KUBO Sachiho 久保幸穂

… Alternative Names

久保幸穗クボサチホ

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Researcher Number	00280769
Affiliation (based on the past Project Information) *help	2014: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), その他部局等, その他 2013: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究助手 2012: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 助手 2011: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 2011: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 助手 … More 2010: 東京都健康長寿医療センター研究所, 助手 2009: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 助手 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 助手 2007 – 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 助手 2005 – 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 助手 2004 – 2005: 東京都老人総合研究所, 加齢臓器障害研究グループ, 助手 2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 助手 2003: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所・加齢臓器障害研究グループ, 研究助手 2002: 東京都老人総合研究所, 分子病理部門, 研究員 Less
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Neurology / Human pathology / 細胞死(アポトーシス) / Neurochemistry/Neuropharmacology / Metabolomics / Applied health science
Keywords	Principal Investigator glial cell / aging / astrocyte / neuron / citrullinated protein / arginine / Alzheimer's disease / neurodegenerative disorder / ペプジルアルギニンデイミナーゼ / グリア細胞 … More / 老化 / アストロサイト / ニューロン / シトルリン化蛋白質 / アルギニン / アルツハイマー病 / 神経変性疾患 / AChR / 神経筋シナプス / モデル動物 / MuSK / 重症筋無力症 … More Except Principal Investigator MuSK / agrin / 重症筋無力症 / 神経筋シナプス / AChR / apoptosis / Akt / SMP30 / アポトーシス / myasthenia gravis / 疾患モデル動物 / 筋線維 / 筋萎縮 / arginine / calcium / astrocyte / neuron / citrullinated protein / neurodegenerative disorder / Alzheimer's disease / アルギニン / カルシウム / アストロサイト / ニューロン / シトルリン化蛋白質 / 神経変性疾患 / アルツハイマー病 / neuromusclar junction / muscle-speficik kinase / gluconolactonase / vitamin C / knockout mice / liver / aging / アクチノマイシンD / TNF-α / グルコノラクトナーゼ / ビタミンC / ノックアウトマウス / 肝臓 / 老化 / protein structure / autoimmune disease / neuromuscular junction / acetylcholine receptor / Agrin / 蛋白高次構造 / 自己免疫疾患 / 神経筋シナプス接合部 / アセチルコリンリセプター / 骨格筋線維 / 筋線維タイプ / 代謝変化 / 代謝 / 動物モデル / サルコペニア / IgG4 / プロテアソーム / Th2 / 3,4-DAP / ラパマイシン / muscle-specifc kinase / LRP4 / 疾患モデル / 自己抗体 / 神経細胞栄養因子 / ノックインマウス / 神経筋接合部 / 運動神経細胞 / 逆行性シグナル Less

Elucidation of metabolic shift of skeletal muscle during aging and invention of new therapies for sarcopenia
- Principal Investigator
  
  SHIGEMOTO Kazuhiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Elucidation of pathogenic mechanisms and developing new therapies of myasthenia gravis
- Principal Investigator
  
  SHIGEMOTO KAZUHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Elucidation of the molecular mechanisms of muscle atrophy
- Principal Investigator
  
  SHIGEMOTO Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Analysis of pathogenic mechanisms of myasthenia gravis.Principal Investigator
- Principal Investigator
  
  KUBO Sachiho
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
The elucidation of onset mechanism of Alzheimer's disease.
- Principal Investigator
  
  ISHIGAMI Akihito
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Pathological analysis of abnormal activation for peptidylarginine deiminase in brainPrincipal Investigator
- Principal Investigator
  
  KUBO Sachiho
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Analysis of myasthenic disease caused by MuSK dysfunction
- Principal Investigator
  
  SHIGEMOTO Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Ehime University
The elucidation of the apoptosis inhibitory action of SMP30.
- Principal Investigator
  
  HANDA Setsuko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Analysis of MuSK functions and the molecular pathogenesis of myasthenia gravis with anti-MuSK autoantibodies by proteomic approaches
- Principal Investigator
  
  SHIGEMOTO Kazuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Ehime University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 運動神経細胞とサルコペニア2011
- Author(s)
  重本和宏, 森秀一、宮崎剛、久保幸穂
- Total Pages
  2
- Publisher
  新興医学出版社
- Data Source
  KAKENHI-PROJECT-21200023
[Book] 老年医学update 2010-20112010
- Author(s)
  重本和宏、森秀一、久保幸穂、山田茂、秋好沢諭、宮崎剛
- Total Pages
  184
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-21200023
[Book] Myasthenia gravis Diseas Mechanisms and Immune Intervention-Chaper 17.The Tmmunopathogenesis of Experimental Autoimmune Myasthenia Gravis Induced by Autoantibodies against Muscle-specific kinase2009
- Author(s)
  Shigemoto, K. Kubo, S. Mori. S. Yamada, S. Miyazaki, T. Akiyoshi, T and Maruyama, S.
- Publisher
  Linus Publication, Inc.
- Data Source
  KAKENHI-PROJECT-21200023
[Book] Myasthenia gravis Disease Mechanisms and Immune Intervention.2009
- Author(s)
  Shigemoto, K.Kubo, S.Mori. S.Yamada, S.Miyazaki, T.Akiyoshi, T, Maruyama, S.
- Publisher
  Linus Publication, Inc.
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] RNA analysis of inner ear cells from formalin fixed paraffin embedded (FFPE) archival human temporal bone section using laser microdissection?A technical report2013
- Author(s)
  Kimura Y, Kubo S, Koda H, Shigemoto K, Sawabe M, Kitamura K
- Journal Title
  
  Hear res
  
  Volume: 302 Pages: 26-31
- DOI
  10.1016/j.heares.2013.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592476, KAKENHI-PROJECT-23791953, KAKENHI-PROJECT-24390228, KAKENHI-PROJECT-25670437
[Journal Article] Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis2012
- Author(s)
  Mori, S. , Yamada, S., Kubo, S. , Chen, J., Matsuda, S. , Shudou, M. , Maruyama, N., and Shigemoto, K.
- Journal Title
  
  Journal of neuroimmunology
  
  Volume: 244 Issue: 1-2 Pages: 1-7
- DOI
  10.1016/j.jneuroim.2011.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023, KAKENHI-PROJECT-21591102, KAKENHI-PROJECT-23791009
[Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Hotta H, Desaki J, Kishi M, Konishi T, Nishino Y, Miyazawa A, Maruyama N, Shigemoto K
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 180 Issue: 2 Pages: 617-28
- DOI
  10.1016/j.ajpath.2011.10.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023, KAKENHI-PROJECT-21591102, KAKENHI-PROJECT-21591965, KAKENHI-PROJECT-23592240, KAKENHI-PROJECT-23791009
[Journal Article] 運動トレーニングは老化による神経筋シナプスの変性を予防できるか2012
- Author(s)
  福永大地、久保幸穂、森秀一、宮崎剛、樋上賀一、重本和宏
- Journal Title
  
  健康医科学研究助成論文集
  
  Volume: 27 Pages: 47-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390228
[Journal Article] 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis2012
- Author(s)
  Mori, S. , Kishi, M., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Konishi, T., Maruyama, N., and Shigemoto, K.
- Journal Title
  
  Journal of neuroimmunology
  
  Volume: 245 Issue: 1-2 Pages: 75-78
- DOI
  10.1016/j.jneuroim.2012.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023, KAKENHI-PROJECT-21591102, KAKENHI-PROJECT-21591965, KAKENHI-PROJECT-22591698, KAKENHI-PROJECT-23592240, KAKENHI-PROJECT-23791009, KAKENHI-PROJECT-24390228
[Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Nishino, Y., Miyazawa, A., Maruyama, N., and Shigemoto, K.
- Journal Title
  
  The American journal of pathology
  
  Volume: 180 Pages: 798-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] シナプスを介したサルコペニアの発症メカニズムとバイオマーカー2011
- Author(s)
  重本和宏, 森秀一、宮崎剛、久保幸穂
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 48 Pages: 42-3
- NAID
  10030468993
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] 運動神経細胞とサルコペニア2011
- Author(s)
  重本和宏、森秀一、宮崎剛、久保幸穂
- Journal Title
  
  Modern Physician
  
  Volume: 131,No.11 Pages: 1308-11
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] シナプスを介したサルコペニアの発症メカニズムとバイオマーカー2011
- Author(s)
  重本和宏、森秀一、宮崎剛、久保幸穂
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 48(1) Pages: 42-43
- NAID
  10030468993
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] サルコペニアの発症機構2011
- Author(s)
  重本和宏,森秀一,宮崎剛,久保幸穂
- Journal Title
  
  神経内科
  
  Volume: 75(6) Pages: 584-588
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] サルコペニアの発症機構2011
- Author(s)
  重本和宏, 森秀一、宮崎剛、久保幸穂
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 75 Pages: 584-8
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] Muscle weakness and neuromuscular junction in aging and disease2010
- Author(s)
  Shigemoto, K., Kubo, S., Mori, S., Yamada, S., Akiyoshi, T., Miyazaki, T.
- Journal Title
  
  Geriatr.Gerintol.Int.
  
  Volume: 10
- NAID
  10027273521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] 神経筋接合部の異常と筋萎縮2010
- Author(s)
  重本和宏,森秀一,久保幸穂,山田茂,秋好沢諭,宮崎剛
- Journal Title
  
  メジカルビュー社老年医学
  
  Volume: update 2010-2011 Pages: 135-144
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] Muscle weakness and neuromuscular junctions in aging and disease2010
- Author(s)
  Shigemoto, K., Kubo, S., Mori, S., Yamada, S., Akiyoshi, T., and Miyazaki, T.
- Journal Title
  
  Geriatr Gerontol Int 10 Suppl
  
  Volume: 1 Issue: s1 Pages: 137-147
- DOI
  10.1111/j.1447-0594.2010.00608.x
- NAID
  10027273521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200023, KAKENHI-PROJECT-21591102, KAKENHI-PROJECT-21591965
[Journal Article] 神経筋接合部位の異常と筋力低下2009
- Author(s)
  重本和宏、久保幸穂、丸山直記
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 46(2) Pages: 106-113
- NAID
  10024963928
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] 神経筋接合部位の異常と筋力低下.2009
- Author(s)
  重本和宏、久保幸穂、丸山直記
- Journal Title
  
  日本老年医学会雑誌 46
  
  Pages: 106-113
- NAID
  10024963928
- Data Source
  KAKENHI-PROJECT-21200023
[Journal Article] 神経筋接合部位の異常と筋力低下.2009
- Author(s)
  重本和宏、久保幸穂、丸山直記
- Journal Title
  
  日本老年医学会雑誌 Vol:46, No.2
  
  Pages: 106-113
- NAID
  10024963928
- Data Source
  KAKENHI-PROJECT-19590374
[Journal Article] Myasthenia gravis experimentally induced with muscle-specific kinase2008
- Author(s)
  Shigemoto K. Kubo, S., 他13名2番目
- Journal Title
  
  Ann. N. Y. Acad. Sci. 1132
  
  Pages: 93-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590374
[Journal Article] Myasthenia gravis experimentally induced with muscle-specific kinase.2008
- Author(s)
  Shigemoto, K., Kubo, S., Jie, C., Hato, N., Abe, Y., Ueda, N., Kobayashi, N., Kameda, K., Mominoki, K., Miyazawa, A., et al.
- Journal Title
  
  Ann N Y Acad Sci 1132
  
  Pages: 93-98
- Data Source
  KAKENHI-PROJECT-19590374
[Journal Article] Experimentally induced myasthenia gravis with muscle-specific kinase.2008
- Author(s)
  Shigemoto K., Kubo. S.(他13名)
- Journal Title
  
  Ann.N.U.Acad.Sci.2008. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590374
[Journal Article] Quantitative analysis of mRNA in human temporal bones.2007
- Author(s)
  Kimura, Y., Kubo, S., Koda, H., Noguchi, Y., Sawabe, M., Maruyama, N., and Kitamura, K.
- Journal Title
  
  Acta Otolaryngol 127
  
  Pages: 1024-1030
- Data Source
  KAKENHI-PROJECT-19590374
[Journal Article] Senescence Marker Protein 30 Functions as Gluconolactonase in L-Ascorbic Acid Biosynthesis and Its Knockout Mice Are Prone to Scurvy.2006
- Author(s)
  Kondo Y, Inai Y, Sato Y, Handa S, Kubo S, Shimokado K, Goto S, Nishikimi M, Maruyama N, Ishigami A.
- Journal Title
  
  Proc.Nat.Acad.Sci.USA 103
  
  Pages: 5723-5728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590326
[Journal Article] Accelerated tubular cell senescence in SMP30 knockout mice.2006
- Author(s)
  Yumura, W., Imasawa, T., Suganuma, S., Ishigami. A., Handa, S., Kubo, S. and Maruyama, N.
- Journal Title
  
  Histol. Histopathol. 21
  
  Pages: 1151-1156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590355
[Journal Article] 抗MuSK抗体陽性重症筋無力症の病因と病態2006
- Author(s)
  重本和宏, 久保幸穂, 丸山直記
- Journal Title
  
  基礎老化研究 30
  
  Pages: 25-30
- NAID
  10024377172
- Data Source
  KAKENHI-PROJECT-17590326
[Journal Article] Induction of myasthenia by immunization against muscle-specific kinase.2006
- Author(s)
  Shigemoto K, Kubo S, Maruyama N, Hato N, Yamada H, Jie C, Kobayashi N, Mominoki K, Abe Y, Ueda N, Matsuda S.
- Journal Title
  
  J Clin Invest. 116
  
  Pages: 1016-1024
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590326
[Journal Article] Senescence Marker Protein 30 Functions as Gluconolactonase in L-Ascorbic Acid Biosynthesis and Its Knockout Mice Are Prone to Scurvy.2006
- Author(s)
  Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., and Ishigami, A.
- Journal Title
  
  Proc. Nat. Acad. Sci. USA 103
  
  Pages: 5723-5728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590355
[Journal Article] Senescence Marker Protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.2005
- Author(s)
  Ishigami, A., Fujita, T., Inoue, H., Handa, S., Kubo, S., Kondo, Y., Maruyama, N.
- Journal Title
  
  Cell & Tissue Res. 320
  
  Pages: 243-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate (DFP) in the liver.2004
- Author(s)
  Kondo, Y., Ishigami, A., Kubo, S., Handa, S.et al.
- Journal Title
  
  FEBS Lett. 570
  
  Pages: 57-62
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Senescence marker protein-30 knockout mouse as a novel murine model of senile lung.2004
- Author(s)
  Mori, T., Ishigami, A., Seyama, K., Onai, R., Kubo, S.et al.
- Journal Title
  
  Pathol.Int. 54
  
  Pages: 167-173
- NAID
  10013056213
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Accelerated tubular cell senescence in SMP30 knockout mice.
- Author(s)
  Yumura, W, Imasawa, T., Suganuma, S., Ishigami, A., Handa, S., Kubo, S., Maruyama, N.
- Journal Title
  
  Histol.Histopathol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603010
[Presentation] 抗LRP4抗体による重症筋無力症の動物モデル作成と病態機序の解明2014
- Author(s)
  森秀一、久保幸穂、重本和宏
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] 抗MuSK抗体陽性重症筋無力症の発症に関与する分子機序の解明.2013
- Author(s)
  森秀一、久保幸穂、重本和宏.
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Elucidation of pathogenic mechanism of myasthenia gravis with MuSK antibodies using a novel murine model.2013
- Author(s)
  Mori, S., Kubo, S., Kishi, M., Konishi, T. and Shigemoto, K.
- Organizer
  15th International congress of immunology
- Place of Presentation
  Milano,Italy
- Invited
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Elucidation of pathogenic mechanism of myasthenia gravis with MuSK antibodies using a novel murine model.2013
- Author(s)
  Mori, S., Kubo, S., Kishi, M., Konishi, T. and Shigemoto, K.
- Organizer
  15th International congress of immunology
- Place of Presentation
  Milano,Italy
- Invited
- Data Source
  KAKENHI-PROJECT-25670437
[Presentation] A murine model of myasthenia gravis with MuSK antibodies; effect of genetic background.2013
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. and Shigemoto, K.
- Organizer
  Myasthenia 2013
- Place of Presentation
  Paris,France
- Data Source
  KAKENHI-PROJECT-25670437
[Presentation] A murine model of myasthenia gravis with MuSK antibodies; effect of genetic background.2013
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. and Shigemoto, K.
- Organizer
  Myasthenia 2013
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Ubiquitin-proteasome pathway plays essential roles in maintenance of neuromuscular junctions.2013
- Author(s)
  Mori, S., Yamada, S., Kubo, S., Miyazaki, T. and Shigemoto, K.
- Organizer
  第35回内藤コンファレンス
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25670437
[Presentation] 抗MuSK抗体陽性重症筋無力症の発症に関与する分子機序の解明.2013
- Author(s)
  森秀一、久保幸穂、重本和宏.
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25670437
[Presentation] Ubiquitin-proteasome pathway plays essential roles in maintenance of neuromuscular junctions.2013
- Author(s)
  Mori, S., Yamada, S., Kubo, S., Miyazaki, T. and Shigemoto, K.
- Organizer
  第35回内藤コンファレンス
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Examination of the treatment of myasthenia gravis with anti-MuSK antibodies using an experimental autoimmune animal model.2012
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. Shigemoto, K.
- Organizer
  12th International conference on myasthenia gravis and related disorders
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] A novel murine model of myasthenia gravis with MuSK antibodies.2012
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. Shigemoto, K.
- Organizer
  12th International conference on myasthenia gravis and related disorders
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Examination of the treatment of myasthenia gravis with anti-MuSK antibodies using an experimental autoimmune animal model.2012
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. Shigemoto, K
- Organizer
  9th Japanese-French Symposium for 'muscular dystrophy'
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Divalent and monovalent antibodies lead to dysfunction of MuSK via distinct mechanisms in a rabbit model of myasthenia gravis.2012
- Author(s)
  Mori, S、, Yamada, S., Kubo, S., Chen, J., Matsuda, S., Shudou, M., Maruyama, N. Shigemoto, K.
- Organizer
  9th Japanese-French Symposium for 'muscular dystrophy'
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] A novel murine model of myasthenia gravis with MuSK antibodies2012
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. Shigemoto, K.
- Organizer
  9th Japanese-French Symposium for 'muscular dystrophy'
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Muscle fiber type specific pathology in aging mouse.2012
- Author(s)
  Fukunaga, T., Kubo, S., Mori, S., Miyazaki, T., Higami, Y. dShigemoto, K.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] 老齢マウスの筋線維タイプ特異的な筋萎縮の病態解明2012
- Author(s)
  福永大地、森秀一、久保幸穂、中山亮、村瀬尚哉、宮崎剛、樋上賀一、重本和宏
- Organizer
  日本基礎老化学会第35回大会
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] 抗MuSK抗体陽性重症筋無力症の発症メカニズムに基づく治療薬の検討2012
- Author(s)
  森秀一, 久保幸穂, 岸雅彦, 小西哲郎, 重本和宏
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Effectiveness of 3,4-diaminopyridine to symptomatic treatment of a MuSK antibody-induced mouse model of myasthenia gravis.2012
- Author(s)
  Mori, S., Kubo, S., Akyoshi, T., Yamada, S., Miyazaki, T., Kishi, M. Shigemoto, K.
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] 抗MuSK抗体陽性重症筋無力症の発症メカニズムに基づく治療薬の検討2012
- Author(s)
  森秀一、久保幸穂、岸雅彦、小西哲郎、重本和宏
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390228
[Presentation] Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis2011
- Author(s)
  Mori S, Kubo S, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  第34回日本神経科学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis2011
- Author(s)
  Mori S, Kubo S, Yamada S, Miyazaki T, Shigemoto K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis2011
- Author(s)
  Mori S, Kubo S, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington, D.C.
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] 筋は逆行性シグナルにより筋・運動神経を維持する2010
- Author(s)
  森秀一, 久保幸穂, 秋好沢諭, 山田茂, 宮崎剛, 重本和宏
- Organizer
  第33回日本基礎老化学会大会
- Place of Presentation
  名古屋
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model2010
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  Society for Neuroscience 2010
- Place of Presentation
  San Diego
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] New strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model2010
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Shigemoto, K.
- Organizer
  第33回日本神経科学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model.2010
- Author(s)
  Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Shigemoto, K
- Organizer
  Society for Neuroscience 2010
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] New strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model2010
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  第33回神経科学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Complement activation is dispensable for myasthenia gravis caused by MuSK antibodies2010
- Author(s)
  Shigemoto K, Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T.
- Organizer
  10^<th> International Congress of Neuroimmunology 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Complement activation is dispensable for myasthenia gravis caused by MuSK antibodies.2010
- Author(s)
  Shigemoto, K., Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T
- Organizer
  10^<th> International Congress of Neuroimmunology
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies.2009
- Author(s)
  Mori S, Kubo S, Akivoshi T, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  Society for Neuroscience 2009
- Place of Presentation
  Chicago
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies2009
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Shigemoto K.
- Organizer
  Society for Neuroscience 2009
- Place of Presentation
  Chicago
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] MuSKは神経筋シナプスの維持に重要である～研究モデル動物の確立～2009
- Author(s)
  森秀一, 久保幸穂, 秋好沢諭, 山田茂, 宮崎剛, 重本和宏
- Organizer
  第32回日本基礎老化学会大会
- Place of Presentation
  横浜
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies2009
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Shigemoto K.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies.2009
- Author(s)
  Mori S, Kubo S, Akiyoshi T, Yamada S, Shigemoto K.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21200023
[Presentation] MuSK抗体による重症筋無力症発症の分子メカニズム2008
- Author(s)
  重本和宏、久保幸穂、丸山直記、小西哲郎、太田光煕
- Organizer
  第51回日本神経化学会
- Place of Presentation
  富山
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-19590374
[Presentation] The pathogenic roles of MuSK antibodies in myasthenia gravis.2008
- Author(s)
  K. Shigemoto, S. Kubo, N. Maruyama,J.Chen, M.Ohta, T.Konishi,and S. Matsuda.
- Organizer
  The Society for Neuroscience 38th Annual Meeting.
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-19590374
[Presentation] The pathogenic roles of MuSK antibodies in myasthenia gravis2008
- Author(s)
  K. Shigemoto, S. Kubo, 他
- Organizer
  The Society for Neuroscience 38th Annual Meeting
- Place of Presentation
  アメリカ、ワシントンDC
- Data Source
  KAKENHI-PROJECT-19590374
[Presentation] 神経筋接合部疾患における抗MuSK抗体と病態機序.2007
- Author(s)
  丸山直記, 久保幸穂、重本和宏
- Organizer
  第48回日本神経学会総会シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590374
[Presentation] Fiber specific studies in muscle atrophy with aging mice
- Author(s)
  福永大地、久保幸穂、森秀一、樋上賀一、重本和宏
- Organizer
  第37回日本基礎老化学会
- Place of Presentation
  大府、愛知
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25670437

1. MARUYAM Naoki (00115940)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. SHIGEMOTO Kazuhiro (40284400)

# of Collaborated Projects: 5 results

# of Collaborated Products: 54 results
3. ISHIGAMI Akihiko (50270658)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
4. MIYAZAKI Tsuyoshi (50376480)

# of Collaborated Projects: 2 results

# of Collaborated Products: 38 results
5. HANDA Setsuko (30360697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. YAMADA Shigeru (50508679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
7. MORI Shuuichi (30508677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
8. EDAMATSU Midori (10735343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOSHI Katsuo (20710057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KONISHI Tetsuro (50426508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. MOMINOKI Katsumi (70304615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUDA Seiji (40173843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 喜多村健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBO Sachiho 久保 幸穂

久保 幸穗 クボ サチホ

Research Projects

Research Products

Co-Researchers

Elucidation of metabolic shift of skeletal muscle during aging and invention of new therapies for sarcopenia

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Elucidation of pathogenic mechanisms and developing new therapies of myasthenia gravis

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Elucidation of the molecular mechanisms of muscle atrophy

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Analysis of pathogenic mechanisms of myasthenia gravis.Principal Investigator

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The elucidation of onset mechanism of Alzheimer's disease.

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Pathological analysis of abnormal activation for peptidylarginine deiminase in brainPrincipal Investigator

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Analysis of myasthenic disease caused by MuSK dysfunction

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The elucidation of the apoptosis inhibitory action of SMP30.

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Analysis of MuSK functions and the molecular pathogenesis of myasthenia gravis with anti-MuSK autoantibodies by proteomic approaches

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[Book] 運動神経細胞とサルコペニア2011

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[Book] 老年医学update 2010-20112010

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[Book] Myasthenia gravis Diseas Mechanisms and Immune Intervention-Chaper 17.The Tmmunopathogenesis of Experimental Autoimmune Myasthenia Gravis Induced by Autoantibodies against Muscle-specific kinase2009

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[Book] Myasthenia gravis Disease Mechanisms and Immune Intervention.2009

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[Journal Article] RNA analysis of inner ear cells from formalin fixed paraffin embedded (FFPE) archival human temporal bone section using laser microdissection?A technical report2013

Author(s)

Journal Title

KUBO Sachiho 久保幸穂

久保幸穗クボサチホ