UTSUNOMIYA-TATE Naoko 楯直子

… Alternative Names

楯直子タテナオコ

TATE Naoko 楯直子

UTSUNOMIYA Naoko

宇都宮直子ウツノミヤナオコ

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Researcher Number	00201955
Other IDs
Affiliation (Current)	2025: 帝京大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 帝京大学, 薬学部, 教授・学部長 2021 – 2023: 帝京大学, 薬学部, 教授 2012: 帝京大学, 薬学部, 教授 2009 – 2011: Musashino University, 薬学研究所, 教授 2003: Nippon Veterinary and Animal Science University, Veterinary, Associate, 獣医学部, 助教授 … More 2001 – 2002: 日本獣医畜産大学, 獣医畜産学部, 助教授 1998: 杏林大, 医学部, 助手 1995 – 1998: Kyorin University, School of Medicine, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological pharmacy Except Principal Investigator General pharmacology / Biological pharmacy
Keywords	Principal Investigator 構造 / アミロイドβペプチド / アルツハイマー病 / トランスポーター / アミノ酸 / 老化 / マルチリガンド受容体RAGE / アミノ酸の異性化 / 凝集体 / 線維形成 … More / D-Asp / 異性化アミノ酸 / アミロイドβ / structure / complex / Reelin / neuron / 層構造 / 円偏光二色性 / 会合体 / リーリン / 神経細胞 / 神経細胞毒性 / 物性 / 老年性脳疾患 / 老人斑 / アミロイドβペブチド / Aβフラグメント / アミロイドβペプチド(Aβ) / D-アミノ酸 / 凝集 / 線維化 / リンパ球 / マクロファージ / システイン / 免疫 / T細胞 / 腫瘍細胞 … More Except Principal Investigator トランスポーター / 膜輸送 / グルタミン酸 / アミノ酸 / Transporter / クローニング / トランスポータ / cystine / 酸化的ストレス / シスチン / Central nervous system / Glutamate / multispecific substrate recognition / carnitine transporter / organic cation transporter / ochratoxin A / estron sulfate / para-amino hippurate / organic anion transporter / organic anion / 薬物輸送 / ジカルボン酸トランスポーター / ジカルボン酸 / 近位尿細管中間部 / 多選択性基質認識 / カルニチントランスポーター / 有機カチオントランスポーター / オクラトキシンA / エストロン硫酸 / パラアミノ馬尿酸 / 有機アニオントランスポーター / 有機アニオン / Molewlar Pharmawlogy / cysteine / oxidative stress / amino acids / Membrane transport / グリオーマ / 神経細胞 / 分子薬理学 / 中枢神経 / システイン / Protection / Cloning / Oxidative Stress / amino acid / 交換輸送 / cDNAクローニング / 輸送担体 / 生体防御 / membrane transport / excitotoxicity / neurotoxicity / neuro transmission / 興奮毒性 / 神経毒性 / 神経伝達 / 中枢神経系 / 気道上皮細胞 / アレルギー・せんそく / アレルギー・喘息 / 細胞・組織 / 薬学 / 老化 / アレルギー・ぜんそく / キメラ解析 / 輸送 / グルタミン酸トランスポータ / 構造機能相関 / 神経伝達物質 Less

The physicochemical analysis of amyloid peptide containing D-AspPrincipal Investigator
- Principal Investigator
  
  UTSUNOMIYA-TATE Naoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Teikyo University
Bronchial epithelial cells as the targets of the therapy for refractory asthma of elderly patients.
- Principal Investigator
  
  YAMASHITA Naomi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Musashino University
The mechanism of amyloid fibril formation induced by D-amino acidsPrincipal Investigator
- Principal Investigator
  
  TATE Naoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Musashino University
The Mechanism of the formation of Reelin complexPrincipal Investigator
- Principal Investigator
  
  TATE Naoko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nippon Veterinary and Animal Science University
グルタミン酸トランスポータファミリーの基質透過とチャネル形成の分子機房の解明
- Principal Investigator
  
  金井好克
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
T細胞機能の酸化還元的制御に関わるアミノ酸トランスポーターの同定Principal Investigator
- Principal Investigator
  
  楯直子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyorin University
New roprorective roles of amino acid transporrers
- Principal Investigator
  
  KANAI Yoshikatdu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
Molecular cloning and functional expression of kidney-specific organic anionic drug transporters
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University School of Medicine
グルタミン酸トランスポータファミリーの構造機能相関の解析
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
T細胞機能の酸化還元的制御に関わるアミノ酸トランスポーターの同定Principal Investigator
- Principal Investigator
  
  楯直子 (宇都宮直子)
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyorin University
Roles of glutamate transporters in the nervous system
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyorin University
Molecular identification of cystine / glutamate exchanger
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University

All 2024 2023 2022 2021 2012 2011 2010 2009 Other

All Journal Article Presentation Book Other

[Book] 薬学生の物理化学2021
- Author(s)
  楯　直子・平嶋尚英
- Total Pages
  270
- Publisher
  培風館
- Data Source
  KAKENHI-PROJECT-21K06498
[Journal Article] A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.2023
- Author(s)
  Sato W., Watanabe-Takahashi M., Murata T., Utsunomiya-Tate N., Motoyama J., Anzai M., Ishihara S., Nishioka N., Uchiyama H., Togashi J., Nishihara S., Kawasaki K., Saito T., Saido TC., Funamoto S., Nishikawa K.
- Journal Title
  
  Commun. Biol.
  
  Volume: 6 Issue: 1 Pages: 383-383
- DOI
  10.1038/s42003-023-04771-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06498
[Journal Article] Adverse drug event profile associated with anti-dementia drugs analysis of a spontaneous reporting database.2023
- Author(s)
  E. Kose, T. Yamamoto, N. Utsunomiya-Tate, A. Ando, H. Enomoto, N. Yasuno
- Journal Title
  
  Pharmazie
  
  Volume: 78 Pages: 42-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06498
[Journal Article] Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency.2023
- Author(s)
  Murata T., Ito, G. and Utsunomiya-Tate, N.
- Journal Title
  
  Biochem. Biophys, Res. Commun.
  
  Volume: 654 Pages: 18-25
- DOI
  10.1016/j.bbrc.2023.02.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06498, KAKENHI-PROJECT-21K06558
[Journal Article] D-Ser containing hymanin shows promotion of fibril formation2012
- Author(s)
  Hayashi, K., Sasabe, J., Chiba, T., Aiso, S. and Utsunomiya-Tate, N
- Journal Title
  
  Amino Acids
  
  Volume: 42 Pages: 2293-2297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590080
[Journal Article] Controlled structure and properties of silicate nanoparticle networks for incorporation of biosystem components2011
- Author(s)
  Sakai-Kato, K., Hasegawa, T., Takaoka, A., Kato, M, Toyo'oka, T., Utsunomiya-Tate, N. and Kawanishi, T
- Journal Title
  
  Nanotechnology
  
  Volume: 22 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590080
[Journal Article] Collagen racemization and deposition in the lungs of aged rats2010
- Author(s)
  Kasai, A., Yamashita, N. and Utsunomiya-Tate, N
- Journal Title
  
  Biochemistry Insights
  
  Volume: 3 Pages: 25-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590080
[Journal Article] Collagen racemization and de@position on the lung of aged rats2010
- Author(s)
  Kasai A, Yamashita N, Utsunomiya-Tate N
- Journal Title
  
  Biochemistlry Insight
  
  Volume: 3 Pages: 25-33
- Data Source
  KAKENHI-PROJECT-22590075
[Journal Article] Stability of folding structure of Zic zinc finger proteins2009
- Author(s)
  Sakai-Kato, K., Umezawa, Y., Mikoshiba, K., Aruga, J. and Utsunomiya-Tate, N
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 384 Pages: 362-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] アミノ酸のD-体異性化がアミロイドβのシード効果に及ぼす影響の解析2024
- Author(s)
  村田拓哉、楯　直子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] タウ線維化にアミノ酸D-体異性化が及ぼす影響の解析2023
- Author(s)
  村田拓哉、伊藤弦太、楯　直子
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] Aβの産生ならびに凝集を抑制する多価型ペプチドの同定2022
- Author(s)
  佐藤和佳、高橋美帆、村田拓哉、楯　直子、内山陽菜、斉藤貴志、西道隆臣、舟本聡、西川喜代孝
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] タウ微小管結合領域におけるアミノ酸D-体異性化と線維化・凝集体形成の相関関係の解析2022
- Author(s)
  村田拓哉、大塚遥菜、矢萩真菜、国生莉奈、伊藤弦太、楯　直子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] 変異型α-synuclein；30PおよびA53Eの線維形成プロセスの解析2022
- Author(s)
  村田拓哉、小嶋淳也、吉根直加、小澤雅史、楯　直子
- Organizer
  第142回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] タウのD-アミノ酸が線維形成に及ぼす影響の解析2022
- Author(s)
  村田拓哉、矢萩真菜、国生莉奈、楯　直子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] 家族性パーキンソン病を惹起する変異型α-synucleinの構造と線維形成の解析2021
- Author(s)
  村田拓哉、小嶋淳也、吉根直加、小澤雅史、楯　直子
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06498
[Presentation] 正常型HumaninおよびD-Ser含有Humaninの構造・物性に関する研究2011
- Author(s)
  林周宏、楯直子
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] D-アスパラギン酸含有アミロイドβペプチドの線維・凝集体形成および神経細胞毒性に関する解析2011
- Author(s)
  林周宏、大平麻里、楯直子
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] D-アスパラギン酸含有アミロイドβペプチドの線維・凝集体形成および神経細胞毒性に関する解析2011
- Author(s)
  林周宏、楯直子
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] D-Asp含有改変型アミロイドβペプチドの神経細胞毒性に関する研究2010
- Author(s)
  楯直子
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山大学(岡山県)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] Preferential domain orientation in HMGB2 protein revealed by NMR spectroscopy2010
- Author(s)
  Uewaki, J., and Utsunomiya-Tate, N
- Organizer
  PACIFICHEM2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] アミロイドβペプチドのアスパラギン酸残基異性化置換による線維化・凝集機構における構造機能相関解析2010
- Author(s)
  楯直子
- Organizer
  日本生化学会第83回大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] Influence of amino acid isomerization on proteins, which cause senescence-related diseases2009
- Author(s)
  Moriuchi, H. and Utsunomiya-Tate, N
- Organizer
  The 1^<st> international conference of D-amino acid research
- Place of Presentation
  Awaji Yumebutai International Conference Center(Awaji, Hyougo, Japan)
- Year and Date
  2009-07-02
- Data Source
  KAKENHI-PROJECT-21590080
[Presentation] Analysis of structure stability of HMGB22009
- Author(s)
  森内寛、楯直子
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アクティ徳島(徳島)
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21590080
[]
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1. KANAI Yoshikatsu (60204533)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. ENDOU Hitoshi (20101115)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAKEDA Michio (40255401)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HOSOYAMADA Makoto (00291659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SEKINE Takashi (50255402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HEDIGER Matt

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASHITA Naomi (20239974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TAKAHASHI Naoyuki (20337447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. CHA Seok ho (50276200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. INATOMI Jun (00311960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NUSSBERGER Stephan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HEDIGEL Matthias a

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TROTTI David

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UTSUNOMIYA-TATE Naoko 楯 直子

楯 直子 タテ ナオコ

TATE Naoko 楯 直子

UTSUNOMIYA Naoko

宇都宮 直子 ウツノミヤ ナオコ

Research Projects

Research Products

Co-Researchers

The physicochemical analysis of amyloid peptide containing D-AspPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bronchial epithelial cells as the targets of the therapy for refractory asthma of elderly patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of amyloid fibril formation induced by D-amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Mechanism of the formation of Reelin complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グルタミン酸トランスポータファミリーの基質透過とチャネル形成の分子機房の解明

Principal Investigator

Project Period (FY)

Research Category

Research Institution

T細胞機能の酸化還元的制御に関わるアミノ酸トランスポーターの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New roprorective roles of amino acid transporrers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular cloning and functional expression of kidney-specific organic anionic drug transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グルタミン酸トランスポータファミリーの構造機能相関の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

T細胞機能の酸化還元的制御に関わるアミノ酸トランスポーターの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of glutamate transporters in the nervous system

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular identification of cystine / glutamate exchanger

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 薬学生の物理化学2021

Author(s)

Total Pages

UTSUNOMIYA-TATE Naoko 楯直子

楯直子タテナオコ

TATE Naoko 楯直子

宇都宮直子ウツノミヤナオコ