Nagai Toshio 永井敏雄

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NAGAI Toshio 永井敏雄

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Researcher Number	00334194
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2016: 千葉大学, 医学(系)研究科(研究院), 准教授 2013: 千葉大学, 大学院・医学薬学府, 准教授 2011: 千葉大学, 医学研究院, 准教授 2010 – 2011: 千葉大学, 大学院・医学研究院, 准教授 2009: 千葉大学, 大学院・医学研究院, 講師 2002 – 2006: 千葉大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Biological Sciences
Keywords	Principal Investigator 細胞移植 / 幹細胞 / 心筋再生 / DNA傷害 / side population細胞 / 心筋前駆細胞 / 循環器 / cardiovascular medicine / regenerative medicine / stem cell … More / )循環器 / 再生医療 / cardiomyocytes / cell fusion / transdifferentiation / stem cells / skeletal muscle / 前駆細胞 / 細胞生物学 / 骨格筋細胞 / 心筋細胞 / 細胞融合 / 形質転換 / 骨格筋 / パラクライン効果 / 細胞移植床 / 自己組織化ナノペプチド / 心筋梗塞 / 心筋幹/前駆細胞 / 分子心臓病態学 / JAM-A / leukemia inhibitory factor / 心臓side population細胞 / 内在性心臓幹細胞 / パラクライン因子 / 内在性心筋幹細胞 / 心臓前駆細胞 / 分子心臓学 / リプログラミング / 形質変換 … More Except Principal Investigator P19CL6細胞 / Csx / LIMタンパク / 転写因子 / Nkx2-5 / angiotensin II / ノックアウトマウス / PPARγ / 心不全 / 循環器・高血圧 / 核外移行シグナル / Wnt / 心筋分化 / knockout mice / protein kinase / P19Cl6 cell / zinc finger protein / LIM protein / transcriptional regulation / cardiomyocytes differentiation / タンパク質間相互作用 / Kruppel-associated box / リン酸化酵素 / P19C16細胞 / ジンクフィンガー / 転写制御 / 心臓発生 / knockout mouse / heart failure / cardiac hypertrophy / thiazolidinedione / チアゾリジン誘導体 / アンジオテンシンII / 心肥大 / IGFBP-4 / ES細胞 / C1q / 心筋細胞分化 / 多能性幹細胞 / 心筋細胞 / 間葉系幹細胞 / iPS細胞 / Wntシグナル / 発生・分化 / 心房細動 / 肥満細胞 / 伸展刺激 / 共培養 / nifedipine / side population / 骨格筋細胞 / GFP / 分化 / 遺伝子発現 / カルシウム / タシパク質間相互作用 / MEF2C / DNA chip / ATF-2 / Nkx2.5 / Smad / TAK1 / BMP / Cal / MEF2 / GATA4 / Midori / P19CL6 / CSX / 分化転換 / 発生 / 細胞融合 Less

Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model.Principal Investigator
- Principal Investigator
  
  Nagai Toshio
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Chiba University
Research on differentiation factor and niche for cardiac stem/progenitor cellsPrincipal Investigator
- Principal Investigator
  
  NAGAI TOSHIO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiberPrincipal Investigator
- Principal Investigator
  
  NAGAI TOSHIO
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases
- Principal Investigator
  
  KOMURO Issei
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
  Osaka University
  Chiba University
Analysis of rennin/histamine secreted from cardiac mast cells during heart failure
- Principal Investigator
  
  OKA Toru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
心筋/非心筋融合細胞を用いた心筋誘導因子の探究Principal Investigator
- Principal Investigator
  
  永井敏雄
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Establishment of clonal cardiac stem cells and identification of molecular mechanisms of cardiacPrincipal Investigator
- Principal Investigator
  
  NAGAI Toshio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Molecular Mechanisms of Cardiomyocyte Differentiation
- Principal Investigator
  
  KOMURO Issei
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Isolation and characterization of skeletal muscle-derived cardiac progenitor cells for cardiac regeneration therapyPrincipal Investigator
- Principal Investigator
  
  NAGAI Toshio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
心臓の発生分化における分子メカニズムの解明と心筋細胞分化誘導への応用
- Principal Investigator
  
  小室一成
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
ROLES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ IN CARDIOVASCULAR DISEASE
- Principal Investigator
  
  TAKANO Hiroyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  CHIBA UNIVERSITY
細胞分化による心不全の遺伝子治療
- Principal Investigator
  
  KOMURO Issei
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University

All 2016 2015 2014 2013 2012 2011 2010 2009 2005 2004 2003

All Journal Article Presentation Book

[Book] 講義録循環器学2004
- Author(s)
  永井敏雄
- Total Pages
  7
- Publisher
  構造と機能を学ぶ「血管の機能と病理」
- Data Source
  KAKENHI-PROJECT-15590720
[Book] 冠動脈の臨床(上)-21世紀の診断治療体系-II2003
- Author(s)
  永井敏雄
- Total Pages
  5
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.2016
- Author(s)
  Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 5 Pages: e0156562-e0156562
- DOI
  10.1371/journal.pone.0156562
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293180
[Journal Article] Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.2015
- Author(s)
  Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 6241-6241
- DOI
  10.1038/ncomms7241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390195, KAKENHI-PROJECT-25293180, KAKENHI-PROJECT-25670382, KAKENHI-PLANNED-26115008, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26670395, KAKENHI-PROJECT-26713028, KAKENHI-PROJECT-26870141, KAKENHI-PROJECT-15K15306
[Journal Article] Regeneration of the Cardiac Conduction System by Adipose Tissue-Derived Stem Cells2015
- Author(s)
  Takahashi T, Nagai T, Kanda M, Liu ML, Kondo N, Naito AT, Ogura T, Nakaya H, Lee JK, Komuro I, Kobayashi Y.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 12 Pages: 2703-2712
- DOI
  10.1253/circj.CJ-15-0400
- NAID
  130005110933
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460334, KAKENHI-PROJECT-26713028, KAKENHI-PROJECT-25293180
[Journal Article] Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction.2014
- Author(s)
  Liu ML, Nagai T, Tokunaga M, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Naito AT, Komuro I, Kobayashi Y.
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 3 Issue: 6
- DOI
  10.1161/jaha.114.001101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293180, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26713028
[Journal Article] Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.2014
- Author(s)
  Sun A, Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Ping P, Komuro I, Ge J.
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 3 Issue: 5
- DOI
  10.1161/jaha.113.000779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293180, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26670395
[Journal Article] Cardiac side population cells and Sca-1-positive cells2013
- Author(s)
  Nagai T, Matsuura K, Komuro I.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1036 Pages: 63-74
- DOI
  10.1007/978-1-62703-511-8_5
- ISBN
  9781627035101, 9781627035118
- Data Source
  KAKENHI-PROJECT-24659381, KAKENHI-PROJECT-25293180
[Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells2013
- Author(s)
  Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
- Journal Title
  
  Hypertens Res
  
  Volume: 36(10) Issue: 10 Pages: 859-65
- DOI
  10.1038/hr.2013.52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659417, KAKENHI-PROJECT-23689038, KAKENHI-PROJECT-24390195, KAKENHI-PROJECT-24659381, KAKENHI-PUBLICLY-25126706, KAKENHI-PROJECT-25293180, KAKENHI-PROJECT-25670382, KAKENHI-PROJECT-25670388
[Journal Article] Gene and cytokine therapy for heart failure : molecular mechanisms in the improvement of cardiac function2012
- Author(s)
  Nagai T, Komuro I
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390156
[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
- Author(s)
  Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
- Journal Title
  
  Cell
  
  Volume: 149 Issue: 6 Pages: 1298-1313
- DOI
  10.1016/j.cell.2012.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-22390156, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23390214, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-23659411, KAKENHI-PROJECT-23659417, KAKENHI-PROJECT-23689038, KAKENHI-PROJECT-24390195, KAKENHI-PROJECT-24659381, KAKENHI-PROJECT-24659390, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PUBLICLY-23126504
[Journal Article] Gene and cytokine therapy for heart failure : molecular mechanisms in the improvement of cardiac function2012
- Author(s)
  Nagai T, Komuro I.
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659381
[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
- Author(s)
  Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.
- Journal Title
  
  Cell
  
  Volume: 149 Pages: 1298-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659381
[Journal Article] Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function.2012
- Author(s)
  2. Nagai T
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 303 Issue: 5 Pages: H501-H512
- DOI
  10.1152/ajpheart.00130.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659381
[Journal Article] Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function.2012
- Author(s)
  Nagai T
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390156
[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
- Author(s)
  Fukushima N1, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
- Journal Title
  
  PLoS One
  
  Volume: 6(1371/journal.pone.0027901)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390156
[Journal Article] Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells2011
- Author(s)
  Gong H, Ma H, Liu M, Zhou B, Zhang G, Chen Z, Jiang G, Yan Y, Yang C, Kanda M, Wu J, Yuan J, Li L, Nagai T, Komuro I, Ge J, Zou Y
- Journal Title
  
  Peptides
  
  Volume: 32 Issue: 5 Pages: 1035-1041
- DOI
  10.1016/j.peptides.2011.01.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390156
[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
- Author(s)
  Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 12 Pages: e27901-e27901
- DOI
  10.1371/journal.pone.0027901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-22390156, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23591091
[Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010
- Author(s)
  Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
- Journal Title
  
  Circ Res
  
  Volume: 106 Issue: 11 Pages: 1692-1702
- DOI
  10.1161/circresaha.109.214346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-21390237, KAKENHI-PROJECT-22390156
[Journal Article] Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction2010
- Author(s)
  Tokunaga M, Liu ML, Nagai T, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Wang P, Naito AT, Komuro I
- Journal Title
  
  JMol Cell Cardiol
  
  Volume: 49 Issue: 6 Pages: 972-983
- DOI
  10.1016/j.yjmcc.2010.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390156
[Journal Article] Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice2009
- Author(s)
  Matsuura K, Honda A, Nagai T, Fukushima N, Iwanaga K, Tokunaga M, Shimizu T, Okano T, Kasanuki H, Hagiwara N, Komuro I
- Journal Title
  
  J Clin Invest
  
  Volume: 119 Pages: 2204-2217
- DOI
  10.1172/jci37456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010
[Journal Article] G-CSF prevents cardiac Remodeling after myocardial infarction by activating Jak/Stat in cardiomyocytes.2005
- Author(s)
  Harada, M., Qin, Y., Takano, H., Minamino, T., Zou, Y., Toko, H., Ohtsuka, M., Matsuura, K., Sano, M., Nishi, J., Akazawa, H., Kunieda, T., Zhu, W., Hasegawa, H., Kunisada, K., Nagai, T., Nakaya, H., Yamauchi-Takihara, K., Komuro, I.
- Journal Title
  
  Nat Med 11
  
  Pages: 305-311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209025
[Journal Article] G-CSF prevents cardiac Remodeling after myocardial infarction by activating Jak/Stat in cardiomyocytes.2005
- Author(s)
  Harada, M., Qin, Y., Takano, H., Minamino, T., Zou, Y., Toko, H., Ohtsuka, M., Matsuura, K., Sano, M., Nishi, J., Akazawa, H., Kunieda, T., Zhu, W., Hasegawa, H., Kunisada, K., Nagai, T., Nakaya, H., Yamauchi-Takihara, K., Komuro, I.
- Journal Title
  
  Nat Med
  
  Pages: 305-311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.2004
- Author(s)
  Akazawa, H., Kudoh, S., Mochizuki, N., Takekoshi, N., Takano, H., Nagai, T., Komuro, I.
- Journal Title
  
  J Cell Biol 164
  
  Pages: 395-405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure.2004
- Author(s)
  Akazawa, H., Komazaki, S., Shimomura, H., Terasaki, F., Zou, Y., Takano, H., Nagai, T., Komuro I.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 41095-41103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Cardiomyocytes fuse with surrounding non-cardiomyocyres and re-enter the cell cycle.2004
- Author(s)
  Matsuura, K., Wada, H., Nagai, T., Iijima, Y., Minmino, T., Sano, M., Akazawa, H., Molkentin J.D, Kasanuki, H., Komuro, I.
- Journal Title
  
  J Cell Biol 167
  
  Pages: 351-363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209025
[Journal Article] Adult cardiac Sea-1 positive cells differentiate into beating cardiomyocytes.2004
- Author(s)
  Matsuura, K., Nagai, T., Nishigaki, N., Oyama, T., Nishi, J., Wada, H., Sano, M., Toko, H., Akazawa, H., Sato, T., Nakaya, H, Kasanuki., H., Komuro, I.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 11384-11391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.2004
- Author(s)
  Akazawa, H., Kudoh, S., Mochizuki, N., Takekoshi, N., Takano, H., Nagai, T., Komuro, I.
- Journal Title
  
  J Cell Biol 164
  
  Pages: 395-405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209025
[Journal Article] Angiotensin II Type la Receptor Is Involved in Cell Infiltration, Cytokine Production, and Neovascularization in Infarcted Myocardium.2004
- Author(s)
  Toko, H., Zou, Y., Minamino, T., Sakamoto, M., Sano, M., Harada, M., Nagai, T., Sugaya, T., Terasaki, F., Kitaura, Y., Komuro, I.
- Journal Title
  
  Arterioscler Thromb Vase Biol 24
  
  Pages: 664-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] The role of PPAR γ-dependent pathway in the development of cardiac hypertrophy.2003
- Author(s)
  Takano, H., Hasegawa, H., Nagai, Tand Komuro, I.
- Journal Title
  
  Drugs of Today 39
  
  Pages: 347-357
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Stretch-modulation of second messengers : effects on cardiomyocyte ion transport.2003
- Author(s)
  Kudoh, S., Akazawa, H., Takano, H., Zou, Y., Toko, H., Nagai, T, Komuro, I.
- Journal Title
  
  Prog Biophys Mol Biol 82
  
  Pages: 57-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats.2003
- Author(s)
  Hasegawa, H., Yamamoto, R., Takano, H., Mizukami, M., Asakawa, M., Nagai, T.Komuro, I.
- Journal Title
  
  J Mol Cell Cardiol 35
  
  Pages: 923-960
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Cdc42 plays a critical role in assembly of sarcomere units series of cardiac myocytes.2003
- Author(s)
  Nagai, T., Tanaka-Ishikawa, M., Aikawa, R., Ishihara, H., Zhu, W., Yazaki, Y, Nagai, R., Komuro I.
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 806-810
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Cdc42 plays a critical role in assembly of sarcomere units series of cardiac myocytes.2003
- Author(s)
  Nagai T
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 806-810
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.2003
- Author(s)
  Zou, Y., Zhu, W., Sakamoto, M., Qin, Y., Akazawa, H., Toko, H., Mizukami, M., Takeda, N., Minamino, T., Takano, H., Nagai, T., Nakai, A., Komuro, I.
- Journal Title
  
  Circulation 108
  
  Pages: 3024-3030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Journal Article] Beating is necessary for transdiffentiation of skeletal muscle-derived cells into cardiomyocytes2003
- Author(s)
  Iijima, Y., Nagai, T., Mizukami, M., Matsuura, K., Ogura, T., Wada, T., Akazawa, H., Takano, H., Nakaya, H., Komuro, I.
- Journal Title
  
  FASEB J 17
  
  Pages: 1361-1363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590720
[Presentation] Novel Multicolor Lineage Tracing Model Can Detect Cardiomyocyte-Derived Cardiac Regeneration after Injury.2016
- Author(s)
  Kanda M, Nagai T, Takahashi T, Liu M, Kondou N, Naito A, Akazawa H, Komuro I, Kobayashi Y.
- Organizer
  第80回日本循環器学会総会・学術集会
- Place of Presentation
  仙台国際センター, 宮城県, 仙台市
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-25293180
[Presentation] Leukemia Inhibitory Factor Enhances Cardiomyocyte Regeneration after Myocardial Infarction from Endogenous stem Cells and not from Circulating Bone Marrow-derived Cells.2015
- Author(s)
  Kanda M, Nagai T, Takahashi T, Liu M, Kondou N, Naito A, Akazawa H, Komuro I, Kobayashi Y.
- Organizer
  European Society of Cardiology Congress 2015
- Place of Presentation
  London, UK
- Year and Date
  2015-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293180
[Presentation] A Novel Multicolor Lineage Tracing Model Can Detect Cardiomyocyte-Derived Cardiac Regeneration After Myocardial Infarction.2015
- Author(s)
  Kanda M, Nagai T, Takahashi T, Liu M, Kondou N, Naito A, Akazawa H, Komuro I, Kobayashi Y.
- Organizer
  American Heart Association Scientific Sessions 2015
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293180
[Presentation] 心筋再生治療の可能性2013
- Author(s)
  永井敏雄
- Organizer
  第17回日本心不全学会
- Place of Presentation
  大宮
- Invited
- Data Source
  KAKENHI-PROJECT-25293180
[Presentation] 心筋再生治療の可能性2013
- Author(s)
  永井敏雄
- Organizer
  第17回日本心不全学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-24659381
[Presentation] 内在性心筋幹/前駆細胞による心筋再生2012
- Author(s)
  永井敏雄
- Organizer
  日本心脈管作動物質学会シンポジウム
- Place of Presentation
  秋田
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 内在性心筋幹細胞による心筋再生2011
- Author(s)
  永井敏雄
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児島(招待講演)
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 内在性心筋幹細胞による心筋再生2011
- Author(s)
  永井敏雄
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 体性幹細胞移植による心筋再生の機序2010
- Author(s)
  永井敏雄
- Organizer
  第13回小児心血管分子医学研究会
- Place of Presentation
  東京
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 体性組織幹細胞?心筋幹細胞と脂肪組織幹細胞による心筋再生2010
- Author(s)
  永井敏雄
- Organizer
  2010 Tokyo Heart Dev Club
- Place of Presentation
  東京
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 体性組織幹細胞～心筋幹細胞と脂肪組織幹細胞による心筋再生2010
- Author(s)
  永井敏雄
- Organizer
  2010 Tokyo Heart Dev Club
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-22390156
[Presentation] 体性幹細胞移植による心筋再生の機序2010
- Author(s)
  永井敏雄
- Organizer
  第13回小児心血管分子医学研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-22390156

1. KOMURO Issei (30260483)

# of Collaborated Projects: 11 results

# of Collaborated Products: 28 results
2. SHIOJIMA Ichiro (90376377)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. TAKANO Hiroyuki (60334190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. OKA Toru (10332678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AKAZAWA Hiroshi (20396683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOSHIDA Katsuya (10191579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MINAMINO Tohru (90328063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 廣井透雄 (30311624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 内藤篤彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagai Toshio 永井 敏雄

NAGAI Toshio 永井 敏雄

Research Projects

Research Products

Co-Researchers

Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model.Principal Investigator

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Research on differentiation factor and niche for cardiac stem/progenitor cellsPrincipal Investigator

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Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiberPrincipal Investigator

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Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases

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Analysis of rennin/histamine secreted from cardiac mast cells during heart failure

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心筋/非心筋融合細胞を用いた心筋誘導因子の探究Principal Investigator

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Establishment of clonal cardiac stem cells and identification of molecular mechanisms of cardiacPrincipal Investigator

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Molecular Mechanisms of Cardiomyocyte Differentiation

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Isolation and characterization of skeletal muscle-derived cardiac progenitor cells for cardiac regeneration therapyPrincipal Investigator

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心臓の発生分化における分子メカニズムの解明と心筋細胞分化誘導への応用

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ROLES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ IN CARDIOVASCULAR DISEASE

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細胞分化による心不全の遺伝子治療

Principal Investigator

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Review Section

Research Institution

[Book] 講義録 循環器学2004

Author(s)

Total Pages

Nagai Toshio 永井敏雄

NAGAI Toshio 永井敏雄

[Book] 講義録循環器学2004