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Ota Kazuhisa  太田 一寿

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OTA Kazuhisa  太田 一寿

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Researcher Number 00322727
Other IDs
Affiliation (Current) 2025: 長崎国際大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2013 – 2014: 長崎国際大学, 薬学部, 准教授
2011 – 2013: 東京大学, 理学(系)研究科(研究院), 助教
2009 – 2010: The University of Tokyo, 大学院・理学系研究科, 助教
2006: 東京大学, 大学院新領域創成科学研究科, 助手
2004 – 2005: 東京大学, 大学院・新領域創成科学研究科, 助手
2004: THE UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF FRONTIER SCIENCES, RESEARCH ASSOCIATE, 大学院新領域創成科学研究科, 助手
2000 – 2003: 金沢大学, がん研究所, 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / General medical chemistry / Genome biology / Applied genomics
Except Principal Investigator
Biological Sciences / General medical chemistry / System genome science / Genome biology
Keywords
Principal Investigator
出芽酵母 / ユビキチン / プロテオミクス / 質量分析 / CpGアイランド / 質量分析計 / 脱ユビキチン化酵素 / 翻訳後修飾 / 質量分析器 / MS … More / ユビキチン化 / M.SssI / 1ハイブリッド / ヒト21番染色体 / McrBC / HpaII / メチル化 / 酵母 / インプリント / 2ハイブリッド … More
Except Principal Investigator
DNAメチル化 / 相互作用ドメイン / 酵母2ハイブリッド法 / GIドメイン / 2ハイブリッド法 / ユビキチン / PB1ドメイン / TAPタグ / 蛋白質相互作用 / FULL LENGTH cDNA / DNA METHYLATION / MASS SPECTROMETRY / UBIQUITIN / TAP TAG / PB1 DOMAIN / YEAST 2-HYBRID SYSTEM / PROTEIN-PROTEIN INTERACTION / 出芽酵母 / 転写開始点 / 蛋白質核酸相互作用 / 1ハイブリッド法 / 蛋白質DNA相互作用 / ユビキチン化 / 質量分析法 / 蛋白質間相互作用 / 全長cDNA / 質量分析 / タンパク質間相互作用 / translational control / nutritional stress response / GCN pathway / TOR signaling / eIF2α / GCN2 / ラパマシン / TOR / 翻訳制御 / 栄養ストレス応答 / GCN経路 / TORシグナリング / SAM / レトロトランスポゾン / ミトコンドリア / ヒストンメチル化 / 適応 / トランスオミクス / 人工遺伝子回路 / 1ハイブリッドシステム / 脱メチル化 / TET2 / TET1 / 次世代シーケンサ / ヒドロキシメチル化 / ヒドロキシメチルシトシン / エピジェネティクス / 5ヒドロキシメチルシトシン / CpGアイランド / インプリンティング / PXドメイン / PBIドメイン / プロテオーム / 保証付き逆2ハイブリッド法 / SH3ドメイン / MS / LC / PAP法 Less
  • Research Projects

    (14 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (5 People)
  •  Transomic analysis of adaptation induced by a synthetic gene circuit

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      System genome science
    • Research Institution
      Kyushu University
  •  Analysis of 5-hydroxymethylcytosine: genome-wide mapping and screening for binding proteins

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Genome biology
    • Research Institution
      Kyushu University
      The University of Tokyo
  •  Systematic identification and classification of polyubiquitinated proteins with specific chain linkage patterns.Principal Investigator

    • Principal Investigator
      OTA kazuhisa
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genome biology
    • Research Institution
      Nagasaki International University
      The University of Tokyo
  •  A systematic search for potential substrates of deubiquitinase with quantitative proteomicsPrincipal Investigator

    • Principal Investigator
      OTA Kazuhisa
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied genomics
    • Research Institution
      The University of Tokyo
  •  ポリユビキチン化蛋白質の定量的プロファイリングの試みPrincipal Investigator

    • Principal Investigator
      太田 一寿
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  ポリユビキチン化基質蛋白質の網羅的同定Principal Investigator

    • Principal Investigator
      太田 一寿
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
      Kanazawa University
  •  SYSTEMATIC COLLECTION OF BASIS INFORMATION FOR PROTEIN INTERACTION PREDICTION

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  ヒトゲノム情報に基づく系統的メチル化解析によるがん関連インプリント遺伝子の検索Principal Investigator

    • Principal Investigator
      太田 一寿
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  A NOVEL MECHANISM FOR TRANSLATION CONTROL REGULATION OF GCN PATHWAY BY TOR AND GI DOMAIN PROTEINS

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      THE UNIVERSITY OF TOKYO
      Kanazawa University
  •  構造生物学研究へのゲノムリソース活用促進技術の開発Principal Investigator

    • Principal Investigator
      太田 一寿
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  ゲノム的アプローチによるがん関連遺伝子としてのインプリント遺伝子の探索Principal Investigator

    • Principal Investigator
      太田 一寿
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  蛋白質間相互作用ドメインへのゲノム的アプローチ

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  蛋白質―蛋白質相互作用情報の系統的解析

    • Principal Investigator
      伊藤 隆司
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  がん関連遺伝子候補としてのインプリント遺伝子の網羅的単離

    • Principal Investigator
      伊藤 隆司
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University

All 2014 2012 2011 2010 2009 2005 2004 2003 2002 2001 2000

All Journal Article Presentation

  • [Journal Article] Detecting protein-DNA interactions using a modified yeast one-hybrid system2014

    • Author(s)
      Kazuhisa Ota, Shu-Ying Feng, Takashi Ito
    • Journal Title

      Methods Mol Biol

      Volume: 1164 Pages: 39-50

    • DOI

      10.1007/978-1-4939-0805-9_5

    • ISBN
      9781493908042, 9781493908059
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310130, KAKENHI-PROJECT-23510233
  • [Journal Article] A yeast one-hybrid system to screen for methylated DNA-binding proteins2010

    • Author(s)
      Feng SY, Ota K, Ito T.
    • Journal Title

      Nucleic Acids Research

      Volume: 38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Journal Article] A yeast one-hybrid system to screen for methylated DNA-binding proteins.2010

    • Author(s)
      Feng SY., Ota K., Ito T.
    • Journal Title

      Nucleic Acids Res.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Journal Article] Remodeling of the SCF complex-mediated ubiquitination system by compositional alteration of incorporated F-box proteins2010

    • Author(s)
      Kato, M., Kito, K., Ota, K.Ito, T.
    • Journal Title

      Proteomics 10

      Pages: 115-123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Journal Article] Remodeling of the SCF Complex-mediated Ubiquitination System by Compositional2009

    • Author(s)
      Kato M., Kito K., Ota K., Ito T.
    • Journal Title

      Alteration of Incorporated F-box Proteins Proteomics

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Journal Article] Circular permutation of ligand-binding module improves dynamic range of genetically encoded FRET-based nanosensor.2009

    • Author(s)
      Okada S., Ota K., Ito T.
    • Journal Title

      Protein Sci.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Journal Article] The yeast eIF4E-associated protein Eap 1p attenuates GCN4 translation upon TOR inactivation2005

    • Author(s)
      Matsuo, R., Kubota, H., Obata, T., Kito, K., Ota, K., Kitazono, T., Ibayashi, S., Sasaki, T., Iida, M., Ito, T.
    • Journal Title

      FEBS Lett. 579

      Pages: 2433-2438

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast2004

    • Author(s)
      Ichimura, T., Kubota, H., Goma, T., Mizushima, N., Ohsumi, Y., Iwago, M., Kakiuchi, K., Shekhar, H.U., Shinkawa, T., Taoka, M., Ito, T., Isobe, T.
    • Journal Title

      Biochemistry 43

      Pages: 6149-6158

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors : involvement of Pdr3 in salt tolerance.2004

    • Author(s)
      Onda M, Ota K, Chiba T, Sakaki Y, Ito T.
    • Journal Title

      Gene. 332

      Pages: 51-59

    • Data Source
      KAKENHI-PROJECT-15790148
  • [Journal Article] A yeast one-hybrid system to detect methylation-dependent DNA-protein interactions2004

    • Author(s)
      Feng, S.-Y., Ota, K., Yamada, Y., Sawabu, N., Ito, T.
    • Journal Title

      Biochem.Biophys.Res.Commun 313

      Pages: 922-925

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors : involvement of Pdr3 in salt resistance2004

    • Author(s)
      Onda, M., Ota, K., Chiba, T., Sakaki, Y., Ito, T.
    • Journal Title

      Gene 332

      Pages: 51-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors : involvement of Pdr3 in salt resistance2004

    • Author(s)
      Dnda, M., Ota, K., Chiba, T., Sakaki, Y., Ito.T.
    • Journal Title

      Gene 332

      Pages: 51-59

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] A yeast one-hybrid system to detect methylation-dependent DNA-protein interactions.2004

    • Author(s)
      Feng SY, Ota K, Yamada Y, Sawabu N, Ito T.
    • Journal Title

      Biochem Biophys Res Commun. 313(4)

      Pages: 922-925

    • Data Source
      KAKENHI-PROJECT-15790148
  • [Journal Article] A yeast one-hybrid system to detect methylation-dependent DNA-protein interactions2004

    • Author(s)
      Feng, S.-Y., Ota, K., Yamada, Y., Sawabu, N., Ito, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 313

      Pages: 922-925

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN22003

    • Author(s)
      Kubota, H., Obata, T., Ota, K., Sasaki, T., Ito, T.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 20457-20460

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Molecular recognition in dimerization between PB1 domains2003

    • Author(s)
      Noda, Y., Kohjima, M., Izaki, T., Ota, K., Yoshinaga, S., Inagaki, F., Ito, T., Sumimoto, H.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 43516-43524

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2a kinase GCN22003

    • Author(s)
      Kubota, H., Obata, T., Ota, K., Sasaki, T., Ito, T.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 20457-20460

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Roles for the two-hybrid system in exploration of the yeast protein interactome2002

    • Author(s)
      Ito, T., Ota, K., Kubota, H., Yamaguchi, Y., Chiba, T., Sakuraba, K., Yoshida, M.
    • Journal Title

      Mol.Cell.Proteomics 1

      Pages: 561-566

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN22001

    • Author(s)
      Kubota, H., Ota, K., Sakaki, Y., Ito, T.
    • Journal Title

      J.Biol.Chem. 276

      Pages: 17591-17596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN22001

    • Author(s)
      Kubota, H., Ota, K., Sakaki, Y., Ito, T.
    • Journal Title

      J. Biol. Chem. 276

      Pages: 17591-17596

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions2001

    • Author(s)
      Ito, T., Matsui, Y., Ago, T., Ota, K., Sumimoto, H.
    • Journal Title

      EMBO J. 20

      Pages: 3938-3946

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] GI domain-mediated association of the eukaryotic initiation factor 2α kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast2000

    • Author(s)
      Kubota, H., Sakaki, Y., Ito, T.
    • Journal Title

      J. Biol. Chem. 275

      Pages: 20243-20246

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Journal Article] GI domain-mediated association of the eukaryotic initiation factor 2a kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast2000

    • Author(s)
      Kubota, H., Sakaki, Y., Ito, T.
    • Journal Title

      J.Biol.Chem. 275

      Pages: 20243-20246

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15014213
  • [Presentation] Ubp6によるRpn1のユビキチン化状態の制御2012

    • Author(s)
      太田一寿
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡 福岡市
    • Data Source
      KAKENHI-PROJECT-23510233
  • [Presentation] F-box protein機能の統一的理解を目指して2011

    • Author(s)
      太田一寿
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23510233
  • [Presentation] RSP5機能のユビキチン化による制御機構2010

    • Author(s)
      太田一寿、紀藤圭治、伊藤隆司
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Presentation] ミトコンドリア外膜蛋白質MDM34のユビキチン化機構2009

    • Author(s)
      太田一寿・岡田悟・伊藤隆司
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21710200
  • [Presentation] USP型脱ユビキチン化酵素の網羅的基質探索2009

    • Author(s)
      廣田剛志・太田一寿・紀藤圭治・伊藤隆司
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21710200
  • 1.  ITO Takashi (90201326)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 16 results
  • 2.  萩原 百合子 (70322732)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  SUMMOTO Hidekl (30179303)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  KITO Keiji (40345632)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YAMADA Yoichi (30377402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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