Takahashi Shinichiro 高橋伸一郎

… Alternative Names

Researcher Number	00197146
Other IDs
Affiliation (Current)	2021: 東京大学, 大学院農学生命科学研究科(農学部), 教授
Affiliation (based on the past Project Information) *help	2017 – 2020: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2015 – 2017: 東京大学, 大学院農学生命科学研究科(農学部), 准教授 2014 – 2017: 東京大学, 大学院農学生命科学研究科, 准教授 2011 – 2016: 東京大学, 農学生命科学研究科, 准教授 2013: 東京大学, 大学院農学生命科学研究科(農学部), 准教授(移行) … More
Review Section/Research Field	Principal Investigator Applied animal science / Animal production science / Applied animal science / 応用生物化学・栄養化学 / 食品科学・栄養科学 / 応用微生物学・応用生物化学 / Medium-sized Section 42:Veterinary medical science, animal science, and related fields Except Principal Investigator Basic veterinary science/Basic zootechnical science / Applied animal science / Applied animal science … More
Keywords	Principal Investigator インスリン / インスリン様成長因子 / インスリン受容体基質 / 代謝・内分泌制御 / cAMP / 細胞内シグナル / インスリン様活性 / チロシンリン酸化 / 細胞増殖 / 糖取り込み … More Except Principal Investigator インスリン / インスリン受容体基質 / 糖取り込み / 脂肪細胞 / 脳・神経 / ステロイドホルモン / 成長因子 / 神経新生 / インスリン様成長因子 / チロシンリン酸化 / 糖尿病 / インスリン抵抗制 / サイトカイン / IRS-associated protein / DGKζ / PIP5k1α / GKAP42 / Insulin resistance / Adipocytes / Glucose uptake / GLUT4 translocation / プログラニュリン / 神経変性 / 性分化 / 組織幹細胞 / 機能性物質 / 哺乳類プライマーフェロモン / 雄効果フェロモン / GnRHパルスジェネレーター / 警報フェロモン / 安寧フェロモン / リガンド分子同定 / フェロモン受容体 / 中枢神経回路 / インスリン様成長因子結合タンパク質 / インスリン様成長因子レセプター / タンパク質栄養 / タンパク質代謝 / Insulin-like growth factors / Insulin-like growth factor binding proteins / Insulin-like growth factor-I receptor / Tyrosine phosphorylation / Protein nutrition / Protein metabolism / 肥満 / 成長ホルモン / トランスジェニックラット / 細胞内情報伝達 / インスリン受容体気質 / 成長ホルモン受容体 / Obesity / Diabetes / Insulin / Growth hormone / Transgenic rat / Signal transduction / Insulin receptor substrate / tyrosin phosphrylation / DNAメチル化 / エピジェネティクス / 脂肪細胞分化 / ES細胞 / ジメチルスルホキシド / DNAメチル基転移酵素 / エピジェネティックス / Dnmt / 肝臓 / パイロシークエンス法 / DNA methylation / Epigenetics / Adipogenesis / ES cell / Dimethyl Sulfoxide / DNA methyltransferase / Brain / Neuron / Steroid hormones / Growth factors / Neuroeenesis / 糖輸送担体 / ジアシルグリセロールキナーゼ / インスリン抵抗性 / 低分子化合物 / ジアルシグリセロールキナーゼ / ジアシルグリセロールキナーゼζ / 高糖尿病薬 / PIP5K / 糖輸送担体（GLUT4) / 細胞膜移行 / 2型糖尿病 / 脳卒中 / 脳卒中関連遺伝子 / 頭蓋内主幹動脈狭窄 / もやもや病 / 類もやもや病 / RNF213 / 脳卒中リスクアレル / 脳卒中遺伝子 / RNF213変異 / ゲノム解析 / 頭蓋内血管狭窄 / バイオマーカー / 成長障害 / GH-IGFシグナル / 遺伝子異常 / GH-IGF系経路関連蛋白 / 遺伝子解析 / 病態解明 / 次世代シークエンス / アミノ酸代謝 / 脂肪合成 / 脂肪肝 / 筋脂肪交雑 / 脂質代謝 / アミノ酸シグナル / 機械学習 / 人工知能 / 栄養学 / 応用動物 / 畜産学 / アミノ酸欠乏食 / 臓器特異的脂肪蓄積 / IGF / mTOR / 生理活性 / シグナル伝達 / アミノ酸栄養 Less

インスリン受容体基質のユビキチン修飾の制御機構とその生理的・病態的意義の解明Principal InvestigatorOngoing
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significancePrincipal Investigator
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Tissue specific lipid accumulation in response to amino acid signal
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
The elucidation of growth failure due to GH/IGF signaling abnormality
- Principal Investigator
  
  Kawashima Yuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
チアゾリジン化合物のＰＰＡＲγ非依存性経路を介した新規インスリン作用増強剤の開発Host Researcher
- Host Researcher
  
  高橋伸一郎, 高橋仲一郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complexPrincipal Investigator
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
動物の一生において時期・組織特異的にインスリン様活性を制御する新規機構とその意義Principal Investigator
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Identification and elucidation of the roles of RNAs associated with insulin receptor substratePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Basic research for ischemic stroke associated genes
- Principal Investigator
  
  Saito Nobuhito
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  The University of Tokyo
Analysis of insulin resistance through DGKz and development of anti-diabetic medicine
- Principal Investigator
  
  Hakuno Fumihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Isolation of drugs which rescue insulin resistance by activating GLUT4 transport activity.Principal Investigator
- Principal Investigator
  
  SHIN-ICHIRO Takahashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Novel mechanisms of growth regulation through changes in ubiquitination of insulin receptor substratesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Control of physiological function and behavior by mammalian pheromone
- Principal Investigator
  
  MORI Yuji
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Studies on Brain Actions of the Steroid/Growth Factor System
- Principal Investigator
  
  NISHIHARA Masugi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
mRNAスプライシング制御におけるインスリン受容体基質の新機能解明の試みPrincipal Investigator
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Interaction of steroid hormones and growth factors in maintaining brain function
- Principal Investigator
  
  NISHIHARA Masugi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Novel Molecular Mechanisms Underlying Modulation of Insulin-Like ActivitiesPrincipal Investigator
- Principal Investigator
  
  TAKAASHI Shin-ichiro
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
成長ホルモンにより発生するインスリン抵抗性の原因分子同定のための新しい試みPrincipal Investigator
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
DNA Methylation Analyses in Pathology
- Principal Investigator
  
  SHIOTANI Kunio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Cross-talk regulatory proteins that function for potentiation of IGF signals in stage-and tissue-specific mannersPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
New perspectives of the molecular mechanisms to potentiate IGF signalsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Applied animal science
- Research Institution
  THE UNIVERSITY OF TOKYO
Studies on mechanisms underlying the induction of insulin resistance using transgenic rats
- Principal Investigator
  
  NISHIHARA Masugi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  THE UNIVERSITY OF TOKYO
Mechanisms of Modulation of IGF's ActionPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-Ichiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The University of Tokyo
Chromosome mapping of genes in mammals and birds and its applcation for animal resource sciencesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-ichiro, ONODERA Kazukiyo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Modulation of IGF bioactivity by IGF-binding proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  The University of Tokyo
Protein Nutrition and IGF-I and IGF-related Proteins Nutritional Regulation of Biosynthesis and Biological Action of IGF-I and IGF-related Proteins.
- Principal Investigator
  
  NOGUCHI Tadashi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
The interaction between IGF-I-dependent and other hormones-dependent signal pathways in cell growth and differentiationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shin-ichiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  The University of Tokyo

[Book] Progress in Molecular Biology and Translational Science2016
- Author(s)
  Girnita L, Takahashi S-I, Crudden C, Fukushima T, Worrall C, Furuta H, Yoshihara H, Hakuno F, Girnita A.
- Total Pages
  34
- Publisher
  Elsevier Inc
- Data Source
  KAKENHI-PROJECT-25221204
[Book] 農学入門2013
- Author(s)
  高橋伸一郎
- Total Pages
  30
- Publisher
  養賢堂
- Data Source
  KAKENHI-PROJECT-25252047
[Book] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Total Pages
  11
- Publisher
  化学と生物
- Data Source
  KAKENHI-PROJECT-24380152
[Book] 農学入門2013
- Author(s)
  高橋伸一郎
- Total Pages
  30
- Publisher
  養賢堂
- Data Source
  KAKENHI-PROJECT-25660210
[Book] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Total Pages
  8
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-24380152
[Book] 「農学入門」第三部10章「農学と動物科学:巨大な細胞社会を統御する仕組みを知り利用する」(249-279)2013
- Author(s)
  高橋伸一郎
- Publisher
  養賢堂
- Data Source
  KAKENHI-PROJECT-22248030
[Book] 農学入門2013
- Author(s)
  高橋伸一郎
- Total Pages
  30
- Publisher
  養賢堂
- Data Source
  KAKENHI-PROJECT-22248030
[Book] 「農学入門」第三部10章「農学と動物科学：巨大な細胞社会を統御する仕組みを知り利用する」2013
- Author(s)
  高橋伸一郎
- Total Pages
  30
- Publisher
  養賢堂
- Data Source
  KAKENHI-PROJECT-25221204
[Book] 炎症・再生医学事典(掲載確定)2009
- Author(s)
  高橋伸一郎
- Total Pages
  4
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-20658065
[Book] 農芸化学に学ぶ:生活に生きるバイオサイエンス・バイオテクノロジー2006
- Author(s)
  高橋伸一郎
- Total Pages
  200
- Publisher
  エディプロ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Journal Article] Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation2020
- Author(s)
  Okino Ryosuke、Usui Ami、Yoneyama Yosuke、Takahashi Shin-Ichiro、Hakuno Fumihiko
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 11 Pages: 1-10
- DOI
  10.3389/fendo.2020.00096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16536, KAKENHI-PROJECT-18H03972
[Journal Article] Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes.2020
- Author(s)
  Hase Katsunori、Contu Viorica Raluca、Kabuta Chihana、Sakai Ryohei、Takahashi Masayuki、Kataoka Naoyuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Fujiwara Yuuki、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Autophagy
  
  Volume: - Pages: 1-15
- DOI
  10.1080/15548627.2020.1712109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-18F18384, KAKENHI-PROJECT-17K07124
[Journal Article] Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences2019
- Author(s)
  Masaki So、Ikeda Shun、Hata Asuka、Shiozawa Yusuke、Kon Ayana、Ogawa Seishi、Suzuki Kenji、Hakuno Fumihiko、Takahashi Shin-Ichiro、Kataoka Naoyuki
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 10 Pages: 338-338
- DOI
  10.3389/fgene.2019.00338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06012, KAKENHI-PROJECT-18K16084, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18H03972
[Journal Article] Prolyl isomerase Pin1 suppresses thermogenic programs in adipocytes by promoting degradation of transcriptional co-activator PRDM16.2019
- Author(s)
  Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
- Journal Title
  
  Cell reports
  
  Volume: 26 Pages: 3221-3230
- DOI
  10.1016/j.celrep.2019.02.066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K11670, KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16H06226, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-16K11503, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-19K17951, KAKENHI-PROJECT-17H01565, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-17K11644
[Journal Article] Low-protein diet enhances adiponectin secretion in rats2019
- Author(s)
  Yagi Takashi、Toyoshima Yuka、Tokita Reiko、Taguchi Yusuke、Okamoto Yoshihisa、Takahashi Shin-Ichiro、Kato Hisanori、Minami Shiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Pages: 1774-1781
- DOI
  10.1080/09168451.2019.1621153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05916, KAKENHI-PROJECT-18H03972
[Journal Article] IGF research 2016?20182019
- Author(s)
  Takahashi Shin-Ichiro
- Journal Title
  
  Growth Hormone & IGF Research
  
  Volume: 48-49 Pages: 65-69
- DOI
  10.1016/j.ghir.2019.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] インスリン様シグナルと代謝制御性アミノ酸シグナル：次世代栄養学『AI Nutrition』の提唱2019
- Author(s)
  高橋伸一郎、伯野史彦、山中大介、中林靖、豊島由香、竹中麻子
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 514-520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation2019
- Author(s)
  Ueda Koji、Nakatsu Yusuke、Yamamotoya Takeshi、Ono Hiraku、Inoue Yuki、Inoue Masa-Ki、Mizuno Yu、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Takahashi Shin-Ichiro、Matsubara Akio、Asano Tomoichiro
- Journal Title
  
  Oncotarget
  
  Volume: 10 Pages: 1637-1648
- DOI
  10.18632/oncotarget.26691
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-25221204
[Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line2018
- Author(s)
  Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
- Journal Title
  
  Oncotarget.
  
  Volume: 9(74) Pages: 33871-33883
- DOI
  10.18632/oncotarget.26049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-15J10937, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26221204
[Journal Article] 解説アミノ酸の新機能：血中プロファイルに応じた脂質代謝の変動2018
- Author(s)
  西宏起、伯野史彦、高橋伸一郎
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 76 Pages: 467-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling with clathrin adaptor AP2 complex.2018
- Author(s)
  Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.32893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
[Journal Article] 解説アミノ酸の新機能：血中プロファイルに応じた脂質代謝の変動2018
- Author(s)
  西宏起、伯野史彦、高橋伸一郎
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 76 Pages: 467-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] 成長ホルモンは，実は「異化ホルモン」である2018
- Author(s)
  高橋伸一郎、伯野史彦
- Journal Title
  
  成長代謝
  
  Volume: 9 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] 成長ホルモンは，実は「異化ホルモン」である2018
- Author(s)
  高橋伸一郎、伯野史彦
- Journal Title
  
  成長代謝
  
  Volume: 9 Pages: 1-4
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition.2018
- Author(s)
  Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Yasushi Nakabayashi, Ryuji Shioya, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Journal Title
  
  Sci. Rep.
  
  Volume: 8:5461 Pages: 1-11
- DOI
  10.1038/s41598-018-23640-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26390134, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-16J08326, KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-18K06014, KAKENHI-PROJECT-16K07747
[Journal Article] SM22α (Smooth Muscle Protein 22-α) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis2018
- Author(s)
  Sukhanov S, Higashi Y, Shai SY, Snarski P, Danchuk S, D'Ambra V, Tabony M, Woods TC, Hou X, Li Z, Ozoe A, Chandrasekar B, Takahashi S-I, Delafontaine P.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Pages: 2306-2317
- DOI
  10.1161/atvbaha.118.311134
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
[Journal Article] Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3?Ubiquitin Ligase2018
- Author(s)
  Yoneyama Y, Inamitsu T, Chida K, Iemura SI, NatsumeT, Maeda T, Hakuno F, Takahashi S-I
- Journal Title
  
  iScience
  
  Volume: 5 Pages: 1-18
- DOI
  10.1016/j.isci.2018.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17H03802, KAKENHI-PROJECT-25221204
[Journal Article] 40 YEARS OF IGF1: IGF1 receptor signaling pathways2018
- Author(s)
  Hakuno F, Takahashi SI.
- Journal Title
  
  Journal of Molecular Endocrinology
  
  Volume: -
- DOI
  10.1530/jme-17-0311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-25221204
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination2017
- Author(s)
  Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
- Journal Title
  
  Biochem. Biophys Res. Commun.
  
  Volume: 484 Pages: 522-528
- DOI
  10.1016/j.bbrc.2017.01.101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] Glucose deprivation attenuates sortilin levels in skeletal muscle cells2017
- Author(s)
  Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi S
- Journal Title
  
  Endocrine Journal
  
  Volume: 64 Issue: 3 Pages: 255-268
- DOI
  10.1507/endocrj.ej16-0319
  10.1507/endocrj.EJ16-0319
- NAID
  130005529466
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] The short-stature homeobox-containing gene (shox/SHOX) is required for the regulation of cell proliferation and bone differentiation in zebrafish embryo and human mesenchymal stem cells.2017
- Author(s)
  Yokokura T, Kamei H, Shibano T, Yamanaka D, Sawada-Yamaguchi R, Hakuno F, Takahashi SI, Shimizu T
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: -
- DOI
  10.3389/fendo.2017.00125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04583
[Journal Article] Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats.2017
- Author(s)
  Horiuchi Mami、Takeda Tomoya、Takanashi Hiroyuki、Ozaki-Masuzawa Yori、Taguchi Yusuke、Toyoshima Yuka、Otani Lila、Kato Hisanori、Sone-Yonezawa Meri、Hakuno Fumihiko、Takahashi Shin-Ichiro、Takenaka Asako
- Journal Title
  
  Nutrition and Metabolism
  
  Volume: 14 Pages: 1-12
- DOI
  10.1186/s12986-017-0215-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07747, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-16K18706
[Journal Article] Study of effects of blood amino acid and hormone level for controlling triglyceride accumulation in the liver of rats using self-organizing map.2016
- Author(s)
  Masato Masuda, Yasushi Nakabayashi, Ryuji Shioya, Hiroki Nishi, Shin-Ichiro Takahashi, Fumihiko Hakuno
- Journal Title
  
  International Journal of Intelligent Information System
  
  Volume: 5 Pages: 88-93
- DOI
  10.11648/j.ijiis.20160506.12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J08326, KAKENHI-PROJECT-26390134, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2016
- Author(s)
  高橋伸一郎、福嶋俊明、安藤康年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14840
[Journal Article] アミノ酸シグナルを利用した高品質食資源の開発技術の確立2016
- Author(s)
  高橋伸一郎、潮秀樹、加藤久典、伯野史彦、柴田重信、竹中麻子、豊島由香、勝俣昌也、中島一喜
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 4 Pages: 4-4
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues2016
- Author(s)
  Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S, Yamanouchi K, Nishihara M
- Journal Title
  
  Exp Cell Res.
  
  Volume: 347 Pages: 367-377
- DOI
  10.1016/j.yexcr.2016.08.023
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J08006, KAKENHI-PROJECT-25292185, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-16H05041
[Journal Article] Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016
- Author(s)
  L Girnita, S-I Takahashi, C Crudden, T Fukushima, C Worrall, H Furuta, H Yoshihara, F Hakuno, A Girnita
- Journal Title
  
  Progress in Molecular Biology and Translational Science
  
  Volume: 141 Pages: 277-311
- DOI
  10.1016/bs.pmbts.2016.04.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25221204
[Journal Article] Phosphatidylinositol 3-kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro and enhances endocytosis in HEK293 cells.2016
- Author(s)
  Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 7 Pages: 89-89
- DOI
  10.3389/fendo.2016.00089
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18812, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes2016
- Author(s)
  Liu TY, Yu BC, Kakino M, Fujimoto H, Ando Y, Hakuno F, Takahashi S-I
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 35438-35438
- DOI
  10.1038/srep35438
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2016
- Author(s)
  高橋伸一郎、福嶋俊明、安藤康年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis2015
- Author(s)
  Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
- Journal Title
  
  Mediators of Inflammation
  
  Volume: 2015 Pages: 10-10
- DOI
  10.1155/2015/125380
- NAID
  120005745641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25253019
[Journal Article] Analysis of insulin receptor substrate (IRS) signaling dynamics on micro-structured surfaces2015
- Author(s)
  Lanzerstorfer P, Yoneyama Y, Hakuno F, Muller U, Hoglinger O, Takahashi SI, Weghuber J
- Journal Title
  
  FEBS J
  
  Volume: 282 Pages: 987-1005
- DOI
  10.1111/febs.13213
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2015
- Author(s)
  高橋伸一郎、福嶋俊明、安藤泰年、伯野史彦
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 21-25
- NAID
  40020705836
- Data Source
  KAKENHI-PROJECT-15H04583
[Journal Article] Rapid increases of fibroblast growth factor 21 under protein malnutrition and its impact on growth and lipid metabolism2015
- Author(s)
  Yori Ozaki, Kenji Saito, Kyoko Nakazawa, Morichika Konishi, Nobuyuki Itoh, Fumihiko Hakuno, Shin-Ichiro Takahashi, Hisanori Kato and Asako Takenaka
- Journal Title
  
  Brit. J. Nutr.
  
  Volume: 114 Pages: 1410-1418
- DOI
  10.1017/s0007114515002846
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07444, KAKENHI-PROJECT-26460084, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins2015
- Author(s)
  Hakuno F, Fukushima T, Yoneyama Y, Kame H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu B-C, Chida K, Takahashi S-I
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: なし
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] In vivo of function study reveals the short stature homeobox-contaning gene plays indispensable role in early embryonic growth and bone formation in zebrafish2015
- Author(s)
  Sawada R., Kamei H., Hakuno F., Takahashi S., Shimizu T.
- Journal Title
  
  Developmental Dynamics
  
  Volume: 244 Pages: 146-156
- DOI
  10.1002/dvdy.24239
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-25221204
[Journal Article] The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins2015
- Author(s)
  Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 6 Pages: 73-73
- DOI
  10.3389/fendo.2015.00073
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-15K18799, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204
[Journal Article] TNF-aInduced Repression of GKAP42 Protein Levels through cGK-Ia Activity Causes Insulin Resistance in 3T3-L1 Adipocytes.2015
- Author(s)
  Ando Y, Shinozawa Y, Iijima Y, Yu B-C, Sone M, Ooi Y, Watanaka Y, Chida K, Hakuno F, Takahashi S-I
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Pages: 5881-5892
- DOI
  10.1074/jbc.m114.624759
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13F03089, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-25221204
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF-dependent signals and mitogenic activity2015
- Author(s)
  Fukushima, T., Yoshihara, H., Furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takabashi, S-I
- Journal Title
  
  Nature Commun.
  
  Volume: 6 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver2014
- Author(s)
  Yokota S-I, Nakamura K, Ando M, Kamei H, Hakuno F, Takahashi S-I, Shibata S. 2014 Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Pages: 905-914
- DOI
  10.1016/j.fob.2014.10.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats2014
- Author(s)
  Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Narumi Akiyama-Akanishi, Asako Takenaka, Hisanori Kato, Kazuhiro Chida, Fumihiko Hakuno, Shiro Minami, Shin-Ichiro Takahashi
- Journal Title
  
  Endocrine Journal
  
  Volume: 印刷中 Issue: 5 Pages: 499-512
- DOI
  10.1507/endocrj.ej13-0514
  10.1507/endocrj.EJ13-0514
- NAID
  130004443967
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25850095, KAKENHI-PROJECT-25221204
[Journal Article] Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats2014
- Author(s)
  Yori Ozaki, Tomoya Takeda, Narumi Akanishi, Fumihiko Hakuno, Yuka Toyoshima, Shin-Ichiro Takahashi & Asako Takenaka
- Journal Title
  
  Biosci. Biotech. Biochem.
  
  Volume: - Pages: 130-138
- DOI
  10.1080/09168451.2014.877825
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24580202, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25850095
[Journal Article] Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos2014
- Author(s)
  Liu C, Luan J, Bai Y, Li Y, Lu L, Liu Y, Hakuno F, Takahashi S, Duan C, Zhou J.
- Journal Title
  
  Gen Comp Endocrinol
  
  Volume: 197 Pages: 82-91
- DOI
  10.1016/j.ygcen.2013.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204
[Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis2014
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 5 Pages: 1-12
- DOI
  10.3389/fendo.2014.00024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25660210
[Journal Article] Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters2014
- Author(s)
  Kaneko M, Hakuno F, Kamei H, Yamanaka D, Chida K, Minami S, Coe RI, Takahashi S-I.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 443 Pages: 505-510
- DOI
  10.1016/j.bbrc.2013.11.132
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25850220
[Journal Article] Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growting rats.2014
- Author(s)
  Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S-I.
- Journal Title
  
  Endocrine J.
  
  Volume: 61 Pages: 499-512
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] PI 3-Kinase Activity Bound to IGF-I Receptor, Which is Continuously Sustained by IGF-I Stimulus, is Required for IGF-I-Induced Cell Proliferation.2013
- Author(s)
  Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 29713-21
- DOI
  10.1074/jbc.m112.393074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation.2013
- Author(s)
  Yosuke Yoneyama
- Journal Title
  
  Mol Cell Biol
  
  Volume: Volume 33 Pages: 1991-2003
- DOI
  10.1128/mcb.01394-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07756, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25252047
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Insulin injection restores increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but does not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.2013
- Author(s)
  Ozaki Y, Takeda T, Akiyama-Akanishi N, Hakuno F, Toyoshima Y, Takahashi S-I, Takenaka A.
- Journal Title
  
  Biosci. Biotech. Biochem.
  
  Volume: 79 Pages: 47-53
- DOI
  10.1007/s12562-012-0570-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152
[Journal Article] Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes.2013
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F, Takahashi S-I
- Journal Title
  
  FEBS Lett
  
  Volume: 587(15) Pages: 2319-2324
- DOI
  10.1016/j.febslet.2013.05.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25660210
[Journal Article] AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent cell proliferation2013
- Author(s)
  Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi SI,
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658222
[Journal Article] AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent cell proliferation2013
- Author(s)
  Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi SI,
- Journal Title
  
  Mol. Cell. Biol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380152
[Journal Article] Olfactory signals mediate social buffering of conditioned fear responses in male rats2013
- Author(s)
  Takahashi Y., Kiyokawa Y., Kodama Y., Arata S., Takeuchi Y., Mori Y.
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 240 Pages: 46-51
- DOI
  10.1016/j.bbr.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21228006, KAKENHI-PROJECT-23688035
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] Something old, something new and something borrowed; emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation2013
- Author(s)
  Girnita L, Worrall C, Takahashi S-I, Seregard S, Girnita A
- Journal Title
  
  Cell. Mol. Life Sci
  
  Volume: なし
- DOI
  10.1007/s00018-013-1514-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-25221204
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Data Source
  KAKENHI-PROJECT-25660210
[Journal Article] インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- NAID
  10031177626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25252047
[Journal Article] 解説:インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- URL
  http://www.jsbba.or.jp/pub/journal_kasei/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013
- Author(s)
  高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 934-941
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] 解説：インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 389-399
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221204
[Journal Article] Novel repressor regulates insulin sensitivity through interaction with Foxol2012
- Author(s)
  Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi SI, Itoh H
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 2275-2295
- DOI
  10.1038/emboj.2012.97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24650442, KAKENHI-PUBLICLY-24116507
[Journal Article] Phosphatidylinositol 3-Kinase Binding Protein, PI3KAP/XB130 is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells.2012
- Author(s)
  Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S-I.
- Journal Title
  
  Mol. Endocrinol.
  
  Volume: 26 Pages: 1043-1055
- DOI
  10.1210/me.2011-1349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24591375, KAKENHI-PROJECT-24790928
[Journal Article] Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.Biochem Biophys Res Commun.2012
- Author(s)
  Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S-I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 423 Pages: 122-127
- DOI
  10.1016/j.bbrc.2012.05.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22687009, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxol in L6 myoblasts2011
- Author(s)
  Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S
- Journal Title
  
  PLoS One
  
  Volume: 6
- DOI
  10.1371/journal.pone.0025655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248027, KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780190, KAKENHI-PROJECT-23658174
[Journal Article] HSP90 interactingwith IRS-2 is involved in cAMP-dependentpotentiation of IGF-I signals in FRTL-5cells.2011
- Author(s)
  Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
- Journal Title
  
  Molecular and Cellular Endocrinolology
  
  Volume: 344 Pages: 81-89
- DOI
  10.1016/j.mce.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011
- Author(s)
  Fukushima T, Takahashi S-I, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 404 Pages: 767-773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Insulin receptorsubstrates form high-molecular-masscomplexes that modulate theiravailability to insulin/ insulin-likegrowth factor-I receptor tyrosine kinases.2011
- Author(s)
  Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I
- Journal Title
  
  Biochemical and Biophysical Research Communications,
  
  Volume: 404 Pages: 767-73
- DOI
  10.1016/j.bbrc.2010.12.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] 発達と成長を司るホルモン、インスリン様成長因子2010
- Author(s)
  高橋伸一郎, ら
- Journal Title
  
  日本未熟児新生児学会雑誌
  
  Volume: 22 Pages: 19-25
- NAID
  10026440072
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-κB activity2010
- Author(s)
  Kabuta T, Takahashi S-I, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 394 Pages: 697-702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Dietary protein deprivation up-regulates insulin signaling and inhibits gluconeogenesis in rat liver2010
- Author(s)
  Toyoshima Y, Takahashi S-I, et al
- Journal Title
  
  J Mol Endocrinol
  
  Volume: 45 Pages: 329-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] Paraquat-induced oxidative stress represses PI 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes2010
- Author(s)
  Shibata M, Takahashi S-I, et al
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 20916-20925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030
[Journal Article] 発達と成長を司るホルモン、インスリン様成長因子2010
- Author(s)
  高橋伸一郎, ら
- Journal Title
  
  日本未熟児新生児学会誌 22
  
  Pages: 19-25
- NAID
  10026440072
- Data Source
  KAKENHI-PROJECT-20658065
[Journal Article] 成長ホルモン、インスリン様成長因子、インスリンの代謝活性の連携2009
- Author(s)
  高橋伸一郎, ら
- Journal Title
  
  ホルモンと臨床 57
  
  Pages: 307-317
- Data Source
  KAKENHI-PROJECT-20658065
[Journal Article] 成長ホルモン、インスリン様成長因子、インスリンの代謝活性の連携2009
- Author(s)
  高橋伸一郎
- Journal Title
  
  ホルモンと臨床 (掲載確定)
- Data Source
  KAKENHI-PROJECT-20658065
[Journal Article] 成長ホルモンとインスリンのクロストーク2004
- Author(s)
  高橋伸一郎
- Journal Title
  
  エクセプタ・メディカ「成長発達」 10
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-15658080
[Patent] 新しいメカニズムでインスリン様活性を発現するDiacylglycerol kinase(DGK)ζのスプライシングバリアントshort-form DGKζ(sDGKζ)2005
- Inventor(s)
  高橋伸一郎
- Industrial Property Rights Holder
  高橋伸一郎
- Industrial Property Number
  2005-075627
- Filing Date
  2005-03-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] Synchronization of IGF signal by cell competition during myogenesis2019
- Author(s)
  Fumihiko Hakuno, Masato Masuda, Ryosuke Okino, Shin-Ichiro Takahashi
- Organizer
  第57回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 血中アミノ酸プロファイルが肝臓への脂肪蓄積量を決定する2019
- Author(s)
  増田正人、西宏起、山中大介、高橋伸一郎、伯野史彦
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 肝細胞においてオルニチンを介した新規アミノ酸シグナル経路がmTOR非依存的にG6Pase遺伝子発現を制御する2019
- Author(s)
  福嶋沙良、熊野未佳子、西宏起、山中大介、合田祐貴、豊島由香、竹中麻子、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 代謝制御性アミノ酸シグナルとインスリン様シグナル：次世代栄養学『AI Nutrition』のすすめ2019
- Author(s)
  高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Function of pyrroline-5-carboxylate reductase 2 (PYCR2) which associates with insulin receptor substrate (IRS) 2 in cell survival in neuroblastoma cells. Poster presentation.2019
- Author(s)
  Eisuke Kaba, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 代謝制御性アミノ酸シグナルとインスリン様シグナル：次世代栄養学『AI Nutrition』のすすめ2019
- Author(s)
  高橋伸一郎
- Organizer
  EDGE-J Japan 2019
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] アミノ酸欠乏がミトコンドリアの伸長を誘導する分子メカニズム2019
- Author(s)
  小林萌泉、宮本崇史、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Amino acid signals regulate metabolism: Effectiveness of AI Nutrition for the Next-Generation Study of Nutrition2019
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Fisheries Science Research Institute Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 分化過程でのIRS-1の発現量の違いによって生じる細胞競合の意義2019
- Author(s)
  沖野良輔、臼井杏美、増田正人、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] The mechanism of cell competition induced by differential IRS-1 expression in myoblasts.2019
- Author(s)
  Ryosuke OKINO, Ami USUI, Fumihiko HAKUNO, Shin-Ichiro TAKAHASHI
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Function of pyrroline-5-carboxylate reductase 2 (PYCR2) which associates with insulin receptor substrate (IRS) 2 in cell survival in neuroblastoma cells.2019
- Author(s)
  Eisuke Kaba, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation.2019
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 前立腺がん細胞においてIRS-2の高発現によりMMP-9の産生が亢進しIGF-I依存的な細胞増殖が誘導される2019
- Author(s)
  古田遥佳、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 数理学シミュレーションを用いた生体内でのインスリン様成長因子（IGF）シグナル伝達解析の試み2019
- Author(s)
  伯野史彦、増田正人、渡邉聡、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Numerical simulation of insulin-like growth factor-I (IGF-I) signal2019
- Author(s)
  Fumihiko Hakuno, Masato Masuda, Tatsuya Hayashi, Shin-Ichiro Takahashi
- Organizer
  第57回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Co-creating the future society through the “One Earth Guardians Development Program”2019
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  戦略的パートナーシップ台湾大学第４回Joint Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルによる物質代謝の調節ーアミノ酸バランスを意識した蛋白質の摂取と健康寿命ー2019
- Author(s)
  高橋伸一郎
- Organizer
  第29回臨床内分泌代謝Update
- Invited
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 進化から学ぶ動物の一生に果たすインスリン様ペプチドの役割2019
- Author(s)
  高橋伸一郎
- Organizer
  日本抗加齢医学会専門医・指導士認定委員会講習会
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes.2019
- Author(s)
  Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] 進化から学ぶ動物の一生に果たすインスリン様ペプチドの役割2019
- Author(s)
  高橋伸一郎
- Organizer
  日本抗加齢医学会専門医・指導士認定委員会講習会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes2019
- Author(s)
  Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The mechanism of cell competition induced by differential IRS-1 expression in myoblasts.2019
- Author(s)
  Ryosuke OKINO, Ami USUI, Fumihiko HAKUNO, Shin-Ichiro TAKAHASHI
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] タンパク質食給餌によって起こるマウスの成長遅滞はInsulin-like Growth Factor-1（IGF-I）投与により回復する2019
- Author(s)
  内田海登、豊島由香、伯野史彦、高橋伸一郎、竹中麻子
- Organizer
  日本アミノ酸学会第13回学術大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019
- Author(s)
  Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation.2019
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019
- Author(s)
  Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Somatomedins and I.2018
- Author(s)
  Shin-Ichrio Takahashi
- Organizer
  Amgen Scholars Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Distinct pathways of GH and TNF-a for suppression of insulin-dependent glucose uptake2018
- Author(s)
  Lisa Nakata, Meri Yonezawa-Sone, Tomomi Ogata, Kouhei Kasahara, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Two Years in IGF Research 2016-20182018
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Distinct pathways of GH and TNF-a for suppression of insulin-dependent glucose uptake2018
- Author(s)
  Lisa Nakata, Meri Yonezawa-Sone, Tomomi Ogata, Kouhei Kasahara, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Effects of Amino Acids on Hepatic Gene Expression of Insulin-like Growth Factor-I2018
- Author(s)
  Haruka Nagata, Daisuke Yamanaka, Hiroki Nishi, Yuuki Gouda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The difference of IRS-1 protein expression level caused cell competition2018
- Author(s)
  Fumihiko Hakuno, Ami Usui, Hiroyasu Kamei, Ryosuke Okino, Yosuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルとインスリン様シグナルによる物質代謝の調節2018
- Author(s)
  高橋伸一郎
- Organizer
  第39回日本基礎老化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effects of Amino Acids on Hepatic Gene Expression of Insulin-like Growth Factor-I2018
- Author(s)
  Haruka Nagata, Daisuke Yamanaka, Hiroki Nishi, Yuuki Gouda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] アミノ酸シグナルとインスリン様シグナルによる物質代謝の調節2018
- Author(s)
  高橋伸一郎
- Organizer
  第39回日本基礎老化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] The difference of IRS-1 protein expression level caused cell competition2018
- Author(s)
  Fumihiko Hakuno, Ami Usui, Hiroyasu Kamei, Ryosuke Okino, Yosuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Two Years in IGF Research 2016-20182018
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  The 9th GRS-IGF International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018
- Author(s)
  山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
- Organizer
  第12回アミノ酸学会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Insulin receptor substrate (IRS)1を過剰発現した筋芽細胞で観察される細胞競合の発生メカニズム2018
- Author(s)
  沖野良輔、臼井杏美、伯野史彦、高橋伸一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 進化から学ぶインスリン様成長因子／インスリンシステムの生理的意義2018
- Author(s)
  高橋伸一郎
- Organizer
  日本農芸化学会2018年大会シンポジウム「食の代謝・進化から迫る生命の戦略」
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Insulin receptor substrate (IRS)1を過剰発現した筋芽細胞で観察される細胞競合の発生メカニズム2018
- Author(s)
  沖野良輔、臼井杏美、伯野史彦、高橋伸一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Somatomedins and I.2018
- Author(s)
  Shin-Ichrio Takahashi
- Organizer
  Amgen Scholars Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Roles of Insulin/Insulin-like growth factor signaling in hypoxia/reoxygenation induced catch-up growth in zebrafish embryo2017
- Author(s)
  Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Dietary amino acids control lipid accumulation in the liver, skeletal muscle or adipose tissue in an amino acid-specific manner2017
- Author(s)
  Daisuke Yamanaka, Hiroki Nishi, Yuki Goda, 1Mikako Kumano, Koichi Ito, Masaya Katsumata, Hisanori Kato, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] mTOR によるIRS-1 の分解制御がインスリン様成長因子シグナルの時間的制御に果たす役割2017
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats2017
- Author(s)
  Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Masugi Nishihara, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 自己組織化マップを用いた食餌中アミノ酸濃度、血中アミノ酸濃度、肝臓脂肪量の関係分類2017
- Author(s)
  伯野史彦、増田正人、中林靖、西宏起、山中大介、高橋伸一郎、塩谷隆二
- Organizer
  計算力学学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Amino acid-deficiency signal induces insulin-like effects on regulation of gluconeogenic gene regulation independently of insulin signaling in hepatocytes2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Serine phosphorylation of GLUT4 positively controls glucose transport activity of GLUT4 causing insulin resistance by growth hormone2017
- Author(s)
  Fumihiko Hakuno, Chihiro Watanabe, Lisa Nakata,Mamiko Kubo, Meri-Yonezawa-Sone, Kohei, Kasahara, Shin‐Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Rapid increase in fibroblast growth factor 21 under protein malnutrition and its impact on growth, insulin secretion and lipid metabolism2017
- Author(s)
  Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Discovery of novel anti-diabetic drugs by interrupting the association between DGKζ and IRS-12017
- Author(s)
  Bu-Chin Yu, Akihiro Ito, Minoru Yoshida, Yasutoshi Ando, Tin-Yu Liu, Fumihiko Hukuno, Kazuhiro Chida , Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017
- Author(s)
  Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Amino acid-deficiency signal induces insulin-like effects on gluconeogenic gene regulation independently of insulin signaling in hepatocytes.2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Serine phosphorylation of GLUT4 positively controls glucose transport activity of GLUT4 causing insulin resistance by growth hormone.2017
- Author(s)
  Hakuno, Fumihiko, Chihiro Watanabe, Lisa Nakata, Mamiko Kubo, Meri Yonezawa- Sone, Kohei Kasahara, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体RNAの組織特異的な選択的スプライシング機構の解析2017
- Author(s)
  Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, 名倉敬仁、尾添敦文、成田佑果、太田一実、千田和広、伯野史彦、片岡直行、高橋伸一郎
- Organizer
  19回日本RNA学会年会　RNA2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition2017
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Ryuji Shioya, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The SCFβ-TRCP E3 ligase complex induces IRS-1 degradation mediated by mTORC1 pathway2017
- Author(s)
  Tomomi Inamitsu, Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの組織特異的な選択的スプライシング機構の解析2017
- Author(s)
  名倉敬仁、尾添敦文、成田佑果、西宏起、千田和広、伯野史彦、片岡直行、高橋伸一郎
- Organizer
  第40回日本分子生物学会年会 2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Insulin receptor substrates-associated proteins that are involved in the insulin resistance2017
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Short stature with IGF-I receptor gene anomaly.2017
- Author(s)
  Yuki Kawashima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Prolonged IGF signaling by IRS-1-mediated control of delayed IGF-IR internalization2017
- Author(s)
  Yosuke Yoneyama, Fumihiko, Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF/insulin signaling through a novel mechanism2017
- Author(s)
  Toshiaki Fukushima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats.2017
- Author(s)
  Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Takahashi SI
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Regulation of Insulin-like activities through alternative splicing of Insulin Receptor pre-mRNA2017
- Author(s)
  Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルによる物質代謝の調節機構2017
- Author(s)
  高橋伸一郎
- Organizer
  第44回日本神経内分泌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Insulin receptor substrate 2 (IRS2) に相互作用するタンパク質、Pyrroline-5-carboxylate reductase 2 (PYCR2) が細胞死に及ぼす影響の解析2017
- Author(s)
  蒲瑛介、曽根（米澤）芽里、伯野史彦、高橋伸一郎
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Temporal regulation of insulin-like growth factor signaling by IRS-1-dependent feedback loops2017
- Author(s)
  ousuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Regulation of insulin-like activities through alternative splicing of insulin receptor pre-mRNA.2017
- Author(s)
  Naoyuki Kataoka, Shin-Ichiro Takahashi
- Organizer
  International Seminar on insulin-like signaling and nutrient signaling
- Place of Presentation
  東京大学農学部中島ホール（東京都、文京区）
- Year and Date
  2017-01-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] 古くて新しいアミノ酸シグナルによるインスリン様活性の調節機構2017
- Author(s)
  高橋伸一郎、伯野史彦、潮秀樹、加藤久典、竹中麻子、豊島由香、増田正人
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] アミノ酸欠乏に応答した肝臓の糖新生酵素遺伝子の発現抑制機構の解明2017
- Author(s)
  Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Introduction: Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals2017
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 古くて新しいアミノ酸シグナルによるインスリン様活性の調節機構2017
- Author(s)
  高橋伸一郎、伯野史彦、潮秀樹、加藤久典、竹中麻子、豊島由香、増田正人
- Organizer
  第40回日本分子生物学会年会 2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition.2017
- Author(s)
  ○Nishi, Hiroki, Daisuke Yamanaka1, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Ryuji Shioya, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 3T3-L1脂肪細胞のインスリン依存的な糖取り込みに果たすAkt基質、AS47とAS105の機能2017
- Author(s)
  中田理沙、曽根（米澤）芽里、緒形友美、笠原浩平、高橋伸一郎、伯野史彦
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition.2017
- Author(s)
  Hiroki Nishi. Daisuke Yamanaka. Hiroyasu Kamei. Yuki Goda. Mikako Kumano. Yuka Toyoshima. Asako Takenaka. Kazuhiro Chida. Fumihiko Hakuno. Shin-Ichiro Takahashi
- Organizer
  国際栄養学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] アミノ酸欠乏が肝臓のインスリン成長因子-I遺伝子発現に及ぼす影響の解析2017
- Author(s)
  長田悠加、山中大介、西宏起、合田祐貴、熊野未佳子、豊島由香、竹中麻子、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Early embryonic insulin receptor substrate-1 signaling underpins neural crest cell survival contributing to catch-up growth induced by changing environmental oxygen tension in developing zebrafish.2017
- Author(s)
  Hiroyasu Kamei, Yosuke Yoneyama, Fumihiko Hakuno, Rie Sawada, Toshiaki Shimizu, Cunming Duan, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017
- Author(s)
  Ami Usui, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin system in Physiology & Disease
- Place of Presentation
  Marriot Hotel Ventura (Ventura, CA, USA)
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats.2017
- Author(s)
  Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Masugi Nishihara, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  国際栄養学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Molecular functions and physiological significance of a novel PI 3-kinase-binding protein that potentiates IGF activities2017
- Author(s)
  Daisuke Yamanaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017
- Author(s)
  Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGFシグナル異常による成長制御2017
- Author(s)
  伯野史彦、鞁嶋有紀、神崎晋、高橋伸一郎
- Organizer
  内分泌代謝サマーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 栄養と代謝を繋ぐホルモン：アミノ酸シグナルとインスリン様シグナル2016
- Author(s)
  高橋伸一郎
- Organizer
  赤ちゃん歯科ネットワーク講演会
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Place of Presentation
  国立京都国際会館（京都府、京都）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] OR複合体1経路がインスリン受容体基質の分解とインスリン様成長因子（IGF）I受容体のエンドサイトーシスに果たす役割2016
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 全アミノ酸あるいはリジンを不足させた食餌を給餌した成長期のラットでは脂肪組織が増加する2016
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、勝俣昌也、加藤久典、豊島由香、竹中麻子、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel Roles of the Akt Substrate, AS47 in GH-Induced Inhibition of Insulin-Stimulated Glucose Uptake in Adipocytes without Affecting GLUT4 Translocation to Plasma Membranes2016
- Author(s)
  Meri Yonezawa-Sone, Kouhei Kasahara, Lisa Nakata, Chihiro Watanabe, Keitaro Yamanouchi, Masugi Nishihara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  8th International Congress of GRS-IGF society,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] RNAを含むインスリン受容体基質複合体の新機2016
- Author(s)
  高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルとインスリン様シグナル: 低タンパク質栄養状態に応答した代謝調節の分子機構と高品質畜産物開発技術への利用2016
- Author(s)
  高橋伸一郎
- Organizer
  動物・飼料に関する月例研究会
- Place of Presentation
  馬事畜産会館（東京都、中央区）
- Year and Date
  2016-01-22
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] TOR複合体1経路がインスリン受容体基質の分解とインスリン様成長因子（IGF）I受容体のエンドサイトーシスに果たす役割2016
- Author(s)
  米山鷹介、稲光智美、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Place of Presentation
  東京大学　（東京、文京区）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] アミノ酸シグナルに応答した肝臓への脂質蓄積機構の解明2016
- Author(s)
  西宏起、亀井宏泰、山中大介、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルに応答した肝臓への脂質蓄積機構の解明2016
- Author(s)
  西宏起、亀井宏泰、山中大介、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第6回TOR研究会
- Place of Presentation
  東京大学　（東京、文京区）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体基質に相互作用するタンパク質2016
- Author(s)
  高橋伸一郎
- Organizer
  東北大学医学部セミナー
- Place of Presentation
  東北大学医学部（宮城県、仙台市）
- Year and Date
  2016-03-04
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The Novel Role of Glucose Transporter 4 Serine Phosphorylation in Insulin Resistance Induced by Growth Hormone2016
- Author(s)
  Chihiro Watanabe, Mamiko Kubo, Meri Yonezawa-Sone, Kohei Kasahara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体基質がcap非依存的翻訳促進に果たす新規機能2016
- Author(s)
  中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] SCFユビキチンリガーゼ複合体によるリン酸化依存的なインスリン受容体基質の分解制御2016
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川、横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Actin cytoskeleton remodeling dynmics of adherent cells under to the photo-induced mechanical strain of gelatin substrate2016
- Author(s)
  Kwokhoi Ng, Kentaro Iketaki, Ryuzo Kawamura, Seiichiro Nakabayashi, Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi, Fumiki Yanagawa, Toshiyuki Takagi, Shinji Sugiura, Toshiyuki Kawamori, Hiroshi Yoshikawa
- Organizer
  日本生物物理学会
- Place of Presentation
  つくば国際会議場（茨城、つくば）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] インスリン受容体基質がcap非依存的翻訳促進に果たす新規機能2016
- Author(s)
  中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター、札幌市産業振興センター、札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] 栄養情報と成長を繋ぐホルモン、インスリン様ペプチド2016
- Author(s)
  高橋伸一郎
- Organizer
  第30回東北成長障害・成長因子研究会
- Place of Presentation
  仙台国際ホテル（宮城県、仙台市）
- Year and Date
  2016-03-05
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] RNAを含むインスリン受容体基質複合体の新機能2016
- Author(s)
  高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] SCFユビキチンリガーゼ複合体によるリン酸化依存的なインスリン受容体基質の分解制御2016
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrates (IRSs), interacting with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulate cap-independent translation2016
- Author(s)
  Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
- Organizer
  RNA2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Actin cytoskeleton remodeling dynmics of adherent cells under to the photo-induced mechanical strain of gelatin substrate2016
- Author(s)
  Kwokhoi Ng, Kentaro Iketaki, Ryuzo Kawamura, Seiichiro Nakabayashi, Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi, Fumiki Yanagawa, Toshiyuki Takagi, Shinji Sugiura, Toshiyuki Kanamori, Hiroshi Yoshikawa
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2016
- Author(s)
  Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
- Organizer
  RNA2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルによるインスリン様活性の調節：栄養に応答した物質代謝調節のダイナミクス2016
- Author(s)
  高橋伸一郎
- Organizer
  平成28年度日本農芸化学会東北支部シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Development of a new method for evaluating cell mechano-response to multidirectional and anisotropic mechanical strain by using photodegradable hydrogel2016
- Author(s)
  KAWAMURA Ryuzo; KWOKHOI, Ng; TANAKA Taisei; KOJIMAMasaru; ARAI Tatsuo; YONEYAMA, Yosuke; HAKUNO, Fumihiko; TAKAHASHI, Shin-ichiro; TAKAGI, Toshiyuki; KANAMORI, Toshiyuki; NAKABAYASHI Seiichiro; SUGIURA Shinji
- Organizer
  コロイドおよび界面化学討論会
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 全アミノ酸あるいはリジンを不足させた食餌を給餌した成長期のラットでは脂肪組織が増加する2016
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、勝俣昌也、加藤久典、豊島由香、竹中麻子、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川、横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] ソマトメジンと私2016
- Author(s)
  高橋伸一郎
- Organizer
  第41回東京成長ホルモン成長因子セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] AMPシグナルとインスリン様シグナルのクロストークから明らかとなったインスリン様活性の新しい調節機構2016
- Author(s)
  高橋伸一郎
- Organizer
  第13回GPCR研究会
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルを利用した臓器特異的な脂肪蓄積技術の確立とその利用2016
- Author(s)
  高橋伸一郎、潮秀樹、加藤久典、柴田重信、竹中麻子、鈴木由香、勝俣昌也、中島一喜、塩谷隆二
- Organizer
  知の集積と活用の場産学官連携協議会ポスターセッション
- Place of Presentation
  東京海洋大学越中島キャンパス八十五周年記念会館（東京都、江東区）
- Year and Date
  2016-03-07
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン様活性から見たクワシオルコル2015
- Author(s)
  高橋伸一郎
- Organizer
  第15回新生児栄養フォーラム
- Place of Presentation
  飯田橋、東京
- Year and Date
  2015-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Effect of branched-chain amino acids on insulin secretion during feeding.2015
- Author(s)
  Mami Horiuchi, Tomoya Takeda, Yori Ozaki, Fumihiko Hakuno, Shin-Ichiro Takahashi, Asako Takenaka.
- Organizer
  12th Asian Congress of Nutrition.
- Place of Presentation
  Yokohama Japan
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  ワークショップ・BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会
- Place of Presentation
  神戸国際会議場、神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] クラスリンアダプタータンパク質AP-2との相互作用を介したIRS-1によるIGF-I受容体エンドサイトーシスの新規フィードバック制御機構2015
- Author(s)
  米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrates (IRSs) form high-molecular-mass complexes with various proteins that control RNA splicing and translation2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  5th Nagasaki University-Pusan University Joint Seminar of Aging Research
- Place of Presentation
  長崎
- Year and Date
  2015-02-06
- Invited
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] GLUT4のセリンリン酸化が糖膜透過能に果たす役割2015
- Author(s)
  渡部千尋, 久保真実子, 米澤（曽根）芽里, 伯野史彦, 高橋伸一郎
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin Receptor Substrate-Associated Proteins: The keys to regulate insulin-like actions2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Invited lecture hosted by Dr. Rosemary O’Connor at University College Cork
- Place of Presentation
  University College Cork (Cork, Ireland)
- Year and Date
  2015-09-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS1を恒常的に発現したL6筋芽細胞は細胞競合を引き起こし、筋分化が抑制される2015
- Author(s)
  伯野史彦、米山鷹介、臼井杏美、高橋伸一郎
- Organizer
  第４回細胞競合コロキウム
- Place of Presentation
  北海道大学　遺伝子病制御研究所、北海道
- Year and Date
  2015-03-12
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS-1 is a negative feedback regulator of IGF-I receptor internalization via interaction with AP-2 clathrin adaptor complex2015
- Author(s)
  Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン様活性から見たクワシオルコル2015
- Author(s)
  高橋伸一郎
- Organizer
  第15回新生児栄養フォーラム
- Place of Presentation
  飯田橋レインボービル（東京都、新宿区）
- Year and Date
  2015-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] PI 3-kinase-binding protein PI3KAP plays an important role in cell migration and is required for embryogenesis in zebrafish2015
- Author(s)
  Hiroki Kawauchi, Daisuke Yamanaka, Hiroyasu Kamei, Fumihiko Hakuno, Shiro Minami, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  ワークショップ第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Insulin receptor substrates- associated proteins which are related with insulin resistance2015
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Spain, Madrid
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells2015
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Metabolic diseases, metabolic syndrome, metabolomics, and aging2015
- Author(s)
  BuChin Yu, TingYu Liu, Yasutoshi Ando, Akihiro Ito, Minoru Yoshida, Fumihiko Hakuno, Kazuhiro Chida and Shin-Ichiro Takahashi
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGF-I研究の最前線2015
- Author(s)
  高橋伸一郎
- Organizer
  GH/IGF-I & longevity
- Place of Presentation
  虎ノ門ヒルズフォーラム（東京都、港区）
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 食餌中の全アミノ酸やリジンの不足は筋肉への脂肪蓄積を誘導する2015
- Author(s)
  合田祐貴、西宏起、山中大介、亀井宏泰、山内啓太郎、勝俣昌也、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Protein malnutrition increases the amount and phosphorylation of 4E-binding protein 1 (4E-BP1) to accumulate lipid in rat liver2015
- Author(s)
  Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Fumiaki Yoshizawa, Shin-Ichiro Takahashi, Hisanori Kato, and Shiro Minami
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin Receptor Substrate-Associated Proteins: The keys to regulate insulin-like actions2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  invited lecture hosted by Dr. Rosemary O’Connor at University College Cork
- Place of Presentation
  University College Cork, Ireland
- Year and Date
  2015-09-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Fatty liver caused by acute amino acid deficiency2015
- Author(s)
  Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Keynote Lecture: Insulin receptor substrates (IRSs) form high-molecular-mass complexes with various proteins that control RNA splicing and translation2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  5th Nagasaki University-Pusan University Joint Seminar of Aging Research
- Place of Presentation
  長崎大学、長崎
- Year and Date
  2015-02-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルを利用した白肝の生産技術の開発-なぜ、動物のタンパク質栄養状態の悪化は成長遅滞と肝脂肪蓄積を引き起こすか2015
- Author(s)
  高橋伸一郎
- Organizer
  第55回澱粉研究懇談会
- Place of Presentation
  ホテルラヴィエ川良（神奈川県、伊東市）
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS-1の細胞膜への恒常的発現が骨格筋分化に及ぼす影響の解析2015
- Author(s)
  臼井杏美、伯野史彦、米山鷹介、高橋伸一郎
- Organizer
  第４回細胞競合コロキウム
- Place of Presentation
  北海道大学　遺伝子病制御研究所、北海道
- Year and Date
  2015-03-12
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrates- associated proteins which are related with insulin resistance2015
- Author(s)
  Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 筋分化過程でIRS-1の発現量の違いが細胞競合を引き起こす2015
- Author(s)
  臼井杏美、米山鷹介、千田和広、高橋伸一郎、伯野史彦
- Organizer
  BMB2015（第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin-induced acetyl-CoA carboxylase alpha is responsible for triglyceride accumulation in primary hepatocytes of low protein diet-fed rats.2015
- Author(s)
  Yusuke Taguchi, Yuka Toyoshima, Reiko Tokita, Hisanori Kato, Shin-Ichiro Takahashi, Shiro Minami.
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Fatty liver caused by acute amino acid deficiency2015
- Author(s)
  Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Diacylglycerol kinase zeta and PIP5K1 cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes2015
- Author(s)
  Fumihiko Hakuno, Ting-Yu Liu T, M Kakino, Hitoshi Fujimoto, Yasutoshi Ando, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Institute Lecture: Insulin receptor substrates (IRSs) form high-molecular-mass complexes with various proteins that control RNA splicing and translation2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Cajal Institute Seminar
- Place of Presentation
  Madrid, Spain
- Year and Date
  2015-02-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 肝臓におけるアミノ酸欠乏に応答したインスリン受容体基質（IRS）-2量の増加とトリグリセリドの蓄積の新規分子機構2015
- Author(s)
  西宏起、亀井宏泰、山中大介、赤西成美、森友美、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会2015年大会
- Place of Presentation
  岡山大学津島キャンパス、岡山
- Year and Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Lipid accumulation in muscle by chronic amino acid deficiency2015
- Author(s)
  Yuuki Gouda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  スペイン　マドリッド
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Regulation of alternative splicing of insulin receptor RNA by insulin receptor substrate2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Early embryonic Irs-1 signaling governs the neural crest cell survival that is indispensable for catch-up growth in zebrafish embryo induced by the changing environmental oxygen tension2015
- Author(s)
  Hiroyasu Kamei H, Yosuke Yoneyama, Rie Sawada R, Cunming Duan, Fumihiko Hakuno, Toshiaki Shimizu T, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸欠乏をシグナルとした肝臓特異的な脂質蓄積の新機構の解明2015
- Author(s)
  西宏起、山中大介、亀井宏泰、森友美、豊島由香、竹中麻子、潮秀樹、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Spain, Madrid
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Regulation of alternative splicing of insulin receptor RNA by insulin receptor substrate2015
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute, Madrid, Spain
- Year and Date
  2015-09-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] 筋分化過程でIRS-1の発現量の違いが細胞競合を引き起こす2015
- Author(s)
  臼井杏美、米山鷹介、千田和広、高橋伸一郎、伯野史彦
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04583
[Presentation] セリン／スレオニンホスファターゼPP1/PP2Aがインスリン受容体基質のリン酸化と分解の調節に果たす役割2015
- Author(s)
  稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
- Organizer
  BMB2015 （第38回日本分子生物学会年会／第88回日本生化学大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015
- Author(s)
  Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
- Organizer
  International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
- Place of Presentation
  Cajal Institute (Madrid, Spain）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The protein or compound that inhibits interaction between DGKζ and IRS-1 restore the TNF-α-induced suppression of glucose uptake in 3T3-L1 adipocytes.2015
- Author(s)
  Yu BC, Liu TY, Ando Y, Ito A, Yoshida M, Hakuno F , Chida K, Takahashi S-I
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] GH/IGF-I & longevity 教育講演：IGF-I研究の最前線2015
- Author(s)
  高橋伸一郎
- Organizer
  Pfizer Endocrinology Forum 2015 / GH/IGF-I & Longevity
- Place of Presentation
  虎ノ門ヒルズフォーラム
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K14840
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2015
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Effect of branched-chain amino acids on insulin secretion during feeding2015
- Author(s)
  Mami Horiuchi, Tomoya Takeda, Yori Ozaki, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] GLUT4のセリンリン酸化が糖膜透過能に果たす役割2015
- Author(s)
  渡部千尋、久保真実子、米澤（曽根）芽里、伯野史彦、高橋伸一郎
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015
- Author(s)
  高橋伸一郎、伯野史彦、安藤康年
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Impaired mTORC1 activity up-regulates IGFBP-1 synthesis during dietary protein restriction2014
- Author(s)
  Mika Hino, Kanae Takeuchi, Shin-Ichiro Takahashi, Asako Takenaka
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 脂肪細胞のインスリン依存性糖輸送機構における新規Akt基質の生理的意義2014
- Author(s)
  曽根芽里、笠原浩平、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS-1 promotes embryonic growth of zebrafish through IGF-IR signal-dependent and -independent mechanisms in response to developmental stages and environmental oxygen availability2014
- Author(s)
  Hiroyasu Kamei, Rie Sawada, Yosuke Yoneyama, Fumihiko Hakuno, Toshiaki Shimizu, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGF-1を知る～アクロメガリー診療への扉～　IGF-1活性とその調節2014
- Author(s)
  高橋伸一郎
- Organizer
  第10回アクロメガリーフォーラム
- Place of Presentation
  京都
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Evolution of insulin-like peptides2014
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
- Place of Presentation
  Nakashima Hall, The University of Tokyo, Tokyo
- Year and Date
  2014-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Constitutive IRS1 expression causes cell competition, leading to defect in myogenic differentiation2014
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Atsufumi Ozoe and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phospho-tyrosine independent roles of insulin receptor substrates2014
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
- Place of Presentation
  Nakashima Hall, The University of Tokyo, Tokyo
- Year and Date
  2014-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of insulin receptor substrate-1 in catch-up growth: A lesson from tiny fish embryo2014
- Author(s)
  Hiroyasu Kamei and Shin-Ichiro Takahashi
- Organizer
  Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
- Place of Presentation
  Nakashima Hall, The University of Tokyo, Tokyo
- Year and Date
  2014-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 complexes enhance IGF-I signals, and their roles in IGF-I action in prostate cancer cell proliferation2014
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 低タンパク質食給餌ラットから単離した肝細胞ではインスリン依存性acetyl-CoA carboxylase 遺伝子発現が増強する2014
- Author(s)
  田口雄亮、豊島由香、時田玲子、加藤久典、高橋伸一郎、南史朗
- Organizer
  第68回日本栄養・食糧学会
- Place of Presentation
  酪農学園大学・札幌
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Mechanisms for Regulation of Acetylation of Insulin-Receptor Substrate (IRS)-1, Regulating Insulin-Like Growth Factor (IGF) Signaling2014
- Author(s)
  Kumiko Fujieda, Yosuke Yoneyama, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ICE/ENDO 2014
- Place of Presentation
  McComick Place West, Chicago Illinois, USA
- Year and Date
  2014-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IRS1を恒常的発現したL6筋芽細胞は、細胞競合を引き起こし、筋分化が抑制される2014
- Author(s)
  伯野史彦、米山鷹介、臼井杏美、尾添淳文、高橋伸一郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸欠乏培地で培養した肝細胞ではインスリン受容体基質（IRS）-2量が増加し脂肪蓄積が起こる2014
- Author(s)
  森友美、亀井宏泰、赤西成美、尾添淳文、伯野史彦、千田和広、加藤久典、豊島由香、竹中麻子、高橋伸一郎
- Organizer
  日本農芸化学会大会2014年度
- Place of Presentation
  川崎
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGFシグナルに応答して変動するユビキチン化タンパク質の網羅的解析2014
- Author(s)
  吉原英人、土屋光、吉田雪子、田中啓二、高橋伸一郎、佐伯泰
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 甲状腺細胞の増殖に必須なアダプタータンパク質PI3KAPの遺伝子欠損は甲状腺機能を低下させる2014
- Author(s)
  山中大介、伯野史彦、南史朗、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Interaction between insulin receptor substrates (IRSs) and various proteins including diacylglycerol kinase ζ (DGKζ) modulates insulin bioactivities2014
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  invited lectures by Sichuan University
- Place of Presentation
  Sichuan University, Chengdu, China
- Year and Date
  2014-11-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells2014
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構2014
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] アミノ酸シグナルとインスリン様活性－低タンパク質栄養状態に応答した成長遅滞と脂肪肝誘導の仕組み2014
- Author(s)
  高橋伸一郎
- Organizer
  早稲田大学先進理工学研究科生命医科学講演会
- Place of Presentation
  東京
- Year and Date
  2014-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing2014
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Loss of PI 3-kinase-binding protein PI3KAP/XB130 suppresses thyroid function and induces enlargement of thyroid glands in mice2014
- Author(s)
  Daisuke Yamanaka, Fumihiko Hakuno, Shiro Minami, Koshi Hashimoto, Kouichi Suzuki, Kazuhiro Chida, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] ゼブラフィッシュの初期発生におけるphosphatidylinositol 3-kinase（PI3K）の新規結合タンパク質の役割2014
- Author(s)
  川内啓希、山中大介、亀井宏泰、南史朗、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] IGF-1活性とその調節2014
- Author(s)
  高橋伸一郎
- Organizer
  第10回アクロメガリーフォーラム
- Place of Presentation
  京都
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] ゼブラフィッシュを用いたSHOX（short stature homeobox containing）遺伝子の胚発生における役割の解析2014
- Author(s)
  山口里恵、亀井宏泰、伯野史彦、高橋伸一郎、清水俊明
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] ユビキチンリガーゼNedd4がIRS-2を介したIGFシグナルを増強する新しい分子機構2014
- Author(s)
  福嶋俊明、吉原英人、古田遥佳、伯野史彦、佐伯泰、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phospho-tyrosine independent roles of insulin receptor substrates2014
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  International Seminar “Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing” sponsored by Core-to-Core Project
- Place of Presentation
  東京
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Lipopolysaccharide (LPS) treatment increased the protein levels of GKAP42 (42-kDa cGMP-dependent protein kinase anchoring protein) followed by inhibition of glucose transporter (GLUT) 4 translocation to the plasma membrane and glucose uptake in adipocytes2014
- Author(s)
  Bu Chin Yu, Yasutoshi Ando, Yuko Obata, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 低酸素環境で成長が遅滞したゼブラフィッシュ胚が常酸素環境で追いつき成長を起こす機構の解明：インスリン受容体基質（IRS）-1の機能2014
- Author(s)
  亀井宏泰、山口里恵、米山鷹介、伯野史彦、清水俊明、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン抵抗性発生の新しい機序としてのGLUT4のセリンリン酸化2014
- Author(s)
  高橋伸一郎、久保真実子、渡部千尋、笠原浩平、曽根芽里、千田和広、伯野史彦
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム、東京
- Year and Date
  2014-04-11
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis.2013
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Intracellular localization of insulin receptor substrates determines exerted insulin-like activities2013
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Obesity, Diabetes and Cancer: the roles of insulin and insulin-like growth factors
- Place of Presentation
  Taormina, Italy
- Year and Date
  2013-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phosphoglycerate-mutase 5 (PGAM5) is involved in dephosphorylation of insulin receptor substrates (IRSs) and controlling insulin-like activities2013
- Author(s)
  Junichi Inobe, Toshiaki Fukushima, Akihiro Ito, Yukako Kida, Takashi Shiano, Kazuhiro Chida, Minoru Yoshida, Tomoichiro Asano, Kouske Takeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Novel mechanisms for the expression of insulin/IGF bioactivities by IRS-1-RNA complex2013
- Author(s)
  Atsufumi Ozoe, Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease: From Pathophysiology to Targeted Therapy”
- Place of Presentation
  Karolinska Institute, Stockholm, Sweden
- Invited
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Constitutive IRS-1 expression suppressed cell invasion, leading to inhibition of myogenesis in L6 myoblasts2013
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and disease
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] IRSome: novel complexes to mediate/modulate insulin-like activitie2013
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease: From Pathophysiology to Targeted Therapy”
- Place of Presentation
  Karolinska Institute, Stockholm, Sweden
- Invited
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Shin-Ichiro Takahashi
- Organizer
  EMBO Conference"Ubiquitin and ubiquitin-like proteins : from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] 物質代謝制御におけるインスリン様成長因子とインスリンの連携2013
- Author(s)
  高橋伸一郎
- Organizer
  低タンパク質栄養状態に応答したタンパク質代謝と糖代謝の内分泌制御シンポジウム「栄養と内分泌・代謝」第86回日本内分泌学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2013-04-27
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Regulation of intracellular localization of insulin receptor substrate (IRS) proteins and insulin-like activities. Obesity, Diabetes and Cancer2013
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  the roles of insulin and insulin-like growth factors
- Place of Presentation
  Taormina, Italy
- Year and Date
  2013-08-04
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Molecular mechanisms of porentiation of insulin-like growth factors (IGFs) bioactivity by other extracellular factors2013
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Department Lecture at Arizona State University
- Place of Presentation
  Tempe Phoenix, AZ, USA
- Year and Date
  2013-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Identification of proteins proximal to insulin receptor substrate (IRS)-1 in the intracellular vesicle compartment2013
- Author(s)
  Yosuke Yoneyama, Akihiro Ito, Kazuhiro Chida, Minoru Yoshida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: Insulin-like growth factors in physiology and diseases
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis2013
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体基質（IRS）-1のアセチル化酵素と脱アセチル化酵素の特定2013
- Author(s)
  藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Constitutive IRS1 expression suppressed cell invasion and migration, leading to inhibition of myogenesis in L6 myoblasts.2013
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Kazuhiro Chida, Shin-Ichiro Takahashi.
- Organizer
  American Society of Cell Biology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling2013
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference “Ubiquitin and ubiquitin-like proteins: from structure to function
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of insulin receptor substrate-1 interacting with clathrin adaptor AP-2 complex at submembranous actin cytoskeleton2013
- Author(s)
  Yosuke Yoeneyama, Kazuhiro Chida, Fumihiko Hakuno , Shin-Ichiro Takahashi.
- Organizer
  American Society of Cell Biology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] 低タンパク質食摂取がインスリン受容体基質(IRS)-2 に及ぼす影響の解析2013
- Author(s)
  丸井未槻、日野美佳、金子梨紗、尾崎依、吉原英人、亀井宏泰、伯野史彦、高橋伸一郎、竹中麻子
- Organizer
  第5回日本アミノ酸学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2013-07-26
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Regulation of intracellular localization of insulin receptor substrate (IRS) proteins and insulin-like activities2013
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Obesity, Diabetes and Cancer: the roles of insulin and insulin-like growth factors
- Place of Presentation
  Taormina, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] GLUT4の糖膜透過能活性化におけるGLUT4セリン488番目のリン酸化の役割2012
- Author(s)
  久保真実子、笠原浩平、曽根芽里、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] GLUT4の糖膜透過能活性化におけるGLUT4セリン488番目のリン酸化の役割2012
- Author(s)
  久保真実子、笠原浩平、曽根芽里、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] Appeasing pheromone mediates social buffering of conditioned fear responses.2012
- Author(s)
  Kiyokawa Y, Takahashi Y, Takeuchi Y, Mori Y.
- Organizer
  The 21th Annual Meeting of the International Behavioral Neuroscience Society
- Place of Presentation
  Kailua-Kona, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21228006
[Presentation] Diacylglycerol kinase ζ , a novel binding partner of insulin receptor substrates, negatively modulated GLUT4 translocation in 3T3-L1 adipocytes.2012
- Author(s)
  Hakuno F, Ando Y, Kakino M, Fujimoto H, Chida K, Takahashi SI
- Organizer
  6rh GRS-IGF 2012
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] Olfactory signals mediate social buffering of conditioned fear responses in male rats.2012
- Author(s)
  Kiyokawa Y, Takahashi Y, Takeuchi Y, Mori Y.
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-21228006
[Presentation] Diacylglycerol kinase ζ, a novel binding partner of insulin receptor substrates, negatively modulated GLUT4 translocation in 3T3-L1 adipocytes.2012
- Author(s)
  Hakuno F, Ando Y, Kakino M, Fujimoto H, Chida K, Takahashi SI
- Organizer
  6rh GRS-IGF 2012
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent proliferation2012
- Author(s)
  Yosuke Yoneyama, Satoshi Yoshinaga, Masao Matsuo, Kazumi Take, Tomohiro Kabuta, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-18
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Diacylglycerol kinase ζ, negatively modulated GLUT4 translocation in 3T3-L1 adipocytes2012
- Author(s)
  Hakuno F, Ando Y, Kakino M, Fujimoto H, Chida K, Takahashi SI
- Organizer
  6^th GRS-IGF
- Place of Presentation
  Munich, Germany.
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] Ubiquitin ligase Nedd4 interacts with insulin receptor substrate (IRS)-2 in response to humoral/nutritional stimuli, thereby enhancing IRS-2-mediated IGF/insulin signals through a novel mechanism2012
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Hideyuki Sakoda, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors (IGFs)2011
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Kazuhiro Chida, Tomoichiro Asano, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference"Insulin-like Growth Factors in Physiology & Disease"
- Place of Presentation
  Ventura CA, USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン様成長因子とインスリンの単独プレイと連携プレイ2011
- Author(s)
  高橋伸一郎
- Organizer
  内分泌代謝学サマーセミナー(招待講演)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] インスリン様成長因子とインスリンの単独プレイと連携プレイ2011
- Author(s)
  高橋伸一郎
- Organizer
  第29回内分泌サマーセミナー
- Place of Presentation
  東北大学、仙台
- Year and Date
  2011-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] 成長ホルモンによるインスリン抵抗性発生機構とその補償機構2011
- Author(s)
  高橋伸一郎
- Organizer
  第15回日本内分泌病理学会総会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] インスリン様ペプチドの進化と生理的意義2011
- Author(s)
  高橋伸一郎
- Organizer
  第29回千駄木内分泌懇話会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] 肝細胞においてNedd4はインスリン受容体基質(IRS)-2のユビキチン化を介してインスリンシグナルを増強する2011
- Author(s)
  福嶋俊明,吉原英人,伯野史彦,佐伯泰,田中啓二,伊藤昭博,中津祐介,鎌田英明,高橋伸一郎,浅野知一郎
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(口頭発表、ポスター発表)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン様成長因子とインスリンの単独プレイと連携プレイ2011
- Author(s)
  高橋伸一郎
- Organizer
  内分泌代謝学サマーセミナー
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] インスリン様ペプチドの進化と生理的異議2011
- Author(s)
  高橋伸一郎
- Organizer
  第29回千駄木内分泌懇話会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-23658222
[Presentation] Effects of oxidative stress on insulin signaling and bioactivities2010
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  The 26th Kumamoto Medical Bioscience Symposium
- Place of Presentation
  Kumamoto
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] 進化から学ぶIGF/インスリンシステムの生理的意義2010
- Author(s)
  高橋伸一郎
- Organizer
  GH/IGF-I & Longevity Meeting
- Place of Presentation
  東京
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] IGF活性を修飾する機構の多様性2010
- Author(s)
  高橋伸一郎
- Organizer
  Forum on Grwoth Hormone Research 2010
- Place of Presentation
  東京
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] IGFの多彩な生理活性とその発現機構2008
- Author(s)
  高橋伸一郎
- Organizer
  臨床内分泌代謝Update
- Place of Presentation
  高知、日本
- Year and Date
  2008-03-15
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] IGFの多彩な生理活性とその発現機構2008
- Author(s)
  高橋伸一郎
- Organizer
  臨床内分泌代謝Update
- Place of Presentation
  高知
- Year and Date
  2008-03-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] The Novel Roles of Liver for Compensation of Insulin Resistance in Human Growth Hormone Transgenic Rats2006
- Author(s)
  Shjn-Ichiro Takahashi
- Organizer
  3rd International Congress of GRS-IGF Society
- Place of Presentation
  Kobe
- Year and Date
  2006-11-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] インスリン様成長因子の新しい作用発現調節機構2006
- Author(s)
  高橋伸一郎
- Organizer
  第24回内分泌代謝学サマーセミナー
- Place of Presentation
  逗子
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] A lifelong need of growth hormone and insu1in-1ike growth factors2006
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  2nd Meeting of Asian Society of Pediatric Research
- Place of Presentation
  Yokoham
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] A lifelong need of growth hormone and insulin-like growth factors2006
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  2nd Meeting of Asian Society of Pediatric Research Invited Luncheon Seminar, invited lecture
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] 動物の一生とインスリン様成長因子2005
- Author(s)
  高橋伸一郎
- Organizer
  第78回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2005-06-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] インスリン受容体基質IRSの細胞内局在とその機能2005
- Author(s)
  高橋伸一郎
- Organizer
  第11回Novo-Nordisk Growth研究会
- Place of Presentation
  東京
- Year and Date
  2005-06-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] インスリン様活性を調節する新しい細胞内メ力ニズム-基質を介して形成されるシグナル分子複合体の新機能2004
- Author(s)
  高橋伸一郎
- Organizer
  第8回小児内分泌研究会
- Place of Presentation
  富良野
- Year and Date
  2004-07-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] インスリン様活性を調節する新しい細胞内メカニズム・基質を介して形成されるシグナル分子複合体の新機能2004
- Author(s)
  高橋伸一郎
- Organizer
  第8回小児内分泌研究会
- Place of Presentation
  富良野
- Year and Date
  2004-07-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] インスリンレセプター基質(IRS)を介した新しいインスリンシグナル修飾機構2004
- Author(s)
  高橋伸一郎
- Organizer
  熊本分子病態研究会
- Place of Presentation
  熊本
- Year and Date
  2004-09-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16208028
[Presentation] Interaction between insulin receptor substrates (IRSs) and various proteins including diacylglycerol kinase  (DGK) modulates insulin bioactivities
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Post-International Conference on Food Factors (ICoFF) Workshop “Food Factors forPreventing the Metabolic Syndrome”
- Place of Presentation
  Tainan
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of insulin receptor substrate-1 interacting with clathrin adaptor AP-2 complex at submembranous actin cytoskeleton
- Author(s)
  Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  2013 ASCB Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2013-12-14 – 2013-12-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Nedd4-IRS2複合体の形成機構と複合体ががん細胞の過増殖誘導に果たす役割
- Author(s)
  福嶋俊明、吉原英人、古田遥佳、伯野史彦、千田和広、佐伯泰、田中啓二、伊藤昭博、吉田稔、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Novel mechanisms for the expression of insulin/IGF bioactivities by IRS-1-RNA complex
- Author(s)
  Atsufumi Ozoe, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-16
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 物質代謝制御におけるインスリン様成長因子とインスリンの連携：低タンパク質栄養状態に応答したタンパク質代謝と糖代謝の内分泌制御
- Author(s)
  高橋伸一郎
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Analysis of expression of insulin receptor isoforms
- Author(s)
  Yuka Narita, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体基質はG3BP1と相互作用し、cap非依存的なBcl-2 mRNAの翻訳を正に制御する
- Author(s)
  尾添淳文、曽根芽里、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] IRSome: novel complexes to mediate/modulate insulin-like activities
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease: From Pathophysiology to Targeted Therapy”
- Place of Presentation
  Stockholm, Sweden
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback loop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshiaki Fukushima, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Shunichiro Iemura, Tohru Natsume, Tomoichiro Asano, Kazuhiro Chida, Leonard Girnita, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback llop in insulin/IGF signaling
- Author(s)
  Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
- Organizer
  EMBO Conference
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2013-10-01 – 2013-10-05
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 物質代謝制御におけるインスリン様成長因子とインスリンの連携
- Author(s)
  高橋伸一郎
- Organizer
  日本内分泌学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-25252047
[Presentation] Insulin receptor substrates (IRSs) form complex with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulating cap-independent translation of Bcl-2 mRNA.
- Author(s)
  Atufumi Ozoe, Meri Sone, Toshiaki Fukushima, Naoyuki Kataoka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Diacylglycerol kinase ζ (DGKζ) and PIP5K1α cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes
- Author(s)
  Hakuno F, Liu TY, Kakino M, Fujimoto H, Ando Y, Chida K, Takahashi SI.
- Organizer
  Gordon Conference
- Place of Presentation
  Ventura in USA
- Year and Date
  2015-03-08 – 2015-03-12
- Data Source
  KAKENHI-PROJECT-24380152
[Presentation] A deubiquitinating enzyme, USP7, is associated with IRS-2 forming a negative feedback loop in IGF signaling
- Author(s)
  Hidehito Yoshihara, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Regulation of insulin-like activities and their physiological significance
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  International Seminar “Insulin-like activities and their related-diseases in aging from the aspects of basic and translational medicine”
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Lipopolysaccharide (LPS) treatment increased the protein levels of GKAP42 (42-kDa cGMP-dependent protein kinase anchoring protein) followed by inhibition of glucose transporter (GLUT) 4 translocation to the plasma membrane and glucose uptake in adipocytes
- Author(s)
  Bu-Chin Yu, Yasutoshi Ando, Yuko Obata, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-13F03089
[Presentation] 動物の一生におけるインスリン様活性の役割
- Author(s)
  高橋伸一郎
- Organizer
  第8回アンチエイジング静岡コンファレンス
- Place of Presentation
  静岡
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  7th International Congress of the GRS and IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Functional analysis of ubiquitin specific protease USP9X which interacts with IRSs.
- Author(s)
  Haruka Furuta, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン様成長因子とインスリンの単独プレイと連携プレイ
- Author(s)
  高橋伸一郎
- Organizer
  第29回内分泌サマーセミナー
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] IRS結合タンパク質、DGKζを介した新しい糖取り込みの調節機構
- Author(s)
  劉亭妤、柿野衛、冨士本仁、伊藤昭博、吉田稔、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] がん細胞では、脱ユビキチン化酵素USP9XによりIGF-I受容体およびIRS-2の分解が抑制され、IGF依存性増殖が亢進している
- Author(s)
  古田遥佳、吉原英人、福嶋俊明、佐伯泰、田中啓二、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構
- Author(s)
  成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] Kynote lecture: IRSome: novel complexes to mediate/modulate insulin-like activities
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-16
- Invited
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] インスリン様ペプチドの進化と生理的意義
- Author(s)
  高橋伸一郎
- Organizer
  第29回千駄木内分泌懇話会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis
- Author(s)
  Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  ENDO2013
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] ユビキチン結合ドメインタンパク質によるユビキチンシグナルの発動メカニズム
- Author(s)
  吉原英人、海保愛、新井直子、土屋光、高橋伸一郎、田中啓二、佐伯泰
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11 – 2013-09-13
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 成長ホルモンによるインスリン抵抗性発生機構とその補償機構
- Author(s)
  高橋伸一郎
- Organizer
  第15回日本内分泌病理学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Regulation of intracellular localization of insulin receptor substrate (IRS) proteins and insulin-like activities
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Obesity, Diabetes and Cancer: the roles of insulin and insulin-like growth factors
- Place of Presentation
  Taormina, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA.
- Author(s)
  Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF & Insulin System in Physiology & Disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-25660210
[Presentation] IRS-1 expression suppressed cell invasion, leading to inhibition of myogenesis.
- Author(s)
  Fumihiko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130 crosslinks actin filaments and regulates cell migration
- Author(s)
  Daisuke Yamanaka, Takeshi Akama, Fumihiko Hakuno, Kazuhiro Chida, Kouichi Suzuki, Shiro Minami, and Shin-Ichiro Takahashi
- Organizer
  The 6th Interntional Congress of the GRS-IGF Society
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] ミトコンドリア局在型フォスファターゼPGAM5は、インスリン受容体基質のセリン／スレオニンリン酸化と安定性の調節に機能している
- Author(s)
  米山鷹介、鋳延淳一、木田友佳子、福嶋俊明、関根史織、浅野知一郎、千田和広、武田弘資、伯野史彦、高橋伸一郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] Molecular mechanisms of potentiation of insulin-like growth factors (IGFs) bioactivities by other extracellular factors
- Author(s)
  Shin-Ichiro Takahashi
- Organizer
  Invited seminar of Arizona State University
- Place of Presentation
  Tempe, Phoenix, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] インスリン受容体基質―Rabankyrin-5複合体がインスリン様成長因子で誘導されるマクロピノサイトーシスに果たす役割の検討
- Author(s)
  矢野貴之、米山鷹介、松井利晃、岡嶋裕志、千田和広、伯野史彦、高橋伸一郎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Constitutive IRS1 expression suppressed cell invasion and migration, leading to inhibition of myogenesis in L6 myoblasts
- Author(s)
  Fumihiko Hakuno, Yosuke Yoneyama, Kazuhiro Chida, Shin-Ichiro Takahashi
- Organizer
  2013 ASCB Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2013-12-14 – 2013-12-18
- Data Source
  KAKENHI-PROJECT-25221204
[Presentation] 新規PI 3-kinase結合タンパク質PI3KAP/XB130は、TSHとIGFによる甲状腺細胞の相乗的増殖誘導に必須である
- Author(s)
  山中大介、赤間剛、福嶋俊明、南史朗、伯野史彦、高橋伸一郎
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22248030
[Presentation] Ubiquitin-conjugation to IRS by ubiquitin ligase Nedd4 drives Insulin/IGF signaling
- Author(s)
  Toshiaki Fukushima, Fumihko Hakuno and Shin-Ichiro Takahashi
- Organizer
  INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2013-08-12 – 2013-08-16
- Data Source
  KAKENHI-PROJECT-25221204

1. HAKUNO Fumihiko (30282700)

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44. Hanaki Keiichi (20238041)

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45. Kanzaki Susumu (90224873)

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46. Nanba Eiji (40237631)

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47. Adachi Kaori (50609237)

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48. SHIOYA Ryuji (70282689)

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49. 梅原崇史 (20415095)

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50. 河本馨 (30011894)

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51. 舘鄰 (30011711)

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52. 今井英明 (70359587)

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53. 武笠晃丈 (90463869)

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54. 宮脇哲 (70407914)

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55. Chida Kazuhiro

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56. Yamanaka Daisuke

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57. Asano Tomoichiro

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58. Takenaka Asako

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59. OZOE Atsufumi

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60. UNDERWOOD Louis e.

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61. BAXTER Robert C.

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62. Fujimoto Masanobu

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63. Hasegawa Akiko

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64. 高橋仲一郎

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65. Higashi Yusuke

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66. Girnita Leonard

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67. Torres-Aleman Ignacio

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68. Duan Cunming

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69. Weghuber Julian

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70. Belfiore Antonino

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71. O'Connor Rosemary

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72. Forbes Briony

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73. VANWYK Judson j.

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74. BOYAGES Stev

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75. WYK Judson J.Van

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76. BOYAGES Steven C.

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77. CLLEMMONS Da

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78. ボエージズティーヴン・

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79. コンティマルコ

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80. バクスターロバート・C

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81. クレモンズデーヴィット

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82. ヴァンワイクジャドソン

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83. D Ercole A.J

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84. VANWYK Judso

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85. KUSHIYAMA Akifumi

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86. Masuda Masato

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87. NATSUME Tohru

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88. NAKATSU Yusuke

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89. ONO Hiraku

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90. SAKODA Hideyuki

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91. SUZUKI Yuka

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92. KAMEI Hiroyasu

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93. KATO Hisanori

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94. 徳永文稔

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95. 鎌田英明

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96. 岩井一宏

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97. 吉田稔

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98. 駒田雅之

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99. 米山鷹介

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100. 中林靖

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101. 伊庭英生

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102. 小西守周

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103. 昆彩奈

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104. 小川誠司

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105. 株田智弘

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106. 石原寿光

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107. 藤城緑

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108. 兼松隆

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109. 山脇洋輔

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110. 山本屋武

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111. 佐野朋美

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112. 西村英紀

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113. 大野晴也

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114. 浅野智志

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115. 高橋圭

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116. 片桐秀樹

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117. 山田哲也

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118. 鈴木幸一

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119. 根建拓

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120. 増澤・尾崎依

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121. 前田達哉

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122. 田中啓二

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123. CONTU VIORICA

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124. 和田圭司

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Takahashi Shinichiro 高橋 伸一郎

TAKAHASHI Shin-ichiro 高橋 伸一郎

TAKAHASHI SHINICHIRO 高橋 紳一郎

Research Projects

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Co-Researchers

インスリン受容体基質のユビキチン修飾の制御機構とその生理的・病態的意義の解明Principal InvestigatorOngoing

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Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significancePrincipal Investigator

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チアゾリジン化合物のＰＰＡＲγ非依存性経路を介した新規インスリン作用増強剤の開発Host Researcher

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Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complexPrincipal Investigator

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動物の一生において時期・組織特異的にインスリン様活性を制御する新規機構とその意義Principal Investigator

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Identification and elucidation of the roles of RNAs associated with insulin receptor substratePrincipal Investigator

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Isolation of drugs which rescue insulin resistance by activating GLUT4 transport activity.Principal Investigator

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Novel mechanisms of growth regulation through changes in ubiquitination of insulin receptor substratesPrincipal Investigator

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Takahashi Shinichiro 高橋伸一郎

TAKAHASHI Shin-ichiro 高橋伸一郎

TAKAHASHI SHINICHIRO 高橋紳一郎