Kanegane Hirokazu 金兼弘和

… Alternative Names

金兼弘和カネガネヒロカズ

KANEGANE Hirokazu 金兼弘和

KANEGANE Hirokzu 金兼弘和

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Researcher Number	00293324
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 寄附講座教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 2018 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 2016 – 2017: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2014 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 2014: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 … More 2008 – 2011: 富山大学, 大学病院, 講師 2006 – 2007: 富山大学, 附属病院, 講師 2001 – 2004: 富山医科薬科大学, 附属病院, 講師 2003: 富山医科薬科大学, 医学部附属病院, 講師 2001: 富山医科薬科大学, 医学附属病院, 講師 1998 – 1999: 富山医科薬科大学, 附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Pediatrics / Experimental pathology / Pediatrics
Keywords	Principal Investigator Flow cytometry / フローサイトメトリー / X連鎖リンパ増殖症候群 / X連鎖無ガンマグロブリン血症 / 原発性免疫不全症 / X-linked agammaglobulinemia / Bruton's tyrosine kinase / 慢性活動性EBウイルス感染症 / EBウイルス / ノックインマウス … More / iPS細胞 / B細胞欠損症 / 好中球減少症 / 先天性免疫異常症 / CTLA4ハプロ不全 / TNFAIP3ハプロ不全 / XIAP欠損症 / A20ハプロ不全症 / 炎症性腸疾患 / 腸内細菌叢 / Genetic analysis / Primary immunodeficiency / East Asia / 遺伝子解析 / X連鎖無γグロブリン血症 / 先天性免疫不全症 / 東アジア / Pro B cells / Pre B cells / B cells / Bone marrow / Agammaglobulinemia / プロB細胞 / プレB細胞 / B細胞 / 骨髄 / 無ガンマグロブリン血症 / Chronic active EBV infection / Dysgammaglobulinemia / Malignant fymphoma / Fatal infectious mononucleosis / SAP gene / Epstein-Barr virus / X-linked lymphoproliferative syndrome / 低γ-グロブリン血症 / 慢性活動性EBV感染症 / 異常ガンマグロブリン血症 / 悪性リンパ腫 / 致死的伝染性単核症 / SAP遺伝子 / IKZF1 / ZAP70 / NRAS / XIAP / SH2D1A / 自己免疫性リンパ増殖症候群 / ブルトンチロシンキナーゼ / Toll様受容体 / 自然免疫 / 抗体産生不全症 / 潜伏感染 / LMP-1 / EBNA-2 / EBNA-1 … More Except Principal Investigator XLA / フローサイトメトリー / 原発性免疫不全症 / XLP / agammaglobulinemia / Btk / 無ガンマグロブリン血症 / ロングリード / 次世代シーケンサー / 診断率向上 / ロングリードシーケンス / 診断困難例 / RNAシーケンス / 全ゲノム解析 / ロングリードNGS / トランスクリプトーム解析 / エクソーム解析 / オミックス解析 / NEMO / プロテオーム / トランスクリプトーム / 全エクソーム解析 / 未診断 / targeted RNA sequence / STAT1 / 未診断症例 / プロテオーム解析 / ターゲットRNAシーケンス / マルチオミックス解析 / rapid diagnosis / international collaboration / monoclonal antibody / flow cytometry / primary immunodeficiency diseases / Igα欠損症 / X連鎖リンパ増殖症候群 / X連鎖無ガンマグロブリン血症 / 簡易診断 / 国際協力 / 単クローン抗体 / 先天性免疫不全症 / B cell defect / pro-B cells / B cells / flow cytometory / immunodeficiency / モノカイン / 単球 / B細胞分化障害 / pro-B細胞 / B細胞 / 先天性免疫不全 / 血球貪食性リンパ組織球症 / サイトカイン / 免疫不全症 / XIAP欠損症 / ヒト化マウス / EBウイルス / IL-7R (CD127) / フローサイトメトー / CD4^+CD25^+CD127^<dim>T細胞 / IL-7R(CD127) / アトピー性皮膚炎 / CD4^+CD25^+T細胞 / FOXP3 / IL-7受容体 / 遺伝子解析 / IPEX / FOXP3遺伝子 / 制御性T細胞 Less

Elucidation of the pathogenesis common to neutropenia and B-cell deficiencyPrincipal Investigator
- Principal Investigator
  
  金兼弘和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Long-read sequencing analysis for difficult to diagnose cases of primary immunodeficiency
- Principal Investigator
  
  岡田賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University
Multi-OMICS approaches to investigate molecular pathogenesis of primary immune deficiency
- Principal Investigator
  
  OKADA SATOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University
Analysis of microbiota and molecular pathogenesis in primary immunodeficiency diseasesPrincipal Investigator
- Principal Investigator
  
  Kanegane Hirokazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University
Establishment of novel diagnosis and analysis of pathogenesis of herediatry lymphoproliferative disordersPrincipal Investigator
- Principal Investigator
  
  Kanegane Hirokazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University
Reproduction of virus-specific immunodeficiency in humanized mice
- Principal Investigator
  
  FUJIWARA Shigeyoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  National Research Institute for Child Health and Development
Study of innate immunity in primary antibody deficiencyPrincipal Investigator
- Principal Investigator
  
  KANEGANE Hirokazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Toyama
Functional maturation of regulatory T cells during child growth and their disorders
- Principal Investigator
  
  MIYAWAKI Toshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Toyama
Establishment of diagnostic system and study of epidemiology of primary immunodeficiency diseases in East AsiaPrincipal Investigator
- Principal Investigator
  
  KANEGANE Hirokazu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Toyama
Studies of B cell development defects inpatients with a gamma globulinemiaPrincipal Investigator
- Principal Investigator
  
  KANEGANE Hirokazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Study on rapid diagnosis of primary immunodeficiency diseases and their abnormalities in immunologic development
- Principal Investigator
  
  MIYAWAKI Toshio
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
SAP gene mutations in Epstein-Barr virus-associated illnesses and study for its pathogenesisPrincipal Investigator
- Principal Investigator
  
  KANEGANE Hirokazu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
慢性活動性EBウイルス感染症におけるEBウイルス関連遺伝子の発現Principal Investigator
- Principal Investigator
  
  金兼弘和
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Toyama Medical and Pharmaceutical University
Study on rapid diagnosis and B cell defect of X-linked agammaglobulinemia
- Principal Investigator
  
  MIYAWAKI Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Toyama Medical and Pharmaceutical University

[Book] 小児科学2023
- Author(s)
  金兼弘和、谷田けい
- Total Pages
  36
- Publisher
  文光堂
- ISBN
  9784830630460
- Data Source
  KAKENHI-PROJECT-22K07887
[Book] 小児血液・腫瘍学2022
- Author(s)
  金兼弘和
- Total Pages
  3
- Publisher
  診断と治療社
- ISBN
  9784787824899
- Data Source
  KAKENHI-PROJECT-22K07887
[Book] 免疫調節障害、小児の発熱AtoZ2012
- Author(s)
  金兼弘和
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 小児の発熱A to Z2012
- Author(s)
  金兼弘和
- Total Pages
  4
- Publisher
  免疫調節障害
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 原発性免疫不全症、「今日の小児治療指針第15版」2012
- Author(s)
  金兼弘和
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 今日の小児治療指針第15版2012
- Author(s)
  金兼弘和
- Total Pages
  2
- Publisher
  原発性免疫不全症
- Data Source
  KAKENHI-PROJECT-21591350
[Book] コロナウイルス、ブニアウイルス、JCウイルス、プリオン、「日常診療に役立つ小児感染症マニュアル2012」2012
- Author(s)
  西田直徳、金兼弘和
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 血液専門医テキスト2011
- Author(s)
  金兼弘和
- Total Pages
  4
- Publisher
  先天性免疫不全症
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 小児科ピクシス24「症状別検査の選び方・進め方」2011
- Author(s)
  金兼弘和
- Total Pages
  4
- Publisher
  易感染、免疫不全
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 先天性免疫不全症、血液専門医テキスト2011
- Author(s)
  金兼弘和
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 免疫不全関連リンパ増殖性疾患、小児がん診療ハンドブック～実地診療に役立つ診断・治療の理念と実践～2011
- Author(s)
  金兼弘和、他
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 小児がん診療ハンドブック～実地診療に役立つ診断・治療の理念と実践～2011
- Author(s)
  金兼弘和、大坪慶輔、野村恵子
- Total Pages
  6
- Publisher
  免疫不全関連リンパ増殖性疾患
- Data Source
  KAKENHI-PROJECT-21591350
[Book] 図解小児科(4章)(免疫・アレルギー・膠原病)(久保田健夫他編)2009
- Author(s)
  金兼弘和
- Publisher
  金芳堂,京都
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Knockdown of the Shwachman-Diamond syndrome gene, SBDS, induces galectin-1 expression and impairs cell growth2024
- Author(s)
  Yamaguchi Masafumi、Sera Yukihiro、Toga-Yamaguchi Hanae、Kanegane Hirokazu、Iguchi Yusuke、Fujimura Kingo
- Journal Title
  
  International Journal of Hematology
  
  Volume: 119 Issue: 4 Pages: 383-391
- DOI
  10.1007/s12185-024-03709-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07887
[Journal Article] Patient-reported outcomes in patients with primary immunodeficiency diseases in Japan: baseline results from a prospective observational study2023
- Author(s)
  Kanegane Hirokazu、Ishimura Masataka、Kawai Toshinao、Okada Satoshi、Okamatsu Nobuaki、Go Madoka、Noto Shinichi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1244250-1244250
- DOI
  10.3389/fimmu.2023.1244250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
[Journal Article] Case Report: Molecular autopsy underlie COVID-19-associated sudden, unexplained child mortality2023
- Author(s)
  Unuma Kana、Tomomasa Dan、Noma Kosuke、Yamamoto Kouhei、Matsuyama Taka-aki、Makino Yohsuke、Hijikata Atsushi、Wen Shuheng、Ogata Tsutomu、Okamoto Nobuhiko、Okada Satoshi、Ohashi Kenichi、Uemura Koichi、Kanegane Hirokazu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1121059-1121059
- DOI
  10.3389/fimmu.2023.1121059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
[Journal Article] Severe RAS-Associated Lymphoproliferative Disease Case with Increasing αβ Double-Negative T Cells with Atypical Features2023
- Author(s)
  Kurita Daisuke、Shiba Norio、Ohya Takashi、Murase Ayako、Shimosato Yuko、Yoshitomi Masahiro、Hattori Seira、Sasaki Koji、Nishimura Kenichi、Tsujimoto Shin-ichi、Takeuchi Masanobu、Tanoshima Reo、Kanegane Hirokazu、Kitagawa Norihiko、Ito Shuichi
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 8 Pages: 1992-1996
- DOI
  10.1007/s10875-023-01566-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07887
[Journal Article] Hematologically important mutations: Leukocyte adhesion deficiency (second update)2023
- Author(s)
  Roos D, van Leeuwen K, Madkaikar M, Kambli PM, Gupta M, Mathews V, Rawat A, Kuhns DB, Holland SM, de Boer M, Kanegane H, Parvaneh N, Lorenz M, Schwarz K, Klein C, Sherkat R, Jafari M, Wolach B, den Dunnen JT, Kuijpers TW, Koker MY
- Journal Title
  
  Blood Cells Mol Dis
  
  Volume: 99 Pages: 102726-102726
- DOI
  10.1016/j.bcmd.2023.102726
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Journal Article] Bone Marrow Failure and Immunodeficiency Associated with Human RAD50 Variants2023
- Author(s)
  Takagi Masatoshi、Hoshino Akihiro、Bousset Kristine、R?ddecke Jule、Martin Hanna Luisa、Folcut Iulia、Tomomasa Dan、Yang Xi、Kobayashi Junya、Sakata Naoki、Yoshida Kenichi、Miyano Satoru、Ogawa Seishi、Kojima Seiji、Morio Tomohiro、D?rk Thilo、Kanegane Hirokazu
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 8 Pages: 2136-2145
- DOI
  10.1007/s10875-023-01591-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-20K12162
[Journal Article] A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis2023
- Author(s)
  Sakura F, Noma K, Asano T, Tanita K, Toyofuku E, Kato K, Tsumura M, Nihira H, Izawa K, Mitsui-Sekinaka K, Konno R, Kawashima Y, Mizoguchi Y, Karakawa S, Hayakawa S, Kawaguchi H, Imai K, Nonoyama S, Yasumi T, Ohnishi H, Kanegane H, Ohara O, Okada S
- Journal Title
  
  PNAS Nexus
  
  Volume: 2 Issue: 4 Pages: 1-12
- DOI
  10.1093/pnasnexus/pgad104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22K15939, KAKENHI-PROJECT-23K24302
[Journal Article] Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function2023
- Author(s)
  Kaneko Shuya、Sakura Fumiaki、Tanita Kay、Shimbo Asami、Nambu Ryusuke、Yoshida Masashi、Umetsu Shuichiro、Inui Ayano、Okada Chizuru、Tsumura Miyuki、Yamada Mamiko、Suzuki Hisato、Kosaki Kenjiro、Ohara Osamu、Shimizu Masaki、Morio Tomohiro、Okada Satoshi、Kanegane Hirokazu
- Journal Title
  
  Immunotherapy Advances
  
  Volume: 3 Issue: 1
- DOI
  10.1093/immadv/ltad027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-23K24302
[Journal Article] Successful treatment of DOCK8 deficiency by allogeneic hematopoietic cell transplantation from alternative donors2023
- Author(s)
  Kono Asuka、Wakamatsu Manabu、Umezawa Yoshihiro、Muramatsu Hideki、Fujiwara Hiroki、Tomomasa Dan、Inoue Kento、Hattori Keiichiro、Mitsui Tetsuo、Takada Hidetoshi、Minegishi Yoshiyuki、Takahashi Yoshiyuki、Yamamoto Masahide、Mori Takehiko、Kanegane Hirokazu
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 4 Pages: 519-525
- DOI
  10.1007/s12185-023-03613-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15316, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-19H03613
[Journal Article] Clinical practice guideline for activated phosphatidyl inositol 3-kinase-delta syndrome in Japan2023
- Author(s)
  Moriya Kunihiko、Mitsui-Sekinaka Kanako、Sekinaka Yujin、Endo Akifumi、Kanegane Hirokazu、Morio Tomohiro、Imai Kohsuke、Nonoyama Shigeaki
- Journal Title
  
  Immunological Medicine
  
  Volume: 46 Issue: 4 Pages: 153-157
- DOI
  10.1080/25785826.2023.2210366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07887
[Journal Article] Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function2023
- Author(s)
  Staines-Boone Aide Tamara、Vignesh Pandiarajan、Tsumura Miyuki、de la Garza Fernandez German、Tyagi Reva、Rawat Amit、Das Jhumki、Tomomasa Dan、Asano Takaki、Hijikata Atsushi、Salazar-Galvez Yuridia、Kanegane Hirokazu、Okada Satoshi、Reyes Saul O Lugo
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 44 Issue: 1 Pages: 20-20
- DOI
  10.1007/s10875-023-01634-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-23K24302
[Journal Article] Recurrent tandem duplication of UNC13D in familial hemophagocytic lymphohistiocytosis type 32022
- Author(s)
  Tomomasa D, Hiejima E, Miyamoto T, Tanita K, Matsuoka M, Niizato D, Mitsuiki N, Isoda T, Yasumi T, van Zelm MC, Morio T, Kanegane H
- Journal Title
  
  Clin Immunol
  
  Volume: 242 Pages: 109104-109104
- DOI
  10.1016/j.clim.2022.109104
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22K15919
[Journal Article] Preemptive hematopoietic cell transplantation for asymptomatic patients with X-linked lymphoproliferative syndrome type 12022
- Author(s)
  Tomomasa D, Booth C, Bleesing JJ, Isoda T, Kobayashi C, Koike K, Taketani T, Sawada A, Tamura A, Marsh RA, Morio T, Gennery AR, Kanegane H
- Journal Title
  
  Clin Immunol
  
  Volume: 237 Pages: 108993-108993
- DOI
  10.1016/j.clim.2022.108993
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Journal Article] Clinical and Genetic Characterization of Patients with Artemis Deficiency in Japan2022
- Author(s)
  Inoue Kento、Miyamoto Satoshi、Tomomasa Dan、Adachi Eriko、Azumi Shohei、Horikoshi Yasuo、Ishihara Takashi、Osone Shinya、Kawahara Yuta、Kudo Ko、Kato Zenichiro、Ohnishi Hidenori、Kashimada Kenichi、Imai Kohsuke、Ohara Osamu、van Zelm Menno C.、Cowan Morton J.、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 3 Pages: 585-594
- DOI
  10.1007/s10875-022-01405-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07841, KAKENHI-PROJECT-22K07887
[Journal Article] Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A202022
- Author(s)
  Toyofuku Etsushi、Takeshita Kozue、Ohnishi Hidenori、Kiridoshi Yuko、Masuoka Hiroaki、Kadowaki Tomonori、Nishikomori Ryuta、Nishimura Kenichi、Kobayashi Chie、Ebato Takasuke、Shigemura Tomonari、Inoue Yuzaburo、Suda Wataru、Hattori Masahira、Morio Tomohiro、Honda Kenya、Kanegane Hirokazu
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 787667-787667
- DOI
  10.3389/fcimb.2021.787667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887
[Journal Article] Novel STAT1 Variants in Japanese Patients with Isolated Mendelian Susceptibility to Mycobacterial Diseases2022
- Author(s)
  Ono R, Tsumura M, Shima S, Matsuda Y, Gotoh K, Miyata Y, Yoto Y, Tomomasa D, Utsumi T, Ohnishi H, Kato Z, Ishiwada N, Ishikawa A, Wada T, Uhara H, Nishikomori R, Hasegawa D, Okada S, Kanegane H.
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 2 Pages: 466-478
- DOI
  10.1007/s10875-022-01396-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07829, KAKENHI-PROJECT-22K07841, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-20K16937, KAKENHI-PROJECT-23K24302
[Journal Article] Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-192022
- Author(s)
  Eto S, Nukui Y, Tsumura M, Nakagama Y, Kashimada K, Mizoguchi Y, Utsumi T, Taniguchi M, Sakura F, Noma K, Yoshida Y, Ohshimo S, Nagashima S, Okamoto K, Endo A, Imai K, Kanegane H, Ohnishi H, Hirata S, Sugiyama E, Shime N, Ito M, Ohge H, Kido Y, Bastard P, Casanova JL, Ohara O, Tanaka J, Morio T, Okada S
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 42 Issue: 7 Pages: 1360-1370
- DOI
  10.1007/s10875-022-01308-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-20K17460, KAKENHI-PROJECT-23K24302
[Journal Article] Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guerin osteomyelitis2022
- Author(s)
  Tomomasa Dan、Tanita Kay、Higashi Seishi、Tasaka Yuri、Shimamura Takashi、Sakurai Urara、Matsubara Tomoyo、Okada Satoshi、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Clinical Immunology
  
  Volume: 235 Pages: 108933-108933
- DOI
  10.1016/j.clim.2022.108933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20J10721, KAKENHI-PROJECT-22K07887
[Journal Article] Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence2022
- Author(s)
  Sbihi Zineb、Tanita Kay、Bachelet Camille、Bole Christine、Jabot-Hanin Fabienne、…Isoda Takeshi（24人中20番目）、…、Kanegane Hirokazu、Latour Sylvain
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 42 Issue: 3 Pages: 559-571
- DOI
  10.1007/s10875-021-01188-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02878, KAKENHI-PROJECT-20J10721, KAKENHI-PROJECT-20K08152, KAKENHI-PROJECT-22K07887
[Journal Article] A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia2022
- Author(s)
  Banday Aaqib Zaffar、Kaur Anit、Akagi Tadayuki et al
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 42 Issue: 7 Pages: 1434-1450
- DOI
  10.1007/s10875-022-01304-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06154, KAKENHI-PROJECT-22K07887
[Journal Article] Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT32021
- Author(s)
  Tanita Kay、Sakura Fumiaki、Nambu Ryusuke、Tsumura Miyuki、Imanaka Yusuke、Ohnishi Hidenori、Kato Zenichiro、Pan Jie、Hoshino Akihiro、Suzuki Koji、Yasutomi Motoko、Umetsu Shuichiro、Okada Chizuru、Takagi Masatoshi、Imai Kohsuke、Ohara Osamu、Muise Alexo M.、Okada Satoshi、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: - Issue: 4 Pages: 780-790
- DOI
  10.1007/s10875-021-00975-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-20J10721
[Journal Article] A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency2021
- Author(s)
  Qin Tao、Jia Yanjun、Liu Yuhang、Dai Rongxin、Zhou Lina、Okada Satoshi、Tsumura Miyuki、Ohnishi Hidenori、Kato Zenichiro、Kanegane Hirokazu、Sun Xiulian、Zhao Xiaodong
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 517544-517544
- DOI
  10.3389/fimmu.2020.517544
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08249, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18KK0228
[Journal Article] Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity2020
- Author(s)
  Okano Tsubasa、Imai Kohsuke、Naruto Takuya、Okada Satoshi、Yamashita Motoi、Yeh Tzu-wen、Ono Shintaro、Tanaka Keisuke、Okamoto Keisuke、Tanita Kay、Matsumoto Kazuaki、Toyofuku Etsushi、Kumaki-Matsumoto Eri、Okamura Miko、Ueno Hiroo、Ogawa Seishi、Ohara Osamu、Takagi Masatoshi、Kanegane Hirokazu、Morio Tomohiro
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 40 Issue: 5 Pages: 729-740
- DOI
  10.1007/s10875-020-00798-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18KK0228
[Journal Article] Impaired B-Cell Differentiation in a Patient With STAT1 Gain-of-Function Mutation.2020
- Author(s)
  Nemoto K, Kawanami T, Hoshina T, Ishimura M, Yamasaki K, Okada S, Kanegane H, Yatera K, Kusuhara K.
- Journal Title
  
  Front Immunol
  
  Volume: 11 Pages: 557521-557521
- DOI
  10.3389/fimmu.2020.557521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08173, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18KK0228
[Journal Article] APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans2020
- Author(s)
  Yeh Tzu-Wen、Okano Tsubasa、Naruto Takuya、Yamashita Motoi、Okamura Miko、Tanita Kay、Du Likun、Pan-Hammarstrom Qiang、Mitsuiki Noriko、Okada Satoshi、Kanegane Hirokazu、Imai Kohsuke、Morio Tomohiro
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 146 Issue: 5 Pages: 1109-1120
- DOI
  10.1016/j.jaci.2020.03.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18KK0228
[Journal Article] Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome2019
- Author(s)
  Hoshino Akihiro、Kanegane Hirokazu、Nishi Masanori、Tsuge Ikuya、Tokuda Kiriko、Kobayashi Ichiro、Imai Kohsuke、Morio Tomohiro、Takagi Masatoshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 203 Pages: 9-13
- DOI
  10.1016/j.clim.2019.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17K17692
[Journal Article] Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 12019
- Author(s)
  Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 143 Issue: 1 Pages: 421-424
- DOI
  10.1016/j.jaci.2018.07.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17K17692
[Journal Article] Epstein-Barr Virus-Associated γδ T-Cell Lymphoproliferative Disorder Associated With Hypomorphic IL2RG Mutation2019
- Author(s)
  Tanita K, Hoshino A, Imadome K, Kamiya T, Inoue K, Okano T, Yeh TW, Yanagimachi M, Shiraishi A, Ishimura M, Schober T, Rohlfs M, Takagi M, Imai K, Takada H, Ohga S, Klein C, Morio T, Kanegane H.
- Journal Title
  
  Front Pediatr
  
  Volume: 7 Pages: 15-15
- DOI
  10.3389/fped.2019.00015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-19H03613, KAKENHI-PROJECT-17K17692, KAKENHI-PROJECT-19K08336
[Journal Article] Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency2019
- Author(s)
  Kumaki Eri、Tanaka Keisuke、Imai Kohsuke、Aoki-Nogami Yuki、Ishiguro Akira、Okada Satoshi、Kanegane Hirokazu、Ishikawa Fumihiko、Morio Tomohiro
- Journal Title
  
  International Journal of Hematology
  
  Volume: 109 Issue: 4 Pages: 382-389
- DOI
  10.1007/s12185-019-02614-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10099
[Journal Article] Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 12018
- Author(s)
  Tamura A, Uemura S, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Hiroki H, Okano T, Imai K, Morio T, Kanegane H, Kosaka Y.
- Journal Title
  
  Allergy Asthma Clin Immunol
  
  Volume: 14 Issue: 1 Pages: 82-82
- DOI
  10.1186/s13223-018-0306-1
- NAID
  120006818739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07814
[Journal Article] Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases2018
- Author(s)
  Okano Tsubasa、Tsujita Yuki、Kanegane Hirokazu、Mitsui-Sekinaka Kanako、Tanita Kay、Miyamoto Satoshi、Yeh Tzu-Wen、Yamashita Motoi、Terada Naomi、Ogura Yumi、Takagi Masatoshi、Imai Kohsuke、Nonoyama Shigeaki、Morio Tomohiro
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 38 Issue: 3 Pages: 300-306
- DOI
  10.1007/s10875-018-0497-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04233, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07814
[Journal Article] Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency2018
- Author(s)
  Boutboul D, Kuehn HS, Van de Wyngaert Z, Niemela JE, Callebaut I, Stoddard J, Lenoir C, Barlogis V, Farnarier C, Vely F, Yoshida N, Kojima S, Kanegane H, Hoshino A, Hauck F, Lhermitte L, Asnafi V, Roehrs P, Chen S, Verbsky JW,et al.
- Journal Title
  
  J Clin I)nvest
  
  Volume: 128 Issue: 7 Pages: 3071-3087
- DOI
  10.1172/jci98164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10099
[Journal Article] Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing2018
- Author(s)
  Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, et al.
- Journal Title
  
  Int J Hematol
  
  Volume: 108 Issue: 3 Pages: 319-328
- DOI
  10.1007/s12185-018-2475-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07814
[Journal Article] Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.2018
- Author(s)
  Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T.
- Journal Title
  
  Am J Hum Genet
  
  Volume: 102 Issue: 3 Pages: 480-486
- DOI
  10.1016/j.ajhg.2018.01.019
- NAID
  120006502505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-16H05357, KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-15K15321, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-16H03293
[Journal Article] Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency.2018
- Author(s)
  Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 141 Issue: 3 Pages: 1060-1073
- DOI
  10.1016/j.jaci.2017.05.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10099
[Journal Article] Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis2018
- Author(s)
  Yatsushiro Yuki、Nishikawa Takuro、Saito Aki、Nakazawa Yozo、Imadome Ken-Ichi、Nakagawa Shunsuke、Kodama Yuichi、Okamoto Yasuhiro、Kanegane Hirokazu、Kawano Yoshifumi
- Journal Title
  
  Journal of Pediatric Hematology and Oncology
  
  Volume: 0 Issue: 1 Pages: 1-1
- DOI
  10.1097/mph.0000000000001075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10117, KAKENHI-PROJECT-17K10099
[Journal Article] Inflammatory bowel diseases and primary immunodeficiency diseases2018
- Author(s)
  Kanegane H.
- Journal Title
  
  Immunol Med
  
  Volume: 41 Issue: 4 Pages: 154-161
- DOI
  10.1080/25785826.2018.1556025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10099
[Journal Article] Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease2018
- Author(s)
  Tanaka-Kubota M, Shinozaki K, Miyamoto S, Yanagimachi M, Okano T, Mitsuiki N, Ueki M, Yamada M, Imai K, Takagi M, Agematsu K, Kanegane H, Morio T
- Journal Title
  
  Int J Hematol
  
  Volume: 5 Issue: 5 Pages: 610-614
- DOI
  10.1007/s12185-017-2375-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07814
[Journal Article] IKBA S32 Mutations Underlie Ectodermal Dysplasia with Immunodeficiency and Severe Noninfectious Systemic Inflammation2018
- Author(s)
  Moriya K, Sasahara Y, Ohnishi H, Kawai T, Kanegane H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 38 Issue: 5 Pages: 543-545
- DOI
  10.1007/s10875-018-0522-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07840
[Journal Article] High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations.2018
- Author(s)
  Hoshino A, Tanita K, Kanda K, Imadome K, Shikama Y, Yasumi T, Imai K, Takagi M, Morio T, Kanegane H.
- Journal Title
  
  Clin Immunol
  
  Volume: 195 Pages: 45-48
- DOI
  10.1016/j.clim.2018.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-17K17692
[Journal Article] Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders.2018
- Author(s)
  Kadowaki T, Ohnishi H, Kawamoto N, Hori T, Nishimura K, Kobayashi C, Shigemura T, Ogata S, Inoue Y, Kawai T, Hiejima E, Takagi M, Imai K, Nishikomori R, Ito S, Heike T, Ohara O, Morio T, Fukao T, Kanegane H.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 141 Issue: 4 Pages: 1485-1488
- DOI
  10.1016/j.jaci.2017.10.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-18K07814
[Journal Article] Flow cytometry-based diagnosis of primary immunodeficiency diseases2018
- Author(s)
  Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T.
- Journal Title
  
  Allergol. Int.
  
  Volume: 67 Issue: 1 Pages: 43-54
- DOI
  10.1016/j.alit.2017.06.003
- NAID
  130006322088
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-15K09642, KAKENHI-PROJECT-15K09655, KAKENHI-PROJECT-16K15528
[Journal Article] Genetic heterogeneity of uncharacterized childhood autoimmune diseases with lymphoproliferation.2018
- Author(s)
  Takagi M, Hoshino A, Yoshida K, Ueno H, Imai K, Piao J, Kanegane H, Yamashita M, Okano T, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Hayashi Y, Kojima S, Morio T.
- Journal Title
  
  Pediatr Blood Cancer.
  
  Volume: 65 Issue: 2
- DOI
  10.1002/pbc.26831
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-15K09640, KAKENHI-PLANNED-15H05909
[Journal Article] Effect of reduced-intensity conditioning and the risk of late-onset non-infectious pulmonary complications in pediatric patients.2017
- Author(s)
  Nagasawa M, Mitsuiki N, Aoki Y, Ono T, Isoda T, Imai K, Takagi M, Kajiwara M, Kanegane H, Morio T.
- Journal Title
  
  Eur J Haematol
  
  Volume: 99 Issue: 6 Pages: 525-531
- DOI
  10.1111/ejh.12967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-15K09639, KAKENHI-PROJECT-15K09640
[Journal Article] Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome.2017
- Author(s)
  Takagi M, Ogata S, Ueno H, Yoshida K, Yeh T, Hoshino A, Piao J, Yamashita M, Nanya M, Okano T, Kajiwara M, Kanegane H, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Bando Y, Kato M, Hayashi Y, Miyano S, Imai K, Ogawa S, Kojima S, Morio T.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: - Issue: 6 Pages: 31286-6
- DOI
  10.1016/j.jaci.2016.09.038
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-26293244, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-17K10099, KAKENHI-PLANNED-15H05912
[Journal Article] Targeted Sequencing and Immunological Analysis Reveal the Involvement of Primary Immunodeficiency Genes in Pediatric IBD: a Japanese Multicenter Study2017
- Author(s)
  Suzuki T, Sasahara Y, Kikuchi A, Kakuta H, Kashiwabara T, Ishige T, Nakayama Y, Tanaka M, Hoshino A, Kanegane H, Abukawa D, Kure S
- Journal Title
  
  J Clin Immunol
  
  Volume: 37 Issue: 1 Pages: 67-79
- DOI
  10.1007/s10875-016-0339-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan.2017
- Author(s)
  3.Ono S, Okano T, Hoshino A, Yanagimachi M, Hamamoto K, Nakazawa Y, Imamura T, Onuma M, Niizuma H, Sasahara Y, Tsujimoto H, Wada T, Kunisaki R, Takagi M, Imai K, Morio T, Kanegane H.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 37 Issue: 1 Pages: 85-91
- DOI
  10.1007/s10875-016-0348-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293244, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-15K15386, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-15K09642
[Journal Article] Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy.2017
- Author(s)
  Okano T, Nishikawa T, Watanabe E, Watanabe T, Takashima T, Yeh TW, Yamashita M, Tanaka-Kubota M, Miyamoto S, Mitsuiki N, Takagi M, Kawano Y, Mochizuki Y, Imai K, Kanegane H, Morio T.
- Journal Title
  
  Clin Immunol.
  
  Volume: 183 Pages: 112-120
- DOI
  10.1016/j.clim.2017.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10033, KAKENHI-PROJECT-16K10034, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-15K09640
[Journal Article] Multicolor Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases.2017
- Author(s)
  Takashima T, Okamura M, Yeh TW, Okano T, Yamashita M, Tanaka K, Hoshino A, Mitsuiki N, Takagi M, Ishii E, Imai K, Kanegane H, Morio T.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 37 Issue: 5 Pages: 486-495
- DOI
  10.1007/s10875-017-0405-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-15K09640
[Journal Article] Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations.2017
- Author(s)
  Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Kobayashi M, Nakamura H, Kamizono J, Mitsui-Sekinaka K, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: - Issue: 1 Pages: 390-400
- DOI
  10.1016/j.jaci.2016.09.029
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-26293244, KAKENHI-PROJECT-26293250, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-15K15386, KAKENHI-PROJECT-15K21189, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17K10112, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-16K15528
[Journal Article] Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity2016
- Author(s)
  Ikegame K, Imai K, Yamashita M, Hoshino A, Kanegane H, Morio T, Kaida K, Inoue T, Soma T, Tamaki H, Okada M, Ogawa H
- Journal Title
  
  J Hematol Oncol
  
  Volume: 9 Issue: 1 Pages: 9-9
- DOI
  10.1186/s13045-016-0240-y
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency.2016
- Author(s)
  5.Sato T, Okano T, Tanaka-Kubota M, Kimura S, Miyamoto S, Ono S, Yamashita M, Mitsuiki N, Takagi M, Imai K, Kajiwara M, Ebato T, Ogata S, Oda H, Ohara O, Kanegane H, Morio T.
- Journal Title
  
  Pediatr Int.
  
  Volume: 58 Issue: 10 Pages: 1076-1080
- DOI
  10.1111/ped.13070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293244, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-15K09640
[Journal Article] Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency.2016
- Author(s)
  Tsujita Y, et al.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 138 Issue: 6 Pages: 1672-1680
- DOI
  10.1016/j.jaci.2016.03.055
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-15H06186, KAKENHI-PROJECT-26293244, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-15K09710, KAKENHI-PROJECT-16K15528
[Journal Article] Somatic mosaicism for a NRAS mutation associates with disparate clinical features in RAS-associated leukoproliferative disease: a report of two cases.2015
- Author(s)
  Shiota M, Yang X, Kubokawa M, Morishima T, Tanaka K, Mikami M, Yoshida K, Kikuchi M, Izawa K, Nishikomori R, Okuno Y, Wang X, Sakaguchi H, Muramatsu H, Kojima S, Miyano S, Ogawa S, Takagi M, Hata D, Kanegane H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 35 Issue: 5 Pages: 454-458
- DOI
  10.1007/s10875-015-0163-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease.2015
- Author(s)
  Hiejima E, Kawai T, Nakase H, Tsuruyama T, Morimoto T, Yasumi T, Taga T, Kanegane H, Hori M, Ohmori K, Higuchi T, Matsuura M, Yoshino T, Ikeuchi H, Kawada K, Sakai Y, Kitazume MT, Hisamatsu T, Chiba T, Nishikomori R, Heike T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 21 Issue: 7 Pages: 1529-1540
- DOI
  10.1097/mib.0000000000000397
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Dysgammaglobulinemia Associated With Glu349del, a Hypomorphic XIAP Mutation2015
- Author(s)
  Nishida N, Yang X, Takasaki I, Imai K, Kato K, Inoue Y, Imamura T, Miyashita R, Kato F, Yamaide A, Mori M, Saito S, Hara J, Adachi Y, Miyawaki T, Kanegane H.
- Journal Title
  
  J Investig Allergol Clin Immunol
  
  Volume: 25 Pages: 205-213
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism.2015
- Author(s)
  Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, Wada T, Gunji M, Toma T, Kato T, Shiraishi Y, Iwata A, Hori T, Kitoh T, Chiba K, Tanaka H, Sanada M, Takahashi Y, Nonoyama S, Ito M, Miyano S, Ogawa S, Kojima S, Kanegane H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 35 Issue: 7 Pages: 610-614
- DOI
  10.1007/s10875-015-0202-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09642, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-24590713
[Journal Article] A Female Patient with Incomplete Hemophagocytic Lymphohistiocytosis Caused by a Heterozygous XIAP Mutation Associated with Non-Random X-Chromosome Inactivation Skewed Towards the Wild-Type XIAP Allele2015
- Author(s)
  Yang X, Hoshino A, Taga T, Kunitsu T, Ikeda Y, Yasumi T, Yoshida K, Wada T, Miyake K, Kubota T, Okuno Y, Muramatsu H, Adachi Y, Miyano S, Ogawa S, Kojima S, Kanegane H
- Journal Title
  
  J Clin Immunol
  
  Volume: 35(3) Issue: 3 Pages: 244-8
- DOI
  10.1007/s10875-015-0144-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860852, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K09642, KAKENHI-PROJECT-26461570
[Journal Article] Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency2014
- Author(s)
  Wada T, Kanegane H, Ohta K, Katoh F, Imamura T, Nakazawa Y, Miyashita R, Hara J, Hamamoto K, Yang X, Filipovich AH, Marsh RA, Yachie A.
- Journal Title
  
  Cytokine
  
  Volume: 65 Issue: 1 Pages: 74-78
- DOI
  10.1016/j.cyto.2013.09.007
- NAID
  120005349175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591591, KAKENHI-PROJECT-24591542, KAKENHI-PROJECT-26461570
[Journal Article] Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report from the Japan HLH/LCH Study Group2014
- Author(s)
  Kogawa K, Sato H, Asano T, Ohga S, Kudo K, Morimoto A, Ohta S, Wakiguchi H, Kanegane H, Oda M, Ishii E
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 61 Issue: 7 Pages: 1257-62
- DOI
  10.1002/pbc.24980
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591577, KAKENHI-PROJECT-26461570
[Journal Article] XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.2014
- Author(s)
  Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ.
- Journal Title
  
  Cell Rep
  
  Volume: 7 Issue: 6 Pages: 1796-1808
- DOI
  10.1016/j.celrep.2014.05.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461570
[Journal Article] Clinical and genetic characteristics of XIAP deficiency in Japan2012
- Author(s)
  Yang X, Kanegane H, 他15名
- Journal Title
  
  J Clin Immunol
  
  Volume: 32 Pages: 411-420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry2012
- Author(s)
  Zhao M, Kanegane H, 他10名
- Journal Title
  
  Cytometry B Clin Cytom
  
  Volume: 80 Pages: 8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyeliti2012
- Author(s)
  Nakaoka H, Kanegane H, 他15名
- Journal Title
  
  Int J Hematol
  
  Volume: 24
- NAID
  10030793746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 22012
- Author(s)
  Yang X, Kanegane H, et al
- Journal Title
  
  Herpesviridae
  
  Volume: 3 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils2012
- Author(s)
  Honda F, Kanegane H, 他7名(3番目)
- Journal Title
  
  Nat Immunol
  
  Volume: 13 Pages: 36-378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Severe primary antibody deficiency due to a novel mutation of micro heavy chain2012
- Author(s)
  Mohammadzadeh I, Kanegane H, 他10名(9番目)
- Journal Title
  
  J Investig Allergol Clin Immunol
  
  Volume: 22 Pages: 78-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Characterization of Epstein-Barr virus(EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 22012
- Author(s)
  Yang X, Kanegane H, 他11名(13番目)
- Journal Title
  
  Herpesviridae
  
  Volume: 3 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils2012
- Author(s)
  Honda F, Kanegane H, et al
- Journal Title
  
  Nat Immunol
  
  Volume: 13 Issue: 4 Pages: 369-378
- DOI
  10.1038/ni.2234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-23390270, KAKENHI-PROJECT-23659518
[Journal Article] Clinical and genetic characteristics of XIAP deficiency in Japan2012
- Author(s)
  Yang X, Kanegane H, et al
- Journal Title
  
  J Clin Immunol
  
  Volume: 32(3)巻 Pages: 411-420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Clinical features and outcome of X-linked lymphoproliferative syndrome type 1(SAP deficiency) in Japan identified by the combination of flow cytometric assay and genetic analysis2012
- Author(s)
  Kanegane H, 他7名
- Journal Title
  
  Pediatr Allergy Immunol
  
  Volume: 21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry.2011
- Author(s)
  Zhao M, Kanegane H, Miyawaki T, et al.
- Journal Title
  
  Cytometry B Clin Cytom
  
  Volume: 80 Pages: 8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Disseminated BCG infection mimicking metastatic nasopharyngeal carcinoma in an immunodeficient child with a novel hypomorphic NEMO mutation2011
- Author(s)
  Imamura M, Kanegane H, et al
- Journal Title
  
  J Clin Immunol
  
  Volume: 31 Pages: 802-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] 幼児期に見逃されてしまったX連鎖無ガンマグロブリン血症の1例2011
- Author(s)
  竹綱庸仁、金兼弘和、他8名(10番目)
- Journal Title
  
  小児科臨床
  
  Volume: 64 Pages: 64-65
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a familyhaploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011
- Author(s)
  Ohta H, Kanegane H, 他12名(12番目)
- Journal Title
  
  Int J Hematol
  
  Volume: 94 Pages: 285-290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP-deficiency) versus type 2 (XLP-2/XIAP-deficiency)2011
- Author(s)
  Pachlopnik Schmid J, Kanegane H, et al
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 1522-1529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection2011
- Author(s)
  Nomura K, Kanegane H, 他5名
- Journal Title
  
  Int J Hematol
  
  Volume: 93 Pages: 760-764
- NAID
  10029535559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency : a multicenter study on the manifestations, management, and outcome of the disease.2011
- Author(s)
  Booth C, Kanegane H, et al.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 53-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency : a multicenter study on the manifestations, management, and outcome of the disease2011
- Author(s)
  Booth C, Kanegane H, 他46名(39番目)
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 53-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Atypical case of X-linked agammaglobulinemia diagnosed at 45 years of age2011
- Author(s)
  Fujioka T, Kanegane H, 他6名(7番目)
- Journal Title
  
  Pediatr Int
  
  Volume: 53 Pages: 611-612
- NAID
  10029559433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis2011
- Author(s)
  Kawakami C, Kanegane H, 他4名(4番目)
- Journal Title
  
  Acta Paediatr
  
  Volume: 100 Pages: 466-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry2011
- Author(s)
  Zhao M, Kanegane H, et al
- Journal Title
  
  Cytometry B Clin Cytom
  
  Volume: 80 Issue: 1 Pages: 8-13
- DOI
  10.1002/cyto.b.20552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1(XLP-1/SAP-deficiency) versus type 2(XLP-2/XIAP-deficiency)2011
- Author(s)
  Pachlopnik Schmid J, Kanegane H, 他31名(7番目)
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 1522-1529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis.2011
- Author(s)
  Kawakami C, Inoue A, Kanegane H, Miyawaki T, et al.
- Journal Title
  
  Acta Paediatr
  
  Volume: 100 Pages: 466-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of earl B-cell maturation defects.2011
- Author(s)
  Nakagawa N, Kanegane H, Miyawaki T, et al.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 202(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1(XLP-1/SAP-deficiency)versus type 2(XLP-2/XIAP-deficiencv).2011
- Author(s)
  Pachlopnik Schmid J, Kanegane H, et al.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 1522-1529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Exonic deletion of CASP10 in a patient presenting with systemic juvenile idiopathic arthritis, but not with autoimmune lymphoproliferative syndrome type IIa2011
- Author(s)
  Tadaki H, Kanegane H, 他14名(3番目)
- Journal Title
  
  Int J Immunogenet
  
  Volume: 37 Pages: 287-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry.2011
- Author(s)
  Zhao M, Kanegane H, et al.
- Journal Title
  
  Cytometry B Clin Cytom
  
  Volume: 80 Pages: 8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011
- Author(s)
  Ohta H, Kanegane H, et al
- Journal Title
  
  Int J Hematol
  
  Volume: 94 Pages: 286-290
- NAID
  10029694397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan2011
- Author(s)
  Ishimura M, Kanegane H, 他13名(6番目)
- Journal Title
  
  J Clin Immunol
  
  Volume: 31 Pages: 968-976
- NAID
  120005133089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Disseminated BCG Infection Mimicking Metastatic Nasopharyngeal Carcinoma in an Immunodeficient Child with a Novel Hypomorphic NEMO Mutation2011
- Author(s)
  Imamura M, Kanegane H, 他13名(7番目)
- Journal Title
  
  J Clin Immunol
  
  Volume: 31 Pages: 802-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis.2011
- Author(s)
  Kawakami C, Kanegane H, et al.
- Journal Title
  
  Acta Paediatr
  
  Volume: 100 Pages: 466-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection2011
- Author(s)
  Nomura K, Kanegane H, et al
- Journal Title
  
  Int J Hematol
  
  Volume: 93 Pages: 760-4
- NAID
  10029535559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] 幼児期に見逃されてしまったX連鎖無ガンマグロブリン血症の1例2011
- Author(s)
  竹綱庸仁、金兼弘和, ほか
- Journal Title
  
  小児科臨床
  
  Volume: 64 Pages: 61-65
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Identification of FOXP3-negative regulatory T-like (CD4^+CD25^+CD127^<low>) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2011
- Author(s)
  Otsubo K, Kanegane H, et al
- Journal Title
  
  Clin Immunol
  
  Volume: 141 Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Quantification ofκ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects2011
- Author(s)
  Nakagawa N, Kanegane H, 他22名(3番目)
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis.2011
- Author(s)
  Kawakami C, Inoue A, Takitani K, Kanegane H., Miyawaki T., Tamai H.
- Journal Title
  
  Acta Paediatr 100巻
  
  Pages: 466-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes2011
- Author(s)
  Arai T, Kanegane H, 他8名(3番目)
- Journal Title
  
  J Hum Genet
  
  Volume: 56 Pages: 577-582
- NAID
  10030660427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Quantification of K-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects2011
- Author(s)
  Nakagawa N, Kanegane H, et al
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 128 Pages: 223-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Identification of FOXP3-negative regulatory T-like(CD4^+CD25^+CD127^<low>) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2011
- Author(s)
  Otsubo K, Kanegane H, 他15名、
- Journal Title
  
  Clin Immunol
  
  Volume: 141 Pages: 111-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly.2010
- Author(s)
  Zhao M., Kanegane H., Ouchi K., Imamura T., latour S., Miyawaki T.
- Journal Title
  
  Haematologica 95巻
  
  Pages: 688-689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] IPEX症候群とヒトTreg細胞2010
- Author(s)
  大坪慶輔、金兼弘和, ほか
- Journal Title
  
  臨床免疫学会雑誌
  
  Volume: 33 Pages: 196-206
- NAID
  130006949797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Hyper IgD and periodic fever syndrome in Japan.2010
- Author(s)
  Kawashima Kanegane H, et al.
- Journal Title
  
  J Tokyo Med Univ
  
  Volume: 68 Pages: 235-238
- NAID
  10026237739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly.2010
- Author(s)
  Zhao M, Kanegane H, Miyawaki T, et al.
- Journal Title
  
  Haematologica
  
  Volume: 95 Pages: 688-689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly.2010
- Author(s)
  Zhao M, Kanegane H, et al.
- Journal Title
  
  Haematogica
  
  Volume: 95 Pages: 688-689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] ETV6-ARNT fusion in a patient with childhood T lymphoblastic leukemia.2010
- Author(s)
  Otsubo K, Kanegane H, Ishii E, Miyawaki T., et al.
- Journal Title
  
  Cancer Genet Cytogenet.
  
  Volume: 202 Pages: 22-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Case of acute cerebellar ataxia associated with primary Epstein-Barr virus infection.2010
- Author(s)
  Harai T, Kanegane H, Ito Y., Miyawaki T., et al.
- Journal Title
  
  Pediatr Int.
  
  Volume: 52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Noncompaction study collaborators.Gonadal mosaicism of a TAZ (G4.5) mutation in a Japanese family with Barth syndrome and left ventricular noncompaction.2010
- Author(s)
  Chang B, Kanegane H, Ichida F, Miyawaki T, et al.
- Journal Title
  
  Mol Genet Metab
  
  Volume: 100 Pages: 198-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells.2009
- Author(s)
  Shira MM, Kanegane H, et al.
- Journal Title
  
  Int Immunol 21
  
  Pages: 1013-1023
- NAID
  10027389170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal guthrie cards.2009
- Author(s)
  Morinishi Y., Kanegane H., Miyawaki T., et al
- Journal Title
  
  J Pediatr 155巻
  
  Pages: 829-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Mutation of the BTK gene and clinical feature of X-linked agammaglob ulinemia in Mainland China.2009
- Author(s)
  Wang Y, Kanegane H, et al.
- Journal Title
  
  J Clin Immunol 29
  
  Pages: 352-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal guthrie cards.2009
- Author(s)
  Morinishi Y., Kanegane H., Miyawaki T., et al
- Journal Title
  
  J Pediatr 155
  
  Pages: 829-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Early lineage switch in an infant acute lymphoblastic leukemia.2009
- Author(s)
  Sakaki H., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Int J Hematol 90
  
  Pages: 653-655
- NAID
  10026110210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Chemokine receptor expression and functional effects of chemokines on B cells : implication in the pathogenesis of rheumatoid arthritis.2009
- Author(s)
  Nanki T, Kanegane H, et al.
- Journal Title
  
  Arthritis Res Ther 11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Mutation of the BTK Gene and clinical feature of X-linked agammaglobulinemia in Mainland China.2009
- Author(s)
  Wang Y., Kanegane H., Miyawaki T., et al
- Journal Title
  
  J Clin Immunol 29巻
  
  Pages: 352-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] IPEX症候群と腎疾患2009
- Author(s)
  橋村裕也、金兼弘和, ほか
- Journal Title
  
  日本小児腎臓病学会雑誌 22
  
  Pages: 131-139
- NAID
  10026411780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Three brothers of X-linked agammaglobulinemia : the relation between phenotype and neutropenia.2009
- Author(s)
  Kawakami C, Kanegane H, et al.
- Journal Title
  
  Int J Hematol 90
  
  Pages: 117-119
- NAID
  10025162704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.2009
- Author(s)
  Hashimura Y, Nozu K, Kanegane H, Miyawaki T., et al.
- Journal Title
  
  Pediatr Nephrol 24巻
  
  Pages: 1181-1186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Pneumocytis jiroveci pneumonia as a an atypical presentation of X-linked agammaglobulinemia.2009
- Author(s)
  Kanegane H., Miyawaki T., et al.
- Journal Title
  
  Int J Hematol 89
  
  Pages: 716-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] IPEX症候群と腎疾患2009
- Author(s)
  橋村裕也, 金兼弘和, 宮脇利男, 他
- Journal Title
  
  日本小児腎臓学会誌 22
  
  Pages: 131-135
- NAID
  10026411780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Pneumocytis jiroveci pneumonia as an atypical presentation of X-linked agammaglobulinemia.2009
- Author(s)
  Kanegane H., Nakano T., Shimono Y., Zhao M., Miyawaki T.
- Journal Title
  
  Int J Hematol 89巻
  
  Pages: 716-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] 新生児における免疫機能とその発達2009
- Author(s)
  金兼弘和
- Journal Title
  
  日本産婦人科・新生児血液学会誌 18
  
  Pages: 155-164
- NAID
  10026710069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Epstein-Barrウイルス関連血球貪食性リンパ組織球症2例における免疫学的・ウイルス学的解析2009
- Author(s)
  田村賢太郎, 金兼弘和, 宮脇利男, 他
- Journal Title
  
  日本小児血液学会雑誌 23
  
  Pages: 360-365
- NAID
  10029311258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Pneumocystis jiroveci pneumonia as an atypical presentation of X-linked agammaglobulinemia.2009
- Author(s)
  Kanegane H, et al.
- Journal Title
  
  Int J Hematol 89
  
  Pages: 716-717
- NAID
  10025162231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Neutropenia associated with x-linked agammaglobulinemia in an Iranian referral center.2009
- Author(s)
  Aghamohammadi A., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Iran J Allergy Asthma Immunol 8
  
  Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal Guthrie cards2009
- Author(s)
  Morinishi Y, Kanegane H, et al.
- Journal Title
  
  J Pediatr 155
  
  Pages: 829-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Mutation of the BTK Gene and clinical feature of X-linked a gammaglobulinemia in Mainland China.2009
- Author(s)
  Wang Y., Kanegane H., Miyawaki T, et al
- Journal Title
  
  J Clin Immunol 29
  
  Pages: 352-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Three brothers of X-kinked agammaglobulinemia ; the relation between phenotype and neutropenia.2009
- Author(s)
  Kawakami C., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Int J Hematol 90
  
  Pages: 117-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Neutropenia associated with X-linked agammaglobulinemia in an Iranian referral center.2009
- Author(s)
  Aghamohammadi A, Kanegane H, et al.
- Journal Title
  
  Iran J Allergy Asthma Immunol 8
  
  Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Minimal change nephritic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.2009
- Author(s)
  Hashimura Y, Kanegane H, et al
- Journal Title
  
  Pediatr Nephrol 24
  
  Pages: 1181-1186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591350
[Journal Article] Neutropenia associated with x-linked agammaglobulinemia in an Iranian referral center.2009
- Author(s)
  Aghamohammadi A., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Iran J Allergy Asthma Immunol 8巻
  
  Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Functional analysis of JAK3 mutation in transient myeloprolife rative disoder and acute megakaryoblastic leukaemia accompanying Down syndrome2008
- Author(s)
  Sato T., Kanegane H., et al
- Journal Title
  
  Brit J Haematol 141
  
  Pages: 681-688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen2008
- Author(s)
  Tsurusawa M., Kanegane H., et al
- Journal Title
  
  Leuk Lymphoma 49
  
  Pages: 734-739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Atypical lymphoproliferative disorder in a patient with X-linked thrombocytopenia.2008
- Author(s)
  Otubo K., Kanegane H., Nomura K., Miyawaki T.
- Journal Title
  
  Pediatr Bllod Cancer 51巻
  
  Pages: 443-444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia2008
- Author(s)
  Taneichi H., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Clin Immuno 126
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] A CIAS1 mutation in a Japanese girl with familial cold autoinflammatory syndrome2008
- Author(s)
  Kanegane, H., et. al.
- Journal Title
  
  Eur J Pediatr 167
  
  Pages: 245-247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591185
[Journal Article] Atypical lymphoproliferative disorder in a patient with X-linked thrombocytopenia2008
- Author(s)
  Otubo K., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Pediatr Bllod Cancer 51
  
  Pages: 443-444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia.2008
- Author(s)
  Taneichi H., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Clin Immunol 126巻
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Hemophagocytis lymphohistiocytosis associated with uncontrolled inflammatory cytokinemia and chemokinemia was caused by systemic anaplastic large cell lyiphoma2008
- Author(s)
  Shimada A., Kanegane H., et al
- Journal Title
  
  J Pediatr Hematol Oncol 30
  
  Pages: 785-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] A CIASI mutation in a Japanese girl with familial cold autoinflammatory syndrome2008
- Author(s)
  Kanegane H., Miyawaki T., et al
- Journal Title
  
  Eur J Pediatr 167
  
  Pages: 245-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] A CIAS1 mutation in a Japanese girl with familial cold autoinflammatory syndrome.2008
- Author(s)
  Kanegane H., Adachi Y., Miyawaki T., et al
- Journal Title
  
  Eur J Pediatr 167巻
  
  Pages: 245-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Molecular characterization of two novel VEGFR3 mutations in Japanese families with Milroy's disease2008
- Author(s)
  Futatani T., Kanegane H., Miyawaki T., et al
- Journal Title
  
  Pediatr Int 50
  
  Pages: 116-118
- NAID
  10024152911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Journal Article] Novel mutations in a Japanese patient with CD 19 deficiency2007
- Author(s)
  Kanegane, H., et. al.
- Journal Title
  
  Genes Immun 8
  
  Pages: 663-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591185
[Journal Article] Novel mutations in a Japanese patient with CD19 deficiency2007
- Author(s)
  Kanegane H, et. al.
- Journal Title
  
  Genes and Immunity 8
  
  Pages: 663-670
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591185
[Journal Article] X-linked lymphoproliferative syndrome presenting with systemic lymphocytic vasculitis2005
- Author(s)
  Kanegane H, Ito Y, Ohshima K, et al.
- Journal Title
  
  American Journal of Hematology 78
  
  Pages: 130-133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591095
[Journal Article] わが国におけるX連鎖無γグロブリン血症の臨床診断に関する検討2004
- Author(s)
  種市尋宙, 金兼弘和, 二谷武, 他
- Journal Title
  
  日本小児科学会雑誌 108
  
  Pages: 1118-1122
- NAID
  10017041259
- Data Source
  KAKENHI-PROJECT-15591095
[Journal Article] Female agammaglobulinemia due to the Bruton tyrosine kinase deficiency caused by extremely skewed X-chromosome in activation2004
- Author(s)
  Takada H, Kanegane H, Nomura A, et al.
- Journal Title
  
  Blood 103
  
  Pages: 185-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591095
[Journal Article] Female agammaglobulinemia due to the Bruton tyrosine kinase deficiency caused by extremely skewed X-chromosome inactivation2004
- Author(s)
  Takada H, Kanegane H, Nomura A, et al.
- Journal Title
  
  Blood 103
  
  Pages: 185-187
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591095
[Journal Article] Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects.
- Author(s)
  Nakagawa N, Imai K, Kanegane H., Miyawaki T., Nonoyama S., et al
- Journal Title
  
  J Allergy Clin Immunol 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] ALPS & ALPS-like and IPEX & IPEX-like2022
- Author(s)
  Hirokazu Kanegane
- Organizer
  4th Asia-Pacific Society for Immunodeficiencies Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] An Approach to Antibody Deficiencies2022
- Author(s)
  Hirokazu Kanegane
- Organizer
  4th Asia-Pacific Society for Immunodeficiencies Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] A B-Cell Deficient Japanese Girl with ZIP7 Deficiency Caused by Novel Compound Heterozygous Variants in SLC39A72022
- Author(s)
  Hirokazu Kanegane
- Organizer
  13th International Congress of Immunodeficiency Diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] Hematopoietic stem cell transplantation for PID2022
- Author(s)
  Hirokazu Kanegane
- Organizer
  17th Congress of Asian Society for Pediatric Research (ASPR 2022)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] 原発性免疫不全症の最新知見2022
- Author(s)
  金兼弘和
- Organizer
  第54回日本小児感染症学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] The future of BMT in Asia2022
- Author(s)
  Hirokazu Kanegane
- Organizer
  IPOPI 4th Regional Asian PID Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] Finding NEMO2022
- Author(s)
  Hirokazu Kanegane
- Organizer
  The 1st National IEI Congress of China 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07887
[Presentation] Selective dysregulation of Epstein Barr virus infection in hypomorphic ZAP70 mutation2016
- Author(s)
  26.Kanegane H, Hoshino A, Takashima T, Yeh T-W, Okano T, Yamashita M, Imai K, Morio T
- Organizer
  XLP-WAS 2016 Symposium
- Place of Presentation
  London （United Kingdom）
- Year and Date
  2016-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 10 warning signsから知る原発性免疫不全症2016
- Author(s)
  金兼弘和
- Organizer
  沖縄小児科学会　第85回例会
- Place of Presentation
  沖縄県医師会館（南風原市、沖縄県）
- Year and Date
  2016-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Recent advances in primary antibody immunodeficiency and immunoglobulin replacement therapy2016
- Author(s)
  Kanegane H
- Organizer
  21th Congress of Chinese Pediatric Society
- Place of Presentation
  Zhuhai (Main China)
- Year and Date
  2016-10-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Use of flow cytometry in PID diagnosis2016
- Author(s)
  Kanegane H
- Organizer
  APSID Main Congress
- Place of Presentation
  Hong Kong （Main China)
- Year and Date
  2016-04-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 原発性免疫不全症と血液学2016
- Author(s)
  金兼弘和
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜市 (日本)
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Immunoglobulin replacement for agammaglobulinemia - intravenous or subcutanesou?2016
- Author(s)
  Kanegane H
- Organizer
  APSID Main Congress
- Place of Presentation
  Hong Kong (Main China)
- Year and Date
  2016-04-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] XLP (X-linked lympho proliferative syndrome) and Epstein-Barr virus infection2015
- Author(s)
  Kanegane H
- Organizer
  V Simpósio Internacional de Immunodeficiências Primárias—SIDEP
- Place of Presentation
  Belo Horizonte, Brazil
- Year and Date
  2015-05-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Reemerging subcutaneous immunoglobulin replacement therapy for primary antibody deficiency.2015
- Author(s)
  Kanegane H
- Organizer
  ASPR Meeting
- Place of Presentation
  大坂国際会議場（大阪市、大阪府）
- Year and Date
  2015-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 免疫不全症と感染症 overview2015
- Author(s)
  金兼弘和
- Organizer
  第64回日本感染症学会東日本地方会学術集会
- Place of Presentation
  ロイトン札幌（札幌市、北海道）
- Year and Date
  2015-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 免疫不全時の感染症2015
- Author(s)
  金兼弘和
- Organizer
  第47回日本小児感染症学会
- Place of Presentation
  ザ・セレクトン福島（福島市、福島県）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 原発性免疫不全症における臨床遺伝学「抗体産生不全症における臨床遺伝学」2011
- Author(s)
  金兼弘和
- Organizer
  遺伝医学合同学術集会2011
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] 抗体産生不全症における臨床遺伝学2011
- Author(s)
  金兼弘和
- Organizer
  遺伝医学合同学術集会2011
- Place of Presentation
  京都市(招待講演)
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis2011
- Author(s)
  Kanegane H
- Organizer
  The 3^<rd> Symposium for PID in Asia
- Place of Presentation
  Denver、Colorado、USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] 教育講演「腸管出血性大腸菌O111の集団発生から学んだこと」2011
- Author(s)
  金兼弘和
- Organizer
  第43回日本小児感染症学会
- Place of Presentation
  岡山市.
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis2011
- Author(s)
  Kanegane H
- Organizer
  The 3^<rd> Symposium for PID in Asia
- Place of Presentation
  Denver, Colorado, USA(招待講演)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] Identification of FOXP3-negative regulatory T-like(CD127^<dim>CD25^+CD4^+)cells in patients with IPEX.2010
- Author(s)
  Kanegane H, et al.
- Organizer
  XIVth Meeting of the European Society for Immunodeficiencies(ESID)
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] Identification of FOXP3-negative regulatory T-like (CD^<127dim>CD25^+CD4^+) cells in patients with IPEX.2010
- Author(s)
  Kanegane H., Otsubo K., Miyawaki T, et al.
- Organizer
  14^<th> Meeting of the European Society for Immunodeficiencies
- Place of Presentation
  Turkey
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] T-B+NK+ severe combined immunodeficiency caused by a common gamma chain deficiency.2010
- Author(s)
  Kanegane H., Koura U., Sakaki H., Otsubo K., Nomura K., Morio T., Wada T., Yachie A., Oshima K., Ohara O., Miyawaki T.
- Organizer
  2010 First American Primary Immune Deficiency National Conference
- Place of Presentation
  Philadelphia, USA.
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Rapid elucidation of autoimmunemediated inflammatory disease regulatory mechanisms and depiction of signaling pathway in primary immunodeficienc diseases.2010
- Author(s)
  Ramadoss S.K., Imai K., Nonoyama S., Kanegane H., Miyawaki T., et al.
- Organizer
  14^<th> Meeting of the European Society for Immunodeficiencies
- Place of Presentation
  Turkey
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Flow cytometric diagnosis of XLP1 and 22010
- Author(s)
  Kanegane H
- Organizer
  XLP symposium 2010
- Place of Presentation
  London
- Year and Date
  2010-02-15
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] Identification of FOXP3-negative regulatory T-like (CD^<127dim> CD25^+CD4^+) cells in patients with IPEX.2010
- Author(s)
  Kanegane H., Otsubo K., Yang X., Kamachi Y., Kobayashi I., Miyawaki T.
- Organizer
  14^<th> Meeting of the European Society for Immunodeficiencies
- Place of Presentation
  Turkey.
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Nation-wide survey of patients with primary.immunodeficiency diseases in Japan : 2008-The clinical characteristics of X-linked agammaglobulinemia and common variable immunodeficiency.2010
- Author(s)
  Takada H., Kanegane H., Miyawaki T, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, JAPAN
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] T-B-NK+ Severe combined immunodeficiency caused by a common gamma chain deficiency.2010
- Author(s)
  Kanegane H, et al.
- Organizer
  First CIS North American Primary Immune Deficiency National Conference
- Place of Presentation
  Philadelphia, U.S.A.
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] t(1;12)(q21;p13)を伴ったT細胞性急性リンパ性白血病におけるキメラ遺伝子解析.2009
- Author(s)
  大坪慶輔, 金兼弘和, 宮脇利男, 他
- Organizer
  第41回日本小児感染症学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] ニューモシスチス肺炎を合併したX連鎖無ガンマグロブリン血症の一例2009
- Author(s)
  金兼弘和, 宮脇利男, 他
- Organizer
  第41回日本小児感染症学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Immunological and viological analysis of EB virus-associated hemophagocytic lymphohistiocytosis.2009
- Author(s)
  Nomura K., Kanegane H., Miyawaki T., et al
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] X連鎖無ガンマグロブリン血症に合併した持続性低補体血症性腎炎2009
- Author(s)
  倉本崇, 金兼弘和, 宮脇利男, 他
- Organizer
  第112回日本小児科学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] IPEX症候群とヒトTreg細胞2009
- Author(s)
  金兼弘和
- Organizer
  第37回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21591350
[Presentation] Clinical and immunological characteristics of CD19 deficiency.2009
- Author(s)
  Kanegane H., Miyawaki T, et al
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] 網膜芽腫, 急性白血病併発患児に対する化学療法中に発症したアルジア感染症の1例2008
- Author(s)
  大坪慶輔, 金兼弘和, 宮脇利男, 他
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Severe combined immunodeficiency patients can be identified by quantification of T-cell receptor excision circles using neonatal Guthrie cards.2008
- Author(s)
  Imai K., Kanegane H., Miyawaki T., et al
- Organizer
  The 13th meeting of the European Society for Immunodeficiencies
- Place of Presentation
  Netherlands
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] 自己免疫疾患の遺伝子異常2008
- Author(s)
  金兼弘和
- Organizer
  第111回日本小児科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] 頭蓋内腫瘤性病変, 血球貪食症候群を合併し, 非血縁者間骨髄移植を施行したX連鎖リンパ増殖症候群の1例2008
- Author(s)
  梶原仲介, 金兼弘和, 他
- Organizer
  第50回日本小児血液学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] X-linked lymphoproliferative syndrome presenting as multiple lymphoid granulomatosis in the brain2008
- Author(s)
  Gocho Y., Kanegane H., et al
- Organizer
  The 4th congress of asian society for pedia trie research
- Place of Presentation
  Hawaii
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Flow cytometric diagnosis of primary immunodeficiency diseases2008
- Author(s)
  Kanegane H.
- Organizer
  Symposium for PID in Asia
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] Infection and primary antibody deficiency2008
- Author(s)
  Kanegane, H
- Organizer
  The 110th annual meeting of Japan Pediatric Society
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591185
[Presentation] Establishment of diagnostic center for PID in Japan2008
- Author(s)
  Nonoyama S., Kanegane H., Miyawaki T., et al
- Organizer
  The 13th meeting of the European Society for Immunodeficiencies
- Place of Presentation
  Netherlands
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] EBウイルス関連血球貪食性リンパ組織球症の2例2008
- Author(s)
  田村賢太郎, 金兼弘和, 宮脇利男, 他
- Organizer
  第50回日本小児血液学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-20390294
[Presentation] ワークショップ「感染と抗体産生不全」2007
- Author(s)
  金兼弘和
- Organizer
  第110回日本小児科学会
- Place of Presentation
  京都市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591185
[Presentation] X-linked dysgammaglobulinemia associated with somatically reverted memory T cells in a family with X-linked lymphoproliferative syndrome type 1
- Author(s)
  Yang X, Nishida N, Hoshino A, Goi K, Kanzaki T, Yoshida K, Muramatsu H, Ogawa S, Kojima S, Kanegane H
- Organizer
  16th Biennial Meeting of the European Society of Immunodeficiencies
- Place of Presentation
  Prague, Czech
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 原発性免疫不全症に合併する自己炎症
- Author(s)
  金兼弘和
- Organizer
  第117回日本小児科学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2014-04-11 – 2014-04-13
- Invited
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Inflammatory bowel disease in Japanese patients with XIAP deficiency
- Author(s)
  Nishida N, Yang X, Hoshino A, Kanegane H
- Organizer
  16th Biennial Meeting of the European Society of Immunodeficiencies
- Place of Presentation
  Prague, Czech
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Whole exome sequencing reveals atypical phenotype of X-linked lymphoproliferative syndrome.
- Author(s)
  Kanegane H
- Organizer
  A symposium for researchers and clinicians on XLP and WAS
- Place of Presentation
  London, U.K.
- Year and Date
  2014-11-03 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Female patient with X-linked lymphoproliferative syndrome type 2 caused by extremely skewed inactivation of X-chromosome
- Author(s)
  Yang X, Kunitsu T, Ikeda Y, Taga T, Wada T, Yachie A, Yasumi T, Heike T, Kanegane H
- Organizer
  PAS/ASPR Joint Meeting
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-05-03 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] 女児例を含むXIAP欠損症の同胞例
- Author(s)
  國津智彬, 池田勇八, 多賀　崇, 野村明孝, 竹内義博, 松井　潤, 吉田　忍, 八角高裕, 楊　曦, 金兼弘和
- Organizer
  第117回日本小児科学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] NRAS体細胞モザイク変異による自己免疫性リンパ増殖症候群様疾患の１例
- Author(s)
  楊　曦, 高木正稔, 菊池雅子, 横田俊平, 小池健一, 村松秀城, 小島勢二, 金兼弘和
- Organizer
  第117回日本小児科学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] Characterization of crohn disease in X-linked inhibitor of apoptosis protein-deficient male patients and female symptomatic carriers
- Author(s)
  Aguilar C, Lenoir C, Lambert N, Begue B, Brousse N, Canioni D, Berrebi D, Roy M, Gerart S, Chapel H, Schwerd T, Siproudhis L, Schappi M, Al-Ahmari A, Yamaide A, Mori M, Galicier L, Neven B, Routes J, Ulhig H, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Cerf Bensussan N, Ruemmele F, Hugot J.P, Latour S
- Organizer
  16th Biennial Meeting of the European Society of Immunodeficiencies
- Place of Presentation
  Prague, Czech
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] XLP (X-Linked Lymphoproliferative Syndrome) and EB-Virus infection
- Author(s)
  Kanegane H
- Organizer
  PAS/ASPR Joint Meeting
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-05-03 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PROJECT-26461570
[Presentation] XIAP欠損症における血清IL-18の持続高値
- Author(s)
  和田泰三, 金兼弘和, 太田和秀, 谷内江昭宏
- Organizer
  第117回日本小児科学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461570
[]

1. OHARA Osamu (20370926)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. MIYAWAKI Toshio (10143885)

# of Collaborated Projects: 3 results

# of Collaborated Products: 44 results
3. OKADA SATOSHI (80457241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. ADACHI Yuhichi (80184191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ISHIKAWA Fumihiko (30403918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUJIWARA Shigeyoshi (30173488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IMADOME Ken-ichi (70392488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUDA Go (60392130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUTATANI Takeshi (90272921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 廣野恵一 (80456384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川島祐介 (30588124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 津村弥来 (80646274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 浅野孝基 (50835501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 坂田園子 (50897907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HOSHINO Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. IMAI Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. NANYA Yasuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. OKAMOTO Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. KAWANO Yoshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. WADA Taizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. AKAGI Tadayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MIYAKE Kunio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 野々山恵章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 森尾友宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 大西秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 加藤善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 江藤正俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 保科隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 楠原浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 西川拓朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 服部圭一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 磯田健志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 太田和秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 大賀正一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kanegane Hirokazu 金兼 弘和

金兼 弘和 カネガネ ヒロカズ

KANEGANE Hirokazu 金兼 弘和

KANEGANE Hirokzu 金兼 弘和

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenesis common to neutropenia and B-cell deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Long-read sequencing analysis for difficult to diagnose cases of primary immunodeficiency

Principal Investigator

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Review Section

Research Institution

Multi-OMICS approaches to investigate molecular pathogenesis of primary immune deficiency

Principal Investigator

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Review Section

Research Institution

Analysis of microbiota and molecular pathogenesis in primary immunodeficiency diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Establishment of novel diagnosis and analysis of pathogenesis of herediatry lymphoproliferative disordersPrincipal Investigator

Principal Investigator

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Research Institution

Reproduction of virus-specific immunodeficiency in humanized mice

Principal Investigator

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Research Institution

Study of innate immunity in primary antibody deficiencyPrincipal Investigator

Principal Investigator

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Research Institution

Functional maturation of regulatory T cells during child growth and their disorders

Principal Investigator

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Research Institution

Establishment of diagnostic system and study of epidemiology of primary immunodeficiency diseases in East AsiaPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Studies of B cell development defects inpatients with a gamma globulinemiaPrincipal Investigator

Principal Investigator

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Research Institution

Study on rapid diagnosis of primary immunodeficiency diseases and their abnormalities in immunologic development

Principal Investigator

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Research Institution

SAP gene mutations in Epstein-Barr virus-associated illnesses and study for its pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

慢性活動性EBウイルス感染症におけるEBウイルス関連遺伝子の発現Principal Investigator

Kanegane Hirokazu 金兼弘和

金兼弘和カネガネヒロカズ

KANEGANE Hirokazu 金兼弘和

KANEGANE Hirokzu 金兼弘和