • Author(s)
      Mizuno, N., Hayashi, Y., Ooi, K., Kato, R., Inoue, K., Yuasa H., Kato R., Ooi K.
    • Organizer
      Meeting of Tokai Branch, Pharmaceutical Society of Japan
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] Effect of Lactobacillus casei on drug absorption : investigation by using the small intestinal loop tequnique in Rats.2005

    • Author(s)
      Takeda E., Hayashi Y., Kamigaso S., Hatakeyama M., Inoue K., Yuasa H., Kato R., Ooi K.
    • Organizer
      Meeting of Tokai Branch, Pharmaceutical Society of Japan
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • [Presentation] ラット反転腸管における各種薬物の腸管膜透過に対するL.casei投与の影響2005

    • Author(s)
      水野 奈津子、林 弥生, ら
    • Organizer
      平成17年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590151
  • 1.  YUASA Hiroaki (20191471)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 9 results
  • 2.  INOUE Katsuhisa (50315892)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 20 results
  • 3.  WATANABE Jun (80080175)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  HATAKEYAMA Mai (20454340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 5.  KOZAKI Yasuko (20126882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIZUMURA Kazue (00109349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HABA Masami (70254307)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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