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HAYASHI Sachiko  林 幸子

ORCIDConnect your ORCID iD *help
Researcher Number 00218570
Other IDs
Affiliation (based on the past Project Information) *help 2007 – 2012: University of Fukui, 医学部, 助教
2003 – 2006: Faculty of Medical Science, University of Fukui, Department of Experimental Radiology and Health Physics, Assistant Professor, 医学部, 助手
1998 – 2002: 福井医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Radiation science
Except Principal Investigator
Radiation science / Biological Sciences
Keywords
Principal Investigator
DNA topoisomerase II / 放射線増感効果 / A549細胞 / パルテノライド / ras gene / amrubicin (amrubicinol) / p53 gene / human lung adenocarcinoma A549 cells / radio-enhancement effect / enhancement effect … More / radiosenssitivity / Human Lung carcinoma A549 cells / TopoII標的制癌剤 / DNA Topoisomerase II / ras遺伝子 / Amrubicin / p53遺伝子 / ヒト肺癌A549細胞 / PC3細胞 / DU145細胞 / NF-κB阻害剤 / DU145 細胞 / ras/raf/MAPK / Apoptosis / NF-κB 阻害剤 / NF-κB / アポトーシス … More
Except Principal Investigator
p53 / 放射線感受性 / 細胞間シグナル伝達系 / バイスタンダー効果 / Hsp72 / Hsp70 / 癌温熱療法 / 癌放射線治療 / Nitric Oxide / Inducible Nitric Oxide Synthase / X-rays / アポトーシス / Apoptosis / Drug for angina pectoris / Hyperthermia / Radiotherapy / NSCLC / SCC / Nitric oxide発生剤 / Nitric oxide / 放射線 / NOラジカル発生剤 / 温熱療法 / 放射線治療 / apoptopsis / apoptosis / 狭心症治療薬 / ヒト非小細胞肺癌 / ヒト舌扁平上皮癌 / Bystander effect / Radiosensitivity / Intercellular signal transduction / Intracellular signal transduction / Inducible nitric oxide synthase / Glioma / Conditioned Medium / ヒト舌扁平上皮癌細胞 / 細胞内シグナル伝達系 / hsp72 / 誘導型NO合成酵素 / ヒト神経膠芽腫細胞 / 放射線誘発バイスタンダー効果 / 放射線適応応答 / NOラジカル / iNOS / 熱帯産生薬成分 / 細胞周期応答 / p53遺伝子及び蛋白 / 集学的制がん実験 / 温熱感受性 Less
  • Research Projects

    (8 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (12 People)
  •  Radio-enhancement effects by Parthenolide, NF-κB inhibitor, and analysis of these molecular mechanism.Principal Investigator

    • Principal Investigator
      HAYASHI Sachiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      University of Fukui
  •  The investigation of mechanisms about apoptosis induction by transcription factor NF-κB inhibitor parthenolide.Principal Investigator

    • Principal Investigator
      HAYASHI Sachiko
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      University of Fukui
  •  Molecular mechanisms of radio-enhancement with the topoII target in human lung adenocarcinoma A549 cells.Principal Investigator

    • Principal Investigator
      HAYASHI Sachiko
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      University of Fukui
  •  放射線治療におけるNOラジカルによる放射線誘発Bystander効果の役割

    • Principal Investigator
      松本 英樹
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      福井医科大学
  •  Application of NO generating agents as radiosensitizer and their modes of action.

    • Principal Investigator
      MATSUMOTO Hideki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Faculty of Medical Sciences, University of Fukui
  •  放射線治療における放射線誘発Bystander効果の発現機構とその役割

    • Principal Investigator
      MATSUMOTO Hideki
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      福井医科大学
  •  Modification of Cellular Response by Changes in Microenvironment Caused by Radiation-Induced Nitric Oxide Production and Mechanisms.

    • Principal Investigator
      MATUMOTO Hideki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Fukui Medical University
  •  がん関連遺伝子が及ぼす放射線効果への影響

    • Principal Investigator
      KANO Eiichi
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Radiation science
    • Research Institution
      福井医科大学

All 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

  • [Journal Article] Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines2011

    • Author(s)
      S.HAYASHI, et.al
    • Journal Title

      Int.J.Mol.Med.

      Volume: 28 Pages: 1033-1042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Journal Article] Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines2011

    • Author(s)
      HAYASHI SACHIKO, KOSHIBA KEN, HATASHITA MASANORI, SATO TAKEFUMI, JUJO YUTAKA, SUZUKI RYUTA, TANAKA YUKIE and SHIOURA HIROKI
    • Journal Title

      International Journal ofMolecular Medicine

      Volume: 28 Pages: 1033-1042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Journal Article] Inhibition of NF-κB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells2010

    • Author(s)
      Hayashi S, Sakurai H, Hayashi A, Tanaka Y, Hatashita M, Shioura H
    • Journal Title

      Int J Mol Med 25

      Pages: 81-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Journal Article] Inhibition of NF-κB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell-cycle arrest in human lung adenocarcinoma cells2010

    • Author(s)
      HAYASHI SACHIKO, SAKURAI HIROAKI, HAYASHI AKIO, TANAKA YUKIE, HATASHITA MASANORI and SHIOURA HIROKI
    • Journal Title

      International Journal ofMolecular Medicine

      Volume: 25 Pages: 81-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Journal Article] Inhibition of NF-κB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells.2010

    • Author(s)
      S Hayashi, et al.
    • Journal Title

      Int.J.Mol.Med. 25

      Pages: 81-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Journal Article] Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53-and hsp72-independent apoptosis induction via the nuclear factor-κB signal pathway.2008

    • Author(s)
      S Hayashi, et al.
    • Journal Title

      Int. J. Mol. Med. 21

      Pages: 585-592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Journal Article] Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53-and hsp72-independent apoptosis induction via the nuclear factor-κB signal pathway.2008

    • Author(s)
      S Hayashi, et. al.
    • Journal Title

      Int. J. Mol. Med. 21

      Pages: 585-592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Journal Article] Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and Amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.2006

    • Author(s)
      S Hayashi, et al.
    • Journal Title

      Int. J. Mol. Med. 18

      Pages: 909-915

    • NAID

      120000807641

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591196
  • [Journal Article] Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.2006

    • Author(s)
      S Hayashi, et al.
    • Journal Title

      Int. J. Mol. Med. 18

      Pages: 909-915

    • NAID

      120000807641

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591196
  • [Journal Article] Modification of thermosensitivity by amrubicin or amrubicinol in human lung adenocarcinoma A549 cells and the kinetics of apoptosis and necrosis induction2005

    • Author(s)
      Hayashi s, hatashita M, Matsumoto M, et al.
    • Journal Title

      Int J Molecular Medicine 16

      Pages: 381-387

    • NAID

      120000807709

    • Data Source
      KAKENHI-PROJECT-16591196
  • [Journal Article] P53-independent thermosensitization by mitomycin C in human non-small-cell lung cancer cells2004

    • Author(s)
      Jin ZH, Matsumoto H, Hayashi S, et al.
    • Journal Title

      Int.J.Radiation Oncology Biol.Phys. 59

      Pages: 852-860

    • Data Source
      KAKENHI-PROJECT-16591196
  • [Presentation] Thermosensitization by parthenolide, a NF-κB inhibitor, and apoptosis induction or cell-cycle arrest via the MAPK cascade2012

    • Author(s)
      Hayashi Sachiko, Hatashita Masanori, Koshiba Ken, Sato Takefumi, Jujo Yutaka, Suzuki Ryuta, Shiozaki Hisaya
    • Organizer
      17th World Congress on Advances in Oncology & 15th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2012-10-12
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] hermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer cell lines.2012

    • Author(s)
      Sachiko Hayashi
    • Organizer
      11th International Conference Hyperthermic Oncology & 29th Japanese Conferences of Thermal Medicine
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer cell lines2012

    • Author(s)
      HAYASHI Sachiko, KOSHIBA Ken, SHIOZAKI Hisaya, HATASHITA Masanori, SATO Takefumi, JUJO Yutaka, SUZUKI Ryuta
    • Organizer
      11th International Conference on Hyperthermic Oncology & 第29回日本ハイパーサーミア学会
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-08-30
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] Thermosensitization by parthenolide, a NF-κB inhibitor, and apoptosis induction or cell-cycle arrest via the MAPK cascade2012

    • Author(s)
      Sachiko Hayashi
    • Organizer
      17th World Congress on Advances in Oncology & 15th International Symposium on Molecular Medicine
    • Place of Presentation
      Greece
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction2011

    • Author(s)
      HAYASHI SACHIKO, HATASHITA MASANORI, SHIOURA HIROKI, TANAKA YUKIE
    • Organizer
      14th International Congress Radiation Research, Poland
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2011-08-29
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction2011

    • Author(s)
      林幸子
    • Organizer
      14th ICRR
    • Place of Presentation
      Warsaw, POLAND
    • Year and Date
      2011-08-25
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト前立腺癌細胞におけるパルテノライドによる温熱増感効果とapoptosis誘導又はcell-cycle arrest2011

    • Author(s)
      林幸子
    • Organizer
      第28回日本ハイパーサーミア学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト前立腺癌細胞における NF-κB 阻害剤パルテノライドの温熱増感効果と MAPK cascade 経由 apoptosis 誘導及び cellcycle arrest2011

    • Author(s)
      林 幸子、畑下昌範、田中幸枝
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-18
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト前立腺癌細胞におけるパルテノライドによる温熱増感効果と apoptosis 誘導及び cell-cycle arrest2011

    • Author(s)
      林 幸子、畑下昌範、塩浦宏樹
    • Organizer
      第28回日本ハイパーサーミア学会
    • Place of Presentation
      愛知
    • Year and Date
      2011-09-09
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト前立腺癌細胞におけるパルテノライドの温熱増感効果と apoptosis 誘導及びcell-cycle arrest2011

    • Author(s)
      林 幸子、畑下昌範、塩浦宏樹
    • Organizer
      第13回関西ハイパーサーミア研究会
    • Place of Presentation
      長岡京市
    • Year and Date
      2011-07-02
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト前立腺癌細胞におけるNF-κB阻害剤パルテノライドによる温熱増感効果とMAPK cascade経由apoptosis誘導又はcell-cycle arrest2011

    • Author(s)
      林幸子
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-18
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] アンドロゲン非依存性前立腺癌細胞におけるNF-κB 阻害剤 Parthenolide の温熱増感効果及び MAPK カスケードへの影響2010

    • Author(s)
      林 幸子、畑下昌範、塩浦宏樹
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-22591381
  • [Presentation] ヒト肺癌A549細胞におけるパルテノライド及び温熱併用によるNF-κBの阻害効果とアポトーシス誘導2009

    • Author(s)
      林幸子、櫻井宏明.
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるパルテノライド及び温熱併用によるNF-κBの阻害効果とアポトーシス誘導2009

    • Author(s)
      林幸子
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] The effects of combination therapy with hyperthermia and parthenolide on survivals of human lung cancer A549 cells2009

    • Author(s)
      Hayashi S, Hatashita M.
    • Organizer
      25th Annual Meeting of the European Society for Hyperthermic Oncology
    • Place of Presentation
      Verona in Italy
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] A549細胞における温熱及びパルテノライド併用によるNF-κBの阻害効果2009

    • Author(s)
      林幸子、櫻井宏明.
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Place of Presentation
      千葉
    • Year and Date
      2009-09-12
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] The effects of combination therapy with hyperthermia and parthenolide on survivals of human lung cancer A549 cells.2009

    • Author(s)
      林幸子, et al.
    • Organizer
      25th European Society of Hyperthermic Oncology
    • Place of Presentation
      Verona, Italy
    • Year and Date
      2009-06-06
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるパルテノライド及び温熱併用によるNF-κB活性阻害効果とアポトーシス誘導2009

    • Author(s)
      林幸子、畑下昌範
    • Organizer
      第11回関西ハイパーサーミア研究会第20回高温度療法臨床研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] A549細胞における温熱及びパルテノライド併用によるNF-κBの阻害効果2009

    • Author(s)
      林幸子
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Place of Presentation
      千葉市
    • Year and Date
      2009-09-19
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるパルテノライド及び温熱併用によるNF-κB活性阻害効果とアポトーシス誘導2009

    • Author(s)
      林幸子
    • Organizer
      第11回関西ハイパーサーミア研究会 第20回高温度療法臨床研究会 合同研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-07-25
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and apoptosis induction via NF-κB signal pathway.2008

    • Author(s)
      S Hayashi, et al.
    • Organizer
      10th Int. Congr. Hyperthermic Oncol.
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2008-04-09
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] Parthenolideの温熱増感効果とNF-κB阻害経路によるアポトーシス誘導への影響2008

    • Author(s)
      林幸子
    • Organizer
      第25回日本ハイパーサーミア学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-09-12
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] The thermo-enhancement effects of NF-κB inhibitor, Parthenolide, and the mechanisms of apoptosis induction.2008

    • Author(s)
      林幸子
    • Organizer
      第51回日本放射線影響学会
    • Place of Presentation
      北九州市
    • Year and Date
      2008-11-19
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるNF-κB阻害剤Parthenolideの温熱増感効果2007

    • Author(s)
      林 幸子
    • Organizer
      日本放射線影響学会 第50回大会
    • Place of Presentation
      千葉市
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるNF-κB阻害剤Parthenolideの温熱増感効果2007

    • Author(s)
      林 幸子
    • Organizer
      日本ハイパーサーミア学会 第24回大会
    • Place of Presentation
      前橋市
    • Year and Date
      2007-09-14
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] The relation of p53 status to the radio- or thermo-enhancement effect by Adriamycin(ADM)in human lung adenocarcinoma A549 cells and kinetics of apoptosis and hsp72 protein.2007

    • Author(s)
      S. Hayashi
    • Organizer
      13th Int. Congr. Radiat. Res.
    • Place of Presentation
      SanFrancisco, USA
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-19591456
  • [Presentation] ヒト肺癌A549細胞におけるNF-κB阻害剤Parthenolideの温熱増感効果2007

    • Author(s)
      林 幸子
    • Organizer
      第9回関西ハイパーサーミア研究会、第17回高温度療法臨床研究会 合同研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-06-23
    • Data Source
      KAKENHI-PROJECT-19591456
  • 1.  MATSUMOTO Hideki (40142377)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 2 results
  • 2.  KANO Eiichi (70065910)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  HATASHITA Masanori (40359237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  JIN Zhao-hui (70324150)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  三橋 紀夫 (20008585)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  大西 武雄 (60094554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  西村 恭昌 (00218207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  片山 寛次 (30204431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  上田 公介 (20128648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  新部 英男 (90008293)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  井上 俊彦 (70028512)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  増田 康治 (10037377)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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