Koyama Yutaka 小山豊

… Alternative Names

小山豊コヤマユタカ

KOYAMA Yutaka 小山豊

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Researcher Number	00215435
Other IDs
Affiliation (Current)	2025: 神戸薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 神戸薬科大学, 薬学部, 教授 2015 – 2016: 大阪大谷大学, 薬学部, 教授 2009 – 2011: Otani Womens University, 薬学部, 教授 2001 – 2005: Osaka Univ., Grad. Sch. of Pharmaceutical Sci. Associate Prof., 薬学研究科, 助教授 1999 – 2000: 大阪大学, 薬学研究科, 助手 1990 – 1996: 大阪大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / Applied pharmacology / 応用薬理学・医療系薬学 / Biological pharmacy Except Principal Investigator General pharmacology / 応用薬理学・医療系薬学
Keywords	Principal Investigator エンドセリン / アストロサイト / 脳浮腫 / アストログリア / ETB受容体 / 神経再生 / BDNF / GDNF / グリア細胞 / neurotrophic factors … More / Astrocyte / 神経栄養因子 / focal adhesion kinase / 脳機能改善薬 / 脳傷害 / グルタミン酸 / 神経炎症 / neuroinflammation / brain edema / TBI / astroglia / endothelin / Eph/ephrinシグナル / ＥＴＢ受容体 / Endothelial cells / Blood-Brain Barrier / Brain edema / Astrocytes / Glial cells / 脳血管内皮細胞 / 血液脳関門 / Neurotrophic drugs / Glia cells / Ca交換輸送 / Na / 海馬 / Neurotrophic drug / Brain injury / Endothelin / アクアポリン / 薬理学 / 神経薬理 / FR137319 / BQ788 / 細胞骨格 / gliosis / タウリン / 膨化 … More Except Principal Investigator アストロサイト / グルタミン酸 / T-817 / SEA0400 / アポトーシス / ミクログリア / Brain injury / Astrocyte / 脳傷害 / 脳障害 / IGF-I / エンドセリン / アストログリア / astrocyte / swelling / Zn^<++> / nitric oxide (NO) / mitochondria / cell death / apoptosis / microglia / プロテインキナーゼ / permeability transition pore (PTP) / Ca^<2+> / cyclic GMP / 過酸化水素 / Ca^<2+>交換系 / Na^+ / 神経細胞 / 一酸化窒素(NO) / ミトコンドリア / 細胞死 / Apoptosis / Nerve Degeneration / Microglia / 神経変性 / Na, K-ATPase / Prostaglandins / Endothelins / Glutamic acid / Gliosis / IGF-1 / IGF‐I / Na,K‐ATPase / Na,K-ATPase / プロスタグランジン / グリオーシス / endothelin / glutamate / endothelial cells / astrocytes / cultured cells / brain edema / タウリン / 膨化 / 血液-脳関門 / 脳微小血管内皮細胞 / 培養細胞 / 脳浮腫 / Protein kinase C / NMDA receptor / Glutamate / プロテインキナ-ゼC / NMDA受容体 / protein kinase C / 亜鉛イオン / Swelling / PI代謝亢進 / NMDA / プロテインキナーゼC / Zn^<2+> / 海馬 Less

Development of therapeutic drugs for traumatic brain injury (TBI) to target astroglial endothelin receptorsPrincipal Investigator
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kobe Pharmaceutical University
Development of novel astrocyte-targeted drugs against brain edema and neuronal injuryPrincipal Investigator
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kobe Pharmaceutical University
Research and development of novel neuroprotective drugs targeting endothelin ETB receptorPrincipal Investigator
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kobe Pharmaceutical University
  Osaka Ohtani University
Basic research for novel neurotrophic drugs targeting glial endothelin receptorsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka Ohtani University
Functional alteration of glial cells and brain edema formationPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yutaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University
Studies on molecular mechanisms of anti-apoptotic signals in glial cells
- Principal Investigator
  
  MATSUDA Toshio
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Osaka University
Research and Development of Neuroprotective Drugs Targeted for Glial CellsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yutaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Osaka University
Roles of endothelin receptors in astrocytic activation on brain pathologiesPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Research and Development of Neuroprotective Drugs Based on the Neuron-Glia Interactions
- Principal Investigator
  
  BABA Akemichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
エンドセリン受容体作用薬によるアストログリア機能変化の制御Principal Investigator
- Principal Investigator
  
  小山豊
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
脳傷害時のアストログリア機能変化に対するエンドセリンの役割Principal Investigator
- Principal Investigator
  
  小山豊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
グルタミン酸による神経細胞壊死におけるアストログリア膨化の関与Principal Investigator
- Principal Investigator
  
  小山豊
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Neuropharmacological studies on the roles of glial receptors for neurotransmitters in gliosis
- Principal Investigator
  
  BABA Akemichi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Establishment of in vitro screenin models for new drugs against brain edema
- Principal Investigator
  
  BABA Akemichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Osaka University
Regulation of glutamate neurotransmission by endogenous Zn^<++>
- Principal Investigator
  
  BABA Akemichi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University

[Book] Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury (Rajendram et al. ed) 1st Edition, Chapter 182022
- Author(s)
  Shotaro Michinaga, Yutaka Koyama
- Total Pages
  594
- Publisher
  Elsevier
- ISBN
  9780128230367
- Data Source
  KAKENHI-PROJECT-21K06609
[Book] New developments in astrocytes research2016
- Author(s)
  Koyama Y., Pointer C.B., Vaz A.R., Ito J.
- Total Pages
  147
- Publisher
  Nova Scientific Publishers Inc.
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability2024
- Author(s)
  Michinaga Shotaro、Hishinuma Shigeru、Koyama Yutaka
- Journal Title
  
  Vitamins and Hormones
  
  Volume: 126 Pages: 97-111
- DOI
  10.1016/bs.vh.2024.04.006
- ISBN
  9780443194047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06609
[Journal Article] Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury2023
- Author(s)
  Michinaga Shotaro、Hishinuma Shigeru、Koyama Yutaka
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 5 Pages: 719-719
- DOI
  10.3390/cells12050719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06609
[Journal Article] Isolation and Purification of Harpagogenin as an Nrf2–ARE Activator from the Tubers of Chinese Artichoke (<i>Stachys sieboldii</i>)2023
- Author(s)
  Izumi Y, Kataoka H, Takada-Takatori Y, Koyama Y, Irie K, Akaike A, Kume T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 11 Pages: 1576-1582
- DOI
  10.1248/bpb.b23-00383
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06160, KAKENHI-PROJECT-21K06609
[Journal Article] TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway.2022
- Author(s)
  Izumi Y, Tatsumoto A, Horiuchi N, Arifuku M, Uegomori M, Kume T, Koyama Y.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 149 Issue: 1 Pages: 1-10
- DOI
  10.1016/j.jphs.2022.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07112, KAKENHI-PROJECT-21K06609
[Journal Article] Endothelin-1 decreases the expression of Ephrin-A and B subtypes in cultured rat astrocytes through ETB receptors2021
- Author(s)
  Koyama Yutaka、Tsuboi Sayaka、Mizogui Fuka
- Journal Title
  
  Neuroscience Letters
  
  Volume: 741 Pages: 135393-135393
- DOI
  10.1016/j.neulet.2020.135393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06695
[Journal Article] Endothelin ETB receptor-mediated astrocytic activation: pathological roles in brain disorders.2021
- Author(s)
  Yutaka Koyama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 9 Pages: 4333-4333
- DOI
  10.3390/ijms22094333
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695
[Journal Article] Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury2021
- Author(s)
  Michinaga Shotaro、Koyama Yutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 12 Pages: 6418-6418
- DOI
  10.3390/ijms22126418
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06609, KAKENHI-PROJECT-20K16016
[Journal Article] Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model2021
- Author(s)
  Michinaga Shotaro、Inoue Ayana、Sonoda Kyomi、Mizuguchi Hiroyuki、Koyama Yutaka
- Journal Title
  
  Neurochemistry International
  
  Volume: 146 Pages: 105042-105042
- DOI
  10.1016/j.neuint.2021.105042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-20K16016
[Journal Article] Angiopoietin-1/Tie-2 signal after focal traumatic brain injury is potentiated by BQ788, an ETB receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood-brain barrier function2020
- Author(s)
  Shotaro Michinaga, Ayami Tanabe, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Yukiko Minato, Yu Tujiuchi, Daisuke Miyake, Hiroyuki Mizuguchi, Yutaka Koyama
- Journal Title
  
  Journal of Neurochemistry .
  
  Volume: Online ahead of print Issue: 3 Pages: 0-0
- DOI
  10.1111/jnc.14957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-20K16016
[Journal Article] Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between bosentan and ambrisentan.2020
- Author(s)
  Michinaga Shotaro, Inoue Anna, Yamamoto Hayato, Ryu Ryotaro, Inoue Ayana, Mizuguchi Hiroyuki, Koyama Yutaka.
- Journal Title
  
  Neuropharmacology.
  
  Volume: 175 Pages: 108182-108182
- DOI
  10.1016/j.neuropharm.2020.108182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16016, KAKENHI-PROJECT-18K06695
[Journal Article] Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase?associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes2019
- Author(s)
  Koyama Yutaka、Sumie Satoshi、Nakano Yasutaka、Nagao Tomoya、Tokumaru Shiho、Michinaga Shotaro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 11 Pages: 3920-3933
- DOI
  10.1074/jbc.ra118.005614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-16K18890
[Journal Article] Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage2019
- Author(s)
  Michinaga Shotaro、Koyama Yutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 3 Pages: 571-571
- DOI
  10.3390/ijms20030571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-16K18890
[Journal Article] Delayed Administration of BQ788, an ETB Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood-Brain Barrier Function and a Reduction of Cerebral Edema in Mice.2018
- Author(s)
  Michinaga Shotaro, Kimura Akimasa, Hatanaka Shunichi, Minami Shizuho, Asano Arisa, Ikushima Yuki, Matsui Shingo, Toriyama Yoshiya, Fujii Manami, Koyama Yutaka.
- Journal Title
  
  Journal of neurotrauma
  
  Volume: 印刷中 Issue: 13 Pages: 1481-1494
- DOI
  10.1089/neu.2017.5421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18890, KAKENHI-PROJECT-15K07981
[Journal Article] Astrocyte activation in locus coeruleus is involved in neuropathic pain exacerbation mediated by maternal separation and social isolation stress.2017
- Author(s)
  Nakamoto K, Aizawa F, Kinoshita M, Koyama Y, Tokuyama S.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 8 Pages: 401-401
- DOI
  10.3389/fphar.2017.00401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Dexamethasone down-regulates endothelin receptors and reduces endothelin-induced production of matrix metalloproteinases in cultured rat astrocytes.2017
- Author(s)
  Yutaka Koyama, Ayano Ukita, Kana Abe, Kuniaki Iwamae, Shogo Tokuyama, Keisuke Tanaka, Yuki Kotake
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 印刷中 Issue: 1 Pages: 57-66
- DOI
  10.1124/mol.116.107300
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.2017
- Author(s)
  Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
- Journal Title
  
  PLoS One
  
  Volume: 12(7) Issue: 7 Pages: e0180610-e0180610
- DOI
  10.1371/journal.pone.0180610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10792, KAKENHI-PROJECT-17K08599, KAKENHI-PROJECT-15K07981, KAKENHI-PROJECT-15K10311, KAKENHI-PROJECT-15K10566, KAKENHI-PROJECT-16K15339
[Journal Article] Protection of the Blood–Brain Barrier as a Therapeutic Strategy for Brain Damage2017
- Author(s)
  Shotaro Michnaga, Yutaka Koyama
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 5 Pages: 569-575
- DOI
  10.1248/bpb.b16-00991
- NAID
  130005631954
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981, KAKENHI-PROJECT-16K18890
[Journal Article] Astrocytes Release Polyunsaturated Fatty Acids by Lipopolysaccharide Stimuli2016
- Author(s)
  Aizawa F, Nishinaka T, Yamashita T, Nakamoto K, Koyama Y, Kasuya F, Tokuyama S.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 7 Pages: 1100-1106
- DOI
  10.1248/bpb.b15-01037
- NAID
  130005160776
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981, KAKENHI-PROJECT-15K10566
[Journal Article] Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A.2015
- Author(s)
  Shotaro Michinaga, Naoki Seno, Mayu Fuka, Yui Yamamoto, Shizuho Minami, Marina Nagase, Emi Matsuyama, Daisuke Yamanaka and Yutaka Koyama
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 42 Issue: 6 Pages: 2356-2370
- DOI
  10.1111/ejn.13020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Pathogenesis of brain edema and investigation into anti-edema drugs2015
- Author(s)
  Shotaro Michinaga and Yutaka Koyama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Issue: 5 Pages: 9949-9975
- DOI
  10.3390/ijms16059949
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Functional alterations of astrocytes in mental disorders: pharmacological significance as a drug target2015
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 9 Pages: 261-261
- DOI
  10.3389/fncel.2015.00261
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] I. c. v administration of an endothelin ETB receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain2012
- Author(s)
  Y. Koyama、R. Nagae、S. Tokuyama、K. Tanaka
- Journal Title
  
  Neuroscience
  
  Volume: 192 Pages: 689-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Regulation of astrocytic functions by endothelins : Roles in pathophysiological responses of damaged brain2012
- Author(s)
  Y. Koyama、S. Michinaga
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 401-407
- NAID
  10030571699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Endothelins decrease the expressions of aquaporins and plasma membrane water permeability in cultured rat astrocytes.2011
- Author(s)
  Tanaka K., Koyama Y.
- Journal Title
  
  J Neurosci Res.
  
  Volume: 89 Pages: 320-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] I.c.v administration of an endothelin ET_B receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular end othelial growth factor receptors in rat brain2011
- Author(s)
  Y.Koyama, et al
- Journal Title
  
  Neuroscience
  
  Volume: 192 Pages: 689-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Endothelins decrease the expressions of aquaporins and plasma membrane water permeability in cultured rat astrocytes2011
- Author(s)
  K. Tanaka, Y. Koyama
- Journal Title
  
  J Neurosci Res
  
  Volume: 89 Pages: 320-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Intracerebroventricular administration of an endothelin ETB-receptor agonist increases expression of matrix Metalloproteinase-2 and -9 in Rat Brain.2010
- Author(s)
  Y.Koyama, T.Tanaka
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 114 Pages: 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Intracerebro-ventricular administration of an endothelin ETB-receptor agonist increases expression of matrix metalloproteinase-2 and-9 in rat brain2010
- Author(s)
  Y. Koyama, T. Tanaka
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Characterization of<14>^C-acetate uptake in cultured rat astrocytes2009
- Author(s)
  R. Hosoi, Y. Matsuyama, S. Hirose, Y. Koyama, T. Matsuda, A. Gee, O. Inoue
- Journal Title
  
  Brain Research
  
  Volume: 1253 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ETB receptor agonist2009
- Author(s)
  Y. Koyama, T. Tanaka
- Journal Title
  
  Neuroscience Letters
  
  Volume: 469(3) Pages: 343-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Decreases in rat brain aquaporin-4 expression following intracerebrovent ricular administration of an endothelin ETB receptor agonist2009
- Author(s)
  Y.Koyama, T.Tanaka
- Journal Title
  
  Neuroscience Letters 469(3)
  
  Pages: 343-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590108
[Journal Article] Endothelin Increases the Expressions of Exon III- and IV-Containing Brain-Derived Neurotrophic Factor Transcripts in Cultured Astrocytes and Rat Brain2005
- Author(s)
  Koyama Y.
- Journal Title
  
  J.Neurosci.Res. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes.2005
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Neuroscience 136
  
  Pages: 425-433
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes2005
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Neuroscience 136
  
  Pages: 425-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Endothelin Increases the Expressions of Exon III-and IV-Containing Brain-Derived Neurotrophic Factor Transcripts in Cultured Astrocytes and Rat Brain2005
- Author(s)
  Koyama Y.
- Journal Title
  
  J.Neurosci.Res. (In press)
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Endothelia Increases the Expressions of Exon III- and IV-Containing Brain-Derived Neurotrophic Factor Transcripts in Cultured Astrocytes and Rat Brain2005
- Author(s)
  Koyama Y.
- Journal Title
  
  J.Neurosci.Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes.2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Biochem Pharmacol. 68
  
  Pages: 275-282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Focal adhesion kinase mediates endothelia-induced cyclinD3 expression in rat cultured astrocytes2004
- Author(s)
  Koyama Y.
- Journal Title
  
  J.Neurochem 90
  
  Pages: 904-912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Roles of endothelin in functional alterations of astrocytes on brain injury2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Yakugaku Zasshi 124 (Suppl.2)
  
  Pages: 67-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Development of brain function-improving drugs which target astrocytes.2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Seisan to gijyutu 56
  
  Pages: 44-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  J.Neurochem. 90
  
  Pages: 904-912
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] The selective Na^+-Ca^<2+> exchange inhibitor attenuates brain edema after radiofrequency lesion in rats2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Eur.J.Pharmacol. 489
  
  Pages: 193-196
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Increase by FK960,a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes.2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Biochem.Pharmacol. 68
  
  Pages: 275-282
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] アストロサイトを標的とした脳機能改善薬の開発2004
- Author(s)
  小山豊
- Journal Title
  
  生産と技術 56
  
  Pages: 44-46
- NAID
  40006190457
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] The selective Na^+-Ca^<2+> exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Eur.J.Pharmacol. 489
  
  Pages: 193-196
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Biochem.Pharmacol. 68
  
  Pages: 275-282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Roles of endothelin in functional alterations of astrocytes on brain injury2004
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Yakugaku Zasshi 124(Suppl.2)
  
  Pages: 67-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes2004
- Author(s)
  Koyama Y.
- Journal Title
  
  J.Neurochem 90
  
  Pages: 904-912
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Eur J Pharmacol 489
  
  Pages: 193-196
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] The selective Na-Ca exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Eur J Pharmacol 489
  
  Pages: 193-196
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] FK960, novel cognitive enhancer, stimulates glial cell-induced neurotrophic factor production in cultured astrocytes2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Biochem.Pharmacol. 68
  
  Pages: 275-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Eur J Pharmacol 1489
  
  Pages: 193-196
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Increase by FK960,a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes.2004
- Author(s)
  Koyama Y.
- Journal Title
  
  Biochem Pharmacol. 68
  
  Pages: 275-282
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Endothelin-1 stimulates glial cell line-derived neurotrophic factor expression in cultured rat astrocytes2003
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Biochem.Boiphys.Res.Commun. 303
  
  Pages: 1101-1105
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Endothelia-1 stimulates glial cell line-derived neurotrphic factor (GDNF) expression in cultured astrocytes2003
- Author(s)
  Koyama Y.
- Journal Title
  
  Biochem.Biophis Res.Commun. 303
  
  Pages: 1101-1105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus2003
- Author(s)
  Ikuko Yokoyama
- Journal Title
  
  Cognitive Brain Res. 17
  
  Pages: 522-525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus2003
- Author(s)
  Ikuko Yokoyama
- Journal Title
  
  Brain Res. 17
  
  Pages: 522-525
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Focal adhesion kitiase is required for endothelin-induced cell cycle progression in cultured astrocytcs2003
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Glia 43
  
  Pages: 185-189
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Intracerebroventricular administration of an endothelin ETB receptor agonist increases expressions of GDNF and BDNF in rat brain2003
- Author(s)
  Koyama Y.
- Journal Title
  
  Eur.J.Neurosci. 18
  
  Pages: 887-894
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Focal adhesion kinase is required for endothelia-induced cell cycle progression of cultured astrocytes2003
- Author(s)
  Koyama Y.
- Journal Title
  
  Glia
  
  Pages: 43185-1859
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus.2003
- Author(s)
  Yokoyama I.
- Journal Title
  
  Cogn.Brain Res 17
  
  Pages: 522-525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590466
[Journal Article] Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of GDNF and BDNF in rat2003
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Eur.J.Neurosci. 18
  
  Pages: 887-894
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Journal Article] Focal adhesion kinase is required for endothelin-induced cell cycle progression in cultured astrocytes2003
- Author(s)
  Yutaka Koyama
- Journal Title
  
  Glia 43
  
  Pages: 185-189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370782
[Presentation] 抗酸化ストレス応答転写因子Nrf2の活性化物質探索と作用解析2024
- Author(s)
  泉　安彦、武田紀彦、八巻耕也、久米利明、上田昌史、小山　豊
- Organizer
  日本薬学会　第144年会
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] ミクログリアにおけるNrf2活性化薬TPNA10168による抗炎症性作用の機序2022
- Author(s)
  泉　安彦、小林史佳、八巻耕也、久米利明、小山　豊
- Organizer
  日本薬学会　第142年会
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] BQ788, a selective ETB receptor antagonist alleviates inflammatory reactions after traumatic brain injury in mice2022
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Yasuhiro Ogawa, Shigeru Hishinuma, Yutaka Koyama
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] BQ788, an endothelin ETB receptor antagonist alleviates blood-brain barrier disruption and brain edema after traumatic brain injury2021
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Shigeru Hishinuma Yutaka Koyama
- Organizer
  The Seventeenth International Conference on Endothelin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] エンドセリン受容体拮抗薬ボセンタンの外傷性脳損傷に対する治療効果の検討2021
- Author(s)
  道永昌太郎, 井上杏奈, 龍亮太朗, 大西一也, 稲月直樹, 水口博之, 小山　豊
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 新規Nrf-2活性化薬TPNA10168によるマウス培養アストロサイトでのグルタチオン生合成系の亢進2021
- Author(s)
  中村はるか、寺田夏実、伊藤恭介、泉　安彦、久米利明、小山　豊
- Organizer
  第71 回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] アストロサイトの機能分子を標的とした頭部外傷に対する新規治療薬の開発2021
- Author(s)
  道永昌太郎、水口博之、菱沼滋、小山豊
- Organizer
  生体機能と創薬シンポジウム2021
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] Nrf-2活性化薬TPNA10168によるマウス培養アストロサイトでのグルタチオン生合成系分子の発現増加2021
- Author(s)
  寺田夏実、中村はるか、伊藤恭介、泉　安彦、久米利明、小山　豊
- Organizer
  生体機能と創薬シンポジウム2021
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] エンドセリンETB受容体拮抗薬によるAngiopoietin-1-Tie-2シグナルを介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 神経炎症に対するNrf2活性化薬によるドパミン神経保護作用～人工知能による計数～2020
- Author(s)
  井川紗央里, 泉安彦, 久米利明, 八巻耕也, 小山　豊
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬BQ788によるsonic hedgehogの発現増加を介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 井ノ上彩奈, 園田清美, 水口博之, 小山　豊
- Organizer
  第138回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体を介するアストロサイトNa-K-Cl共輸送体-1(NKCC1)の発現増加2019
- Author(s)
  小山　豊、濱田靖祥、井高佐知子、長田彩夏、道永昌太郎
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬BQ788による頭部外傷マウスにおける血管修復因子Angiopoietin-1の発現増加およびTie-2受容体の活性化2019
- Author(s)
  道永昌太郎、田邉彩美、山本隼人、龍　亮太朗、水口博之、小山豊
- Organizer
  生体機能と創薬シンポジウム2019
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] アストログリアを標的とした脳機能改善薬の開発：BBB保護と脳浮腫の抑制2019
- Author(s)
  小山　豊
- Organizer
  (社)予防薬理学研究所キックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Endothelin-1 stimulates transcription of cyclin D1 and Skp2 through activation of Stat3 in cultured rat astrocytes2019
- Author(s)
  Yutaka Koyama, Satoshi Sumie, Yasutaka Nakano, Tomoya Nagao, Shiho Tokumaru, and Shotaro Michinaga
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Bosentan, an endothelin receptor antagonist ameliorates vasogenic edema after traumatic brain injury in mice2019
- Author(s)
  Shotaro Michinaga, Anna Inoue, Hayato Yamamoto, Ryotaro Ryu, Hiroyuki Mizuguchi, Yutaka Koyama
- Organizer
  The Sixteenth International Conference on Endothelin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリン受容体拮抗薬Bosentanによる頭部外傷後の血管原生脳浮腫に対する抑制効果2019
- Author(s)
  道永昌太郎, 井上杏奈, 山本隼人, 龍亮太朗, 水口博之, 小山豊
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Blockade of endothelin ETB receptor ameliorates brain edema by regulation of astrocyte-derived factors after traumatic brain injury in mice2019
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe, Hayato Yamamoto, Ryotaro Ryu, Hiroyuki Mizuguchi and Yutaka Koyama
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻および脳浮腫に対するエンドセリン受容体拮抗薬Bosentanの効果2019
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 龍　亮太朗, 水口博之, 小山豊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Blockade of endothelin ETB receptor ameliorates blood-brain barrier disruption through increase of angiopoietin-1 after traumatic brain injury in mice2018
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe and Yutaka Koyama
- Organizer
  The 18th World Congress of Basical and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスのBlood-brain barrier破綻に対するエンドセリンETB受容体拮抗薬BQ788による血管修復因子Angiopoietin-1の発現増加を介した抑制効果2018
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻に対するエンドセリンETB受容体拮抗薬の効果2018
- Author(s)
  道永昌太郎、鳥山佳勇、藤井愛望、小山豊
- Organizer
  日本薬学会　第138回年会
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 脳挫傷後の脳血管障害に対するエンドセリンETB受容体拮抗薬の効果2017
- Author(s)
  道永　昌太郎, 小山　豊
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] エンドセリンETB受容体遮断薬BQ788による脳挫傷後の血液脳関門破綻に対する抑制効果の機序解明―VEGF-Aおよびclaudin-5の関与―2017
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村章政, 畠中駿一, 南志津保, 小山豊
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Amelioration of BBB disruption and brain edema by BQ788, an endothelin ETB receptor antagonist through attenuation of matrix metalloproteinase-9 in cerebral contusion mice2017
- Author(s)
  Shotaro Michinaga, Yoshiya Toriyama, Manami Fujii and Yutaka Koyama
- Organizer
  第40回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Effects of endothelin ETB receptor antagonist on acceleration of cerebral microvascular permeability and brain edema formation after fluid percussion injury in mice2016
- Author(s)
  Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami, Arisa Asano, Yuki Ikushima, Shingo Matsui, Yutaka Koyama
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜　（神奈川県、横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Fluid percussion injury後のマウス脳浮腫に対するエンドセリン受容体遮断薬の効果―ETA遮断薬とETB遮断薬の異なる効果―2016
- Author(s)
  道永昌太郎, 木村章政, 畠中駿一, 南志津保, 麻野有沙, 生島佑起, 松井伸悟, 小山豊
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館 (広島県、広島市)
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Attenuation of fluid percussion injury induced-brain edema formation by BQ788, an endothelin ETB receptor antagonist, in mice2016
- Author(s)
  Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami and Yutaka Koyama
- Organizer
  第89回　日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 流体衝撃による脳傷害後のマウス脳浮腫に対するエンドセリンETB受容体遮断薬の効果 ―血管透過性亢進因子VEGF-Aの関与―2016
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村光克, 畠中駿一, 南志津保, 小山豊
- Organizer
  第66 回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学　（大阪府、高槻市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 培養アストロサイトでのエンドセリンによるVEGF-R1の発現変化と受容体シグナル系の増強2016
- Author(s)
  小山　豊、林　美央、小西智洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Regulation of animal behaviors through brain reward system: Mechanisms underlying pleasure and aversion2015
- Author(s)
  Yutaka Koyama
- Organizer
  The 25th International symposium of itch
- Place of Presentation
  奈良春日野国際フォーラム　甍　能楽ホール（奈良県、奈良市）
- Year and Date
  2015-09-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] エンドセリンによるアストロサイトの転写因子Sp1の活性化: MCP-1およびCINC-1産生への関与2012
- Author(s)
  道永昌太郎、小山豊
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都市
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21590108
[Presentation] エンドセリンによるラット大脳でのVEGF-A産生促進とVEGF受容体の活性化2011
- Author(s)
  小山豊、永江隆二、徳山尚吾、田中一裕
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀市
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21590108
[Presentation] グリア細胞-more than just brain glue2011
- Author(s)
  小山豊
- Organizer
  第54回日本神経化学会大会神経科学カレッジ
- Place of Presentation
  加賀市
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21590108
[Presentation] エンドセリンによるラット大脳および培養アストロサイトでのアクアポリンの発現変化2010
- Author(s)
  小山豊、田中一裕
- Organizer
  生体機能と創薬シンポジウム2010京都
- Place of Presentation
  京都市
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21590108
[Presentation] 培養アストロサイトおよびラット大脳皮質におけるVEGF発現に対するエンドセリンの作用2010
- Author(s)
  田中一裕、小山豊
- Organizer
  日本薬理学会
- Place of Presentation
  大阪
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21590108
[Presentation] 培養アストロサイトにおけるアクアポリン4発現と水透過性に対するエンドセリンの作用2009
- Author(s)
  田中一裕、小山豊
- Organizer
  日本神経科学会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21590108

1. BABA Akemichi (70107100)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. MATUDA Toshio (00107103)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. HASHIMOTO Hitoshi (30240849)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 道永昌太郎 (60624054)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
5. 泉安彦 (60456837)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. SHIGENAGA Yoshio (90028770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中一裕 (80454586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. 岩田平太郎 (30028823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 栗原崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 宮山篤郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koyama Yutaka 小山 豊

小山 豊 コヤマ ユタカ

KOYAMA Yutaka 小山 豊

Research Projects

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Development of therapeutic drugs for traumatic brain injury (TBI) to target astroglial endothelin receptorsPrincipal Investigator

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Development of novel astrocyte-targeted drugs against brain edema and neuronal injuryPrincipal Investigator

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Research and development of novel neuroprotective drugs targeting endothelin ETB receptorPrincipal Investigator

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Basic research for novel neurotrophic drugs targeting glial endothelin receptorsPrincipal Investigator

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Functional alteration of glial cells and brain edema formationPrincipal Investigator

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Studies on molecular mechanisms of anti-apoptotic signals in glial cells

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Research and Development of Neuroprotective Drugs Targeted for Glial CellsPrincipal Investigator

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Roles of endothelin receptors in astrocytic activation on brain pathologiesPrincipal Investigator

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Research and Development of Neuroprotective Drugs Based on the Neuron-Glia Interactions

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エンドセリン受容体作用薬によるアストログリア機能変化の制御Principal Investigator

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脳傷害時のアストログリア機能変化に対するエンドセリンの役割Principal Investigator

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グルタミン酸による神経細胞壊死におけるアストログリア膨化の関与Principal Investigator

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Neuropharmacological studies on the roles of glial receptors for neurotransmitters in gliosis

Principal Investigator

Koyama Yutaka 小山豊

小山豊コヤマユタカ

KOYAMA Yutaka 小山豊