Akiba Jun 秋葉純

… Alternative Names

AKIBA Jun 秋葉純

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Researcher Number	00341305
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 教授 2025: 久留米大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 久留米大学, 大学病院, 教授 2016 – 2017: 久留米大学, 大学病院, 准教授 2007 – 2009: 久留米大学, 医学部, 講師
Review Section/Research Field	Except Principal Investigator Basic Section 49020:Human pathology-related / Experimental pathology / Basic Section 57060:Surgical dentistry-related / Basic Section 55020:Digestive surgery-related / General internal medicine(including psychosomatic medicine)
Keywords	Except Principal Investigator 肝細胞癌 / マイクロアレイ / 免疫染色 / 免疫チェックポイント分子 / 口腔扁平上皮癌 / クロストーク解析 / がん幹細胞 / 原発性肝癌 / 細胆管癌 / 動脈硬化 … More / 脂肪性肝疾患 / マイクロダイセクション / 門脈侵襲 / バイオマーカー / 門脈浸潤 / 網羅的解析 / 細胆管型 / FFPE / 肝ステム像 / 組織診断 / HepPar-1 / ケラチン19 / ケラチン7 / 診断マーカー / 網羅的遺伝子解析 / 中間細胞亜型 / 胆管細胞癌 / 遺伝子発現 / 組織診断マーカー / 中間細胞型 / 混合型肝癌 / 生体分子 / アプタマー / 終末糖化産物 / 抗酸化因子 / Pyrotosis / 酸化ストレス / AGEs / 非アルコール性肝炎 / インフラマソーム / AGEｓ / PEDF / 肝癌 / NASH / 肝線維化 / 胆汁鬱滞性肝障害 / 柴苓湯 / アクアポリン / 茵ちん蒿湯 / 胆道閉鎖症 / TRAIL receptor / TRAIL / Cox-2阻害剤 / p21 / 細胞株 / 細胞周期 / NFκB阻害剤 / チロシンキナーゼ阻害剤 / ヌードマウス / ベバシズマブ / 血管内皮細胞増殖因子 / 分子標的薬剤 / 阻害剤 / アポトーシス / インターフェロン / サイトカイン / 腫瘍 Less

病理組織による脂肪性肝疾患の動脈硬化性疾患発症リスク予測モデルの確立
- Principal Investigator
  
  近藤礼一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kurume University
新規治療法を目指した細胆管細胞癌の臨床病理学解析およびゲノム解析による統合解析
- Principal Investigator
  
  石井隆道
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
口腔癌の癌幹細胞と周囲微小環境とのクロストーク機構解析による新規治療戦略の確立
- Principal Investigator
  
  轟圭太
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kurume University
Identification of key molecules controlling portal vein invasion of hepatocellular carcinoma
- Principal Investigator
  
  Yano Hirohisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kurume University
Identification of diagnostic marker of combined hepatocellular-cholangiocarcinoma subtypes by gene expression analysis
- Principal Investigator
  
  YANO Hirohisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kurume University
Prevention of NASH and NASH-related hepatocellular carcinoma by intrinsic anti-oxidative factor
- Principal Investigator
  
  YOSHIDA TAKAFUMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kurume University
he herbal medicines Inchinkoto and Saireito exert beneficial effects of reducing hepatic fibrosis in bile duct ligation rat liver
- Principal Investigator
  
  Yagi Minoru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kurume University
Basic studies on the treatment and prevention of hepatocellular carcinoma with interferon
- Principal Investigator
  
  YANO Hirohisa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kurume University

All 2019 2018 2017 2008 2007

All Journal Article Presentation

[Journal Article] Malic enzyme 1 is a potential marker of combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell type.2019
- Author(s)
  Mihara Y, Akiba J, Ogasawara S, Kondo R, Fukushima H, Itadani H, Obara H, Kakuma T, Kusano H, Naito Y, Okuda K, Nakashima O, Yano H.
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中 Issue: 9 Pages: 1066-1075
- DOI
  10.1111/hepr.13365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15106, KAKENHI-PROJECT-18K07032
[Journal Article] Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice2017
- Author(s)
  Yoshida Takafumi、Akiba Jun、Matsui Takanori、Nakamura Kazuo、Hisamoto Takao、Abe Mitsuhiko、Ikezono Yu、Wada Fumitaka、Iwamoto Hideki、Nakamura Toru、Koga Hironori、Yamagishi Sho-ichi、Torimura Takuji
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 62 Issue: 6 Pages: 1527-1536
- DOI
  10.1007/s10620-017-4550-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08776
[Journal Article] STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury.2017
- Author(s)
  Abe M, Yoshida T, Akiba J, Ikezono Y, Wada F, Masuda A, Sakaue T, Tanaka T, Iwamoto H, Nakamura T, Sata M, Koga H, Yoshimura A, Torimura T.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Issue: 37 Pages: 6833-6844
- DOI
  10.3748/wjg.v23.i37.6833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09385, KAKENHI-PROJECT-17K08776
[Journal Article] Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK12017
- Author(s)
  Yu Ikezono
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 不明 Issue: 6 Pages: 744-752
- DOI
  10.1158/1541-7786.mcr-16-0285
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19355, KAKENHI-PROJECT-17K08776
[Journal Article] Growth inhibitory effects of pegylated IFN-a2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.2008
- Author(s)
  Moriya F., Ogasawara S., Basaki Y., Akiba J., Kojiro S., Fukahori S., Ishizaki H., Nishida N., Matsuoka K., Kojiro M., Kuwano M., Yano H.
- Journal Title
  
  Int J Oncol 33
  
  Pages: 647-655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590412
[Journal Article] Growth inhibitory effects of IFN-βon human liver cancer cells in vitro and in vivo Journal of Interferon & Cytokine Research2007
- Author(s)
  Ogasawara S, Yano H, Momosaki S, Akiba J, Nishida N, Kojiro S, Moriya F, Ishizaki H, Kuratomi K, Kojiro M.
- Journal Title
  
  27
  
  Pages: 507-516
- Data Source
  KAKENHI-PROJECT-19590412
[Journal Article] X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expression and their relationship to apoptosis in human hepatocellular carcinoma and non-carcinomatous liver tissues Oncology Reports2007
- Author(s)
  Sakemi, R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Michio S, Kojiro M.
- Journal Title
  
  18
  
  Pages: 65-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590412
[Presentation] Malic enzyme 1（ME1）は混合型肝癌中間細胞亜型の診断マーカーとして有用である2019
- Author(s)
  三原勇太郎、秋葉純、小笠原幸子、近藤礼一郎、福嶋浩人板谷啓、草野弘宣、内藤嘉紀、中島収、矢野博久
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07032
[Presentation] Malic enzyme 1 is a potential marker of combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell type2019
- Author(s)
  Hirohisa Yano, Yutaro Mihara, Jun Akiba, Sachiko Ogasawara
- Organizer
  2019 Annual Meeting of Laennec Liver Pathology Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07032
[Presentation] Malic enzyme 1（ME1）は混合型肝癌中間細胞亜型の診断マーカーとして有用である2019
- Author(s)
  三原勇太郎、秋葉純、小笠原幸子、近藤礼一郎、福嶋浩人、板谷啓，草野弘宣、内藤嘉紀、中島収、矢野博久
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07032
[Presentation] The herbal medicines Inchinkoto and Saireito exert beneficial effects of reducing hepatic fibrosis in bile duct ligation rat liver2018
- Author(s)
  Naoki Hashizume,Minoru Yagi, Ryusuke Shin, Jun Akiba, Naoki Sotogaku, Akihiro Nishi, Hideaki Egami
- Organizer
  31st International symposium on Pediatric Surgical Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08941

1. YANO Hirohisa (40220206)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. OGASAWARA Sachiko (40258405)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. 中山正道 (80795229)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Yagi Minoru (10251802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YOSHIDA TAKAFUMI (30368899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 谷川健 (30289491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 恵紙英昭 (40248406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 橋詰直樹 (80569434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 三原勇太郎 (20869086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 近藤礼一郎 (50705217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石井隆道 (70456789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小無田美菜 (30441653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小木曾聡 (10804734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 波多野悦朗 (80359801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 轟圭太 (60624434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 河原明彦 (00469347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 安陪由思 (50748712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 植田浩介 (60569440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 草野弘宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 中村徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 鳥村拓司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 岩本英希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 池園友

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiba Jun 秋葉 純

AKIBA Jun 秋葉 純

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[Journal Article] Malic enzyme 1 is a potential marker of combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell type.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK12017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Growth inhibitory effects of pegylated IFN-a2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.2008

Author(s)

Journal Title

Data Source

[Journal Article] Growth inhibitory effects of IFN-βon human liver cancer cells in vitro and in vivo Journal of Interferon & Cytokine Research2007

Author(s)

Journal Title

Data Source

[Journal Article] X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expression and their relationship to apoptosis in human hepatocellular carcinoma and non-carcinomatous liver tissues Oncology Reports2007

Author(s)

Journal Title

Data Source

[Presentation] Malic enzyme 1（ME1）は混合型肝癌中間細胞亜型の診断マーカーとして有用である2019

Author(s)

Organizer

Akiba Jun 秋葉純

AKIBA Jun 秋葉純