KUMASAKA Toshio 熊坂利夫

Researcher Number	00286709
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: Juntendo University, 医学部, 准教授 2002 – 2006: 順天堂大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator Transforming growth factor-beta / Procollagen mRNA / Silica / ep / Pale ear / HPS-1 / Hermansky-Pudlak syndrome / 胎児線維芽細胞株 / 免疫電顕 / Lysosome … More / Cathepsin L / ep遺伝子 / Hermansky-Pudlak症候群 / TGF-beta / Real time RT-PCR / 胎児線維芽細胞 / Procollagen mRNAs / 肺線維症 / 接着因子 / LAM cell cluster(LCC) / 肺リンパ脈管筋腫症 / 細胞外マトリックス / 細胞接着分子 / リンパ内皮細胞 / リンパ増殖因子 / リンパ脈管筋腫症細胞集塊 / リンパ脈管筋腫症 … More Except Principal Investigator 癌抑制遺伝子 / リンパ管新生 / リンパ脈管筋腫症 / Lymphangiogenesis / Estrogen / Growth inhibitory factor / Growth factor / Primary culture / Tumor suppressor gene / Lymphangioleiomyomatosis / リンパ腫管筋腫症 / 女性ホルモン / 増殖抑制因子 / 増殖因子 / 初代培養 / リンパ行性転移 / 嚢胞性肺疾患 / 自然気胸 / 結節性硬化症 / TSC遺伝子 / がん抑制遺伝子 Less

Elucidation of the mechanism for cell adhesion between LAM cells and lymphatic endothelial cells in the LAM cell clustersPrincipal Investigator
- Principal Investigator
  
  KUMASAKA Toshio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Study on the mechanism of LAM cell proliferation and disease progression in lymphangioleiomyomatosis
- Principal Investigator
  
  SEYAMA Kuniaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Mechanisms of proliferation and metastasis of LAM cells in lymphangioleiomyomatosis (LAM)
- Principal Investigator
  
  SEYAMA Kuniaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Analysis for the function of murine lung fibrosis-related gene, epPrincipal Investigator
- Principal Investigator
  
  KUMASAKA Toshio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  JUNTENDO UNIVERSITY

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Lymphangioleiomyomatosis : In Lymphangiogenesis and Cancer Metastasis2009
- Author(s)
  Seyama K. Kumasaka T, Sato T, Mitani K.
- Publisher
  Springer London(In press)
- Data Source
  KAKENHI-PROJECT-19590406
[Book] Lymphangioleiomyomatosis. Lymphangiogenesis and Cancer Metastasis. Edited by Stacker SA and Achen MG
- Author(s)
  Seyama K. Kumasaka T, Sato T, Mitani K
- Publisher
  Springer London(in press)
- Data Source
  KAKENHI-PROJECT-19590406
[Book] Stacker SD and Achen MG
- Author(s)
  Seyama K, Kumasaka T, Sato T, and Mitani K
- Publisher
  Chapter 8. Lymphangioleiomyomatosis. In : Cancer and lymphatic metastasis
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyomatosis cell clusters found in chylous pleural effusion2007
- Author(s)
  Hirama M, Atsuta R, Mitani K, Kumasaka T, Gunji Y, Sasaki S, Iwase A, Takahashi K, Seyama K
- Journal Title
  
  Intern Med 46
  
  Pages: 1593-6
- NAID
  130000076007
- Data Source
  KAKENHI-PROJECT-19590406
[Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyoma-tosis cell clusters found in chylous pleural effusion2007
- Author(s)
  Hirama M, Atsuta R, Mitani K, Kumasaka T, Gunji Y, Sasaki S, Iwase A, TakahashiK, Seyama K
- Journal Title
  
  Intern Med 46
  
  Pages: 1593-1596
- NAID
  130000076007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] LAMは腫瘍か?2007
- Author(s)
  瀬山邦明, 熊坂利夫ら
- Journal Title
  
  呼吸 26
  
  Pages: 23-30
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis2006
- Author(s)
  Seyama K, Kumasaka T, Souma S, Sato T, Kurihara M, Mitani K, Tominaga S, Fukuchi Y
- Journal Title
  
  Lymphat Res Biol 4
  
  Pages: 143-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] 肺リンパ脈管筋腫症の病理と病態2006
- Author(s)
  熊坂利夫, 瀬山邦明ら
- Journal Title
  
  病理と臨床 24
  
  Pages: 939-948
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] リンパ脈管筋腫症-TSC遺伝子解析からLAMの進展機序への展開-2006
- Author(s)
  瀬山邦明, 熊坂利夫
- Journal Title
  
  二本内科学会雑誌 95
  
  Pages: 1048-1057
- NAID
  10018198718
- Data Source
  KAKENHI-PROJECT-18390243
[Journal Article] Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis.2005
- Author(s)
  Kumasaka T, Seyama K et al.
- Journal Title
  
  American Journal of Surgical Pathology 29
  
  Pages: 1356-1366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590762
[Journal Article] Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis.2005
- Author(s)
  Kumasaka T, Seyama K et al.
- Journal Title
  
  Am J Surg Pathol 29
  
  Pages: 1356-1366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590762
[Journal Article] Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice.2004
- Author(s)
  Yoshioka Y, Kumasaka T, Ishidoh K, Kominami E, Mitani K, Hosokawa Y, Fukuchi Y
- Journal Title
  
  Pathology International 54
  
  Pages: 322-331
- NAID
  10016542813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570200
[Journal Article] Lymphangiogenesis in lymphangioleiomyomatosis : its implication in the progression of lymphangioleiomyomatosis 1007-1016.2004
- Author(s)
  Kumasaka T, Seyama K et al.
- Journal Title
  
  American journal of Surgical Pathology 28
  
  Pages: 1007-1016
- Data Source
  KAKENHI-PROJECT-16590762
[Journal Article] Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice.2004
- Author(s)
  Yoshioka Y, Kumasaka T, Ishidoh K, et al.
- Journal Title
  
  Pathology International 57
  
  Pages: 322-331
- NAID
  10016542813
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570200
[Journal Article] Lymphangiogenesis in lymphangioleiomyomatosis : its implication in the progression of lymphangioleiomyomatosis 1007-1016.2004
- Author(s)
  Kumasaka T, Seyama K et al.
- Journal Title
  
  American Journal of Surgical Pathology 28
  
  Pages: 1007-1016
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590762
[Journal Article] Cytological, Immunocytochemical, and Ultrastructural Characterization of LAM Cell Clusters in the Chylous Effusion of Patients with Lymphangioleiomyomatosis
- Author(s)
  Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K
- Journal Title
  
  ActaCytologica (in press)
- Data Source
  KAKENHI-PROJECT-19590406
[Journal Article] Cytological, immunocytochemical, and ultrastructural characterization of LAM cell clusters in chylous effusion of patients with lymphangioleiomyomatosis
- Author(s)
  Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K
- Journal Title
  
  Acta Cytologica (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390243
[Presentation] 重症リンパ脈管筋腫症における中枢気道の病理学的解析2008
- Author(s)
  熊坂利夫, 三谷恵子, 林大久生, 山鳥一郎, 瀬山邦明
- Organizer
  日本病理学会総会
- Place of Presentation
  金沢
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] 乳糜胸水合併LAM症例における低用量GnRH療法の効果2008
- Author(s)
  郡司陽子, 瀬山邦明, 熊坂利夫, 三谷恵子, 佐藤輝彦, 秋吉妙子, 小池建吾, 高橋和久
- Organizer
  日本呼吸器学会総会
- Place of Presentation
  東京
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] 乳び体腔液中LAM cell cluster (LCC)の細胞学的特徴とその意義2008
- Author(s)
  三谷恵子, 熊坂利夫, 林大久生, 須田耕一, 山鳥一郎, 郡司陽子, 秋吉妙子, 瀬山邦明
- Organizer
  日本呼吸器学会総会
- Place of Presentation
  東京
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] 重症肺リンパ脈管筋腫症における中枢気道障害の病理組織学的解析2008
- Author(s)
  熊坂利夫, 三谷恵子, 林大久生, 山鳥一郎, 瀬山邦明
- Organizer
  日本病理学会総会
- Place of Presentation
  金沢市・おもてなしホール
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] Loss of Heterozygosity of the TSC Genes and Overexpression of mTOR-related Proteins in Multifocal Micronodular Pneumocyte Hyperplasia (MMPH) of the Lung2007
- Author(s)
  Hayashi T, Kumasaka T, Mitani K, Gunji Y, Suda K, Seyama K
- Organizer
  The LAM Foundation 2007 lymphangiogenesis international research conference
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] Cytological, immunocytochemical, and ultrastructual characterization of LAM cell clusters in Chylous Effusion in patients with Lymphangioleiomyomatosis2007
- Author(s)
  Mitani K, Kumasaka K, Takemura H, Hayashi T, Hosokawa Y, Suda K, Gunji Y, Akiyoshi T, Seyama K
- Organizer
  The LAM Foundation 2007 lymphangiogenesis international research conference
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] Effect of long term administration of gonadotropin-releasing hormone analogues on chylous effusion in patients with lymphangioleiomyomatosis2007
- Author(s)
  Seyama K, Sato T, Gunji Y, Kumasaka T, Mitani K, Akiyoshi T, Tobino K, Hayashi T
- Organizer
  LAM Foundation 2007 lymphangiogenesis international research conference
- Data Source
  KAKENHI-PROJECT-19590406
[Presentation] Effect of long term administration of gonadotropin-releasing hormone analogueson chylous effusion in patients with lymphangioleiomyomatosis2007
- Author(s)
  Seyama K, Sato T, Gunji Y, Kumasaka T, Mitani K, Akiyoshi T, Tobino K, Hayashi T
- Organizer
  LAM Foundation2007 International Research Conference
- Place of Presentation
  in Cincinnati USA.
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18390243
[Presentation] Loss of heterozygosity of the TSC genes and overexpression of mTOR-related proteins in multifocalmicronodular pneumocyte hyperplasia of the lung2007
- Author(s)
  Hayashi H, Kumasaka T, Mitani K, Gunji Y, Suda K, Seyama K
- Organizer
  LAM Foundation 2007 International Research Conference
- Place of Presentation
  in Cincinnati USA
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18390243
[Presentation] Cytological, immunocytochemical, and ultrastructual characterization of LAM cell clusters in chylous effusion in patients with lymphangioleiomyomatosis2007
- Author(s)
  Mitani K, Kumasaka T, Takemura H, Hayashi T, Hosokawa Y, Suda K, Gunji Y, Akiyoshi T, Seyama K
- Organizer
  LAM Foundation 2007 International Research Conference
- Place of Presentation
  in Cincinnati USA
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18390243

1. SEYAMA Kuniaki (10226681)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. KODAMA Yuzo (30384069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ISHIDO Kazumi (40212906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. IWAKAMI Shinichiro (80311984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 林大久生

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 三谷恵子

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

KUMASAKA Toshio 熊坂 利夫

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism for cell adhesion between LAM cells and lymphatic endothelial cells in the LAM cell clustersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism of LAM cell proliferation and disease progression in lymphangioleiomyomatosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of proliferation and metastasis of LAM cells in lymphangioleiomyomatosis (LAM)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for the function of murine lung fibrosis-related gene, epPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Lymphangioleiomyomatosis : In Lymphangiogenesis and Cancer Metastasis2009

Author(s)

Publisher

Data Source

[Book] Lymphangioleiomyomatosis. Lymphangiogenesis and Cancer Metastasis. Edited by Stacker SA and Achen MG

Author(s)

Publisher

Data Source

[Book] Stacker SD and Achen MG

Author(s)

Publisher

Data Source

[Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyomatosis cell clusters found in chylous pleural effusion2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyoma-tosis cell clusters found in chylous pleural effusion2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] LAMは腫瘍か?2007

Author(s)

Journal Title

Data Source

[Journal Article] Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis2006

Author(s)

Journal Title

Data Source

[Journal Article] 肺リンパ脈管筋腫症の病理と病態2006

Author(s)

Journal Title

Data Source

[Journal Article] リンパ脈管筋腫症-TSC遺伝子解析からLAMの進展機序への展開-2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice.2004

Author(s)

Journal Title

KUMASAKA Toshio 熊坂利夫