YAMASHITA Atsuya 山下篤哉

Researcher Number	00334871
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 山梨大学, 大学院総合研究部, 助教 2016: 山梨大学, 大学院・総合研究部, 助教 2014 – 2016: 山梨大学, 総合研究部, 助教 2011 – 2013: 山梨大学, 医学工学総合研究部, 助教 2012: 山梨大学, 大学院・医学工学総合研究部, 助教 2010: 山梨大学, 大学院・医学工学総合研究部, 助教 2004: University of Yamanashi, Faculty of Medicine, Research Associate, 大学院・医学工学総合研究部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Virology / Chemical biology / Virology
Keywords	Principal Investigator HBV / cccDNA / 抗ウイルス化合物 / HBx / 海洋生物 / 治療薬 / C型肝炎ウイルス / ウイルスプロモーター / 化合物スクリーニング系 / 抗ウイルス薬 … More / HBV cccDNA / 抗HBV化合物 / 転写機構 / ウィルス / 阻害化合物 / 可溶生物 / 化合物 / 転写制御 / 転写因子 / ケミカルバイオロジー / 創薬 / 治療薬開発 / HCV / 抗ウイルス剤 / 内科 / ウイルス / 慢性C型肝炎治療薬 / 肝臓学 … More Except Principal Investigator HBV / HCV / subtype C / ART / NF-κB / AIDS / 抗ウイルス化合物 / 宿主因子 / 宿主蛋白質 / 抗ウイルス剤 / B型肝炎 / C型肝炎 / ビフェニルエーテル / merosesquiterpene / PBDE / HCV NS3 helicase / メロセスキテルペン / サンゴ礁生物 / core promoter / NS3 helicase / national program / infectious clone / genotype / Zambia / 薬剤耐性 / 母子感染 / モニタリング / 抗HIV薬 / アフリカ / HIV-1 / エイズ / 感染性分子クローン / MTCT / VCT / HIV / 国家対策 / 感染性クローン / サブタイプC / ジェノタイプ / ザンビア / ヘパシウイルス / フラビウイルス / 非霊長類ヘパシウイルス / 人獣共通感染症 / C型肝炎ウイルス Less

HBV HBxを標的とした創薬の多角的アプローチ： cccDNA排除を目指してPrincipal Investigator
- Principal Investigator
  
  山下篤哉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Yamanashi
The search for anti-HBV compounds targeting the unique transcriptional regulatory mechanism of the HBV HBx protein.Principal Investigator
- Principal Investigator
  
  Yamashita Atsuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Yamanashi
Search for a novel seed compound of anti HBV agent targeting transcriptional control of HBV from Marine OrganismsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Atsuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Yamanashi
Development of anti-hepatitis virus strategy based on proteomics
- Principal Investigator
  
  MORIISHI Kohji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  University of Yamanashi
Search for antiviral molecules from coral reef organisms
- Principal Investigator
  
  TANAKA Junichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  University of the Ryukyus
Discovery and development of agents for chronic hepatitis C from marine natural productsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Atsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Yamanashi
Infection of hepatitis C virus-related non-primate hepacivirus in Japan and analysis on its replication mechanism
- Principal Investigator
  
  MORIISHI Kohji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Virology
- Research Institution
  University of Yamanashi
The role of microtubules structure in hepatitis C virus replicationand the possibility of its target molecule for anti-HCV agentPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Atsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Yamanashi
Biological and Socio-Medical Studies to Establish Anti-AIDS/HIV Strategies in Sub-Saharan Countries, Especially Zambia
- Principal Investigator
  
  YAMAMOTO Naoki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
  Tokyo Medical and Dental University

[Journal Article] Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action2022
- Author(s)
  Masaaki Toyama, Koichi Watashi, Masanori Ikeda, Atsuya Yamashita, Mika Okamoto, Kohji Moriishi, Masamichi Muramatsu, Takaji Wakita, Ashoke Sharon, Masanori Baba
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 66 Issue: 6
- DOI
  10.1128/aac.02073-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07980
[Journal Article] Deep sequencing analysis of serum hepatitis B virus-RNA during nucleot(s)ide analogue therapy2021
- Author(s)
  Shuya Matsuda, Shinya Maekawa, Yasuyuki Komiyama, Natsuko Nakakuki, Tatsuya Yamaguchi, Yasuhiro Nakayama, Taisuke Inoue, Tadashi Sato, Atsuya Yamashita, Kohji Moriishi, Nobuyuki Enomoto
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Issue: 1 Pages: 39-50
- DOI
  10.1111/hepr.13574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08439, KAKENHI-PROJECT-20K08281, KAKENHI-PROJECT-19H03638
[Journal Article] Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry2021
- Author(s)
  Tanaka Tomohisa、Okuyama-Dobashi Kaori、Motohashi Ryoji、Yokoe Hiromasa、Takahashi Kazunori、Wiriyasermkul Pattama、Kasai Hirotake、Yamashita Atsuya、Maekawa Shinya、Enomoto Nobuyuki、Ryo Akihide、Nagamori Shushi、Tsubuki Masayoshi、Moriishi Kohji
- Journal Title
  
  Antiviral Research
  
  Volume: 194 Pages: 105165-105165
- DOI
  10.1016/j.antiviral.2021.105165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07574, KAKENHI-PROJECT-19K08439, KAKENHI-PROJECT-20K08281, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-21H03365
[Journal Article] Induction of HOX Genes by Hepatitis C Virus Infection via Impairment of Histone H2A Monoubiquitination2021
- Author(s)
  Hirotake Kasai, Kazuki Mochizuki, Tomohisa Tanaka, Atsuya Yamashita, Yoshiharu Matsuura, Kohji Moriishi
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 6
- DOI
  10.1128/jvi.01784-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08439
[Journal Article] Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses2020
- Author(s)
  Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Nobuhiro Kobayashi, Atsuya Yamashita, Takasuke Fukuhara, Akihide Ryo, Moto Fukai, Akinobu Taketomi, Yoshiharu Matsuura, Kohji Moriishi
- Journal Title
  
  Hepatology Communications
  
  Volume: 5 Issue: 4 Pages: 634-649
- DOI
  10.1002/hep4.1653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08439
[Journal Article] Cancer-related genetic changes in multistep hepatocarcinogenesis and their correlation with imaging and histological findings2020
- Author(s)
  Masaru Muraoka, Shinya Maekawa, Yuichiro Suzuki , Mitsuaki Sato, Tatsuya Yamaguchi, Taisuke Inoue, Tadashi Sato, Atsuya Yamashita, Kohji Moriishi, Masanori Matsuda, Nobuyuki Enomoto
- Journal Title
  
  Hepatology Research
  
  Volume: 50 Issue: 9 Pages: 1071-1082
- DOI
  10.1111/hepr.13529
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08439, KAKENHI-PROJECT-20K08281, KAKENHI-PROJECT-19H03638
[Journal Article] HBV patients with low HBsAg and high HBcrAg titers have a high risk of HBV-related HCC.2019
- Author(s)
  Suzuki Y, Maekawa S, Komatsu N, Sato N, Tatsumi A, Miura M, Muraoka M, Nakakuki N, Shindo H, Amemiya F, Takano S, Nakayama Y, Fukasawa M, Yamaguchi T, Inoue T, Sato T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 1 Pages: 51-63
- DOI
  10.1111/hepr.13277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16K09349
[Journal Article] HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers.2019
- Author(s)
  Suzuki Y, Maekawa S, Komatsu N, Sato M, Tatsumi A, Miura M, Matsuda S, Muraoka M, Nakakuki N, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Inoue T, Sato T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 2 Pages: e0212559-e0212559
- DOI
  10.1371/journal.pone.0212559
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16K09349
[Journal Article] Roles of the 5' Untranslated Region of Nonprimate Hepacivirus in Translation Initiation and Viral Replication.2018
- Author(s)
  Tanaka T, Otoguro T, Yamashita A, Kasai H, Fukuhara T, Matsuura Y, Moriishi K.
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 7
- DOI
  10.1128/jvi.01997-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-15K18779
[Journal Article] Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress.2017
- Author(s)
  Amano R, Yamashita A, Kasai H, Hori T, Miyasato S, Saito S, Yokoe H, Takahashi K, Tanaka T, Otoguro T, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.
- Journal Title
  
  Antiviral Research
  
  Volume: 145 Pages: 123-130
- DOI
  10.1016/j.antiviral.2017.07.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16K09349, KAKENHI-PROJECT-15K08493
[Journal Article] Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity.2017
- Author(s)
  Yamashita A, Tamaki M, Kasai H, Tanaka T, Otoguro T, Ryo A, Maekawa S, Enomoto N, de Voogd NJ, Tanaka J, Moriishi K.
- Journal Title
  
  Antiviral Research
  
  Volume: 145 Pages: 136-145
- DOI
  10.1016/j.antiviral.2017.08.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16K09349
[Journal Article] Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia2017
- Author(s)
  Idam Hermawan, Atsushi Furuta, Masahiro Higashi, Yoshihisa Fujita, Nobuyoshi Akimitsu, Atsuya Yamashita, Kohji Moriishi, Satoshi Tsuneda, Hidenori Tani, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Naohiro Noda, Junichi Tanaka
- Journal Title
  
  Marine Drugs
  
  Volume: 15 Issue: 4 Pages: 117-117
- DOI
  10.3390/md15040117
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00778, KAKENHI-PROJECT-26350973, KAKENHI-PROJECT-26810008, KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16KT0165
[Journal Article] Hepatitis B virus prevents excessive 1 viral production via reduction of cell-death2017
- Author(s)
  Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S, Moriishi K
- Journal Title
  
  J Gen Virol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09348
[Journal Article] Catechol Group of Cinnamic Acid Derivative Is Essential for Its Anti-Hepatitis C Virus Activity.2017
- Author(s)
  Amano R, Yamashita A, Kasai H, Hori T, Miyasato S, Saito S,Tsubuki M, Moriishi K.
- Journal Title
  
  Yamanashi Medical Journal
  
  Volume: 32 Pages: 95-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09348
[Journal Article] Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx2016
- Author(s)
  Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y
- Journal Title
  
  J Virol
  
  Volume: 90 Issue: 7 Pages: 3530-3542
- DOI
  10.1128/jvi.02776-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15K08493
[Journal Article] Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity.2016
- Author(s)
  Otoguro T, Tanaka T, Kasai H, Yamashita A, Moriishi K.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 60 Issue: 11 Pages: 740-753
- DOI
  10.1111/1348-0421.12448
- NAID
  40021031203
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-16K09348
[Journal Article] Identification of antiviral agents targeting hepatitis B virus promoter from extracts of Indonesian marine organisms by a novel cell-based screening assay.2015
- Author(s)
  Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K
- Journal Title
  
  Marine Drug
  
  Volume: 13 Issue: 11 Pages: 6759-6773
- DOI
  10.3390/md13116759
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26350973, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-25460985
[Journal Article] Identification of hydroxyanthraquinones as novel inhibitors of hepatitis C virus helicase2015
- Author(s)
  Atsushi Furuta, Masayoshi Tsubuki, Miduki Endoh, Tatsuki Miyamoto, Junichi Tanaka, Kazi Abdus Salam, Nobuyoshi Akimitsu, Hidenori Tani, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Yuji Sekiguchi, Satoshi Tsuneda, Naohiro Noda
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Issue: 8 Pages: 18439-18453
- DOI
  10.3390/ijms160818439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350973, KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-26810100
[Journal Article] Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.2015
- Author(s)
  Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
- Journal Title
  
  Scientific reports
  
  Volume: 5 Issue: 1 Pages: 17047-17047
- DOI
  10.1038/srep17047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15H04735, KAKENHI-PROJECT-25460985
[Journal Article] Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus.2015
- Author(s)
  Sato M, Maekawa S, Komatsu N, Tatsumi A, Miura M, Muraoka M, Suzuki Y, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Uetake T, Inoue T, Sato T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
- Journal Title
  
  J Virol
  
  Volume: 89(11) Issue: 11 Pages: 6105-16
- DOI
  10.1128/jvi.03127-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-15K08995, KAKENHI-PROJECT-25460985
[Journal Article] Hallmarks of hepatitis C virus in equine hepacivirus.2015
- Author(s)
  Tanaka T, Kasai H, Yamashita A, Okuyama-Dobashi K, Yasumoto J, Maekawa S, Enomoto N, Okamoto T, Matsuura Y, Morimatsu M, Manabe N, Ochiai K, Yamashita K, Moriishi K.
- Journal Title
  
  J Virol.
  
  Volume: 88(22) Issue: 22 Pages: 13352-66
- DOI
  10.1128/jvi.02280-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-25460985
[Journal Article] Once-daily simeprevir in combination with pegylated-interferon and ribavirin: a new horizon in the era of direct-acting antiviral agent therapy for chronic hepatitis C.2014
- Author(s)
  Maekawa S, Enomoto N
- Journal Title
  
  J Gastroenterol.
  
  Volume: 49(1) Issue: 12 Pages: 163-164
- DOI
  10.1371/journal.pone.0082299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-24659204, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-25293110
[Journal Article] PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase.2014
- Author(s)
  Salam KA, Furuta A, Noda N, Tsuneda S, Sekiguchi Y, Yamashita A, Moriishi K, Nakakoshi M, Tani H, Roy SR, Tanaka J, Tsubuki M, Akimitsu N
- Journal Title
  
  Molecules
  
  Volume: 19 Issue: 4 Pages: 4006-4020
- DOI
  10.3390/molecules19044006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-26810100
[Journal Article] Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.2014
- Author(s)
  Furuta A, Salam KA, Hermawan I, Akimitsu N, Tanaka J, Tani H, Yamashita A, Moriishi K, Nakakoshi M, Tsubuki M, Peng PW, Suzuki Y, Yamamoto N, Sekiguchi Y, Tsuneda S, Noda N
- Journal Title
  
  Marine Drugs
  
  Volume: 12 Issue: 1 Pages: 462-476
- DOI
  10.3390/md12010462
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460985
[Journal Article] Serum RANTES level influences the response to pegylated interferon and ribavirin therapy in chronic hepatitis C.2013
- Author(s)
  Komase K, Maekawa S, Miura M, Sueki R, Kadokura M, Shindo H, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
- Journal Title
  
  Hepatol Res.
  
  Volume: 43(8) Issue: 8 Pages: 865-875
- DOI
  10.1111/hepr.12032
- NAID
  10031194591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-25460985
[Journal Article] Inhibition of hepatitis C virus NS3 helicase by cholesterol sulfate without inhibition of ATPase and RNA binding2013
- Author(s)
  Yamashita, A.; Moriishi, K.; Tsubuki, M.; Nakakoshi, M.; Sekiguchi, Y.; Tsuneda, S.; Noda, N
- Journal Title
  
  J. Enz. Inhib. Med. Chem
  
  Volume: 28 Issue: 2 Pages: 1-7
- DOI
  10.3109/14756366.2013.766607
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-25460985
[Journal Article] Psammaplin A inhibits hepatitis C virusNS3 helicase.2013
- Author(s)
  Salam KA, Yamashita A, et al.
- Journal Title
  
  J Nat Med.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression.2013
- Author(s)
  Miura M, Maekawa S, Takano S, Komatsu N, Tatsumi A, Asakawa Y, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
- Journal Title
  
  J Virol.
  
  Volume: 87(23) Issue: 23 Pages: 12541-12551
- DOI
  10.1128/jvi.00826-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-24590964
[Journal Article] IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication.2013
- Author(s)
  Shindo H
- Journal Title
  
  J Viral Hepat.
  
  Volume: 20 Issue: 4 Pages: 281-289
- DOI
  10.1111/j.1365-2893.2012.01649.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-24590964
[Journal Article] Serum RANTES level influences the responseto pegylated interferon and ribavirintherapy in chronic hepatitis C2013
- Author(s)
  Komase K, Yamashita A, Enomoto N, et al
- Journal Title
  
  Hepatol Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] IL-28B (IFN-λ3) and IFN-αsynergistically inhibit Shindo H HCVreplication.2013
- Author(s)
  Shindo H, Yamashita A, Enomoto N, et al
- Journal Title
  
  J Viral Hepat
  
  Volume: Vol.20, No.4 Pages: 281-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Cholesterol sulfate as a potentialinhibitor of hepatitis C virus NS3helicase.2013
- Author(s)
  Furuta A, Yamashita A, et al
- Journal Title
  
  J Enzyme Inhib Med Chem
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Psammaplin A inhibits hepatitis C virus NS3 helicase2013
- Author(s)
  Salam, K.A.; Furuta, A.; Noda, N.; Tsuneda, S.; Sekiguchi, Y.; Yamashita, A.; Moriishi, K.; Nakakoshi, M.; Tsubuki, M.; Tani, H.; Tanaka, J.; Akimitsu, N
- Journal Title
  
  J. Nat. Med. in press
  
  Volume: 67 Issue: 4 Pages: 765-772
- DOI
  10.1007/s11418-013-0742-7
- NAID
  40019787969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-24659204, KAKENHI-PROJECT-25460985
[Journal Article] Antimicrobial peptide LL-37 produced byHSV-2-infected keratinocytes enhances HIVinfection of Langerhans cells2013
- Author(s)
  Ogawa Y, Yamashita A, et al.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: Vol.13,No.1 Pages: 77-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Inhibition of hepatitis C virusreplication and viral helicase by ethylacetate extract of the marine feather starAlloeocomatella polycladia.2012
- Author(s)
  Yamashita A, Enomoto N, et al.
- Journal Title
  
  Mar Drugs.
  
  Volume: Vol.10,No.4 Pages: 744-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.2012
- Author(s)
  Fujimoto Y
- Journal Title
  
  PLoS One.
  
  Volume: 7 Issue: 11 Pages: 744-761
- DOI
  10.1371/journal.pone.0048685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-23590544, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659204, KAKENHI-PROJECT-24659359
[Journal Article] Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia2012
- Author(s)
  Yamashita A, Maekawa S, et al
- Journal Title
  
  Mar.Drugs
  
  Volume: 10 Issue: 4 Pages: 744-761
- DOI
  10.3390/md10040744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24659359
[Journal Article] Inhibition of both protease and helicaseactivities of hepatitis C virus NS3 by anethyl acetate extract of marine spongeAmphimedon sp.2012
- Author(s)
  Fujimoto Y, Yamashita A, Enomoto N, etal.
- Journal Title
  
  PLoS One
  
  Volume: Vol.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] Inhibition of hepatitis C virus NS3helicase by manoalide.2012
- Author(s)
  Salam KA, Yamashita A, et al.
- Journal Title
  
  J Nat Prod.
  
  Volume: Vol.75, No.4 Pages: 650-4
- Data Source
  KAKENHI-PROJECT-22590724
[Journal Article] A new method for induced fit docking(GENIUS) and its application to virtualscreening of novel HCV NS3-4A proteaseinhibitors2011
- Author(s)
  Takaya D, Yamashita A, Enomoto N, et al.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: Vol.19,No.22 Pages: 6892-905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] HBV Enhancer I-X promoter をターゲットとした抗HBV化合物の同定2023
- Author(s)
  山下篤哉, 葛西宏威, 田中智久, 大津直樹, 赤池康範, 前川伸哉, 榎本信幸, 森石恆司
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07980
[Presentation] Berberine, a plant-derived isoquinoline alkaloid, is the anti-HBV compound targeting the viral core promoter.2023
- Author(s)
  Atsuya Yamashita, Hirotake Kasai, Shinya Maekawa, Tomohisa Tanaka, Yasunori Akaike, Nobuyuki Enomoto, and Kohji Moriishi
- Organizer
  2023 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07980
[Presentation] 精神病薬Aripiprazole およびCariprazineの抗HBV活性機序の解析2023
- Author(s)
  山下篤哉、葛西宏威、田中智久、赤池康範、森石恆司
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07980
[Presentation] HBV Enhancer I-X promoterをターゲットとした抗HBV化合物の探索2022
- Author(s)
  山下篤哉, 葛西宏威, 田中智久, 大津直樹, 赤池康範, 前川伸哉, 榎本信幸, 森石恆司
- Organizer
  第30回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07980
[Presentation] HBV Enhancer I-X promoterをターゲットとした抗HBV化合物の同定とその抑制機序2022
- Author(s)
  山下篤哉、葛西宏威、田中智久、大津直樹、赤池康範、森石恆司
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07980
[Presentation] HBV Enhancer I-X promoterをターゲットとした抗HBV化合物の同定2021
- Author(s)
  山下篤哉, 田中智久, 葛西宏威, 森石恆司
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08439
[Presentation] C型肝炎ウイルス感染の宿主リン脂質構成への影響2019
- Author(s)
  葛西宏威、田中智久、山下篤哉、乙黒光姫、森石恆司
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08439
[Presentation] B型およびC型肝炎ウイルス感染を許容する培養細胞の樹立2019
- Author(s)
  乙黒光姫、田中智久、葛西宏威、山下篤哉、福原崇介、松浦善治、森石恆司
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08439
[Presentation] HBV感染に関与するcyclin-dependent kinaseの解析2019
- Author(s)
  田中智久、乙黒光姫、葛西宏威、山下篤哉、福原崇介、松浦善治、森石恆司
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08439
[Presentation] HBV core promoter をターゲットとした新規抗HBV化合物4,4'-bis(cyclohexylmethyl)biphenyl-2,2',5,5'-tetraol2019
- Author(s)
  山下篤哉, 田中智久, 乙黒光姫, 葛西宏威, 森石恆司
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08439
[Presentation] BeberineのHBV増殖抑制活性とその抑制機序の解明2018
- Author(s)
  山下篤哉, 田中智久, 葛西宏威, 乙黒光姫, 梁明秀, 前川伸哉, 榎本信幸, 森石恆司
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K09348
[Presentation] Berberine suppresses hepatitis B virus production via impairment of HBV core promoter activity.2018
- Author(s)
  山下篤哉、田中智久、乙黒光姫、葛西宏威、森石恆司
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09348
[Presentation] Establishment of hepatitis B and C virus co-infection cell line.2017
- Author(s)
  Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
- Organizer
  第65回日本ウイルス学会総会
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] 海洋生物由来テルペン系化合物metachromin AのHNF4α発現抑制作用によるHBV増殖抑制2017
- Author(s)
  山下篤哉、玉城麻友美、田中智久、葛西宏威、乙黒光姫、梁明秀、前川伸哉、榎本信幸、田中淳一、森石恆司
- Organizer
  第27回抗ウイルス療法学会　学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K09348
[Presentation] Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity2017
- Author(s)
  Atsuya Yamashita, Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, Kohji Moriishi
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09348
[Presentation] Hepatitis C virus infection impairs mono-ubiquitination of histone H2A and activates expression of homeobox genes.2016
- Author(s)
  Kasai H, Tanaka T, Yamashita A, Dobashi-Okuyama K, Moriishi K.
- Organizer
  第64回日本ウイルス学会総会
- Place of Presentation
  札幌コンベンションセンター（札幌白石区）
- Year and Date
  2016-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] Anti-HBV activity of Coptidis rhizoma alkaloids via targeting the viral core promoter.2016
- Author(s)
  Yamashita A, Tanaka T, Okuyama-Dobashi K, Kasai H, Moriishi K
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16K09348
[Presentation] Establishment of highly HBV-permissible HepG2 cell line to facilitate screening of antiviral compounds2016
- Author(s)
  Otoguro T, Tanaka T, Chen W, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K
- Organizer
  第64回日本ウイルス学会総会
- Place of Presentation
  札幌コンベンションセンター（札幌白石区）
- Year and Date
  2016-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] Cross-species compatibility of hepacivirus 5’ untranslated region2016
- Author(s)
  Tanaka T, Otoguro T, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K
- Organizer
  第64回日本ウイルス学会総会
- Place of Presentation
  札幌コンベンションセンター（札幌白石区）
- Year and Date
  2016-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] カイメン由来化合物metachromin A及びその類縁化合物の抗HBV活性の検討2015
- Author(s)
  山下篤哉、田中智久、葛西宏威、渡士幸一、脇田隆字、外山正明、馬場昌範、前川伸哉、榎本信幸、玉城麻友美、田中淳一、森石恆司
- Organizer
  第25回抗ウイルス療法学会総会
- Place of Presentation
  リーガロイヤルホテル東京
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26350973
[Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter2015
- Author(s)
  Atsuya Yamashita, Tomohisa Tanaka, Kaori Okuyama-Dobashi, Hirotake Kasai, Koichi Watashi, Takaji Wakita,, Masaaki Toyama, Masanori Baba, Mayumi Tamaki, Junichi Tanaka, Kohji Moriishi
- Organizer
  日本ウイルス学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth.2015
- Author(s)
  Jun Yasumoto， Hirotake Kasai， Tomohisa Tanaka， Koichi Watashi，Takaji Wakita，Atsuya Yamashita，Kaori Dobashi-Okuyama1，Kohji Moriishi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] 海綿由来セキステルペン系化合物metachromin AのB型肝炎ウイルスコアプロモーター抑制活性を介した抗ウイルス活性.2015
- Author(s)
  山下篤哉, 田中智久, 土橋香織, 葛西宏威, 渡士幸一, 脇田隆字, 外山正明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Characterization of the IRES activity in equine hepacivirus 5’UTR.2015
- Author(s)
  Tomohisa Tanaka，Chen Wenjia，Teruhime Otoguro，Hirotake Kasai，Atsuya Yamashita, Kohji Moriishi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Inhibitory effect of tyrphostin derivative HD-31 on hepatitis C virus replication via regulation of reactive oxygen species production.2015
- Author(s)
  Ryota Amano，Atsuya Yamashita，Hirotake Kasai，Kohji Moriishi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] プレセニリン阻害剤のC型肝炎ウイルス増殖抑制効果の検討2015
- Author(s)
  乙黒光姫、田中智久、葛西宏威、山下篤哉、森石恆司
- Organizer
  日本ウイルス学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] Infection of equine hepacivirus in a closed colony of Japanese native hors（2015
- Author(s)
  Tomohisa Tanaka, Wenjia Chen, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
- Organizer
  22nd International meeting on hepatitis C virus and related viruses
- Place of Presentation
  Palais de la Musique et des Congres (フランス、ストラスブール)
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] B型肝炎ウイルスコアプロモーター転写阻害剤のハイスループットスクリーニング.2015
- Author(s)
  古谷祐, 森田直子, 佐藤裕美, 山下篤哉, 森石恆司, 小嶋聡一
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Characterization of the IRES activity in equine hepacivirus 5’UTR2015
- Author(s)
  Tomohisa Tanaka, Wenjia Chen, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
- Organizer
  日本ウイルス学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] Inhibitory effect of tyrphostin derivative HD-31 on hepatitis C virus replication via regulation of reactive oxygen species production.2015
- Author(s)
  Ryota Amano, Atsuya Yamashita, Hirotake Kasai, Kohji Moriishi
- Organizer
  日本ウイルス学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08493
[Presentation] カイメン由来化合物metachromin A及びその類縁化合物の抗HBVの検討2015
- Author(s)
  山下篤哉, 田中智久, 葛西宏威, 渡士幸一, 脇田隆字, 外山正明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
- Organizer
  第25回抗ウイルス療法学会
- Place of Presentation
  国立感染症研究所（東京都新宿区）
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Screening of presenilin inhibitors for identification of anti-HCV compound.2015
- Author(s)
  Teruhime Otoguro，Tomohisa Tanaka，Hirotake Kasai，Atsuya Yamashita，Kohji Moriishi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter.2015
- Author(s)
  Atsuya Yamashita, Tomohisa Tanaka, Kaori Okuyama-Dobashi, Hirotake Kasai, Koichi Watashi, Takaji Wakita, Masaaki Toyama, Masanori Baba, Kohji Moriishi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Caffeic acid phenythyl esterとその類縁化合物によるHCVゲノム複製阻害2013
- Author(s)
  山下篤哉、沈暉、田中智久、葛西宏威、森石恆司
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] B型肝炎ウイルス感染による宿主細胞の超微形態変化の解析2013
- Author(s)
  安本順、葛西宏威、吉村健太郎、山下篤哉、田中智久、竹田扇、森石恆司
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Caffeic acid phenethyl esterとその類縁化合物によるHCVゲノム複製阻害2013
- Author(s)
  山下篤哉、沈暉、田中智久、葛西宏威、森石恆司
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市中央区）
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] 日本産ウマの血清から分離したnon-primate hepacivirusの性状解析2013
- Author(s)
  田中智久、葛西宏威、山下篤哉、森石恆司
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] 日本産馬の血清から分離したnon-primate hepacivirusの性状解析2013
- Author(s)
  田中智久、葛西宏威、山下篤哉、森石恆司
- Organizer
  第61回　日本ウイルス学会総会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation]2013
- Author(s)
  Tanaka T, Kasai H, Yamashita A, Moriishi K.
- Organizer
  20^<th> International Symposium on Hepatitis C virus and related viruses
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Tyrphostinとその類縁化合物によるC型肝炎ウイルス複製阻害2013
- Author(s)
  天野稜大、山下篤哉、葛西宏威、田中智久、前川伸哉、榎本信幸、津吹政可、森石恆司
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Probe electrospray Ionization質量分析法(PESI-MS)を用いたHCV感染細胞内脂質組成の解析2013
- Author(s)
  葛西宏威、吉村健太郎、安本順、山下篤哉、田中智久、竹田扇、森石恆司
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Identification and characterization of the non-primate hepaciviruses isolated from Japanese-born domestic horses2013
- Author(s)
  Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, and Kohji Moriishi
- Organizer
  20th International meeting on HCV and the related viruses
- Place of Presentation
  メルボルン国際会議場（メルボルン、オーストラリア）
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Tyrphostinとその類縁化合物によるC型肝炎ウイルス複製阻害2013
- Author(s)
  天野稜大、山下篤哉、葛西宏威、田中智久、前川伸哉、榎本信幸、津吹政可、森石恆司
- Organizer
  第36会日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市中央区）
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] Caffeic acid phenethyl esterとその類縁化合物によるHCVゲノム複製阻害2013
- Author(s)
  山下篤哉、沈暉、田中智久、葛西宏威、森石恆司
- Organizer
  第61回　日本ウイルス学会総会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] 海綿Amphimedon sp.抽出画分のHCVゲノム複製阻害効果とその作用機序2013
- Author(s)
  山下篤哉、藤本雄介、Kazi Abdus Salam、古田篤史、谷英典、前川信哉、榎本信幸、中越雅道、津吹政可、関口勇地、常田聡、秋光信佳、野田尚宏、田中淳一、森石恆司
- Organizer
  第23回抗ウイルス療法研究会総会
- Place of Presentation
  リーガロイヤルホテル東京（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] 海綿動物Amphimedon sp.抽出画分によるHCVNS3プロテアーゼ・ヘリカーゼ活性阻害の解析2012
- Author(s)
  藤本雄介、山下篤哉、池田正徳、加藤宣之、森石恆司
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] FKBP6 plays an important role in HCV replication through binding to HCV NS5A2012
- Author(s)
  Kasai H., Kawakami, K., Yamashita, A., Ikeda, M., Kato, N., Enomoto, N., Matsuura, Y., Kusunoki, M., Moriishi, K.
- Organizer
  19^<th> International Symposium on Hepatitis C virus and related viruses
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Caffeic acid phenethyl ester とその類縁化合物による HCV ゲノム複製阻害効果の検討2012
- Author(s)
  山下篤哉
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  グランキューブ大阪(大阪市)
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] 新規宿主因子FKBP6によるHCV複製制御機構の解析2012
- Author(s)
  葛西宏威、河上國洋、平田有佳理、山下篤哉、池田正徳、加藤宣之、岡本徹、松浦善治、楠木正己、森石恆司
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.2012
- Author(s)
  Atsuya Yamashita
- Organizer
  25th International Conference on Antiviral Research
- Place of Presentation
  Royton Sapporo (Sapporo, Japan)
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] Inhibition of hepatitis C virusreplication and viral helicase by ethylacetate extract of the marine feather starAlloeocomatella polycladia2012
- Author(s)
  Atsuya Yamashita
- Organizer
  25th International Conference onAntiviral Research
- Place of Presentation
  RoytonSapporo (Sapporo, Japan)
- Year and Date
  2012-04-16
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] Caffeic acid phenethyl esterとその類縁化合物によるHCVゲノム複製阻害効果の検討2012
- Author(s)
  山下篤哉
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  グランキューブ大阪（大阪市）
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] Caffeic acid phenethyl esterとその類縁化合物によるHCVゲノム複製阻害効果の検討2012
- Author(s)
  山下篤哉、沈暉、葛西宏威、藤本雄介、森石恆司
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24659204
[Presentation] Marine natural products as a source of the novel antiviral agent targeting to HCV NS3 helicase2011
- Author(s)
  Atsuya Yamashita
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo Convention Center (Sapporo, Japan)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] 海洋生物をライブラリーソースとした HCVNS3 Helicase 活性阻害化合物の検索2011
- Author(s)
  山下篤哉
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(金沢市)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] In silico分子設計手法によるHCV NS3protease活性阻害化合物の創製2011
- Author(s)
  山下篤哉
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(金沢市)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] In silico分子設計手法によるHCV NS3 protease活性阻害化合物の創製2011
- Author(s)
  山下篤哉
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川県)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] Marine natural products as a source of thenovel antiviral agent targeting to HCV NS3helicase2011
- Author(s)
  Atsuya Yamashita
- Organizer
  International Union of MicrobiologicalSocieties 2011 Congress
- Place of Presentation
  Sapporo Convention Center (Sapporo,Japan)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] 海洋生物をライブラリーソースとしたHCV NS3 Helicase活性阻害化合物の検索2011
- Author(s)
  山下篤哉
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川県)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] 沖縄産ウミシダ(Alloeocomatela polycladia)抽出物の抗HCV NS3 helicase阻害活性によるHCV増殖抑制効果2010
- Author(s)
  山下篤哉
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-22590724
[Presentation] カフェ酸類縁化合物によるHCVゲノム複製阻害
- Author(s)
  山下篤哉、沈暉、天野稜大、中越雅道、横江弘雅、須藤誠士、田中智久、葛西宏威、進藤浩子、
- Organizer
  第24回抗ウイルス療法研究会
- Place of Presentation
  ハイランドリゾートホテル（山梨県富士吉田市）
- Year and Date
  2014-05-07 – 2014-05-09
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] 海洋生物抽出物ライブラリーソースとしたB型肝炎ウイルス転写活性抑制化合物の探索
- Author(s)
  山下篤哉、藤本雄介、児玉栄一、田中智久、葛西宏威、前川伸哉、榎本信幸、田中淳一、
- Organizer
  第24回抗ウイルス療法研究会
- Place of Presentation
  ハイランドリゾートホテル（山梨県富士吉田市）
- Year and Date
  2014-05-07 – 2014-05-09
- Data Source
  KAKENHI-PROJECT-25460985
[Presentation] 海洋生物抽出物ライブラリーソースからのB型肝炎ウイルス転写活性抑制化合物の探索
- Author(s)
  山下篤哉、藤本雄介、田中智久、葛西宏威、児玉栄一、渡士幸一、脇田隆字、前川伸哉、
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25460985
[]
[]

1. MORIISHI Kohji (90260273)

# of Collaborated Projects: 5 results

# of Collaborated Products: 52 results
2. ENOMOTO Nobuyuki (20251530)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. KASAI Hirotake (20324189)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
4. YAMAMOTO Naoki (00094053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TANAKA Junichi (20163529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. NODA Naohiro (70415727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. SEKIGUCHI Yuji (20313570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TANI Hidenori (10635329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. TSUNEDA Satoshi (30281645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. AKIMITSU Nobuyoshi (40294962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. TSUBUKI Masayoshi (90163865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. FUJITA Yoshihisa (20771463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HIGASHI Masahiro (20611479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. TANAKA Tomohisa (30585310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
15. 照沼裕 (50217436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIURA Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. KOMATSU Nobutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 前川伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
19. 渡士幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Atsuya 山下 篤哉

Research Projects

Research Products

Co-Researchers

HBV HBxを標的とした創薬の多角的アプローチ： cccDNA排除を目指してPrincipal Investigator

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The search for anti-HBV compounds targeting the unique transcriptional regulatory mechanism of the HBV HBx protein.Principal Investigator

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Search for a novel seed compound of anti HBV agent targeting transcriptional control of HBV from Marine OrganismsPrincipal Investigator

Principal Investigator

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Development of anti-hepatitis virus strategy based on proteomics

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Search for antiviral molecules from coral reef organisms

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Discovery and development of agents for chronic hepatitis C from marine natural productsPrincipal Investigator

Principal Investigator

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Infection of hepatitis C virus-related non-primate hepacivirus in Japan and analysis on its replication mechanism

Principal Investigator

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The role of microtubules structure in hepatitis C virus replicationand the possibility of its target molecule for anti-HCV agentPrincipal Investigator

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Biological and Socio-Medical Studies to Establish Anti-AIDS/HIV Strategies in Sub-Saharan Countries, Especially Zambia

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[Journal Article] Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action2022

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[Journal Article] Deep sequencing analysis of serum hepatitis B virus-RNA during nucleot(s)ide analogue therapy2021

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[Journal Article] Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry2021

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[Journal Article] Induction of HOX Genes by Hepatitis C Virus Infection via Impairment of Histone H2A Monoubiquitination2021

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[Journal Article] Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses2020

Author(s)

YAMASHITA Atsuya 山下篤哉