HOSHINO Tomoaki 星野友昭

Researcher Number	00261066
Other IDs
Affiliation (Current)	2020: 久留米大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2019: 久留米大学, 医学部, 教授 2014: 久留米大学, 内科学講座呼吸器・神経・膠原病内科部門, 主任教授 2011: 久留米大学, 医学部, 教授 2010: 久留米大学, 医学部, 准教授 2009: Kurume University, 医学部, 講師 … More
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Biological Sciences / Respiratory organ internal medicine / 内科学一般 / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / Pathological medical chemistry / Experimental pathology / Digestive surgery / Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator サイトカイン / マウスモデル / IL-18 / 間質性肺炎 / NK細胞 / ケモカイン / 特発性間質性肺炎 / レドックス蛋白 / thioredoxin / 肺リモデリング … More Except Principal Investigator 癌 / サイトカイン / BALF / 遺伝子改変マウス / 接着分子 / 早期診断 / 遺伝子同定 / 癌退縮抗原 / TGFβ / バイオマーカー / 特発性肺線維症 / ペリオスチン / サルコイドーシス / CD3 / CD28 / CD80 / CD86 / T細胞 / cytokine / Th1 / Th2 / 免疫学 / COPD / 癌拒絶抗原遺伝子 / キラーT細胞(CTL) / 癌特異免疫療法 / ペプチド分子 / 上皮性癌 / 癌ペプチドワクチン / HLA-A24 / HLA-A2 / 遺伝子クローニング / 扁平上皮癌 / HLA-A2601拘束性 / キラーT細胞 / 抗原ペプチド / SART-1遺伝子 / 癌免疫 / 腫瘍 / 卵巣癌 / HLA拘束性 / Mast cell / Myofibroblast / VEGF / mast cell / myofibroblast / fibroblast / smooth muscle actin / TGF / fibrosis / soluble factor / ぺリオスチン / 間質性肺炎 / 特発性間質性肺炎 / 血清バイオマーカー / LFA-1様抗原 / 悪性腫瘍 / 外分泌腺 / LFA-1-like molecule / LFA-1 / CD11a / Adhesion molecule / Exocrine glands / Malignant tumors / adenocarcinoma / CD4^+T細胞 / 副シグナル / CD4^+ T細胞 / 抗原提示細胞 / 眼房水 / 抗原刺激 / 結節成形 / sarcoidosis / CD4^+ T cell / Second signal / 肺サルコイドーシス症 / 抗原 / T細胞レセプター / サルコイドーシス症 / TCR Vα / TCR Vβ / non-restpiction / HLA Class II / HLA Class I / Pulmonary sarcoidosis / Antigen / T lymphocytes / T cell receptor / IL-18 / IL-18受容体 / IgE / Cytokines / Transgenic mouse / Allergy / 動脈硬化 / 炎症 / Th1反応 / インターロイキン-4(IL-4) / 培養細胞 / Thl反応 / atherosclerosis / inflammation / Th1 response / interleukin-4 (IL-4) / mouse / cell culture / Cancer / Immunology / 酸化還元 / Cytokine / Oxidant stress / コンパニオン診断薬 / 関節炎 / CD163陽性マクロファージ / ケモカイン / 炎症性サイトカイン / M2マクロファージ / マウス関節炎モデル / LPS / マクロファージ / M1　M2　バランス / 骨破壊 / 炎症細胞浸潤 / 内科 / HMC-1 / 線維芽細胞 / Type　I　collgen / マスト細胞 / シェーグレン症候群 Less

Regulation of IL-18, IL-38 and complements for the treatment of inflammatory pulmonary diseasesPrincipal InvestigatorOngoing
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kurume University
マスト細胞を介したシェーグレン症候群唾液腺炎メカニズム解析と治療への応用Ongoing
- Principal Investigator
  
  海江田信二郎
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kurume University
The study of periositin, a new biomarker of idiopathic pulmonary fibrosis
- Principal Investigator
  
  Masaki Okamoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Regulation of IL-18 and IL-38 for the treatment of inflammatory pulmonary diseasesPrincipal Investigator
- Principal Investigator
  
  Hoshino Tomoaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
The involvement of M2 CD163 positive macrophages in the development of arthritis
- Principal Investigator
  
  kaieda Shinjiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kurume University
The involvement of mast cells in the development of lung fibrosis
- Principal Investigator
  
  Kaieda Shinjiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Roles of new cytokine IL-38 in inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  Hoshino Tomoaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Development of new biomarker of interstitial pneumonia and drug-induced lung disease
- Principal Investigator
  
  MASAKI Okamoto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Study for roles of inflammatory cells and cytokines in asthma death, COPD and mouse pulmonary disease modelsPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tomoaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
抗癌剤による肺障害の分子機構解析と新規治療薬開発Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Study for therapy in COPD patients by regulating proinflammatory cytokine and oxidant stress
- Principal Investigator
  
  AIZAWA Hisamichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Study for roles of proinflammatory cytokine IL-18 and redox signals in the pathogenesis of interstitial lung diseasesPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tomoaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Study on anti-tumor effects of IL-18-analysis of IL-18 transgenic mouse with CD11b promoter gene
- Principal Investigator
  
  SEKI Naoko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kurume University
間質性肺炎の原因遺伝子解明と新規治療薬開発Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
抗癌剤による急性肺障害の分子機構の解析と予防治療法の開発Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Development of therapeutics using interleukin-4 (IL-4) mutein in atherosclerotic mouse model showing Th1-dominant immune response
- Principal Investigator
  
  KATO Seiya
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of the Ryukyus
  Kurume University
間質性肺炎の原因遺伝子解明と新規治療薬開発Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
Study for roles of IL-18 in interstitial lung diseases and lung remodelingPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
新規マウスモデルを用いた間質性肺炎(肺線維症)原因遺伝子解明と治療薬開発Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
IL-18で誘導される間質性肺炎の遺伝子解析と臨床応用への基盤的研究Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
Basic Research for Prevention of Interstitial Lung Diseases Induced by IL-18Principal Investigator
- Principal Investigator
  
  HOSHINO Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KURUME UNIVERSITY
IL-18で誘導される間質性肺炎マウスモデルの遺伝子解析と臨床応用への基盤的研究Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
Molecular immunological analysis for IgE production and a unique NK cell population producing type 2 cytokine, IL-13Principal Investigator
- Principal Investigator
  
  HOSHINO Tomoaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  KURUME UNIVERSITY
Analysis of IL-18 for anti-tumor effect in patients with lung cancer : Cloning a new IL-18 receptor.
- Principal Investigator
  
  OIZUMI Kotaro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KURUME UNIVERSITY
HLA−A3302拘束性肺腺癌特異的癌退縮抗原遺伝子の同定Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
ヒト自家癌腫瘍に対するCLT株作製に基づく腫瘍特異免疫療法
- Principal Investigator
  
  伊東恭悟
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
HLA-A2拘束性卵巣癌特異的癌退縮抗原遺伝子のクローニング
- Principal Investigator
  
  山田亮
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
HLA-A33 拘束性肺腺癌特異的癌退縮抗原遺伝子の同定Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
Identification of pulmonary sarcoidosis related antigen.
- Principal Investigator
  
  OIZUMI Kotaro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University School of Medicine
サルコイドーシス症病変部T細胞の分子免疫学的解析Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
接着分子を用いた癌の早期診断:癌患者外分泌腺上LFA-1(様)抗原の遺伝子同定
- Principal Investigator
  
  YAMADA Akira
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
成人Still病患者におけるTCRγδ型T細胞抗原レセプター遺伝子の解析Principal Investigator
- Principal Investigator
  
  星野友昭
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Kurume University
Molecular Characterizaiton of LFA-1-like Molecule on Exocrine Glands in Patients with Malignant Tumor.
- Principal Investigator
  
  YAMADA Akira
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kurume University School of Medicine
Molecular immunoanalysis of pulmonary sarcoidosis
- Principal Investigator
  
  OIZUMI Kotaro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University

[Book] 遺伝子操作動物モデルの作製法。呼吸器疾患研究の展望基礎から臨床まで (相沢久道, 一ノ瀬正和編)2006
- Author(s)
  星野友昭, 相澤久道
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-18390244
[Book] 遺伝子操作動物モデルの作製法。呼吸器疾患研究の展望基礎から臨床まで(相沢久道、一ノ瀬正和編)2006
- Author(s)
  星野友昭, 相澤久道
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-18659244
[Book] 遺伝子操作動物モデルの作製法。呼吸器疾患研究の展望基礎から臨床まで(相沢久道, 一之瀬正和編)2006
- Author(s)
  星野友昭, 相澤久道
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17390244
[Book] 遺伝子操作動物モデルの作製法。呼吸器疾患研究の展望基礎から臨床まで(相沢久道、一ノ瀬正和編)2006
- Author(s)
  星野友昭, 相澤久道
- Publisher
  医学書院
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Book] IL-18 サイトカイン・増殖因子用語ライブラリー(菅村和夫、宮園貢、平浩平、宮澤恵二、田中伸幸編)2005
- Author(s)
  星野友昭
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] A Retrospective Study of the Tolerability of Nintedanib for Severe Idiopathic Pulmonary Fibrosis in the Real World2019
- Author(s)
  Nakamura M, Okamoto M, Fujimoto K, Ebata T, Tominaga M, Nouno T, Zaizen Y, Kaieda S, Tsuda T, Kawayama T, Hoshino T
- Journal Title
  
  Annals of Translational Medicine
  
  Volume: 7 Pages: 262-270
- DOI
  10.21037/atm.2019.05.33
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08898
[Journal Article] Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor.2019
- Author(s)
  Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
- Journal Title
  
  Int J Cancer.
  
  Volume: 144 Issue: 5 Pages: 1170-1179
- DOI
  10.1002/ijc.31923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19490, KAKENHI-PROJECT-17H04278, KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-16K09596, KAKENHI-PROJECT-16H06277
[Journal Article] Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients.2019
- Author(s)
  Nouno T, Okamoto M, Ohnishi K, Kaieda S, Tominaga M, Zaizen Y, Ichiki M, Momosaki S, Nakamura M, Fujimoto K, Fukuoka J, Shimizu S, Komohara Y, Hoshino T.
- Journal Title
  
  J Thorac Dis
  
  Volume: 11 Pages: 4004-4017
- DOI
  10.21037/jtd.2019.09.03
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08898, KAKENHI-PROJECT-17H04060
[Journal Article] Clinical Characteristics of Relapsing Polychondritis: A Report of 8 Cases in Japan2019
- Author(s)
  Tajiri M, Tominaga M, Kinoshita T, Nakamura M, Kaieda S, Okamoto M, Ida H, Kawayama T, Hoshino T
- Journal Title
  
  Kurume Med. J.
  
  Volume: in press Issue: 2 Pages: 47-53
- DOI
  10.2739/kurumemedj.ms652006
  10.2739/kurumemedj.MS652006
- NAID
  130007650020
- ISSN
  0023-5679, 1881-2090
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09912
[Journal Article] Ability of Periostin as a New Biomarker of Idiopathic Pulmonary Fibrosis.2019
- Author(s)
  Okamoto M, Izuhara K, Ohta S, Ono J, Hoshino T.
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1132 Pages: 79-87
- DOI
  10.1007/978-981-13-6657-4_9
- Data Source
  KAKENHI-PROJECT-16K09567
[Journal Article] Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model2019
- Author(s)
  MATSUOKA MASANOBU、KAWAYAMA TOMOTAKA、TOMINAGA MASAKI、KAIEDA SHINJIRO、TOKUNAGA YOSHIHISA、KAKU YOICHIRO、IMAOKA HARUKI、KINOSHITA TAKASHI、OKAMOTO MASAKI、AKIBA JUN、HOSHINO TOMOAKI
- Journal Title
  
  Kurume Med. J.
  
  Volume: 65 Issue: 2 Pages: 37-46
- DOI
  10.2739/kurumemedj.ms652009
  10.2739/kurumemedj.MS652009
- NAID
  130007650022
- ISSN
  0023-5679, 1881-2090
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-16K09912
[Journal Article] Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome2018
- Author(s)
  Weiss Eric S.、Girard-Guyonvarc’h Charlotte、Holzinger Dirk、de Jesus Adriana A.、Tariq Zeshan、Picarsic Jennifer、Schiffrin Eduardo J.、Foell Dirk、Grom Alexei A.、Ammann Sandra、Ehl Stephan、Hoshino Tomoaki、Goldbach-Mansky Raphaela、Gabay Cem、Canna Scott W.
- Journal Title
  
  Blood
  
  Volume: 131 Pages: 1442-1455
- DOI
  10.1182/blood-2017-12-820852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595
[Journal Article] Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy2018
- Author(s)
  Koga T, Kaieda S, Okamoto M, Masuda K, Fujimoto K, Sakamoto S, Nakamura M, Tominaga M, Kawayama T, Fujimoto K, Hoshino T, Ida H.
- Journal Title
  
  Internal Medicine
  
  Volume: 57 Pages: 1039-1043
- NAID
  130006602620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09912
[Journal Article] Low positive titer of anti-melanoma differentiation-associated gene 5 antibody is not associated with a poor long-term outcome of interstitial lung disease in patients with dermatomyositis.2018
- Author(s)
  Sakamoto S, Okamoto M, Kaieda S, Fujimoto K, Nagata S, Tominaga M, Nakamura M, Zaizen Y, Nouno T, Koga T, Kawayama T, Kuwana M, Ida H, Hoshino T.
- Journal Title
  
  Respir Investig
  
  Volume: 56 Pages: 464-472
- DOI
  10.1016/j.resinv.2018.07.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09567, KAKENHI-PROJECT-16K09912
[Journal Article] Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy2018
- Author(s)
  Koga T, Kaieda S, Okamoto M, Masuda K, Fujimoto K, Sakamoto S, Nakamura M, Tominaga M, Kawayama T, Fujimoto K, Hoshino T, Ida H.
- Journal Title
  
  Internal Medicine
  
  Volume: 57 Issue: 7 Pages: 1039-1043
- DOI
  10.2169/internalmedicine.9553-17
- NAID
  130006602620
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09559, KAKENHI-PROJECT-16K09912, KAKENHI-PROJECT-16K09913
[Journal Article] IL-33/ST2 contributes to severe symptoms in Plasmodium chabaudi -infected BALB/c mice2018
- Author(s)
  Seki T, Obata-Ninomiya K, Shimogawara-Furushima R, Arai T, Akao N, Hoshino T, Ohta N.
- Journal Title
  
  Parasitology International
  
  Volume: 印刷中 Pages: 64-69
- DOI
  10.1016/j.parint.2017.03.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-17K15675
[Journal Article] Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression2017
- Author(s)
  Takada Kazuki、Okamoto Tatsuro、Tominaga Masaki、Teraishi Koji、Akamine Takaki、Takamori Shinkichi、Katsura Masakazu、Toyokawa Gouji、Shoji Fumihiro、Okamoto Masaki、Oda Yoshinao、Hoshino Tomoaki、Maehara Yoshihiko
- Journal Title
  
  PLOS ONE
  
  Volume: 12
- DOI
  10.1371/journal.pone.0181598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595
[Journal Article] Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis.2017
- Author(s)
  Tominaga Masaki、Okamoto Masaki、Kawayama Tomotaka、Matsuoka Masanobu、Kaieda Shinjiro、Sakazaki Yuki、Kinoshita Takashi、Mori Daisuke、Inoue Akira、Hoshino Tomoaki
- Journal Title
  
  Respir Investig
  
  Volume: 55 Pages: 293-299
- DOI
  10.1016/j.resinv.2017.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-15K09559
[Journal Article] Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease.2017
- Author(s)
  Yoshida N, Okamoto M, Kaieda S, Fujimoto K, Ebata T, Tajiri M, Nakamura M, Tominaga M, Wakasugi D, Kawayama T, Kuwana M, Mimori T, Ida H, Hoshino T
- Journal Title
  
  Respiratory investigation
  
  Volume: 55(1) Pages: 24-32
- DOI
  10.1016/j.resinv.2016.08.007
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05341, KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-16K09913
[Journal Article] The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis.2017
- Author(s)
  Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, Kushima H, Ishii H, Akasaka K, Ono J, Kamei A, Azuma Y, Matsumoto H, Yamaguchi Y, Aihara M, Johkoh T, Kawaguchi A, Ichiki M, Sagara H, Kadota JI, Hanaoka M, Hayashi SI, Kohno S, Hoshino T, Izuhara K
- Journal Title
  
  PLOS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0174547
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09595, KAKENHI-PROJECT-16K10168, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-16K09535, KAKENHI-PROJECT-16K09567, KAKENHI-PROJECT-17K09618
[Journal Article] Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis.2017
- Author(s)
  Tominaga M, Okamoto M, Kawayama T, Matsuoka M, Kaieda S, Sakazaki Y, Kinoshita T, Mori D, Inoue A, Hoshino T.
- Journal Title
  
  Respiratory Investigation
  
  Volume: 55 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09912
[Journal Article] IL-38: A new factor in rheumatoid arthritis2015
- Author(s)
  S-i Takenaka, S Kaieda, T Kawayama, M Matsuoka, Y Kaku, T Kinoshita, Y Sakazaki, M Okamoto, T Hoshino
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 4 Pages: 386-391
- DOI
  10.1016/j.bbrep.2015.10.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461202
[Journal Article] Interleukin-18 expression, CD8+ T cells, and eosinophils in lungs of nonsmokers with fatal asthma.2014
- Author(s)
  Oda H, Kawayama T, Imaoka H, Sakazaki Y, Kaku Y, Okamoto M, Kitasato Y, Edakuni N, Takenaka S, Yoshida M, Iwanaga T, Kato S, O'Byrne PM, Hoshino T.
- Journal Title
  
  Asthma Immunol
  
  Volume: 112 Pages: 23-28
- Data Source
  KAKENHI-PROJECT-25860663
[Journal Article] The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model.2014
- Author(s)
  Takenaka S, Kawayama T, Imaoka H, Sakazakia Y, Oda H, Kaku Y, MatsuokaM, Okamoto M, Kato S, Yamada K, Hoshino T.
- Journal Title
  
  BBRC
  
  Volume: 445 Pages: 597-601
- Data Source
  KAKENHI-PROJECT-25860663
[Journal Article] 特集「間質性肺炎とアレルギー」　各論　特発性間質性肺炎とサイトカイン2014
- Author(s)
  岡元　昌樹、星野　友昭
- Journal Title
  
  アレルギーの臨床
  
  Volume: 33 Pages: 17-22
- Data Source
  KAKENHI-PROJECT-25860663
[Journal Article] IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13.2013
- Author(s)
  Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, Kaku Y, Azuma K, Tajiri, M, Edakuni N, Okamoto M, Kato S, Hoshino T.
- Journal Title
  
  PLos One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-25860663
[Journal Article] Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis2011
- Author(s)
  Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka SI, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H
- Journal Title
  
  Arthritis research & therapy
  
  Volume: 13
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD2011
- Author(s)
  Sakazaki, Y., Hoshino, T., 他
- Journal Title
  
  PLoS One
  
  Volume: 6
- DOI
  10.1371/journal.pone.0024177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Interleukin-18 and interleukin-18 receptor-alpha expression in allergic asthma2011
- Author(s)
  Imaoka, H., Hoshino, T., 他
- Journal Title
  
  Eur Respir J
  
  Volume: 38 Pages: 981-3
- DOI
  10.1183/09031936.00033811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Overexpression of chitinase 3-like 1/ykl-40 in lung-specific il-18-transgenic mice, smokers and copd2011
- Author(s)
  Sakazaki Y, Hoshino T, Takei S, Sawada M, Oda H, Takenaka S, Imaoka H, Matsunaga K, Ota T, Abe Y, Miki I, Fujimoto K, Kawayama T, Kato S, Aizawa H
- Journal Title
  
  PloS one
  
  Volume: 6 Pages: 24177-24177
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias2011
- Author(s)
  Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H
- Journal Title
  
  Eur Respir J
  
  Volume: 37 Pages: 1119-1127
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Interleukin-18 and interleukin-18 receptor-alpha expression in allergic asthma2011
- Author(s)
  Imaoka H, Gauvreau GM, Watson RM, Smith SG, Dua B, Baatjes AJ, Howie K, Hoshino T, Killian KJ, Aizawa H, O' Byrne PM
- Journal Title
  
  Eur Respir J
  
  Volume: 38 Pages: 981-983
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias2011
- Author(s)
  Okamoto, M., Hoshino, T., 他
- Journal Title
  
  European Respiratory Journal
  
  Volume: 37 Pages: 1119-1127
- DOI
  10.1183/09031936.00059810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590977, KAKENHI-PROJECT-21591283, KAKENHI-PROJECT-22790934, KAKENHI-PROJECT-23591465
[Journal Article] Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia2010
- Author(s)
  Iwata Y, Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Tajiri M, Matsunaga K, Azuma K, Kawayama T, Kinoshita T, Imaoka H, Fujimoto K, Kato S, Yano H, Aizawa H
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 2393-2400
- NAID
  130000413366
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Exosome secretion of dendritic cells is regulated by hrs, an escrt-0 protein2010
- Author(s)
  Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 399 Pages: 384-390
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Role of Proinflammatory Cytokine IL-18 and IL-1beta in Bleomycin-induced Lung Injury in Humans and Mice2009
- Author(s)
  Hoshino T, 他
- Journal Title
  
  Am J Respir Cell Mol Biol 41
  
  Pages: 661-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590977
[Journal Article] Interleukin-18 production and pulmonary function in COPD.2008
- Author(s)
  Imaoka H, Hoshino T, Takei S, Kinoshita T, Okamoto M, Kawayama T, Kato S, Iwasaki H, Watanabe K, Aizawa H.
- Journal Title
  
  Eur Respir J. 31
  
  Pages: 287-297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Cytokines in Pulmonary Emphysema:Can Results in Mice Be Translated to Humans2008
- Author(s)
  Hoshino T, Aizawa H, 他
- Journal Title
  
  Am J Respir Crit Care Med. 177
  
  Pages: 238-239
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Redox-Regulated Mechanisms in Asthma.2008
- Author(s)
  Hoshino T, Okamoto M, Takei S, Sakazaki Y, Iwanaga T, Aizawa H.
- Journal Title
  
  Antioxid Redox Signal.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Cytokines in Pulmonary Emphysema : Can Results in Mice Be Translated to Humans?2008
- Author(s)
  Hoshino T, Young HA, Aizawa H.
- Journal Title
  
  Am J Respir Crit Care Med. 177
  
  Pages: 238-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] High levels of serum IL-18 promote cartilage loss through suppression of aggrecan synthesis.2008
- Author(s)
  Inoue H, Hiraoka K, Hoshino T, Okamoto M, Iwanaga T, Zenmyo M, Shoda T, Aizawa H, Nagata K.
- Journal Title
  
  Bone.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] IL-18 production and pulmonary function in chronic obstructive pulmonary disease.2008
- Author(s)
  Imaoka H, Hoshino T, Takei S, Kinoshita T, Okamoto M, Kawayama T, Kato S, Iwasaki H, Watanabe K, Aizawa H.
- Journal Title
  
  Eur Respir J 31
  
  Pages: 287-297
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Interleukin-18 production and pulmonary function in COPD2008
- Author(s)
  Imaoka H, Hoshino T, 他
- Journal Title
  
  Eur Respir J 31
  
  Pages: 287-297
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Cytokines in Pulmonary Emphysema: Can Results in Mice Be Translated to Humans2008
- Author(s)
  Hoshino T, Aizawa H, 他
- Journal Title
  
  Am J Respir Crit Care Med 177
  
  Pages: 238-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Interleukin-18 production and pulmonary function in COPD2008
- Author(s)
  Imaoka H, Hoshino T, 他
- Journal Title
  
  Eur Respir J 31
  
  Pages: 287-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659244
[Journal Article] Interleukin-18 production and puimonary function in COPD2008
- Author(s)
  Imaoka H, Hoshino T, 他
- Journal Title
  
  Eur Respir J 31
  
  Pages: 287-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary inflammation and emphysema: role of the cytokines IL-18and IL-13.2007
- Author(s)
  Hoshino T
- Journal Title
  
  Am J Respir Crit Care Med 176
  
  Pages: 49-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Pulmonary Inflammation and Emphysema : Role of the Cytokines IL-18 and IL-13.2007
- Author(s)
  Hoshino, T., S.Kato, N.Oka, H.Imaoka, T.Kinoshita, S.Takei, Y.Kitasato, T.Kawayama, T.Imaizumi, K.Yamada, H.A.Young, H.Aizawa.
- Journal Title
  
  Am J Respir Grit Care Med.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Thioredoxin prevents the development and progression of elastage-induced emphysema2007
- Author(s)
  Kinoshita T, Hoshino T, et al.
- Journal Title
  
  Biochemical and biophysical research communications 354
  
  Pages: 712-719
- Data Source
  KAKENHI-PROJECT-18659244
[Journal Article] Pulmonary Inflammation and Emphysema: Role of the Cytokines IL-18 and IL-132007
- Author(s)
  Hoshino T, 他
- Journal Title
  
  Am J Respir Crit Care Med 176
  
  Pages: 49-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary Inflammation and Emphysema : Role of the Cytokines IL-18 and IL-132007
- Author(s)
  Hoshino T, et al.
- Journal Title
  
  Am J Respir Crit Care Med. (In press)
- Data Source
  KAKENHI-PROJECT-18659244
[Journal Article] Pulmonary Inflammation and Emphysema:Role of the Cytokines IL-18 and IL-132007
- Author(s)
  Hoshino T, 他
- Journal Title
  
  Am J Respir Crit Care Med. 176
  
  Pages: 49-62
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13.2007
- Author(s)
  Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
- Journal Title
  
  Am J Respir Crit Care Med 176
  
  Pages: 49-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Pulmonary inflammation and emphysema : role of the cytokines IL-18and IL-13.2007
- Author(s)
  Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
- Journal Title
  
  Am J Respir Crit Care Med 176
  
  Pages: 49-62
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema2007
- Author(s)
  Kinoshita T, Hoshino T, et al.
- Journal Title
  
  Biochemical and biophysical research communications 354
  
  Pages: 712-719
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Effects of thioredoxin on established airway remodeling in a chronicantigen exposure asthma model.2007
- Author(s)
  Imaoka H, Hoshino T, Takei S, Sakazaki Y, Kinoshita T, Okamoto M, Kawayama T, Yodoi J, Kato S, Iwanaga T, Aizawa H.
- Journal Title
  
  Biochem Biophys Res Commun 360
  
  Pages: 525-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model.2007
- Author(s)
  Imaoka H, Hoshino T, Takei S, Sakazaki Y, Kinoshita T, Okamoto M, Kawayama T, Yodoi J, Kato S, Iwanaga T, Aizawa H.
- Journal Title
  
  Biochem Biophys Res Commun 360
  
  Pages: 525-530
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema2007
- Author(s)
  Kinoshita T, Hoshino T, et al.
- Journal Title
  
  Biochemical and biophysical research communications 354
  
  Pages: 712-719
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema.2007
- Author(s)
  Kinoshita T, Hoshino T, Imaoka H, Ichiki H, Okamoto M, Kawayama T, Yodoi J, Kato S, Aizawa H.
- Journal Title
  
  Biochemical and biophysical research communications. 354
  
  Pages: 712-719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema.2007
- Author(s)
  Kinoshita, T., T.Hoshino, H.Imaoka, H.Ichiki, M.Okamoto, T.Kawayama, J.Yodoi, S.Kato, H.Aizawa.
- Journal Title
  
  Biochem Biophys Res Commun 354
  
  Pages: 712-719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model.2007
- Author(s)
  Imaoka H, Hoshino T, Takei S, Sakazaki Y, Kinoshita T, Okamoto M, Kawayama T, Yodoi J, Kato S, Iwanaga T, Aizawa H.
- Journal Title
  
  Biochemical and biophysical research communications. 360
  
  Pages: 525-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary Inflammation and Emphysema : Role of the Cytokines IL-18 and IL-132007
- Author(s)
  Hoshino T, et al.
- Journal Title
  
  Am J Respir Crit Care Med. (In press)
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary Inflammation and Emphysema : Role of the Cytokines IL-18 and IL-13.2007
- Author(s)
  Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
- Journal Title
  
  Am J Respir Crit Care Med. 176
  
  Pages: 49-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Cloning and characterization of an isoform of interleukin-21.2007
- Author(s)
  Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino T, Asao H.
- Journal Title
  
  FEBS letters. 581
  
  Pages: 4001-4009
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Pulmonary Inflammation and Emphysema : Role of the Cytokines IL-18 and IL-132007
- Author(s)
  Hoshino T, et al.
- Journal Title
  
  Am J Respir Crit Care Med. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema.2007
- Author(s)
  Kinoshita T, Hoshino T, Imaoka H, Ichiki H, Okamoto M, Kawayama T, Yodoi J, Kato S, Aizawa H.
- Journal Title
  
  Biochem Biophys Res Commun 354
  
  Pages: 712-719
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Excision repair cross-complementation group 1 predicts progression-free and overall survival in non-small cell lung cancer patients treated with platinum-based chemotherapy.2007
- Author(s)
  Azuma K, Komohara Y, Sasada T, Terazaki Y, Ikeda J, Hoshino T, Itoh K, Yamada A, Aizawa H.
- Journal Title
  
  Cancer science. 98
  
  Pages: 1336-1343
- NAID
  10019998325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390244
[Journal Article] Redox regulation of lung inflammation by thioredoxin2005
- Author(s)
  Nakamura, T., Nakamura, H., Hoshino, T., Ueda, S., Wada, H., Yodoi, J
- Journal Title
  
  Antioxid Redox Signal 7
  
  Pages: 60-71
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] IL-182005
- Author(s)
  星野友昭
- Journal Title
  
  サイトカイン・増殖因子用語ライブラリー(菅村和夫、宮園貢平浩平、宮澤恵二、田中伸幸編)
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma2005
- Author(s)
  Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S他
- Journal Title
  
  Biochem Biophys Res Commun 334
  
  Pages: 1141-1148
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma.2005
- Author(s)
  Ichiki, H., Hoshino, T., Kinoshita, T., Imaoka, H., Kato, S., Inoue, H., Nakamura, H., Yodoi, J., Young, H.A., Aizawa, H.
- Journal Title
  
  Biochem Biophys Res Commun 334
  
  Pages: 1141-1148
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Redox regulation of lung inflammation by thioredoxin.2005
- Author(s)
  Nakamura, T., H.Nakamura, T.Hoshino, S.Ueda, H.Wada, J.Yodoi.
- Journal Title
  
  Antioxid Redox Signal 7
  
  Pages: 60-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Redox regulation of lung inflammation by thioredoxin2005
- Author(s)
  Nakamura, T., Nakamura, H., Hoshino, T., Ueda, S., Wada, H., Yodoi, J
- Journal Title
  
  Antioxid Redox Signal 7
  
  Pages: 60-71
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma.2005
- Author(s)
  Ichiki, H., Hoshino, T., Kinoshita, T., Imaoka, H., Kato, S., Inoue, H., Nakamura, H., Yodoi, J., Young, H.A., Aizawa, H.
- Journal Title
  
  Biochem Biophys Res Commun, 334
  
  Pages: 1141-1148
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Redox regulation of lung inflammation by thioredoxin2005
- Author(s)
  Nakamura T, Nakamura H, Hoshino T, Ueda S, Wada H, Yodoi J.
- Journal Title
  
  Antioxid Redox Signa 7
  
  Pages: 60-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Related Articles, Links Abstract Thioredoxin suppresses airway hyperre sponsiveness and airway inflammation in asthma.2005
- Author(s)
  Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S, Inoue H, Nakamura H, Yodoi J, Young HA, Aizawa H.
- Journal Title
  
  Biochem Biophys Res Commun 334
  
  Pages: 1141-1148
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma.2005
- Author(s)
  Ichiki, H., T.Hoshino, T.Kinoshita, H.Imaoka, S.Kato, H.Inoue, H.Nakamura, J.Yodoi, H.A.Young, H.Aizawa.
- Journal Title
  
  Biochem Biophys Res Commun 334
  
  Pages: 1141-1148
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390244
[Journal Article] Molecular cloning, chromosomal location, and biological activit of norcine interleukin-21.2004
- Author(s)
  Muneta, Y., Hoshino, T., et al.
- Journal Title
  
  JVet Med Sci 66
  
  Pages: 269-275
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.2004
- Author(s)
  Mastumoto, K., Hoshino, T., et al.
- Journal Title
  
  J Immunol 172
  
  Pages: 2350-2541
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosis.2004
- Author(s)
  Kitasato Y, Hoshino T, Okamoto M, Kato S他
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 619-625
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Limited role for interleukin-18 in the host protection responsetn nulmonary infection with Pseudomonas aernginosa in mice.2004
- Author(s)
  Nakasone, C., Hoshino, T., et al.
- Journal Title
  
  Infect Immun 72
  
  Pages: 6176-6180
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Molecular cloning, chromosomal location, and biological activity of porcine interleukin-212004
- Author(s)
  Muneta Y, Kikuma R, Uenishi H, Hoshino T, Yoshihara K, Tanaka M, Hamashima N, Mori Y.
- Journal Title
  
  J Vet Med Sci 66
  
  Pages: 269-275
- NAID
  110003886393
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Enhanced Expression of IL-18 and its Receptor in Idiopathic Pulmonary Fibrosis.2004
- Author(s)
  Kitasato, Y., Hoshino, T., et al.
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 619-625
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Molecular cloning, chromosomal location, and biological activity of porcine interleukin-21.2004
- Author(s)
  Muneta, Y., Hoshino, T., et al.
- Journal Title
  
  JVet Med Sci 66
  
  Pages: 269-275
- NAID
  110003886393
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.2004
- Author(s)
  Mastumoto, K., Hoshino, T., et al.
- Journal Title
  
  J Immunol 172
  
  Pages: 2530-2541
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Molecular cloning, chromosomal location, and biological activity of porcine interleukin-21.2004
- Author(s)
  Muneta, Y., Hoshino, T., et al.
- Journal Title
  
  J Vet Med Sci 66
  
  Pages: 269-275
- NAID
  110003886393
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Molecular cloning, chromosomal location, and biological activity of norcine interleukin-21.2004
- Author(s)
  Muneta, Y., Hoshino, T., et al.
- Journal Title
  
  JVet Med Sci 66
  
  Pages: 269-275
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Limited role for interleukin-18 in the host protection response to nulmonary infection with Pseudomonas aeruginosa in mice.2004
- Author(s)
  Nakasone, C., Hoshino, T., et al.
- Journal Title
  
  Infect Immun 72
  
  Pages: 6176-6180
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanicm.2004
- Author(s)
  Mastumoto, K., Hoshino, T., et al.
- Journal Title
  
  J Immunol 172
  
  Pages: 2530-2541
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis2004
- Author(s)
  Kitasato Y, Hoshino T, Okamoto M, Kato S, Koda Y, Nagata N, Kinoshita M, Koga H, Yoon DY, Asao H, Ohmoto H, Koga T, Rikimaru T, Aizawa H.
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 619-625
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Limited role for interleukin-18 in the host protection response to pulmonary infection with Psendomonas aeroginosa in mice.2004
- Author(s)
  Nakasone, C., Hoshino, T., et al.
- Journal Title
  
  Infect Immun 72
  
  Pages: 6176-6180
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.2004
- Author(s)
  Nakasone C, Kawakami K, Hoshino T, Kawase Y, Yokota K, Yoshino K, Takeda K, Akira S, Saito A.
- Journal Title
  
  Infect Immun 72
  
  Pages: 6176-6180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Limited role for interleukin-18 in the host protection response to pulmonary infection with Psendomonas aeruginosa in mine.2004
- Author(s)
  Nakasone, C., Hoshino, T., et al.
- Journal Title
  
  Infect Immun 72
  
  Pages: 6176-6180
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism2004
- Author(s)
  Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, Tsushima F, Hoshino T, Aizawa H, Akiba H, Pardoll D, Hara N, Yagita H, Azuma M, Nakanishi Y.
- Journal Title
  
  J Immunol 172
  
  Pages: 2530-2541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosis.2004
- Author(s)
  Eatasato Y, Hoshino T, Okamoto M, Kato S, Koda Y Nagata N, Kinoshita M, Koga H, Yoon DY, Asao H, Ohmoto H, Koga T, Rikimaru T, Aizawa H.
- Journal Title
  
  Am J Resp Cell Mol Biol 31
  
  Pages: 619-625
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590328
[Journal Article] Enhanced Expression of IL-18 and its Receptor in Idiopathic Pulmonary Fibrosis.2004
- Author(s)
  Kitasato, Y., Hoshino, T., et al.
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 619-625
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Enhanced Expression of IL-18 and its Receptor in Idiopathic Pulmonary Fibrosis.2004
- Author(s)
  Kitasato, Y., Hoshino, T., et al.
- Journal Title
  
  Am J Respir Cell Mol Biol 31
  
  Pages: 619-625
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Bone malformations in interleukin-18 transgenic mice.2003
- Author(s)
  Kawase, Y., Hoshino, T., et al.
- Journal Title
  
  J Bone Miner Res 18
  
  Pages: 975-983
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Bone malformations in interleukin-18 transgenic mice2003
- Author(s)
  Kawase Y, Hoshino T, Yokota K, Kuzuhara A, Nakamura M, Maeda Y, Nishiwaki E, Zenmyo M, Hiraoka K, Aizawa H, Yoshino K.
- Journal Title
  
  J Bone Miner Res 18
  
  Pages: 975-983
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.2003
- Author(s)
  Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M.
- Journal Title
  
  J Gastroenterol Hepatol 18
  
  Pages: 960-969
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Bone malformations in interleukin-18 transgenic mice.2003
- Author(s)
  Kawase, Y., Hoshino, T., et al.
- Journal Title
  
  J Bone Miner Res 18
  
  Pages: 975-983
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Bone malformations in interleukin-18 transgenic mice.2003
- Author(s)
  Kawase, Y., Hoshino, T., et al.
- Journal Title
  
  J Bone Miner Res 18
  
  Pages: 975-983
- Data Source
  KAKENHI-PROJECT-16659218
[Journal Article] Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin.2003
- Author(s)
  Kawase Y, Hoshino T, Yokota K, Kuzuhara A, Kirii Y, Nishiwaki E, Maeda Y, Takeda J, Okamoto M, Kato S, Imaizumi T, Aizawa H, Yoshino K
- Journal Title
  
  J Invest Dermatol 121
  
  Pages: 502-509
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin.2003
- Author(s)
  Kawase, Y.Hoshino, T., et al.
- Journal Title
  
  J Invest Dermatol 121
  
  Pages: 502-509
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin.2003
- Author(s)
  Kawase, Y., Hoshino, _T., et al.
- Journal Title
  
  J Invest Dermatol 121
  
  Pages: 502-509
- Data Source
  KAKENHI-PROJECT-16012263
[Journal Article] Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury2003
- Author(s)
  Hoshino T, Nakamura H, Okamoto M, Kato S, Araya S, Nomiyama K, Oizumi K, Young HA, Aizawa H, Yodoi J.
- Journal Title
  
  Am J Respir Crit Care Med 168
  
  Pages: 1075-1083
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin.2003
- Author(s)
  Kawase, Y., Hoshino, T., et al.
- Journal Title
  
  J Invest Dermatol 121
  
  Pages: 502-509
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390261
[Journal Article] Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin.2003
- Author(s)
  Kawase, Y., Hoshino, T., et al.
- Journal Title
  
  J Invest Dermatol 121
  
  Pages: 502-509
- Data Source
  KAKENHI-PROJECT-16659218
[Patent] 間質性肺炎治療薬及び当該疾病動物モデルの作成とスクリーニング方法2003
- Inventor(s)
  星野友昭
- Industrial Property Rights Holder
  星野友昭
- Filing Date
  2003-04-23
- Acquisition Date
  2004-04-02
- Data Source
  KAKENHI-PROJECT-16012263
[Patent] 間質性肺炎治療薬及び当該疾病動物モデルの作成とスクリーニング方法2001
- Inventor(s)
  星野友昭
- Industrial Property Rights Holder
  星野友昭
- Filing Date
  2001-04-23
- Acquisition Date
  2004-04-02
- Data Source
  KAKENHI-PROJECT-16659218
[Presentation] 当科で経験した家族性地中海熱22例の検討2018
- Author(s)
  藤本京子、日高由紀子、林真樹子、杉鈴奈、古賀琢眞、海江田信二郎、星野友昭、山崎聡士、井田弘明
- Organizer
  第62回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-16K09912
[Presentation] 当院における多発血管炎性肉芽腫症に対するリツキシマブ治療効果の検討2018
- Author(s)
  林真樹子、藤本京子、海江田信二郎、吉田裕美、杉　鈴奈、古賀琢眞、日髙由紀子、星野友昭、井田弘明
- Organizer
  第62回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-16K09912
[Presentation] CD163陽性M2マクロファージの関節炎における機能解析と治療への応用2017
- Author(s)
  海江田信二郎　星野友昭
- Organizer
  2017　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K09912
[Presentation] 新規IL-1ファミリーサイトカインIL-38の膠原病疾患における発現および機能解析2016
- Author(s)
  星野友昭
- Organizer
  日本リウマチ学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-25461202
[Presentation] 特発性肺線維症の新規血清バイオマーカーの解析2014
- Author(s)
  岡元　昌樹、藤本　公則、上甲　剛、田尻　守拡、小野　純也、太田　昭一郎、出原　賢治、星野　友昭
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860663
[Presentation] 血清ペリオスチン値は、IPFの長期予後因子である2014
- Author(s)
  岡元　昌樹，藤本　公則, 上甲　　剛，田尻　守拡, 小野　純也, 太田　昭一郎，出原　賢治，星野　友昭
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25860663
[Presentation] Role of proinflammatory cytokines in respiratory diseases.2010
- Author(s)
  Hoshino T
- Organizer
  Joint Meeting of the International Cytokine Society(ICS) and the International Society for Interferon and Cytokine Research (ISICR)
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-21590977

1. YAMADA Akira (50158177)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SHICHIJO Shigeki (30080592)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Kaieda Shinjiro (20330798)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. OIZUMI Kotaro (70006097)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MASAKI Okamoto (50352133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 伊東恭悟 (50125499)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KATO Seiya (60268844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. SEKI Naoko (40226634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOH Uhi (60268901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AIZAWA Hisamichi (90175711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 今井康久 (90268847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中尾真修 (40258447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 片岡明夫 (40194758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOMOHARA yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AZUMA Koishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. Matsuo Norikazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. Sasada Tetsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. KINOSHITA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. AIHARA Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. NORIHO Sakamoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. SHIRAISHI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 相沢久道

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
23. 松尾恵太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 齊藤祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 川山智隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 坂崎優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 三森経世

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 井田弘明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 山口由衣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 太田昭一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 松本久子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 出原賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 二宮一茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSHINO Tomoaki 星野 友昭

Research Projects

Research Products

Co-Researchers

Regulation of IL-18, IL-38 and complements for the treatment of inflammatory pulmonary diseasesPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マスト細胞を介したシェーグレン症候群唾液腺炎メカニズム解析と治療への応用Ongoing

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

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Research Institution

Regulation of IL-18 and IL-38 for the treatment of inflammatory pulmonary diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

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Research Institution

Roles of new cytokine IL-38 in inflammatory diseasesPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Study for roles of inflammatory cells and cytokines in asthma death, COPD and mouse pulmonary disease modelsPrincipal Investigator

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抗癌剤による肺障害の分子機構解析と新規治療薬開発Principal Investigator

Principal Investigator

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Principal Investigator

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Study for roles of proinflammatory cytokine IL-18 and redox signals in the pathogenesis of interstitial lung diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

間質性肺炎の原因遺伝子解明と新規治療薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

HOSHINO Tomoaki 星野友昭