Ohata Hisayuki 大幡久之

… Alternative Names

OHATA Hisayuki 大幡久之

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Researcher Number	00119166
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 教養部, 客員教授
Affiliation (based on the past Project Information) *help	2009 – 2011: Showa University, 薬学部, 准教授 2001 – 2005: 昭和大学, 薬学部, 助教授 1998 – 1999: 昭和大学, 薬学部, 助教授 1989 – 1990: 昭和大学, 薬学部・薬理学教室, 助手
Review Section/Research Field	Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / Biological pharmacy / General physiology Except Principal Investigator Psychiatric science / Functional basic dentistry / General pharmacology / Biological pharmacy
Keywords	Principal Investigator laser scanning confocal microscopy / mechanosensitive channel / mechanoreception / 細胞内Ca^<2+>イオン濃度 / リゾホスファチジン酸 / 機械受容チャネル / 機械受容応答 / lysophosphatidic acid / intracellular Ca^<2+> ion concentration / in situ … More / 流れ刺激 / 血管内皮細胞 / lens epithelial cells / リゾホスファチジン / lens epithelian cells / lysophosphatide acid / intracellular CaィイD12+ィエD1 ion concentration / 高速四次元画像化法 / 共焦点レーザー走査顕微鏡 / 水晶体上皮細胞 / 細胞内カルシウムイオン濃度 / アセチルコリン / シェアストレス / 腸間膜動脈 / 収縮弛緩反応 / リゾリン脂質 / 平滑筋細胞 / 内皮細胞 / 血管 … More Except Principal Investigator 開口放出 / 抗うつ薬 / うつ病 / microarray / differential cloning / SYNAPTIC VESICLE / EXOCYTOSIS / NEUROTRANSMITTER / PRESYNAPSE / ANTIDEPRESSANT / タンパク / 小胞 / 神経伝達物質 / プレシナプス / jaw-opening muscle / jaw-closing muscle / slice preparation / patch clamp / afterhyperpolarization / motoneuron / trigeminal / 拮抗筋 / 閉口筋 / 開口筋 / スライス標本 / パッチクランプ / スパイク後過分極電位 / 運動ニューロン / 三叉神経 / exocytosis / antidepressant / neuroplasticity / depression / brain / rat / 分子生物学 / 遺伝子 / Differential Display / 神経可塑性 / 脳 / ラット / 08movement of intracellular calcium in smooth muscle cells / 07role of phosphatidic acid in contraction of smooth muscle / 05mode of contractile responses of visceral smooth muscle / 03determination of contractile responses of single muscle cells / movement of intracellular calcium in smooth muscle / role of phosphatidic acid in contraction of smooth / affinity of muscarinic receptors to agonists / mode of contractile responses of visceral smooth m / preparation of single muscle cells / determination of contractile responses of single m / Muscarinic Receptor / Smooth Muscle / 回腸縦走筋 / モルモット / ^3H-QNB / Gpp(NH)p / パパイン / コラゲナ-ゼ / 単離細胞 / 細胞内カルシウム動態 / 筋収縮でのホスファチジン酸の役割 / 受容体のアゴニスト親和性 / 平滑筋細胞の収縮様式 / 単離平滑筋細胞の調製法 / 単離筋細胞の収縮反応測定法 / ムスカリン受容体 / 平滑筋 Less

Shear stress-dependent vasospasm induced by lysophosphatidic acidPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Showa University
Effect of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University
THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
Defference in physiological and mophological properties between jaw-closing and opening motoneurons
- Principal Investigator
  
  INOUE Tomio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
THE INVESTIGATION OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEUROTRANSMITTER RELEASE
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University
Role of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
Research for functional molecule involved in mechanical stress^induced increase in CaィイD12+ィエD1 from basement membranePrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Characterization of Muscarinic Receptors in Singl Smooth Muscle Cells
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Department of Pharmacology, School of Pharmaceutical Sciences, Showa University

All 2011 2010 2006 2005 2004

All Journal Article

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx inmouse aortic endothelial cells in situ2011
- Author(s)
  H.Ohata, H.Yamada, K.Momose
- Journal Title
  
  Experimental Physiol
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Shear Stress-dependent Effects of Lysophosphatidic Acid on Agonist-induced Vasomotor Responses in Rat Mesenteric Artery2011
- Author(s)
  K. Shibata, T. Miyazaki, H. Ohata and K. Honda
- Journal Title
  
  J Cardiovascul Pharmacol
  
  Volume: 57 Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca^<2+> influx in mouse aortic endothelial cells in situ2011
- Author(s)
  H. Ohata, H. Yamada, K. Momose
- Journal Title
  
  Experimental Physiol
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx in mouse aortic endothelial cells in situ2011
- Author(s)
  Hisayuki Ohata, Hideyuki Yamada, Kazutaka Momose
- Journal Title
  
  Exp.Physiol.
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010
- Author(s)
  Miyazaki T, Honda K, Ohata H.
- Journal Title
  
  Cardiovasc Res 85
  
  Pages: 530-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces plasma exudation and histamine release in mice via LPA.2006
- Author(s)
  Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda.
- Journal Title
  
  J.Pharmacol.Sci. 100
  
  Pages: 72-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Expression of NDRG2-S and NDRG2-L after antidepressant and electroconvulsive treatment in rat frontal cortex2005
- Author(s)
  Takahashi, K., Yamada, M., Ohata, H., Higuchi, T., Yamada, M., Momose, K.
- Journal Title
  
  Int.Neuropsychopharmacol. 8
  
  Pages: 381-389
- Data Source
  KAKENHI-PROJECT-16591162
[Journal Article] Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells2005
- Author(s)
  Takahashi, K., Yamada, M., Ohata, H., Honda, K., Yamada, M.
- Journal Title
  
  Neurisci.Lett 388
  
  Pages: 157-162
- Data Source
  KAKENHI-PROJECT-16591162
[Journal Article] 流れ刺激存在下の血管内皮細胞において認められる細胞内カルシウム濃度上昇によるカルパインを介する細胞形態の制御2005
- Author(s)
  宮崎拓郎, 山本雅幸, 本田一男, 大幡久之
- Journal Title
  
  日本薬理学雑誌 126
  
  Pages: 256-261
- NAID
  10016912541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Lysophosphatidic acid induces histamine release from mast cells and skin fragments.2005
- Author(s)
  Hashimoto, T., H.Ohata, K.Momose
- Journal Title
  
  Pharmacology 75
  
  Pages: 13-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Itch-scratch response induced by lysophosphatidic acid in mice2004
- Author(s)
  Hashimoto, Terumasa, H.Ohata, K.Momose.
- Journal Title
  
  Pharmacology 72
  
  Pages: 51-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] メカノセンシタイザーとしてのリゾホスファチジン酸の役割2004
- Author(s)
  大幡久之, 他
- Journal Title
  
  日本薬理学雑誌 124
  
  Pages: 329-335
- NAID
  10014385056
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] ナカノセンシタイザーとしてのリゾホスファチジン酸の役割2004
- Author(s)
  大幡久之, 新岡丈治, 金明淑, 安藤さなえ, 山本雅幸, 百瀬和享
- Journal Title
  
  日本薬理学雑誌 124
  
  Pages: 329-335
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206

1. YAMAMOTO Masayuki (90307067)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. MOMOSE Kazutaka (80004597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. YAMADA Mitsuhiko (60240040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. FAN Yan-Il (50228855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. INOUE Tomio (70184760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAMIJIMA Kunotoshi (80051613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山上芳雄 (10220237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ohata Hisayuki 大幡 久之

OHATA Hisayuki 大幡 久之

Research Projects

Research Products

Co-Researchers

Shear stress-dependent vasospasm induced by lysophosphatidic acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defference in physiological and mophological properties between jaw-closing and opening motoneurons

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE INVESTIGATION OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEUROTRANSMITTER RELEASE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for functional molecule involved in mechanical stress^induced increase in CaィイD12+ィエD1 from basement membranePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of Muscarinic Receptors in Singl Smooth Muscle Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx inmouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] Shear Stress-dependent Effects of Lysophosphatidic Acid on Agonist-induced Vasomotor Responses in Rat Mesenteric Artery2011

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca^<2+> influx in mouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx in mouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces plasma exudation and histamine release in mice via LPA.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of NDRG2-S and NDRG2-L after antidepressant and electroconvulsive treatment in rat frontal cortex2005

Author(s)

Ohata Hisayuki 大幡久之

OHATA Hisayuki 大幡久之