HONDA Shigenori 本田繁則

Researcher Number	00303959
Affiliation (based on the past Project Information) *help	2015 – 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2010 – 2011: National Cardiovascular Center Research Institute, 分子病態部, 室長 2009: National Cardiovascular Center Research Institute, 病因部, 室長 2005 – 2008: 国立循環器病センター(研究所), 病因部, 室長 … More 2007: National Cardiovascular Center Research Institute, 病因部, Senior, staff 1999 – 2003: Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 1998: Osaka University Medical School, Assistant Professor, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology / Hematology
Keywords	Principal Investigator インテグリン / αvβ3 / integrin / dominant negative effect / ligand-binding site / αVβ3 / PS / CL / aPL / annexin V … More / β2GPI / APS / ILK / シグナル伝達 / β3インテグリン / platelet / signaling molecule / 血小板 / シグナル伝達分子 / 細胞機能抑制効果 / リガンド結合機能 / リガンド結合部位 / ドミナントネガティブ効果 / リガント結合部位 / β３インテグリン / クローニング … More Except Principal Investigator NCX / ADAMTS13 / 血小板 / インテグリン / genetic polymorphism / thrombosis / endothelial cells / genetic engineered mouse / von Willbrand factor / Thrombocytopenia / Platelet / 血管障害 / 腎傷害 / 微小血管 / メタロプロテアーゼ / 臨床検査法 / 一般住民 / 性差 / 血栓性血小板減少性紫斑病 / 遺伝子解析 / 遺伝子多型 / 血栓 / 血管内皮細胞 / 遺伝子改変マウス / フォンビルブランド因子 / 血小板減少症 / Inside-out signaling / Megakaryocyte / β_3 integrin / CD47 / IAP / 機能欠失変異 / リガンド結合能 / 機能活性化機構 / 活性化シグナル / Inside-outシグナル / 巨核球 / β3インテグリン / signal transduction / platelets / integrin / alpha IIb beta3 / シグナル伝達 / αIIbβ3 Less

Elucidation of the role of kindlin in the functional expression of beta3 integrins and investigation of the kindlin-related new moleculesPrincipal Investigator
- Principal Investigator
  
  Honda Shigenori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the role of ILK in the functional expression of beta3 integrins and investigation of the ILK-related moleculesPrincipal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Cloning and analysis of molecules involved in functional regulation of β3 integrinPrincipal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Identification of signaling molecules associated with β3 integrins using random mutagenesisPrincipal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Studies on causative gene for thrombotic thrombocytopenic purpura, ADAMTS13
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Analyses of inhibitory effects induced by the loss-of-function mutant integrin cellular functionsPrincipal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Regulatory mechanism of β3 integrin function via signaling molecules
- Principal Investigator
  
  TOMIYAMA Yoshiaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Structural and functional analyzes of integrin αvβ3 : identification of ligand-binding sites in the αv subunit of αvβ3 and development of inhibitor for αvβ3Principal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Mechanisms of autoantibody-mediated pathological thrombosis in the mouse model with antiphospholipid symdromePrincipal Investigator
- Principal Investigator
  
  HONDA Shigenori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Signaling through integrin alpha IIb beta3
- Principal Investigator
  
  TOMIYAMA Yoshiaki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University

All 2018 2016 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] Annual Review血液20102010
- Author(s)
  冨山佳昭、本田繁則
- Total Pages
  8
- Publisher
  中外医薬社
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.2018
- Author(s)
  Morikawa Y, Kato H, Kashiwagi H, Nishiura N, Akuta K, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Thromb Res.
  
  Volume: 162 Pages: 44-52
- DOI
  10.1016/j.thromres.2017.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09454, KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-18K08327, KAKENHI-PROJECT-16K09826
[Journal Article] Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation.2016
- Author(s)
  Kato H, Nakazawa Y, Kurokawa Y, Kashiwagi H, Morikawa Y, Morita D, Banno F, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Blood
  
  Volume: 128 Issue: 23 Pages: 2729-2733
- DOI
  10.1182/blood-2016-03-704825
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461403, KAKENHI-PROJECT-26461420, KAKENHI-PROJECT-26461444, KAKENHI-PROJECT-15K09454, KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-16K09826, KAKENHI-PROJECT-16K09835
[Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.2016
- Author(s)
  Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lammle B, Miyata T
- Journal Title
  
  Int J Hematol
  
  Volume: 103 Issue: 3 Pages: 283-291
- DOI
  10.1007/s12185-015-1933-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-15K18510
[Journal Article] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK2013
- Author(s)
  Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Exp Hematol.
  
  Volume: 41(1) Issue: 1 Pages: 79-90
- DOI
  10.1016/j.exphem.2012.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-23591430, KAKENHI-PROJECT-23659488, KAKENHI-PROJECT-24591422
[Journal Article] Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.2012
- Author(s)
  Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
- Journal Title
  
  Blood
  
  Volume: 120(7) Issue: 7 Pages: 1499-1509
- DOI
  10.1182/blood-2012-02-409995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-23591430, KAKENHI-PROJECT-23659488, KAKENHI-PROJECT-24591422
[Journal Article] 「キンドリンとインテグリン活性化」Annual Review 血液2010(高久史麿・小澤敬也・坂田洋一・金倉譲・小島勢二編集)2010
- Author(s)
  冨山佳昭、本田繁則
- Journal Title
  
  中外医学社
  
  Pages: 160-167
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Biochem Biophys2010
- Author(s)
  T.Ohmori, Y.Kashiwakura, A.Ishiwata, S.Madoiwa, J.Mimuro, S.Honda, T.Miyata, Y.Sakata.
- Journal Title
  
  Res Commun 400
  
  Pages: 323-328
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Integrin-linked kinase associated with integrin activation2009
- Author(s)
  S. HONDA
- Journal Title
  
  Blood (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] 変異導入法を用いた血小板インテグリンαIIbβ3の機能調節に関わる分子の探索2009
- Author(s)
  本田繁則, 他
- Journal Title
  
  日本血栓止血学会誌 20巻
  
  Pages: 615-621
- NAID
  10026118398
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Integrin-linked kinase associated with integrin activation2009
- Author(s)
  S.HONDA, et al.
- Journal Title
  
  Blood VOL.113
  
  Pages: 5304-5313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] 変異導入法を用いた血小板インテグリンαIIbβ3の機能調節に関わる分子の探索2009
- Author(s)
  本田繁則、池島-城谷裕子、松田泰幸、田所誠司、前田祐輔、木下タロウ、冨山佳昭、宮田敏行
- Journal Title
  
  日本血栓止血学会誌 20(6)
  
  Pages: 615-621
- NAID
  10026118398
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Integrin-linked kinase associated with integrin activation.2009
- Author(s)
  S.Honda, Shirotani-Ikejima H, S.Tadokoro, Y.Maeda, T.Kinoshita, Y.Tomiyama, T.Miyata
- Journal Title
  
  Blood 113
  
  Pages: 5304-5313
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] Blood Coagul2009
- Author(s)
  J.Ishikawa, H.Okada, H.Kato, S.Takeshita, S.Honda, T.Kawasaki, E.Suehisa, H.Tsuji, S.Madoiwa, Y.Sakata, T.Kojima, M.Murata, Y.Ikeda, Y.Kokubo, T.Okamura, H.Tomoike, T.Miyata
- Journal Title
  
  Fibrinolysis 20
  
  Pages: 22-26
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article]2008
- Author(s)
  T.Miyata, Y.Sato, J.Ishikawa, H.Okada, S.Takeshita, T.Sakata, K.Kokame, R.Kimura, S.Honda, T.Kawasaki, E.Suehisa, H.Tsuji, S.Madoiwa, Y.Sakata, T.Kojima, M.Murata, Y.Ikeda.
- Journal Title
  
  Thromb Res 124
  
  Pages: 14-18
- Data Source
  KAKENHI-PROJECT-20591162
[Journal Article] A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency.2007
- Author(s)
  Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, Kawasaki T, Tsuji H, Kojima T, Madoiwa S, Sakata Y, Murata M, Ikeda Y, Miyata T
- Journal Title
  
  Thromb Haemost 98-4
  
  Pages: 783-789
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency.2007
- Author(s)
  Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, Kawasaki T, Tsuji H, Kojima T, Madoiwa S, Sakata Y, Murata M, Ikeda Y, Miyata T
- Journal Title
  
  Thromb Haemost 98
  
  Pages: 783-789
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.2007
- Author(s)
  Kimura R, Miyashita K, Kokubo Y, Akaiwa Y, Ryoichi O, Nagatsuka K, Otsuki T, Okayama A, Minematsu K, Naritomi H, Honda S, Tomoike H, Miyata T
- Journal Title
  
  Thromb Res 120
  
  Pages: 181-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Genotypes of vitamin K epoxide reductase,γ-glutamyl carboxylase,andcytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.2007
- Author(s)
  Kimura R, , Miyashita K, Kokubo Y, Akaiwa Y, Ryoichi O, Nagatsuka K, Otsuki T, Okayama A, Minematsu K, Naritomi H, Honda S, Tomoike H, Miyata T
- Journal Title
  
  Thromb Res 120
  
  Pages: 181-186
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.2006
- Author(s)
  F Banno, K Kokame, T Okuda, S Honda, S Miyata, H Kato,Y Tomiyama, T Miyata
- Journal Title
  
  Blood 107-8
  
  Pages: 3161-3166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thiombotic thrombocytopenic purpura.2006
- Author(s)
  F. Banno, K. Kokame, T. Okuda, S. Honda, S. Miyata, H. Kato, Y. Tomiyama, T. Miyata
- Journal Title
  
  Blood 107-8
  
  Pages: 3161-3166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Genotypes of vitamin K epoxide reductase,gammma-glutamyl carboxylase,and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.2006
- Author(s)
  Kimura R, Miyashita K, KokuboY, Akaiwa Y, Otsubo R, Nagatsuka K, Otsuki T, Okayama A, Minematsu K, NaritomiH, Honda S, Tomiike H, Miyata T
- Journal Title
  
  Thromb Res Epub
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Polymorphisms in vitamin K-dependent γ-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in general population.2006
- Author(s)
  Kimura R, Kokubo Y, Miyashita K, Otsubo R, Nagatsuka K, Otsuki T, Sakata T, Nagura J, Okayama A, Minematsu K, Naritomi H, Honda S, Sato K, Tomoike H, Miyata T
- Journal Title
  
  Int J Hematol 84・5
  
  Pages: 387-397
- NAID
  10018670791
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Adiponectin acts as an endogenous antithrombotic factor2006
- Author(s)
  Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T, Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y
- Journal Title
  
  Arterioscler Thromb Vasc Biol 26・1
  
  Pages: 224-230
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients.2006
- Author(s)
  R.Kimura, S.Honda, T.Kawasaki, H.Tsuji, S.Madoiwa, Y.Sakata, T.Kojima, M.Murata, K.Nishigami, M.Chiku, T.Hayashi, Y.Kokubo, A.Okayama, H.Tomoike, Y.Ikeda.T.Miyata.
- Journal Title
  
  Blood 107(4)
  
  Pages: 1737-1738
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.2006
- Author(s)
  Banno F, Kokame K, Okuda T, Honda S, Miyata S, Kato h, Tomiyama Y, Mjyata T
- Journal Title
  
  Blood 107・8
  
  Pages: 3161-3166
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients.2006
- Author(s)
  Kimura R, Honda S, Kawasaki T, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Nishigami K, Chiku M, Hayashi T, Kokubo Y, Okayama A, Tomoike H, Ikeda Y, Miyata T
- Journal Title
  
  Blood 107
  
  Pages: 1737-1738
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Complete dificiency in ADAMTS13 is prothrombotic,but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.2006
- Author(s)
  Banno F, Kokame K, Okuda T, Honda S, Miyata S, Kato H, Tomiyama Y, Miyata T
- Journal Title
  
  Blood 107
  
  Pages: 3161-3166
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients.2006
- Author(s)
  Kimura R, Honda S, Kawasaki T, Tsuji H, MadoiwaT S, Sakata Y, Kojima T, Murata M, Nishigami K, Chiku M, Hayashi T, Kokubo Y, Okayama A, Tomoike H, Ikeda Y, Miyata T
- Journal Title
  
  Blood 107・4
  
  Pages: 1737-1738
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Adiponectin acts as an endogenous antithrombotic factor.2006
- Author(s)
  Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T,Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y
- Journal Title
  
  Anterioscler Thromb Vasc Biol 26-1
  
  Pages: 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura2006
- Author(s)
  F.Banno, K.Kokame, T.Okuda, S.Honda, S.Miyata, H.Kato, Y.Tomiyama, T.Miyata.
- Journal Title
  
  Blood 107(in press)
- Data Source
  KAKENHI-PROJECT-17390285
[Presentation] The association of PAR4 polymorphism with human platelet reactivity in Japanese.2016
- Author(s)
  Morikawa Y, Kato H, Akuta K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09463
[Presentation] トロンビン受容体PAR4多型性の血小板機能における意義2016
- Author(s)
  森川洋一郎, 加藤　恒, 芥田敬吾,　柏木浩和, 本田繁則, 金倉　譲, 冨山佳昭
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K09463
[Presentation] Primary ITP患者の血小板関連抗αIIbβ3抗体のエピトープに関する検討2013
- Author(s)
  清水一亘，柏木浩和，加藤　恒，田所誠司，本田繁則，金倉　譲，冨山佳昭
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  山形県
- Data Source
  KAKENHI-PROJECT-23591430
[Presentation] ヒト巨核球株CMKにおけるαIIbβ3の活性化にはagonist, talin-1, kindlin-3が必須である2012
- Author(s)
  中澤剛士、田所誠司、清水一亘、柏木浩一、本田繁則、金倉　譲、冨山佳昭
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23591430
[Presentation] Role of ILK-PINCH-parvin complex in supporting functional expression of integrin2011
- Author(s)
  Shigenori Honda, Hiroko Shirotani-Ikejima, Yasuyuki Matsuda, Seiji Tadokoro, Yoshiaki Tomiyama, and Toshiyuki Miyata
- Organizer
  XXIII Congress of The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591430
[Presentation] An RNAi screening to identify the molecules involved in integrin αIIbβ3 activation2011
- Author(s)
  Yasuyuki Matsuda, Shigenori Honda, and Toshiyuki Miyata
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591430
[Presentation] インテグリン活性化におけるintegrin-linked kinaseの役割2010
- Author(s)
  本田繁則、池島裕子、松田泰幸、田所誠司、冨山佳昭、宮田敏行
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-20591162
[Presentation] XXII Congress of The International Society on Thrombosis and Haemostasis2009
- Author(s)
  本田繁則, 池島-城谷裕子, 田所誠司, 前田祐輔, 木下タロウ, 冨山佳昭, 宮田敏行
- Organizer
  Integrin-linked kinase associated with integrin activation
- Place of Presentation
  Boston Convention & Exhibition Center (MA USA)
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-20591162
[Presentation] Integrin-linked kinase associated with integrin activation2009
- Author(s)
  S.HONDA
- Organizer
  XXII Congress of The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston Convention & Exhibition Center(MA USA)
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-20591162
[Presentation] 発現クローニングによるインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則
- Organizer
  第31回日本血栓止血学会学術集会SPCシンポジウム
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-20591162
[Presentation] 変異導入法を用いたインテグリン機能発現分子の同定2008
- Author(s)
  本田繁則、池島-城谷裕子、田所誠司、前田祐輔、木下タロウ、冨山佳昭、宮田敏行
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-20591162
[Presentation] A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency.2007
- Author(s)
  Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, Kawasaki T, Tsuji H, Kojima T, Madoiwa S, Sakata Y, Murata M, Ikeda Y, Miyata T
- Organizer
  Congress of the Japanese Society on Thrombosis Hemostasis
- Place of Presentation
  Mie
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Presentation] A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency.2007
- Author(s)
  Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, Kawasaki T, Tsuji H, Kojima T, Madoiwa S, Sakata Y, Murata M, Ikeda Y, Miyata T
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島宝生苑・志摩観光ホテル
- Year and Date
  2007-11-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Presentation] Effects of complete deficiency and C-terminal deletion of ADAMTS13 on hemostatic function in mice2007
- Author(s)
  Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata
- Organizer
  International Mammalian Genome Conference 2007
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Presentation] Effects of complete deficiency and C-terminal deletion of ADAMTS13 on hemostatic function in mice2007
- Author(s)
  Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata
- Organizer
  International Mammalian Genome Conference
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591095
[Presentation] インテグリンαIIbβ3機能発現におけるIntegrin-linked kinaseの役割
- Author(s)
  本田繁則, 池島裕子, 田所誠司, 冨山佳昭, 宮田敏行
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-23591430
[Presentation] インテグリンαIIbβ3活性化変異, αIIb (R990W) ノックインマウスの解析
- Author(s)
  清水一亘, 柏木浩和, 森川陽一郎, 加藤　恒, 田所誠司, 坂野史明, 小亀浩市, 本田繁則, 金倉　譲, 宮田敏行, 冨山佳昭
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-23591430

1. TOMIYAMA Yoshiaki (80252667)

# of Collaborated Projects: 9 results

# of Collaborated Products: 23 results
2. MIYATA Toshiyuki (90183970)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. KASHIWAGI Hirokazu

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KANAKURA Yuzuru (20177489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KURATA Yoshiyuki (80127224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ORITANI Kenji (70324762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYATA Shigeki (20239411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. KOKAME Koichi (40270730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. BANNO Fumiaki (00373514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. SHIRAGA Masamichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Ikejima Hiroko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TADOKORO Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 加藤恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

HONDA Shigenori 本田 繁則

Research Projects

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Co-Researchers

Elucidation of the role of kindlin in the functional expression of beta3 integrins and investigation of the kindlin-related new moleculesPrincipal Investigator

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Elucidation of the role of ILK in the functional expression of beta3 integrins and investigation of the ILK-related moleculesPrincipal Investigator

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Cloning and analysis of molecules involved in functional regulation of β3 integrinPrincipal Investigator

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Identification of signaling molecules associated with β3 integrins using random mutagenesisPrincipal Investigator

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Studies on causative gene for thrombotic thrombocytopenic purpura, ADAMTS13

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Analyses of inhibitory effects induced by the loss-of-function mutant integrin cellular functionsPrincipal Investigator

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Regulatory mechanism of β3 integrin function via signaling molecules

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Structural and functional analyzes of integrin αvβ3 : identification of ligand-binding sites in the αv subunit of αvβ3 and development of inhibitor for αvβ3Principal Investigator

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Mechanisms of autoantibody-mediated pathological thrombosis in the mouse model with antiphospholipid symdromePrincipal Investigator

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Signaling through integrin alpha IIb beta3

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[Book] Annual Review血液20102010

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[Journal Article] Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.2018

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[Journal Article] Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation.2016

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[Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.2016

HONDA Shigenori 本田繁則