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Tanigichi Yoshihito  谷口 善仁

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TANIGUCHI Yoshihito  谷口 善仁

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Researcher Number 00324616
Affiliation (based on the past Project Information) *help 2014 – 2017: 杏林大学, 医学部, 教授
2010: 慶應義塾大学, 医学部, 講師
2009: 京都大学, 大学院・医学研究科, 准教授
2008 – 2009: Kyoto University, 医学研究科, 准教授
2007: Kyoto University, 医学研究科, 助教
2004 – 2006: 京都大学, 医学研究科, 助手
2000: Kyoto Univ., Grad.Sch.Med., Assistant Prof., 医学研究科, 助手
Review Section/Research Field
Principal Investigator
General medical chemistry / Laboratory animal science / Pathological medical chemistry
Except Principal Investigator
Laboratory animal science / Risk sciences of radiation/Chemicals / Immunology / Biological Sciences
Keywords
Principal Investigator
メダカ / TILLING / ENU / medaka / p53 / Chkl / knockout / チェックポイント / 発生・分化 / 遺伝子 … More / P53 / Chk1 / ノックアウト / CYP1A1 / dioxin / cyp1a / メタボローム / 変異体 / AhR / ダイオキシン / 多環芳香族炭化水素 / P450 / CYP1A / トランスポゾン / 遺伝学 / ゲノム / 疾患モデル / 遺伝子破壊 / 次世代シーケンサー / ゼブラフィッシュ / トランスポザーゼ / 変異 / 放射線 / 腫瘍 / 温度感受性変異 / ブルーム症候群 / 減数分裂 / 抗体 / 温度感受性 … More
Except Principal Investigator
Stat / メダカ / 放射線 / NASH / 動物モデル / NASHモデル / Revl / TLS DNA polvmerase / Medaka / Mutagenesis / Reverse Genetics / 紫外線 / 環境変動 / 逆遺伝学(Reverse Genetics) / 環境変異原 / 逆遺伝学 / TILLING / 突然変異体 / retrovirus / transcriptional coactivator / histone acetylation / DNA recombination / signal transduction / γδT cell / cytokine receptor / レトロウィルス / STAT / レトロウイルス / 転写共役因子 / ヒストンアセチル化 / DNA組換え / シグナル伝達 / γδT細胞 / サイトカインレセプター / 相同組み換え / トポイソメラーゼ阻害薬 / 放射線治療 / p53 / DT40 / シスプラチン / ゲノム不安定性 / 変異 / DNA修復 / DNA組み換え / バイオテクノロジー / 細胞・組織 / ゲノム / 癌 Less
  • Research Projects

    (8 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (15 People)
  •  Search for AhR endogenous ligands by metabolomicsPrincipal Investigator

    • Principal Investigator
      Taniguchi Yoshihito
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Kyorin University
  •  Development of a novel animal model of hepatocellular carcinoma with nonalcoholic steatohepatitis

    • Principal Investigator
      Aiura Koichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Keio University
  •  実験用魚類の遺伝子破壊低コスト化のための変異濃縮技術の開発Principal Investigator

    • Principal Investigator
      谷口 善仁
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Keio University
      Kyoto University
  •  The impact of thermodynamically unstable p53 protein on organismPrincipal Investigator

    • Principal Investigator
      TANIGUCHI Yoshihito
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  Reverse Genetic Analysis of DNA Damage responses in the Avian DT40 Cell Line and the Medaka Fish

    • Principal Investigator
      TAKEDA Shunichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Analysis of function of Chk1 kinase using medakafishPrincipal Investigator

    • Principal Investigator
      TANIGUCHI Yoshihito
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Kyoto University
  •  Establishment of Reverse Genetics in Medaka : Screening for Induced Point Mutations in Medaka with TILLING

    • Principal Investigator
      TODO Takeshi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyoto University
  •  Induction mechanism of V-J recombination by signaling molecules of the IL-7 receptor

    • Principal Investigator
      IKUTA Koichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY

All 2017 2016 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

  • [Book] Medaka Book (Medaka : A Model for Organogenesis, Human Disease and Evolution)2011

    • Author(s)
      Yoshihito Taniguchi
    • Publisher
      Springer(in press)
    • Data Source
      KAKENHI-PROJECT-21650098
  • [Journal Article] Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging.2017

    • Author(s)
      Yip BW, Mok HO, Peterson DR, Wan MT, Taniguchi Y, Ge W, Au DW.
    • Journal Title

      Mar Pollut Bull.

      Volume: 印刷中 Issue: 2 Pages: 701-709

    • DOI

      10.1016/j.marpolbul.2017.01.021

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460377
  • [Journal Article] A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect2010

    • Author(s)
      Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
    • Journal Title

      Environ Health Perspect. VOL.117

      Pages: 1737-1744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] approach using DNA-repair-deficient (2010) A novel chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants.2010

    • Author(s)
      Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
    • Journal Title

      Environ Health Perspect. 117

      Pages: 1737-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Collaborative action of Brcal and CtIP in elimination of covalent modifi cations from double-strand breaks to facilitate subsequent break repair.2010

    • Author(s)
      Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y.
    • Journal Title

      PLoS Genet. VOL.6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Bloom DNA helicase facilitates Hirota K. (2009) homologous recombination between diverged homologous sequences.2009

    • Author(s)
      Kikuchi K, Abdel-Aziz HI, Yamazoe M, Taniguchi Y, Takeda S
    • Journal Title

      J B i o l C h e m. 284

      Pages: 26360-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.2009

    • Author(s)
      Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K.
    • Journal Title

      J Biol Chem. VOL.284

      Pages: 26360-26367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] 魚類を利用した創薬2009

    • Author(s)
      谷口善仁, 武田俊一
    • Journal Title

      実験医学(増刊) 142

      Pages: 805-810

    • Data Source
      KAKENHI-PROJECT-19590305
  • [Journal Article] for single-strand lesions initiating (2009) Genetic evidence Nbs1-dependent homologous recombination in diversification of Ig V in chicken B lymphocytes.2009

    • Author(s)
      Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Nakamura K, Sumitomo Y, Bree RT, Lowndes Taniguchi Y, NF, Takeda S.
    • Journal Title

      P L o S G e n e t. 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] 魚類を利用した創薬2009

    • Author(s)
      谷口善仁、武田俊一
    • Journal Title

      実験医学 27

      Pages: 805-810

    • Data Source
      KAKENHI-PROJECT-19590305
  • [Journal Article] Genetic evidence for single-strand lesions initiating Nbs1-dependent homologousrecombination in diversification of Ig V in chicken B lymphocytes2009

    • Author(s)
      Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S
    • Journal Title

      PLoS Genet 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion2008

    • Author(s)
      Oka H. Sakai if, Sonoda E, Nakamura J, Asagoshi K, Wilson Si, Kobayashi N, Yamamoto K. Heierhorst J, Takeda S. Taniguchi Y
    • Journal Title

      Biochem Biophys Rei Commun 371

      Pages: 225-229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.2008

    • Author(s)
      Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y.
    • Journal Title

      B i o c h e m B i o p h y s R e s C o m m u n. 371

      Pages: 225-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] RAD18and poly[ADPribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007

    • Author(s)
      Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Y, Hua W, Yokomori K, Helleday T, Teraoka Murakawa H, Arakawa H, Buerstedde JM, Takeda S.
    • Journal Title

      M o l C e l l B i o l. 27

      Pages: 2562-2571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] RAD18 and poly [ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007

    • Author(s)
      Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Atakawa H, Buerstedde JM, Takeds S
    • Journal Title

      Mol Cell Biol. 27

      Pages: 2562-2571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. (Review)2007

    • Author(s)
      Takeda S, Nakamura K, Taniguchi Y, Paull TT
    • Journal Title

      Mol Cell 28

      Pages: 351-352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks.2006

    • Author(s)
      akamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y.
    • Journal Title

      D N A R e p a i r ( A m s t ) 5

      Pages: 741-749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] end-joining and homologous Differential usage of non-homologous recombination in double strand break repair.2006

    • Author(s)
      Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S.
    • Journal Title

      D N A R e p a i r ( A m s t ) 5(Review)

      Pages: 1021-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.2006

    • Author(s)
      Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S
    • Journal Title

      DNA Repair (Amst) 5

      Pages: 1021-1029

    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis2006

    • Author(s)
      Taniguchi Y, Todo T, et al.
    • Journal Title

      Genome Biol 7(12)

    • Data Source
      KAKENHI-PROJECT-16201011
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E
    • Journal Title

      Genome Biology 7(12)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590248
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis2006

    • Author(s)
      Taniguchi Y
    • Journal Title

      Genome Biol. 7

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16201011
  • [Journal Article] Genetic dissection of vertebrate 53BP1 : a major role in non-homologous end joining of DNA double strand breaks.2006

    • Author(s)
      Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y
    • Journal Title

      DNA Repair (Amst) 5

      Pages: 741-749

    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Takeda S, Furutani-Seikl M, Kamel Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.
    • Journal Title

      Genome Biol. 7

    • Data Source
      KAKENHI-PROJECT-17590248
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.
    • Journal Title

      Genome Biology 7 (12)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590248
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Takeda S, M, Kamei Y, Todo T, Sasado T, Deguchi T, Furutani-Seiki Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.
    • Journal Title

      G e n o m e B i o l. 7(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Furutani-Seiki M, Kamei Y, Todo T, Mitani H, et. al.
    • Journal Title

      Genome Bid. 7(12)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16201011
  • [Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006

    • Author(s)
      Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y., Plasterk RH., Cuppen E
    • Journal Title

      Genome Biol 7

    • Data Source
      KAKENHI-PROJECT-17013039
  • [Journal Article] RAD18 and poly[ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.

    • Author(s)
      Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S
    • Journal Title

      Mol Cell (in press)

    • Data Source
      KAKENHI-PROJECT-17013039
  • [Presentation] CYP1A欠損が生体内代謝産物に与える変動2016

    • Author(s)
      谷口善仁
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-26460377
  • [Presentation] Gene disruption of medaka and creation of human disease model by TILLING2010

    • Author(s)
      Yoshihito Taniguchi
    • Organizer
      5th Aquatic Animal Model for Human Disease
    • Place of Presentation
      アメリカ・オレゴン州
    • Year and Date
      2010-09-20
    • Data Source
      KAKENHI-PROJECT-21650098
  • [Presentation] 小型魚類を用いたがん研究2009

    • Author(s)
      谷口善仁
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21650098
  • [Presentation] メダカ精母細胞の減数分裂を制御する相同組換関連因子BLMヘリカーゼ2009

    • Author(s)
      谷口善仁、岩井俊治、山下正兼、武田俊一
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-19590305
  • [Presentation] TILLING法による遺伝子破壊メダカ作製の現状2009

    • Author(s)
      谷口善仁
    • Organizer
      第80回日本動物学会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21650098
  • [Presentation] BRCA1-CTIP complex plays a novel role in cellular tolerance to double-strand breaks associated with polypeptides in the presence of topoisomerase poisons.2008

    • Author(s)
      Takeda S, Nakamura K, Taniguchi Y
    • Organizer
      Abcam, Maintenance of Genome Stability Conference 2008
    • Place of Presentation
      Puerto Vallarta, Mexico
    • Data Source
      KAKENHI-PROJECT-17013039
  • [Presentation] Inactivation of Medaka Genes by Target-Selected Mutagenesis.2008

    • Author(s)
      谷口善仁、豊田敦、榊佳之、武田俊一
    • Organizer
      The 54th NIBB Conference
    • Place of Presentation
      自然科学研究機構 基礎生物学研究所
    • Year and Date
      2008-02-29
    • Data Source
      KAKENHI-PROJECT-19590305
  • [Presentation] メダカ精母細胞の減数分裂を制御する相同組換関連因子BLMヘリガーゼ2008

    • Author(s)
      谷口善仁, 岩井俊治, 山下正兼, 武田俊一
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19590305
  • 1.  KAMEI Yasuhiro (70372563)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  TAKEDA Shunichi (60188191)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 3.  IKUTA Koichi (90193177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KUROOKA Hisanori (00293879)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KINOSHITA Kazuo (50293874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TODO Takeshi (90163948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  MITANI Hiroshi (70181922)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  SEIKI Makoto (50226619)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  Aiura Koichi (00184010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Itano Osamu (90265827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Kitago Minoru (70296599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Matsuda Sachiko (90534537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Onishi Akira (30414890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Kojima Misaki (80355742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Yoshiura Yasushi (90372052)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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