INOGUCHI Toyoshi 井口登與志

Researcher Number	00294926
Affiliation (based on the past Project Information) *help	2003 – 2006: 九州大学, 大学病院, 講師 2004: Kyushu University, University hospital, Assistant Professor, 病院・講師 2004: KYUSHU UNIVERSITY, Graduate School of Medical Sciences, Assistant Professor, 大学院・医学研究院, 講師 2002 – 2003: 九州大学, 医学研究院, 講師 2002: Kyushu University Hospital Assistant Professor(Lecturer), 医学部附属病院, 講師 2000 – 2001: 九州大学, 医学部・附属病院, 講師 1999: 九州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics Except Principal Investigator Gastroenterology / Metabolomics / 応用薬理学・医療系薬学 / Gastroenterology
Keywords	Principal Investigator Diabetes / 血管合併症 / プロテインキナーゼC / 糖尿病 / renin-angiotensin / protein kinase C / H oxidase / NAD / oxidative stress / pancreatic beta cell … More / vascular complications / NAD(P)Hオキシターゼ / レニンアンギオテンシン系 / 糖毒性 / レニンンアンジオテンシン / レニンアンジオテンシン / NAD(P)Hオキシダーゼ / 酸化ストレス / 膵β細胞 / Impaired conduction / Protein kinase C / Connexin / Gap junction / Vascular complication / 心筋 / 平滑筋細胞 / 内皮細胞 / 興奮伝導 / 脂肪酸 / インスリン抵抗性 / 伝導傷害 / コネクシン / ギャップ接合 / 合併症 … More Except Principal Investigator NASH / ROS / AMPK / NAFLD / PTEN / 糖尿病 / 活性酸素 / インスリン / 脂肪酸代謝 / 脂肪肝 / Insulin / Oxidation / Fatty acid metabolism / Fatty liver / SREBP1 / 脂肪酸酸化 / 脂肪酸合成 / 酸化 / insulin sensitivity in each organ / bio-artificial pancreas / Cowden's disease / tumor suppressor gene / phosoholipid dehydrogenase / insulin signaling / Diabetes Mellitus / 人工膵臓 / 臓器別インスリン感受性 / 人口膵臓 / Cowden病 / 癌抑制遺伝子 / リン脂質脱リン酸化酵素 / インスリンシグナル伝達 / nitroxyl radical / obese / diabetes / electron spin resonance / free radical / reactive oxygen species / トランスジェニックマウス / 心不全 / 無侵襲解析 / 循環器疾患 / スピンプローブ / 生体計測ESR / ニトロキシルラジカル / 肥満 / 電子スピン共鳴 / フリーラジカル / hepatic stellate cells / animal model / oleic acid / linoreic acid / fatty acids / glucose / fatty liver / 過酸化脂質 / 脂肪酸 / ADRP / 遺伝子治療 / リノール酸 / オレイン酸 / 肝障害 / 糖代謝 Less

Evaluation of fatty acid metabolism-related gene expression in non-alcoholic fatty liver disease
- Principal Investigator
  
  NAKAMUTA Makoto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu Medical Center, National Hospital Organization
  Kyushu University
New therapeutic strategy for diabetic complications targeting NAD(P)H oxidase activation mechanismPrincipal Investigator
- Principal Investigator
  
  INOGUCHI Toyoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseases
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
The role of phospholipid phsophatase in insulin signaling system
- Principal Investigator
  
  NAKASHIMA Naoki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Nobel Strategy of Treatment for Non-alcoholic Steatohepatits
- Principal Investigator
  
  KOTOH Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Abnormality of protein kinase C activity and gap junction activity in diabetic vascular tissuesPrincipal Investigator
- Principal Investigator
  
  INOGUCHI Toyoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University

All 2006 2005 2004 2003

All Journal Article Book

[Book] 医学のあゆみ、別冊酸化ストレス(ver.2)-フリーラジカル医学生物学の最前線、糖尿病における酸化ストレス亢進とその機序-血管壁NAD(P)Hオキシダーゼとミトコンドリアの役割.349-3512006
- Author(s)
  井口登與志
- Total Pages
  450
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] 糖尿病性腎症の成因と心血管障害への関与とその対策-酸化ストレスとPKC2006
- Author(s)
  井口登與志
- Journal Title
  
  動脈硬化予防 5(3)
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] 糖尿病性腎症治療の新しい展望-抗酸化薬2006
- Author(s)
  井口登與志
- Journal Title
  
  Diabetes Frontier 17(4)
  
  Pages: 488-492
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] 糖尿病合併症の分子機構-酸化ストレスと腎症の病態2006
- Author(s)
  井口登與志
- Journal Title
  
  糖尿病学の進歩2006 40
  
  Pages: 254-258
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] NAD(P)H oxidase activation : a target for both preventing diabetic vascular complications and beta cell deterioration2005
- Author(s)
  Inoguchi T, Nawata H
- Journal Title
  
  Current Drug Targets (in press)
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Adipokines : therapeutic targets for metabolic syndrome.2005
- Author(s)
  Kobayashi K, Inoguchi T
- Journal Title
  
  Current Drug Targets 6
  
  Pages: 525-529
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Potential new therapeutic strategies of diabetic vascular complications.2005
- Author(s)
  Inoguchi T.
- Journal Title
  
  Current Drug Targets 64
  
  Pages: 445-446
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type I receptor blocker2005
- Author(s)
  Sonta T, Inoguchi T, Matsumoto S, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications (in press)
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] NAD(P)H oxidase activation : a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.2005
- Author(s)
  Inoguchi T, Nawata H
- Journal Title
  
  Curr Drug Targets. 6
  
  Pages: 495-501
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] NAD(P)H oxidase activation : a potential target mechanism for diabetic vascular complications, progressive β-cell dysfunction and metabolic syndrome.2005
- Author(s)
  Inoguchi T, et al.
- Journal Title
  
  Current Drug Targets 64
  
  Pages: 495-501
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6-a role of NAD(P)H oxidase in β-cells2005
- Author(s)
  Tsubouchi H, Inoguchi T, Inuo M, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 326
  
  Pages: 60-65
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity2004
- Author(s)
  Sonta, T, Inoguchi, T, Tsubouchi, H, Sekiguchi, N, Kobayashi, K, Matsumoto, S, Utsumi, H, Nawata, H
- Journal Title
  
  FREE RADICAL BIOLOGY AND MEDICINE 37(1)
  
  Pages: 115-123
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesitv2004
- Author(s)
  Sonta, T, Inoguchi, T, Tsubouchi, H, Sekiguchi, N, Kobayashi, K, Matsumoto, S, Utsumi, H, Nawata, H
- Journal Title
  
  Free Radic Biol Med 37
  
  Pages: 115-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement-Role of protein kinase2004
- Author(s)
  Sonta T, Inoguchi T, Tsubouchi H, et al.
- Journal Title
  
  Diabetes Research and Clinical Practice 66(1)
  
  Pages: 109-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement-Role of protein kinase C-2004
- Author(s)
  Sonta T, Inoguchi T, Tsubouchi H, et al.
- Journal Title
  
  Diabetes Research and Clinical Practice 66(1)
  
  Pages: 109-113
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Resistin : A matter of mice and men2004
- Author(s)
  Kobayashi K, Inoguchi T, Nawata H
- Journal Title
  
  Recent Res.Devel.Physiol 2
  
  Pages: 331-336
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity2004
- Author(s)
  Sonta T, Inoguchi T, Tsubouchi H, et al.
- Journal Title
  
  Free Radical Biology & Medicine 37(1)
  
  Pages: 115-123
- Data Source
  KAKENHI-PROJECT-16590888
[Journal Article] Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.2003
- Author(s)
  Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., Utsumi, H.
- Journal Title
  
  Free Radic Res 37
  
  Pages: 767-772
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes : role of vascular NAD(P)H oxidase.2003
- Author(s)
  Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., Nawata, H.
- Journal Title
  
  J Am Soc Nephrol 14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105

1. NAKAMUTA Makaoto (00294918)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KOTOH Kazuhiro (80289579)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ENJOJI Munechika (20253411)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOBAYASHI Kunihisa (30335963)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. UTSUMI Hideo (20101694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. TAKESHITA Akira (30038814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YASUI Hisataka (20089923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOGA Noboru (60161890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRATA Hiroshi (60250958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKASHIMA Naoki (60325529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 梅田文夫 (80150431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 輿石一郎 (20170235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 門司晃 (00294942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

INOGUCHI Toyoshi 井口 登與志

Research Projects

Research Products

Co-Researchers

Evaluation of fatty acid metabolism-related gene expression in non-alcoholic fatty liver disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New therapeutic strategy for diabetic complications targeting NAD(P)H oxidase activation mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of phospholipid phsophatase in insulin signaling system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nobel Strategy of Treatment for Non-alcoholic Steatohepatits

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Abnormality of protein kinase C activity and gap junction activity in diabetic vascular tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ、別冊酸化ストレス(ver.2)-フリーラジカル医学生物学の最前線、糖尿病における酸化ストレス亢進とその機序-血管壁NAD(P)Hオキシダーゼとミトコンドリアの役割.349-3512006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] 糖尿病性腎症の成因と心血管障害への関与とその対策-酸化ストレスとPKC2006

Author(s)

Journal Title

Data Source

[Journal Article] 糖尿病性腎症治療の新しい展望-抗酸化薬2006

Author(s)

Journal Title

Data Source

[Journal Article] 糖尿病合併症の分子機構-酸化ストレスと腎症の病態2006

Author(s)

Journal Title

Data Source

[Journal Article] NAD(P)H oxidase activation : a target for both preventing diabetic vascular complications and beta cell deterioration2005

Author(s)

Journal Title

Data Source

[Journal Article] Adipokines : therapeutic targets for metabolic syndrome.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Potential new therapeutic strategies of diabetic vascular complications.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type I receptor blocker2005

Author(s)

Journal Title

Data Source

[Journal Article] NAD(P)H oxidase activation : a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.2005

Author(s)

Journal Title

Description

Data Source

INOGUCHI Toyoshi 井口登與志