OHIRA Akihiro 大平明弘

Researcher Number	00169054
Affiliation (Current)	2019: 長崎大学, 医歯薬学総合研究科(医学系), 客員教授 2019: 島根大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2018: 島根大学, 医学部, 名誉教授 2011 – 2017: 島根大学, 医学部, 教授 2003 – 2007: Shimane University School of Medicine, Professor, 医学部, 教授 2002: 島根医科大学, 医学部, 教授 1998 – 2000: Shimane Medical University, Department of Ophthalmology, Professor, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Ophthalmology / Ophthalmology / Public health/Health science / Experimental pathology
Keywords	Principal Investigator 抗酸化酵素 / 酸化ストレス / SUPEROXIDE DISMUTASE / 網膜 / 網膜光障害 / GLUTATHIONE PEROXIDASE / REACTIVE OXYGEN INTERMEDIATES / 網膜虚血 / 8-iso-prostaglandin F2α / GPX … More Except Principal Investigator 糖尿病網膜症 / 酸化ストレス / 緑内障 / VEGF / FGF / 免疫組織化学 / aquaporins / ET-1 / ET-3 / Muller細胞 / FGF-5 / epidemiological study / Aquaporin / Axonal transport / 周皮細胞 / 眼底検査 / 眼底出血 / 細胞死 / 3次元的画像解析 / 視神経 / Immunohistochemistry / 神経細胞死 / Fibroblast growth factor / Endothelins / 網膜虚血 / 歯周病菌 / 軸索輸送 / 電子顕微鏡 / Shimane, Japan / レ-ガ-走査眼底鏡 / Growth factors / 軟性白斑 / 血管内皮増殖因子 / vascular endothelial growth factor / Behcet's disease / ET_A receptor / 口腔内細菌 / Thioredoxin / MUTANT / チュニジア / ETB受容体 / 視野 / AMSマウス / 抗酸化 / ルテイン / ぶどう膜炎 / Oxidative Stress / 軌索輸送 / ミュータント / immunohistochemistry / Cotton wool spot / 成長因子 / Race / 臨床像 / retinal edema / Aquaporin-4 / APOPTOSIS / トランスフェクション / Japan / 光学顕微鏡 / Retinal nerve fiber layer defect / 翼状片 / Pterygium / 網膜 / 黄斑色素 / Age-related macular degeneration / CEREBELLAR ATAXIA / レ-ザ-走査眼底鏡 / ET_A受容体 / アポトーシス / CASPASE / Retinal Microvessel / チオレドキシン / ETA受容体 / 眼底写真 / neurotransmitter / 病理学 / Optic disc / 加齢黄斑変性 / ET_B受容体 / Glaucoma / 網膜神経線維層欠損 / 網膜毛細血管 / subretinal vascular membrane / 加齢性黄斑変性症 / 視神経乳頭 / K^+Channel / Uveitis / 画像解析 / AMS MOUSE / 3-dimensional image analysis / Nnal GENE / Diabetic retinopathy / Scanning laser Ophthalmoscope / 人種 / 増殖性硝子体網膜症 / 虫歯菌 / 点突然変異 / 日本 / ベーチェット病 / proliferative vitreoretinopathy / プルキンエ細胞 / Pericyte / エンドセリン / Nna1遺伝子 / NEURAL CELL DEATH / PURKINJYE CELL / 網膜浮腫 / コホート研究 / 小脳性失調症 / retinal photograph / ET_B receptor / 疫学研究 / 網膜下新生血管 / 線維芽細胞増殖因子 / 島根県 / Visual field / Tunisia / Nnal遺伝子 Less

ルテイン投与による還元型チオール増加を介した抗酸化能力の増強Principal InvestigatorOngoing
- Principal Investigator
  
  大平明弘
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Shimane University
口腔内細菌による眼底出血誘発の可能性とそのメカニズムOngoing
- Principal Investigator
  
  原克典
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Assessment of oxidative stress in samples from glaucoma patients
- Principal Investigator
  
  TANITO MASAKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Clinical and basic examination of the macula pigment for the macula function
- Principal Investigator
  
  Koyama Yasurou
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Inspection of a change and the lutein effect in the living body of singlet oxygen derived from the light exposure using the new lipid oxidation markerPrincipal Investigator
- Principal Investigator
  
  Ohira Akihiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Drug response biomarker genes of ocular hypotensives
- Principal Investigator
  
  TANITO Masaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout MicePrincipal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
The development of new retinal oxidative stress market and the effects of vitamin E intensive care against retinal light damagePrincipal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
ANALYSIS OF FUNCTION OF THE DISEASE-RESPONSIBLE GENIE Nnal FOR A MUTANT MOUSE EXHIBITING CEREBELLAR ATAXIA AND MALE STERILITY
- Principal Investigator
  
  HARADA Takayuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shimane University
Thioredoxin Protects Retinal Microvascular Cell Injury Caused By Hydrogen Peroxide
- Principal Investigator
  
  KODAMA Tatsuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Epidemiological study of diabetic retinopathy in Shimane, Japan
- Principal Investigator
  
  FUJITA Yasuyuki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Shimane University
  Shimane Medical University
Study on Molecular Mechanism and Therapy of Light-induce Retinal DamagePrincipal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University School of Medicine
Cytoprotection of prostaglandin under oxidative stressPrincipal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane Medical University
Analysis of the mechanism of retinal edema by the membrane potential and water channel proteins of Muller cell
- Principal Investigator
  
  SHIBUYA Yuzo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane Medical University
Defense mechanism for age-related macular degeneration.Principal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane Medical University
  Nagasaki University
Distribution and function of fibroblast growth factor in the retina and the epiretinal membrane.
- Principal Investigator
  
  KITAOKA Takashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nagasaki University
Alteration of Endothelins expression in the normal and pathologic retina
- Principal Investigator
  
  TSUDA Yasuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  NAGASAKI UNIVERSITY
Defense mechanism for retinal light damage.Principal Investigator
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nagasaki University
Pterygium and Behcet's disease between Japan and Tunisia
- Principal Investigator
  
  AMEMIYA Tsugio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagasaki University
網膜虚血再〓流における過酸化脂質の産生と・その治療に関する研究Principal Investigator
- Principal Investigator
  
  大平明弘
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nagasaki University
  Kyoto University
Parameters associated with vulnerability of nerve fibers to glaucomatous damage.
- Principal Investigator
  
  CHIHARA Etsuo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyoto University

All 2016 2015 2007 2006 2005

All Journal Article Presentation

[Journal Article] Association between systemic oxidative stress and visual field damage in open-angle glaucoma.2016
- Author(s)
  Tanito M, Kaidzu S, Takai Y, Ohira A.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 25792-25792
- DOI
  10.1038/srep25792
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10866
[Journal Article] Correlation between Systemic Oxidative Stress and Intraocular Pressure Level2015
- Author(s)
  Masaki Tanito, Sachiko Kaidzu, Yasuyuki Takai, Akihiro Ohira
- Journal Title
  
  PLOS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0133582
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10866
[Journal Article] Acceleration of Age-Related Changes in the Retina in a -Tocopherol Transfer Protein Null Mice Fed a Vitamin E-Deficient Diet.2007
- Author(s)
  Masaki, Tanito, Yasukadu, Yoshida, Sachiko, Kaidzu, Zhi-Hua, Chen, Osamu, Cynshi, Kou-ichi, Jishage, Etsuo, Niki, Akihiro, Ohira
- Journal Title
  
  Investigative Ophthalmology & Vision Science 48 (1)
  
  Pages: 396-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591921
[Presentation] Correlation between systemic oxidative stresses and intraocular pressure level.2015
- Author(s)
  Tanito M, Kaidzu S, Takai Y, Ohira A
- Organizer
  ARVO 2015 Annual Meeting
- Place of Presentation
  Denver, CO (アメリカ）
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10866
[Presentation] 神経・雄性生殖器系ミュータントamsマウス:14網膜視細胞のアポトーシス感受性の亢進.2006
- Author(s)
  荒木亜寿香, 周麗, 中野晃伸, 大平明弘, 原田孝之
- Organizer
  第95回日本病理学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590347
[Presentation] Effeet of the ems mutation in the Ataxia and Male Sterility (AMS) mouse on photic injury to photoreceptor cells2006
- Author(s)
  Asuka, Araki, Akinobu, Nakano, Li, Zhou, Riruke, Maruyama, Akihiro, Ohira, Takaybki, Harada
- Organizer
  The Seventh Joint Meeting of the Japan Society of Histochemistry and Cytochemistry and the US Histochemical Society. Waikoloa
- Place of Presentation
  Hawaii
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590347
[Presentation] Neural and Male Germ Cell Mutant AMS Mouse : 14. Acceleration of sensitivity to apoptosis of photoreceptor cells of the AMS retina2006
- Author(s)
  Asuka, Araki, Li, Zhou, Akinobu, Nakano, Akihiro, Ohira, Takayuki, Harada
- Organizer
  95th Annual Meeting of the Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590347
[Presentation] Acceleration of age-related changes in retinal structure and biochemistry in vitamin E deficient diet-fed α-tocopherol transfer protein null mice2006
- Author(s)
  Masaki, Tanito, Yasukazu, Yoshida, Sachiko, Kaidzu, Etsuo, Niki, Akihiro, Ohira
- Organizer
  XIIth International Symposium on Retinal Degeneration Algentina (San Carlos de Bariloche)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591921
[Presentation] Effect of the ams mutation in the Ataxia and Male Sterility (AMS) mouse on photic injury to photoreceptor cells.2006
- Author(s)
  Asuka Araki, Akinobu Nakano, Li Zhou, Riruke Maruyama, Akihiro Ohira and Takayuki Harada
- Organizer
  The Seventh Joint Meeting of the Japan Society of Histochemistry and Cytochemistry and the US Histochemical Society.
- Place of Presentation
  Waikoloa, Hawaii
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590347
[Presentation] Neural and Male GermCell Mutant : AMS Mouse : 41. Acceleration of the PhOtoieceptot Cell Death by Photic Injury in AMS Retina2005
- Author(s)
  Li, Zhbu, Asuka, Araki, AkinobuNakano, Yu, Ryu, Akihiro, Ohira, lakayuki, Harada
- Organizer
  46th AnnOrMeatina of the Japanese Society forthStoebeinittrYand-Cytochemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590347
[Presentation] 神経・雄性生殖系ミュータントAMSマウス:11.光刺激による網膜視細胞死の促進2005
- Author(s)
  周麗, 荒木亜寿香, 中野晃伸, 柳勇, 大平明弘, 原田孝之
- Organizer
  第46回日本組織細胞化学会
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590347

1. KAIDZU Sachiko (00325052)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
2. TANITO Masaki (30284037)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. KODAMA Tatsuo (60215283)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
4. TSUDA Yasuo (30253660)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. SHIBUYA Yuzou (20196455)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KITAOKA Takashi (80234235)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 嵩義則 (30244049)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. HARA Katsunori (00609323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Yoshida YASUKAZU (90358333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TANE Nobuhiro (50277993)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MASUDA Hisashi (80304278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 和田孝一郎 (90263467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OKUNO Tsutomu (90332395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YASUYUKI Takai (20397871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Koyama Yasurou (60325058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. CHIHARA Etsuo (20111958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKINAMI Satoshi (70089100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AMEMIYA Tsugio (60026862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKANASHI Taiji (10226798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. FUJITA Yasuyuki (70173440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TANIHARA Shinichi (40285771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. AMANO Hiroki (80293033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HARADA Takayuki (90112135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
25. NAKANO Akinobu (70263514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
26. NONOYAMA Shin (30362924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. UMENO Aya (20749098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 吉村長久 (70211662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 臼田春樹 (30707667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SARRA Ben jilani

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. OIERTANI Awe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. OUERTANI Amel meddeb

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. BEN Jilani S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. OUERTANI Ame

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHIRA Akihiro 大平 明弘

Research Projects

Research Products

Co-Researchers

ルテイン投与による還元型チオール増加を介した抗酸化能力の増強Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔内細菌による眼底出血誘発の可能性とそのメカニズムOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inspection of a change and the lutein effect in the living body of singlet oxygen derived from the light exposure using the new lipid oxidation markerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of new retinal oxidative stress market and the effects of vitamin E intensive care against retinal light damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Molecular Mechanism and Therapy of Light-induce Retinal DamagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cytoprotection of prostaglandin under oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

OHIRA Akihiro 大平明弘