ohkura kazuto 大倉一人

… Alternative Names

OHKURA Kazuto 大倉一人

OHKURA kazuo 大倉一人

大倉一人オオクラカズト

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Researcher Number	00242850
Other IDs
Affiliation (Current)	2025: 鈴鹿医療科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2023: 鈴鹿医療科学大学, 薬学部, 教授 1999 – 2005: Nagoya University, Bioagricultural Sciences, Nagoya University, Assistant Professor, 大学院・生命農学研究科, 助手 1997 – 1998: 名古屋大学, 農学部, 助手 1993: 名古屋大学, 農学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 医薬分子機能学 / Medical pharmacy / Drug development chemistry Except Principal Investigator Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 感染症 / 細胞溶解毒素 / 細菌感染症 / 生体膜 / cytolysin / infection / 細胞膜 / 相互作用 / タンパク毒素 / targeting … More / コレステロール / ターゲッティング / hormonal action / cell differentiation / molecular design / Cell / Membrane / Insulin / ホルモン作用 / 細胞分化 / 分子設計 / ヒト特異的 / タンパク質毒素 … More Except Principal Investigator アンギノーサス / 溶血毒素 / 病原性 / レンサ球菌 / ストレプトリジンS / 細胞増殖促進 / 細胞膜安定化 / インスリン作用増強効果 / 酸性サブユニット / 大豆グリシニン Less

Molecular characteristics specific for streptolysin S produced by human opportunistic Anginosus group streptococci
- Principal Investigator
  
  田端厚之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The University of Tokushima
Structural and functional analysis of cytotoxic factors derived from pathogenic streptococci and their application to infection controlPrincipal Investigator
- Principal Investigator
  
  Ohkura Kazuto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Suzuka University of Medical Science
Functional analysis of streptococcal toxinsPrincipal Investigator
- Principal Investigator
  
  OHKURA Kazuto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Suzuka University of Medical Science
Functional analysis of streptolysin S involved factorsPrincipal Investigator
- Principal Investigator
  
  Ohkura Kazuto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Suzuka University of Medical Science
Molecular analysis of streptococcus derived protein factors for application to drug discoveryPrincipal Investigator
- Principal Investigator
  
  OHKURA Kazuto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Suzuka University of Medical Science
Dynamic structure of intermedilysin : Analysis of membrane binding regionPrincipal Investigator
- Principal Investigator
  
  OHKURA Kazuto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya University
Analysis of Intermedilysin in Human Specific Cytolytic Mechanism : Design and Application for Cell Targeting Module.Principal Investigator
- Principal Investigator
  
  OHKURA Kazuto
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nagoya University
Analysis of Structural Similarity of Molecular Dynamics Application for the Induction of Cell DifferentiationPrincipal Investigator
- Principal Investigator
  
  OHKURA kazuo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  NAGOYA UNVERSITY
大豆グリシニンのインスリン作用増強効果
- Principal Investigator
  
  牧野志雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2005 2004 Other

All Journal Article Presentation

[Journal Article] Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors2023
- Author(s)
  Takuya Yamada、Yugo Yamamori、Nanami Matsuda、Hideaki Nagamune、Kazuto Ohkura、Toshifumi Tomoyasu、Atsushi Tabata
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13720-13720
- DOI
  10.1038/s41598-023-40981-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09139, KAKENHI-PROJECT-21K06655
[Journal Article] Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S-producing streptococci.2023
- Author(s)
  Yokohata S, Ohkura K, Nagamune H, Tomoyasu T, Tabata A.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 67 Issue: 2 Pages: 58-68
- DOI
  10.1111/1348-0421.13042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06655, KAKENHI-PROJECT-20K09919
[Journal Article] Molecular Aspects of C-glycosides: Interactive Analysis of C-linked Compounds With the SGLT2 Molecular Model2023
- Author(s)
  Kazuto Ohkura, Atsushi Tabata
- Journal Title
  
  Anticancer Res
  
  Volume: 43 Issue: 8 Pages: 3747-3754
- DOI
  10.21873/anticanres.16559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06655
[Journal Article] Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.2022
- Author(s)
  Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.
- Journal Title
  
  J Oral Microbiol.
  
  Volume: 14 Issue: 1 Pages: 2105013-2105013
- DOI
  10.1080/20002297.2022.2105013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06655, KAKENHI-PROJECT-20K09919
[Journal Article] Molecular Interaction Between Boron Tracedrug UTX-51 Derivatives and Bovine Serum Albumin: Application to an Analytical Model of AGEs Destruction by Thermal Neutron Irradiation.2022
- Author(s)
  Ohkura K, Tabata A, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 42 Issue: 8 Pages: 4017-4023
- DOI
  10.21873/anticanres.15898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06655, KAKENHI-PROJECT-20K09919
[Journal Article] Construction of a drug release evaluation system: application of mitochondrial respiration to monitor drug release2021
- Author(s)
  Kazuto Ohkura, Yohei Tatematsu, Atsushi Tabata
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 8 Pages: 4083-4088
- DOI
  10.21873/anticanres.15210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09919, KAKENHI-PROJECT-21K06655
[Journal Article] Molecular characteristics of an adhesion molecule containing cholesterol‐dependent cytolysin‐motif produced by mitis group streptococci2021
- Author(s)
  Matsumoto Airi、Tabata Atsushi、Ohkura Kazuto、Oda Hiroki、Kodama Chihiro、Ohkuni Hisashi、Takao Ayuko、Kikuchi Ken、Tomoyasu Toshifumi、Nagamune Hideaki
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 65 Issue: 2 Pages: 61-75
- DOI
  10.1111/1348-0421.12868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09919, KAKENHI-PROJECT-18K06764, KAKENHI-PROJECT-18K09552, KAKENHI-PROJECT-21K06655
[Journal Article] Effect of Isomerization of TX-2036 Derivatives on the Interaction With Tyrosine Kinase Domain of EGF Receptor2020
- Author(s)
  OHKURA KAZUTO、TABATA ATSUSHI、UTO YOSHIHIRO、HORI HITOSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 8 Pages: 4675-4680
- DOI
  10.21873/anticanres.14466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764
[Journal Article] Effect of isomerization of TX-2036 derivatives on the interaction with tyrosine kinase domain of EGF receptor.2020
- Author(s)
  Ohkura K, Tabata A, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764
[Journal Article] Correlation Between Radiosensitizing Activity and the Stereo-structure of the TX-2036 Series of Molecules.2019
- Author(s)
  Ohkura K, Tabata A, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 39 Issue: 8 Pages: 4479-4483
- DOI
  10.21873/anticanres.13622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764, KAKENHI-PROJECT-17K10480
[Journal Article] β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro2019
- Author(s)
  Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H.
- Journal Title
  
  Journal of Oral Microbiology
  
  Volume: in press
- NAID
  120006711364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764
[Journal Article] Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation.2018
- Author(s)
  Ohkura K, Kawaguchi Y, Tatematsu Y, Tabata A, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 38 Issue: 7 Pages: 4241-4245
- DOI
  10.21873/anticanres.12720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764
[Journal Article] Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib on Mitochondrial Function.2018
- Author(s)
  Tatematsu Y, Fujita H, Hayashi H, Yamamoto A, Tabata A, Nagamune H, Ohkura K.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 41 Pages: 319-325
- NAID
  130006407351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.2017
- Author(s)
  Ohkura K, Tatematsu Y, Kawaguchi Y, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 3849-3854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase2016
- Author(s)
  Kazuto Ohkura, Yuki Kawaguchi, Yohei Tatematsu, Yoshihiro Uto, Hitoshi Hori
- Journal Title
  
  Anticancer Res.
  
  Volume: 36 Pages: 3645-3649
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] Effect of <i>N</i>-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition2016
- Author(s)
  Yohei Tatematsu, Hiroki Hayashi, Ryo Taguchi, Haruhi Fujita, Atsushi Yamamoto, Kazuto Ohkura
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 2 Pages: 278-284
- DOI
  10.1248/bpb.b15-00717
- NAID
  130005122365
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH-insensitive Inhibitory Effects on the Mitochondrial ADP/ATP Carrier2015
- Author(s)
  Atsushi Yamamoto, Keisuke Hasui, Hiroshi Matsuo, Katsuhiro Okuda, Masato Abe, Kenji Matsumoto, Kazuki Harada, Yuya Yoshimura, Takenori Yamamoto, Kazuto Ohkura, Mitsuru Shindo, Yasuo Shinohara
- Journal Title
  
  Chem. Biol. Drug Des.
  
  Volume: 86 Issue: 5 Pages: 1304-1322
- DOI
  10.1111/cbdd.12594
- NAID
  120006732016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08113, KAKENHI-PROJECT-26450139, KAKENHI-PROJECT-26460069, KAKENHI-PROJECT-25460066, KAKENHI-PROJECT-26670003, KAKENHI-PROJECT-26293004
[Journal Article] Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems2015
- Author(s)
  Atsushi Tabata, Yukimasa Ohkubo, Natsuki Anyoji, Keiko Hojo, Toshifumi Tomoyasu, Yohei Tatematsu, Kazuto Ohkura, Hideaki Nagamune
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 4411-4417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] Immunoblotting with Peptide Antibodies: Differential Immunoreactivities Caused by Certain Amino Acid Substitutions in a Short Peptide and Possible Effects of Differential Refolding of the Peptide on a Nitrocellulose or PVDF Membrane2015
- Author(s)
  Takenori Yamamoto, Taisuke Matsuo, Atsushi Yamamoto, Ryohei Yamagoshi, Kazuto Ohkura, Masatoshi Kataoka, Yasuo Shinohara
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1348 Pages: 303-310
- DOI
  10.1007/978-1-4939-2999-3_26
- ISBN
  9781493929986, 9781493929993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08113, KAKENHI-PROJECT-26460069, KAKENHI-PROJECT-25460066
[Journal Article] Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity2015
- Author(s)
  Yuki Kawaguchi, Yohei Tatematsu, Atsushi Tabata, Hideaki Nagamune, Kazuto Ohkura
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 4515-4519
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08113
[Journal Article] A streptolysin S homologue is essential for β-haemolytic Streptococcus constellatus subsp. constellatus cytotoxicity2014
- Author(s)
  Atsushi Tabata, Yuji Sato, Kentaro Maya, Kota Nakano, Ken Kikuchi, Robert Whiley, Kazuto Ohkura, Toshifumi Tomoyasu, Hideaki Nagamune
- Journal Title
  
  Microbiology
  
  Volume: 160 Issue: 5 Pages: 980-991
- DOI
  10.1099/mic.0.075580-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221, KAKENHI-PROJECT-24590536, KAKENHI-PROJECT-25861746
[Journal Article] Utility of syntenic relationships of VDAC1 pseudogenes for not only an understanding of the phylogenetic divergence history of rodents, but also ascertaining possible pseudogene candidates as genuine pseudogenes2014
- Author(s)
  Yusuke Ido, Tatsuki Yoshitomi, Kazuto Ohkura, Takenori Yamamoto, Yasuo Shinohara
- Journal Title
  
  Genomics
  
  Volume: 104 Issue: 2 Pages: 128-133
- DOI
  10.1016/j.ygeno.2014.05.003
- NAID
  120006763928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221, KAKENHI-PROJECT-25460066, KAKENHI-PROJECT-26460069
[Journal Article] The diversity of receptor recognition in cholesterol-dependent cytolysins2014
- Author(s)
  Atsushi Tabata, Kazuto Ohkura, Yukimasa Ohkubo, Toshifumi Tomoyasu, Hisashi Ohkuni, Robert Whiley, Hideaki Nagamune
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 58 Issue: 3 Pages: 155-171
- DOI
  10.1111/1348-0421.12131
- NAID
  40020034557
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590221, KAKENHI-PROJECT-24592769
[Journal Article] Comparison of the Catalytic Activities of Three Isozymes of Carnitine Palmitoyltransferase 1 Expressed in COS7 Cells2014
- Author(s)
  Takuya Hada, Takenori Yamamoto, Atsushi Yamamoto, Kazuto Ohkura, Naoshi Yamazaki, Yoshiharu Takiguchi, Yasuo Shinohara
- Journal Title
  
  Appl Biochem Biotechnol
  
  Volume: 172 Issue: 3 Pages: 1486-1496
- DOI
  10.1007/s12010-013-0619-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221, KAKENHI-PROJECT-25460066
[Journal Article] Molecular analysis of Streptococcus anginosus-derived SagA peptides2014
- Author(s)
  Yuki Kawaguchi, Atsushi Tabata, Hideaki Nagamune, Kazuto Ohkura
- Journal Title
  
  Anticancer Research
  
  Volume: 34 Pages: 4627-4631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221
[Journal Article] Novel twin streptolysin S-like peptides encoded in the sag operon homologue of β-hemolytic Streptococcus anginosus2013
- Author(s)
  Atsushi Tabata, Kota Nakano, Kazuto Ohkura, Toshifumi Tomoyasu, Ken Kikuchi, Robert Whiley, Hideaki Nagamune
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 195 Issue: 5 Pages: 1090-1099
- DOI
  10.1128/jb.01344-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221, KAKENHI-PROJECT-24590536
[Journal Article] Profiles of ILY, VLY and Sm-hPAF interaction with human CD592013
- Author(s)
  Yuki Kawaguchi, Atsushi Tabata, Hideaki Nagamune, Kazuto Ohkura
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 2901-2904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221
[Journal Article] Construction of Improved Drug-delivery System Tool with Enhanced Versatility in Cell-Targeting2013
- Author(s)
  Atsushi abata, Yukimasa Ohkubo, Masato Tamura, Toshifumi Tomoyasu, Kazuto Ohkura, Hideaki Nagamune
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 2905-2910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221
[Journal Article] Molecular profiles of cholesterol-dependent cytolysin family-derived 11mer regions2012
- Author(s)
  Kazuto Ohkura, Yuki Kawaguchi, Atsushi Tabata, Atsushi Yamamoto, Yasuo Shinohara, Hideaki Nagamune, Hitoshi Hori
- Journal Title
  
  Anticancer Research
  
  Volume: 32 Pages: 2343-2346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221
[Journal Article] Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool2012
- Author(s)
  Atsushi Tabata, Yukimasa Ohkubo, Eriko Sakakura, Toshifumi Tomoyasu, Kazuto Ohkura, Hideaki Nagamune
- Journal Title
  
  Anticancer Research
  
  Volume: 32 Pages: 2323-2329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590221
[Journal Article] Bridge-linked Bis-quaternary Ammonium Antimicrobial Agents : Relationship between Cytotoxicity and Antibacterial Activity of 5,5'-[2,2'-(tetramethylenedicarbonyldioxy)diethyl]bis(3-alkyl-4-methylthiazonium iodide)s2005
- Author(s)
  Kazuto Ohkura, Akiko Sukeno, Hideaki Nagamune, Hiroki Kourai
- Journal Title
  
  Bioorganic and Medicinal Chemistry Vol.13-No.7
  
  Pages: 2579-2587
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Bridge-linked Bis-quaternary Ammonium Antimicrobial Agents : Relationship between Cytotoxicity and Antibacterial Activity of 5,5'-〔2,2'-(tetramethylenedicarbonyldioxy)diethyl〕bis(3-alkyl-4-methylthiazonium iodide)s2005
- Author(s)
  Kazuto Ohkura
- Journal Title
  
  Bioorganic and medicinal Chemistry 13・7
  
  Pages: 2579-2587
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Bridge-linked Bis-quaternary Ammonium Antimicrobial Agents : Relationship between Cytotoxicity and Antibacterial Activity of 5,5'-[2,2'-(tetramethylenedicarbonyldioxy) diethyl]bis(3-alkyl-4-methylthiazonium iodide)s.2005
- Author(s)
  Ohkura, K.
- Journal Title
  
  Bioorg.Med.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Molecular Basis of Group A Streptococcal Pyrogenic Exotoxin B2005
- Author(s)
  Hideaki Nagamune, Kazuto Ohkura, Hisashi Ohkuni
- Journal Title
  
  Journal of Infection and Chemotherapy Vol.11-No.1
  
  Pages: 1-8
- NAID
  10014469726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Intermedilysin is Essential for the Invasion of Hepatoma HepG2 cells by Streptococcus intermedius2005
- Author(s)
  Akiko Sukeno, Hideaki Nagamune, Robert A.Whiley, Syed I.Jafar, Joseph Aduse-Opoku, Kazuto Ohkura, Takuya Maeda, Katsuhiko Hirota, Yoichiro Miyake, Hiroki Kourai
- Journal Title
  
  Microbiology and Immunology Vol.49-No.7
  
  Pages: 681-694
- NAID
  10016568016
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Bridge-linked Bis-quaternary Ammonium Antimicrobial Agents : Relationship between Cytotoxicity and Antibacterial Activity of 5,5'-[2,2'-(tetramethylenedicarbonyldioxy) diethyl]bis(3-alkyl-4-methylthiazonium iodide)s2005
- Author(s)
  Kazuto Ohkura
- Journal Title
  
  Bioorganic and Medicinal Chemistry 13・7
  
  Pages: 2579-2587
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Structural Analysis of Human Specific Cytolysin Intermedilysin aiming Application to Cancer Immunotherapy2004
- Author(s)
  Kazuto Ohkura, Hideaki Nagamune, Hiroki Kourai
- Journal Title
  
  Anticancer Research Vol.24-No.5C
  
  Pages: 3343-3354
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] Structural Analysis of Human Specific Cytolysin Intermedilysin aiming Application to Cancer Immunotherapy2004
- Author(s)
  Kazuto Ohkura
- Journal Title
  
  Anticancer Research 24・5
  
  Pages: 3343-3354
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] The Human-specific Action of Intermedilysin, a Homologue of Streptolysin O, is Dictated by Domain 4 of the Protein2004
- Author(s)
  Hideaki Nagamune, Kazuto Ohkura, Akiko Sukeno, Graeme Cowan, Timothy J.Mitchell, Wataru Ito, Ooki Ohnishi, Kanako Hattori, Miki Yamato, Katsuhiko Hirota, Yoichiro Miyake, Takuya Maeda, Hiroki Kourai
- Journal Title
  
  Microbiology and Immunology Vol.48-No.9
  
  Pages: 677-692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Journal Article] A Cell Membrane Modification Technique using Domain 4 of Intermedilysin for Immunotherapy against Cancer2004
- Author(s)
  Hideaki Nagamune, Kazuto Ohkura, Kazunori Umezu, Hidekatsu Shoji, Hiroki Kourai
- Journal Title
  
  Anticancer Research Vol.24-No.5C
  
  Pages: 3367-3372
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590098
[Presentation] ペプチド溶血毒素ストレプトリジンSの血液成分による安定化と病原性への寄与2023
- Author(s)
  田端厚之、横畑修人、大倉一人、友安俊文、長宗秀明
- Organizer
  第53回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-23K09139
[Presentation] ヒト血清アルブミンによるStreptolysin Sの細胞傷害活性の安定化2023
- Author(s)
  横畑修人、大倉一人、長宗秀明、友安俊文、田端厚之
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] UTX-114ファミリーとEGFR-tykとの相互作用解析：アセチルグルコース付加によるゲフィチニブ機能の修飾2023
- Author(s)
  田端厚之、宇都義浩、大倉一人
- Organizer
  第27回バイオ治療法学会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] レンサ球菌が産生するペプチド溶血毒素ストレプトリジンSの血清アルブミンによる活性保護2023
- Author(s)
  田端厚之、横畑修人、大倉一人、友安俊文、長宗秀明
- Organizer
  第69回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-23K09139
[Presentation] ペプチド溶血毒素ストレプトリジンSの血液成分による安定化と病原性への寄与2023
- Author(s)
  田端厚之、横畑修人、大倉一人、友安俊文、長宗秀明
- Organizer
  第53回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] レンサ球菌が産生するペプチド溶血毒素ストレプトリジンSの血清アルブミンによる活性保護2023
- Author(s)
  田端厚之，横畑修人，大倉一人，友安俊文，長宗秀明
- Organizer
  第69回毒素（トキシン）シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] Characterization of the third type of cholesterol-dependent cytolysins produced from Streptococcus mitis strains2022
- Author(s)
  Atsushi Tabata, Airi Matsumoto, Ai Fujimoto, Takuya Ikeda, Kazuto Ohkura, Toshifumi Tomoyasu, Ayuko Takao, Hisashi Ohkuni, Hideaki Nagamune
- Organizer
  21st Lancefield International Symposium on Streptococci and Streptococcal Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] ミティス群レンサ球菌が産生するコレステロール依存性細胞溶解毒素様の細胞接着分子の特性2022
- Author(s)
  松本愛理、田端厚之、大倉一人、尾田優紀、児玉千紘、大國寿士、高尾亞由子、菊池賢、友安俊文、長宗秀明
- Organizer
  第６回鹿大細菌カンファレンス
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] C-配糖体型SGLT2阻害剤の分子特性：ヒトSGLT2分子モデルとの相互作用解析2022
- Author(s)
  田端厚之、大倉一人
- Organizer
  第26回日本バイオ治療法学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] ミチス群レンサ球菌が産生するコレステロール依存性細胞溶解毒素モチーフを持つ細胞接着分子の特性2021
- Author(s)
  松本愛理、田端厚之、大倉一人、児玉千紘、大國寿士、高尾亞由子、菊池賢、友安俊文、長宗秀明
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] UTX-51誘導体とモデル標的タンパク質との相互作用：中性子照射による終末糖化産物破壊に寄与するボロントレース化合物の開発2021
- Author(s)
  田端厚之、宇都義浩、大倉一人
- Organizer
  第25回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] ミチス群レンサ球菌が産生するコレステロール依存性細胞溶解毒素モチーフを持つ細胞接着分子の特性2021
- Author(s)
  松本愛理、田端厚之、大倉一人、児玉千紘、大國寿士、高尾亞由子、菊池賢、友安俊文、長宗秀明
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K06655
[Presentation] リアルタイム薬剤検出システムの構築試行：ミトコンドリア酸素消費速度を利用した担体からの薬剤放出特性の解析2020
- Author(s)
  田端厚之、立松洋平、大倉一人
- Organizer
  第24回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] 脂肪酸結合タンパク質（FABP）のアイソフォーム間における薬物結合能の比較2019
- Author(s)
  山本篤司、服部奈々美、江口昂佑、田口裕基、刀根淳貴、大倉一人
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] Chiral-2-nitroimidazole骨格を足場としたTX-2036誘導体の特性：EGF受容体キナーゼドメインとの相互作用2019
- Author(s)
  田端厚之、宇都義浩、堀　均、大倉一人
- Organizer
  第23回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] Chiral-2-nitroimidazole骨格を有するTX-2036誘導体の開発：放射線増感能の修飾に関わる分子特性の検証2018
- Author(s)
  田端厚之、宇都義浩、堀　均、大倉一人
- Organizer
  第22回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] 非ステロイド性抗炎症薬セレコキシブの細胞膜障害メカニズムの解析2018
- Author(s)
  立松洋平、田端厚之、長宗秀明、大倉一人
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 薬剤キャリアのミセルが示す癌細胞障害性2018
- Author(s)
  西平有里菜、田端厚之、友安俊文、大倉一人、長宗秀明
- Organizer
  第22回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-18K06764
[Presentation] Positive and negative control mechanisms of pathogenicity expression in Streptococcus intermedius2017
- Author(s)
  Toshifumi Tomoyasu, Atsushi Tabata, Shinya Chiba, Takahiro Yamasaki, Shingo Kusaka, Nozomi Takeda, Masaaki Tamaoka, Kazuto Ohkura, Robert A Whiley, Hideaki Nagamune
- Organizer
  Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 蛍光物質との競合反応を利用した肝型脂肪酸結合タンパク質に結合する薬物の探索とその特徴解析2017
- Author(s)
  山本篤司、立松洋平、篠原康雄、大倉一人
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 非ステロイド性抗炎症薬のStreptococcus intermedius由来細胞溶解毒素活性に及ぼす影響2017
- Author(s)
  立松洋平、田端厚之、長宗秀明、大倉一人
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 糖付加によるTX-1877系列化合物の機能制御：放射線増感能との相関解析2017
- Author(s)
  立松洋平、川口遊喜、田端厚之、宇都義浩、堀均、大倉一人
- Organizer
  第21回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 糖による Streptococcus intermedius の病原性制御機構2017
- Author(s)
  友安俊文、田端厚之、千葉真也、山崎貴大、竹田望、玉岡雅章、大倉一人、長宗秀明
- Organizer
  第64回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] フェナム酸系非ステロイド性抗炎症薬のミトコンドリア透過性遷移誘導機構の解明2016
- Author(s)
  立松洋平、林　大輝、田口　諒、藤田明日、山本篤司、大倉一人
- Organizer
  日本薬学会136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] COX-2阻害能を持たせた2-Hydroxyarylidene-4-cyclopentene-1,3-dione誘導体の分子設計：TX-1123とCOX-2との相互作用解析2016
- Author(s)
  立松洋平、川口遊喜、宇都義浩、佐藤利夫、堀均、大倉一人
- Organizer
  第20回バイオ治療法研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] ヒト特異的な細胞障害性を示す細菌毒素に対する糖の阻害作用2016
- Author(s)
  田端厚之、大倉一人、立松洋平、友安俊文、長宗秀明
- Organizer
  第20回バイオ治療法研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] 2-Hydroxyarylidene-4- cyclopentene-1,3-dione誘導体の機能解析：Src-Kとの相互作用2015
- Author(s)
  立松洋平、川口遊喜、宇都義浩、堀　均、大倉一人
- Organizer
  第19回バイオ治療法研究会
- Place of Presentation
  東京
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] Inhibitory effects of the bongkrekic acid analogues on the mitochondrial ADP/ATP carrier2015
- Author(s)
  山本篤司、奥田勝博、安部真人、松本健司、山本武範、大倉一人、寺田弘、新藤充、篠原康雄
- Organizer
  第43回構造相関シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-09-27
- Data Source
  KAKENHI-PROJECT-15K08113
[Presentation] メフェナム酸類縁体によるミトコンドリア透過性遷移の誘導とその構造特性2014
- Author(s)
  山本篤司、林大輝、立松洋平、藤田明日、大倉一人
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] 3つのVDAC1の偽遺伝子はラットとマウスの分岐前に形成されていた2014
- Author(s)
  井戸佑介、吉冨立樹、大倉一人、山本武範、篠原康雄
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] アミノ酸挿入によるCT活性の消失：天然型抗凝固薬のX因子結合特性を指標としたアナログ分子の探索2014
- Author(s)
  立松洋平、川口遊喜、田端厚之、長宗秀明、大倉一人
- Organizer
  第18回バイオ治療法研究会
- Place of Presentation
  高松
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] ドラッグデリバリーシステム創成を目指したSortase Aによるペプチド修飾化リポソーム作製技術の開発2014
- Author(s)
  大久保行将、安養寺夏希、田端厚之、北條恵子、友安俊文、立松洋平、大倉一人、長宗秀明
- Organizer
  第18回バイオ治療法研究会
- Place of Presentation
  高松
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] Streptococcus anginosus由来ストレプトリジンSホモログの分子内環形成による活性制御2013
- Author(s)
  大倉一人、川口遊喜、田端厚之、長宗秀明
- Organizer
  第17回バイオ治療法研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] 種々の非ステロイド性抗炎症薬により誘起されるミトコンドリア透過性遷移の比較解析2013
- Author(s)
  林大輝、山本篤司、立松洋平、岡戸みな美、大倉一人
- Organizer
  第50回日本薬学会東海支部会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] ミトコンドリア酸素消費を指標とした薬剤放出のリアルタイム解析2013
- Author(s)
  山本篤司、立松洋平、林大輝、岡戸みな美、大倉一人
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] β溶血性Streptococcus anginosusが保有するストレプトリジンSホモログの特徴と細胞障害性への寄与2013
- Author(s)
  田端厚之、中野晃太、大倉一人、菊池賢、友安俊文、長宗秀明
- Organizer
  第22回Lancefieldレンサ球菌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] ミトコンドリア酸素消費を指標とした薬物放出リアルタイムモニタリングシステムの構築2013
- Author(s)
  立松洋平、山本篤司、林大輝、岡戸みな美、大倉一人
- Organizer
  第50回日本薬学会東海支部会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] コレステロール依存性細胞溶解毒素の受容体認識および作用特性における多様性2013
- Author(s)
  田端厚之、大倉一人、友安俊文、大國寿士、長宗秀明
- Organizer
  第60回毒素シンポジウム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] S.constellatus subsp. constellatus が保有するβ溶血因子の探索2013
- Author(s)
  Atsushi Tabata, Yuji Sato, Kota Nakano, Kazuto Ohkura, Ken Kikuchi, Tishifumi Tomoyasu, Hideaki Nagamune
- Organizer
  第８６回日本細菌学会
- Place of Presentation
  幕張メッセ国際会議場
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] 細菌由来細胞溶解毒素のヒト側受容体との相互作用2012
- Author(s)
  大倉一人、川口遊喜、田端厚之、篠原康雄、長宗秀明
- Organizer
  第１６回バイオ治療法研究会
- Place of Presentation
  東京理科大学森戸記念館
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] 非ステロイド性抗炎症薬のミトコンドリアに対する作用を指標とした副作用発現メカニズムの解析2012
- Author(s)
  山本篤司、立松洋平、林大輝、岡戸みな美、大倉一人
- Organizer
  第３１回日本社会薬学会
- Place of Presentation
  鈴鹿医療科学大学白子キャンパス
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] β溶血性Streptococcus anginosusが保有するペプチド性溶血因子の分子特性2012
- Author(s)
  田端厚之、中野晃太、大倉一人、友安俊文、菊池賢、長宗秀明
- Organizer
  第６回細菌学若手コロッセウム
- Place of Presentation
  八王子セミナーハウス
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] コレステロール依存性細胞溶解毒素の膜孔形成活性に対する糖の抑制効果 Investigation for the inhibitory effect of sugars on the pore-formation of cholesterol-dependent cytolysins
- Author(s)
  玉岡雅章、竹田望、田端厚之、大倉一人、友安俊文、大國寿士、長宗秀明
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] Streptolysin S homologues of peptide hemolysin: Novel beta-hemolytic factors distributed among beta-hemolytic anginosus group Streptococci
- Author(s)
  Atsushi Tabata, Kota Nakano, Yuji Sato, Kentaro Maya, Hiromi Ohtani, Yukimasa Ohkubo, Kazuto Ohkura, Ken Kikuchi, Robert Whiley, Toshifumi Tomoyasu, Hideaki Nagamune
- Organizer
  XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases
- Place of Presentation
  アルゼンチン
- Year and Date
  2014-11-09 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] β溶血性アンギノーサス群レンサ球菌が保有するストレプトリジンSホモログの多様性
- Author(s)
  田端厚之、眞屋健太郎、大谷浩美、佐藤裕士、中野晃太、大倉一人、菊池賢、友安俊文、長宗秀明
- Organizer
  第46回レンサ球菌研究会
- Place of Presentation
  東京
- Year and Date
  2014-06-27 – 2014-06-28
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] S. anginosus subsp. whileyiおよびS. constellatus subsp. viborgensisが保有するβ溶血因子の特性解析　Characterization of β-hemolytic factor of S. anginosus subsp. whileyi and S. constellatus subsp. viborgensis
- Author(s)
  眞屋健太朗、田端厚之、大倉一人、菊池賢、友安俊文、長宗秀明
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590221
[Presentation] 非ステロイド性抗炎症薬によるミトコンドリア膜障害を介した副作用発現機構解析
- Author(s)
  山本篤司、立松洋平、林大輝、藤田明日、田口諒、大倉一人
- Organizer
  第36回生体膜と薬物の総合作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24590221

1. NAGAMUNE Hideaki (40189163)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
2. HORI Hitoshi (90119008)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 田端厚之 (10432767)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
4. GOTO Satoru (50253232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUGE Hideaki (40299342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 牧野志雄 (80000842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 友安俊文 (20323404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

ohkura kazuto 大倉 一人

OHKURA Kazuto 大倉 一人

OHKURA kazuo 大倉 一人

大倉 一人 オオクラ カズト

Research Projects

Research Products

Co-Researchers

Molecular characteristics specific for streptolysin S produced by human opportunistic Anginosus group streptococci

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Structural and functional analysis of cytotoxic factors derived from pathogenic streptococci and their application to infection controlPrincipal Investigator

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Functional analysis of streptococcal toxinsPrincipal Investigator

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Functional analysis of streptolysin S involved factorsPrincipal Investigator

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Molecular analysis of streptococcus derived protein factors for application to drug discoveryPrincipal Investigator

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Dynamic structure of intermedilysin : Analysis of membrane binding regionPrincipal Investigator

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Analysis of Intermedilysin in Human Specific Cytolytic Mechanism : Design and Application for Cell Targeting Module.Principal Investigator

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Analysis of Structural Similarity of Molecular Dynamics Application for the Induction of Cell DifferentiationPrincipal Investigator

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大豆グリシニンのインスリン作用増強効果

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Research Institution

[Journal Article] Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors2023

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[Journal Article] Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S-producing streptococci.2023

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[Journal Article] Molecular Aspects of C-glycosides: Interactive Analysis of C-linked Compounds With the SGLT2 Molecular Model2023

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[Journal Article] Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.2022

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ohkura kazuto 大倉一人

OHKURA Kazuto 大倉一人

OHKURA kazuo 大倉一人

大倉一人オオクラカズト