HAYASHI Yayoi 林弥生

… Alternative Names

Researcher Number	00117847
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2010: 金城学院大学, 薬学部, 教授 2004 – 2005: 名古屋市立大学, 大学院・薬学研究科, 講師 2002: Graduate School of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究科, 講師 1999 – 2001: 名古屋市立大学, 薬学部, 講師 1992: 名古屋市立大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Physical pharmacy Except Principal Investigator Medical pharmacy / 疼痛学 / Physical pharmacy / 医薬分子機能学
Keywords	Principal Investigator 消化管吸収 / ラット / Lactobacillus casei / 葉酸 / メトトレキセート / トランスポーター / PCFT / 転写活性化因子 / 転写抑制因子 / エタノール … More Except Principal Investigator 担体輸送 / carrier-mediated transport / CYP3A / 吸収 / グリセロール / トランスポーター / HCT-15細胞 / glycerol / transporter / HCT-15 cell / プロスタグランジンEP3受容体 / ブラジキニンB2受容体 / 脱感作 / 痛覚過敏 / 受容体内在化 / インターナリゼーション / ラット培養肝実質細胞 / 分画ヘパリン / 濃度依存的肝取込み / 輸送阻害剤 / アニオン輸送系 / 血漿蛋白 / α-グロブリン / 血清アルグミン / alpha-グロブリン / 血清アルブミン / rat parenchymal hepatocyte / fractionated heparin / dose-dependent uptake / transport inhibitor / anion transport system / plasma protein / a-globulin / albumin / 結腸 / 小腸 / 初回通過代謝 / リボフラビン / シクロスポリン / P糖タンパク質 / グルコース / タウロコール酸 / 除放剤 / ニフェジピン / 薬物動態学 / 細胞生物学 / 徐放剤 / colon / small intestine / first-pass metabolism / riboflavin / cyclosporine / P-glycoprotein / Na^+依存性輸送 / ラット / 腸管 / NCT-15細胞 / 多価アルコール / アルコール / クロラムフェニコール / Na^+-dependent transport / rat / intestine / polyol / ナトリウム依存性 / 分化誘導 / 競合阻害 / モノアセチン / ジグリセロール / Na^+依存性 / 酪酸 / Nat-dependent transport / differentiation / competitive inhibition Less

Regulation of intestinal expression of proton-coupled folate transporter and its relevance to folate malabsorption in alcohol consumption.Principal Investigator
- Principal Investigator
  
  HAYASHI Yayoi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinjo Gakuin University
The attenuation mechanism of bradykinin B2 receptor desensitization through prostaglandin EP3 receptor
- Principal Investigator
  
  KOZAKI Yasuko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Kinjo Gakuin University
Molecular and Functional Characteristics of Glycerol Transporter in HCT-15 Cell Model
- Principal Investigator
  
  YUASA Hiroaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Effect of Probiotics on the absorption of drugs from the Small IntestinePrincipal Investigator
- Principal Investigator
  
  HAYASHI Yayoi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinjo Gakuin University
Novel Transporter Responsible for Intestinal Glycerol Absorption : Characterization of Its Function and Physiological Role
- Principal Investigator
  
  YUASA Hiroaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Pharmacokinetic and Cellular Biological Study on Colonic Absorption : Strategies for Optimized Controlled Release Oral Drug Delivery
- Principal Investigator
  
  YUASA Hiroaki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nagoya City University
Quantitative and Molecular Mechanism-Based Analysis of Factors Interfering with Macromolecular Drug TargetingPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yayoi, 渡辺淳
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagoya City University
Pharmacokinetic Study on Mucopolysaccharide : Effect of Plasma Protein on the Hepatic Uptake of fractionated Heparin
- Principal Investigator
  
  WATANABE Jun
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagoya City University

All 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Molecular and functional characteristics of proton-coupled folate transporter.2009
- Author(s)
  Hiroaki Yuasa, Katsuhisa Inoue, Yayoi Hayashi
- Journal Title
  
  J.Pharm.Sci. 98
  
  Pages: 1608-1616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590163
[Journal Article] プロトン/葉酸共輸送担体の発現制御に関わる転写因子の検索2009
- Author(s)
  湯浅博昭,高橋絢子,太田欣哉,井上勝央,畠山舞,林弥生
- Journal Title
  
  薬剤学 69
- Data Source
  KAKENHI-PROJECT-20590163
[Journal Article] Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.2008
- Author(s)
  Katsuhisa Inoue, Yasuhiro Nakai, Sayaka Ueda, Shunsuke Kamigaso, Kinya Ohta, Mai Hatakeyama, Yayoi Hayashi, Masaki Otagiri, Hiroaki Yuasa
- Journal Title
  
  Am.J.Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590163
[Journal Article] Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.2007
- Author(s)
  Ryuji Kato, Hiroaki Yuasa, Katsuhisa Inoue, Takahiro Iwao, Kazuhiko Tanaka, Kazuya Ooi, Yayoi Hayashi
- Journal Title
  
  Drug Metab. Pharmacokinet. 22(3)
  
  Pages: 9-102
- NAID
  10019923271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Journal Article] ラット小腸ループにおける薬物腸管膜透過に及ぼすカゼイ菌の影響2006
- Author(s)
  林弥生, ら
- Journal Title
  
  薬剤学 66
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590151
[Journal Article] Effect of Lactobacillus casei on intestinal absorption of drugs after administration into the small intestinal loops in Rats2006
- Author(s)
  Yayoi Hayashi, Emiru Takeda, Shunsuke Kamigaso, Katsuhisa Inoue, Hiroaki Yuasa, Ryuji Kato, Kazuya Ooi
- Journal Title
  
  Jpn. J. Pharm. Sci. Technol. 66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Journal Article] Effect of Lactobacillus casei on gastrointestinal motility : intestinal disposition of[^3H]PEG-4000(non-absorbable marker).2005
- Author(s)
  Emiru Takeda, Yayoi Hayashi, Mai Hatakeyama, Katsuhisa Inoue, Hiroaki Yuasa, Kazuya Ooi, Ryuji Kato
- Journal Title
  
  Jpn. J. Pharm. Sci. Technol. 65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] PCFTを介する葉酸類の輸送に対するフラボノイド類の影響2011
- Author(s)
  西嶋千尋,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] PCFTの転写調節におけるKLF4とHNF-4αの関与2010
- Author(s)
  畠山舞,太田欣哉,井上勝央,林弥生,湯浅博昭
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  さいたま
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] Effects of flavonoids on proton-coupled folate transporter.2010
- Author(s)
  Yuasa, H., Nishijima, C., Hatakeyama, M., Hayashi, Y., Ohta, K., Inoue, K.
- Organizer
  Pharmaceutical Sciences World Congress 2010 (4th)
- Place of Presentation
  New Orleans, Louisiana, U.S.A
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] Caco-2細胞における葉酸類の取り込みに対するエタノール及びフラボノイド類の影響2010
- Author(s)
  西嶋千尋,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] Effects of flavonoids on proton-coupled folate transporter.2010
- Author(s)
  Hiroaki Yuasa, Chihiro Nishijima, Mai Hatakeyama, Yayoi Hayashi, Kinya Ohta, Katsuhisa Inoue
- Organizer
  Pharmaceutical Sciences World Congress 2010 (4th)
- Place of Presentation
  New Orleans, Louisiana, U.S.A.
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] PCFTの転写調節におけるKLF4とHNF-4αの関与2010
- Author(s)
  畠山舞, 太田欣哉, 井上勝央, 林弥生, 湯浅博昭
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  埼玉
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] プロトン/葉酸共輸送担体の発現制御に関わる転写因子の検索2009
- Author(s)
  湯浅博昭,高橋絢子,太田欣哉,井上勝央,畠山舞,林弥生
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] 小腸に存在する転写因子による葉酸/H^+共輸送担体(PCFT)の発現制御2008
- Author(s)
  高橋絢子,畠山舞,林弥生,太田欣哉,井上勝央,湯浅博昭
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] Functional characteristics of human proton-coupled folate transporter/heme carrier protein 1 (hPCFT/HCP1) heterologously expressed in mammalian cells.2008
- Author(s)
  Misato Sugiura, Katsuhisa Inoue, Yasuhiro Nakai, Naoki Abe, Kinya Ohta, Mai Hatakeyama, Yayoi Hayashi, Hiroaki Yuasa
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences (The 4th US-Japan Joint Conference)
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2008-02-22
- Data Source
  KAKENHI-PROJECT-20590163
[Presentation] Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.2006
- Author(s)
  Kato R., Hayashi Y., Takeda E., Iwao T., Tanaka K., Ooi K., Yuasa H.
- Organizer
  The 126 Annual Meeting of Pharmaceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei on the gastrointestinal absorption of nifedipine after oral administration in rats.2006
- Author(s)
  Hayashi Y., Kato R., Inoue K., Yuasa H.
- Organizer
  The 16 Annual Meeting of Japanese Society of Pharmaceutical Health Care and Sciences
- Place of Presentation
  Kanazawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] ラット小腸でのnifedipine吸収に及ぼすLactobacillus caseiの影響2006
- Author(s)
  加藤隆児, 林弥生, ら
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Year and Date
  2006-03-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響2006
- Author(s)
  林弥生, ら
- Organizer
  第16回日本医療薬学会年会
- Place of Presentation
  金沢
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei on gastrointestinal motility in rats2005
- Author(s)
  Hayashi, Y., et. al.
- Organizer
  US-Japan Conference on Drug Development and Rational Drug Design
- Place of Presentation
  Los Angeles,California,U.S.A.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei strain Shirota on gastrointestinal motility in rats.2005
- Author(s)
  Takeda E., Hayashi, Y., Hatakeyama, M., Ooi, K., Kato, R., Inoue, K., Yuasa, H.
- Organizer
  13th NA ISSX/20th JSSX Meeting
- Place of Presentation
  Maui, Hawaii, U.S.A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei on gastrointestinal motility in rats.2005
- Author(s)
  Hayashi, Y., Takeda, E., Inoue, K., Yuasa, H., Ooi, K., Kato, R.
- Organizer
  US-Japan Conference on Drug Development and Rational Drug Design
- Place of Presentation
  Los Angeles, California, U.S.A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] 薬物消化管吸収に及ぼすカゼイ菌(プロバイオティクス)の影響:ラット小腸ループ法による検討2005
- Author(s)
  武田恵視、林弥生, ら
- Organizer
  平成17年度日本薬学会東海支部例会
- Place of Presentation
  名古屋
- Year and Date
  2005-12-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei on the uptake of some drugs into everted sacs in rats.2005
- Author(s)
  Mizuno, N., Hayashi, Y., Ooi, K., Kato, R., Inoue, K., Yuasa H., Kato R., Ooi K.
- Organizer
  Meeting of Tokai Branch, Pharmaceutical Society of Japan
- Place of Presentation
  Nagoya
- Year and Date
  2005-12-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] Effect of Lactobacillus casei on drug absorption : investigation by using the small intestinal loop tequnique in Rats.2005
- Author(s)
  Takeda E., Hayashi Y., Kamigaso S., Hatakeyama M., Inoue K., Yuasa H., Kato R., Ooi K.
- Organizer
  Meeting of Tokai Branch, Pharmaceutical Society of Japan
- Place of Presentation
  Nagoya
- Year and Date
  2005-12-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590151
[Presentation] ラット反転腸管における各種薬物の腸管膜透過に対するL.casei投与の影響2005
- Author(s)
  水野奈津子、林弥生, ら
- Organizer
  平成17年度日本薬学会東海支部例会
- Place of Presentation
  名古屋
- Year and Date
  2005-12-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590151

1. YUASA Hiroaki (20191471)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
2. INOUE Katsuhisa (50315892)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
3. WATANABE Jun (80080175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HATAKEYAMA Mai (20454340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. KOZAKI Yasuko (20126882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIZUMURA Kazue (00109349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HABA Masami (70254307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYASHI Yayoi 林 弥生

林 弥生 ハヤシ ヤヨイ

Research Projects

Research Products

Co-Researchers

Regulation of intestinal expression of proton-coupled folate transporter and its relevance to folate malabsorption in alcohol consumption.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The attenuation mechanism of bradykinin B2 receptor desensitization through prostaglandin EP3 receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and Functional Characteristics of Glycerol Transporter in HCT-15 Cell Model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of Probiotics on the absorption of drugs from the Small IntestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel Transporter Responsible for Intestinal Glycerol Absorption : Characterization of Its Function and Physiological Role

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacokinetic and Cellular Biological Study on Colonic Absorption : Strategies for Optimized Controlled Release Oral Drug Delivery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative and Molecular Mechanism-Based Analysis of Factors Interfering with Macromolecular Drug TargetingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacokinetic Study on Mucopolysaccharide : Effect of Plasma Protein on the Hepatic Uptake of fractionated Heparin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular and functional characteristics of proton-coupled folate transporter.2009

Author(s)

Journal Title

Data Source

[Journal Article] プロトン/葉酸共輸送担体の発現制御に関わる転写因子の検索2009

Author(s)

Journal Title

Data Source

[Journal Article] Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.2008

Author(s)

Journal Title

Data Source

[Journal Article] Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] ラット小腸ループにおける薬物腸管膜透過に及ぼすカゼイ菌の影響2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effect of Lactobacillus casei on intestinal absorption of drugs after administration into the small intestinal loops in Rats2006

Author(s)

Journal Title

Description

HAYASHI Yayoi 林弥生

林弥生ハヤシヤヨイ