Takuma Hiroshi 詫間浩

… Alternative Names

TAKUMA Hiroshi 詫間浩

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Researcher Number	00326258
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 講師 2025: 帝京大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2015 – 2018: 帝京大学, 医学部, 講師 2011 – 2014: 筑波大学, 医学医療系, 講師 2007 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 講師 2001 – 2005: 大阪市立大学, 大学院・医学研究科, 助手 2004: Osaka City University, Graduate School of Medical Sciences, Research associate, 大学院医学研究科, 助手
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator General internal medicine (including Psychosomatic medicine) / Biological Sciences / Neurology
Keywords	Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / ADAR2 / RNA編集 / FTDP-17 / APP / RNA editing / microRNA / 細胞死 / 部位特異性 … More / siRNA / 前頭側頭型認知症 / 断片化 / マイクロRNA / 酵母 / mRNA / 皮質運動野 / dementia / splicing / exon 17 / tau / 細胞毒性 / TUNEL / カスパーゼ3 / アポトーシス / アミロイド蛋白 / 認知症 / スプライシング / エクソン10 / タウ / nicastrin / presenilin / sporadic Alzheimer's disease / 弧発性アルツハイマー病 / ニカストリン / プレセニリン / 孤発性アルツハイマー病 / 相互作用 / 細胞移動 / TAF15 / in vivo電気穿孔法 / 初代培養系 / Progranulin / ウイルスベクター / 電気穿孔法 / 多因子 / 筋萎縮性側索硬サ症 / RNA編集(エディティング) / 孤発性筋萎縮側索硬化症 / マイクロアレイ / 新規基質 … More Except Principal Investigator 脳神経疾患 / アルツハイマー病 / Plasma Aβ protein / Rivermead Behavioral Memory Test / MMSE / Mild cognitive impairment / Diabetes Mellitus / 臨床 / 血漿Aβ / 心理検査 / MCI / 認知症 / 糖尿病 / tauopachy / exon 10 / tau / neurodegeneration / splicing / Dementia / Neuroscience / タウ蛋白 / 老化 / 脳・神経 / タウオパチー / エクソン10 / タウ / スプライシング / 痴呆 / 神経科学 / APP / アミロイド前駆体蛋白（APP） / γ-secretase / BACE1 / 酸化ストレス / ミトコンドリア / アミロイドβ蛋白 Less

The therapeutic strategy for amyotrophic lateral sclerosis by elucidation and removal of accumulated protein-cleaving factorsPrincipal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Teikyo University
The strategy for treatment based on the association cascade with the amyotrophic lateral sclerosis causative genes and RNA editing enzymePrincipal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Teikyo University
  University of Tsukuba
Pathophysiology of Alzheimer's disease and mitochondrial dysfunction
- Principal Investigator
  
  TAMAOKA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Involvement of RNA-editing enzyme and multi-factor to motor neuron death in patients with sporadic amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Screening for new substrate and development of bio-marker for RNA editing enzyme in sporadic amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Study of the status of cognitive function in elderly diabetic patients
- Principal Investigator
  
  SHIMADA Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Osaka City University
Alternated splicing of tau in development and neurodegenerating disorders with dementia.Principal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
Fundamental study on the molecular mechanism for neuropathological changes of dementia
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
A study for the contribution of RNA editing abnormality in sporadic Alzheimer's disease.Principal Investigator
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University

[Book] ブレインサイエンス・レビュー　2014　筋萎縮性側索硬化症治療に向けた新規モデル開発とRNA関連因子2014
- Author(s)
  詫間　浩
- Total Pages
  20
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-25461266
[Journal Article] Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal2018
- Author(s)
  Murabe Naoyuki、Mori Takuma、Fukuda Satoshi、Isoo Noriko、Ohno Takae、Mizukami Hiroaki、Ozawa Keiya、Yoshimura Yumiko、Sakurai Masaki
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1 Pages: 16536-16536
- DOI
  10.1038/s41598-018-34961-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01975, KAKENHI-PROJECT-16K09681, KAKENHI-PLANNED-16H06460, KAKENHI-PROJECT-18H02547
[Journal Article] iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons2017
- Author(s)
  Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
- Journal Title
  
  Science Translational Medicine
  
  Volume: 9 Issue: 391 Pages: 391-391
- DOI
  10.1126/scitranslmed.aaf3962
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-17KT0108, KAKENHI-PUBLICLY-17H05670, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H05019, KAKENHI-PROJECT-17H06622, KAKENHI-PROJECT-15K06921, KAKENHI-PLANNED-26114009
[Journal Article] Third nerve palsy due to local inflammation associated with vascular compression: A case series.2016
- Author(s)
  Shimizu M, Tozaka N, Ishii A, Mamada N, Terada M, Takuma H, Tamaoka A
- Journal Title
  
  J Neurol Sci.
  
  Volume: 367 Pages: 365-7
- DOI
  10.1016/j.jns.2016.06.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09681
[Journal Article] Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.2016
- Author(s)
  Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S.
- Journal Title
  
  Brain Dev.
  
  Volume: 38 Issue: 3 Pages: 293-301
- DOI
  10.1016/j.braindev.2015.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461652, KAKENHI-PROJECT-25461266, KAKENHI-PROJECT-26870379, KAKENHI-PROJECT-15K09593
[Journal Article] Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis2014
- Author(s)
  Shioya A, Takuma H, Shiigai M, Ishii A, Tamaoka A
- Journal Title
  
  J Neurol Sci pii: S0022-510X(14)00359-1.
  
  Volume: 343(1-2) Issue: 1-2 Pages: 203-205
- DOI
  10.1016/j.jns.2014.05.055
- NAID
  120007136625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-25461266
[Journal Article] Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation2014
- Author(s)
  A. Iwata, K. Nagata, H. Hatsuta, H. Takuma, M. Bundo, K. Iwamoto, A. Tamaoka, S. Murayama, T. Saido and S. Tsuji
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 Issue: 3 Pages: 648-656
- DOI
  10.1093/hmg/ddt451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24116009, KAKENHI-PROJECT-24390220, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24700371, KAKENHI-PROJECT-25461266
[Journal Article] Amelioration of acylcarnitine profile using bezafibrate and riboflavin in a case of adult-onset glutaric acidemia type 2 with novel mutations of the electron transfer flavoprotein dehydrogenase (ETFDH) gene2014
- Author(s)
  Shioya A, Takuma H, Yamaguchi S, Ishii A, Hiroki M, Fukuda T, Sugie H, Shigematsu Y, Tamaoka A
- Journal Title
  
  J Neurol Sci
  
  Volume: 346(1-2) Issue: 1-2 Pages: 350-352
- DOI
  10.1016/j.jns.2014.08.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-25461266, KAKENHI-PROJECT-25461652
[Journal Article] Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol.
  
  Volume: 183(1) Issue: 1 Pages: 211-25
- DOI
  10.1016/j.ajpath.2013.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25461266
[Journal Article] Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".2013
- Author(s)
  Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa
- Journal Title
  
  Sci Transl Med.
  
  Volume: 5(188) Issue: 188
- DOI
  10.1126/scitranslmed.3005697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24591249
[Journal Article] A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.2013
- Author(s)
  Akamatsu, M., Takuma, H., Yamashita, T., Okada, T., Keino-Masu, K., Ishii, K., Kwak, S., Masu, M., and Tamaoka, A.
- Journal Title
  
  Neuroscience Research
  
  Volume: 77 Issue: 4 Pages: 234-241
- DOI
  10.1016/j.neures.2013.09.009
- NAID
  120007130577
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22123006, KAKENHI-PUBLICLY-24110502, KAKENHI-PROJECT-24591249, KAKENHI-PUBLICLY-25110709, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-25293065, KAKENHI-PROJECT-25461266, KAKENHI-PROJECT-25461269
[Journal Article] E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity2011
- Author(s)
  Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma H, Mori H, Irie K
- Journal Title
  
  Int J Alzheimers Dis
  
  Pages: 431320-431320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591071
[Journal Article] A mouse model of amyloid β oligomers : their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo2010
- Author(s)
  Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H
- Journal Title
  
  J Neurosci
  
  Volume: 30(14) Pages: 4845-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591071
[Journal Article] CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis Parkinson's Disease2010
- Author(s)
  Matsumoto L, Takuma H, Tamaoka A, Kurisaki H, Date H, Tsuji S, Iwata A
- Journal Title
  
  PLoSOne
  
  Volume: 5(11)
- NAID
  120007137835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591071
[Journal Article] Expression of TDP-43 in inflammatory myopathies and other muscle diseases2009
- Author(s)
  Ishii A, Takuma H, Tsuji H, Ohkoshi N, Tamaoka A
- Journal Title
  
  Neuromuscular Disorders
  
  Volume: 19(8-9) Pages: 651-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591071
[Journal Article] TgArc/Arg3.1-d4EGFP indicator mice : a versatile tool to study brain activity changes in vitro and in vivo2009
- Author(s)
  Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazawa Y, Shigemoto R, Kuhl D, Waters J, Seeburg PH, Osten P
- Journal Title
  
  J Neurosci Methods
  
  Volume: 184(1) Pages: 25-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591071
[Journal Article] Alnyloid β E22Δ variant induces synaptic alteration in mouse hippocampal slices2008
- Author(s)
  Takuma H, Teraoka R ,Mori H, Tomiyama T
- Journal Title
  
  Neuroreort 19
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599003
[Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia2008
- Author(s)
  Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H
- Journal Title
  
  Annals of Neurology 63
  
  Pages: 377-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599003
[Journal Article] A new amyloid b variant favoring oligomerization in Alzheimer-type dementia2008
- Author(s)
  Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H
- Journal Title
  
  Ann Neurol 63
  
  Pages: 377-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599003
[Journal Article] Amyloidb E22D variant induces synaptic alteration in mouse hippocampal slices2008
- Author(s)
  Takuma H, Teraoka R, Mori H, Tomiyama T
- Journal Title
  
  Neuroreport 19(6)
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599003
[Journal Article] A Japanese family with early-onset ataxia with motor and sensory neuropathy2007
- Author(s)
  Kobayashi S, Takuma H, Murayama S, Sakurai M, Kanazawa I
- Journal Title
  
  J Neurol Sci 254(1-2)
  
  Pages: 44-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599003
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki T
- Journal Title
  
  Arch. Neurol. 61(11)
  
  Pages: 1773-1776
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by casuase-3 in vivo.2004
- Author(s)
  Hiroshi Takuma
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 63(3)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590841
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H
- Journal Title
  
  J.Neuropathol.Exp.Neurol. 63(3)
  
  Pages: 255-2061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, T sutada T, Kawabata K, Mori H, Miki T
- Journal Title
  
  Arch.Neurol. 61(11)
  
  Pages: 1773-1776
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Hiroshi Takuma
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 63(3)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590841
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo2004
- Author(s)
  Hiroshi Takuma, Takami Tomiyama, Keisuke Kuida, Hiroshi Mori
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 63(3)
  
  Pages: 255-261
- Data Source
  KAKENHI-PROJECT-16590841
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H
- Journal Title
  
  J. Neuropathol. Exp. Neurol. 63(3)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki H.
- Journal Title
  
  Arch. Neurol. 61(11)
  
  Pages: 1773-1776
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H.
- Journal Title
  
  J. Neuropathol. Esp. Neurol. 63(3)
  
  Pages: 255-261
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Isoforms changes of tau protein during development in various species.2003
- Author(s)
  Takuma H, Arawaka S, Mori H
- Journal Title
  
  Dev. Brain Res. 142(2)
  
  Pages: 121-127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Isoforms changes of tau protein during development in various species.2003
- Author(s)
  Takuma H, Arawaka S, Mori H
- Journal Title
  
  Dev.Brain Res. 142(2)
  
  Pages: 121-127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Presentation] 子宮内電気穿孔法TDP-43遺伝子導入によるin vivo形成封入体の微細形態の検討2014
- Author(s)
  詫間浩、赤松恵、山下雄也、Hartmut Oehring、岡田拓也、桝和子、石井一弘、Gustav Jirikowski、郭伸、桝正幸、玉岡晃
- Organizer
  第55回日本神経学会総会
- Place of Presentation
  福岡国際センター
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25461266
[Presentation] Two japanese cases of adult onset myopathic form of glutaric acidemia type II2013
- Author(s)
  S Yamaguchi, K Yamada, H Kobayashi, T Takahashi, Y Hasegawa, J Purevsuren, T Ohkubo, M Watanabe, T Tsunemi, A Ishii, H Takuma, A Tamaoka, Y Shigematsu, S Fukuda
- Organizer
  12th International Congress of Inborn errors of Metablism
- Place of Presentation
  Barcelona（スペイン）
- Data Source
  KAKENHI-PROJECT-25461266
[Presentation] 筋萎縮性側索硬化症関連タンパク質：TDP-43封入体の形成ーマウス胎仔電気穿孔法による大脳皮質運動野への疾患関連遺伝子の導入2013
- Author(s)
  赤松恵、詫間浩、山下雄也、岡田拓也、石井一弘、桝和子、郭伸、桝正幸、玉岡晃
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25461266
[Presentation] マウス胎仔電気穿孔法による in vivo TDP-43 遺伝子導入と封入体形成の検討2013
- Author(s)
  詫間浩、赤松恵、山下雄也、岡田拓也、石井一弘、桝和子、郭伸、桝正幸、玉岡晃
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京・有楽町フォーラム
- Data Source
  KAKENHI-PROJECT-25461266
[Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立とアストロサイトへの分化2011
- Author(s)
  北岡志保, 月田香代子, 高橋和利, 沖田圭介, 近藤孝之, 吉川勝宇, 山脇聖子, 内藤素子, 鈴木茂彦, 和泉唯信, 梶龍兒, 詫間浩, 玉岡晃, 森田光哉, 中野今治, 川田明広, 中畑龍俊, 高橋良輔, 山中伸弥, 井上治久
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 封入体筋炎におけるフィラミン染色性の検討2011
- Author(s)
  詫間浩, 石井亜紀子, 石井一弘, 渡邊雅彦, 中馬越清隆, 冨所康志, 塩谷彩子, 玉岡晃
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] Pathogenesis of Amyotrophic Lateral Sclerosis and the future therapeutic aspect2011
- Author(s)
  Takuma H, Tamaoka A
- Organizer
  The first Bonn-Tsukuba Symposium in Medicine
- Place of Presentation
  Tsukuba
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] FTLD-TDPおよびALSに蓄積するTDP-43蛋白の凝集体構造に関する解析2011
- Author(s)
  辻浩史, 野中隆, 新井哲明, 山下万喜子, 亀谷富由樹, 細川雅人, 初田裕幸、高尾昌樹, 村山繁雄, 齊藤祐子, 長谷川成人, 秋山治彦, マン・デービット, 詫間浩, 玉岡晃
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 筋萎縮性側索硬化症患者白血球における新規RNA編集部位の検討2010
- Author(s)
  詫間浩、山下雄也、石井一弘、郭伸、玉岡晃
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] ヒト剖検脳におけるα-シヌクレイン遺伝子発現とDNAメチル化の解析2010
- Author(s)
  松本ルミネ, 岩田淳, 古和久朋, 詫間浩, 玉岡晃, 栗崎博司, 辻省次
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 筋萎縮性側索硬化症患者白血球における新規RNA editing部位の検討2010
- Author(s)
  詫間浩, 山下雄也, 石井一弘, 郭伸, 玉岡晃
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] SOD1遺伝子変異L144FVXを有する家族性ALSの臨床的特徴について2010
- Author(s)
  玉岡晃, 辻浩史, 詫間浩, 新井誠, 小幡菜々子, 糸川昌成, 新井哲明, 長谷川成人, 塩谷彩子, 石井亜紀子, 石井一弘, 秋山治彦
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 筋萎縮性側索硬化症に蓄積するTDP-43蛋白C末端断片に関する検討2010
- Author(s)
  辻浩史, 長谷川成人, 野中隆, 新井哲明, 山下万貴子, 亀谷富由樹, 秋山治彦, 詫間浩, 冨所康志, 中馬越清隆, 石井亜紀子, 石井一弘, 渡邊雅彦, 玉岡晃
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 筋萎縮性側索硬化症(ALS)におけるTDP-43遺伝子とタンパク質に関する検討2009
- Author(s)
  辻浩史, 長谷川成人, 亀谷富由樹, 野・イ, 新井哲明, 秋山治彦, 詫間浩, 冨所康志, 中馬越清隆, 石井亜紀子, 石井一弘, 渡邊雅彦, 玉岡晃
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] マイクロアレイを用いたRNA編集酵素(ADAR2)の新規基質の同定2009
- Author(s)
  詫間浩, 山下雄也, 郭伸, 玉岡晃
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21591071
[Presentation] 孤発性筋萎縮性側索硬化症におけうRNA編集酵素(ADAR2)の新規基質の検討2008
- Author(s)
  詫間浩、山下雄也、郭伸、玉岡晃
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  パシフィコ横浜 (横浜市)
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19599003
[Presentation] 孤発性筋萎縮性側索硬化症におけるRNA編集酵素(ADAR2)の新規基質の検討2008
- Author(s)
  詫間浩、山下雄也、郭伸、玉岡晃
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19599003
[Presentation] グルタミン酸受容体RNA編集欠損による筋萎縮性側索硬化症モデルマウス作成の試み2007
- Author(s)
  詫間浩・郭伸・玉岡晃
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-19599003
[Presentation] グルタミン酸受容体RNA編集欠損による筋萎縮性側索硬化症モデルマウス作成の試み2005
- Author(s)
  詫間浩、郭伸、玉岡晃、Peter H Seeburg
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2005-05-17
- Data Source
  KAKENHI-PROJECT-19599003
[Presentation] TDP-43 aggregation produced by In utero electroporation and its properties in the mouse motor neurons
- Author(s)
  M. AKAMATSU, H. TAKUMA, T. YAMASHITA, T. OKADA, K. ISHII, K. KEINO-MASU, S. KWAK, M. MASU, A. TAMAOKA
- Organizer
  Society for Neuroscience 43th Annual Meeting
- Place of Presentation
  San Diego Convention Center, USA
- Data Source
  KAKENHI-PROJECT-24591249
[Presentation] TDP-43 aggregation produced by In utero electroporation and its properties in the mouse motor neurons
- Author(s)
  M. AKAMATSU, H. TAKUMA, T. YAMASHITA, T. OKADA, K. ISHII, K. KEINO-MASU, S. KWAK, M. MASU, A. TAMAOKA
- Organizer
  Society for Neuroscience 43th Annual Meeting
- Place of Presentation
  San Diego Convention Center（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-25461266
[Presentation] Altered CpG methylation in sporadic Alzheimer’s disease is associated with APP and MAPT dysregulation
- Author(s)
  A. IWATA, K. NAGATA, H. HATSUTA, H. TAKUMA, M. BUNDO, K. IWAMOTO, A. TAMAOKA, S. MURAYAMA, T. C. SAIDO, S. TSUJI
- Organizer
  Society for Neuroscience 43th Annual Meeting
- Place of Presentation
  San Diego Convention Center（アメリカ合衆国）
- Data Source
  KAKENHI-PROJECT-25461266
[]
[]

1. TAMAOKA Akira (50192183)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
2. KWAK Shin (40160981)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. MORI Hiroshi (10159189)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. TOMIYAMA Takami (10305633)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. KAMEDA Hiroshi (10532749)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOMIDOKORO Yasushi (80447250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMADA Hiroyuki (90254391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 桜井正樹 (30162340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 塩谷彩子 (60622735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 前川裕美 (80399683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HOSOKAWA Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. IWATA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 森琢磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 福田冬季子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 杉江秀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岩本由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 桝和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 桝正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takuma Hiroshi 詫間 浩

TAKUMA Hiroshi 詫間 浩

Research Projects

Research Products

Co-Researchers

The therapeutic strategy for amyotrophic lateral sclerosis by elucidation and removal of accumulated protein-cleaving factorsPrincipal Investigator

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The strategy for treatment based on the association cascade with the amyotrophic lateral sclerosis causative genes and RNA editing enzymePrincipal Investigator

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Pathophysiology of Alzheimer's disease and mitochondrial dysfunction

Principal Investigator

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Involvement of RNA-editing enzyme and multi-factor to motor neuron death in patients with sporadic amyotrophic lateral sclerosisPrincipal Investigator

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Screening for new substrate and development of bio-marker for RNA editing enzyme in sporadic amyotrophic lateral sclerosisPrincipal Investigator

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Study of the status of cognitive function in elderly diabetic patients

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Alternated splicing of tau in development and neurodegenerating disorders with dementia.Principal Investigator

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Fundamental study on the molecular mechanism for neuropathological changes of dementia

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A study for the contribution of RNA editing abnormality in sporadic Alzheimer's disease.Principal Investigator

Principal Investigator

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[Book] ブレインサイエンス・レビュー 2014 筋萎縮性側索硬化症治療に向けた新規モデル開発とRNA関連因子2014

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[Journal Article] Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal2018

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[Journal Article] iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons2017

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[Journal Article] Third nerve palsy due to local inflammation associated with vascular compression: A case series.2016

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[Journal Article] Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.2016

Takuma Hiroshi 詫間浩

TAKUMA Hiroshi 詫間浩

[Book] ブレインサイエンス・レビュー　2014　筋萎縮性側索硬化症治療に向けた新規モデル開発とRNA関連因子2014