YAMAGUCHI Masahiko 山口真彦

Researcher Number	00266149
Other IDs
Affiliation (based on the past Project Information) *help	2002 – 2004: Dokkyo University School of Medicine, Professor, 医学部, 教授 1996 – 2001: Showa University Fujigaoka Hospital, Faculty of Medicine, Assistant Professor, 医学部, 講師 2000: 昭和大, 医学部, 講師 1995 – 1997: 昭和大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery / General surgery Except Principal Investigator Digestive surgery / General surgery
Keywords	Principal Investigator IGF-1 / hepatocyte growth factor / HGF / ICAM-1 / アデノウイルスベクター / intestinal epithelial regeneration / gene transfer / Massive bowel resection / 腸上皮再生 / 遺伝子導入 … More / 腸管大量切除 / ecdothelial seeding / hepatectomy / reconstruction of IVC / 内皮化 / 肝切除 / 下大静脈再建 / Insulin / liver regeneration / adenovirus vector / 脾自家移植 / 肝傷害 / インスリン / 肝再生 / Vascular endothelial cells / Adenovirus vector / Antisense therapy / PDGF-A鎖 / 血管内皮細胞 / アンチセンス … More Except Principal Investigator N-acetylcysteine / fulminant hepatic failure / α-glutathione-S-transferase / 細胞接着 / エンドトキシン / 好中球 / Dextran sulfate / Adhesion / Selectin / HUVEC / Neutrophils / Endotoxin / 抗炎症効果 / 糖鎖薬剤 / デキストラン硫酸 / 接着 / セレクチン / ヒト臍帯静脈内皮細胞 / auxiliary temporal partial orthotopic liver transplantation / anti-intercellular adhesion molecule / reduced glutathione / choline-methionine deficient diet / α-glutathione S transferase / hepatocellular oxidative stress / ヒアルロン酸 / neutrophil oxidative stress / mitochondrial oxidative stress / 還元型グルタチオン / 抗 ICAM1 モノクローナル抗体 / N-acetlcysteine / α-glutatione S transferase / 補助的一時的部分同所性肝移植 / コリン・メチオニン欠乏食 / 激症肝不全 / Vascular endothelial cell / Insulin / gene transfer / Adenovirus vector / Vascular reconstruction / ヘパリン様グリコサミノグリカン / 接着分子 / 再潅流障害 / 内皮下人工血管 / 膵全摘 / 糖尿病 / インスリン / 遺伝子導入 / アデノウイルスベクター / 門脈下大静脈再建 / 肝組織血流量 / 外科的手術侵襲 / ミトコンドリア活性酵素障害 / 閉塞性黄疸 / 細胞内カルシウム反応 / lipopolysaccharide / 流れ / 細胞内Ca2+濃度 / 血管内皮細胞 / 肝硬変 / 肝癌 / 脈管合併切除・再建 / グリソン浸潤 / マイクロ波凝固壊死療法 Less

Research on treatments after maasive bowel resection : Effects of IGF-1 gene transferPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Dokkyo University School of Medicine
Experimental study for reconstruction of portal vein and inferior vena cava in liver surgeryPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Dokkyo University School of Medicine
  Showa University
Research on gene transfer of hepatocyte growth factor in hepato-spleno-surgeryPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
閉塞性黄疸外科的侵襲時の病態解析と治療法の研究：実験と臨床応用についての検討
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
肝硬変合併癌に対する開腹下マイクロ波凝固法の研究 -肝腫瘍外科におけるマイクロ波凝固法の応用は血管合併切除再建に変わりうるか-
- Principal Investigator
  
  KUMADA Kaoru
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Showa University
重篤な術後合併症の対策に関する若干の実験的研究:-白血球接着による血管内皮細胞活性化の制御について-
- Principal Investigator
  
  池田忠明
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Showa University
Effects of heparin-like glycosaminoglycans on postoperative complications
- Principal Investigator
  
  SANADA Yutaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Showa University
Research for investigating treatment of fulnilnant hepatic failure : An experimental study of auxiliary temporal partial orthotopic liver transplantation using living-donor partial liver
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University
Experimental research about the treatment for postoperative pathological changes : control of endothelial activation using antisense adenovirus vectorPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Masahiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Showa University
Experimental analysis for reconsruction of inferior vena cava and portal vein in abdominal surgery : endothelial seeding on artificial grafts and insulin gene transfer into endothelial cells.
- Principal Investigator
  
  KUMADA Kaoru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Showa University

All 2004 2003

All Journal Article

[Journal Article] Secondary resistance to imatinib mesylate in a case of unresectable duodenal GIST without mutations in exon 9,11,13,or 17 of c-kit proto-oncogene2004
- Author(s)
  Masahiko Yamaguchi, Tadashi Matsumoto, Genshu Tate, Takakazu Higuchi
- Journal Title
  
  Journal of Gastroenterology 39
  
  Pages: 904-905
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] 膵嚢胞性疾患に対する脾臓温存膵体尾部切除2004
- Author(s)
  山口真彦, 廣瀬清貴, 中村哲郎
- Journal Title
  
  手術 58・5
  
  Pages: 695-698
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] 胸腔鏡下にて切除し得た食道粘膜下腫瘍の1症例2004
- Author(s)
  高橋修平, 中村哲郎, 山口真彦
- Journal Title
  
  手術 58・2
  
  Pages: 261-264
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] 切除不能の消化管間質系腫瘍(GIST)に対する分子標的治療2004
- Author(s)
  山口真彦
- Journal Title
  
  埼玉県外科医会誌 23
  
  Pages: 53-55
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Secondary resistance to imatinib mesylate in a case of unresectable duodenal GIST without mutations in exon 9,11,13, or 17 of c-kit proto-oncogene2004
- Author(s)
  Masahiko Yamaguchi, Tadashi Matsumoto, Genshu Tate, Takakazu Higuchi
- Journal Title
  
  J Gastroenterol 39・9
  
  Pages: 904-905
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] 巨大ダグラス窩膿瘍を形成した穿孔性虫垂炎の1例2004
- Author(s)
  石橋正樹, 高瀬康雄, 山口真彦
- Journal Title
  
  獨協医学会雑誌 31・3
  
  Pages: 235-238
- NAID
  110004594302
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] micrometastasisの臨床的意義はなにか?2004
- Author(s)
  奥山隆, 川又均, 山口真彦, 藤盛孝博
- Journal Title
  
  Modern Physician 24・1
  
  Pages: 64-68
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Secondary resistance to imatinib mesylate in a case of unresectable duodenal GIST without mutations in exon 9,11,13, or 17 of c-kit proto-oncogene2004
- Author(s)
  Masahiko Yamaguchi, Tadashi Matsumoto, Genshu Tate, Takakazu Higuchi
- Journal Title
  
  Journal of Gastroenterology 39
  
  Pages: 904-905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Budding is useful to select high-risk patients in stage II well-differentiated or moderately differentiated colon adenocarcinoma2003
- Author(s)
  Takashi Okuyama, Tetsuo Nakamura, Masahiko Yamaguchi
- Journal Title
  
  Disear of Colon and Rectum 46
  
  Pages: 1400-1406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Prediction of pancreatic fistula by amylase levels of drainage fluid on the first day after pancreatectomy2003
- Author(s)
  M Yamaguchi, H Nakano, T Midorikawa, Y Yoshizawa, K Kumada
- Journal Title
  
  Hepato-Gastroenterology 50
  
  Pages: 1155-1158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Immunohistochemistry and c-kit gene analysis in determining malignancy in gastrointestinal stromal tumors2003
- Author(s)
  Masahiko Yamaguchi, Genshu Tate, Yutaka Endo, Michiko Miyaki
- Journal Title
  
  Hepato-Gastroenterology 50
  
  Pages: 1431-1435
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Insulin gene transfer with adenovirus vector via the spleen safely and effectively improves posthepatectomized conditions in diabetic rats2003
- Author(s)
  T Matsumoto, M Yamaguchi, M Kuzume, A Matsumiya, K Kumada
- Journal Title
  
  Journal of Surgical Research 110
  
  Pages: 228-234
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Budding is useful to select high-risk patients in stage II well-differentiated or moderately differentiated colon adenocarcinoma2003
- Author(s)
  Takashi Okuyama, Tetsuo Nakamura, Masahiko Yamaguchi
- Journal Title
  
  Disease of Colon and Rectum 46
  
  Pages: 1400-1406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Prediction of pancreatic fistula by amylase levels of drainage fluid on the irst day after pancreatectomy2003
- Author(s)
  M Yamaguchi, H Nakano, T Midorikawa, Y Yoshizawa, K Kumada
- Journal Title
  
  Hepato-Gastroenterology 50
  
  Pages: 1155-1158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591436
[Journal Article] Tumor thrombus in the splenic vein originated from gastric carcinoma that produced alfa-fetoprotein2003
- Author(s)
  M Yamaguchi, T Midorikawa, M Saitoh, S Kadokura, K Miyagawa
- Journal Title
  
  Hepato-Gastroenterology 50
  
  Pages: 1693-1696
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591436

1. KUMADA Kaoru (00025602)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NAKANO Hiroshi (10241035)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 菊地浩彰 (20296966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 緑川武正 (10255797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 池田忠明 (80146844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SORIMACHI Noriko (30217468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKEDA Minoru (50110896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SANADA Yutaka (70103893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UEDA Yoshihiko (50151808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMAGUCHI Masahiko 山口 真彦

Research Projects

Research Products

Co-Researchers

Research on treatments after maasive bowel resection : Effects of IGF-1 gene transferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study for reconstruction of portal vein and inferior vena cava in liver surgeryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on gene transfer of hepatocyte growth factor in hepato-spleno-surgeryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

閉塞性黄疸外科的侵襲時の病態解析と治療法の研究：実験と臨床応用についての検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝硬変合併癌に対する開腹下マイクロ波凝固法の研究 -肝腫瘍外科におけるマイクロ波凝固法の応用は血管合併切除再建に変わりうるか-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

重篤な術後合併症の対策に関する若干の実験的研究:-白血球接着による血管内皮細胞活性化の制御について-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of heparin-like glycosaminoglycans on postoperative complications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for investigating treatment of fulnilnant hepatic failure : An experimental study of auxiliary temporal partial orthotopic liver transplantation using living-donor partial liver

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental research about the treatment for postoperative pathological changes : control of endothelial activation using antisense adenovirus vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental analysis for reconsruction of inferior vena cava and portal vein in abdominal surgery : endothelial seeding on artificial grafts and insulin gene transfer into endothelial cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Secondary resistance to imatinib mesylate in a case of unresectable duodenal GIST without mutations in exon 9,11,13,or 17 of c-kit proto-oncogene2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] 膵嚢胞性疾患に対する脾臓温存膵体尾部切除2004

Author(s)

Journal Title

Data Source

[Journal Article] 胸腔鏡下にて切除し得た食道粘膜下腫瘍の1症例2004

Author(s)

Journal Title

Data Source

[Journal Article] 切除不能の消化管間質系腫瘍(GIST)に対する分子標的治療2004

Author(s)

Journal Title

YAMAGUCHI Masahiko 山口真彦