TAJIMA Youichi 田島陽一

… Alternative Names

Researcher Number	00300955
Other IDs
Affiliation (Current)	2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2016 – 2018: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2012: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2011: 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2010: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 2005 – 2006: (財)東京都医学研究機構, 臨床遺伝学研究部門, 研究員 … More
Review Section/Research Field	Principal Investigator Structural biochemistry / Experimental pathology / Basic Section 50010:Tumor biology-related Except Principal Investigator Functional biochemistry / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator 糖転移酵素 / 細胞融合 / dormancy / 癌悪性化 / カルネキシン / カルレティキュリン / 小胞体 / 糖脂質 / 癌抑制遺伝子 / 大腸癌 … More Except Principal Investigator ガングリオシド / 細胞接着分子 / シグナル伝達 / カベオラ / SOX17 / SOX18 / チロシンチナーゼ / チロシンキナーゼ / ラフト / 生殖腺 / ganglioside / tyrosine kinase / cell adhesion molecule / signal transduction / raft / caveolae / 血管形成 / 遺伝子改変マウス / モデル動物 / angiogenesis / Knockout mice / animal model Less

ニッチ細胞と癌細胞とのハイブリッド形成および癌多様性獲得に寄与する遺伝子の探索Principal InvestigatorOngoing
- Principal Investigator
  
  田島陽一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
発がんに関与する融合遺伝子形成における細胞融合の役割Principal InvestigatorOngoing
- Principal Investigator
  
  田島陽一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Immune tolerant Fabry mouse by liver restricted expression become the inevitable material to study efficacy in enzyme replacement therapy with a modified .-N-acetylgalactosaminidasePrincipal Investigator
- Principal Investigator
  
  TAJIMA Youichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Redundant roles of Sox17 and Sox18 on cardiovascular development in mice
- Principal Investigator
  
  KANAI Yoshiakira
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
筋ジストロフィー原因蛋白によるジストログリカン糖鎖修飾とECMとの関係Principal Investigator
- Principal Investigator
  
  田島陽一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
糖脂質の糖鎖に多様性を生み出す糖転移酵素遺伝子のクローニングと機能解析Principal Investigator
- Principal Investigator
  
  田島陽一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
神経発生分化のおけるジシアロガングリオシドの役割
- Principal Investigator
  
  SANAI Yutaka
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
GD3 Ganglioside, Expression, Modification and its Biological Function
- Principal Investigator
  
  SANAI Yutaka
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH

All 2017 2016 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Combined replacementeffectsofhumanmodified β-hexosaminidaseB and GM2activatorproteinonGM2gangliosidoses fibroblasts2016
- Author(s)
  Kitakaze K, Tasaki C, Tajima Y, Hirokawa T, Tsuji D, Sakuraba H, Itoh K
- Journal Title
  
  Biochemistry and　Biophysics　Reports
  
  Volume: 7 Pages: 157-163
- DOI
  10.1016/j.bbrep.2016.04.012
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293120, KAKENHI-PROJECT-16K15262
[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase responsive to pharmacological chaperones2011
- Author(s)
  Tajima Y, et al
- Journal Title
  
  J. Hum. Genet
  
  Volume: 56 Pages: 440-446
- DOI
  10.1038/jhg.2011.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314, KAKENHI-PROJECT-22590373
[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase Responsive to pharmacological cheperones.2011
- Author(s)
  Y.Tajima
- Journal Title
  
  Journal of Human Genetics
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590373
[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase Responsive to pharmacological cheperones2011
- Author(s)
  Y.Tajima
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 56 Pages: 440-446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590373
[Journal Article] Molecular mechanism for stabilization of a mutant a-galactosidase A involving M51I amino acid substitution by iminosugars
- Author(s)
  T. Tsukimura, Y. Chiba, K. Ohno, S. Saito, Y. Tajima, H. Sakuraba
- Journal Title
  
  Mol. Genet. Metab
  
  Volume: 103 Pages: 26-32
- DOI
  10.1016/j.ymgme.2011.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590373
[Presentation] がんと間葉系幹細胞との融合における形質変化の解析2017
- Author(s)
  田島陽一、芝崎太
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15262
[Presentation] 細胞融合により形成された異種間融合細胞癌細胞による癌増悪化への関与2016
- Author(s)
  田島陽一、梶原直樹、貞任大地、芝崎　太
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K15262
[Presentation] 治療用ヒト組み換えタンパク質によるマウスでのアナフィラキシーとサイトカインの解析2012
- Author(s)
  田島陽一
- Organizer
  第6回感染症サイトカイン研究会
- Place of Presentation
  神戸
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-22590373
[Presentation] 新規ファブリー病治療薬であるヒト改変型NAGAによる免疫応答を軽減させた免疫寛容ファブリーマウスの開発2011
- Author(s)
  田島陽一, 横山清司, 川島育夫, 貞任大地, 設楽浩志, 多屋長治, 月村考宏, 櫻庭均, 廣井隆親,芝崎太
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590373
[Presentation] 免疫寛容ファブリー病モデルマウスを用いた新規ファブリー病酵素補充療法の検討2011
- Author(s)
  田島陽一, 横山清司, 川島育夫, 貞任大地, 設楽浩志, 多屋長治, 月村考宏, 廣井隆親, 芝崎太, 櫻庭均
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590373
[Presentation] 分子設計によるファブリー病に対する新しい酵素薬の開発2010
- Author(s)
  田島陽一、川島育夫、月村考宏、千葉靖典、芝崎太、櫻庭均
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590373
[Presentation] 分子設計によるファブリー病に対する新しい酵素薬の開発2010
- Author(s)
  田島陽一
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会・合同年会
- Place of Presentation
  ポートアイランド(神戸)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22590373

1. SANAI Yutaka (40150289)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KASAHARA Kohji (60250213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 霜田靖 (00291154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 星野真人 (40212196)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAWASHIMA Ikuo (40146824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. KANAI Yoshiakira (30260326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUROHMARU Masamichi (00148636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAYA Chouji (90175456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 芝崎太 (90300954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TSUJI Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 広川貴次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤孝司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAJIMA Youichi 田島 陽一

田島 陽一 タジマ ヨウイチ

TAJIMA Youich 田島 陽一

Research Projects

Research Products

Co-Researchers

ニッチ細胞と癌細胞とのハイブリッド形成および癌多様性獲得に寄与する遺伝子の探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発がんに関与する融合遺伝子形成における細胞融合の役割Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immune tolerant Fabry mouse by liver restricted expression become the inevitable material to study efficacy in enzyme replacement therapy with a modified .-N-acetylgalactosaminidasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Redundant roles of Sox17 and Sox18 on cardiovascular development in mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

筋ジストロフィー原因蛋白によるジストログリカン糖鎖修飾とECMとの関係Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖脂質の糖鎖に多様性を生み出す糖転移酵素遺伝子のクローニングと機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経発生分化のおけるジシアロガングリオシドの役割

Principal Investigator

Project Period (FY)

Research Category

Research Institution

GD3 Ganglioside, Expression, Modification and its Biological Function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Combined replacementeffectsofhumanmodified β-hexosaminidaseB and GM2activatorproteinonGM2gangliosidoses fibroblasts2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase responsive to pharmacological chaperones2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase Responsive to pharmacological cheperones.2011

Author(s)

Journal Title

Data Source

[Journal Article] Biochemical and structural study on a S529V mutant acid α-glucosidase Responsive to pharmacological cheperones2011

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanism for stabilization of a mutant a-galactosidase A involving M51I amino acid substitution by iminosugars

Author(s)

Journal Title

DOI

Data Source

[Presentation] がんと間葉系幹細胞との融合における形質変化の解析2017

Author(s)

Organizer

Data Source

TAJIMA Youichi 田島陽一

田島陽一タジマヨウイチ

TAJIMA Youich 田島陽一