SAEGUSA Makoto 三枝信

Researcher Number	00265711
Affiliation (Current)	2022: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2022: Kitasato University, 医学部, 教授 2008 – 2009: Kitasato University, 医学部, 准教授 2006: Kitasato University, Pathology, Associate Professor, 医学部, 助教授 2003 – 2005: 北里大学, 医学部, 講師 1995 – 2001: 北里大学, 医学部, 講師 1998: 北里大学, 医学部・病理学, 講師
Review Section/Research Field	Principal Investigator Human pathology / Human pathology / Basic Section 49020:Human pathology-related Except Principal Investigator Human pathology / Human pathology / Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 子宮内膜癌 / p53 / β-カテニン / beta-catenin / 子宮癌肉腫 / TCF4 / アポトーシス / p21WAF1 / p14 / bcl-2 … More / CD44 / endometrial carcinoma / 細胞増殖 / Sox4 / 癌幹細胞 / βーカテニン / Beta-catenin / p14ARF / endometrial cancer / p300 / p16 / 子宮内膜癌細胞 / S100A4 / 子宮頚癌 / 分子病理学 / apoptosis / cell proliferation / ER / PR / endometrial corinoma / RT-PCR / menstrual cycle / hormone receptor / 子宮頚部癌 / 卵巣癌 / Endometrial carcinoma / ovarian carcinoma / Uterine cervical carcinoma / Par-4 / Par4 / bc1-2 / 正常子宮内膜 / 月経周期 / Sox遺伝子 / β-カテニン遺伝子 / TCF4遺伝子 / Sox7 / Sox9 / NF-κB / Sox４ / Sox / Slug / EMT / senescence / p21 / p16^<INK4A> / pRb / ミオシン9 / 上皮間葉転換 / MYH9 / NMIIA / 子宮癌肉所 / Myosin / 癌・間質インターラクション / 間質 / S100A1 / MDM2 / 増殖 / 非筋細胞ミオシンII / がん幹細胞 / 子宮がん肉腫 … More Except Principal Investigator アポトーシス / 甲状腺癌 / 細胞増殖 / 甲状腺炎 / 直腸癌 / 卵巣明細胞癌 / thyroiditis / 癌幹細胞ニッチ / 発癌促進作用 / 細胞死 / 自己免疫病 / リンパ球性甲状腺炎 / p53蛋白 / 細胞回転 / 潰瘍性大腸 / 炎症性腸疾患 / 発現 / 炎症 / OLFM4 / olfactomedin-4 / 潰瘍性大腸炎 / 発癌 / olfactmedin 4 / HNF-1beta / NF-kB / bcl2 / HNF-1β / ｂｃｌ－２ / 卵巣子宮内膜症性嚢胞 / 腫瘍分化・増殖様式 / NF-κB / テロメラーゼ / テロメア / 細胞分化 / テロメレーズ / thyroid tumors / telemerase / telemere length / differentiation / cell proliferation / apoptosis / RETがん遺伝子 / Ras遺伝子 / 発がん / thyroid cancer / RET protoncogene / Ras gene / carcinogenesis / 病理診断 / テキストマイニング解析 / 画像解析 / 深層学習法 / 診断支援システム / 病理診断報告書 / 病理組織標本 / テキストマイニング / ディープラーニング（深層学習） / 病理診断支援システム / LEFTY / TGF-beta / Lefty遺伝子 / 卵巣明細胞 / Lefty / Smad2 / バイオマーカー / エキソソーム / 癌幹細胞 / 化学放射線療法 / 上皮間葉転換 / β-カテニン / 化学・放射線療法 / βーカテニン / がん幹細胞 / PD-L1 / NCRT / 癌免疫監視回避機構 / 進行期直腸癌 / PDL1 / PD1 / S100A4 Less

進行期直腸癌のS100A4依存性癌幹細胞ニッチ形成を標的とした新規治療戦略
- Principal Investigator
  
  高橋博之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
子宮がん肉腫のS100A4/NMIIシグナルによるがん肉腫幹細胞化機構の解明Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Association of nuclear beta-catenin and PD1/PDL1 expression with cancer stem niche in advanced rectal cancer
- Principal Investigator
  
  高橋博之
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
S100A4/non-muscle Myosin II Signaling Regulates Epithelial-Mesenchymal Transition and Stemness in Uterine CarcinosarcomaPrincipal Investigator
- Principal Investigator
  
  Saegusa Makoto
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma
- Principal Investigator
  
  Kajita Sajiine
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Application of text mining techniques and image analysis in pathology diagnosis
- Principal Investigator
  
  Hara Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Possible role of nuclear b-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Molecular analysis of cancer stem cells drived from uterine carcinosarcomaPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Transcriptional upregulation of HNF-1beta by NF-kB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression
- Principal Investigator
  
  Kajita Sabine
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Molecular mechanism of OLFM4 and the significance as an inflammatory biomarker and therapeutic target for ulcerative colitis
- Principal Investigator
  
  YOSHIDA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Sox4 functions as a positive regulator of beta-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomasPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A functional role of Par-4 in endometrial tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A role of β-catenin signaling loop on cell proliferation and differentiation of endometrial carcinomas : Implication for gene therapyPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A role of beta-catenin/p53 pathway on tumor cell proliferation and differenatiation of endometrial carcinoma cellsPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Makoto
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮内膜癌、頚癌及び卵巣癌におけるCD44遺伝子発現異常に関与する転写因子の解明Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Promotion effect of lymchocytic thyroiditis in thyroid carcinogenesis by activation of RET protoncogene
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
子宮内膜の癌化及び腫瘍進展過程におけるCD44蛋白発現の果たす役割の解明Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
The role of telomerase activity in thyroid tumorigenesis
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
リンパ球性甲状腺炎における甲状腺発癌促進作用の蛋白・遺伝子異常からの解明
- Principal Investigator
  
  岡安勲
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮体癌の増殖制御機構とBcl-2,Box.蛋白及びホルモンレセプター発現の解析Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
慢性リンパ球性甲状腺炎における甲状腺発癌促進作用の証明
- Principal Investigator
  
  OKAYASU Isao
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
子宮頚癌の発生・進展過程におけるHPV感染とアポトーシスの分子病理学的研究Principal Investigator
- Principal Investigator
  
  三枝信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University

All 2022 2020 2019 2017 2016 2015 2014 2013 2012 2010 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells2022
- Author(s)
  Nakagawa M, Higuchi S, Hashimura M, Oguri Y, Matsumoto T, Yokoi A, Ishibashi Y, Ito T, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 22 Pages: 184-184
- DOI
  10.1186/s12885-022-09249-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07413
[Journal Article] S100A4/non-muscle Myosin II Signaling Regulates Epithelial-Mesenchymal Transition and Stemness in Uterine Carcinosarcoma2020
- Author(s)
  Yokoi Ako、Matsumoto Toshihide、Oguri Yasuko、Hasegawa Yoshinori、Tochimoto Masataka、Nakagawa Mayu、Saegusa Makoto
- Journal Title
  
  Lab Invest
  
  Volume: 18 Pages: 103-103
- DOI
  10.1186/s12964-020-00580-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-17K08703, KAKENHI-PROJECT-17K15654
[Journal Article] S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma2020
- Author(s)
  Hiruta Ai、Oguri Yasuko、Yokoi Ako、Matsumoto Toshihide、Oda Yusuke、Tomohiro Mikihisa、Hashimura Miki、Jiang Zesong、Tochimoto Masataka、Nakagawa Mayu、Saegusa Makoto
- Journal Title
  
  Am J Pathol
  
  Volume: 190 Pages: 2304-2316
- DOI
  10.1016/j.ajpath.2020.07.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-17K08703, KAKENHI-PROJECT-17K15654
[Journal Article] Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.2019
- Author(s)
  Mirura R, Yokoi A, Matsumoto T, Oguri Y, Hashimura M, Tochimoto M, Kajita S, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Pages: 308-308
- DOI
  10.1186/s12885-019-5539-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15250
[Journal Article] Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma2017
- Author(s)
  Akiya M, Yamazaki M, Matsumoto T, Kawashima Y, Oguri Y, Kajita S, Kijima D, Chiba R, Yokoi A, Takahashi H, Kodera Y, Saegusa M.
- Journal Title
  
  Histopathology
  
  Volume: 8 Pages: 227-237
- DOI
  10.18632/oncotarget.18882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15250, KAKENHI-PROJECT-17K19926, KAKENHI-PROJECT-17H02206, KAKENHI-PROJECT-15K08385
[Journal Article] Possible role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer2017
- Author(s)
  Hiroyuki Takahashi, Kie Nakamura, Akane Usami, Tomoko Tsuruta, Miki Hashimura, Toshihide Matsumoto, Makoto Saegusa
- Journal Title
  
  Histopathology
  
  Volume: 印刷中
- DOI
  10.1111/his.13227
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08385
[Journal Article] Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma2016
- Author(s)
  Inoue H , Takahashi H, Hashimura M, Eshima K, Akiya M, Matsumoto T, Saegusa M
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Pages: 53-53
- DOI
  10.1186/s12885-016-2090-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460427
[Journal Article] Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression.2015
- Author(s)
  Suzuki E, Kajita S, Takahashi H, Matsumoto T, Tsuruta T, Saegusa M.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 95 Pages: 962-972
- DOI
  10.1038/labinvest.2015.73
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670179
[Journal Article] Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus.2014
- Author(s)
  Takahashi, H., Yoshida, T., Matsumoto, T., Kameda, Y., Takano, Y., Tazo, Y., Inoue, H, Saegusa, M.
- Journal Title
  
  Hum Pathol.
  
  Volume: 45 Pages: 33-40
- DOI
  10.1016/j.humpath.2013.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590452, KAKENHI-PROJECT-24790361
[Journal Article] Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor B/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas.2013
- Author(s)
  Yoshida T, Hashimura M, Kuwata T, Matsumoto T, Suzuki E, Tazo Y, Nakajima H, Inukai M, Saegusa M.
- Journal Title
  
  Human Pathology
  
  Volume: 44 Pages: 1780-1788
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells.2013
- Author(s)
  Yoshida, T., Hashimura, M., Matsumoto, T., Tazo, Y., Inoue, H., Kuwata, T., Saegusa, M.
- Journal Title
  
  Lab Invest
  
  Volume: 93 Pages: 1184-1193
- DOI
  10.1038/labinvest.2013.111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590452
[Journal Article] Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor B/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas.2013
- Author(s)
  Yoshida T, Hashimura M, Kuwata T, Matsmoto T, Suzuki E, Tazo Y, Nakajima H, Inukai M, Saegusa M
- Journal Title
  
  Hum Pathol
  
  Volume: 44 Pages: 1780-1788
- DOI
  10.1016/j.humpath.2012.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415, KAKENHI-PROJECT-24590452
[Journal Article] Transcriptional up-regulation of Sox9 by NF-κB in endometrial carcinoma cells, modulating cell proliferation through alteration in the p14^<ARF>/p53/p21^<WAF1>pathway2012
- Author(s)
  Saegusa M, Hashimura M, Suzuki E, Yoshida T, Kuwata T
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Pages: 684-692
- DOI
  10.1016/j.ajpath.2012.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Sox4 functions as a positive regulator ofβ-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas2012
- Author(s)
  Saegusa M, Hashimura M, Kuwata T
- Journal Title
  
  Lab Invest
  
  Volume: 92 Pages: 511-521
- DOI
  10.1038/labinvest.2011.196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590415
[Journal Article] Transcriptional regulation of pro-apoptotic Par-4 by NF-kB/p65 and its function in controlling cell kinetics during early events in endometrial tumorigenesis.2010
- Author(s)
  Saegusa M, Hashimura M, Kuwata T, Okayasu I.
- Journal Title
  
  J Pathol 221
  
  Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590352
[Journal Article] Transcriptional regulation of pro-apoptotis Par4 by NF-κB/p65 and its function in controlling cell kinetics during early events in endometrial tumorigenesis2010
- Author(s)
  Saegusa M, et al
- Journal Title
  
  Journal of Pathology
  
  Volume: 221 Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590352
[Journal Article] Induction of p16^<INK4A> mediated by p-catenin in a TCF4-independent manner: Implication for alteration in p16^<INK4A> and pRb expression2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Induction of p16INK4A mediated by β-catenin in a TCF4-independent manner : Implication for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Induction of p16 mediated by β-catenin in a TCF4-independent manner : Implication for alterations in p16 and pRb expression2006
- Author(s)
  Saegusa M et al.
- Journal Title
  
  International Journal of Cancer 119
  
  Pages: 2294-2303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as transcriptional target of β-catenin/p300 complexes2005
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as a transcriptional target Ofβ-catenin/p300 complexes2005
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] Upregulation of TCF4 expression as a transcriptional target of β-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells2005
- Author(s)
  Saegusa M, et al.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 768-779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590315
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cylin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa M et al.
- Journal Title
  
  Am J Pathol 164
  
  Pages: 1739-1749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590313
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa M et al.
- Journal Title
  
  American Journal of Pathology 164
  
  Pages: 1739-1749
- Data Source
  KAKENHI-PROJECT-15590313
[Journal Article] β-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cylin D1 during squamous differentiation of endometrial carcinoma cells2004
- Author(s)
  Saegusa m et al.
- Journal Title
  
  American Journal of Pathology 164
  
  Pages: 1739-1749
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590313
[Presentation] 子宮癌肉腫のS100A4/非筋細胞ミオシンII系による肉腫成分誘導機構の解明2020
- Author(s)
  栃本　昌孝, 三枝信
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08703
[Presentation] 深層学習による病理自動診断　病理医不要の日は近い！？2017
- Author(s)
  原　敦子、石橋優一、三枝　信
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08386
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2017
- Author(s)
  高橋博之，橋村美紀，松本俊英，三枝信
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] The role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in rectal carcinoma2017
- Author(s)
  高橋博之、橋村美紀、松本俊英、三枝信
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 進行期直腸癌のβ-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2016
- Author(s)
  高橋博之、宇佐美茜、千葉理紗子、橋村美紀、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] Sox4/β-カテニン/p300/Slug系は上皮間葉転換/がん幹細胞化を介して子宮癌肉腫の肉腫成分形成に関与する2016
- Author(s)
  橋村美紀、高橋博之、井上久子、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460427
[Presentation] 電子化標本画像解析による客観的病理診断のモデル化2016
- Author(s)
  原　敦子、石橋雄一、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台（国際センター）
- Data Source
  KAKENHI-PROJECT-15K08386
[Presentation] 卵巣明細胞腺癌の発癌・進展過程におけるLeftyの機能解析2016
- Author(s)
  秋谷昌史、山崎真瑛、松本俊英、梶田咲美乃、三枝信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16K15250
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2015
- Author(s)
  高橋博之、中村貴恵、鶴田智子、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 炎症バイオマーカーolfactomedin 4の発現からみた炎症性腸疾患の病因病態.2015
- Author(s)
  横田　章、吉田　功、大熊拓也、橋口　収、三上哲夫、徳山　宣、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 潰瘍性大腸炎におけるバイオマーカーolfactomedin 4の発現機序.2015
- Author(s)
  橋口　収、吉田　功、大熊拓也、横田　章、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 潰瘍性大腸炎バイオマーカーolfactomedin 4の機能同定とその意義.2015
- Author(s)
  大熊拓也、吉田　功、橋口　収、横田　章、岡安　勲、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] NF-κB/Sox9によるCol2A1遺伝子発現制御を介した子宮内膜癌肉腫細胞の軟骨分化誘導機構2013
- Author(s)
  橋村美紀, 三枝信, 他
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox4はβ-カテニン/TCF4シグナル伝達系と協調して子宮内膜癌細胞の増殖制御・転位分化を促進する2012
- Author(s)
  三枝　信、橋村美紀、桑田健
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox4は, β-カテニン/TCF4シグナル伝達系と協調して子宮内膜癌細胞の増殖制御・転位分化を促進する2012
- Author(s)
  三枝信, 他
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] アポトーシス関連遺伝子Par-4による子宮内膜細胞動態調節機構と発癌2010
- Author(s)
  三枝信, 他
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-20590352
[Presentation] アポトーシス関連遺伝子Par-4 による子宮内膜細胞動態調節機構と発癌2010
- Author(s)
  三枝信、橋村美紀、桑田健、岡安勲
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590352
[Presentation] 潰瘍性大腸炎腫瘍発生における炎症性バイオマーカーOLFM4の役割
- Author(s)
  吉田功、山本渚、横田章、大熊拓也、岡安勲、三枝信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 炎症性腸疾患バイオマーカーOLFM4発現調節と潰瘍性大腸炎・クローン病の疾患特異性.
- Author(s)
  横田章、吉田功、山本渚、岡安勲、三枝信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 卵巣明細胞腺癌におけるHNF-1β/NF-κB系の機能解析
- Author(s)
  鈴木エリ奈、梶田咲美乃、三枝　信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場他（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25670179
[Presentation] NF-kB/Sox9によるCol2A1遺伝子発現制御を介した子宮癌肉腫細胞の軟骨分化誘導機構
- Author(s)
  橋村美紀、田雑有紀、中島裕康、原　敦子、吉田　功、三枝　信
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] Sox9によるp14ARF/p53/p21waf1系を介した子宮内膜癌細胞の増殖制御機構
- Author(s)
  三枝　信、犬飼　円、鈴木エリ奈、山本　渚、西　達也、松本俊英、桑田　健
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590415
[Presentation] 潰瘍性大腸炎におけるOLFM4発現誘導機序の解明とその意義.
- Author(s)
  山本渚、吉田功、横田章、岡安勲、三枝信
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590452
[Presentation] 卵巣明細胞癌におけるHNF-β発現の機能解析とその臨床的意義について
- Author(s)
  鈴木エリ奈、梶田咲美乃、鶴田智子、三枝信
- Organizer
  第102回　日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25670179

1. OKAYASU Isao (20014342)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. Takahashi Hiroyuki (60377330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. Kajita Sabine (60194734)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. MIKAMI Tetuo (90286352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Tsutomu (90316943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. Hara Atsuko (10276123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. Ishibashi Yuichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Hashimura Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. Nakamura Kie

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. Usami Akane

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 松本俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 小寺義男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAEGUSA Makoto 三枝 信

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子宮がん肉腫のS100A4/NMIIシグナルによるがん肉腫幹細胞化機構の解明Principal Investigator

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S100A4/non-muscle Myosin II Signaling Regulates Epithelial-Mesenchymal Transition and Stemness in Uterine CarcinosarcomaPrincipal Investigator

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Molecular analysis of cancer stem cells drived from uterine carcinosarcomaPrincipal Investigator

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Sox4 functions as a positive regulator of beta-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomasPrincipal Investigator

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A functional role of Par-4 in endometrial tumorigenesisPrincipal Investigator

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A role of β-catenin signaling loop on cell proliferation and differentiation of endometrial carcinomas : Implication for gene therapyPrincipal Investigator

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A role of beta-catenin/p53 pathway on tumor cell proliferation and differenatiation of endometrial carcinoma cellsPrincipal Investigator

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SAEGUSA Makoto 三枝信