OHSUGI TAKEO 大杉剛生

… Alternative Names

OHSUGI Takeo 大杉剛生

大杉剛生オオスギタケオ

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Researcher Number	00211102
Other IDs
Affiliation (Current)	2025: 熊本大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 薬学部, 客員教授 2014 – 2021: 酪農学園大学, 獣医学群, 教授 2011 – 2013: 熊本大学, 生命資源研究・支援センター, 准教授 2007 – 2011: Kumamoto University, 生命資源研究支援センター, 准教授 2003 – 2005: 熊本大学, 生命資源研究・支援センター, 助教授 … More 2001 – 2002: 熊本大学, 動物資源開発研究センター, 助教授 2000: 順天堂大学, 医学部, 講師 1993: 久留米大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science / Basic Section 42020:Veterinary medical science-related / Basic Section 42040:Laboratory animal science-related / Laboratory animal science
Keywords	Principal Investigator HTLV-1 / mice / ATL / HTLV-I / animal model / 遺伝子改変マウス / 成人T細胞白血病 / Tax / SCID mice / Lck … More / transgenic mice / マウス / tax遺伝子 / Dok / 牛 / ＢＬＶ / DOk3遺伝子 / ＨＴＬＶ－１ / ＤＯＫ３遺伝子 / ＤＯＫ２遺伝子 / ＤＯＫ１遺伝子 / BLV / DOK3遺伝子 / DOK2遺伝子 / DOK1遺伝子 / 牛白血病 / ウシ / Dok3 / Dok2 / Dok1 / DOK１ / DOK3 / DOK2 / DOK1 / Dok-3 / Dok-2 / Dok-1 / tax / ATLL / 免疫不全 / 皮膚炎 / HAM/TSP / Dokファミリー / immunodeficiency / p53 / 疾患モデル / 関節炎 / in situ hybridization / 母子感染 / PCR / Animal model / Rat Less

ネコ免疫不全ウイルス（ＦＩＶ）感染症に対する新たな根本的治療法の開発Principal Investigator
- Principal Investigator
  
  大杉剛生
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kumamoto University
Bovine leukemia virus infection as a model of HTLV-1 -Dok genes function-Principal Investigator
- Principal Investigator
  
  Ohsugi Takeo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Rakuno Gakuen University
Expression analysis of DoK-1, Dok-2 and Dok-3 genes in mice expressing Tax, a human T-cell leukemia virus type 1 oncoproteinPrincipal Investigator
- Principal Investigator
  
  Ohsugi Takeo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Rakuno Gakuen University
Relationship between onset of T cell leukemia and immunodeficiency in young age in a mouse model of adult T-cell leukemiaPrincipal Investigator
- Principal Investigator
  
  OHSUGI Takeo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Rakuno Gakuen University
  Kumamoto University
Analysis of p53 function in HTLV-1 Tax transgenic micePrincipal Investigator
- Principal Investigator
  
  OHSUGI Takeo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Analysis of T cell leukemia/lymphoma in a human T-cell leukemia virus type I tax gene transgenic mouse modelPrincipal Investigator
- Principal Investigator
  
  OHSUGI Takeo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Development of model mice of adult T-cell leukemia for evaluation of new therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  OHSUGI Takeo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Development of HTLV-I Tax transgenic mice as an animal model for adult T-cell leukemia by using T cell specific gene promoter.Principal Investigator
- Principal Investigator
  
  OHSUGI Takeo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
  Juntendo University
成人T細胞白血病(ATL)母子感染モデルラットを用いたHTLV-I感染経路の解明Principal Investigator
- Principal Investigator
  
  大杉剛生
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kurume University

[Book] 九州で多発する白血病－成人T細胞白血病－『熊薬ものがたり　熊本大学薬学部の研究と教育』2014
- Author(s)
  大杉剛生
- Total Pages
  287
- Publisher
  熊本日日新聞社
- Data Source
  KAKENHI-PROJECT-24500493
[Book] 『モデル動物利用マニュアル』疾患モデルの作製と利用　がん2012
- Author(s)
  大杉剛生、山口一成
- Total Pages
  633
- Publisher
  ㈱エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-24500493
[Book] Human T-cell Leukemia Virus Type 1 (HTLV-1) and Antiviral Enzyme A POBEC3, Encyclopedia of Virology Research(Andrew P.Gatto and Benjamin S.Leon (eds))2012
- Author(s)
  T.Ohsugi, A.Koito
- Publisher
  NOVA Scientific publishers(印刷中)
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Human T-cell Leukemia Virus Type 1(HTLV-1) and Antiviral Enzyme APOBEC32012
- Author(s)
  T. Ohsugi, and A. Koito
- Publisher
  NOVA Scientific publishers
- Data Source
  KAKENHI-PROJECT-21500390
[Book] モデル動物利用マニュアル(中村卓郎編)(第2章がん、第5節造血系、遺伝子改変モデル、HTLV-1)2011
- Author(s)
  大杉剛生、山口一成
- Publisher
  株式会社エル・アイ・シー(印刷中)
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Molecular analysis of estrogen dependent breast cancer in animal model and cell lines. JSPS RONPAKU (Dissertation Ph.D.) program abstracts of dissertation for FY 20092011
- Author(s)
  M.Jerald Mahesh Kumar, Takeo Ohsugi
- Total Pages
  88
- Publisher
  Japan Society for the Promotion of Science
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Molecular analysis of estrogen dependent breast cancer in animal model and cell lines. JSPS RONPAKU(Dissertation Ph. D.) program abstracts of dissertation for FY2011
- Author(s)
  M. Jerald Mahesh Kumar and Takeo Ohsugi.
- Data Source
  KAKENHI-PROJECT-21500390
[Book] 九州で多発する白血病-成人T細胞白血病-『熊薬ものがたり熊本大学薬学部の研究と教育』2010
- Author(s)
  大杉剛生
- Publisher
  熊本日日新聞社
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Viral Genomes : Diversity, Properties and Parameters2009
- Author(s)
  Ohsugi, T., Koito, A.
- Total Pages
  267
- Publisher
  NOVA Scientific publishers
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Human T-cell Leukemia Virus Type 1(HTLV-1) and Antiviral Enzyme APOBEC3, Viral Genomes : Diversity, Properties and Parameters, Zhi Feng and Ming Long(eds)2009
- Author(s)
  Ohsugi, T. and Koito, A.
- Publisher
  NOVA Scientific publishers
- Data Source
  KAKENHI-PROJECT-21500390
[Book] ヒトT細胞白血病ウイルスI型HTLV-Iと疾患2007
- Author(s)
  大杉剛生
- Total Pages
  263
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19500363
[Book] ATL、HTLV-1の動物モデル。『HTLV-1と疾患』(渡邊俊樹、上平憲、山口一成編)2007
- Author(s)
  大杉剛生
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19500363
[Book] 第2章がん、第5節造血系、遺伝子改変モデル、HTLV-1『モデル動物利用マニュアル』(中村卓郎編)
- Author(s)
  大杉剛生、山口一成
- Publisher
  株式会社エル・アイ・シー(末定)(印刷中)
- Data Source
  KAKENHI-PROJECT-21500390
[Book] 第2章がん、第5節造血系、遺伝子改変モデル
- Author(s)
  大杉剛生、山口一成
- Publisher
  (株)エル・アイ・シー(印刷中)
- Data Source
  KAKENHI-PROJECT-21500390
[Book] Human T-cell Leukemia Virus Type 1 (HTLV-1) and Antiviral Enzyme APOBEC3. ViralGenomes : Diversity, Properties and Parameters, Zhi Feng and Ming Long (eds)
- Author(s)
  Ohsugi, T. and Koito, A.
- Publisher
  NOVA Scientific publishers(in press)
- Data Source
  KAKENHI-PROJECT-19500363
[Book] Viral Genomes ; Human T-cell Leukemia Virus Type l(HTLV-l)and Antiviral Enzyme AP0BEC3
- Author(s)
  Ohsugi, T.
- Publisher
  NOVA Scientific publishers(in press)
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Elucidation of the mechanism of host NMD suppression by HTLV-1 Rex: Dissection of Rex to identify the NMD inhibitory domain2022
- Author(s)
  Nakano, K., Karasawa N., Hashizume M., Tanaka, Y, Ohsugi, T., Uchimaru. K. and Watanabe, T.
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 2 Pages: 344-344
- DOI
  10.3390/v14020344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K07573, KAKENHI-PROJECT-20KK0181
[Journal Article] SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma2022
- Author(s)
  Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu-Ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin-Ichiro Honda
- Journal Title
  
  FEBS J
  
  Volume: in press Issue: 12 Pages: 1-12
- DOI
  10.1111/febs.16353
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-22K08491
[Journal Article] Cell death induced by dorsomorphin in adult T-cell leukemia/lymphoma is AMPK-independent.2020
- Author(s)
  Aikawa A, Kozako T, Uchida Y, Yoshimitsu M, Ishitsuka K, Ohsugi T, Honda SI.
- Journal Title
  
  FEBS J.
  
  Volume: n/a Issue: 18 Pages: 4005-4015
- DOI
  10.1111/febs.15239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18K06036
[Journal Article] Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains2019
- Author(s)
  TSUKAMOTO Yoriko、YAMADA Norihide、MIYOSHI Kenjiro、YAMASHITA Kazuto、OHSUGI Takeo
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 81 Issue: 6 Pages: 937-945
- DOI
  10.1292/jvms.18-0712
- NAID
  130007668554
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036
[Journal Article] A novel mouse model of adult T‐cell leukemia cell invasion into the spinal cord.2019
- Author(s)
  Ohsugi, T., Tanaka, S., Iwasaki, K., Nagano, Y., Kozako, T., Matsuda, K., Hirose, T. and Takehana, K.
- Journal Title
  
  Animal Model Exp. Med.
  
  Volume: 2 Issue: 1 Pages: 64-67
- DOI
  10.1002/ame2.12053
- NAID
  120006901053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K08851
[Journal Article] Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas2019
- Author(s)
  Yamagishi M., Hori M., Fujikawa D., Ohsugi T., Honma D., Adachi N., Katano H., Hishima T., Kobayashi S., Nakano K., Nakashima M., Iwanaga M., Utsunomiya A., Tanaka Y., Okada S., Tsukasaki K., Tobinai K., Araki K., Watanabe T., Uchimaru K.
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 8 Pages: 2321-2337
- DOI
  10.1016/j.celrep.2019.10.083
- NAID
  120006901051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-16H06277
[Journal Article] New SIRT2 inhibitors: Histidine-based bleomycin spin-off2019
- Author(s)
  Ali Taha F.S.、Ciftci Halil I.、Radwan Mohamed O.、Koga Ryoko、Ohsugi Takeo、Okiyama Yoshio、Honma Teruki、Nakata Akiko、Ito Akihiro、Yoshida Minoru、Fujita Mikako、Otsuka Masami
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 9 Pages: 1767-1775
- DOI
  10.1016/j.bmc.2019.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08861, KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-17H03999
[Journal Article] High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor2019
- Author(s)
  Kozako Tomohiro、Aikawa Akiyoshi、Ohsugi Takeo、Uchida Yu-ichiro、Kato Naho、Sato Keisuke、Ishitsuka Kenji、Yoshimitsu Makoto、Honda Shin-ichiro
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 865 Pages: 172738-172738
- DOI
  10.1016/j.ejphar.2019.172738
- NAID
  120006901050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K08851
[Journal Article] Anti-cancer activity of the cell membrane-permeable phytic acid prodrug2019
- Author(s)
  Masunaga Takuya、Murao Naoki、Tateishi Hiroshi、Koga Ryoko、Ohsugi Takeo、Otsuka Masami、Fujita Mikako
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 92 Pages: 103240-103240
- DOI
  10.1016/j.bioorg.2019.103240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-17K08861, KAKENHI-PROJECT-17H03999
[Journal Article] Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.2018
- Author(s)
  Kozako, T., Mellini, P., Ohsugi, T., Aikawa, A., Uchida, Y. I., Honda, S. I., Suzuki, T.
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 791-791
- DOI
  10.1186/s12885-018-4710-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-16K09863
[Journal Article] Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice2017
- Author(s)
 Ohsugi, T.
- Journal Title
 
 Journal of Veterinary Medical Science
 
 Volume: 79 Issue: 5 Pages: 935-938
- DOI
 10.1292/jvms.17-0034
- NAID
 130005665593
- ISSN
 0916-7250, 1347-7439
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K06806
[Journal Article] Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.2016
- Author(s)
  Ohsugi, T., Wakamiya, M., Morikawa, S. and Fujita, M.
- Journal Title
  
  Acta Virologica
  
  Volume: 60 Issue: 02 Pages: 211-213
- DOI
  10.4149/av_2016_02_211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06806
[Journal Article] Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells2016
- Author(s)
  Ohsugi, T., Wakamiya, M., Morikawa, S. and Fujita, M.
- Journal Title
  
  Acta Virologica
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06806
[Journal Article] Evaluation of a combination of alfaxalone with medetomidine and butorphanol for inducing surgical anesthesia in laboratory mice2016
- Author(s)
  Higuchi, S., Yamada, R., Hashimoto, A., Miyoshi, Yamashita, K. and Ohsugi, T.
- Journal Title
  
  Japanese Journal of Veterinary Research
  
  Volume: -
- NAID
  120005763158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06806
[Journal Article] Evaluation of a combination of alfaxalone with medetomidine and butorphanol for inducing surgical anesthesia in laboratory mice2016
- Author(s)
  Higuchi, S., Yamada, R., Hashimoto, A., Miyoshi, K.,Yamashita, K. and Ohsugi, T.
- Journal Title
  
  Japanese Journal of Veterinary Research
  
  Volume: 64 Issue: 2 Pages: 131-139
- DOI
  10.14943/jjvr.64.2.131
- NAID
  120005763158
- ISSN
  0047-1917
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06806
[Journal Article] 成人Ｔ細胞白血病(ATL)治療の最前線－抗CCR4抗体の憂鬱－2015
- Author(s)
  大杉剛生
- Journal Title
  
  日本ウイルス学会北海道支部報
  
  Volume: 46 Pages: 2-6
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] 成人Ｔ細胞白血病(ATL)治療の最前線－抗CCR4抗体の憂鬱－2015
- Author(s)
  大杉剛生
- Journal Title
  
  日本ウイルス学会北海道支部報
  
  Volume: 46 Pages: 2-6
- Data Source
  KAKENHI-PROJECT-15K06806
[Journal Article] HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)-like disease and toxic epidermal necrolysis (TEN)-like disease in HTLV-1 Tax transgenic mice.2014
- Author(s)
  Ohsugi T, Wakamiya M, Morikawa S, Matsuura K, Kumasaka T, Yamaguchi K
- Journal Title
  
  Retrovirology
  
  Volume: 11 Issue: S1
- DOI
  10.1186/1742-4690-11-s1-p40
- NAID
  120005762017
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice.2014
- Author(s)
  Ohsugi T.
- Journal Title
  
  Curr. Trends Immunol
  
  Volume: 15 Pages: 43-46
- NAID
  120005762011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] A transgenic mouse model of human T-cell leukemia virus type I (HTLV-1)-associated diseases2013
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 4 Pages: 49-49
- DOI
  10.3389/fmicb.2013.00049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein.2013
- Author(s)
  Ohsugi, T., Ishida, T., Shimasaki, T., Okada, S. and Umezawa, K.
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Issue: 9 Pages: 2129-2136
- DOI
  10.1093/carcin/bgt144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication.2013
- Author(s)
  Nakano, K., Ando, T., Yamagishi, M., Yokoyama, K., Ishida, T., Ohsugi, T., Tanaka, Y., Brighty, D. W. and Watanabe, T.
- Journal Title
  
  Microbes and Infection
  
  Volume: 15 Issue: 6-7 Pages: 491-505
- DOI
  10.1016/j.micinf.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493, KAKENHI-PROJECT-24501304, KAKENHI-PROJECT-221S0001
[Journal Article] Invasion of Histiocytic Sarcoma into the Spinal Cord of HTLV-1 Tax Transgenic Mice with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis-Like Disease.2013
- Author(s)
  Ohsugi, T., Wakamiya, M., Morikawa, S., Matsuura, K., Kumar, J. M., Kumasaka, T. and Yamaguchi, K.
- Journal Title
  
  Oncology Research
  
  Volume: 20 Issue: 9 Pages: 403-410
- DOI
  10.3727/096504013x13657689383058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice.2013
- Author(s)
  Ohsugi, T., Matsuura, K., Kawabe, S., Nakamura, N., Kumar, J. M., Wakamiya, M., Morikawa, S. and Urano, T.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 4 Pages: 12-12
- DOI
  10.3389/fmicb.2013.00012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] 乳がんの抗エストロゲン療法とマウスモデル2012
- Author(s)
  ジェラルド・マヘッシュ・クマール、大杉剛生
- Journal Title
  
  九州実験動物雑誌
  
  Volume: 28 Pages: 35-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] Tamoxifen resistant, ER positive MAC 51 cell line with high metastatic potential developed from spontaneous breast cancer mouse model.2012
- Author(s)
  Kumar, J. M., Shivakumar, P., Nagarajan, P., Subramaniyam, T., Jose, J., Ganapathy, H. S. and Ohsugi, T.
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 350 Pages: 347-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500493
[Journal Article] Altered CD4^+/CD8^+ T-cell ratio in splenocytes of human T-cell leukemia virus type I Tax transgenic mice with inflammatory arthropathy2011
- Author(s)
  Ohsugi, T., Kumasaka, T.
- Journal Title
  
  Retrovirology
  
  Volume: 8(Suppl 1) Issue: S1
- DOI
  10.1186/1742-4690-8-s1-a2
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Altered CD4^+/CD8^+T-cell ratio in splenocytes of human T-cell leukemia virus type I Tax transgenic mice with inflammatory arthropathy2011
- Author(s)
  Ohsugi, T. and Kumasaka, T.
- Journal Title
  
  Retrovirology
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type 1 Tax transgenic mice2011
- Author(s)
  Ohsugi, T., Kumasaka, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 4 Pages: e18518-e18518
- DOI
  10.1371/journal.pone.0018518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.2011
- Author(s)
  Ohsugi, T., Kumasaka, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type 1 Tax transgenic mice2011
- Author(s)
  Ohsugi, T. and Kumasaka, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway2009
- Author(s)
  Takahashi-Makise N., Suzu, S., Hiyoshi, M., Ohsugi, T., Katano, H., Umezawa, K. and Okada, S.
- Journal Title
  
  Int J Cancer
  
  Volume: 125 Pages: 1464-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Increased production of viral proteins by a 3'-LTR-deleted infectious clone of human T-cell leukemia virus type 12009
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Virology Journal
  
  Volume: 6 Pages: 229-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Increased production of viral proteins by a 3'-LTR-deleted infectious clone of human T-cell leukemia virus type 12009
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Virology Journal 6
  
  Pages: 229-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Development of Mouse Models of Adult T-Cell Leukemia for Evaluation of New Anticancer Agents2009
- Author(s)
  Ohsugi, T. and M. Jerald Mahesh Kumar
- Journal Title
  
  Current Topics in Biochemical Research
  
  Volume: 11 Pages: 57-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway2009
- Author(s)
  Takahashi-Makise N., Suzu, S., Hiyoshi, M., Ohsugi, T., Katano, H., Umezawa, K., Okada, S.
- Journal Title
  
  Int J Cancer 125
  
  Pages: 1464-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Journal Article] Current topics in prevention of Human T-cell leukemia virus type l(HTLV-I)infection : NF-kB inhibitors and APOBEC32008
- Author(s)
  Ohsugi, T.
- Journal Title
  
  International Reviews of Immunology 27
  
  Pages: 177-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] The anti-retroviral potency of APOBEC1 deaminase from small animal species2008
- Author(s)
  Ikeda, T., Ohsugi, T., Kimura, T. Matsushita, S., Maeda, Y., Harada, S., and Koito, A.
- Journal Title
  
  Nucleic Acids Res 36
  
  Pages: 6859-6871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Invited review : Current topics in prevention of Human T-cell leukemia virus type I (HTLV-I) infection : NF-KB inhibitors and APOBEC32008
- Author(s)
  Ohsugi, T. and Koito, A.
- Journal Title
  
  International Reviews of Immunology 27
  
  Pages: 177-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Current topics in prevention of Human T-Cell Leukemia Virus Type I Infection: NF-κB inhitors and APOBEC32008
- Author(s)
  Ohsugi, T.
- Journal Title
  
  International Reviews of Immunology 27
  
  Pages: 1-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC32007
- Author(s)
  Ohsugi, T.
- Journal Title
  
  J. Virol, Methods 139
  
  Pages: 93-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines2007
- Author(s)
  Ohsugi, T., Kumasaka, T., Okada, S., Ishida, T., Yamaguchi, K., Horie, R., Watanabe, T. and Umezawa, K.
- Journal Title
  
  Cancer letters 257
  
  Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Development T cell leukemia/lymphoma and arthropathy in transgenic mice carrying human T cell leukemia virus type I tax gene2007
- Author(s)
  Ohsugi, T., Kumasaka, T., Okada, S. andUrano, T.
- Journal Title
  
  AIDS Res. Hum. Retroviruses 23
  
  Pages: 583-583
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Development T cell leukemia/lymphoma and arthropathy in transgenic mice carrying human T cell leukemia virus type Itax gene2007
- Author(s)
  Ohsugi, T.
- Journal Title
  
  AIDS Res. Hum. Retroviruses 23
  
  Pages: 583-583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult Tcell leukemia-derived cell lines2007
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Cancer letters 257
  
  Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells2007
- Author(s)
  Ohsugi, T., Kumasaka, T., Okada, S. and Urano, T.
- Journal Title
  
  Nature Medicine 13
  
  Pages: 527-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC32007
- Author(s)
  Ohsugi, T. and Koito, A.
- Journal Title
  
  J. Virol. Methods 139
  
  Pages: 93-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells2007
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Nature Medicine 13
  
  Pages: 527-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500363
[Journal Article] In vitro and in vivo antitumor activity of the NF-κB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.2006
- Author(s)
  Ohsugi T et al.
- Journal Title
  
  Leukemia Res. 30
  
  Pages: 90-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Activation of a cryptic splice site in the tax gene of HTLV-I by a single nucleotide change.2006
- Author(s)
  Ohsugi, T.
- Journal Title
  
  Biochimie 88
  
  Pages: 147-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] In vitro and in vivo antitumor activity of the NF-κB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.2006
- Author(s)
  Ohsugi, T. et al.
- Journal Title
  
  Leukemia Res 30
  
  Pages: 90-97
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] In vitro and in vivo antitumor activity of the NF-κB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line,HUT-102.2006
- Author(s)
  Ohsugi, T. et al.
- Journal Title
  
  Leukemia Res 30
  
  Pages: 90-97
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] In vivo antitumor activity of the NF-kB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia.2005
- Author(s)
  Ohsugi T et al.
- Journal Title
  
  Carcinogenesis 26
  
  Pages: 1382-1388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] In vivo antitumor activity of the NF-kB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia.2005
- Author(s)
  Ohsugi, T. et al.
- Journal Title
  
  Carcinogenesis 26
  
  Pages: 1382-1388
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-kB, as a strategy for chemoprevention and therapy of adult T cell2005
- Author(s)
  Watanabe, M., Ohsugi, T., Shoda, M.et al.
- Journal Title
  
  Blood 106
  
  Pages: 2462-2471
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] In vivo antitumor activity of the NF-kB inhibitor dehydroxymethyl epoxyquinomicin in a mouse model of adult T-cell leukemia.2005
- Author(s)
  Ohsugi, T. et al.
- Journal Title
  
  Carcinogenesis 26
  
  Pages: 1382-1388
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ,a potent and selective inhibitor of NF-kB,as a strategy for chemoprevention and therapy of adult T cell2005
- Author(s)
  Watanabe, M., Ohsugi, T., Shoda, M., et al.
- Journal Title
  
  Blood 106
  
  Pages: 2462-2471
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-kB, as a strategy for chemoprevention and therapy of adult T cell leukemia.2005
- Author(s)
  Watanabe M, Ohsugi T, Shoda M et al.
- Journal Title
  
  Blood 106
  
  Pages: 2462-2471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Construction of a full-length human T cell leukemia virus type I(HTLV-I) genome from MT-2 cells containing multiple defective proviruses using overlapping polymerase chain reaction2004
- Author(s)
  Ohsugi, T., Kumasaka, T., Urano, T.
- Journal Title
  
  Anal.Biochem. 329
  
  Pages: 281-288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Rapid tumor death model for evaluation of new therapeutic agents for Adult T-cell Leukemia2004
- Author(s)
  Ohsugi, T. et al.
- Journal Title
  
  Lab.Invest 84
  
  Pages: 263-266
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Construction of a full-length human T cell leukemia virus type I (HTLV-I) genome from MT-2 cells containing multiple defective proviruses using overlapping polymerase chain reaction.2004
- Author(s)
  Ohsugi T et al.
- Journal Title
  
  Anal.Biochem. 329
  
  Pages: 281-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Construction of a full-length human T cell leukemia virus type I (HTLV-I) genome from MT-2 cells containing multiple defective proviruses using overlapping polymerase chain reaction.2004
- Author(s)
  Ohsugi, T., et al.
- Journal Title
  
  Analytical Biochemistry 329
  
  Pages: 281-288
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Rapid tumor death model for evaluation of new therapeutic agents for Adult T-cell Leukemia.2004
- Author(s)
  Ohsugi T et al.
- Journal Title
  
  Lab.Invest. 84
  
  Pages: 263-266
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Rapid tumor death model for evaluation of new therapeutic agents for Adult T-cell Leukemia.2004
- Author(s)
  Ohsugi, T., et al.
- Journal Title
  
  Laboratory Investigation 84
  
  Pages: 263-266
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Effect of age on production of animal model for adult T-cell leukemia in severe combined immunodeficiency mice.2003
- Author(s)
  Ohsugi T.et al.
- Journal Title
  
  Kyusyu J.Exp.Anim.(in Japanese) 20
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] 重症複合免疫不全(SCID)マウスを用いた成人T細胞白血病(ATL)モデル作製における加齢の影響2003
- Author(s)
  大杉剛生ら
- Journal Title
  
  九州実験動物雑誌 19
  
  Pages: 25-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500300
[Journal Article] Development of Mouse Models of Adult T-Cell Leukemia for Evaluation of New Anticancer Agents
- Author(s)
  Ohsugi, T., Kumar, J.M.
- Journal Title
  
  Current Topics in Biomedical Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] 健常ウシ末梢血単核球および牛白血病におけるDOK1/2/3遺伝子の発現2021
- Author(s)
  3.吉永佳乃、島﨑ルシア、白崎有莉、橋本祐樹、岡崎克則、川本　哲、菊　佳男、大塚浩通、大杉剛生：
- Organizer
  第164回日本獣医学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] 成人T細胞白血病（ATL）細胞株に対するSIRT1活性化剤SRT1720の腫瘍抑制効果2021
- Author(s)
  2.大杉剛生、小迫知弘、飯沼海仁、猪狩陽希、橋本祐樹、加藤奈歩、佐藤　陽菜、相川　晃慶、本田　伸一郎
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] 成人T細胞白血病におけるSRT1720の抗腫瘍効果2020
- Author(s)
  1.小迫知弘, 加藤奈歩, 大杉剛生, 相川晃慶, 佐藤陽菜, 本田伸一郎
- Organizer
  日本分子生物学会オンライン開催
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] AICARを用いた新規成人T細胞白血病治療法の検討2019
- Author(s)
  相川晃慶、小迫知弘、吉満誠、大杉剛生、本田　伸一郎
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] AICARを用いた新規成人T細胞白血病治療法の検討2019
- Author(s)
  相川晃慶、小迫知弘、吉満誠、大杉剛生、本田　伸一郎
- Organizer
  日本薬学会第139年会（千葉）
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] High NAMPT expression and anti-tumor activity of NAMPT inhibitor in adult T-cell leukemia/lymphoma.2019
- Author(s)
  Tomohiro Kozako, Takeo Ohsugi, Yu-ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Naho Kato, Keisuke Sato, Akiyoshi Aikawa, and Shin-ichiro Honda
- Organizer
  ESMO 2019 Congress (Barcelona, Spain)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] NAMPT阻害剤による成人T細胞白血病細胞における抗腫瘍効果の検討2019
- Author(s)
  加藤奈歩、小迫知弘、大杉剛生、内田友一朗、吉満誠、石塚賢治、佐藤啓介、相川晃慶、本田伸一郎
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] アルファキサロンを用いた新規麻酔薬に対するアチパメゾールの拮抗効果2019
- Author(s)
  松山真也、堀尾春佳、三好健二郎、山下和人、大杉剛生
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] AICARによるHTLV-1感染細胞株の細胞死誘導機序についての検討2019
- Author(s)
  山崎七恵、相川晃慶、小迫知弘、　大杉剛生、本田伸一郎
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] Overexpression of NAMPT in adult T-cell leukemia/lymphoma patients and antitumor activity of a NAMPT inhibitor in vivo.2018
- Author(s)
  Tomohiro Kozako, Takeo Ohsugi, Makoto Yoshimitsu, Yu-ichiro Uchida, Kenji Ishitsuka, Naho Kato, Akiyoshi Aikawa, and Shin-ichiro Honda
- Organizer
  ESMO 2018 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] アルファキサロンを用いた新規混合麻酔薬の各マウス系統での評価2018
- Author(s)
  塚本依子、山田典英、三好健二郎、山下和人、大杉剛生
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] アルファキサロンを用いた新規混合麻酔薬の各マウス系統での評価2018
- Author(s)
  塚本依子、山田典英、三好健二郎、山下和人、大杉剛生
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] 成人T細胞白血病細胞におけるNAMPT阻害剤による細胞死の検討2018
- Author(s)
  加藤奈歩、小迫知弘、大杉剛生、吉満誠、内田友一朗、石塚賢、相川晃慶、本田伸一郎
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06036
[Presentation] Tamoxifen inhibits the infiltration of human T-cell leukemia virus type 1-infected cells into organs in a mouse model of adult T-cell leukemia.2017
- Author(s)
  Tanaka, Y., Kozuka, T., Yamagishi, M., Hirose, T., Nagano, Y., Nishii, R., Kitamura, H., Takehana, K., Watanabe, T. and Ohsugi, T.
- Organizer
  18th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  ホテルグランドアーク半蔵門（東京都）
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] タモキシフェンによるHTLV-1感染細胞増殖抑制2017
- Author(s)
  大杉剛生、長野佑祐、田中　雄三、小塚友喜、西井里衣、山岸　誠、渡邉俊樹
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] EZH1/2阻害による悪性リンパ腫のエピゲノム制御2017
- Author(s)
  山岸誠、堀真琴、藤川大、本間大輔、安達宣明、大杉剛生、中野和民、中島誠、小林誠一郎、岩永正子、宇都宮與、岡田誠治、塚崎邦弘、飛内賢正、荒木一司、渡邉俊樹、内丸薫
- Organizer
  第79回日本血液学学術集会
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] 成人T細胞白血病（ATL）モデルマウスにおけるタモキシフェンの効果2017
- Author(s)
  長野佑祐、西井里衣、小塚友樹、田中雄三、大杉剛生
- Organizer
  第14回北海道実験動物研究会・学術集会
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] アルファキサロン、メデトミジン、ブトルファノール三種混合麻酔薬の実験用マウスにおける性差および系統差2017
- Author(s)
  山田典英、塚本依子、山田　陸、三好健二郎、山下和人、大杉剛生
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] Development and molecular analysis of synthetic lethality by targeting EZH1/2 in ATL and HTLV-1-infected cells.2017
- Author(s)
  Yamagishi, M., Hori, M., Fujiwara, D., Honma, D., Adachi, N., Ohsugi, T., Nakano, K., Nakashima, M., Kobayashi, S., Iwanaga, M., Utsunomiya, A., Tanaka, Y., Okada, S., Tsukasaki, K., Toninai, K., Araki, K., Watanabe, T. and Uchimaru, K.
- Organizer
  18th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  ホテルグランドアーク半蔵門（東京都）
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] アルファキサロン、メデトミジン、ブトルファノール三種混合麻酔薬のマウスへの応用2016
- Author(s)
  山田　陸、樋口翔太、橋本麻美、三好健二郎、山下和人、大杉剛生
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県・川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] 成人T細胞白血病のモデルマウスの進展2015
- Author(s)
  大杉剛生
- Organizer
  第12回北海道実験動物研究会
- Place of Presentation
  北海道大学医学部講義棟(北海道・札幌市）
- Year and Date
  2015-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K06806
[Presentation] 米国からの実験用ウズラ輸入の経験2013
- Author(s)
  中村直子、川辺正等美、古島志伸、坂本　亘、佐藤有紀、大杉剛生、浦野　徹
- Organizer
  第31回九州実験動物研究会総会
- Place of Presentation
  八千代座（熊本県山鹿市山鹿）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP)-like disease and toxic epidermal necrolysis (TEN)-like disease in HTLV-1 Tax transgenic mice2013
- Author(s)
  Takeo Ohsugi, Makoto Wakamiya, Saki Morikawa, Kumi Matsuura, Toshio Kumasaka, Kazunari Yamaguchi
- Organizer
  16th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] アイソレーターを用いた検疫体制2013
- Author(s)
  坂本　亘、中村直子、川辺正等美、大杉剛生、浦野　徹
- Organizer
  第31回九州実験動物研究会総会
- Place of Presentation
  八千代座（熊本県山鹿市山鹿）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)- like disease and toxic epidermal necrolysis (TEN)-like disease in HTLV-1 Tax transgenic mice.2013
- Author(s)
  Takeo Ohsugi, Makoto Wakamiya, Saki Morikawa, Kumi Matsuura, Toshio Kumasaka, Kazunari Yamaguchi
- Organizer
  16th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Holiday Inn Montreal-Midtown (Midtown Montreal, Canada)
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] Helicobacter hepaticusの摘発とその後の対応による統御2013
- Author(s)
  川辺正等美、松浦公美、中村直子、大杉剛生、浦野　徹
- Organizer
  第31回九州実験動物研究会総会
- Place of Presentation
  八千代座（熊本県山鹿市山鹿）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] Taxトランスジェニックマウスに観察されたHAM様マウスと中毒性皮膚壊死症（TEN）様疾患2013
- Author(s)
  大杉剛生、若宮　誠、森川沙樹、熊坂利夫、山口一成
- Organizer
  第6回HTLV-1研究会・シンポジウム
- Place of Presentation
  東京大学医科学研究所（東京都港区）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] HTLV-1感染細胞およびマウスモデル由来脾臓細胞における新規合成DTCM-Gのp53活性化作用2013
- Author(s)
  大杉剛生、若宮　誠、森川沙樹、梅澤一夫
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸市中央区）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] HTLV-1 Taxによるp53不活化機構2012
- Author(s)
  大杉剛生、島崎達也、石田尚臣、岡田誠治、梅澤一夫
- Organizer
  第5回HTLV-1研究会
- Place of Presentation
  東京大学医科学研究所（東京都）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] 実験用フェレットの飼育管理経験2012
- Author(s)
  坂本　亘、古島志伸、野口和浩、崎尾　昇、小糸　厚、大杉剛生、浦野　徹
- Organizer
  日本実験動物科学・技術　九州2012
- Place of Presentation
  別府国際コンベンションセンター（大分市）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] 動物実験施設における黄色ブドウ球菌の分離と薬剤耐性2012
- Author(s)
  中村直子、伊藤輝代、松浦公美、川辺正等美、若宮　誠、大杉剛生、浦野　徹
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学（盛岡市）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] HTLV-1 Tax-Tgマウスにおけるp53およびNF-κBの動態2012
- Author(s)
  大杉剛生、石田尚臣、島崎達也、岡田誠治、梅澤一夫
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  グランキューブ大阪(大阪市）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] 熊本大学動物資源開発研究施設本館の空調機改修工事および新規マウスラックの導入2012
- Author(s)
  崎尾　昇, 中村直子, 坂本　亘、古島志伸、河津明友、上羽　進、大杉剛生, 浦野　徹
- Organizer
  日本実験動物科学・技術　九州2012
- Place of Presentation
  別府国際コンベンションセンター（大分市）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] ウズラの飼育経験2012
- Author(s)
  古島志伸、永利　圭、崎尾　昇、中村直子、大杉剛生, 浦野　徹、佐藤有紀
- Organizer
  日本実験動物科学・技術　九州2012
- Place of Presentation
  別府国際コンベンションセンター（大分市）
- Data Source
  KAKENHI-PROJECT-24500493
[Presentation] Altered CD4+/CD8+ T-cell ratio in splenocytes of human T-cell leukemia virus type 1 Tax transgenic mice with inflammatory arthropathy2011
- Author(s)
  Takeo Ohsugi, Toshio Kumasaka
- Organizer
  15th International Conference on Human Retrovirology
- Place of Presentation
  Pieter De Somer Aula (Leuven, Belgium)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] Tax遺伝子導入マウスにみられる多様な疾患2011
- Author(s)
  大杉剛生、島崎達也、岡田誠治、石田尚臣、熊坂利夫
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東京大学(東京)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] Tax遺伝子導入マウスにみられる多様な疾患2011
- Author(s)
  大杉剛生、島崎達也、岡田誠治、石田尚臣、熊坂利夫
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東大医科研(東京都)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] Altered CD4+/CD8+T-cell ratio in splenocytes of human T-cell leukemia virus type 1 Tax transgenic mice with inflammatory arthropathy2011
- Author(s)
  Takeo Ohsugi, Toshio Kumasaka
- Organizer
  15th International Conference on Human Retrovirology : HTLV and Related Retroviruses
- Place of Presentation
  Pieter De Somer Aula (Leuven) Belgium
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] ヒトT細胞白血病ウイルス(HTLV-1)taxトランスジェニックマウスにおける関節炎の解析.2010
- Author(s)
  大杉剛生、熊坂利夫
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] エストロゲン依存性乳がんマウスモデルの樹立2010
- Author(s)
  Jerald Mahesh Kumar、大杉剛生
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都テルサ(京都)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] HTLV-1 tax遺伝子導入マウスにおける関節炎とHAM/TSPとの類似性2010
- Author(s)
  大杉剛生、島崎達也、熊坂利夫
- Organizer
  第3回HTLV-1研究会・合同班会議
- Place of Presentation
  東大医科研(東京都)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] ヒトT細胞白血病ウイルス(HTLV-1) taxトランスジェニックマウスにおける関節炎の解析2010
- Author(s)
  大杉剛生、熊坂利夫
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  あわぎんホール(徳島)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] HTLV-1 tax遺伝子導入マウスにおける関節炎とHAM/TSPとの類似性2010
- Author(s)
  大杉剛生、島崎也、熊坂夫
- Organizer
  第3回HTLV-1研究会・合同班会議
- Place of Presentation
  東京大学(東京)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] Molecular analysis of estrogen dependent breast cancer in animal model and cell line2009
- Author(s)
  Jerald M. Kumar, Masami Otsuka, Ken-ichi Yamamura, Yoichiro Isohama, and Takeo Ohsugi
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Kyusyu University(Fukuoka)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] Molecular Analysis of Estrogen Dependent Breast Cancer in Animal Model and Cell Line2009
- Author(s)
  Jerald M.Kumar, Masami Otsuka, Ken-ichi Yamamura, Yoichiro Isohama, Takeo Ohsugi
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Fukuoka, Centennial Hall Kyushu University School of Medicine, Japan
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] HTLV-1 Taxによるp53機能抑制機序の解析2009
- Author(s)
  大杉剛生、岡田誠治、熊坂利夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] HTLV-1 Taxによるp53機能抑制機序の解析2009
- Author(s)
  大杉剛生, 岡田誠治, 熊坂利夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京・都市センターホテル
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] ヒトT細胞白血病ウイルス1型(HTLV-1)感染症モデルマウスのp53機能解析2009
- Author(s)
  大杉剛生、鈴木操、島崎達也、岡田誠治、浦野徹、熊坂利夫
- Organizer
  第56回日本実験動物学会総会
- Place of Presentation
  大宮ソニックホール(大宮)
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] ヒトT細胞白血病ウイルス1型(HTLV-1)感染症モデルマウスのp53機能解析2009
- Author(s)
  大杉剛生, 鈴木操, 島崎達也, 岡田誠治, 浦野徹, 熊坂利夫
- Organizer
  第56回日本実験動物学会総会
- Place of Presentation
  埼玉・大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21500390
[Presentation] ヒトT細胞白血病ウイルスl型(HTLV-l)tax遺伝子導入マウスにみられた成熟T細胞白血病・リンパ腫の解析2008
- Author(s)
  大杉剛生
- Organizer
  日本実験動物科学技術2008
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] Transgenic Mice Expressing the HTLV-1 Tax Gene Develop Two Distinct Diseases : Leukemia and Arthropathy2008
- Author(s)
  Takeo Ohsugi
- Organizer
  99th AACR Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] ヒトT細胞白血病ウイルスl型(HTLV-l)tax遺伝子導入マウスにおけるp53機能の解析2008
- Author(s)
  大杉剛生
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] Transgenic Mice Expressing the HTLV-l Tax Gene Develop Two Distinct Diseases : Leukemia and Arthropathy2008
- Author(s)
  Takeo Ohsugi
- Organizer
  99th AACR Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] ヒトT細胞白血病ウイルスI型(HTLV-I)tax遺伝子導入マウスにみられた成熟T細胞白血病・リンパ腫の解析2008
- Author(s)
  大杉剛生
- Organizer
  日本実験動物科学技術
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] ヒトT細胞白血病ウイルスI型(HTLV-I)tax遺伝子導入マウスにおけるp53機能の解析2008
- Author(s)
  大杉剛生
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] Development T cell leukemia/lymphoma and arthropathy in transgenic mice carrying human T cell leukemia virus type Itax gene2007
- Author(s)
  Ohsugi, T.
- Organizer
  13th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Hakone,Japan
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] Development T cell leukemia/lymphoma and arthropathy in transgenic mice carrying human T cell leukemia virus type I tax gene2007
- Author(s)
  Takeo Ohsugi
- Organizer
  13th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Hakone, Japan
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] ヒトT細胞白血病ウイルスI型(HTLV-I)Tax遺伝子導入マウスの病態解析2007
- Author(s)
  大杉剛生
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19500363
[Presentation] HTLV-1感染細胞株およびHTLV-1 TaxトランスジェニックマウスにおけるDok-1,2および3の発現
- Author(s)
  大杉剛生、若宮　誠、森川沙樹、中村直子、川辺正等美、藤田美歌子
- Organizer
  第６２回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜(横浜市西区）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24500493

1. WATANABE Toshiki (30182934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. URANO Toru (90101899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 羅智靖 (60230851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久原孝俊 (70134616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口一成 (20128325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOZAKO Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 大塚雅巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤田美歌子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHSUGI TAKEO 大杉 剛生

OHSUGI Takeo 大杉 剛生

大杉 剛生 オオスギ タケオ

Research Projects

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Co-Researchers

ネコ免疫不全ウイルス（ＦＩＶ）感染症に対する新たな根本的治療法の開発Principal Investigator

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Bovine leukemia virus infection as a model of HTLV-1 -Dok genes function-Principal Investigator

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Expression analysis of DoK-1, Dok-2 and Dok-3 genes in mice expressing Tax, a human T-cell leukemia virus type 1 oncoproteinPrincipal Investigator

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Relationship between onset of T cell leukemia and immunodeficiency in young age in a mouse model of adult T-cell leukemiaPrincipal Investigator

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Analysis of p53 function in HTLV-1 Tax transgenic micePrincipal Investigator

Principal Investigator

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Analysis of T cell leukemia/lymphoma in a human T-cell leukemia virus type I tax gene transgenic mouse modelPrincipal Investigator

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Development of model mice of adult T-cell leukemia for evaluation of new therapeutic agentsPrincipal Investigator

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Development of HTLV-I Tax transgenic mice as an animal model for adult T-cell leukemia by using T cell specific gene promoter.Principal Investigator

Principal Investigator

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成人T細胞白血病(ATL)母子感染モデルラットを用いたHTLV-I感染経路の解明Principal Investigator

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Research Institution

[Book] 九州で多発する白血病－成人T細胞白血病－ 『熊薬ものがたり 熊本大学薬学部の研究と教育』2014

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[Book] 『モデル動物利用マニュアル』 疾患モデルの作製と利用 がん2012

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Total Pages

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Data Source

[Book] Human T-cell Leukemia Virus Type 1 (HTLV-1) and Antiviral Enzyme A POBEC3, Encyclopedia of Virology Research(Andrew P.Gatto and Benjamin S.Leon (eds))2012

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[Book] Human T-cell Leukemia Virus Type 1(HTLV-1) and Antiviral Enzyme APOBEC32012

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[Book] モデル動物利用マニュアル(中村卓郎編)(第2章 がん、第5節 造血系、遺伝子改変モデル、HTLV-1)2011

Author(s)

OHSUGI TAKEO 大杉剛生

OHSUGI Takeo 大杉剛生

大杉剛生オオスギタケオ

[Book] 九州で多発する白血病－成人T細胞白血病－『熊薬ものがたり　熊本大学薬学部の研究と教育』2014

[Book] 『モデル動物利用マニュアル』疾患モデルの作製と利用　がん2012

[Book] モデル動物利用マニュアル(中村卓郎編)(第2章がん、第5節造血系、遺伝子改変モデル、HTLV-1)2011