HIGASHI MORIHIRO 東守洋

… Alternative Names

Higashi Morihiro 東守洋

HIGASHI Morihiro 東守洋

東守洋ヒガシモリヒロ

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Researcher Number	00323395
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 埼玉医科大学, 医学部, 教授 2022 – 2023: 埼玉医科大学, 医学部, 教授 2019 – 2021: 埼玉医科大学, 医学部, 准教授 2015 – 2016: 埼玉医科大学, 医学部, 准教授 2011 – 2013: 埼玉医科大学, 医学部, 講師 2003 – 2005: 千葉大学, 大学院・医学研究院, 助手 2000: 千葉大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Human pathology Except Principal Investigator Biological Sciences / Metabolomics / Gastroenterology / Experimental pathology
Keywords	Principal Investigator 悪性リンパ腫 / LR11 / 治療ターゲット / 腫瘍微小環境 / 免疫微小環境 / B細胞リンパ腫 / CD24 / DLBCL / lipid droplet / 細胞内脂質代謝 … More / Lipid droplet / 細胞内脂肪滴 / 補体依存性細胞傷害 / リツキシマブ / びまん性大細胞型B細胞リンパ腫 / Matermind / 免疫組織化学 / Notchシグナル / 腫瘍発生機構 / Notch / Mastermind / B細胞性リンパ腫 / 血液 … More Except Principal Investigator CD44 / NFkB / CD44 knockout mice / RanBPM / hMena / cell motility / yeast-two hybrid / 蛋白質 / 生体分子 / 癌 / 遺伝子 / 皮下脂肪 / 可溶性LR11 / 褐色脂肪 / ノックアウトマウス / インスリン抵抗性 / 褐色分化 / 熱代謝 / 糖尿病 / 肥満 / 機能獲得 / 褐色細胞 / エネルギー消費 / LR11 / 腫瘍関連マクロファージ / Optical biopsy / Endocytoscopy system / リンパ管新生 / 超拡大内視鏡 / 血管新生 / 食道炎 / 食道癌 / エンドサイトスコピーシステム / RhoA / CD44シグナリング / Toll-like receptor / チロシンリン酸化 / FAK / Rho / マトリックスメタロプロテイアーゼ / 浸潤 / 腫瘍 / 細胞運動 Less

濾胞性リンパ腫における濾胞樹状細胞による免疫逃避機構Principal Investigator
- Principal Investigator
  
  東守洋
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Saitama Medical University
Mechanism of DLBCL tumor immune microenvironment modification initiated by CD24.Principal Investigator
- Principal Investigator
  
  東守洋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Saitama Medical University
Molecular function of LR11 in lipid metabolism of malignant lymphomaPrincipal Investigator
- Principal Investigator
  
  Higashi Morihiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Saitama Medical University
リツキシマブ細胞傷害におけるLR11の分子機構の解明Principal Investigator
- Principal Investigator
  
  東守洋
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Saitama Medical University
Im vivo observation using the endocytoscopy system (GIF-Y0002) for the esophageal lesions
- Principal Investigator
  
  Kumagai Youichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University
Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetes
- Principal Investigator
  
  JIANG Meizi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Toho University
The role of Mastermind in B-cell lymphomaPrincipal Investigator
- Principal Investigator
  
  HIGASHI Morihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Saitama Medical University
新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Molecular cloning and function of CD44 cytoplasmic domain associated molecules
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
CD44の細胞運動・転移関連遺伝子発現における役割
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 造血器腫瘍とエピジェネティクス -治療への応用と新たな展開-2012
- Author(s)
  東守洋、田丸淳一 (木崎昌弘編)
- Total Pages
  10
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] DLBCLにおけるCD24発現の意義　治療標的としての微小環境2023
- Author(s)
  東　守洋
- Journal Title
  
  血液内科
  
  Volume: 86 Pages: 142-146
- Data Source
  KAKENHI-PROJECT-22K06966
[Journal Article] Anti-neutrophil cytoplasmic antibody-negative granulomatosis with polyangiitis manifesting through pulmonary nodules and a genital lesion2023
- Author(s)
  Mikami-Saitoh Yuriko、Kyoyama Hiroyuki、Hirata Yusuke、Kikuchi Satoshi、Sakai Kosuke、Mikami Shintaro、Moriyama Gaku、Koyama Nobuyuki、Higashi Morihiro、Ishizu Akihiro、Uematsu Kazutsugu
- Journal Title
  
  Respiratory Medicine Case Reports
  
  Volume: 46 Pages: 101951-101951
- DOI
  10.1016/j.rmcr.2023.101951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06966, KAKENHI-PROJECT-21H02958
[Journal Article] HL-252 MCVAC Conditioning Regimen Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients With Relapsed and Refractory Hodgkin Lymphoma: A Single-Institution Retrospective Study2023
- Author(s)
  Naganuma Ken、Takahashi Yasuyuki、Anan Tomoe、Kubota Yasushi、Momose Shuji、Higashi Morihiro、Tamaru Jun-ichi、Kizaki Masahiro、Tabayashi Takayuki
- Journal Title
  
  Clinical Lymphoma Myeloma and Leukemia
  
  Volume: 23 Pages: S409-S409
- DOI
  10.1016/s2152-2650(23)01269-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06966
[Journal Article] <scp>CD24</scp> is a surrogate for ‘immune‐cold’ phenotype in aggressive large B‐cell lymphoma2022
- Author(s)
  Higashi Morihiro、Momose Shuji、Takayanagi Natsuko、Tanaka Yuka、Anan Tomoe、Yamashita Takahisa、Kikuchi Jun、Tokuhira Michihide、Kizaki Masahiro、Tamaru Jun‐ichi
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: March 2022 Issue: 4 Pages: 340-354
- DOI
  10.1002/cjp2.266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-22K06966
[Journal Article] Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy2022
- Author(s)
  Yano Hiromu、Fujiwara Yukio、Horlad Hasita、Pan Chang、Kai Keitaro、Niino Daisuke、Ohsawa Kumiko、Higashi Morihiro、Nosaka Kisato、Okuno Yutaka、Tamaru Jun‐ichi、Mukasa Akitake、Matsuoka Masao、Komohara Yoshihiro
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 6 Pages: 2129-2143
- DOI
  10.1111/cas.15349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06966, KAKENHI-PROJECT-20H03459, KAKENHI-PROJECT-19K07467
[Journal Article] Better method for detection of CD30: Immunohistochemistry or flow cytometry?2021
- Author(s)
  Higashi Morihiro、Kikuchi Jun、Murakami Chiaki、Takayanagi Natsuko、Momose Shuji、Kizaki Masahiro、Tamaru Jun-ichi
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 61 Issue: 4 Pages: 221-223
- DOI
  10.3960/jslrt.21019
- NAID
  130008131971
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-20K07396
[Journal Article] Fluorescent nanoparticle‐mediated semiquantitative MYC protein expression analysis in morphologically diffuse large B‐cell lymphoma2021
- Author(s)
  Takayanagi Natsuko、Momose Shuji、Kikuchi Jun、Tanaka Yuka、Anan Tomoe、Yamashita Takahisa、Higashi Morihiro、Tokuhira Michihide、Kizaki Masahiro、Tamaru Jun‐ichi
- Journal Title
  
  Pathology International
  
  Volume: 71 Issue: 9 Pages: 594-603
- DOI
  10.1111/pin.13131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-20K07396
[Journal Article] Endocytoscopic observation with methylene blue staining for duodenal neoplasms associated with familial adenomatous polyposis2020
- Author(s)
  Kumagai Youichi、Yamamoto Eisuke、Higashi Morihiro、Ishiguro Toru、Hatano Satoshi、Toyomasu Yoshitaka、Amano Kunihiko、Suzuki Okihide、Ishibashi Kei-ichiro、Mochiki Erito、Tamaru Jun-ichi、Ishida Hideyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19221-19221
- DOI
  10.1038/s41598-020-76309-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-19K08477
[Journal Article] The clinical impact of absolute lymphocyte count in peripheral blood among patients with methotrexate - associated lymphoproliferative disorders2020
- Author(s)
  Tokuhira M, Tanaka Y, Takahashi Y, Kimura Y, Tomikawa T, Anan T, Watanabe J, Sagawa M, Higashi M, Momose S, Amano K, Tabayashi T, Nakaseko R, Tamaru JI, Kizaki M.
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 60 Issue: 2 Pages: 41-50
- DOI
  10.3960/jslrt.19039
- NAID
  130007858057
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07467
[Journal Article] Decreased MYC-associated factor X (MAX) expression is a new potential biomarker for adverse prognosis in anaplastic large cell lymphoma2020
- Author(s)
  Yamashita Takahisa、Higashi Morihiro、Momose Shuji、Adachi Akiko、Watanabe Toshiki、Tanaka Yuka、Tokuhira Michihide、Kizaki Masahiro、Tamaru Jun-ichi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 10391-10391
- DOI
  10.1038/s41598-020-67500-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-20K07396
[Journal Article] Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.2020
- Author(s)
  Gimenez N, Schulz R, Higashi M, Aymerich M, Villamor N, Delgado J, Juan M, Lopez-Guerra M, Campo E, Rosich L, Seiffert M, Colomer D.
- Journal Title
  
  Leukemia.
  
  Volume: 34 Issue: 1 Pages: 100-114
- DOI
  10.1038/s41375-019-0507-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07467
[Journal Article] Endocytoscopic Observation of Non-Ampullary Mucosal Duodenal Cancer2020
- Author(s)
  Kumagai Youichi、Higashi Morihiro、Muramatsu Shunsuke、Mochiki Erito、Ishida Hideyuki
- Journal Title
  
  Case Reports in Gastroenterology
  
  Volume: 14 Issue: 1 Pages: 156-164
- DOI
  10.1159/000506930
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08477, KAKENHI-PROJECT-19K07467
[Journal Article] Abemaciclib, a CDK4/6 inhibitor, exerts preclinical activity against aggressive germinal center-derived B-cell lymphomas.2020
- Author(s)
  Tanaka Y, Momose S, Tabayashi T, Sawada K, Yamashita T, Higashi M, Sagawa M, Tokuhira M, Rosenwald A, Kizaki M, Tamaru JI.
- Journal Title
  
  Cancer Sci. 2020 Feb;111(2):
  
  Volume: 111 Issue: 2 Pages: 749-759
- DOI
  10.1111/cas.14286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-17K09939
[Journal Article] Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders2019
- Author(s)
  Tokuhira M, Saito S, Suzuki K, Higashi M, Momose S, Shimizu T, Mori T, Kimura Y, Amano K, Okamoto S, Takeuchi T, Tamaru JI, Kizaki M
- Journal Title
  
  Leuk Lymphoma
  
  Volume: - Issue: 10 Pages: 1-8
- DOI
  10.1080/10428194.2019.1585841
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08673, KAKENHI-PROJECT-19K07467
[Journal Article] Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.2019
- Author(s)
  Silkenstedt E, Arenas F, Colom-Sanmarti B, Xargay-Torrent S, Higashi M, Giro A, Rodriguez V, Fuentes P, Aulitzky WE, van der Kuip H, Bea; S, Toribio ML, Campo E, Lopez-Guerra M, Colomer D.
- Journal Title
  
  J Exp Clin Cancer Res.
  
  Volume: 38 Issue: 1 Pages: 446-446
- DOI
  10.1186/s13046-019-1458-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07467
[Journal Article] Anaplastic large cell lymphoma with TP63 rearrangement: A dismal prognosis.2019
- Author(s)
  Yamashita T, Higashi M, Kawano R, Momose S, Tokuhira M, Kizaki M, Tamaru JI
- Journal Title
  
  Pathol Int
  
  Volume: 69(3) Issue: 3 Pages: 155-159
- DOI
  10.1111/pin.12758
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08673, KAKENHI-PROJECT-19K07467
[Journal Article] A newly developed continuous zoom-focus endocytoscope.2017
- Author(s)
  Kumagai Y, Takubo K, Kawada K, Higashi M, Ishiguro T, Sobajima J, Fukuchi M, Ishibashi KI, Mochiki E, Aida J, Kawano T, Ishida H.
- Journal Title
  
  Endoscopy
  
  Volume: 49 Issue: 02 Pages: 176-180
- DOI
  10.1055/s-0042-119267
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] Endocytoscpic observation of various type esophagitis.2016
- Author(s)
  Kumagai Y, Takubo K, Kawada K, Higashi M, Ishiguro T, Sobajima J, Fukuchi M, Ishibashi K, Mochiki E, Aida J, Kawano T, Ishida H.
- Journal Title
  
  Esophagus
  
  Volume: 13 Issue: 2 Pages: 200-207
- DOI
  10.1007/s10388-015-0517-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] Tumor-associated macrophages and angiogenesis in early-stage esophageal squamous cell carcinoma.2016
- Author(s)
  Kumagai Y, Sobajima J, Higashi M, Ishiguro T, Fukuchi M, Ishibashi K, Mochiki E, Yakabi K, Kawano T, Tamaru J, Ishida H.
- Journal Title
  
  Esophagus
  
  Volume: 13 Issue: 3 Pages: 245-253
- DOI
  10.1007/s10388-015-0520-6
- NAID
  40020882764
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
- Author(s)
  Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: 印刷中 Issue: 10 Pages: 1-4
- DOI
  10.3109/10428194.2015.1016930
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] Endocytoscopic observation of various esophageal lesions at x600: can nuclear abnormality be recognized?2015
- Author(s)
  Kumagai Y, Kawada K, Higashi M, Ishiguro T, Sobajima J, Fukuchi M, Ishibashi K, Baba H, Mochiki E, Aida J, Kawano T, Ishida H, Takubo K.
- Journal Title
  
  Diseases Esophagus
  
  Volume: 印刷中 Issue: 3 Pages: 269-275
- DOI
  10.1111/dote.12183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.2015
- Author(s)
  Higashi M, Tokuhira M, Fujino S, Yamashita T, Abe K, Arai E, Kizaki M, Tamaru J.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 57 Issue: 1 Pages: 161-6
- DOI
  10.3109/10428194.2015.1038708
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08366
[Journal Article] Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma.2015
- Author(s)
  Kumagai Y, Sobajima J, Higashi M, Ishiguro T, Fukuchi M, Ishibashi K, Mochiki E, Yakabi K, Kawano T, Tamaru J, Ishida H.
- Journal Title
  
  International Surgery
  
  Volume: 100 Issue: 4 Pages: 733-43
- DOI
  10.9738/intsurg-d-14-00234.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] 【リンパ腫学-最新の研究動向-】リンパ腫研究の動向　Hodgkinリンパ腫　Hodgkinリンパ腫のNF-κBシグナル伝達系2015
- Author(s)
  東　守洋
- Journal Title
  
  日本臨床
  
  Volume: 73増刊8 Pages: 191-5
- Data Source
  KAKENHI-PROJECT-15K08366
[Journal Article] Angiogenesis in Superficial Esophageal Squamous Cell Carcinoma: Assessment of Microvessel Density Based on Immunostaining for CD34 and CD105.2014
- Author(s)
  Kumagai Y, Sobajima J, Higashi M, Ishiguro T, Fukuchi M, Ishibashi K, Baba H, Mochiki E, Yakabi K, Kawano T, Tamaru J, Ishida H.
- Journal Title
  
  Japanese Journal of Clinical Oncology.
  
  Volume: 44 Issue: 6 Pages: 526-33
- DOI
  10.1093/jjco/hyu039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461047
[Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014
- Author(s)
  Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H
- Journal Title
  
  Ann Hematol
  
  Volume: (印刷中) Issue: 7 Pages: 1111-1122
- DOI
  10.1007/s00277-014-2033-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380
[Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow.2014
- Author(s)
  Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H.
- Journal Title
  
  Ann Hematol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma.2014
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
- Journal Title
  
  Leuk Lymphoma
  
  Volume: (印刷中) Issue: 10 Pages: 2391-2394
- DOI
  10.3109/10428194.2014.880430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409
[Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
- Journal Title
  
  Br J Haematol
  
  Volume: 163(2) Issue: 2 Pages: 277-280
- DOI
  10.1111/bjh.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
[Journal Article] Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity.2012
- Author(s)
  Ito S, Ishii G, Hoshino A, Hashimoto H, Neri S, Kuwata T, Higashi M, Nagai K, Ochiai A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 442 Issue: 1 Pages: 194-9
- DOI
  10.1016/j.bbrc.2012.04.158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24659185
[Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL2012
- Author(s)
  Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 18(8) Pages: 2164-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL.2012
- Author(s)
  Kanemitsu N,
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 18（8） Issue: 8 Pages: 2164-2172
- DOI
  10.1158/1078-0432.ccr-11-2395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590338, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-23591407
[Journal Article] 【分子病態からみた血液疾患診療の進歩】ホジキンリンパ腫の病態解析の新展開2011
- Author(s)
  東守洋,田丸淳一
- Journal Title
  
  血液内科
  
  Volume: 62巻4号 Pages: 448-454
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011
- Author(s)
  Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, et. al.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 35(12) Pages: 1812-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] 【分子病態からみた血液疾患診療の進歩】ホジキンリンパ腫の病態解析の新展開2011
- Author(s)
  東　守洋, 田丸淳一
- Journal Title
  
  血液内科
  
  Volume: 62巻4号 Pages: 448-454
- Data Source
  KAKENHI-PROJECT-23590413
[Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011
- Author(s)
  Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, et. al
- Journal Title
  
  Am J Surg Pathol
  
  Volume: 35(12) Pages: 1812-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] MTX休薬後自然消退したEBV陽性粘膜皮膚潰瘍の5年後に、中枢のびまん性大細胞型B細胞リンパ腫を発症した一例2023
- Author(s)
  沢田圭佑, 百瀬修二, 山本渉, 今田浩生, 山下高久, 高橋匠, 多林孝之, 金子貴広, 東守洋, 田丸淳一
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K06966
[Presentation] びまん性大細胞型B細胞リンパ腫における高内皮細静脈の臨床病理学的意義2023
- Author(s)
  清水朋実(埼玉医科大学総合医療センター病理部), 石川雅浩, 山本渉, 菊地淳, 高柳奈津子, 阿南朋恵, 山下高久, 木崎昌弘, 小林直樹, 田丸淳一, 百瀬修二, 東守洋
- Organizer
  第63回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-22K06966
[Presentation] びまん性大細胞型B細胞リンパ腫における18q21領域の異常とTCF4発現の意義2023
- Author(s)
  今田浩生, 百瀬修二, 高柳奈津子, 沢田圭佑, 山下高久, 多林孝之, 木崎昌弘, 東守洋, 田丸淳一
- Organizer
  第63回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-22K06966
[Presentation] CD24はアグレッシブB細胞リンパ腫において"immune-cold"な腫瘍微小環境のsurrogate markerである2022
- Author(s)
  東守洋, 百瀬修二, 高柳奈津子, 田中佑加, 阿南朋恵, 山下高久, 菊地淳, 得平道英, 木崎昌弘, 田丸淳一
- Organizer
  第62回日本リンパ網内系学会
- Data Source
  KAKENHI-PROJECT-22K06966
[Presentation] DLBCLにおけるCD24分子発現の役割2021
- Author(s)
  東　守洋
- Organizer
  110回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K07467
[Presentation] 脳のlymphomatoid granulomatosisを機に診断された慢性リンパ球性白血病(CLL/SLL)の一例2021
- Author(s)
  村上千明(, 百瀬修二, 清水朋実, 今田浩生, 増田渉, 中村翔, 大宅宗一, 東守洋, 田丸淳一
- Organizer
  110回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K07467
[Presentation] DLBCLにおけるCD24分子発現の役割2021
- Author(s)
  東　守洋, 高柳奈津子, 田中佑加, 阿南朋恵, 山下高久, 得平道英, 百瀬修二, 木崎昌弘, 田丸淳一
- Organizer
  110回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K07467
[Presentation] MYC-associated factor X(MAX)発現量の低下は未分化大細胞リンパ腫の予後不良に関する新規の有望なバイオマーカーである2020
- Author(s)
  山下高久, 東守洋, 清水朋美, 沢田圭佑, 伊藤梢絵, 山崎真美, 高柳奈津子, 菊地淳, 今田浩生, 川野竜太郎, 増田渉, 百瀬修二, 田中佑加, 得平道英, 木崎昌弘, 田丸淳一
- Organizer
  第60回日本リンパ網内系学会
- Data Source
  KAKENHI-PROJECT-19K07467
[Presentation] Tumor-associated macrophages and angiogenesis in early-stage esophageal squamous cell carcinoma.2016
- Author(s)
  Sobajima J,Kumagai Y,Higashi M,Ishiguro T,Fukuchi M,Ishibashi k,Mochiki E,Amano K,Hatano S,Ishida H．
- Organizer
  40th World Congress of the International College of Surgeons
- Place of Presentation
  Kyoto
- Year and Date
  2016-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461047
[Presentation] 食道癌発癌早期におけるリンパ管新生とVEGF-C,Dとの関係．2016
- Author(s)
  天野邦彦，熊谷洋一，傍島潤，幡野哲，福地稔，石畝亨，石橋敬一郎，東守洋，持木彫人，石田秀行．
- Organizer
  第68回日本気管食道科学会
- Place of Presentation
  東京
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-26461047
[Presentation] 腫瘍関連マクロファージ（TAM）と食道癌発癌早期の血管新生の関連．2016
- Author(s)
  傍島潤，熊谷洋一，石畝亨，天野邦彦，幡野哲，福地稔，石橋敬一郎，東守洋,持木彫人，石田秀行．
- Organizer
  第68回日本気管食道科学会
- Place of Presentation
  東京
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-26461047
[Presentation] LR11はCD20とタンパク複合体を形成しRituximabの補体依存性細胞傷害を抑制する2015
- Author(s)
  東守洋, 得平道英, 中世古知昭, 木崎昌弘, 武城英明, 田丸淳一
- Organizer
  第55回日本リンパ網内系学会総会
- Place of Presentation
  岡山
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K08366
[Presentation] LR11: implications for molecular targeting therapy in lymphoma2013
- Author(s)
  Morihiro Higashi, Michihide Tokuhira, Takeharu Kawaguchi, Masahiro Takeuchi, Chikako Ohwada, Chiaki Nakaseko, Toshiki Watanabe, Hideaki Bujo, Masahiro Kizaki, Jun-ichi Tmaru
- Organizer
  2nd Joint Scientific Meeting Medical University of Vienna and Chiba University
- Place of Presentation
  ウィーン,オーストリア
- Year and Date
  2013-02-15
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] 悪性リンパ腫におけるLR11発現と意義2012
- Author(s)
  東守洋, 得平道英, 川口岳晴, 竹内正博, 大和田千佳子, 中世古知明, 武成英明, 木崎昌弘, 田丸淳一
- Organizer
  悪性リンパ腫治療研究会
- Place of Presentation
  京都
- Year and Date
  2012-03-03
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] Expression of LR11 in malignant lymphoma2011
- Author(s)
  東守洋, 得平道英, 川口岳晴, 竹内正博, 大和田千佳子, 中世古知明, 武成英明, 木崎昌弘, 田丸淳一
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] LR11 Expression in Malignant Lymphoma
- Author(s)
  Morihiro Higashi, Michihide Tokuhira, Takeharu Kawaguchi, Masahiro Takeuchi, Chikako Ohwada, Chiaki Nakaseko, Toshiki Watanabe, Hideaki Bujo, Masahiro Kizaki, Jun-ichi Tmaru.
- Organizer
  The 3rd JSH International Symposium 2012 in Kawagoe
- Place of Presentation
  Prince Hotel Kawagoe, Kawagoe, Saitama
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] Endocytoscopic observation (GIF-Y0002) of various esophageal lesions at X600.
- Author(s)
  Kumagai Y,Kawada K,Ishiguro T,Sobajima J,Higashi M,Fukuchi M,Ishibashi K,Baba H,Mochiki E,Aida J,Kawano T,Ishida H.
- Organizer
  14th World Congress of the International Society for Diseases of the Esophagus
- Place of Presentation
  Bancouver, Canada
- Year and Date
  2014-09-23 – 2014-09-24
- Data Source
  KAKENHI-PROJECT-26461047
[Presentation] Microvessel density in superficial esophageal squamous cell carcinoma using anti-CD34 and anti-CD105 antibody.
- Author(s)
  Kumagai Y,Sobajima J,Higashi M,Ishiguro T,Fukuchi M,Ishibashi K,Baba H,Mochiki E,Kawano T,Ishida H.
- Organizer
  14th World Congress of the International Society for Diseases of the Esophagus
- Place of Presentation
  Bancouver, Canada
- Year and Date
  2014-09-22 – 2014-09-24
- Data Source
  KAKENHI-PROJECT-26461047
[Presentation] 悪性リンパ腫におけるLR11発現とその意義
- Author(s)
  東守洋, 得平道英, 川口岳晴, 武内正博, 大和田千佳子, 中世古知昭, 渡邊俊樹, 武城英明, 木崎昌弘, 田丸淳一
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京、新宿、京王プラザホテル
- Data Source
  KAKENHI-PROJECT-23590413
[Presentation] LR11 repressed Rituximab Cytotoxity in B-cell lymphoma.
- Author(s)
  東守洋、得平道英、川口岳晴、武内正博、大和田千佳子、中世古知明、武城英明、木崎昌弘、田丸淳一
- Organizer
  第75回日本血液学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590413

1. TAMARU Jun-ichi (30188429)

# of Collaborated Projects: 4 results

# of Collaborated Products: 30 results
2. HARIGAYA Kenichi (40101894)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KITAGAWA Motoo (40262026)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KAWANA Hidetada (80359596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Kumagai Youichi (80611087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. KAWADA Kenro (20311219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. TAKUBO Kaiyo (00154956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. KAWANO Tatsuyuki (00186115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. ISHIDA Hideyuki (00262197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
10. ISHIGURO Toru (10383241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
11. SOBAJIMA Jun (40406517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. JIANG Meizi (00624066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. BUJO Hideaki (80291300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIMIZU Naomi (30375802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 岸宏久 (90323394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 石井源一郎 (00270869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 百瀬修二 (70360344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
18. Antonio Vidal-Puig

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 横手幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHI MORIHIRO 東 守洋

Higashi Morihiro 東 守洋

HIGASHI Morihiro 東 守洋

東 守洋 ヒガシ モリヒロ

Research Projects

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Co-Researchers

濾胞性リンパ腫における濾胞樹状細胞による免疫逃避機構Principal Investigator

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Mechanism of DLBCL tumor immune microenvironment modification initiated by CD24.Principal Investigator

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Molecular function of LR11 in lipid metabolism of malignant lymphomaPrincipal Investigator

Principal Investigator

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リツキシマブ細胞傷害におけるLR11の分子機構の解明Principal Investigator

Principal Investigator

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Im vivo observation using the endocytoscopy system (GIF-Y0002) for the esophageal lesions

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Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetes

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The role of Mastermind in B-cell lymphomaPrincipal Investigator

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新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析

Principal Investigator

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Molecular cloning and function of CD44 cytoplasmic domain associated molecules

Principal Investigator

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CD44の細胞運動・転移関連遺伝子発現における役割

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[Book] 造血器腫瘍とエピジェネティクス -治療への応用と新たな展開-2012

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[Journal Article] DLBCLにおけるCD24発現の意義 治療標的としての微小環境2023

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[Journal Article] Anti-neutrophil cytoplasmic antibody-negative granulomatosis with polyangiitis manifesting through pulmonary nodules and a genital lesion2023

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DOI

HIGASHI MORIHIRO 東守洋

Higashi Morihiro 東守洋

HIGASHI Morihiro 東守洋

東守洋ヒガシモリヒロ

[Journal Article] DLBCLにおけるCD24発現の意義　治療標的としての微小環境2023