HANAFUSA Tadashi 花房直志

Researcher Number	00228511
Affiliation (Current)	2020: 岡山大学, 中性子医療研究センター, 准教授
Affiliation (based on the past Project Information) *help	2016: 岡山大学, 自然生命科学研究支援センター, 准教授 2015: 岡山大学, 学内共同利用施設等, 准教授 2013 – 2014: 岡山大学, 自然生命科学研究支援センター, 准教授 2008 – 2011: 岡山大学, 自然生命科学研究支援センター, 助教 1991 – 2001: 岡山大学, アイソトープ総合センター, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Urology Except Principal Investigator Gastroenterology / Surgical dentistry / Laboratory medicine
Keywords	Principal Investigator HBV / 肝癌 / RLGS / ベクター / ゲノムメチレーション / リボザイム / アンチセンスDNA / 微分表示法 / 癌関連遺伝子 / HuH-7 … More Except Principal Investigator LOH / HCC / 肝細胞癌 / がん・精巣抗原 / SEREX / 抗体 / 腫瘍マーカー / がん抗原 / CT抗原 / 癌抑制遺伝子 / p53 / P53 / 癌遺伝子 / Hepatocellular carcinoma / RB / 多段階発癌 / RLGS / AP-PCR-SSCP / Teromerase / メチル化 / 抗原 / ELISA / リアルタイム / RT-PCR / 遺伝子 / DNAマイクロアレイ / リアルタイムRT-PCR / 血清 / 診断 / ウエスタンブロット / がん / SEREX法 / CCR4分子 / 制御制T細胞 / 腫瘍浸潤リンパ球 / 頭頸部癌 / CCR4 / PD-L1 / 制御性T細胞 / 抗体療法 / 肝炎ウイルス / 肝炎ウイルス遺伝子 / Tumor suppresser gene / HBV / HCV / RLGS法 / AP-PCR-SSCP法 / Ap-PCR-SSCP法 / PLGS法 / Hepatocellular carcinoma, / Tumor suppresser gene, / p53, / LOH, / RB, / HBV, / HCV, / RLGS, / AP-PCRSSCP / Hepatoma / APPCR-SSCP法 / 遺伝子異常 / Multi-step carcinogenesis / Methylation / 発癌 / 遺伝子発現異常 / cDNA microarray / IGFBP-3 / 癌部の遺伝子発現異常 / cDNA Microarray / IGFBP-3の発現低下 / IGFBP3 / methylation specific PC / microarray / Hepatocarcinogenesis / cDNA micro array / Reduced expression of the IGFBP-3 Less

Antitumor effect of anti-CCR4 antibody in head and neck cancer
- Principal Investigator
  
  DOMAE Shohei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagasaki University
  Okayama University
The development of serum diagnostic method applicable for the Japanese using cancer/testis antigens
- Principal Investigator
  
  DOMAE SHOHEI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
Induction of the tumor immune response by the dendritic cell targeting of the autoantigen mimotope.Principal Investigator
- Principal Investigator
  
  HANAFUSA Tadashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Okayama University
Development of tumor diagnosis method using cancer/testis antigens.
- Principal Investigator
  
  ONO Toshiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
THE STUDY OF GENE ABNORMALITIES RELATED TO HEPATOCELLULAR CARCINOMA
- Principal Investigator
  
  YUMOTO Yasuhiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  OKAYAMA UNIVERSITY
肝癌発癌初期過程に関与するゲノムのメチル化のRLGS法、RLCS法による解析Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
RLGS法、AP-PCR法を用いた肝癌染色体ゲノムの解析Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
RLGS法による肝癌染色体DNAの解析Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
THE STUDY OF ONCOGENE,TUMOR RERATED GENE RELATED TO HEPATOCELLULAR CARCINOMA AND HEPATITIS VIRUS GENE
- Principal Investigator
  
  YUMOTO Yasuhiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  OKAYAMA UNIVERSITY
遺伝子改変B型肝炎ウイルスのパッケージングと複製効率の改良Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
微分表示法による肝癌発癌に関与する癌関連遺伝子の検索Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
THE STUDY OF ONCOGENE,TUMOR SUPPRESSER GENE AND HEPATITIS VIRUS GENNES RELATED TO HEPATOCELLULAR CARCINOMA
- Principal Investigator
  
  YUMOTO Yasuhiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  OKAYAMA UNIVERSITY
肝炎の治療を目的とする遺伝子改変B型肝炎ウイルスの構築Principal Investigator
- Principal Investigator
  
  花房直志
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
THE STUDY OF ONCOGENE AND HEPATITIS VIRUS GENE RELATED TO HEPATOCELLULAR CARCINOMA
- Principal Investigator
  
  YUMOTO Yasuhiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  OKAYAMA UNIVERSITY

All 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity2012
- Author(s)
  Hanafusa T, Mohamed AE, Domae S, Nakayama E, Ono T
- Journal Title
  
  BMC Cancer
  
  Volume: 12 Pages: 520-520
- DOI
  10.1186/1471-2407-12-520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300332, KAKENHI-PROJECT-23792343
[Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2011
- Author(s)
  Hanafusa T.
- Journal Title
  
  Cancer Letters
  
  Volume: 301 Pages: 57-62
- NAID
  120003437013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659374
[Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies2011
- Author(s)
  T. Hanafusa, A. M. Ali Eldib, K. Kitaoka, Y. Ohue, E. Nakayama and T. Ono
- Journal Title
  
  Cancer Letters
  
  Volume: 301 Pages: 57-62
- NAID
  120003437013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590571
[Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies2011
- Author(s)
  Hanafusa T, Mohamed AE, Kitaoka K, Ohue Y, Nakayama E, Ono T
- Journal Title
  
  Cancer Letters
  
  Volume: 301 Pages: 57-62
- NAID
  120003437013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659374
[Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2011
- Author(s)
  T. Hanafusa, A.M. Ali Eldib, K. Kitaoka, Y. Ohue, E. Nakayama, T. Ono
- Journal Title
  
  Cancer Letters 301
  
  Pages: 57-62
- NAID
  120003437013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590571
[Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2011
- Author(s)
  Hanafusa, T.
- Journal Title
  
  Cancer Letters
  
  Volume: 301 Pages: 57-62
- NAID
  120003437013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity2012
- Author(s)
  花房直志, 銅前昇平, 小野俊朗
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Identification of GKAP1 as a novel cancer antigen and its immunogenicity in oral squamous cell carcinoma.2012
- Author(s)
  Domae S, Ono T, Hanafusa T, Yoshida S, Kishimoto K, Nakayama E, Sasaki A.
- Organizer
  21 Congress of the European Association for Cranio-Maxillo-Facial Surgery
- Place of Presentation
  Dubrovnik, Croatia
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity.2012
- Author(s)
  花房直志、銅前昇平、小野俊朗.
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Identification of GKAP1 as a novel cancer antigen and its immunogenicity in oral squamous cell carcinoma2012
- Author(s)
  Domae S, Ono T, Hanafusa T, Yoshida S, Kishimoto K, Nakayama E, Sasaki A
- Organizer
  21 Congress of the European Association for Cranio-Maxillo-Facial Surgery
- Place of Presentation
  Dubrovnik, Croatia
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Construction of phage scFv antibody against Protocadherin 11, a new tumor antigen candidate of prostate cancer2011
- Author(s)
  T. Hanafusa, S. Domae and T. Ono
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] 新規前立腺がん抗原プロトカドヘリン11に対するscFv抗体の作成2011
- Author(s)
  花房直志
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] 新規前立腺がん抗原プロトカドヘリン11に対するscFv抗体の作成2011
- Author(s)
  花房直志
- Organizer
  第70回に本願学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] SEREX同定抗原GKAP1に対する癌患者の液性免疫応答2011
- Author(s)
  銅前昇平, 花房直志, 大塚正人, 村岡美佳, 佐々木朗, 中山睿一, 小野俊朗
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Humoral immune response of cancer patients against newly SEREX-defined antigen,GKAP12011
- Author(s)
  銅前昇平, 花房直志, 大塚正人, 村岡美佳, 佐々木朗, 中山睿一, 小野俊朗
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23792343
[Presentation] Consruction of phage scFv antibody against Protocadherin 11, a new tumor antigen candidate of prostate cancer2011
- Author(s)
  T.Hanafusa
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Humoral immune response of cancer patients against newly SEREX-defined antigen2011
- Author(s)
  S. Domae, T. Hanafusa, M. Otsuka, M. Muraoka, A. Sasaki, E. Nakayama and T. Ono
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies2010
- Author(s)
  花房直志
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] SEREX法による肺腺癌抗原の同定と発現解析2010
- Author(s)
  花房直志
- Organizer
  第14回がん免疫学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] SEREX法による肺腺癌抗原の同定と発現解析2010
- Author(s)
  花房直志、北岡賢太、大植祥弘、中山睿一、小野俊朗
- Organizer
  第14回日本がん免疫学会総会
- Place of Presentation
  熊本市
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies2010
- Author(s)
  T. Hanafusa, K. Kitaoka, Y. Ohue, E. Nakayama and T. Ono
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2010
- Author(s)
  T.Hanafusa, K.Kitaoka, Y.Ohue, E.Nakayama, T.Ono
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies2010
- Author(s)
  花房直志
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] プロトカドヘリン11X/Y(PCDHl1X/Y)バリアントのがん細胞における発現様式2009
- Author(s)
  花房直志
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] プロトカドヘリン11 X/Y(PCDH11X/Y)バリアントのがん細胞における発現様式2009
- Author(s)
  花房直志
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21659374
[Presentation] Simultaneous expression of multiple splice variants of PCDH11X/Y in tumor cells.2009
- Author(s)
  T.Hanafusa, T.Ono, E.Nakayama
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20590571
[Presentation] Simultaneous expression of multiple splice variants of PCDH11X/Y in tumorcells2009
- Author(s)
  T. Hanafusa, T. Ono and E. Nakayama
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20590571

1. YUMOTO Yasuhiro (30033369)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. ONO Toshiro (50185641)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. DOMAE SHOHEI (70397892)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. KOIDE Norio (20142333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIGASHI Toshihiro (80173136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. UENAKA Akiko (50273967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NOUSO Kazuhisa (10314668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 榮川伸吾 (40635265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUNISADA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKAKURA Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中山睿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HANAFUSA Tadashi 花房 直志

Research Projects

Research Products

Co-Researchers

Antitumor effect of anti-CCR4 antibody in head and neck cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of serum diagnostic method applicable for the Japanese using cancer/testis antigens

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of the tumor immune response by the dendritic cell targeting of the autoantigen mimotope.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of tumor diagnosis method using cancer/testis antigens.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE STUDY OF GENE ABNORMALITIES RELATED TO HEPATOCELLULAR CARCINOMA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝癌発癌初期過程に関与するゲノムのメチル化のRLGS法、RLCS法による解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RLGS法、AP-PCR法を用いた肝癌染色体ゲノムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RLGS法による肝癌染色体DNAの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE STUDY OF ONCOGENE,TUMOR RERATED GENE RELATED TO HEPATOCELLULAR CARCINOMA AND HEPATITIS VIRUS GENE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子改変B型肝炎ウイルスのパッケージングと複製効率の改良Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

微分表示法による肝癌発癌に関与する癌関連遺伝子の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE STUDY OF ONCOGENE,TUMOR SUPPRESSER GENE AND HEPATITIS VIRUS GENNES RELATED TO HEPATOCELLULAR CARCINOMA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝炎の治療を目的とする遺伝子改変B型肝炎ウイルスの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

HANAFUSA Tadashi 花房直志