YOSHIMASA Yasunao 吉政康直

… Alternative Names

吉政康直ヨシマサヤスナオ

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Researcher Number	00252437
Affiliation (based on the past Project Information) *help	2008: 国立循環器病センター, 部長 2005: 国立循環器病センター(研究所), (動脈硬化代謝内科), 部長 2003: National Cardiovascular Center, Division of Atherosclerosis, Metabolism and Clinical Nutrition, Director, 動脈硬化代謝部, 部長 2001 – 2002: Kyoto University Graduate School of Medicine Assistant Professor, 部長 2000 – 2001: 国立循環器病センター, 動脈硬化・代謝部, 部長 … More 2000: 京大, 医学(系)研究科, 講師 1999 – 2000: 京都大学, 大学院・医学研究科, 講師 1997 – 1998: 京都大学, 医学研究科, 講師 1997: 京都大学, 大学院・医学研究科, 講師 1996: 京都大学, 医学研究科, 助手 1996: 京都大学, 大学院・医学研究科, 助手 1995: 財団法人生産開発科学研究所, 主任研究員 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics Except Principal Investigator Metabolomics / 内分泌・代謝学 / Endocrinology / Endocrinology / Biological Sciences
Keywords	Principal Investigator MAPキナーゼ / MAPキナーゼ・キナーゼ / 3T3-L1脂肪細胞 / インスリン / 糖輸送担体 / PI3キナーゼ / シグナル伝達 / Adipocyte differentiation / Insulin resistance / Glucose transporter … More / MAP kinase kinase / MAP kinase / 3T3-L1 adipocyte / 脂肪細胞分化 / インスリン抵抗性 / MAPキナーゼ. キナーゼ / チアゾリジン誘導体 / GLUT4 / 糖輸送 / インスリン作用 / レプチン / ワルトマニン … More Except Principal Investigator 肥満 / 骨格筋 / notch / nestin / neurogenin3 / UCP / 脂肪細胞 / レプチン / pancreatic duct cells / regeneration / B cell / von Willebrand factor / 血管内皮細胞 / streptozotocin膵β細胞再生モデルラット / Notch / 内胚葉 / 膵臓 / 未分化 / 中枢神経系 / 膵管細胞 / 再生 / β細胞 / glycogen / glucose transport / signal transduction / muscle contraction / exercise / glucose metabolism / skeletal muscle / AMP kinase / グリコーゲン / 糖輸送 / シグナル伝達 / 筋収縮 / 運動 / 糖代謝 / AMPキナーゼ / energy consumption / energy metabolism / diabetes / obesity / 脱共役蛋白質3 / エネルギー消費 / エネルギー代謝 / 糖尿病 / Obesity / Skeletal Muscle / Adipocyte / Insulin Action / Thiazolidinedione / Leptin / 糖輸送担体 / TSH / GLUT4 / レプチン受容体 / イソプロテレノール / インスリン / インスリン作用 / チアゾリジン誘導体 / Toll-like receptor 4 / 多価不飽和脂肪酸 / 飽和脂肪酸 / メタボリックシンドローム / 炎症 / マクロファージ / 脂肪酸 / 情報量基準 / 予測式 / 統計モデル / SNP / ゲノム多型 / 代謝疾患 / トランスジェニックマウス / 肥満遺伝子 Less

Pro-inflammatory role of free fatty acids in the pathophysiology of the metabolic syndrome
- Principal Investigator
  
  SUGAMI Takayoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Endocrinology
- Research Institution
  Tokyo Medical and Dental University
疾患関連遺伝子SNP情報の組み合わせによる代謝疾患病態予測システムの構築
- Principal Investigator
  
  森崎隆幸
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
Molecular mechanisms controlling pancreatic β cell regeneration and pathophysiological significance of pancreatic nestin-expressing cells
- Principal Investigator
  
  HOSODA Kiminori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  KYOTO UNIVERSITY
ELUCIDATION OF SIGNIFICANCE OF UCP3 IN DIABETES AND OBESITY USING TRANSGENIC MICE
- Principal Investigator
  
  HOSODA Kiminori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Effects of Exercise-Induced Activation of 5'AMP-Activated Protein Kinase (AMPK) on Glucose Metabolism in Skeletal Muscle
- Principal Investigator
  
  HAYASHI Tatsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
肥満関連遺伝子のインスリン作用機構への組織特異的影響に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  吉政康直
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
A role of MAP kinase in the pathogenesis of insulin resistancePrincipal Investigator
- Principal Investigator
  
  YOSHIMASA Yasunao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
脂肪細胞における肥満遺伝子とインスリン作用関連遺伝子の制御機構の研究
- Principal Investigator
  
  NISHIMURA Haruo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
インスリンによる糖輸送に関与するインスリンシグナル伝達経路に関する研究Principal Investigator
- Principal Investigator
  
  吉政康直
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
肥満遺伝子過剰発現トランスジェニックマウスの開発-肥満遺伝子の臨床的意義の解明-
- Principal Investigator
  
  細田公則
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
インスリン非依存性糖尿病におけるMAPキナーゼ経路の意義に関する研究Principal Investigator
- Principal Investigator
  
  吉政康直
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Research Institute for Production Development

All 2008 2007 2006

All Journal Article Presentation

[Journal Article] Effect of peroxisome proliferator-activated receptor a ligands in the interaction between adipocytes and macrophages in obese adipose tissue2008
- Author(s)
  T. Toyoda, Y. Kamei, H. Kato, S. Sugita, M. Takeya, T. Suganami, Y. Ogawa
- Journal Title
  
  Obesity 16
  
  Pages: 1199-1207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Regulation of SREBP1c gene expression in skeletal muscle: role of RXR/LXR and FOX012008
- Author(s)
  Y. Kamei, S. Miura, T Suganami, F. Akaike, S. Kanai, S. Sugita, A. Katsumata, H. Aburatani, TG. Unterman, O. Ezaki, Y. Ogawa
- Journal Title
  
  Endocrinology 149
  
  Pages: 293-2305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue2008
- Author(s)
  A. Ito, T. Suganami, A. Yamauchi, M. Degawa-Yamauchi, M. Tanaka, R. Kouyama, Y. Kobayashi, N. Nitta, K. Yasuda, Y. Hirata, WA. Kuziel, M. Takeya, S. Kanegasaki, Y. Kamei, Y. Ogawa
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 35715-35723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid2008
- Author(s)
  H. Yamada, M. Yoshida, Y. Nakano, T. Suganami, N. Satoh, T Mita, K. Azuma, M. Itoh, Y. Yamamoto, Y. Kamei, M. Horie, H. Watada, Y. Ogawa
- Journal Title
  
  Arterioscler. Thromb. Vase. Biol. 28
  
  Pages: 2173-2179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and CRP in metabolic syndrome2007
- Author(s)
  N. Satoh, A. Shimatsu, K. Kotani, N. Sakane, K. Yamada, T. Suganami, H. Kuzuya, Y. Ogawa
- Journal Title
  
  Diabetes Care 30
  
  Pages: 144-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy2007
- Author(s)
  A. Ito, T. Suganami, Y. Miyamoto, Y. Yoshimasa, M. Takeya, Y. Kamei, Y. Ogawa
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 15445-25452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Macrophage-colony stimulating factor in obese adipose tissue: studies with heterozygous op/+ mice2007
- Author(s)
  S. Sugita, Y. Kamei, J. Oka, T. Suganami, Y. Ogawa
- Journal Title
  
  Obesity 15
  
  Pages: 1988-1995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Pegl/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner2007
- Author(s)
  Y. Kamei, T. Suganami, T. Kohda, F. Ishino, K. Yasuda, S. Miura, O. Ezaki, Y. Ogawa
- Journal Title
  
  FEBS Letters 581
  
  Pages: 91-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects2007
- Author(s)
  M. Itoh, T. Suganami (co-corresponding author), N. Satoh, K. Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano, S. Aoe, M. Takeya, A. Shimatsu, H. Kuzuya, Y. Kamei, Y. Ogawa
- Journal Title
  
  Arterioscler. Thromb. Vase. Biol. 27
  
  Pages: 1918-1925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development2007
- Author(s)
  R. Hachiya, Y. Ohashi, Y. Kamei, T. Suganami, H. Mochizuki, N. Mitsui, M. Saitoh, M. Sakuragi, G. Nishimura, H. Ohashi, T. Hasegawa, Y. Ogawa
- Journal Title
  
  J. Clin. Endocrinol. Metab. 92
  
  Pages: 4009-4014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-Iike receptor 4mutation2007
- Author(s)
  T. Suganami, T. Mieda, M. Itoh, Y. Shimoda, Y. Kamei, Y. Ogawa
- Journal Title
  
  Biochem. Biophys. Res. Commun. 354
  
  Pages: 45-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Role of the Toll-like receptor 4/NF-κB pathway in saturated fatty acid-induced inflammatory change in the interaction between adipocytes and macrophages2007
- Author(s)
  T. Suganami, K. Tammoto-Koyama, J. Nishida, M. Itoh, X. Yuan, S. Mizuarai, H. Kotani, S. Yamaoka, K. Miyake, S. Aoe, Y. Kamei, Y. Ogawa
- Journal Title
  
  Arterioscler. Thromb. Vase. Biol. 27
  
  Pages: 84-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals2006
- Author(s)
  J. Park, SS. Choe, AH. Choi, KH. Kim, MJ. Yoon, T. Suganami, Y. Ogawa, JB. Klm
- Journal Title
  
  Diabetes 55
  
  Pages: 2939-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Journal Article] An α-glucosidase inhibitor voglibose reduces oxidative stress markers and soluble intercellular adhesion molecule-1 in obese type 2 diabetes2006
- Author(s)
  N. Satoh, A. Shimatsu, K. Yamada, M. Aizawa-Abe, T. Suganami, H. Kuzuya, Y. Ogawa
- Journal Title
  
  Metabolism 55
  
  Pages: 786-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689022
[Presentation] Role of the Toll-like Receptor 4/NF-kB Pathway in Saturated Fatty Acid-induced Inflammatory Changes in the Interaction between Adipocytes and Macrophages2007
- Author(s)
  T. Suganami, Y. Ogawa
- Organizer
  Keystone Symposia
- Place of Presentation
  Steamboat Springs, USA
- Data Source
  KAKENHI-PROJECT-18689022
[Presentation] Aparacrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor-α2006
- Author(s)
  T. Suganami, Y. Kamei, Y. Ogawa
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-18689022

1. HOSODA Kiminori (40271598)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. INOUE Gen (20260606)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HAYASHI Tatsuya (00314211)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. ITOH Hiroshi (40252457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NISHIMURA Haruo (40281729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 西重生 (80218099)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUGAMI Takayoshi (50343752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
8. YOSHIDA Masayuki (80282771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SATO Noriko (80373512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 森崎隆幸 (30174410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森崎裕子 (40311451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 宮本恵宏 (10312224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小川佳宏 (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIMASA Yasunao 吉政 康直

吉政 康直 ヨシマサ ヤスナオ

Research Projects

Research Products

Co-Researchers

Pro-inflammatory role of free fatty acids in the pathophysiology of the metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

疾患関連遺伝子SNP情報の組み合わせによる代謝疾患病態予測システムの構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms controlling pancreatic β cell regeneration and pathophysiological significance of pancreatic nestin-expressing cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ELUCIDATION OF SIGNIFICANCE OF UCP3 IN DIABETES AND OBESITY USING TRANSGENIC MICE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of Exercise-Induced Activation of 5'AMP-Activated Protein Kinase (AMPK) on Glucose Metabolism in Skeletal Muscle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肥満関連遺伝子のインスリン作用機構への組織特異的影響に関する分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of MAP kinase in the pathogenesis of insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪細胞における肥満遺伝子とインスリン作用関連遺伝子の制御機構の研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インスリンによる糖輸送に関与するインスリンシグナル伝達経路に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肥満遺伝子過剰発現トランスジェニックマウスの開発-肥満遺伝子の臨床的意義の解明-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インスリン非依存性糖尿病におけるMAPキナーゼ経路の意義に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of peroxisome proliferator-activated receptor a ligands in the interaction between adipocytes and macrophages in obese adipose tissue2008

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of SREBP1c gene expression in skeletal muscle: role of RXR/LXR and FOX012008

Author(s)

Journal Title

Data Source

[Journal Article] Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue2008

YOSHIMASA Yasunao 吉政康直

吉政康直ヨシマサヤスナオ