OHDO Shigehiro 大戸茂弘

… Alternative Names

大戸茂弘オオドシゲヒロ

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Researcher Number	00223884
Other IDs
Affiliation (Current)	2024: 九州大学, 薬学研究院, 特命教授
Affiliation (based on the past Project Information) *help	2024: 九州大学, 薬学研究院, 特命教授 2021 – 2023: 九州大学, 薬学研究院, 教授 2016 – 2019: 九州大学, 薬学研究院, 教授 2011 – 2015: 九州大学, 薬学研究科(研究院), 教授 2008 – 2012: Kyushu University, 大学院・薬学研究院, 教授 … More 2011: 九州大学, 薬学研究院, 教授 2006 – 2007: 九州大学, 薬学研究院, 教授 2006: Kyushu University, Faculty of Pharmaceutical Sciences, Professor, 大学院薬学研究院, 教授 2005: KYUSHU UNIVERSITY, Faculty of Pharmaceutical Sciences, Prof., 大学院・薬学研究院, 教授 2004: 九州大学, 薬学研究院, 助教授 2001 – 2004: 九州大学, 大学院・薬学研究院, 助教授 2000: Graduate School of Pharmaceutical Sciences, KYUSHU UNIVERSITY Assistant Professor, 大学院・薬学研究院, 助手 1997 – 1999: 九州大学, 大学院・薬学研究科, 助手 1994: 九州大学, 大学院・薬学研究科, 助手 1993: 九州大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological Sciences / 応用薬理学・医療系薬学 / Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied pharmacology / Pharmaceutical Sciences and related fields / Complex systems Except Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Applied pharmacology
Keywords	Principal Investigator 生体リズム / 時計遺伝子 / 体内時計 / 時間薬理 / 時間薬理学 / 薬学 / 分子時計 / がん / Chronopharmacology / 細胞動態 … More / 薬物動態 / Biological clock / Biological rhythm / Biological Rhythm / 視交叉上核 / マウス / 創薬 / 時間治療 / 診断法 / 投薬タイミング / 骨髄抑制 / 制がん作用 / 細胞培養 / 細胞周期 / 制がん剤 / 標的臓器 / 遠隔操作 / 微弱電流刺激 / マクロファージ / 液性伝達時計 / 神経伝達時計 / 細胞伝達時計 / 環境適応 / システムバイオロジー / 環境応答 / ケミカルバイオロジ― / 時間生物学 / 炎症 / ケミカルバイオロジー / 時間生物 / 病態 / エキソソーム / Chronotherapy / Clock gene / Cancer / 発癌 / Chronopharmacokinetics / Suprachiasmatic Nuclei / Clock genes / 時間薬物動態学 / mouse / Suprachiasmatic nuclei / Interferon / Pharmacokinetics / 視交又上核 / インターフェロン / 金属元素 / 幹細胞 / 恒常性 / 腎障害 / 階層性 / 薬物移送 / 合併症 / 臓器障害 / 人工体内時計 / アポトーシス / 分化 / ベクター … More Except Principal Investigator HPLC / antitumor effect / adverse effect / cisplatin / adriamycin / docetaxel / chemotherapy / dosing schedule / circadian rhythm / melatonin / サーカディアンリズム / メラトニン / chronotherapy / 時間治療 / clinical marker / sleeping disorder / Fluorescence detection / sleeping / D-alanine / D-アラニン抗体 / 分析科学 / 睡眠時無呼吸症候群 / 4-キノロン / 概日リズム / 臨床マーカー / 睡眠障害 / 蛍光検出 / 睡眠 / D-アラニン / decetaxel / microanalysis / rhyrhm disturbance / blood sample / tailor-made medical treatment / テイラーメイド医療 / 微量分析 / リズム障害 / 血液試料 / テーラーメイド医療 / cancer chemotherapy / biological rhythm marker / irinotecan hydrochloride / 時計遺伝子 / ガン化学療法 / 生体リズムマーカー / 塩酸イリノテカン Less

細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyushu University
特定臓器の分子時計を標的かつ遠隔に操作する技術の開発と応用Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyushu University
Development of biological rhythm adjustment system through eyes for environmental adaptation by integrated analysis of molecule-cell-whole body focused on eyePrincipal Investigator
- Principal Investigator
  
  Shigehiro Ohdo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Kyushu University
Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biologyPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
The role of exosome on molecular clock in organ dysfunctionPrincipal Investigator
- Principal Investigator
  
  Ohdo Shigehiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
生体リズムの階層性を基盤にした薬物移送リズムとリズム調整因子の探索Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyushu University
Role of molecular clock on the homeostatic communication between each organ in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Ohdo Shigehiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
The molecular clock mechanism underlying the circadian rhythm of cellular metal level: interaction between molecular clock and cellular metalPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Role of molecular clock on the communication between each organ in organ dysfunctionPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesisPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
新種の抗癌剤創薬を指向した人工体内時計の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
時計遺伝子による癌関連遺伝子の転写制御を基盤にした癌診断法の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
体内時計の分子機構を基盤にしたがん診断法の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
時間制御型遺伝子発現ベクターの開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Development of dosing schedule based on molecular clock mechanismsPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Assessment of sleeping quality using integrated new chemical index derived from melatonin and D-alanine values
- Principal Investigator
  
  ZAITSU Kiyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular clock mechanism of cancerPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
Construction of optimal combined chemotherapy of anti-tumor drugs based on chronotherapy
- Principal Investigator
  
  HIGUCHI Shun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Study for cancer chronotherapy based on clock gene
- Principal Investigator
  
  HIGUCHI Shun
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
New approach to tailor-made medical treatment based on the ultra-sensitive assay of melatonin
- Principal Investigator
  
  ZAITSU Kiyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
Development of Chronotherapy Based on Clock GenesPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
Development of the mouse model with 24-hour rhythm disturbancesPrincipal Investigator
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
細胞周期と制がん剤の投薬のタイミング;時間薬理学的所見の機序解明Principal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
細胞周期と制がん剤の投薬のタイミングPrincipal Investigator
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University

[Journal Article] Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice.2022
- Author(s)
  Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: MCR-21-0786-E Issue: 6 Pages: 972-982
- DOI
  10.1158/1541-7786.mcr-21-0786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18249, KAKENHI-PROJECT-20K16306
[Journal Article] Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice2019
- Author(s)
  Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 11 Pages: 1921-1925
- DOI
  10.1248/bpb.b19-00546
- NAID
  130007740594
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972
[Journal Article] Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.2019
- Author(s)
  Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 519 Issue: 3 Pages: 613-619
- DOI
  10.1016/j.bbrc.2019.09.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972
[Journal Article] Microcurrent stimulation activates the circadian machinery in mice.2019
- Author(s)
  Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 513 Issue: 2 Pages: 292-299
- DOI
  10.1016/j.bbrc.2019.02.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18J20628
[Journal Article] Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.2018
- Author(s)
  Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 136 Issue: 4 Pages: 228-233
- DOI
  10.1016/j.jphs.2018.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17K16972
[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018
- Author(s)
  Katamune Chiharu、Koyanagi Satoru、Hashikawa Ken-ichi、Kusunose Naoki、Akamine Takahiro、Matsunaga Naoya、Ohdo Shigehiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 2 Pages: 547-558
- DOI
  10.1074/jbc.ra118.004942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system2018
- Author(s)
  Kimura Hinako、Matsunaga Naoya、Kakimoto Keisuke、Watanabe Miyako、Tsuruta Akito、Kusunose Naoki、Shiromizu Shoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 2 Pages: 1063-1069
- DOI
  10.1016/j.bbrc.2018.06.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.2018
- Author(s)
  Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8(1) Issue: 1 Pages: 9072-9072
- DOI
  10.1038/s41598-018-27280-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K19493, KAKENHI-PROJECT-18J11229
[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018
- Author(s)
  Akamine Takahiro、Kusunose Naoki、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 1 Pages: 181-187
- DOI
  10.1016/j.bbrc.2018.05.209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the antitumor effects of aldehyde dehydrogenase inhibitor.2018
- Author(s)
  Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
- Journal Title
  
  Cancer Res.
  
  Volume: 78(13) Issue: 13 Pages: 3698-3708
- DOI
  10.1158/0008-5472.can-17-4034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis2017
- Author(s)
  Hashikawa KI, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 9995-9995
- DOI
  10.1038/s41598-017-10599-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636
[Journal Article] Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.2017
- Author(s)
  Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 292 Issue: 52 Pages: 21397-21406
- DOI
  10.1074/jbc.m117.791285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.2016
- Author(s)
  Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291 Issue: 10 Pages: 4913-4927
- DOI
  10.1074/jbc.m115.696930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-25253038
[Journal Article] Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.2016
- Author(s)
  Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 291 Issue: 13 Pages: 7017-7028
- DOI
  10.1074/jbc.m115.713412
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19167, KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-26860097, KAKENHI-PROJECT-25253038
[Journal Article] Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.2016
- Author(s)
  S. Koyanagi, N. Kusunose, M. Taniguchi, T. Akamine, Y. Kanado, Y. Ozono, T. Masuda, Y. Kohro, N. Matsunaga, M. Tsuda, M. Salter, K. Inoue, and S. Ohdo.
- Journal Title
  
  Nat. Commun.
  
  Volume: 7 Issue: 1 Pages: 13102-13102
- DOI
  10.1038/ncomms13102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-15H02522, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H04765, KAKENHI-PROJECT-16K18885
[Journal Article] 体内時計の分子機構を基盤にした創薬・育薬2016
- Author(s)
  大戸茂弘
- Journal Title
  
  生体の科学
  
  Volume: 67（6） Pages: 574-578
- Data Source
  KAKENHI-PROJECT-15K15005
[Journal Article] Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.2016
- Author(s)
  Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.
- Journal Title
  
  J Biol Chem.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253038
[Journal Article] Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.2016
- Author(s)
  Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S
- Journal Title
  
  EBioMedicine
  
  Volume: 13 Pages: 262-273
- DOI
  10.1016/j.ebiom.2016.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H06795
[Journal Article] Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.2015
- Author(s)
  Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 87 Issue: 2 Pages: 314-322
- DOI
  10.1124/mol.114.094979
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Journal Article] 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is RegUlated by Molecular Clocks2014
- Author(s)
  Naoya Matsunaga, Kazufumi Itcho, Kengo Hamamura, Eriko Ikeda, Hisako Ikeyama, Yoko Furuichi, Miyako Watanabe, Satoru Koyanagi, Shigehiro Ohdo
- Journal Title
  
  Joumal of lnvestigative Dermatology
  
  Volume: (印刷中) Issue: 6 Pages: 1636-1644
- DOI
  10.1038/jid.2014.13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04175, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
[Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.2014
- Author(s)
  Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(36) Issue: 36 Pages: 25296-25305
- DOI
  10.1074/jbc.m114.577023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Journal Article] Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma2014
- Author(s)
  Okazaki, H., Matsunaga, N., Fujioka, T., Okazaki, F., Akagawa, Y., Tsurudome, Y., Ono, M,. Kuwano, M., Koyanagi, S., and Ohdo, S.
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Issue: 2 Pages: 543-551
- DOI
  10.1158/0008-5472.can-12-3241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650646, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
[Journal Article] Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.2014
- Author(s)
  Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 85 Issue: 5 Pages: 715-722
- DOI
  10.1124/mol.113.089805
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317
[Journal Article] Molecular mechanism regulating 24-hour rhythm of dopamine D3 receptor expression in mouse ventral striatum2013
- Author(s)
  Eriko Ikeda, Naoya Matsunaga, Keisuke Kakimoto, Kengo Hamamura, Akane Hayashi, Satoru Koyanagi, Shigehiro Ohdo
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 83 Issue: 5 Pages: 959-967
- DOI
  10.1124/mol.112.083535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04175, KAKENHI-PROJECT-23659084
[Journal Article] Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors2012
- Author(s)
  Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
- Journal Title
  
  Cancer Res
  
  Volume: 72(2) Pages: 395-401
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes2011
- Author(s)
  Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
- Journal Title
  
  Toxicology
  
  Volume: 280(3) Pages: 144-151
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Molecular basis of chronopharmaceutics2011
- Author(s)
  Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(9) Pages: 3560-3576
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice2010
- Author(s)
  Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.
- Journal Title
  
  Cancer Res
  
  Volume: 70(15) Pages: 6238-6246
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma2010
- Author(s)
  Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 113(4) Pages: 353-361
- NAID
  10027746067
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice2010
- Author(s)
  Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 333(3) Pages: 782-787
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Chronotherapeutic strategy : Rhythm monitoring, manipulation and disruption2010
- Author(s)
  Ohdo S.
- Journal Title
  
  Adv Drug Deliv Rev
  
  Volume: 62(9-10) Pages: 859-875
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Chronopharmacological strategies : Intraand inter-individual variability of molecular clock2010
- Author(s)
  Ohdo S, Koyanagi S, Matsunaga N.
- Journal Title
  
  Adv Drug Deliv Rev
  
  Volume: 62(9-10) Pages: 885-897
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene2009
- Author(s)
  Kim J, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 78(8) Pages: 1075-1082
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes : A possible mechanism of chemotherapy-induced circadian rhythm disturbances2008
- Author(s)
  Terazono, H., Hamdan, A., Matsunaga, N., Hayasaka, N., Kaji, H., Egawa, T., Makino, K., Shigeyoshi, Y., Koyanagi, S., Ohdo, S
- Journal Title
  
  Biochemical Pharmacology 75(8)
  
  Pages: 1616-1622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Journal Article] The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver (in press)2008
- Author(s)
  Matsunaga, N., Ikeda, M., Takiguchi, T., Koyanagi, S., Ohdo, S.
- Journal Title
  
  Hepatology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Journal Article] Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells2007
- Author(s)
  Takiguchi, T., Tomita, M., Matsunaga, N., Nakagawa, H., Koyanagi, S., Ohdo, S
- Journal Title
  
  Pharmacogenetics and Genomics 17(12)
  
  Pages: 1047-1056
- NAID
  130005024316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Journal Article] Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver2006
- Author(s)
  Koyanagi, S., Suyama, H., Kuramoto, Y., Matsunaga, N., Takane, H., Soeda, S., Shimeno, H., Higuchi, S., Ohdo, S
- Journal Title
  
  Endocrinology 147(11)
  
  Pages: 5034-5040
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Journal Article] Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice2006
- Author(s)
  Nakagawa, H., Takiguchi, T., Nakamura, M., Furuyama, A., Koyanagi, S., Aramaki, H., Higuchi, S., Ohdo, S
- Journal Title
  
  Biochemical Pharmacology 72(10)
  
  Pages: 1237-1245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Journal Article] Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice2005
- Author(s)
  Tabuchi M., To H., Sakaguchi H., Goto N., Takeuchi A., Higuchi S., Ohdo S.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 8448-8454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Journal Article] Chronotherapy of Adriamycin in Japanese Outpatients with Mammary Cancer2005
- Author(s)
  To H., Saito T., Ohdo S., Higuchi S., Fujimura A., Kobayashi E.
- Journal Title
  
  Drug in R&D 6
  
  Pages: 101-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Journal Article] Chronotherapy of Irinotecan.2005
- Author(s)
  Qin T, Goto N, To H, Tsuruta K, Ohdo S, Higuchi S.
- Journal Title
  
  The Japanese Journal of Therapeutic Drug Monitoring 22
  
  Pages: 171-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Presentation] がんの時間治療2016
- Author(s)
  大戸茂弘
- Organizer
  第37回日本臨床薬理学会
- Place of Presentation
  鳥取
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 患者にやさしい生体リズムにマッチした時間治療2016
- Author(s)
  大戸茂弘
- Organizer
  第49回日本漢方交流会　全国学術総会　福岡大会、特別講演
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] Chronopharmacology of antitumor drugs focused on biological clock 、Chronopharmacology in cancer, shift work sleep disorder and beyond2016
- Author(s)
  Shigehiro Ohdo
- Organizer
  SRBR 2016
- Place of Presentation
  USA(Florida)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 生体リズムを基盤にした創薬・育薬2016
- Author(s)
  大戸茂弘
- Organizer
  第33回日本TDM学会・学術大会、教育講演
- Place of Presentation
  栃木
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 時間薬理学を基盤にした創薬と育薬2016
- Author(s)
  大戸茂弘
- Organizer
  第23回日本時間生物学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2016-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 生体リズムを基盤にした創薬・育薬2016
- Author(s)
  大戸茂弘
- Organizer
  第64回質量分析総合討論会、特別講演
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] がんの時間薬理学を考えた効果的な緩和薬物治療2015
- Author(s)
  大戸茂弘
- Organizer
  第9回日本緩和医療薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 時間薬理学―患者さんにやさしい時間治療2015
- Author(s)
  大戸茂弘
- Organizer
  第26回日本緑内障学会
- Place of Presentation
  名古屋
- Year and Date
  2015-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 患者に優しい生体リズムにマッチしたクロノセラピィー2015
- Author(s)
  大戸茂弘
- Organizer
  第48回日本薬剤師会学術大会
- Place of Presentation
  鹿児島
- Year and Date
  2015-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] 時間制御による新たな創薬ストラテジ-2015
- Author(s)
  大戸茂弘
- Organizer
  日本薬剤学会創立30周年記念シンポジウム
- Place of Presentation
  長崎
- Year and Date
  2015-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K15005
[Presentation] Chronopharmacological aspects of transporters2013
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25253038
[Presentation] がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング.2013
- Author(s)
  大戸　茂弘　小柳　悟、松永　直哉
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-25136716
[Presentation] Chronopharmacological aspects of transporters2013
- Author(s)
  大戸　茂弘　小柳　悟、松永　直哉
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25670079
[Presentation] Chronopharmacological aspects of transporters2013
- Author(s)
  大戸　茂弘　小柳　悟、松永　直哉
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-25136716
[Presentation] がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング.2013
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25253038
[Presentation] がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング.2013
- Author(s)
  大戸　茂弘　小柳　悟、松永　直哉
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25670079
[Presentation] 時間薬理による副作用低減.シンポジウム「副作用低減のための新しい薬理学的アプローチ」(オーガナイザー:植田真一郎、大石了三)2011
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 分子時計を基盤にした時間治療.シンポジウム「生命現象を担う生体分子に着目した創薬と臨床応用」(オーガナイザー:荒牧弘範、前仲勝実)2011
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 分子時計を基盤にした創薬・育薬2010
- Author(s)
  大戸茂弘
- Organizer
  第5回DDS熊本シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2010-02-15
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 創薬・育薬を指向した時間薬剤学的研究2010
- Author(s)
  大戸茂弘
- Organizer
  特別講演第28回製剤設計研究会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 時間薬理学とは.シンポジウム「時間薬理学と時間栄養学による新しい治療戦略の開拓」(オーガナイザー:柴田重信、大戸茂弘)2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 癌の時間治療と今後の展望.シンポジウム「体内時計を利用した創薬から治療戦略まで」(オーガナイザー:柴田重信、守屋孝洋)2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 体内時計の分子機構を基盤にした薬物投与設計.シンポジウム1「薬物療法を支える基礎研究と臨床研究の糸口、進め方と成果の活用」(オーガナイザー:家入一郎、大戸茂弘)2010
- Author(s)
  小柳悟、松永直哉、大戸茂弘
- Organizer
  医療薬学フォーラム2010第18回クリニカルファーマシーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 創薬・育薬を指向した時間薬剤学的研究2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第47回薬剤学懇談会研究討論会「新技術・新素材が切り拓く薬剤開発」岐阜県飛騨高山
- Place of Presentation
  高山グリーンホテル、天領閣
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 抗がん剤の時間薬理.シンポジウム4「PK/PD解析から見た抗がん剤の効果・副作用」(オーガナイザー:鈴木洋史、桂敏也)2009
- Author(s)
  大戸茂弘、松永直哉、小柳悟
- Organizer
  医療薬学フォーラム2009第17回クリニカルファーマシーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] Molecular clock mechanisms of drug metabolism.2009
- Author(s)
  Ohdo S, Matsunaga N, Koyanagi S.
- Organizer
  Symposium"Functional genomics"16th International Conference on Cytochrome P450
- Place of Presentation
  Japan(Okinawa)
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 時間治療による薬物治療の最適化.特別講演2009
- Author(s)
  大戸茂弘
- Organizer
  第24回長崎DDS研究会
- Place of Presentation
  長崎
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 薬物・栄養投与の時間治療学的戦略～体内時計の分子機構を基盤として～.特別講演2009
- Author(s)
  大戸茂弘
- Organizer
  日本薬学会主催第10回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] Plenary lecture, Chronopharmacology of antitumor drugs : molecular clock mechanisms2007
- Author(s)
  Ohdo, S
- Organizer
  2nd World Congress of Chronobiology
- Place of Presentation
  Japan(Tokyo)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050
[Presentation] Chronopharmacology of antitumor drugs in mice2007
- Author(s)
  Ohdo, S
- Organizer
  The 3rd Asian Symposium for Pharmaceutical Sciences
- Place of Presentation
  Japan(Sasebo)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390050

1. HIGUCHI Shun (40218699)

# of Collaborated Projects: 10 results

# of Collaborated Products: 3 results
2. NAOYA Matsunaga (10432915)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
3. KOYANAGI Satoru (60330932)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
4. HAMASE Hamase (10284522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEZONO Keio (00168618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TO Hideto (90346809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. ZAITSU Kiyoshi (70091329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. FUKUOKA Hideoki (80111540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KANDA Taketoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MASUDA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 楠瀬直喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 桑野信彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 濱村賢吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 岡崎裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田原優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 柴田重信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 井上和秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 津田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OHDO Shigehiro 大戸 茂弘

大戸 茂弘 オオド シゲヒロ

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Co-Researchers

細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究Principal Investigator

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特定臓器の分子時計を標的かつ遠隔に操作する技術の開発と応用Principal Investigator

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Development of biological rhythm adjustment system through eyes for environmental adaptation by integrated analysis of molecule-cell-whole body focused on eyePrincipal Investigator

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Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biologyPrincipal Investigator

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The role of exosome on molecular clock in organ dysfunctionPrincipal Investigator

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生体リズムの階層性を基盤にした薬物移送リズムとリズム調整因子の探索Principal Investigator

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Role of molecular clock on the homeostatic communication between each organ in chronic kidney diseasePrincipal Investigator

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The molecular clock mechanism underlying the circadian rhythm of cellular metal level: interaction between molecular clock and cellular metalPrincipal Investigator

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Role of molecular clock on the communication between each organ in organ dysfunctionPrincipal Investigator

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Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesisPrincipal Investigator

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新種の抗癌剤創薬を指向した人工体内時計の開発Principal Investigator

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時計遺伝子による癌関連遺伝子の転写制御を基盤にした癌診断法の開発Principal Investigator

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体内時計の分子機構を基盤にしたがん診断法の開発Principal Investigator

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OHDO Shigehiro 大戸茂弘

大戸茂弘オオドシゲヒロ