SAKAI Takashi 酒井貴志

Researcher Number	00170556
Other IDs
Affiliation (based on the past Project Information) *help	1999 – 2004: Okayama University, Faculty of Engineering, Professor, 工学部, 教授 1993 – 1998: Department of Applied Chemistry, Associate Professor, 工学部, 助教授 1992: 岡山大学, 大学院櫟然科学研究科, 助手 1990 – 1991: 岡山大学, 工学部, 助手 1988: Faculty of Engineering, Okayama University, 工学部, 助手
Review Section/Research Field	Principal Investigator Synthetic chemistry / 有機工業化学 Except Principal Investigator Synthetic chemistry / Synthetic chemistry / Synthetic chemistry / 有機工業化学
Keywords	Principal Investigator リパーゼ / 不斉合成 / 光学活性 / asymmetric synthesis / フッ素 / アジリン / enzyme / 架橋剤 / 酵素 / lipase … More / optically active / アジリジン / basicity / asymmetric catalysis / fluorine / immobilized lipase / kinetic resolution / ceramic / 不斉配位子 / 分子間相互作用 / 固定化触媒 / 塩基性 / 不斉触媒 / 固定化リパーゼ / 速度論的分割 / セラミックス / aziridine / low-temperature reaction / amino acid / azirine / アミノアルコール / 固定化酵素 / 低温反応 / アミノ酸 / bakers' yeast / reductase / subtilisin / biocatalyst / chiral / キラル / アルコール / 光学分割 / パン酵母 / 不斉還元 / 生体触媒 / ニトリル / ヒドロキシ / アミン / オキサザボロリジン / C2対称化合物 / ルイス酸 … More Except Principal Investigator 不斉還元 / 光学分割 / リパーゼ / パン酵母 / パン酵母還元 / optically active / lipase / 光学活性 / 生体触媒 / Electrolysis / Fluorination / Fluoro-compound / トリフルオロメチル化 / フッ素化 / フッ素化合物 / トリフルオロメチル / トリフルオロメチルインドール / Asymmetric synthesis of both enantiomers / Optically active 2,4,4-trichlorobutanoic acid / Optically active -chloro acids / α-クロローα, β-不飽和エステル / α-アミノ酸 / 光学活性α-ハロエステル / クラウンゴール / ロイシノピンアナログ / 両鏡像体合成 / アルメントマイシン / 光学活性2、4、4ートリクロロブタン酸 / 光学活性αークロロカルボン酸 / Asymmetric reduction / Kinetic resolution / Enantioselectivity / High temperature / Immobilization / Lipase / Enzyme / Biocatalyst / 超臨界二酸化炭素 / エナンチオ選択性 / 高温 / 固定化 / 酵素 / amino alcohol / diol / fluorine / 分子間相互作用 / アミノアルコール / ジオール / フッ素 / biocatalyst / asymmetric reduction / reductase / bakers'yeast / 還元酵素 / optically active chlorohydrins / optically active alpha -acetoxy alcohols / trifunctional chiral synthons / Bakers' yeast asymmetric reduction / optically active gamma -substituted beta -hydroxy ketones / キラルシントン / 位置選択的還元 / 1.3-ジケトン / 1-アセトキシ-2,4-アルカンジオン / α-アセトキシケトン / 1,3-ジケトン / 光学活性1,2-ジオール誘導体 / 多官能性キラルシントン / 光学活性クロロヒドリン / 光学活性α-アセトキシアルコール / 光学活性β-ヒドロキシケトン / パン酵母不斉還元 / トリフルオロアセトイミドイル / キノロンカルボン酸 / いもち病 / トリフルオロメチルベンゾイミダゾール / スピロジアザカルボサイクル / 電解酸化 / トリフルオロ酢酸 / イミドイルハライド / 電気化学的酸化 / インドール / beta-Chloro delta-Hydroxy Esters / beta-Hydroxy delta-Lactones / beta-Keto delta-Lactones / beta-Chloro gamma-Keto Esters / beta-Chloro gamma-Keto Acids / beta, delta-Diketo Acids / Bakers' Yeast Reduction / Asymmetric Reduction / 塩化マンガン添加物 / NADPH依存性 / 酸化還元酵素 / 光学活性δーラクトン / δーケト酸 / βークロローγーヒドロキシエステル / βーヒドロキシーδーラクトン / βーケトーδークラトン / βークロローγーケトエステル / βークロロ γーケト酸 / βークロロγーヒドロキシエステル / βーヒドロキシδーラクトン / βーケトδーラクトン / βークロロγーケトエステル / βークロロγーケト酸 / β,δージケト酸 / アゾ化合物 / トリフルオロメチルキノリン / ハロゲン化イミドイル / トリフルオロアラニン Less

Development of Biocatalysts Using Organized Nano-reactors
- Principal Investigator
  
  EMA Tadashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  OKAYAMA UNIVERSITY
Development of Porous Ceramic-Immobilized Lipase Catalyst and Optically Active Fluorinated supramoleculesPrincipal Investigator
- Principal Investigator
  
  SAKAI Takashi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  OKAYAMA UNIVERSITY
Efficient Preparation of Optically Active Highly Strained Azirines and Synthesis of Natural and Unnatural Amines and Amino AcidsPrincipal Investigator
- Principal Investigator
  
  SAKAI Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  OKAYAMA UNIVERSITY
Synthesis of Optically Active Compounds Having Pentafluorophenyl Group - The Structure and Function
- Principal Investigator
  
  UTAKA Masanori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
Efficient Synthesis of New Chiral Synthons by Artificial Regulation of Biocatalysis and Development of Optically Active DrugsPrincipal Investigator
- Principal Investigator
  
  SAKAI Takashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
光学活性非天然型アミン類の新規合成法の開発と応用Principal Investigator
- Principal Investigator
  
  酒井貴志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
Synthesis of Multi-functional Chiral Molecules by Developing the Function of Biocatalysts
- Principal Investigator
  
  UTAKA Masanori
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
含フッ素有機典型金属活性種の創製と反応
- Principal Investigator
  
  UNEYAMA Kenji
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
フッ素で機能化された光学活性有機金属反応剤の開発Principal Investigator
- Principal Investigator
  
  酒井貴志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  有機工業化学
- Research Institution
  Okayama University
Active Fluoro-intermediate for Fluorinated Heterocycles
- Principal Investigator
  
  UNEYAMA Kenji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
Drug Design of Fluorinated Quinolone Carboxylic Acid Related Compounds and the Test of Biological Activities.
- Principal Investigator
  
  UNEYAMA Kenji
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  Okayama University
Regio- and Stereoselective Reduction of Substituted 1.3-Dicarbonyl Compounds by Use of Bakers' Yeast
- Principal Investigator
  
  UTAKA Masanori
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
Asymmetric Reduction of Keto Acids by Use of Bakers' Yeast
- Principal Investigator
  
  UTAKA Masanori
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University
Asymmetric Synthesis and Use of
- Principal Investigator
  
  UTAKA Masanori
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Okayama University

All 2005 2004 2003 Other

All Journal Article

[Journal Article] Lipase-Catalyzed Resolution of (2R^*,3S^*)- and (2R^*,3R^*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.2005
- Author(s)
  Sakai, T., Lin, Y., Ohta, H., Korenaga, T., Ema, T.
- Journal Title
  
  The Journal of Organic Chemistry 70・4
  
  Pages: 1369-1375
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] Lipase-Catalyzed Resolution of (2R^*,3S^*)- and (2R^*,3R^*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stere oisomers.2005
- Author(s)
  Sakai, T., Liu, Y., Ohta, H., Korenaga, T., Ema, T.
- Journal Title
  
  The Journal of Organic Chemistry 70
  
  Pages: 1369-1375
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] Lipase-Catalyzed Resolution of (2R^*,3S^*)-and (2R^*,3R^*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.2005
- Author(s)
  Sakai, T., Liu, Y., Ohta, H., Korenaga, T., Ema, T.
- Journal Title
  
  The Journal of Organic Chemistry 70
  
  Pages: 1369-1375
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] Asymmetric Reduction of a Variety of Ketones with a Recombinant Carbonyl Reductase : Identification of the Gene Encoding a Versatile Biocatalyst.2005
- Author(s)
  Ema, T., Yagasaki, H., Okita, N., Nishikawa, K., Korenaga, T., Sakai, T.
- Journal Title
  
  Tetrahedron : Asymmetry 16
  
  Pages: 1075-1078
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] The Effect of Temperature on the Lipase-Catalyzed Asymmetric Protonation of 1-Acetoxy-2-methylcyclohexene Giving (R)-2-Methylcyclohexanone.2004
- Author(s)
  Sakai, T., Matsuda, A., Tanaka, Y., Korenaga, T., Ema, T.
- Journal Title
  
  Tetrahedron : Asymmetry 15・12
  
  Pages: 1929-1932
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] The Effect of Temperature on the Lipase-Catalyzed Asymmetric Protonation of 1-Acetoxy-2-methylcyclohexene Giving (R)-2-Methylcyclohexanone.2004
- Author(s)
  Sakai, T., Matsuda, A., Tanaka, Y., Korenaga, T., Ema, T.
- Journal Title
  
  Tetrahedron : Asymmetry 15
  
  Pages: 1929-1932
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] Highly Enantioselective Lipase-Catalyzed Reactions at High Temperatures up to 120℃ in Organic Solvent.2003
- Author(s)
  Ema, T., Kageyama, M., Korenaga, T., Sakai, T.
- Journal Title
  
  Tetrahedron : Asymmetry 14
  
  Pages: 3943-3947
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550093
[Journal Article] Asymmetric Reduction of a Variety of Ketones with a Recombinant Carbonyl Reductase : Identification of the Gene Encoding a Versatile Biocatalyst.
- Author(s)
  Ema, T., Yagasaki, H., Okita, N., Nishikawa, K., Korenaga, T., Sakai, T.
- Journal Title
  
  Tetrahedron : Asymmetry (印刷中)
- Data Source
  KAKENHI-PROJECT-15550093

1. UTAKA Masanori (30033153)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. EMA Tadashi (20263626)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
3. UNEYAMA Kenji (00033150)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TSUBOI Sadao (00032954)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KORENAGA Toshinobu (70335579)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. MINAI Masayoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YASUI Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKAI Takashi 酒井 貴志

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Porous Ceramic-Immobilized Lipase Catalyst and Optically Active Fluorinated supramoleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Efficient Preparation of Optically Active Highly Strained Azirines and Synthesis of Natural and Unnatural Amines and Amino AcidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

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Efficient Synthesis of New Chiral Synthons by Artificial Regulation of Biocatalysis and Development of Optically Active DrugsPrincipal Investigator

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Research Institution

光学活性非天然型アミン類の新規合成法の開発と応用Principal Investigator

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フッ素で機能化された光学活性有機金属反応剤の開発Principal Investigator

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Research Institution

Principal Investigator

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[Journal Article] Lipase-Catalyzed Resolution of (2R^*,3S^*)- and (2R^*,3R^*)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.2005

Author(s)

SAKAI Takashi 酒井貴志

[Journal Article] Lipase-Catalyzed Resolution of (2R^,3S^)- and (2R^,3R^)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.2005

[Journal Article] Lipase-Catalyzed Resolution of (2R^,3S^)- and (2R^,3R^)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stere oisomers.2005

[Journal Article] Lipase-Catalyzed Resolution of (2R^,3S^)-and (2R^,3R^)-3-Methyl-3-phenyl-2-aziridinemethanol at Low Temperatures and Determination of the Absolute Configurations of the Four Stereoisomers.2005