KOGAKI Shigetoyo 小垣滋豊

… Alternative Names

小垣滋豊コガキシゲトヨ

Less

Researcher Number	00311754
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教員 2025: 地方独立行政法人大阪府立病院機構大阪急性期・総合医療センター(臨床研究支援センター), 小児科・新生児科, 主任部長
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教員 2017 – 2021: 大阪大学, 医学系研究科, 招へい教員 2016: 大阪大学, 医学系研究科, 講師 2015: 大阪大学, 医学(系)研究科(研究院), 講師 2014: 大阪大学, 医学系研究科, 講師 2011 – 2013: 大阪大学, 医学(系)研究科(研究院), 講師 2003: Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 53020:Cardiology-related / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Embryonic/Neonatal medicine / Pediatrics
Keywords	Principal Investigator 肺高血圧症 / iPS細胞 / 心筋線維芽細胞 / 拘束型心筋症 / 粘弾性 / 肺血管拡張薬 / 原子間力顕微鏡 / 肺動脈平滑筋細胞 / 肺動脈性肺高血圧症 / 遺伝子治療 … More / 小児循環器学 / PAH / cGMP / ナトリウム利尿ペプチド受容体 / CNP … More Except Principal Investigator LSKL / TGF-β / 拘束型心筋症 / RNA-seq / 拡張型心筋症 / 心臓移植 / 遺伝子発現解析 / 心筋細胞 / 心筋線維芽細胞 / 心筋症 / Bleomycin / Pulmonary Fibrosis / ブレオマイシン / 肺線維化 / 心不全 / cyclic GMP / CNP / NPR-B Less

心筋細胞と心筋線維芽細胞の相互作用に着目した拘束型心筋症・心室拡張障害の病態解明Principal Investigator
- Principal Investigator
  
  小垣滋豊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
In vitro pharmacological assessment of pulmonary arterial hypertension by atomic force microscopyPrincipal Investigator
- Principal Investigator
  
  Kogaki Shigetoyo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Pathological functions of cardiac fibroblasts in pediatric cardiomyopathy
- Principal Investigator
  
  ISHII RYO
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Multiple development of treatment for pulmonary arterial hypertension by constitutive active natriuretic peptide receptorPrincipal Investigator
- Principal Investigator
  
  Kogaki Shigetoyo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Overexpression of constitutively active NPR-B inhibits cardiac hypertrophy
- Principal Investigator
  
  OKADA YOKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension.Principal Investigator
- Principal Investigator
  
  KOGAKI Shigetoyo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
Effect of A Blocking Peptide for Activation of Latent TGF-β In Prevention of Pulmonaiy Fibrosis.
- Principal Investigator
  
  WADA Kazuko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka University

All 2021 2020 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Cardiac Fibroblasts Play Pathogenic Roles in Idiopathic Restrictive Cardiomyopathy2021
- Author(s)
  Tsuru Hirofumi、Ishida Hidekazu、Narita Jun、Ishii Ryo、Suginobe Hidehiro、Ishii Yoichiro、Wang Renjie、Kogaki Shigetoyo、Taira Masaki、Ueno Takayoshi、Miyashita Yohei、Kioka Hidetaka、Asano Yoshihiro、Sawa Yoshiki、Ozono Keiichi
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 5 Pages: 677-686
- DOI
  10.1253/circj.CJ-20-1008
- NAID
  130008028981
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-04-23
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07789, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K17561, KAKENHI-PROJECT-19H03652
[Journal Article] Atomic force microscopy identifies cellular elasticity of pulmonary arterial smooth muscle cells in a patient with idiopathic pulmonary arterial hypertension2021
- Author(s)
  Shinichi Katsuragi, Nao Tatsumi, Mizuki Matsumoto, Jun Narita, Ryo Ishii, Hidehiro Suginobe, Hirofumi Tsuru, Wang Renjie, Shigetoyo Kogaki, Keiichi Ozono, Ryosuke Tanaka, Takaharu Okajima, and Hidekazu Ishida
- Journal Title
  
  Cardiology Research
  
  Volume: 12 Issue: 4 Pages: 231-237
- DOI
  10.14740/cr1282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08276, KAKENHI-PROJECT-21H01787
[Journal Article] Prognostic predictive value of gene mutations in Japanese patients with hypertrophic cardiomyopathy.2016
- Author(s)
  Chida A, Inai K, Sato H, Shimada E, Nishizawa T, Shimada M, Furutani M, Furutani Y, Kawamura Y, Sugimoto M, Ishihara J, Fujiwara M, Soga T, Kawana M, Fuji S, Tateno S, Kuraishi K, Kogaki S, Nishimura M, Ayusawa M, Ichida F, Yamazawa H, Matsuoka R, Nonoyama S, Nakanishi T.
- Journal Title
  
  Heart Vessels
  
  Volume: Nov 24 Issue: 6 Pages: 700-707
- DOI
  10.1007/s00380-016-0920-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09690
[Journal Article] Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension.2016
- Author(s)
  Nawa N, Ishida H, Katsuragi S, Baden H, Takahashi K, Higeno R, Torigoe F, Mihara S, Narita J, Miura K, Nakamura K, Kogaki S, Ozono K.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 3 Pages: 16044-16044
- DOI
  10.1038/mtm.2016.44
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09690, KAKENHI-PROJECT-16K10065
[Presentation] 小児心筋症における心筋線維芽細胞の生理機能ならびに病態関与の解析2020
- Author(s)
  水流宏文, 石田秀和, 杉辺英世, 桂木慎一, 石井良, 成田淳, 上野高義, 小垣滋豊, 澤芳樹, 大薗恵一
- Organizer
  第56回日本小児循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07789
[Presentation] B型ナトリウム利尿ペプチド受容体（NPR-B）機能獲得変異体による心不全予防効果の検討2016
- Author(s)
  馬殿洋樹，桂木慎一，那波伸敏，石田秀和，成田淳，高橋邦彦，小垣滋豊，大薗恵一
- Organizer
  第52回日本小児循環器学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-15K09690
[Presentation] Intravascular injection of Sendai virus vector carrying continuously cGMP producing mutant of type B Natriuretic Peptide Receptor can ameliorate pulmonary arterial hypertension.2015
- Author(s)
  Nawa N, Ishida H, Katsuragi S, Baden H, Takahashi K, Kogaki S, Higeno R, Torigoe F, Mihara S, Narita J, Miura K, Ozono K
- Organizer
  American Heart Association (AHA) Scientific Sessions 2015
- Place of Presentation
  Orlando, Florida, United States
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09690
[Presentation] センダイウイルスベクターを用いた肺動脈性肺高血圧症(PAH)に対する新たな遺伝子治療の可能性2015
- Author(s)
  那波　伸敏、石田　秀和、馬殿　洋樹、高橋　邦彦、小垣　滋豊、廣瀬将樹、桂木慎一、髭野　亮太、三原聖子、成田淳、三浦　弘司、大薗　恵一
- Organizer
  第51回日本小児循環器学会総会・学術集会
- Place of Presentation
  ホテル日航東京
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K09690
[Presentation] Therapeutic application of constitutively active type B natriuretic peptide receptor for pulmonary arterial hypertension2015
- Author(s)
  Nawa N, Ishida H, Baden H, Takahashi K, Higeno R, Mihara S, Ishii R, Ichimori H, Yabushita-Okada Y, Miura K, Kogaki S, Ozono K
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09690
[Presentation] CNP受容体恒常活性型変異体を用いた肺高血圧症の新たな治療法2015
- Author(s)
  那波　伸敏、石田　秀和、馬殿　洋樹、桂木慎一、高橋　邦彦、小垣　滋豊、廣瀬将樹、鳥越　史子、髭野　亮太、三原聖子、成田淳、三浦　弘司、大薗　恵一
- Organizer
  第4回日本肺循環学会・第3回日本肺高血圧学会　合同学術集会
- Place of Presentation
  ステーションコンファレンス東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09690
[Presentation] 機能獲得変異型N-PRBによる心不全治療戦略2013
- Author(s)
  馬殿洋樹, 髭野亮太, 那波伸敏, 石井良, 市森裕章, 内川俊毅, 高橋邦彦, 岡田陽子, 小垣滋豊, 大薗恵一
- Organizer
  第49回日本小児循環器学会総会
- Place of Presentation
  国立オリンピック記念青少年総合センター
- Data Source
  KAKENHI-PROJECT-25461620
[Presentation] Constitutively Active NPR-B (Type-B Human Natriuretic Peptide Receptor) Inhibits Cardiomyocyte Hypertrophy and Cardiac Fibroblast Fibrosis2013
- Author(s)
  Baden H, Nawa N, Ishida H, Takahashi K, Kogaki S, Yabushita-Okada Y, Ichimori H, Ishii R, Mihara S, Higeno R, Miura K, Ozono K.
- Organizer
  AHA2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-25461620
[Presentation] Therapeutic Application of Type B Natriuretic Peptide Receptor With a Novel Gain-of-function Mutation in the Treatment of Pulmonaly Arterial Hypertension2013
- Author(s)
  Nawa N, Ishida H, Baden H, Takahashi K, Kogaki S, Yabushita-Okada Y, Ichimori H, Ishii R, Mihara S, Higeno R, Miura K, Ozono K.
- Organizer
  American Heart Association, Scientiic Sessions 2013
- Place of Presentation
  米国Dallas
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptide (CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性高血圧症(PAH)に対する新たな治療アプローチ2013
- Author(s)
  那波伸敏,石田秀和,馬殿洋樹,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,石井良,髭野亮太,岡田陽子,三浦弘司,大薗恵一
- Organizer
  第19回日本小児肺循環研究会
- Place of Presentation
  東京
- Year and Date
  2013-02-02
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] Therapeutic application of type B natriuretic peptide receptor with a novel gain-of-function mutation in the treatment of pulmonary arterial hypertension2013
- Author(s)
  Nawa N, Ishida H, Baden H, Takahashi K, Kogaki S, Yabushita-Okada Y, Ichimori H, Ishii R, Mihara S, Higeno R, Miura K, Ozono K
- Organizer
  American Heart Association, Scientiic Sessions 2013
- Place of Presentation
  Dallas, Texas（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptide(CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺高血圧症に対する新たな治療アプローチ(第3報)2013
- Author(s)
  那波伸敏,石田秀和,馬殿洋樹,高橋邦彦,小垣滋豊,市森裕章,石井良,髭野亮太,藪下陽子,三浦弘司,大薗恵一
- Organizer
  第49回日本小児循環器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptid (CNP) 受容体　(NPR-B)の昨日獲得型変異体を用いた，肺動脈性肺高血圧症(PAH)に対する新たな治療アプローチ2012
- Author(s)
  那波伸敏，石田秀和，高橋邦彦，小垣滋豊，市森裕章，内川俊毅，成田淳，前川周，岡田陽子，三浦弘司，大薗恵一
- Organizer
  第18回日本小児肺循環研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptide(CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性肺高血圧症に対する新たな治療アプローチ(第2報)2012
- Author(s)
  那波伸敏,石田秀和,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,藪下陽子,三原聖子,馬殿洋樹,三浦弘司,大薗恵一
- Organizer
  第48回日本小児循環器学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptide (CNP)受容体(NPR-B)の機能獲得型変異体を用いた,肺動脈高血圧症(PAH)に対する新たな治療アプローチ2012
- Author(s)
  那波伸敏,石田秀和,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,成田淳,岡田陽子,三浦弘司,大薗恵一
- Organizer
  第18回日本小児肺循環研究会
- Place of Presentation
  東京
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] C-type natriuretic peptide (CNP) 受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性肺高血圧症に対する新たな治療アプローチ第2報2012
- Author(s)
  那波　伸敏、石田　秀和、高橋　邦彦、小垣　滋豊、市森　裕章、内川　俊毅、藪下　陽子、三原聖子、馬殿洋樹、三浦　弘司、大薗　恵一
- Organizer
  第48回日本小児循環器学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension2011
- Author(s)
  Nobutoshi Nawa; hidekazu Ishida; Sigetoyo Kogaki; Toshiki Uchikawa; Yoko Okada; Jun Narita; Shu Maekawa; Hiroaki Ichimori; Koji Miura; Keiichi Ozono
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  米国　オーランド
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension2011
- Author(s)
  Nawa N, Ishida H, Kogaki S, Uchikawa T, Okada Y, Narita J, Maekawa S, Ichimori H, Miura K, Ozono K.
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  米国オーランド
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-23591567
[Presentation] B型ナトリウム利尿ペプチド受容体(NPR-B)の機能獲得型変異体による心不全治療戦略
- Author(s)
  馬殿洋樹, 那波伸敏, 島越史子, 三原聖子, 石井良, 市森裕章, 高橋邦彦, 岡田陽子, 小垣滋豊, 大薗恵一
- Organizer
  第50回日本小児循環器学会学術集会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-07-03 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-25461620
[Presentation] C-type natriuretic peptide (CNP) 受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性肺高血圧症(PAH)に対する新たな治療アプローチ
- Author(s)
  那波　伸敏、石田　秀和、馬殿　洋樹、高橋　邦彦、小垣　滋豊、市森　裕章、内川　俊毅、石井　良、髭野　亮太、岡田　陽子、三浦　弘司、大薗　恵一
- Organizer
  第19回日本小児肺循環研究会
- Place of Presentation
  笹川記念館
- Data Source
  KAKENHI-PROJECT-23591567

1. TAKAHASHI Kunihiko (10610230)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. ISHIDA Hidekazu (50467552)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. NAWA Nobutoshi (30617543)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ICHIMORI Hiroaki (60467553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. OKADA YOKO (30457022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. WADA Kazuko (30294094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MUSHIAKE Sohtaro (90291947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHII RYO (90794008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 松下享 (80252659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 馬殿洋樹 (60644614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 岡嶋孝治 (70280998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 那波伸俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 17 results

KOGAKI Shigetoyo 小垣 滋豊

小垣 滋豊 コガキ シゲトヨ

Research Projects

Research Products

Co-Researchers

心筋細胞と心筋線維芽細胞の相互作用に着目した拘束型心筋症・心室拡張障害の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vitro pharmacological assessment of pulmonary arterial hypertension by atomic force microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological functions of cardiac fibroblasts in pediatric cardiomyopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multiple development of treatment for pulmonary arterial hypertension by constitutive active natriuretic peptide receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Overexpression of constitutively active NPR-B inhibits cardiac hypertrophy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of A Blocking Peptide for Activation of Latent TGF-β In Prevention of Pulmonaiy Fibrosis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cardiac Fibroblasts Play Pathogenic Roles in Idiopathic Restrictive Cardiomyopathy2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Atomic force microscopy identifies cellular elasticity of pulmonary arterial smooth muscle cells in a patient with idiopathic pulmonary arterial hypertension2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic predictive value of gene mutations in Japanese patients with hypertrophic cardiomyopathy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 小児心筋症における心筋線維芽細胞の生理機能ならびに病態関与の解析2020

Author(s)

Organizer

Data Source

[Presentation] B型ナトリウム利尿ペプチド受容体（NPR-B）機能獲得変異体による心不全予防効果の検討2016

Author(s)

Organizer

Place of Presentation

Year and Date

KOGAKI Shigetoyo 小垣滋豊

小垣滋豊コガキシゲトヨ

[Presentation] センダイウイルスベクターを用いた肺動脈性肺高血圧症(PAH)に対する新たな遺伝子治療の可能性2015

[Presentation] C-type natriuretic peptid (CNP) 受容体　(NPR-B)の昨日獲得型変異体を用いた，肺動脈性肺高血圧症(PAH)に対する新たな治療アプローチ2012