Shimazaki Takuya 島崎琢也

… Alternative Names

SHIMAZAKI Takuya 島崎琢也

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Researcher Number	00324749
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 慶應義塾大学, 医学部(信濃町), 准教授 2014 – 2015: 慶應義塾大学, 医学部, 准教授 2010 – 2013: 慶應義塾大学, 医学部, 講師 2007 – 2008: Keio University, 医学部, 講師 2001 – 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience / Neuroscience in general / Neurochemistry/Neuropharmacology / Neuroscience in general / Biological Sciences Except Principal Investigator Neuroscience in general / Biological Sciences
Keywords	Principal Investigator 神経幹細胞 / ES細胞 / 分化 / グリア / 神経前駆細胞 / 時系列特異的 / 転写制御因子 / Coup-TFI/II / 転写因子 / 神経細胞 … More / 増殖 / 神経分化 / p38 MAP-Kinase / 成体神経幹細胞 / 成体脳 / 老化 / p38 / 神経新生 / マーカー / Retinoic Acid / Dopaminergic neuron / GABAergic neuron / Motoneuron / Cholinergic neuron / Stem cell / Neural progenitor cell / ES cells / GABAニューロン / noggin / HB9 / Embryoid Body(EB) / Phox2B / Embryoid Body (EB) / 霊長類 / neurosphere / 遺伝子発現プロファイリング / DNAマイクロアレイ / レチノイン酸 / ドーパミンニューロン / GABA作動性ニューロン / 運動ニューロン / コリン作動性ニューロン / 幹細胞 / 神経系前駆細 / 再生 / lncRNA / 初期化 / 神経 / NFIA / p38MAP-kinase / miRNA / クローニング / ES 細胞 / 生存因子 / PA-6 / アストロサイト / olig2 / 自己維持 / GFAP / Galectin-1 / gp130 / オリゴデンドロサイト前駆細胞 / PI3-kinase / MAP kinase / EGFレセプター / 脊髄 / EGF / Olig2 / Akt / PI3-Kinase / Gab1 / 生存 / 培養上清 / PA6細胞 … More Except Principal Investigator GFP / Nestin / 神経幹細胞 / Cell Sorter / Marrow Stromal Cells / CNS Regeneration / Neural Stem Cells / nestin / セルソーター / 骨髄間質細胞 / 神経再生 / 神経結合 / 大脳皮質領野 / 層構造 / 領野形成 / 層形成 / 多様性 / 神経細胞 / 神経科学 / 神経細胞多様性 / 時系列制御 / 大脳皮質 / 神経投射 / 層 / 領野 / 大脳新皮質 Less

Transcription factors regulating temporal specification of neuronal subtypes.Principal Investigator
- Principal Investigator
  
  島崎琢也
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Regulatory mechanisms of aging of adult neural stem/progenitor cells via p38 MAPKPrincipal Investigator
- Principal Investigator
  
  SHIMAZAKI Takuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Keio University
Mechanisms of glial developmentPrincipal Investigator
- Principal Investigator
  
  Shimazaki Takuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Keio University
Generation of Neural Diversity and Neocortex
- Principal Investigator
  
  Yamamori Tetsuo
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
  National Institute for Basic Biology
Mechanisms of neurogenesis and gliogenesis by neural stem cellsPrincipal Investigator
- Principal Investigator
  
  SHIMAZAKI Takuya
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Rejuvenation of neural stem cellsPrincipal Investigator
- Principal Investigator
  
  SHIMAZAKI Takuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Keio University
Identification of neural stem cell survival factorPrincipal Investigator
- Principal Investigator
  
  SHIMAZAKI Takuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Keio University
神経幹細胞の未分化性維持機構の解析Principal Investigator
- Principal Investigator
  
  島崎琢也
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Bone Marrow Autograft for CNS Regeneration by Neural Stem Cells
- Principal Investigator
  
  NAMIKI Jun
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  KEIO UNIVERSITY
Mechanisms of Development and Regeneration of Mammalian Central Nervous SystemPrincipal Investigator
- Principal Investigator
  
  SHIMAZAKI Takuya
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Keio University

All 2020 2019 2016 2015 2014 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation

[Journal Article] Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?2020
- Author(s)
  Yoshitaka Kase, Takuya Shimazaki, Hideyuki Okano
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 40 Issue: 1
- DOI
  10.1186/s41232-020-00122-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04787
[Journal Article] Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.2019
- Author(s)
  Kase Y, Otsu K, Shimazaki T, Okano H.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 12 Issue: 6 Pages: 1313-1328
- DOI
  10.1016/j.stemcr.2019.04.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06469, KAKENHI-PUBLICLY-19H04787
[Journal Article] Vertebrate Neural Stem Cells: Development, Plasticity, and Regeneration.2016
- Author(s)
  Shimazaki T*
- Journal Title
  
  The Keio Journal of Medicine
  
  Volume: 65 Issue: 1 Pages: 1-15
- DOI
  10.2302/kjm.2015-0005-ir
- NAID
  130005138573
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06719
[Journal Article] Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation2016
- Author(s)
  Shimazaki T*, Okano H*
- Journal Title
  
  npj Aging and Mechanisms of Disease
  
  Volume: 2 Issue: 1 Pages: 15014-15014
- DOI
  10.1038/npjamd.2015.14
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06719
[Journal Article] MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells.2015
- Author(s)
  Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T*, Okano H*
- Journal Title
  
  Stem Cell Reports
  
  Volume: 5 Issue: 3 Pages: 365-377
- DOI
  10.1016/j.stemcr.2015.06.006
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06719, KAKENHI-PROJECT-25220205
[Journal Article] LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop.2014
- Author(s)
  Tomioka T, Shimazaki T, Yamauchi T, Oki T, Ohgoh M, Okano H
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 2 Pages: 1000-1010
- DOI
  10.1074/jbc.m113.494385
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22123004
[Journal Article] The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells2014
- Author(s)
  Hayato Naka-Kanedaa, Shiho Nakamuraa, Mana Igarashi, Hisashi Aoid, Hiroaki K ankib, Jun Tsuyama, Shuichi Tsutsumie, Hiroyuki Aburatanie, Takuya Shimazakib, and Hideyuki Okano.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 111(4) Issue: 4 Pages: 1604-1609
- DOI
  10.1073/pnas.1315567111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J07264, KAKENHI-PLANNED-22123004, KAKENHI-PROJECT-24689017, KAKENHI-PUBLICLY-25118709
[Journal Article] FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.2010
- Author(s)
  Sato, T., Shimazaki T, Naka, H., Fukami, S., Satoh, Y., Okano, H., Lax, I., Schlessinger, J., & Gotoh, N.
- Journal Title
  
  Stem Cells.
  
  Volume: 28 Pages: 1661-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500339
[Journal Article] Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction2010
- Author(s)
  Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki T, Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K., & Okano, H.
- Journal Title
  
  J. Neurochem.
  
  Volume: 113 Pages: 1516-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500339
[Journal Article] Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders : properties and tumorigenicity after long-term in vitro maintenance2009
- Author(s)
  Ogawa D, Okada Y, Nakamura M, Kanemura Y, Okano HJ, Matsuzaki Y, Shimazaki T, Ito M, Ikeda E, Tamiya T, Nagao S, Okano H
- Journal Title
  
  J Neuroci Res 87
  
  Pages: 307-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Requirement for COUP-TFI and II in the temporal specification of neural stem cells in central nervous system development2008
- Author(s)
  Naka H, Nakamura S, Shimazaki T, Okano H
- Journal Title
  
  Nature Neurosci 11
  
  Pages: 1014-1023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Spatio-temporal recapitulation of central nervous system development by ES cell-derived neural stem/progenitor cells2008
- Author(s)
  Okada Y, Matsumoto A, Shimazaki T, Enoki R, Koizumi A, Ishii S, Itoyama Y, Sobue G, Okano H
- Journal Title
  
  Stem Cells 26
  
  Pages: 3086-3098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord2007
- Author(s)
  Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H
- Journal Title
  
  Stem Cells 25
  
  Pages: 1410-1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Yneurons in the arcuate nucleus via phosphatidylinositol 3-kinase-and phosphodiesterase 3-mediated pathway2007
- Author(s)
  Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T.
- Journal Title
  
  Endocrinology 148
  
  Pages: 2251-2263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.2007
- Author(s)
  Ozawa Y., Nakao K., Shimazaki T., Shinmura S., Kurihara T., Ishida S., Yoshimura A., Tsubota K., Okano H
- Journal Title
  
  Developmental Biology 303
  
  Pages: 591-600
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucle us via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.2007
- Author(s)
  Kohno D, Nakata M, Maekawa F, Fujiw ara K, Maejima Y, Kuramochi M, Shimazaki T, Onaka T, Yada T.
- Journal Title
  
  Endocrinology 148
  
  Pages: 2251-2263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Simian fetal brain progenitor cells for studying viral neuropathogenesis2007
- Author(s)
  Iwata N, Yoshida H, Tobiume M, Ono F, Shimazaki T, Sata T, Nakajima N
- Journal Title
  
  J Neurovirol 13
  
  Pages: 11-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Epidermal growth factor signaling mediated by grb2 associated binderl is required for the spatiotemporally rcgulated proliferration of olig2-expressing progenitors in the emblyonic spinal cord2007
- Author(s)
  Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H.
- Journal Title
  
  Stem Cells 25
  
  Pages: 1410-1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Simian fetal brain progenitor cells for studying viral neuropathogenesis2007
- Author(s)
  Iwata N, Yoshida H, Tobiume M, Ono F, Shimazaki T, Sata T, Nakajima N.
- Journal Title
  
  J Neurovirol 13
  
  Pages: 11-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500274
[Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.2007
- Author(s)
  Kohno D., Nakata M., Maekawa F., Fujiwara K., Maejima Y., Kuramochi M., Shimazaki T, Okano H., Onaka T., Yada T
- Journal Title
  
  Endocrinology (In press)
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] EGF-signaling mediated by Gabl is required for the spatiotemporally regulated proliferation of Olig2-expressing progenitors in the embryonic spinal cord2007
- Author(s)
  Hayakawa-Yano Y., Nishida K., Fukami S., Gotoh Y., Hirano T., Nakagawa T., Shimazaki T, Okano H
- Journal Title
  
  Stem Cells (In press)
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Histopathological and behavioral improvement of murine Mucopolysaccharidosis type VII by intra-cerebral transplantation of neural stem cells.2006
- Author(s)
  Fukuhara Y, Li X-K, Kitazawa Y, Inagaki M, Matsuoka K, Kosuga M, Kosaki R, Shimazaki T, et al.
- Journal Title
  
  Molecular Therapy 13
  
  Pages: 548-555
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.2006
- Author(s)
  Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H
- Journal Title
  
  Nature Medicine 12
  
  Pages: 829-834
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.2006
- Author(s)
  Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 103
  
  Pages: 7112-7117
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers.2005
- Author(s)
  Nagato M, Heike T, Kato T, Yamanaka Y, Yoshimoto M, Shimazaki T, Okano H, Nakahata T.
- Journal Title
  
  J Neurosci Res 80
  
  Pages: 456-466
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression.2005
- Author(s)
  Uemura O, Okada Y, Ando H, Guedj M, Higashijima S, Shimazaki T, Chino N, Okano H, Okamoto H.
- Journal Title
  
  Dev Biol 278
  
  Pages: 587-606
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Inhibition of glioma cell proliferation by neural stem cell factor.2005
- Author(s)
  Suzuki T, Izumoto S, Wada K, Fujimoto Y, Maruno M, Yamasaki M, Kanemura Y, Shimazaki T, Okano H, Yoshimine T.
- Journal Title
  
  J.Neurooncol. 74
  
  Pages: 233-239
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers.2005
- Author(s)
  Nagato M, Heike T, Kato T, Yamanaka Y, Yoshimoto M, Shimazaki T, Okano H, Nakahata T
- Journal Title
  
  J Neurosci Res (In Press)
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Comparative functional genomics revealed conservation and diversification of three enhancers of the isll gene for motor and sensory neuron-specific expression.2005
- Author(s)
  Uemura O, Okada Y, Ando H, Guedj M, Higashijima S, Shimazaki T, Chino N, Okano H, Okamoto H.
- Journal Title
  
  Dev Biol 278
  
  Pages: 587-606
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers.2005
- Author(s)
  Nagato M, Heike T, Kato T, Yamanaka Y, Yoshimoto M, Shimazaki T, Okano H, Nakahata T.
- Journal Title
  
  J.Neurosci.Res. 80
  
  Pages: 456-466
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] A method for gene transfer, single isolation and in vitro assay for neural stem cells.2005
- Author(s)
  Sakaguchi M, Sawamoto K, Shimazaki T, Kitamura T, Shibuya A, Okano H
- Journal Title
  
  Inflammation and Regeneration 25
  
  Pages: 50-54
- NAID
  10026498954
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart.2005
- Author(s)
  Tomita Y, Matsumura K, Wakamatsu Y, Matsuzaki Y, Shibuya I, Kawaguchi H, Ieda M, Kanakubo S, Shimazaki T. et al.
- Journal Title
  
  J.Cell Biol. 170
  
  Pages: 1135-1146
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers.2005
- Author(s)
  Nagato M, Heike T, Kato T, Yamanaka Y, Yoshimoto M, Shimazaki T, Okano H, Nakahata T.
- Journal Title
  
  J Neurosci Res (In Press)
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Essential role of Shp2-binding sites on the docking protein FRS2α for mammalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells.2005
- Author(s)
  Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 15983-15988
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] A method for gene transfer, single isolation and in vitro assay for neural stem cells.2005
- Author(s)
  Sakaguchi M, Sawamoto K, Shimazaki T, Kitamura T, Shibuya A, Okano H
- Journal Title
  
  Inflammation and Regeneration 25
  
  Pages: 50-54
- NAID
  10026498954
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells.2005
- Author(s)
  Yuasa S, Itabashi Y, Koshimizu U, Tanaka T, Sugimura K, Fukami S, Itabashi Y, Hattori F, Shimazaki T, Ogawa S, Okano H, Fukuda K.
- Journal Title
  
  Nature Biotech. 23
  
  Pages: 607-611
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells2004
- Author(s)
  Shimazaki T, Shingo T, Weiss S.
- Journal Title
  
  J Neurosci 21
  
  Pages: 7642-7653
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells.2004
- Author(s)
  Okada Y, Shimazaki T, Sobue G, Okano H.
- Journal Title
  
  Dev Biol 275
  
  Pages: 124-142
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Isolation and transplantation of dopaminergic neurons and neural stem cells.2004
- Author(s)
  Okano, H., Yoshizaki, T., Shimazaki.T, Sawamoto, K
- Journal Title
  
  Parkinsonism Relat Disord 26
  
  Pages: 258-270
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Human neuronal stem cells improve sensorimotor and cognitive impairment in Mongolian gerbils after ischemia.2004
- Author(s)
  Ishibashi S, Sakaguchi M, Kuroiwa T, Shimazaki T, Okano H, Mizusawa H.
- Journal Title
  
  J Neurosci.Res 78
  
  Pages: 215-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Implantation of dendritic cells in the injured adult spinal coed results in activation of the endogenous neural/progenitor cells for den novo neurogenesis and axonal regeneration, leading to functional recovery.2004
- Author(s)
  Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M.
- Journal Title
  
  J Neurosci Res 76
  
  Pages: 453-465
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.2004
- Author(s)
  shibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Shizuko I, Shimazaki T, Onodera M, Okano H, Mizusawa H.
- Journal Title
  
  J Neurosci Res 78
  
  Pages: 215-223
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.2004
- Author(s)
  Yoshizaki T, Inaji M, Kouike H, Shimazaki T, Sawamoto K, Ando K, Date I, Kobayashi K, Suhara T, Uchiyama Y, Okano H
- Journal Title
  
  Neurosci Lett 363
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells.2004
- Author(s)
  Okada Y, Shimazaki T, Sobueb G, Okano H.
- Journal Title
  
  Dev Biol 275
  
  Pages: 124-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Meteorin : a secreted protein that regulates glial cell differentiation and promotes axonal extension.2004
- Author(s)
  Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H.
- Journal Title
  
  EMBO J 23
  
  Pages: 1998-2008
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.2004
- Author(s)
  Ishibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Shizuko I, Shimazaki T, Onodera M, Okano H, Mizusawa H.
- Journal Title
  
  J Neurosci Res 78
  
  Pages: 215-223
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression.2004
- Author(s)
  Uemura O, Okada Y, Ando H, Guedj M, Higashijima S, Shimazaki T, Chino N, Okano H, Okamoto H.
- Journal Title
  
  Dev Biol. 278
  
  Pages: 587-606
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells.2004
- Author(s)
  Okada Y, Shimazaki T, Sobue G, Okano H.
- Journal Title
  
  Dev Biol 275
  
  Pages: 124-142
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.2004
- Author(s)
  Yoshizaki T, Inaji M, Kouike H, Shimazaki T, Sawamoto K, Ando K, Date I, Kobayashi K, Suhara T, Uchiyama Y, Okano H
- Journal Title
  
  Neurosci Lett 363
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-14081207
[Journal Article] Down-regulation of STAT3 activation is required as an intrinsic factor to complete rod photoreceptor differentiation.2004
- Author(s)
  Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Gruss P, Hirano T, Oguchi Y, Okano H.
- Journal Title
  
  Mol Cell Neurosci 26
  
  Pages: 258-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.2004
- Author(s)
  Yoshizaki T, Inaji M., Kouike H., Shimazaki T, Sawamoto K, Ando K, Date I, Kobayashi K, Suhara T, Uchiyama Y, Okano H.
- Journal Title
  
  Neurosci Lett 363
  
  Pages: 33-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos.2003
- Author(s)
  Kokuzawa J, Yoshimura S, Kitajima H, Shinoda J, Kaku Y, Iwama T, Morishita R, Shimazaki T, Okano H, Kunisada T, Sakai N.
- Journal Title
  
  Mol Cell Neurosci 24
  
  Pages: 190-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Biology and clinical application of neural stem cells.2003
- Author(s)
  Shimazaki T.
- Journal Title
  
  Horm Res 60,Suppl 3
  
  Pages: 1-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.2003
- Author(s)
  Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S.
- Journal Title
  
  J.Neurosci. 23
  
  Pages: 1730-1741
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Flow cytometric analysis of neural stem cells in the developing and adult mouse brain.2002
- Author(s)
  Murayama, A., Matsuzaki, Y., Kawaguchi, A, Shimazaki.T., Okano, H.
- Journal Title
  
  J Neurosci Res 68
  
  Pages: 837-847
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Flow cytometric analysis of neural stem cells in the developing and adult mouse brain.2002
- Author(s)
  Murayama A, Matsuzaki Y, Kawaguchi A, Shimazaki T, Okano H.
- Journal Title
  
  J Neurosci Res 69
  
  Pages: 837-847
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Isolation and transplantation of dopaminergic neurons and neural stem cells.2002
- Author(s)
  Okano H, Yoshizaki T, Shimazaki T, Sawamoto K.
- Journal Title
  
  Parkinsonism Relat Disord. 1
  
  Pages: 23-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Brain from bone : efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent.2001
- Author(s)
  Kohyama J, Abe H, Shimazaki T, Koizumi A, Nakashima K, Gojo S, Taga T, Okano H, Hata J, Umezawa A.
- Journal Title
  
  Differentiation 68
  
  Pages: 235-244
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] The ciliary neurotrophic factor/leukemia inhibitory factor/gp 130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells.2001
- Author(s)
  Shimazaki T, Shingo T, Weiss S.
- Journal Title
  
  J Neurosci 21
  
  Pages: 7642-7653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells.2001
- Author(s)
  Shingo T, Sorokan ST, Shimazaki T, Weiss S.
- Journal Title
  
  J Neurosci 21
  
  Pages: 9733-9743
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Journal Article] EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord.2001
- Author(s)
  Represa A, Shimazaki T, Simmonds M, Weiss S.
- Journal Title
  
  Eur J Neurosci 14
  
  Pages: 452-462
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13480267
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PUBLICLY-19H04787
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K06469
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第42回日本神経科学大会/第62回日本神経化学会大会/ NEURO2019
- Data Source
  KAKENHI-PROJECT-18K06469
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第77回 Blood Vessel Club
- Data Source
  KAKENHI-PUBLICLY-19H04787
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第42回日本神経科学大会/第62回日本神経化学会大会/ NEURO2019
- Data Source
  KAKENHI-PUBLICLY-19H04787
[Presentation] Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.2019
- Author(s)
  加瀬義高、島崎琢也、岡野栄之
- Organizer
  第77回 Blood Vessel Club
- Data Source
  KAKENHI-PROJECT-18K06469
[Presentation] 神経幹細胞のグリア分化能を制御する発生時期特異的な因子の同定2015
- Author(s)
  津山　淳、　Jens Bunt、 Linda J. Richards、岩成　宏子、　望月康弘、浜窪隆雄、島崎　琢也、岡野　栄之
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PLANNED-22123004
[Presentation] 神経幹細胞のグリア分化能を制御する発生時期特異的な因子の同定2015
- Author(s)
  津山　　淳，島崎　琢也，岡野　栄之
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  虎ノ門ヒルズフォーラム（東京都港区）
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-15K06719
[Presentation] 神経幹/前駆細胞においてニューロン新生からグリア新生への切り替えを制御する調節因子2015
- Author(s)
  津山　　淳，島崎　琢也，岡野　栄之
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-15K06719

1. Yamamori Tetsuo (80260206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NAMIKI Jun (20189195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OKANO Hideyuki (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 影山龍一郎 (80224369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 後藤由季子 (70252525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 野田亮 (30146708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桝正幸 (20243032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大隅典子 (00220343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 三品昌美 (80144351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 森郁恵 (90219999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUYAMA Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Shimazaki Takuya 島崎 琢也

SHIMAZAKI Takuya 島崎 琢也

Research Projects

Research Products

Co-Researchers

Transcription factors regulating temporal specification of neuronal subtypes.Principal Investigator

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Regulatory mechanisms of aging of adult neural stem/progenitor cells via p38 MAPKPrincipal Investigator

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Mechanisms of glial developmentPrincipal Investigator

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Generation of Neural Diversity and Neocortex

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Mechanisms of neurogenesis and gliogenesis by neural stem cellsPrincipal Investigator

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Rejuvenation of neural stem cellsPrincipal Investigator

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Identification of neural stem cell survival factorPrincipal Investigator

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神経幹細胞の未分化性維持機構の解析Principal Investigator

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Review Section

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Bone Marrow Autograft for CNS Regeneration by Neural Stem Cells

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Mechanisms of Development and Regeneration of Mammalian Central Nervous SystemPrincipal Investigator

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[Journal Article] Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.2019

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Journal Title

DOI

Data Source

[Journal Article] Vertebrate Neural Stem Cells: Development, Plasticity, and Regeneration.2016

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Journal Title

DOI

NAID

Shimazaki Takuya 島崎琢也

SHIMAZAKI Takuya 島崎琢也