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Watanabe Shiro  渡辺 志朗

… Alternative Names

SHIRO Watanabe  渡辺 志朗

WATANABE Shiro  渡辺 志朗

渡辺 志朗  ワタナベ シロウ

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Researcher Number 00222406
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4435-6992
Affiliation (Current) 2025: 富山大学, 学術研究部薬学・和漢系, 准教授
Affiliation (based on the past Project Information) *help 2024: 富山大学, 学術研究部薬学・和漢系, 准教授
2019 – 2020: 富山大学, 学術研究部薬学・和漢系, 准教授
2011 – 2018: 富山大学, 和漢医薬学総合研究所, 准教授
1999 – 2001: 富山医科薬科大学, 和漢薬研究所, 助教授
1997 – 1998: 名古屋市立大学, 薬学部, 講師
1993: 名古屋市立大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 59040:Nutrition science and health science-related / Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) / General internal medicine (including Psychosomatic medicine)
Except Principal Investigator
Gastroenterology / Eating habits / 矯正・小児・社会系歯学 / Biological pharmacy
Keywords
Principal Investigator
胆汁酸 / マクロファージ / リトコール酸 / FXR / ドコサヘキサエン酸 / エイコサペンタエン酸 / 炎症性サイトカイン / 脂肪性肝炎 / 透過性 / 腸管上皮細胞 … More / glucagon-like peptide-1 / FGF15/19 / farnesoid X 受容体 / 16s rRNA / TGR5 / 飽和脂肪酸 / 16sRNA遺伝子 / 腸管吸収 / 糞便脂質排泄 / 2次胆汁酸 / 腸内細菌 / ムリコール酸 / デオキシコール酸 / farnesoid X receoptor / 疎水性 / OSTβ / MRP3 / BSEP / cyp3a11 / 代謝 / 排泄 / 吸収 / 小腸 / 肝臓 / 胆汁うっ滞性肝疾患 / 核内受容体 / VDR / CAR / 硫酸抱合化 / 水酸化 / トランスポーター / リポプロテインリパーゼ / 肝傷害 / コール酸 / トランスアミナーゼ / コレステロールエステル / ステアリン酸CoA不飽和化酵素1 / ステアリン酸CoA不飽和化酵素1 / 一価不飽和脂肪酸 / トリグリセリド / 寿命 / ストレプトゾトシン / HMG-CoA還元酵素 / マウス / 食餌 / 脂肪酸 / 肝障害 / ロイコトリエンB4 / 多形核白血球 / α-リノレン酸 / インスリン低抗性 / 四塩化炭素 / インターロイキンlB / 血小板活性化因子 / d-リル_2酸 / 遺伝子発現 / プロスタグランジンE2 / 腫瘍壊死因子 / 食餌必須脂肪酸 / リノール酸 / alpha-リノレン酸 … More
Except Principal Investigator
炎症 / α‐リノレン酸 / α-リノレン酸 / 上皮細胞 / 結腸 / メチル化 / 伸展 / ATP / 胃 / VNUT / TRPV4 / ATP放出 / 伸展刺激 / 消化管上皮 / 海馬神経細胞死 / 摂食障害 / 脳虚血モデルマウス / intervention study / fatty acid composition / rapeseed oil / soybean oil / perilla oil / aphthous stomatitis / 二重盲検法 / 植物油 / シソ油 / 介入試験 / 脂肪酸構成 / なたね油 / 大豆油 / しそ油 / 口内炎 / nerve growth factor / monoamine / acetylcholine / learning ability / eicosapentaenoic acid / docosahexaenoic acid / linoleic aicd / alpha-linolenic acid / AMPA受容体 / 神経成長因子 / モノアミン / アセチルコリン / 学習能 / エイコサペンタエン酸 / ドコサヘキサエン酸 / リノール酸 Less
  • Research Projects

    (11 results)
  • Research Products

    (81 results)
  • Co-Researchers

    (27 People)
  •  Mechanistic elucidation of the preventive effect of pig-derived bile acids on life-related diseases through the improvement of gut barrier impairmentPrincipal Investigator

    • Principal Investigator
      渡辺 志朗
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      University of Toyama
  •  Experimental assessment of preventive effects of kampo medicines against metabolic syndromes through the modification of intestinal bile acid metabolismPrincipal Investigator

    • Principal Investigator
      Watanabe Shiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      University of Toyama
  •  Evaluation of protective effect of dietary supplementation with n-3 fatty acids against feeding disorder following cerebral ischemia in mice

    • Principal Investigator
      Doshi Masaru
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits
    • Research Institution
      Teikyo University
  •  Role of pregnane X receptor in the preventive effect of Boiogito against experimentally induced cholestatic liver injuryPrincipal Investigator

    • Principal Investigator
      Watanabe Shiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      University of Toyama
  •  Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epithelium

    • Principal Investigator
      Mihara Hiroshi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Detection of novel actions of kampo medicines for lipid metabolism by lipidomic analysisPrincipal Investigator

    • Principal Investigator
      SHIRO Watanabe
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      University of Toyama
  •  Prevention of aphtous stomatitis with α-linolenic acid -a double-blind study-

    • Principal Investigator
      HAMAZAKI Tomohito
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      矯正・小児・社会系歯学
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  食餌n-3系不飽和脂肪酸がII型糖尿病に及ぼす影響とその機構の解析Principal Investigator

    • Principal Investigator
      渡辺 志朗
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  食餌性n-3系不飽和脂肪酸の生理・病態に及ぼす影響の基礎的研究Principal Investigator

    • Principal Investigator
      渡辺 志朗
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagoya City University
  •  Mechanisms by which dietary oils affect behavioral patterns of rats

    • Principal Investigator
      OKUYAMA Harumi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagoya City University
  •  食餌必須脂肪酸バランスによる腫瘍壊死因子(TNF)産生制御の機構に関する研究Principal Investigator

    • Principal Investigator
      渡辺 志朗
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagoya City University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] 日本人は絶滅危惧民族 -誤った脂質栄養が拍車―2019

    • Author(s)
      大原直樹、小林哲幸、浜 六郎、内野 元、岩本晃明、橋本道男、籠橋有紀子、渡辺志朗、坂井恵子、橋本洋子、立松憲次郎、市川祐子、大西浩之、日比野英彦.
    • Total Pages
      126
    • Publisher
      中日出版
    • ISBN
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Journal Article] Regulation of lipogenesis by bile acids2020

    • Author(s)
      渡辺 志朗
    • Journal Title

      生化学

      Volume: 92 Issue: 5 Pages: 680-687

    • DOI

      10.14952/SEIKAGAKU.2020.920680

    • ISSN
      0037-1017
    • Year and Date
      2020-10-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Journal Article] Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity2020

    • Author(s)
      Fujisaka Shiho、Usui Isao、Nawaz Allah、Igarashi Yoshiko、Okabe Keisuke、Furusawa Yukihiro、Watanabe Shiro、Yamamoto Seiji、Sasahara Masakiyo、Watanabe Yoshiyuki、Nagai Yoshinori、Yagi Kunimasa、Nakagawa Takashi、Tobe Kazuyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5544-5544

    • DOI

      10.1038/s41598-020-62506-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18F18102, KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-17K09821, KAKENHI-PROJECT-18K10204, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-18K07441, KAKENHI-PROJECT-18K08505
  • [Journal Article] Boiogito extract alters fecal bile acid profile in mice: Possible roles in changes in fecal and liver lipid levels2020

    • Author(s)
      Chen Zhuoer、Watanabe Shiro、Nishidono Yuto、Tanaka Ken
    • Journal Title

      Traditional & Kampo Medicine

      Volume: 7 Issue: 3 Pages: 138-145

    • DOI

      10.1002/tkm2.1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Journal Article] Boiogito prevents dietary lithocholic acid (LCA)‐induced cholestatic liver injury through the suppression of intestinal LCA absorption2019

    • Author(s)
      Watanabe Shiro、Chen Zhuoer、Fujita Kyosuke
    • Journal Title

      Traditional & Kampo Medicine

      Volume: 6 Issue: 2 Pages: 71-78

    • DOI

      10.1002/tkm2.1214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Journal Article] Ameliorative effect of animal bile preparations on dextran sulfate sodium-induced colitis in mice2018

    • Author(s)
      Watanabe Shiro、Fujita Kyosuke、Nishida Takeshi、Imura Johji
    • Journal Title

      Traditional & Kampo Medicine

      Volume: 5 Issue: 2 Pages: 67-74

    • DOI

      10.1002/tkm2.1094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07441, KAKENHI-PROJECT-17K17746
  • [Journal Article] Ursodeoxycholic acid suppresses lipogenesis in mouse liver: possible role of the decrease in β-muricholic acid, a farnesoid X receptor antagonist.2017

    • Author(s)
      Fujita K., Iguchi Y., Une M., Watanabe S.
    • Journal Title

      Lipids

      Volume: 52 Issue: 4 Pages: 335-344

    • DOI

      10.1007/s11745-017-4242-5

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Journal Article] Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium2017

    • Author(s)
      Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa,Toshiro Sugiyama
    • Journal Title

      Helicobacter

      Volume: 22 Issue: 2

    • DOI

      10.1111/hel.12361

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Journal Article] Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice2016

    • Author(s)
      Watanabe S, Fujita K, Tsuneyama K, Nose M.
    • Journal Title

      Trad Kampo Med

      Volume: 3 Issue: 1 Pages: 9-19

    • DOI

      10.1002/tkm2.1032

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Journal Article] Dipasperoside B, a new trisiridoid glucoside from Dipsacus asper.2016

    • Author(s)
      Li F., Tanaka K., Watanabe S., Tezuka Y.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 11 Pages: 891-894

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Journal Article] A novel method for determining peroxisomal fatty acid β-oxidation.2016

    • Author(s)
      Masashi Morita, Shun Matsumoto, Airi Okazaki, Kaito Tomita, Shiro Watanabe, Kosuke Kawaguchi, Daishiro Minato, Yuji Matsuya, Nobuyuki Shimozawa, Tsuneo Imanaka.
    • Journal Title

      J Inherit Metab Dis

      Volume: 39 Issue: 5 Pages: 725-731

    • DOI

      10.1007/s10545-016-9952-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04875, KAKENHI-PROJECT-26460063, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-15K15389
  • [Journal Article] Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia2016

    • Author(s)
      Mihara H, Sugiyama , et al.
    • Journal Title

      World J Gastroenterol.

      Volume: 22 Issue: 24 Pages: 5512-5519

    • DOI

      10.3748/wjg.v22.i24.5512

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-26870214
  • [Journal Article] Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase.2015

    • Author(s)
      Morita M, Kawamichi M, Shimura Y, Kawaguchi K, Watanabe S, Imanaka T.
    • Journal Title

      Metab Brain Dis

      Volume: 30 Issue: 6 Pages: 1359-1367

    • DOI

      10.1007/s11011-015-9701-1

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460063, KAKENHI-PROJECT-26460903
  • [Journal Article] Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia.2015

    • Author(s)
      Niu Y, Li F, Inada C, Tanaka K, Watanabe S, Fujiwara H, Sasaki-Hamada S, Oka J, Matsumoto K.
    • Journal Title

      J Pharm Biomed Anal.

      Volume: 104 Pages: 21-30

    • DOI

      10.1016/j.jpba.2014.11.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Journal Article] Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues.2014

    • Author(s)
      Watanabe S, Fujita K.
    • Journal Title

      Lipids

      Volume: 49 Issue: 10 Pages: 963-973

    • DOI

      10.1007/s11745-014-3947-y

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Journal Article] Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage2014

    • Author(s)
      Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.
    • Journal Title

      Am. J. Physiol. Gastrointest. Liver Physiol.

      Volume: 307 Issue: 1 Pages: G33-G40

    • DOI

      10.1152/ajpgi.00105.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-26870214
  • [Journal Article] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet2013

    • Author(s)
      Watanabe S., Tsuneyama K
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 38 Issue: 3 Pages: 379-390

    • DOI

      10.2131/jts.38.379

    • NAID

      10031158904

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet2013

    • Author(s)
      Watanabe S., Tsuneyama K.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Pages: 379-390

    • NAID

      10031158904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of <i>Dipsacus asper</i>2013

    • Author(s)
      Li F., Tanaka K., Watanabe S., Tezuka Y., Saiki I.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 61 Issue: 12 Pages: 1318-1322

    • DOI

      10.1248/cpb.c13-00546

    • NAID

      130003381796

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Pig bile reduces hepatic triglyceride content in mice2013

    • Author(s)
      Watanabe S., Fujita K.
    • Journal Title

      J. Trad. Med.

      Volume: 30 Pages: 190-197

    • NAID

      130004942435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis2013

    • Author(s)
      Tanaka K., Li F., Tezuka Y., Watanabe S., Kawahara N., Kida H.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 8 Pages: 75-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Pig bile reduces hepatic triglyceride content in mice.2013

    • Author(s)
      Watanabe S., Fujita K
    • Journal Title

      J. Trad. Med.

      Volume: 30 Pages: 190-197

    • NAID

      130004942435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.2012

    • Author(s)
      Watanabe S., Tsuneyama K.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 105-121

    • NAID

      10030037499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS.2012

    • Author(s)
      Watanabe K, Ishikawa C, Kuwahara H, Sato K, Komuro S, Nakagawa T, Nomura N, Watanabe S, Yabuki M.
    • Journal Title

      Anal. Bioanal. Chem.

      Volume: 402 Pages: 2033-2042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice : mediation by cholic acid2012

    • Author(s)
      Watanabe S., Tsuneyama K.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 105-121

    • NAID

      10030037499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Journal Article] Cattle bile aggravates diclofenac sodium-induced small intestinal injury in mice2011

    • Author(s)
      Ishikawa H., Watanabe S.
    • Journal Title

      Evid. Based. Complement. Alternat. Med.

      Volume: 315858 Issue: 1 Pages: 1-8

    • DOI

      10.1155/2011/315858

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] ヒオデオキシコール酸がマウスにおける糞便中への脂質排泄に及ぼす影響2021

    • Author(s)
      渡辺 志朗, 陳 卓爾
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] 五苓散がマウスの糞便中脂質プロファイルに及ぼす影響2020

    • Author(s)
      渡辺志朗, 馬 青苗, 陳 卓爾
    • Organizer
      和漢医薬学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] 甲状腺ホルモンがマウス脳虚血再潅流後の神経細胞死の発生に及ぼす影響2020

    • Author(s)
      道志 勝、渡辺 志朗、名取 雄人、細山田 真、赤江 豊
    • Organizer
      本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] がん悪液質モデルマウスに対するオレアノール酸の効果2020

    • Author(s)
      藤田 恭輔、茶谷 大輝、濱田 和花、渡辺 志朗
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] マウスにおける糞便中への脂質排泄に及ぼす五苓散と猪苓湯の影響2020

    • Author(s)
      渡辺 志朗、馬 青苗、陳 卓爾
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] アラキドン酸による容積感受性外向き整流性Cl-チャネルの制御2019

    • Author(s)
      吉住志萌、清水貴浩、藤田恭輔、藤井拓人、渡辺志朗、酒井秀紀
    • Organizer
      日本薬学会北陸支部 第13
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] 防己黄耆湯はリトコール酸(LCA)の腸管での吸収を抑制することによって胆汁うっ滞性肝傷害を軽減する.2019

    • Author(s)
      陳 卓爾、渡辺 志朗、 藤田 恭輔.
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] エゴマ(Perilla frutescence)の葉の摂取ががん悪液質モデルに与える効果2019

    • Author(s)
      藤田恭輔、濱田和花、茶谷大輝、渡辺志朗
    • Organizer
      和漢医薬学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] Boiogito modifies bile acid profiles in feces but not liver and cecum in mice.2019

    • Author(s)
      陳 卓爾、加賀谷元太、渡辺志朗
    • Organizer
      和漢医薬学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] リトコール酸誘発性胆汁うっ滞モデルにおける肝傷害と肝臓内胆汁蓄積に対する防己黄耆湯の防御効果.2018

    • Author(s)
      渡辺志朗、陳 卓爾、加賀谷元太、藤田恭輔.
    • Organizer
      和漢医薬学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07441
  • [Presentation] α-リノレン酸の給餌がマウス脳内炎症応答に及ぼす影響2018

    • Author(s)
      道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K00848
  • [Presentation] α‐リノレン酸の給餌が脳リン脂質中エイコサノイド前駆体脂肪酸含量に及ぼす影響2017

    • Author(s)
      道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K00848
  • [Presentation] ヒオデオキシコール酸の投与はTSODマウスの肝臓における炎症・線維化を促進する.2017

    • Author(s)
      渡辺志朗、藤田恭輔、西田建志、井村譲二、常山幸一
    • Organizer
      TSODマウス研究会情報交換会
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 防己黄耆湯のリトコール酸誘導胆汁うっ滞モデルマウスに対する改善効果.2017

    • Author(s)
      藤田恭輔, 渡辺志朗. 2017, 3, 24-27, 仙台
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] A mechanosensitive ion channel, TRPV4-methylation silencing in gastric epithelium2017

    • Author(s)
      Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama
    • Organizer
      Congress of the Asian Neurogastroenterology and Motility Association
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2017-03-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] ヒオデオキシコール酸のデキストラン硫酸ナトリウム誘発大腸炎に対する改善効果.2016

    • Author(s)
      藤田恭輔, 杉山和恵, 西川将司, 上田浩, 渡辺志朗.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] H. pylori infection directly induces methylation silencing of a gastric epithelial mechano-sensor, Transient Receptor Potential Vanilloid 4 in gastric epithelial cells2016

    • Author(s)
      Hiroshi Mihara, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Toshiro Sugiyama
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego, California United States of America
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] 脳虚血モデルマウスにみられる摂食障害に対するω3系脂肪酸の軽減効果2016

    • Author(s)
      道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K00848
  • [Presentation] Ursodeoxycholic acid suppresses lipogenesis and reduces lipid contents in mouse liver possibly by reducing β-muricholic acid, a farnesoid X receptor antagonist.2016

    • Author(s)
      Shiro Watanabe, Kyosuke Fujita
    • Organizer
      The first international symposium on Toyama-Asia-Africa Pharmaceutical network
    • Place of Presentation
      富山
    • Year and Date
      2016-09-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 脳虚血モデルマウスにみられる摂食障害に対するω3系脂肪酸の軽減効果2016

    • Author(s)
      道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
    • Organizer
      日本脂質栄養学会第25回大会
    • Place of Presentation
      秋田市にぎわい交流館AU(秋田市)
    • Year and Date
      2016-09-16
    • Data Source
      KAKENHI-PROJECT-15K00848
  • [Presentation] リトコール酸誘導胆汁うっ滞モデルマウスにおける肝傷害ならびに胆汁酸蓄積に対する防己黄耆湯の軽減効果.2016

    • Author(s)
      渡辺志朗、辻哲也、藤田恭輔
    • Organizer
      第33回和漢医薬学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-27
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 豚胆主要成分ヒオデオキシコール酸が肥満モデルマウスに与える影響2015

    • Author(s)
      藤田恭輔、常山幸一、辻 哲也、渡辺志朗
    • Organizer
      第32回和漢医薬学会学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2015-08-22
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 大柴胡湯の抗肥満作用に関する研究2015

    • Author(s)
      小西明伸、荒 哲也,山崎寛生、渡辺志朗、藤田恭輔
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] ヒオデオキシコール酸はTSODマウスにおける肝炎症反応を促進する2015

    • Author(s)
      藤田恭輔、常山幸一、渡辺志朗
    • Organizer
      第38回胆汁酸研究会
    • Place of Presentation
      横浜市
    • Year and Date
      2015-11-07
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 胆汁酸負荷による肝障害に対する防已黄耆湯の軽減効果2015

    • Author(s)
      渡辺志朗、藤田恭輔
    • Organizer
      第14回日本臨床中医薬学会学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2015-09-29
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] Gastrointestinal epithelia could be luminal sensors for chemical, hypo osmolality, acid, temperature and stretch via ATP release.2015

    • Author(s)
      Mihara Hiroshi, Sualeh Muhammad Jibran, Suzuki Nobuhiro, Tabuchi Yoshiaki, Sugiyama Toshiro
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] TSODマウスの肝炎に及ぼすヒオデオキシコール酸の効果2015

    • Author(s)
      藤田恭輔、常山幸一、渡辺志朗
    • Organizer
      日本薬学会北陸支部第127回例会
    • Place of Presentation
      富山市
    • Year and Date
      2015-11-15
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] マウスにおけるヒオデオキシコール酸とウルソデオキシコール酸の脂質低下作用の比較2014

    • Author(s)
      渡辺志朗,藤田恭輔
    • Organizer
      第36回胆汁酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-29
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 防已黄耆湯の胆汁酸誘発性肝障害抑制作用2013

    • Author(s)
      藤田恭輔、田中謙、能勢充彦、渡辺志朗
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] ケイヒのLC-MSによる網羅的成分分析と産地特有のマーカー化合物の同定2013

    • Author(s)
      田中謙、李峰、渡辺志朗、川原信夫
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 加味四物湯のサルコペニア(筋肉減少症)改善作用の検討(2)2013

    • Author(s)
      田邊宏樹、水野弘樹、井上未央里、森智一、中島健一、渡辺志朗、林忠紘、中島賢治、和田篤敬、井上誠
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Exogenous/endogenous substances detected in the plasma and brain after chitosan treatment in mice.2013

    • Author(s)
      牛一民、稲田千香子、趙キ、李峰、渡辺志朗、岡淳一郎、松本欣三
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Exogenous/endogenous substances detected in the plasma and brain after chitosan treatment in mice2013

    • Author(s)
      牛一民、稲田千香子、趙キ、李峰、渡辺志朗、岡淳一郎、松本欣三
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 加味四物湯のサルコペニア(筋肉減少症)改善作用の検討(2)2013

    • Author(s)
      田邊宏樹、水野弘樹、井上未央里、森智一、中島健一、渡辺志朗、林忠紘、中島賢治、和田篤敬、井上誠
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Phytochemical study on the root of Dipsacus asper, a Kampo medicine.2012

    • Author(s)
      李峰、渡辺志朗、手塚康弘、田中謙
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] コール酸/高脂肪添加食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012

    • Author(s)
      渡辺志朗
    • Organizer
      日本脂質栄養学会第21回大会
    • Place of Presentation
      麻布
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Eicosapentenoic acid supplementation attenuates hepatic accumulation of cholesterol esters but aggravates liver injury in mice fed a fatand sodium cholate-supplemented diet in mice2012

    • Author(s)
      Shiro Watanabe
    • Organizer
      The 1st International Conferecence on Pharma and Food
    • Place of Presentation
      Shizuoka
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Eicosapentenoic acid supplementation attenuates hepatic accumulation of cholesterol esters but aggravates liver injury in mice fed a fat- and sodium cholate-supplemented diet in mice2012

    • Author(s)
      Shiro Watanabe
    • Organizer
      The 1st International Conference on Pharma and Food
    • Place of Presentation
      Shizuoka
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 豚胆の脂質低下作用2012

    • Author(s)
      渡辺志朗、李峰、米山惇志、湖間戸俊輔
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-12
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Phytochemical study on the root of Dipsacus asper, a Kampo medicine2012

    • Author(s)
      李峰、渡辺志朗、手塚康弘、田中謙
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching-LC/MS/MS2012

    • Author(s)
      渡辺健一,石川千裕,桑原弘,佐藤公彦,小室勢津子,中川徹也,野村成章,矢吹昌司,渡辺志朗
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 胆汁酸添加高脂肪食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012

    • Author(s)
      渡辺志朗
    • Organizer
      胆汁酸研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-12-01
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 脂肪細胞でのトランス脂肪酸によるインスリン抵抗性に関する解析2011

    • Author(s)
      澤田啓介,根橋佳奈,大藏直樹,渡辺志朗,厚味厳一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 牛胆によって誘導される脂質代謝変化と脂肪性肝炎様症状における胆汁酸の役割,2011

    • Author(s)
      渡辺志朗
    • Organizer
      第33回胆汁酸研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 牛胆は一価不飽和脂肪酸含有コレステロールエステルの優位な蓄積を伴う脂肪肝を誘導する2011

    • Author(s)
      渡辺志朗,常山幸一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] トランス脂肪酸は脂肪細胞のインスリン応答性を低下させる2011

    • Author(s)
      大嶋利之、澤田啓介、根橋佳奈、大蔵直樹、渡辺志朗、厚味厳一
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 牛胆によって誘導される脂質代謝変化と脂肪性肝炎様症状における胆汁酸の役割2011

    • Author(s)
      渡辺志朗
    • Organizer
      第33回胆汁酸研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] エイコサペンタエン酸がコール酸添加高脂肪食により誘導される脂肪性肝炎様症状に及ぼす影響2011

    • Author(s)
      渡辺志朗、吉田康彦、湖間戸俊輔、浜田雄大、常山幸一
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 牛胆の投与によって誘導される脂肪性肝炎様症状に伴う脂質代謝変化の解析2011

    • Author(s)
      渡辺志朗
    • Organizer
      第12回Pharmaco-hematology Symposium
    • Place of Presentation
      富山
    • Year and Date
      2011-06-20
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] Chemical profiling of endogenous and exogenous markers of chitosan in an animal model of diabetes

    • Author(s)
      Niu Yimin, Li Feng, Hironori Fujiwara, Ken Tanaka, Shiro Watanabe, Sachie Sasak-Hamada, Jun-Ichiro Oka, Kinzo Matsumoto
    • Organizer
      第31回和漢医薬学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-08-30 – 2014-08-31
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] ヒオデオキシコール酸およびウルソデオキシコール酸の肝臓中トリグリセリド含量低下作用

    • Author(s)
      藤田恭輔、松川征也、井上俊、渡辺志朗
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] コール酸誘導性肝傷害および肝臓脂質代謝変動に対する防己黄耆湯の効果

    • Author(s)
      藤田恭輔、田中謙 、能勢充彦 、渡辺志朗
    • Organizer
      第35回胆汁酸研究会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590873
  • [Presentation] 大柴胡湯の抗肥満作用の検討

    • Author(s)
      林忠紘、荒哲也、和田篤敬、藤田恭輔、渡辺志朗
    • Organizer
      日本生薬学会第61年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 脂肪酸構成の網羅的分析によるコール酸誘発性肝障害とその防已黄耆湯による軽減の機構解析

    • Author(s)
      渡辺志朗,藤田恭輔
    • Organizer
      第31回和漢医薬学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-08-30 – 2014-08-31
    • Data Source
      KAKENHI-PROJECT-26460903
  • [Presentation] 豚胆の脂質低下作用における主要構成胆汁酸の役割

    • Author(s)
      渡辺志朗、藤田恭輔
    • Organizer
      第35回胆汁酸研究会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590873
  • 1.  TABUCHI Yoshiaki (20322109)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  TSUNEYAMA Koichi (10293341)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 3.  OKUYAMA Harumi (90080176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  IKEMOTO Atsushi (60295615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  HAMAZAKI Tomohito (70167592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Doshi Masaru (30392385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  Mihara Hiroshi (00612623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  NISHIZONO Hirofumi (10502289)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SUGIYAMA Toshiro (00196768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  TOMINAGA Makoto (90260041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  UCHIDA Kunitoshi (20581135)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KOIZUMI Schuichi (10280752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  藤田 恭輔 (70707538)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 14.  古澤 之裕 (80632306)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YAMAWAKI Hidemoto
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SUZUKI Nobuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  KOZAWA Toyomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  Fujinami Haruka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  ANDO Takayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 20.  NANJO Sohachi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 21.  Boudaka Ammar
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Muhammad Jibran Sualeh
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 23.  川口 甲介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  今中 常雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  下澤 伸行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  NAWAZ ALLAH
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  中川 崇
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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