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OHSAKO Seiichiroh  大迫 誠一郎

… Alternative Names

OHSAKO Seiichiro  大迫 誠一郎

大迫 誠一郎  オオサコ セイイチロウ

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Researcher Number 00274837
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8237-7992
Affiliation (based on the past Project Information) *help 2016 – 2022: 東京大学, 大学院医学系研究科(医学部), 准教授
2011 – 2015: 東京大学, 医学(系)研究科(研究院), 准教授
2008 – 2011: The University of Tokyo, 大学院・医学系研究科, 准教授
2008 – 2010: 東京大学, 大学院・医学(系)研究科, 准教授
2008: 東京大学, 大学院・医学系研究科・疾患生命工学センター, 准教授 … More
2005 – 2006: 東京大学, 大学院医学系研究科, 助教授
2005: 東京大学, 大学院・医学系研究科, 助教授
2002 – 2004: 独立行政法人国立環境研究所, 環境健康研究領域, 主任研究員
2002 – 2003: 国立環境研究所, 分子細胞毒性研究室, 主任研究員
2001: 独立行政法人国立環境研究所, 環境健康研究領域・分子細胞毒性研究室, 主任研究員
2000: 国立環境研究所, 環境健康部, 主任研究員
1998: 国立環境研究所, 環境健康部, 研究員
1996 – 1997: 鹿児島大学, 農学部, 助手 Less
Review Section/Research Field
Principal Investigator
Applied veterinary science / Applied veterinary science / Basic veterinary science/Basic zootechnical science / Basic Section 63030:Chemical substance influence on environment-related / Complex systems / Environmental impact assessment / Hygiene and public health / Basic veterinary science/Basic zootechnical science / Risk sciences of radiation/Chemicals
Except Principal Investigator
Risk sciences of radiation/Chemicals / Applied animal science / Environmental impact assessment/Environmental policy / Science and Engineering
Keywords
Principal Investigator
化学物質 / エピジェネティクス / AhR / 精子発生 / EGFP / CYP1A1 / DNAメチル化 / 尿道下裂 / メチル化 / 環境汚染物質 … More / ダイオキシン / 精細胞 / 抗生物質 / マイクロバイオーム / IL-17A / TH17 / IBD / インフラマソーム / ミクログリア / Nrf2 / Ahr / 認知障害 / 慢性炎症 / プロテオーム / 環境応答 / 新電子性物質 / アクリルアミド / 中枢神経系 / NRF2 / 潰瘍性大腸炎 / Th17 / エピゲノム / AHR / メチル化バイオマーカー / 血液DNA / 次世代環境影響評価 / 包茎 / 血液 / MSD-AFLP / Hepatome / Reporter / ヘパトーマ / レポーター / CYP / 環境化学物質 / バイオマーカー / SRD5A2 / CYP1 / 薬物代謝酵素 / 肝臓 / 進化 / 生殖細胞 / 後世代影響 / P450 / 発がん / DOHaD / 薬剤反応性 / 環境 / 発生・分化 / ゲノム / 有害化学物質 / Reporter assay / Bench Mark Dose / Reporter Assay / 精巣 / 分子シャペロン / 温度感受性 / 転写因子 / HSP90 / 抗体 / マグネシウム / カルネキシン … More
Except Principal Investigator
PCB / Gene expression / Learning performance / Dioxin / Environment / 毒性 / 複合曝露 / 遺伝子プロファイル / TCDD / ポリ塩素化ビフェニル / 社会医学 / 健康影響 / 遺伝子発現 / 学習機能 / ダイオキシン / 環境 / 一日精子産生量 / ステロイド合成酵素遺伝子 / TUNEL法 / Estrogen receptor / Estrogen / Di-n-butyl phthalate / ビメンチンフィラメント / セルトリ細胞 / 精巣内テストステロン濃度 / エストロゲン受容体 / 精巣内テストステロン / estradiol-3-benzoate / ICI 182,780 / di-iso-butyl phthalate / di(n-butyl)phthalate / エストロゲンレセプター / エストロゲン / ステロイドホルモン合成酵素 / テストステロン濃度 / アポトーシス / 精細胞 / Di-iso-butyl phthalate / Di(n-butyl) phthalate / マルチプロファイリング / 化学物質 / 遺伝子発現ネットワーク / レチノイン酸 / マウス胚性幹細胞 / システムバイオロジー / ゲノムネットワーク / 次世代環境影響評価 / 健康影響評価 / 影響評価手法 / 無脊椎動物 / 爬虫類 / 哺乳動物 / 核内受容体 / DNAマイクロアレイ / 内分泌かく乱物質 / 内分泌撹乱物質 / 遺伝子 / 化学物質影響 / 両生類 / 魚類 / マウス Less
  • Research Projects

    (16 results)
  • Research Products

    (167 results)
  • Co-Researchers

    (36 People)
  •  Environmental factors exacerbating IBDPrincipal Investigator

    • Principal Investigator
      大迫 誠一郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63030:Chemical substance influence on environment-related
    • Research Institution
      The University of Tokyo
  •  Biological Response to Environmental Stress: Epigenome/Proteome AnalysisPrincipal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
  •  Application of MSD-AFLP method to explore epigenetic imprints focusing on exposure levels of environmental chemicalsPrincipal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental impact assessment
    • Research Institution
      The University of Tokyo
  •  Relationship between chemical exposure biomarkers and DNA methylation levels in the malformations of external reproductive system of young malesPrincipal Investigator

    • Principal Investigator
      Ohsako Seiichiroh
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hygiene and public health
    • Research Institution
      The University of Tokyo
  •  Epigenetic mutation induced by environmental factors: a molecular mechanism elucidation of the DOHaDPrincipal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of programing of the adaptation to environment: search for the epigenomic modification alteration in the germ linePrincipal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      The University of Tokyo
  •  Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methods

    • Principal Investigator
      KUROHMARU Masamichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied animal science
    • Research Institution
      The University of Tokyo
  •  Postnatal carcinogenic risks of fetal stage exposure to environmental pollutants and its epigenetic molecular mechanismPrincipal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      The University of Tokyo
  •  Development study of the prediction system using mouse ES cells to detect next generation influences

    • Principal Investigator
      SONE Hideko
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental impact assessment/Environmental policy
    • Research Institution
      National Institute for Environmental Studies
  •  Molecular mechanism of intracellular action of modifiers modulating the susceptibility to chemical exposure.Principal Investigator

    • Principal Investigator
      OHSAKO Seiichiroh
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      The University of Tokyo
  •  The profiling of gene expression evoked by co-exposure to dioxin and polychlorinated biphenyl.

    • Principal Investigator
      TOHYAMA Chiharu
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      The University of Tokyo
      National Institute for Environmental Studies
  •  魚類、両生類、哺乳類の不可逆化の臨界期探索

    • Principal Investigator
      井口 泰泉
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Okazaki National Research Institutes
  •  多種哺乳類のAh受容体遺伝子を用いたダイオキシン類の新しい評価法Principal Investigator

    • Principal Investigator
      大迫 誠一郎
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      National Institute for Environmental Studies
  •  哺乳類の妊孕性と精細胞分子シャペロンの機能異常の関係についての研究Principal Investigator

    • Principal Investigator
      大迫 誠一郎
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      National Institute for Environmental Studies
  •  哺乳類雄性生殖細胞の温度感受性に関する分子生物学的解析Principal Investigator

    • Principal Investigator
      大迫 誠一郎
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      National Institute for Environmental Studies
      Kagoshima University
  •  雄性生殖細胞分化過程における分子シャペロンを介したタンパク質輸送の研究Principal Investigator

    • Principal Investigator
      大迫 誠一郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Kagoshima University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] 分子予防環境医学(松島・酒井・遠山ら編)(エピジェネティクスと環境医学)2010

    • Author(s)
      大迫誠一郎
    • Publisher
      本の泉社
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Book] Gene Expression Signatures of Environmental Chemicals in Cancer and in Developmental Disorders. In "XIV Biennial Meeting of the Society for Free Radical Research International"2009

    • Author(s)
      Sone H, Imanishi S, Nagano R, Akanuma H, Fukuda T, Ohsako S.
    • Publisher
      MEDIMOND SRL Publ.
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Book] The roles of free radicals in biology and medicine MEDIMOND SRL Publ.(Gene expression signatures of environmental chemicals in cancer and in developmental disorders.)2009

    • Author(s)
      Sone H, Imanishi S, Akanuma H, Nagano R, Fukuda T, Ohsako S
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Book] 科学(プログラムされる"病"の新たな仮説-環境化学物質による代謝系遺伝子の次世代エピゲノム変化)2009

    • Author(s)
      大迫誠一郎
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Book] Does maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induce glutathione S-transferase-positive hepatic foci in adult rats? In: Morita M. ed., Persistent organic Pollutants (POPS) Research in Asia2008

    • Author(s)
      Sone H, Miyabara Y, Fukuda T, Okura M, Ohsako S, Yonemoto J.
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Book] Morita M.ed., Persistent organic Pollutants (POPS) Research in Asia(Does maternal exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) induce glutathione S- transferase-positive hepatic foci in adult rats?)2008

    • Author(s)
      Sone H, Miyabara Y, Fukuda T, Okura M, Ohsako S, Yonemoto J.
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique2018

    • Author(s)
      Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Ohsako Seiichiroh
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s41021-018-0099-y

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-15H02830
  • [Journal Article] Construction of a High-precision Chemical Prediction System Using Human ESCs2018

    • Author(s)
      山根順子,油谷幸代,今西哲,赤沼宏美,永野麗子,加藤毅,曽根秀子,大迫誠一郎,藤渕航
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 6 Pages: 815-822

    • DOI

      10.1248/yakushi.17-00213-2

    • NAID

      130007382228

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-06-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-15H02830
  • [Journal Article] Expression of xenobiotic biomarkers CYP1 family in preputial tissue of patients with hypospadias and phimosis and its association with DNA methylation level of SRD5A2 minimal promoter.2018

    • Author(s)
      Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K and Kojima Y.
    • Journal Title

      Arch Environ Contam Toxicol.

      Volume: 74 Issue: 2 Pages: 240-247

    • DOI

      10.1007/s00244-017-0466-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08603, KAKENHI-PLANNED-17H06396, KAKENHI-PROJECT-17K11194, KAKENHI-PROJECT-17K11204, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04204, KAKENHI-PROJECT-15H02830
  • [Journal Article] Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end2018

    • Author(s)
      Kurita Hisaka、Aiba Toshiki、Saito Toshiyuki、Ohsako Seiichiroh
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s41021-017-0089-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06396, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-15H02830
  • [Journal Article] Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles2017

    • Author(s)
      Aiba Toshiki、Saito Toshiyuki、Hayashi Akiko、Sato Shinji、Yunokawa Harunobu、Maruyama Toru、Fujibuchi Wataru、Kurita Hisaka、Tohyama Chiharu、Ohsako Seiichiroh
    • Journal Title

      BMC Molecular Biology

      Volume: 18 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s12867-017-0083-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06396, KAKENHI-PROJECT-15H02830, KAKENHI-PROJECT-26670327
  • [Journal Article] Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells.2016

    • Author(s)
      Yamane J, Aburatani S, Imanishi S, Akanuma H, Nagano R, Kato T, Sone H, Ohsako S, Fujibuchi W.
    • Journal Title

      Nucleic Acids Research

      Volume: 44(12) Issue: 12 Pages: 5515-5528

    • DOI

      10.1093/nar/gkw450

    • NAID

      120005763870

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-26670327, KAKENHI-PROJECT-15H02830
  • [Journal Article] Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.2016

    • Author(s)
      Amenya HZ, Tohyama C, Ohsako S.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 34989-34989

    • DOI

      10.1038/srep34989

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670327, KAKENHI-PROJECT-15H02830
  • [Journal Article] A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis.2014

    • Author(s)
      Aida-Yasuoka K, Yoshioka W, Kawaguchi T, Ohsako S, Tohyama C.
    • Journal Title

      Toxicol Sci

      Volume: 141 Issue: 2 Pages: 465-474

    • DOI

      10.1093/toxsci/kfu142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-26670327
  • [Journal Article] Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.2014

    • Author(s)
      Shiizaki K, Ohsako S, Kawanishi M, and Yagi T.
    • Journal Title

      Mol Pharmacol

      Volume: 85 Pages: 279-289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Journal Article] Single administration of butylparaben induces spermatogenic cell apoptosis in prepubertal rats.2014

    • Author(s)
      Alam MS, Ohsako S, Kanai Y, and Kurohmaru M.
    • Journal Title

      Acta Histochemical

      Volume: 116 Pages: 474-480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Journal Article] Single administration of butylparaben induces spermatogenic cell apoptosis in prepubertal rats.2014

    • Author(s)
      Alam MS, Ohsako S, Kanai Y, and Kurohmaru M.
    • Journal Title

      Acta Histochemical

      Volume: 116 Issue: 3 Pages: 474-480

    • DOI

      10.1016/j.acthis.2013.10.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237, KAKENHI-PROJECT-24228005, KAKENHI-PUBLICLY-25132703, KAKENHI-PUBLICLY-26114504
  • [Journal Article] In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet.2014

    • Author(s)
      Sugai E, Yoshioka W, Kakeyama M, Ohsako S. Tohyama C.
    • Journal Title

      J Appl Toxicol

      Volume: 34 Issue: 3 Pages: 296-306

    • DOI

      10.1002/jat.2881

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21671002, KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-26670327
  • [Journal Article] In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet2013

    • Author(s)
      Sugai E, Yoshioka W, Kakeyama M, Ohsako S, and Tohyama C
    • Journal Title

      J Applied Toxicol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Journal Article] Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole : possible determinants for binding putative endogenous ligands2013

    • Author(s)
      Shiizaki K, Ohsako S, Kawanishi M, and Yagi T
    • Journal Title

      Mol Pharmacol

      Volume: 85, 113(published ahead of print) Issue: 2 Pages: 279-289

    • DOI

      10.1124/mol.113.088856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23658237, KAKENHI-PROJECT-26670327
  • [Journal Article] Inference of Gene Regulatory Networks to Detect Toxicity-Specific Effects in Human Embryonic Stem Cells2013

    • Author(s)
      Aburatani S, Fujibuchi W, Yamane J, Nagano R, Sone H, Imanishi S, Ohsako S
    • Journal Title

      Intl J Adv Life Sci

      Volume: v5 n 1&2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Journal Article] Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.2013

    • Author(s)
      Kurita H, Ohsako S, Yoshinaga J, Hashimoto S, and Tohyama C.
    • Journal Title

      J Nutr Biochem

      Volume: 24 Issue: 1 Pages: 256-266

    • DOI

      10.1016/j.jnutbio.2012.05.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237
  • [Journal Article] Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells.2012

    • Author(s)
      He X, Imanishi S, Sone H, Nagano R, Qin X-Y, Yoshinaga J, Akanuma H, Yamane J, Fujibuchi W, and Ohsako S.
    • Journal Title

      Toxicol Lett

      Volume: 212 Issue: 1 Pages: 1-10

    • DOI

      10.1016/j.toxlet.2012.04.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237, KAKENHI-PROJECT-23790150, KAKENHI-PROJECT-23790657
  • [Journal Article] Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice2012

    • Author(s)
      Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C
    • Journal Title

      Toxicol. Sci

      Volume: 127(2) Issue: 2 Pages: 547-554

    • DOI

      10.1093/toxsci/kfs115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390036, KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237, KAKENHI-PROJECT-24590582, KAKENHI-PUBLICLY-23116515
  • [Journal Article] Multi-parametric profiling network based on gene expression and phenotype data : A novel approach to developmental neurotoxicity testing2012

    • Author(s)
      Nagano R., Akanuma H., Qin X-Y., Imanishi S., Toyoshiba H., Yoshinaga J., Ohsako S., Sone H.
    • Journal Title

      International Journal of Molecular Science

      Volume: 13 Issue: 1 Pages: 187-207

    • DOI

      10.3390/ijms13010187

    • NAID

      130005009157

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237
  • [Journal Article] Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis2012

    • Author(s)
      Qin XY, Akanuma H, Wei F, Nagano R, Zeng Q, Imanishi S, Ohsako S, Yoshinaga J, Yonemoto J, Tanokura M, Sone H
    • Journal Title

      Neurotoxicology

      Volume: 33 Issue: 5 Pages: 1375-1380

    • DOI

      10.1016/j.neuro.2012.08.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23228003, KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237
  • [Journal Article] Identification of stage-specific gene expression signatures in response to retinoic acid during the neural differentiation of mouse embryonic stem cells.2012

    • Author(s)
      Akanuma H, Qin XY, Nagano R, Win-Shwe TT, Imanishi S, Zaha H, Yoshinaga J, Fukuda T, Ohsako S, and Sone H.
    • Journal Title

      Front Genet

      Volume: 3 Pages: 141-141

    • DOI

      10.3389/fgene.2012.00141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Journal Article] Perinatal Exposure to Environmental Chemicals Induces Epigenomic Changes in Offspring2011

    • Author(s)
      Ohsako S
    • Journal Title

      Genes and Environment

      Volume: 33 Issue: 2 Pages: 43-49

    • DOI

      10.3123/jemsge.33.43

    • NAID

      10028110787

    • ISSN
      1880-7046, 1880-7062
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-23658237
  • [Journal Article] Perinatal exposure to environmental chemicals induce epigenomic changes in offspring.2011

    • Author(s)
      Ohsako S.
    • Journal Title

      Genes and Environment

      Volume: 掲載確定(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Di(n-butyl) phthalate induces vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis.2010

    • Author(s)
      Alam MS., Ohsako S., Tay TW., Tsunekawa N., Kanai N., Kurohmaru M.
    • Journal Title

      Anatomia Histologia Embryologia

      Volume: 39 Pages: 189-193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di(n-butyl) phthalate2010

    • Author(s)
      Alam, M. S., Ohsako, S., Matsuwaki, T., Zhu, X. B., Tsunekawa, N., Kanai, Y., Sone, H., Tohyama, C. and Kurohmaru, M.
    • Journal Title

      Reproduction

      Volume: Vol.139 Pages: 427-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Journal Article] Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.2010

    • Author(s)
      Ohsako S., Fukuzawa N., Ishimura R., Kawakami T., Wu Q., Nagano R., Zaha H., Sone H., Yonemoto J., Tohyama C.
    • Journal Title

      Biol Reprod 82

      Pages: 636-643

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease : In the spermatozoa stage or at fertilization?2010

    • Author(s)
      Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
    • Journal Title

      Reprod Toxicol 29

      Pages: 68-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Di(n-butyl) phthalate induces vimentin filaments disruption in rat Sertoli cells : a possible relation with spermatogenic cell apoptosis2010

    • Author(s)
      Alam, M.S., Ohsako, S., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
    • Journal Title

      Anatomia, Histologia, Embryologia

      Volume: 39 Pages: 186-193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl)phthalate2010

    • Author(s)
      Alam, M.S., Ohsako, S., Matsuwaki, T., Zhu, X.O., Tsunekawa, N., Kanai, Y., Sone, H., Tohyama, C., Kurohmaru, M.
    • Journal Title

      Reproduction 139

      Pages: 427-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Journal Article] Di(n-butyl)phthalate induces vimentin filaments disruption in rat Sertoli cells : a possible relation with spermatogenic cell apoptosis2010

    • Author(s)
      Alam, M.S., Ohsako, S., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
    • Journal Title

      Anatomia, Histologia, Embryologia (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di (n-butyl) phthalate.2010

    • Author(s)
      Alam MS., Ohsako S., Matsuwaki T., Zhu XB., Tsunekawa N., Kanai Y., Sone H., Tohyama C., Kurohmaru M.
    • Journal Title

      Reproduction 139

      Pages: 427-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di(n-butyl) phthalate.2010

    • Author(s)
      Alam MS., Ohsako S., Matsuwaki T., Zhu XB., Tsunekawa N., Kanai Y., Sone H., Tohyama C., Kurohmaru M.
    • Journal Title

      Reproduction

      Volume: 139 Pages: 427-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di(n-butyl)phthalate.2010

    • Author(s)
      Alam MS., Ohsako S., Matsuwaki T., Zhu XB., Tsunekawa N., Kanai Y., Sone H., Tohyama C., Kurohmaru M.
    • Journal Title

      Reproduction 139

      Pages: 427-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Di(n-butyl) phthalate induce vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis2010

    • Author(s)
      Alam, M. S., Ohsako, S., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
    • Journal Title

      Anat. Histol. Embryol

      Volume: Vol.39 Pages: 186-193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Journal Article] Profiles of Chemical Effects on Cells(pCEC) : a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals.2010

    • Author(s)
      Sone H, Okura M, Zaha H, Fujibuchi W, Taniguchi T, Akanuma H, Nagano R, Ohsako S, Yonemoto J.
    • Journal Title

      J Toxicol Sci 35

      Pages: 115-123

    • NAID

      10025983541

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.2010

    • Author(s)
      Ohsako S., Fukuzawa N., Ishimura R., Kawakami T., Wu Q., Nagano R., Zaha H., Sone H., Yonemoto J., Tohyama C.
    • Journal Title

      Biol Reprod (in press)(印刷中, 掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Di (n-butyl) phthalate induces vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis.2010

    • Author(s)
      Alam MS., Ohsako S., Tay TW., Tsunekawa N., Kanai N., Kurohmaru M.
    • Journal Title

      Anatomia Histologia Embryologia 39

      Pages: 189-193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)exposure decrease : In the spermatozoa stage or at fertilization?2010

    • Author(s)
      Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
    • Journal Title

      Reprod Toxicol 29

      Pages: 68-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Di(n-butyl)phthalate induces vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis.2010

    • Author(s)
      Alam MS., Ohsako S., Tay TW., Tsunekawa N., Kanai N., Kurohmaru M.
    • Journal Title

      Anatomia Histologia Embryologia (in press)(印刷中,掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Gene expression signatures of environmental chemicals in cancer and in developmental disorders.2010

    • Author(s)
      Sone H, Imanishi S, Akanuma H, Nagano R, Fukuda T, Ohsako S.
    • Journal Title

      In "The roles of free radicals in biology and medicine", MEDIMOND SRL Publ.

      Pages: 45-52

    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.2010

    • Author(s)
      Ohsako S., Fukuzawa N., Ishimura R., Kawakami T., Wu Q., Nagano R., Zaha H., Sone H., Yonemoto J., Tohyama C.
    • Journal Title

      Biology of Reproduction

      Volume: 82 Pages: 636-643

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Profiles of Chemical Effects on Cells (pCEC) : a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals.2010

    • Author(s)
      Sone H, Okura M, Zaha H, Fujibuchi W, Taniguchi T, Akanuma H, Nagano R, Ohsako S, Yonemoto J.
    • Journal Title

      J Toxicol Sci 35

      Pages: 115-123

    • NAID

      10025983541

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo p-dioxin (TCDD) exposure decrease : In the spermatozoa stage or at fertilization?2010

    • Author(s)
      Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Namnori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
    • Journal Title

      Reproductive Toxicology

      Volume: 29 Pages: 68-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Dioxin-induced toxicity on vascular remodeling of the placenta.2009

    • Author(s)
      Ishimura R, Kawakami T, Ohsako S, and Tohyama C.
    • Journal Title

      Biochemical Pharmacol 77

      Pages: 660-669

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article]2009

    • Author(s)
      大迫誠一郎
    • Journal Title

      科学「プログラムされる"病"の新たな仮説-環境化学物質による代謝系遺伝子の次世代エピゲノム変化」(岩波書店)

      Pages: 984-988

    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Dioxin-induced toxicity on vascular remodeling of the placenta.2009

    • Author(s)
      Ishimura R, Kawakami T, Ohsako S, Tohyama C.
    • Journal Title

      Biochemical Pharmacol 77

      Pages: 660-669

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Possible Involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.2009

    • Author(s)
      Kawakami T, Ito T, Ohsako S, Shiizakia K, Murakami Y, Hirowatarid K, Sato M, and Tohva C.
    • Journal Title

      J Toxicol Sci 34

      Pages: 209-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Possible Involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.2009

    • Author(s)
      Kawakami T, Ito T, Ohsako S, Shiizakia K, Murakami Y, Hirowatarid K, Sato M, Tohyama C.
    • Journal Title

      J Toxicol Sci 34

      Pages: 209-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYPlAl activity in human and mouse hepatoma cells.2008

    • Author(s)
      Shiizaki K, Ohsako S, Kawanishi M, and Yagi T.
    • Journal Title

      Basic Clinical Pharmacol Toxicol 103

      Pages: 468-475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Differences in gene expression and benzo[a]-pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2, 3, 7,8-tetrachlorodibenzo-p-dioxin and/or benzo [a]pyrene.2008

    • Author(s)
      Wu Q., Suzuki J.S., Zaha H., Lin T-M., Peterson R.E., Tohyama C., Ohsako S.
    • Journal Title

      J Appl Toxicol 28

      Pages: 724-733

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Omeprazole alleviates benzo[a]-pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.2008

    • Author(s)
      Shiizaki K, Ohsako S, Kawanishi M, Yagi T.
    • Journal Title

      Basic Clinical Pharmacol Toxicol 103

      Pages: 468-475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007

    • Author(s)
      Sakata Y., Yoshioka W, Tohyama C., Ohsako S.
    • Journal Title

      Biochem Biophys Res Comm 355

      Pages: 687-692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide2007

    • Author(s)
      Sakata Y., Yoshioka W., Tohyama C., Ohsako S.
    • Journal Title

      Biochem Biophys Res Comm 355

      Pages: 687-692

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Internal genomic sequence of human CYPIAI gene is involved in superinduction of dioxin-induced CYPIAI transcription by cycloheximide2007

    • Author(s)
      Sakata Y., Yoshioka W., Tohyama C., Ohsako S.
    • Journal Title

      Biochem Biophys Res Comm 355

      Pages: 687-692

    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007

    • Author(s)
      Sakata Y., Yoshioka W., Tohyama C., Ohsako S.
    • Journal Title

      Biochem Biophys Res Comm 355

      Pages: 687-692

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007

    • Author(s)
      Sakata Y, Yoshioka W, tohyama C, Ohsako S.
    • Journal Title

      Biochem Biophys Res Comm 355

      Pages: 687-692

    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Differential susceptibilities of Holzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin(TCDD)despite the identical primary structure of the aryl hydrocarbon receptor.2006

    • Author(s)
      Kawakami T, Ishimura R, Nohara K, Takeda K, Tohyama C, Ohsako S.
    • Journal Title

      Toxicol Appl Pharmacol 212

      Pages: 224-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006

    • Author(s)
      Kawakami T., Ishimura R., Nohara K., Takeda K., Tohyama, C., Ohsako, S.
    • Journal Title

      Tox.Appl.Pharmacol. 212

      Pages: 224-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006

    • Author(s)
      Kawakami T., Ishimura R., Nohara K., Takeda K., Tohyama C., Ohsako S.
    • Journal Title

      Tox. Appl. Pharmacol. 212

      Pages: 224-236

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin(TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006

    • Author(s)
      Kawakami T., Ishimura R., Nohara K., Takeda K., Tohyama C., Ohsako S.
    • Journal Title

      Toxicol Appl Pharmacol 212

      Pages: 224-236

    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006

    • Author(s)
      Kawakami T, Ishimura R, Nohara K, Takeda K, Tohyama C, Ohsako S
    • Journal Title

      Toxicol Appl Pharmacol 212

      Pages: 224-236

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006

    • Author(s)
      Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
    • Journal Title

      Toxicol. Sci. 225

      Pages: 204-213

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo -p- dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006

    • Author(s)
      Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
    • Journal Title

      Toxicol.Sci. 91

      Pages: 265-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo -p- dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006

    • Author(s)
      Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
    • Journal Title

      Toxicol. Sci. 91

      Pages: 265-274

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatome cell line SK-HEP-1 to dioxin.2005

    • Author(s)
      Shiizaki K, Ohsako S, Koyama T, Nagata R, Yonemoto J, Tohyama C
    • Journal Title

      Toxicol Lett 160

      Pages: 22-33

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SKHEP-1 to dioxin.2005

    • Author(s)
      Shiizaki K., Ohsako, S., Koyama, T., Nagata R., Yonemoto, J., Tohyama, C.
    • Journal Title

      Toxicol.Lett. 160

      Pages: 22-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatome cell line SK-HEP-1 to dioxin.2005

    • Author(s)
      Shiizaki K., Ohsako S., Koyama T., Nagata R., Yonemoto J., Tohyama C.
    • Journal Title

      Toxicol Lett 160

      Pages: 22-33

    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatome cell line SK-HEP-1 to dioxin.2005

    • Author(s)
      Shiizaki K, Ohsako S, Koyama T, Nagata R, Yonemoto J, Tohyama C.
    • Journal Title

      Toxicol Lett 160

      Pages: 22-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17580274
  • [Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SKHEP-1 to dioxin.2005

    • Author(s)
      Shiizaki K., Ohsako S., Koyama T., Nagata R., Yonemoto J., Tohyama C.
    • Journal Title

      Toxicol. Lett. 160

      Pages: 22-33

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-diosin (TCDD) in the mouse.2004

    • Author(s)
      Fukuzawa N.H., Ohsako S., Wu Q., Sakaue M., Fujii-Kuriyama Y, Baba T., Tohyama C.
    • Journal Title

      Mol.Cell.Endocrinol. 221(1-2)

      Pages: 87-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2.2004

    • Author(s)
      Wu Q., Ohsako S., Ishimura R., Suzuki JS., Tohyama C.
    • Journal Title

      Biol 70 70

      Pages: 1790-1797

    • Data Source
      KAKENHI-PROJECT-14760209
  • [Journal Article] Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2.2004

    • Author(s)
      Wu Q., Ohsako S., Ishimura R., Suzuki J.S., Tohyama C.
    • Journal Title

      Biol.Reproduction 70

      Pages: 1790-1797

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-diosin (TCDD) in the mouse.2004

    • Author(s)
      Fukuzawa N.H., Ohsako S., Wu Q., Sakaue M., Fujii-Kuriyama Y, Baba T., Tohyama C.
    • Journal Title

      Mol. Cell. Endocrinol. 221

      Pages: 87-96

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Aryl-hydrocarbon receptor mediated down-regulation of cytochrome P450 side chain cleavage enzyme expression in the adult male mice testis.2004

    • Author(s)
      FUkuzawa H.N., Ohsako S., Kakaue M., Baba T., Tohyama C.
    • Journal Title

      Mol Cell Endocrinol 221

      Pages: 87-96

    • Data Source
      KAKENHI-PROJECT-14760209
  • [Journal Article] Comparative uterine gene expression analysis after dioxin and estradiol administration.2004

    • Author(s)
      Watanabe H., Suzuki1 A., Goto M., Ohsako S., Tohyama C., Handa H., Iguchi1 T.
    • Journal Title

      J Molecular Endocrinol 33

      Pages: 763-771

    • Data Source
      KAKENHI-PROJECT-14760209
  • [Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse2004

    • Author(s)
      Fukuzawa NH, Ohsako S, Wu Q, Sakaue M, Fujii-Kuriyama Y, Baba T, Tohyama C.
    • Journal Title

      Mol. Cell. Endocrinol. 221・1-2

      Pages: 87-96

    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2.2004

    • Author(s)
      Wu Q., Ohsako S., Ishimura R., Suzuki J.S., Tohyama C.
    • Journal Title

      Biol. Reproduction 70

      Pages: 1790-1797

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15201014
  • [Journal Article] Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat.2003

    • Author(s)
      Kubota K., Ohsako S., Kurosawa S., Takeda K., Wu Q., Sakaue M., Kawakami T., Ishimura R., Tohyama C.
    • Journal Title

      J Reprod Dev 49

      Pages: 403-412

    • NAID

      10026620050

    • Data Source
      KAKENHI-PROJECT-14760209
  • [Journal Article] Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide.2003

    • Author(s)
      Ohsako S., Kubota K., Kurosawa S., Takeda K., Wu Q., Ishimura R., Tohyama C.
    • Journal Title

      J Reprod Dev 49

      Pages: 275-290

    • NAID

      10026619475

    • Data Source
      KAKENHI-PROJECT-14760209
  • [Journal Article] Perinatal exposure to environmental chemicals induces epigenomic changes in offspring.

    • Author(s)
      Ohsako S.
    • Journal Title

      Genes Environ 印刷中(掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Patent] CpGメチル化頻度の変動をゲノムワイドに比較解析するためのDNA試料作成方法2010

    • Inventor(s)
      大迫誠一郎、栗田尚佳
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Patent] CpGメチル化頻度の変動をゲノムワイドに比較解析するためのDNA試料作成方法2010

    • Inventor(s)
      大迫誠一郎, 栗田尚佳
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-03-04
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Patent] 胎生プログラミングに対する影響を評価するための方法2009

    • Inventor(s)
      曽根秀子、永野麗子、大迫誠一郎、宮崎航、今西哲、赤沼宏美
    • Industrial Property Rights Holder
      国立環境研究所
    • Industrial Property Number
      2009-081497
    • Filing Date
      2009-03-30
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Presentation] 生殖器異常を呈した新生男児ヒューマンサンプルを用いた曝露推定とエピゲノム解析2018

    • Author(s)
      大迫誠一郎
    • Organizer
      第88 回日本衛生学会学術総会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] ソフトな親電子性物質アクリルアミドの中枢神経毒性におけるミクログリアの役割2018

    • Author(s)
      長谷川莉慧霞、 宗才、 漆谷真、 大迫誠一郎、 櫻井敏博、 市原学
    • Organizer
      第17回分子予防環境医学研究会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] 男児生殖器異常症とエピゲノム変化:MSD-AFLP法を用いたパイロット研究.2018

    • Author(s)
      相場俊樹、林昭子、齋藤俊行、佐藤伸司、湯野川春信、深見真紀、林祐太郎、水野健太郎、小島祥敬、大迫誠一郎.
    • Organizer
      第89回日本衛生学会
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] 低用量ビスフェノールAの胎仔期曝露はマウス海馬のエピゲノムを変化させるかもしれない.2018

    • Author(s)
      相場俊樹、栗田尚佳、齋藤俊行、大迫誠一郎.
    • Organizer
      第47回日本環境変異原学会
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] 低用量ビスフェノールAの胎仔期曝露はマウス海馬のエピゲノムを変化させるかもしれない.2018

    • Author(s)
      大迫誠一郎、栗田尚佳、齋藤俊行、相場俊樹.
    • Organizer
      第18回分子予防環境医学研究会
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] Role of Microglia Activation and Neuroinflammation in Neurotoxicity of Acrylamide, an Environmental Soft Electrophile2018

    • Author(s)
      R. Hasegawa, C. Zong, M. Urushitani, T. Sakurai, S. Ohsako, G. Ichihara
    • Organizer
      Society of Toxicology 57th Annual Meeting (SOT2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] ソフトな親電子性物質アクリルアミドの中枢神経毒性におけるミクログリアの役割2018

    • Author(s)
      長谷川莉慧霞、宗才、漆谷真、大迫誠一郎、櫻井敏博、市原学
    • Organizer
      第88 回日本衛生学会学術総会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] アクリルアミドの中枢神経毒性における神経炎症の役割2018

    • Author(s)
      長谷川莉慧霞, 宗才, 漆谷真, 大迫誠一郎, 櫻井敏博, 市原学
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] ヒトES細胞を用いた高精度の化合物予測システムの構築.2017

    • Author(s)
      山根順子、油谷幸代、今西哲、赤沼宏美、永野麗子、加藤毅、曽根秀子、大迫誠一郎、藤渕航.
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] MSD-AFLP法の臨床サンプル解析への応用.2017

    • Author(s)
      相場俊樹, 齋藤俊行, 林昭子, 佐藤信治, 湯ノ川春信, 大迫誠一郎.
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本市国際会館
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] マウスES細胞を用いた胎児期神経分化モデルにおけるアクリルアミド曝露の影響2017

    • Author(s)
      若山優里奈, 市原学, 櫻井敏博, 大迫誠一郎
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] アクリルアミド中枢神経毒性における神経炎症の役割に関する実験的研究2017

    • Author(s)
      長谷川莉慧霞、宗才、櫻井敏博、大迫誠一郎、市原 学
    • Organizer
      日本産業衛生学会 第45回産業中毒・生物学的モニタリング研究会
    • Data Source
      KAKENHI-PLANNED-17H06396
  • [Presentation] マウスES細胞を用いた胎児期神経分化モデルにおけるアクリルアミド曝露の影響.2017

    • Author(s)
      若山優里奈、市原学、櫻井敏博、大迫誠一郎.
    • Organizer
      第44回日本毒性学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] MSD-AFLP法の臨床サンプル解析への応用.2017

    • Author(s)
      2.相場俊樹, 齋藤俊行, 林昭子, 佐藤信治, 湯ノ川春信, 大迫誠一郎.
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本市国際会館
    • Year and Date
      2017-02-03
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] 17β-ヒドロキシステロイド脱水素酵素2(Hsd17b2)の胎仔・新生児期生殖器におけるAhr-TCDD依存的誘導性.2016

    • Author(s)
      Mohamed Nassef、Sailendra N Sarma、Hesbon Amenya、相場俊樹、秋田英理奈、呉慶、鈴木純子、福澤徳穂、大迫誠一郎.
    • Organizer
      第15回分子予防環境医学研究会
    • Place of Presentation
      自治医科大学(宇都宮市、栃木)
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] Aryl hydrocarbon receptor drives a robust, dioxin-induced epigenetic modulation of the Cyp1a1 promoter.2016

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      第15回分子予防環境医学研究会
    • Place of Presentation
      自治医科大学(栃木県・宇都宮市)
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] 17β-ヒドロキシステロイド脱水素酵素2(Hsd17b2)の胎仔・新生児期生殖器におけるAhr-TCDD依存的誘導性.2016

    • Author(s)
      Mohamed Nassef、Sailendra N Sarma、Hesbon Amenya、相場俊樹、秋田英理奈、呉慶、鈴木純子、福澤徳穂、大迫誠一郎.
    • Organizer
      第15回分子予防環境医学研究会
    • Place of Presentation
      自治医科大学(栃木県・宇都宮市)
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] Aryl hydrocarbon receptor drives a robust, dioxin-induced epigenetic modulation of the Cyp1a1 promoter.2016

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      第15回分子予防環境医学研究会.
    • Place of Presentation
      自治医科大学(宇都宮市、栃木)
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] DNA Hypomethylation of the Cyp1a1 Promoter Region by Short Term Dioxin Exposure.2015

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      第42回日本毒性学会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] Perinatal exposure to dioxins alters the epigenomic program that influences the susceptibility to carcinogens exposed in adulthood.2015

    • Author(s)
      Seiichiroh Ohsako, Hesbon Amenya, Chiharu Tohyama.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju International Convention Center(Jeju, Korea)
    • Year and Date
      2015-06-25
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] Dioxin induces rapid-onset yet durable epigenetic modulation of the Cyp1a1 promoter.2015

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] DNA Hypomethylation of the Cyp1a1 Promoter Region by Short Term Dioxin Exposure.2015

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      第42回日本毒性学会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] Perinatal exposure to dioxins alters the epigenomic program that influences the susceptibility to carcinogens exposed in adulthood.2015

    • Author(s)
      Seiichiroh Ohsako, Hesbon Amenya, Chiharu Tohyama.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju International Convention Center (韓国、チェジュ市)
    • Year and Date
      2015-06-25
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] Dioxin induces rapid-onset yet durable epigenetic modulation of the Cyp1a1 promoter.2015

    • Author(s)
      Hesbon Amanya, Chiharu Tohyama, Seiichiroh Ohsako.
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-08
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] マウスES細胞のダイオキシン曝露におけるin vitro 分化モデルへの影響.2015

    • Author(s)
      佐藤菜乃初、青木札恵、遠山千春、大迫誠一郎.
    • Organizer
      第42回日本毒性学会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-15H02830
  • [Presentation] マウスES細胞のダイオキシン曝露におけるin vitro 分化モデルへの影響.2015

    • Author(s)
      佐藤菜乃初、青木札恵、遠山千春、大迫誠一郎.
    • Organizer
      第42回日本毒性学会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-26670327
  • [Presentation] Dopaminergic neuronal differentiation visualized by human embryonic stem cell-line carrying rat tyrosine hydroxylase-EGFP transgene.2014

    • Author(s)
      Sailendra Nath SARMA, Masanobu KOHDA, Seiichiroh OHSAKO
    • Organizer
      第42回日本毒性学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-07-04
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] Establishment of a unique profiling method for DNA methylation frequency and its application to toxicology.2014

    • Author(s)
      Aiba Toshiki, Saito Toshiyuki, Hayashi Akiko, Sato Shinji, Yunokawa Harunobu, Kurita Hisaka, Maruyama Toru, Fujibuchi Wataru, Tohyama Chiharu, Ohsako Seiichiroh
    • Organizer
      SOT2014
    • Place of Presentation
      Phoenix, Arizona (U.S.A.)
    • Year and Date
      2014-03-27
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] MSD-AFLP法の開発とその応用2014

    • Author(s)
      相場俊樹、齋藤俊行、佐藤信治、湯ノ川春信、栗田尚佳、丸山徹、藤渕航、遠山千春、大迫誠一郎
    • Organizer
      第13回分子予防環境医学研究会
    • Place of Presentation
      和歌山県民文化会館
    • Year and Date
      2014-01-31
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] Prediction of Developmental Neurotoxic Effects using Human Pluripotent Stem Cells2014

    • Author(s)
      Junko Yamane, Sachiyo Aburatani, Satoshi Imanishi, Reiko Nagano, Hideko Sone, Seiichiroh Ohsako, and Wataru Fujibuchi
    • Organizer
      The 7th Takeda Science Foundation Symposium on PharmaSciences iPS Cells in Drug Discovery & Development, International Symposium 2014
    • Place of Presentation
      京都, 京都大学iPS研究所
    • Year and Date
      2014-01-17
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] Generation of the human ES cell line driven by dioxin responsive reporter gene2013

    • Author(s)
      Seiichiroh Ohsako
    • Organizer
      The 11st Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-06-12
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] Effects of Ahr agonist on neuronal cell differentiation from human ES cells.2012

    • Author(s)
      Seiichiroh Ohsako, Junko Yamane, Satoshi Imanishi, Chiharu Tohyama
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 胎生期ダイオキシン曝露による仔のエピゲノム変化の解析2012

    • Author(s)
      青木礼恵,栗田尚佳,遠山千春,大迫誠一郎
    • Organizer
      分子予防環境医学研究
    • Place of Presentation
      倉敷市民会館(岡山県)
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] Effects of 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin in the neuronal differentiation system using human embryonic stem cells2012

    • Author(s)
      Seiichiroh Ohsako, Junko Yamane, Chiharu Tohyama
    • Organizer
      Dioxin2012
    • Place of Presentation
      Carinz, Australia
    • Year and Date
      2012-08-31
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 環境汚染化学物質の周産期曝露による表現型変化―エピジェネティクスと環境毒性学―2012

    • Author(s)
      大迫誠一郎
    • Organizer
      日本獣医学会(招待講演)
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] ヒトES細胞を用いた神経系誘導培養系におけるAhrアゴニストの影響.2012

    • Author(s)
      大迫誠一郎,山根順子,今西哲,遠山千春.
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] 胚性幹細胞試験を用いたメチル水銀の神経発生毒性の影響評価2012

    • Author(s)
      大迫誠一郎, 永野麗子, 何小明, 今西哲, 赤沼宏美, 山根順子, 藤渕航, 曽根秀子
    • Organizer
      日本衛生学会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-03-28
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] 胎生期ダイオキシン曝露による仔のエピゲノム変化の解析2012

    • Author(s)
      青木礼恵, 栗田尚佳, 遠山千春, 大迫誠一郎
    • Organizer
      分子予防環境医学研究
    • Place of Presentation
      倉敷市民会館(岡山県)
    • Year and Date
      2012-01-26
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] Effects of Ahr agonist on neuronal cell differentiation from human ES cells2012

    • Author(s)
      Seiichiroh Ohsako, Junko Yamane, Satoshi Imanishi, Chiharu Tohyama
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2012-06-16
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] ヒトES細胞を用いた神経系誘導培養系におけるAhrアゴニストの影響.2012

    • Author(s)
      大迫誠一郎,山根順子,今西哲,遠山千春.
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] Effects of Ahr agonist on neuronal cell differentiation from human ES cells.2012

    • Author(s)
      Seiichiroh Ohsako, Junko Yamane, Satoshi Imanishi, Chiharu Tohyama
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] ヒトES 細胞を用いた神経系誘導培養系におけるAhr アゴニストの影響2012

    • Author(s)
      大迫誠一郎, 山根順子, 今西哲, 遠山千春
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜, パシフィコ横浜
    • Year and Date
      2012-06-12
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 胚性幹細胞試験を用いたメチル水銀の神経発生毒性の影響評価2012

    • Author(s)
      大迫誠一郎,永野麗子,何小明,今西哲,赤沼宏美,山根順子,藤渕航,曽根秀子
    • Organizer
      日本衛生学会
    • Place of Presentation
      京都大学(京都府)
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 環境汚染化学物質の周産期曝露による表現型変化-エピジェネティクスと環境毒性学-2012

    • Author(s)
      大迫誠一郎
    • Organizer
      日本獣医学会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)(招待講演)
    • Year and Date
      2012-03-28
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] 環境汚染化学物質の周産期曝露による表現型変化-エピジェネティクスと環境毒性学-2012

    • Author(s)
      大迫誠一郎
    • Organizer
      日本獣医学会
    • Place of Presentation
      さいたま, 大宮ソニックシティ
    • Year and Date
      2012-03-28
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 環境汚染物質の胎生期曝露による生後の化学発癌感受性亢進とエピゲノム変化2011

    • Author(s)
      大迫誠一郎
    • Organizer
      日本人類遺伝学会(招待講演)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Data Source
      KAKENHI-PROJECT-23658237
  • [Presentation] 環境汚染物質の胎生期曝露による生後の化学発癌感受性亢進とエピゲノム変化2011

    • Author(s)
      大迫誠一郎
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉県)(招待講演)
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-23310044
  • [Presentation] マウスES細胞を用いた神経系分化系におけるメチル水銀の毒性影響評価.2010

    • Author(s)
      何小明, 永野麗子, 赤沼宏美, 座波ひろ子, 遠山千春, 曽根秀子, 大迫誠一郎.
    • Organizer
      第36回日本トキシコロジー学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] 胎生プログラミング異常を検出するためのマルチプロファイリング技術の確立.2010

    • Author(s)
      赤沼宏美, 永野麗子, 座波ひろ子, 大迫誠一郎, 曽根秀子.
    • Organizer
      第13回日本外因性内分泌撹乱化学物質学会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2010-12-16
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] マウスおよびヒトES細胞を用いた神経分化培養系におけるメチル水銀の毒性影響評価.2010

    • Author(s)
      大迫誠一郎, 永野麗子, 何小明, 今西哲、藤渕航, 赤沼宏美, 曽根秀子.
    • Organizer
      第13回日本外因性内分泌撹乱化学物質学会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2010-12-16
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] ダイオキシンの胎生期曝露による生後の化学発癌感受性亢進とエピゲノム変化.2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第38回日本環境変異原学会
    • Place of Presentation
      静岡テルサ(静岡)
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Di(n-butyl) phthalate (DBP) induces spermatogenic cell apoptosis via estrogen receptor in prepubertal rat testes2009

    • Author(s)
      Mohammad Shah Alam,大迫誠一郎,祝暁波,恒川直樹,金井克晃,九郎丸正道
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-04-03
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] ダイオキシンの胎生期曝露による肝臓エピゲノム変化2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第82回日本生化学会、シンポジウム「化学物質による遺伝子修飾と毒性発現」
    • Place of Presentation
      神戸国際センター、神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Perinatal exposure to dioxins alters the epigenomic program that influences the susceptibility to carcinogens exposed in adulthood.2009

    • Author(s)
      大迫誠一郎
    • Organizer
      Horiba Conference/CDBIM Symposium, 21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl)phthalate2009

    • Author(s)
      Alam, M.S., Ohsako, S., Matsuwaki, T., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
    • Organizer
      21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl) phthalate2009

    • Author(s)
      Alam, M. S., Ohsako, S., Matsuwaki, T., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
    • Organizer
      21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] Di(n-butyl) phthalate(DBP) induces spermatogenic cell apoptosis via estrogen receptor in prepubertal rat testes2009

    • Author(s)
      Mohammad Shah Alam,大迫誠一郎,祝暁波,恒川直樹,金井克晃,九郎丸正道
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      宇都宮
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] Di(n-butyl)phthalate(DBP)induces spermatogenic cell apoptosis via estrogenreceptor in prepubertal rat testes2009

    • Author(s)
      Alam, M.S., Ohsako, S., Tsunekawa, N.Kanai, Y., Kurohmaru, M.
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-04-03
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] 環境汚染物質の胎児期曝露によるゲノムのエピジェネティックな変化2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第79回日本衛生学会 エピジェネティク研究会シンポジム
    • Place of Presentation
      北里大学、東京
    • Year and Date
      2009-03-31
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] 環境汚染物質の胎生期曝露影響は生後の肝臓においてエビジェネティックメモリーとして残る2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第3回日本エビジェネティクス研究会
    • Place of Presentation
      一ツ橋学術総合センタ-(東京)
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Perinatal exposure to dioxins alters the epigenomic program that influences the susceptibility to carcinogens exposed in adulthood.2009

    • Author(s)
      Ohsako S
    • Organizer
      Horiba Conference/CDBIM Symposium, 21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京大学医学部鉄門講堂(東京)
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] 環境汚染物質の胎生期曝露影響は生後の肝臓においてエピジェネティックメモリーとして残る2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第3回日本エピジェネティクス研究会
    • Place of Presentation
      一ツ橋学術総合センター、東京
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] ダイオキシンの胎生期曝露による肝臓エビゲノム変化2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Induction of spermatogeni cell apoptosis in prepubertal rat testes : an estrogeniceffect of di(n-butyl) phthalate and its relationship with testicular steroidogenesis2009

    • Author(s)
      Alam, M. S., Ohsako, S., Tsunekawa, N. K anai, Y., Tohyama, C., Kurohmaru, M.
    • Organizer
      The 3^<rd. Congress of the Asian Association of Veterinary Anatomists
    • Place of Presentation
      Korea
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes : an estrogenic effect of di(n-butyl)phthalate and its relationship with testicular steroidogenesis2009

    • Author(s)
      Alam, M.S., Ohsako, S., Tsunekawa, N.Kanai, Y., Tohyama, C., Kurohmaru, M.
    • Organizer
      The 3^<rd> Congress of the Asian Association of Veterinary Anatomists
    • Place of Presentation
      清州(韓国)
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] ダイオキシンの胎生期曝露による生後の化学発癌感受性亢進とエピゲノム変化2009

    • Author(s)
      大迫誠一郎
    • Organizer
      第38回日本環境変異原学会、シンポジウム「エピジェネティクス-環境変異原研究の新しい展開-」
    • Place of Presentation
      清水テルサ、静岡
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Reduction of methylation frequency in the matured mouse hepatic CYPIA1 promoter region by perinatal dioxin exposure.2009

    • Author(s)
      Ohsako S., Tohyama C
    • Organizer
      The 50^<th> International Congress of Asian Society of Toxicology
    • Place of Presentation
      台北退役軍人病院(Taipci)中国
    • Year and Date
      2009-09-11
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Di-iso-butyl phthalate(DIBP)の精巣毒性における特異性の検討2008

    • Author(s)
      祝暁波,大迫誠一郎, Mohammad Shah Alam,恒川直樹,金井克晃,遠山千春,九郎丸正道
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] Cellular image profiling of neural differentiation pattern of mouse embryonic stem cells with morphological information2008

    • Author(s)
      Nagano R, Shigeru K, Imanishi S, Ohsako S, Zaha H, Ohkura M, Yonemoto J, and Sone H.
    • Organizer
      第41回日本発生生物学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Presentation] ダイオキシンの胎児曝露による遺伝子メチル化の変異2008

    • Author(s)
      大迫誠一郎・菅井恵津子・阪田佳紀・松田佳奈・吉岡亘・掛山正心・遠山千春
    • Organizer
      第35回日本トキシコロジー学会
    • Place of Presentation
      オリンピックセンター、東京
    • Year and Date
      2008-06-28
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] 胎生期ダイオキシン曝露により生じる生後発達の不可逆的変化について2008

    • Author(s)
      大迫誠一郎
    • Organizer
      日本先天異常学会
    • Place of Presentation
      聖路加大学・東京
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Gene Expression Signatures of Environmental Chemicals in Cancer and in Developmental Disorders2008

    • Author(s)
      Sone H, Imanishi S, Nagano R, Akanuma H, Fukuda T, Ohsako S.
    • Organizer
      14th Biennial Meeting of the Society for Free Radical Research International
    • Place of Presentation
      Beijing
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Presentation] マウスES細胞を用いたマルチプロファイリング技術による化学物質の影響評価の開発2008

    • Author(s)
      永野麗子、小池上 繁、今西 哲、赤沼宏美、宮崎 航、大迫誠一郎、黄倉雅広、曽根秀子
    • Organizer
      第11回日本内分泌撹乱化学物質学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18310025
  • [Presentation] 胎生期ダイオキシン曝露により生じる生後発達の不可逆的変化について2008

    • Author(s)
      大迫誠一郎
    • Organizer
      第48回日本先天異常学会
    • Place of Presentation
      聖路加看護大学、東京
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] 胎児期ダイオキシン曝露による生後の組織内ゲノムメチル化の変動2008

    • Author(s)
      大迫誠一郎
    • Organizer
      第19回環境ホルモン学会講演会
    • Place of Presentation
      江戸東京博物館、東京
    • Year and Date
      2008-06-10
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] Di-iso-butyl phthalate(DIBP)の精巣毒性における特異性の検討2008

    • Author(s)
      祝暁波,大迫誠一郎,Mohammad Shah Alam,大迫誠一郎,恒川直樹,金井克晃,遠山千春,九郎丸正道
    • Organizer
      第146回日本獣医学
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-25
    • Data Source
      KAKENHI-PROJECT-20380153
  • [Presentation] 環境汚染化学物質の胎児期曝露によるエピジェネティックな変化2008

    • Author(s)
      大迫誠一郎
    • Organizer
      第52回日本薬学会関東支部会、シンポジウム「環境化学物質の新たな分子標的」
    • Place of Presentation
      東京理科大学、千葉
    • Year and Date
      2008-10-04
    • Data Source
      KAKENHI-PROJECT-20380168
  • [Presentation] A Microarray-Oriented Dioxin-Response Gene Database (DRGdb) Built in the National Institute for Environmental Studies, Japan.2007

    • Author(s)
      Ohsako S, Nishikawa D, Ogi S, Hamada K, Sone H.
    • Organizer
      International Science Forum on Computational Toxicology
    • Place of Presentation
      North Calorina, USA
    • Data Source
      KAKENHI-PROJECT-18310025
  • 1.  TOSHIYUKI Saito (90205667)
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