ECHIZEN Hirotoshi 越前宏俊

Researcher Number	00191924
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2010: 明治薬科大学, 薬学部, 教授 2002 – 2004: 明治薬科大学, 薬学部, 教授 1995 – 1997: MEIJI COLLEGE OF PHARMACY PROFESSOR, 薬学部, 教授 1994: 北里大学, 医学部, 講師
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Laboratory medicine Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator CYP3A / 6β-hydroxycortisol / partial metabolic clearance / cortisol / lansoprazole / drug interaction / Helicobacter pylori / cytochrome P450 / clarithromycin / 6β水酸化コルチゾール … More / 部分代謝クリアランス / コルチゾール / ランソプラゾール / 薬物相互作用 / ヘリコバクターピロリ菌 / シトクロームP450 / クラリスロマイシン / Enantiomers / disopyramide / Human liver microsomes / キラル / 光学異性体 / ミクロゾーム / ジソピラミド / ステロイド / LC-MS / ステロイドホルモン / 個人差 / 薬物代謝 / 代謝欠損 / 副作用 / 遺伝多型 / チトクロームP450 … More Except Principal Investigator CYP4F23 / VKORC12 / 投与前凝固活性 / 抗凝固効果 / INR / 遺伝子多型 / VKORC1 / CYP2C9 / 応答性 / 個体差 / ワルファリン Less

Individualization of anticoagulation therapy of warfarin based on pharmacogenetic information
- Principal Investigator
  
  TAKAHASHI Harumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Meiji Pharmaceutical University
Studies on the urinary assay of CYP-mediated endogenous corticosteroid metabolites with a LC-MS methodPrincipal Investigator
- Principal Investigator
  
  ECHIZEN Hirotoshi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Meiji Pharmaceutical University
Inhibition of CYP3A activity by a standard triple drug regimen including clarithromycin for eradication of Helicobacter pylori infectionPrincipal Investigator
- Principal Investigator
  
  ECHIZEN Hirotoshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Meiji Pharmaceutical University
肝薬物代謝酵素欠損症の遺伝子診断手法を用いた副作用モニタリング・システムの確立Principal Investigator
- Principal Investigator
  
  越前宏俊
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Meiji Pharmaceutical University
CYP3A ISOFORMS MEDIATED ENANTIOSELECTIVE DRUG METABOLISM WITH HUMAN LIVER MICROSOMESPrincipal Investigator
- Principal Investigator
  
  ECHIZEN Hirotoshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  MEIJI COLLEGE OF PHARMACY
  Kitasato University

All 2010 2009 2008 2007 2006 2004 2003 2002

All Journal Article Presentation Book

[Book] 医療薬物代謝学2010
- Author(s)
  越前宏俊
- Publisher
  医学評論社
- Data Source
  KAKENHI-PROJECT-18590542
[Book] 医療薬物代謝学2009
- Author(s)
  越前宏俊(分担執筆)
- Total Pages
  187
- Publisher
  医学評論社
- Data Source
  KAKENHI-PROJECT-18590542
[Book] 最新創薬学2007臨床薬物動態の実戦-トランスレーショナルPKIPD研究:ワルファリン2007
- Author(s)
  高橋晴美、越前宏俊
- Total Pages
  15
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Urinary Lipocalin-Type Prostaglandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009
- Author(s)
  Nakayama H, Echizen H, et al.
- Journal Title
  
  Ther Drug Monit 32
  
  Pages: 126-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Urinary Lipocalin Type Prosta- glandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009
- Author(s)
  Nakayama H, Echizen H, Gomi T, Shibuya Y, Nakamura Y, Nakano K, Arashi H, Ohnishi S, Tanaka M, Orii T
- Journal Title
  
  Ther Drug Monit 32
  
  Pages: 126-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] A Novel Microsatellite Polymorphism of Sodium Channel β1-Subunit Gene(SCN1B)May Underlie Abnormal Cardiac Excitation Manifested by Coved-type ST-elevation Compatible With Brugada Syndrome in Japanese2009
- Author(s)
  Ogawa R, Kishi R, Takagi A, Sakaue I, Takahashi H, Matsumoto N, Echizen H
- Journal Title
  
  Int J Clin Pharmacol Ther 48
  
  Pages: 109-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Urinary Lipocalin-Type Prostaglandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009
- Author(s)
  Nakayama H, Echizen H, Gomi T, Shibuya Y, Nakamura Y, Nakano K, Arashi H, Ohnishi S, Tanaka M, Orii T
- Journal Title
  
  Ther Drug Monit 32
  
  Pages: 126-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Reduced vancomycin clearance despite unchanged creatinine clearance in patients treated with vancomycin for longer than 4 weeks2008
- Author(s)
  Nakayama H, Echizen H, Tanaka M, Sato M, Orii T
- Journal Title
  
  Ther Drug Monit 30
  
  Pages: 103-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Bioequivalence studies between 0.5, 1, and 5 mg warfarin potassium tablets of new formula and those of standard formula2008
- Author(s)
  Dochiguchi Y, Shiba S, Masuda Y, Kurihara Y, Hasegawa S, Echizen H
- Journal Title
  
  Jpn Pharmacol Ther 36
  
  Pages: 401-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] A meta-analysis on the risk of developing malignancy associated with use of immunosuppressive agents in patients with inflammatory bowel disease2007
- Author(s)
  Masunaga Y, Ohno K, Ogawa R, Hashiguchi M, Echizen H, Ogata H
- Journal Title
  
  Ann Pharmacother 41
  
  Pages: 21-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] A meta-analysis on the risk of developing malignancy associated with use of immunosunnressive agents in natients with inflammatory bowel disease2007
- Author(s)
  Masunaga Y, Ohno K, Ogawa R, Hashiguchi M, Echizen H, Ogata H
- Journal Title
  
  Ann Pharmacother 41
  
  Pages: 21-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Proteomic & Transcriptomic Analyses of Retinal Pigment Epithelial Cells Exposed t-o REF-1/TFPI-2, a Growth Promoting Factor2007
- Author(s)
  Shibuya M, Okamoto H, Nozawa T, Utsumi J, Reddy VN, Echizen H, Tanaka Y, Iwata T.
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 516-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Effect of low-dose macrolide antibiotics on theophylline disposition in pediatric patients2007
- Author(s)
  Abe Y, Nanri Y, Oto H, Kitabayashi T, Watanabe S, Odajima Y, Itabashi K, Takahashi H, Echizen H
- Journal Title
  
  日本小児呼吸器疾患学会誌 18
  
  Pages: 7-13
- NAID
  10019544744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Proteomic & Transcriptomic Analyses of Retinal Pigment Epithelial Cells Exposed t-o REF-1/TFPI-2,a Growth Promoting Factor2007
- Author(s)
  Shibuya M, Okamoto H, Nozawa T, Utsumi J, Reddy VN, Echizen H, Tanaka Y, Iwata T.
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 516-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Proteomic ＆ Transcriptomic Analyses of Retinal Pigment Epithelial Cells Exposed to REF-1/TFPI-2, a Growth Promoting Factor2007
- Author(s)
  Shibuya M, Okamoto H, Nozawa T, Utsumi J, Reddy VN, Echizen H, Tanaka Y, Iwata T.
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 516-521
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Effect of low-dose macrolide antibiotics on the ophylline disposition in pediatric patlents2007
- Author(s)
  Abe Y, Nanri Y, Oto H, Kitabayashi T, Watanabe S, Odajima Y, Itabashi K, Takahashi H, Echizen H
- Journal Title
  
  日本小児呼吸器疾患学会誌 18
  
  Pages: 7-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] CYPの遺伝多型と抗不整脈薬2006
- Author(s)
  越前宏俊
- Journal Title
  
  Jpn J Electrocardiol 26
  
  Pages: 195-200
- NAID
  10019171937
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African Americans2006
- Author(s)
  Takahashi, H, Wilkinson, GR, Nutescu, EA, Morita, T, Ritchie, M, Scordo, MG, Pengo, V, Barban, M, Padrini, R, Ieiri I, Otsubo, K, Kashima T, Kimura S, Kijima S, Echizen H
- Journal Title
  
  Pharmacogenetics &amp ; Genomics 16
  
  Pages: 101-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic, Pilsicainide, in Patients with Cardiac Arrhythmias2006
- Author(s)
  Ogawa, R, Kishi, R, Mihara, K, Takahashi, H, Takagi, A, Matsumoto, N, Masuhara, K, Nakazawa, K, Miyake, F, Kobayashi, S, Echizen, H.
- Journal Title
  
  J Clin Pharmaol 46
  
  Pages: 59-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] 個別化されたワルファリン療法への道2006
- Author(s)
  越前宏俊
- Journal Title
  
  日本血栓止血学会誌 17
  
  Pages: 430-433
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African Americans2006
- Author(s)
  Takahashi, H, Wilkinson, GR, Nutescu, EA, Morita, T, Ritchie, M, Scordo, MG, Pengo, V, Barban, M, Padrini, R, Ieiri I, Otsubo, K, Kashima T, Kimura S, Kijima S, Echizen H
- Journal Title
  
  Pharmacogenetics ＆ Genomics 16
  
  Pages: 101-110
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra-and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African Americans.2006
- Author(s)
  Takahashi, H, Wilkinson, GR, Nutescu, EA, Morita, T, Ritchie, M, Scordo, MG, Pengo, V, Barban, M, Padrini, R, Ieiri I, Otsubo, K, Kashima T, Kimura S, Kijima S, Echizen H
- Journal Title
  
  Pharmacogenetics & Genomics 16
  
  Pages: 101-110
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic, Pilsicainide, in Patients with Cardiac Arrhythmias.2006
- Author(s)
  Ogawa, R, Kishi, R, Mihara, K, Takahashi, H, Takaga, A, Matsumoto, N, Masuhara, K, Nakazawa, K, Miyake, F, Kobayashi, S, Echizen,H.
- Journal Title
  
  J Clin Pharmaol 46
  
  Pages: 59-68
- Data Source
  KAKENHI-PROJECT-18590542
[Journal Article] 医薬品の相互作用:その虚像と実像・科学的実証を求めて2004
- Author(s)
  越前宏俊
- Journal Title
  
  臨床薬理 35
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] The in vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in man.2003
- Author(s)
  Junji Saruwatari, Kazuko Nakagawa, Junichi Shindo, Shinobu Nachi, Hitotoshi Echizen, Takashi Ishizaki
- Journal Title
  
  J Pharm Pharmacol 55
  
  Pages: 1553-1559
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] Reduced urinary 6b-hydroxycortisol to cortisol rations in patients with liver cirrhosis2003
- Author(s)
  Shibuya Masahiko, Hirotoshi Echizen, Suzuko Kubo, Noboru Tamura, Koichi Suzuki, Hideki Ushiama, Akihiko Ohnishi
- Journal Title
  
  Hepatol Res 26
  
  Pages: 28-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] 標準的3剤併用ヘリコバクターピロリ菌除菌療法におけるクラリスロマイシンの投与量依存的CYP3A阻害作用2003
- Author(s)
  越前宏俊, 牛尼秀樹, 大西明弘
- Journal Title
  
  臨床薬理 34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] The in vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (A2 and 3A) and xanthine oxidase in man2003
- Author(s)
  Saruwatari J, Nakagawa K, Shindo J, Nachi S, Echizen H, Ishizaki T
- Journal Title
  
  J Pharm Pharmacol 55
  
  Pages: 1553-1559
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in lansoprazole levels and partial cortisol clearance to 6(β-hydroxycortisol2002
- Author(s)
  Ushiama H, Echizen H, Nachi S, Ohnishi A
- Journal Title
  
  Clin Pharmacol Ther 72
  
  Pages: 33-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Journal Article] Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobactoer Pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6b-hydroxycortisol2002
- Author(s)
  Hideki Ushiama, Hirotoshi Echizen, Shinobu Nachi, Akihiro Ohnishi
- Journal Title
  
  Clin Pharmacol Ther 72
  
  Pages: 33-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572166
[Presentation] ワルファリンによる抗凝固効果のコントロールに及ぼす投与前凝固活性の個体差と臨床的影響2010
- Author(s)
  市村洋介、高橋晴美、MTM Lee、YT Chen、塩見真理、森田隆司、越前宏俊
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590548
[Presentation] 白癬患者に対するイトラコナゾールパルス療法施行時のCYP3A活性の経時的変化2009
- Author(s)
  柴田壮一、高橋晴美、小野紀子、和田直子、久保博昭、篠崎公一、齋藤京、稲本伸子、越前宏俊、厚田幸一郎
- Organizer
  日本臨床薬理学会第30回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18590542
[Presentation] 爪白癬症に対するイトラコナゾールパルス療法施工時のCYP3A活性の経時的変化2009
- Author(s)
  柴田壮一、高橋晴美、小野紀子、和田直子、久保博昭、篠崎公一、齊藤京、稲本伸子、越前宏俊、厚田幸一郎
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590548
[Presentation] 癌化学療法の急性悪心・嘔吐に対するメチルプレドニゾロンとデキサメタゾンの予防効果の比較2008
- Author(s)
  橋本佳奈、小川竜一、高橋晴美、井上正広、越前宏俊
- Organizer
  第18回日本医療薬学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590548
[Presentation] イリノテカン塩酸塩により誘発される遅発性下痢に対する予防法の有効性に関するメタ解析2008
- Author(s)
  高井佐知子、小川竜一、高橋晴美、堀治、越前宏俊
- Organizer
  第18回日本医療薬学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590548
[Presentation] 内因性N^-メチルニコチンアミドおよびL^-カルニチンによる腎尿細管トランスポーター活性評価の試み2008
- Author(s)
  小川竜一、越前宏俊
- Organizer
  医療薬学フォーラム2008
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-18590542
[Presentation] 閉経後骨粗鬆症患者に対する経口ビスホスフォネートとラロキシフェンの効果と安全性の比較に関するメタ解析2008
- Author(s)
  高地恵市、小川竜一、高橋晴美、後藤一美、越前宏俊
- Organizer
  第18回日本医療薬学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590548
[Presentation] Population differences in the contribution of genetic polymolphism of phamlacoki netics/phaarmacodynamics toward drug response2007
- Author(s)
  Echizen H
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590542
[Presentation] 内因性N^1-メチルニコチンアミドの腎クリアランスによる腎有機カチオントランスポーター活性の評価2007
- Author(s)
  小川竜一、越前宏俊
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  宇都宮
- Year and Date
  2007-11-12
- Data Source
  KAKENHI-PROJECT-18590542

1. OHNISHI Akihiro (00194225)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. TAKAHASHI Harumi (20211344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. GOTO Shinya (50225653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ISHIZAKI Takashi (50158747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 古家恵子 (10277733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ECHIZEN Hirotoshi 越前 宏俊

Research Projects

Research Products

Co-Researchers

Individualization of anticoagulation therapy of warfarin based on pharmacogenetic information

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the urinary assay of CYP-mediated endogenous corticosteroid metabolites with a LC-MS methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of CYP3A activity by a standard triple drug regimen including clarithromycin for eradication of Helicobacter pylori infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝薬物代謝酵素欠損症の遺伝子診断手法を用いた副作用モニタリング・システムの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CYP3A ISOFORMS MEDIATED ENANTIOSELECTIVE DRUG METABOLISM WITH HUMAN LIVER MICROSOMESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医療薬物代謝学2010

Author(s)

Publisher

Data Source

[Book] 医療薬物代謝学2009

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新創薬学2007臨床薬物動態の実戦-トランスレーショナルPKIPD研究:ワルファリン2007

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Urinary Lipocalin-Type Prostaglandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009

Author(s)

Journal Title

Data Source

[Journal Article] Urinary Lipocalin Type Prosta- glandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009

Author(s)

Journal Title

Data Source

[Journal Article] A Novel Microsatellite Polymorphism of Sodium Channel β1-Subunit Gene(SCN1B)May Underlie Abnormal Cardiac Excitation Manifested by Coved-type ST-elevation Compatible With Brugada Syndrome in Japanese2009

Author(s)

Journal Title

Data Source

[Journal Article] Urinary Lipocalin-Type Prostaglandin D Synthase : A Potential Marker for Early Gentamicin-Induced Renal Damage?2009

Author(s)

Journal Title

Data Source

[Journal Article] Reduced vancomycin clearance despite unchanged creatinine clearance in patients treated with vancomycin for longer than 4 weeks2008

Author(s)

Journal Title

Data Source

[Journal Article] Bioequivalence studies between 0.5, 1, and 5 mg warfarin potassium tablets of new formula and those of standard formula2008

Author(s)

Journal Title

Data Source

[Journal Article] A meta-analysis on the risk of developing malignancy associated with use of immunosuppressive agents in patients with inflammatory bowel disease2007

Author(s)

Journal Title

Data Source

[Journal Article] A meta-analysis on the risk of developing malignancy associated with use of immunosunnressive agents in natients with inflammatory bowel disease2007

Author(s)

Journal Title

Data Source

ECHIZEN Hirotoshi 越前宏俊