Hamada Keisuke 浜田恵輔

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HAMADA Keisuke 浜田恵輔

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Researcher Number	00344052
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 横浜市立大学, 医学部, 助教 2008 – 2009: Yokohama City University, 医学部, 助教 2007: Yokohama City University, 医学研究科, 助教 2004 – 2006: 横浜市立大学, 医学部, 助手 2005: 横浜市立大学, 大学院(医学部)医学研究科, 助手 2003: 独立行政法人理化学研究所, 構造生物物理研究室, 基礎科学特別研究員 2002: 理化学研究所, 構造生物物理学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry / Molecular biology Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Chemical biology / Biological Sciences / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator X線結晶構造解析 / 基質特異性 / ペプチド創薬 / 酵素反応機構 / プレニル基転移酵素 / 酵素基質特異性 / 結晶構造解析 / ヒストンアセチル化酵素 / ヌクレオソーム会合因子 / クロマチンリモデリング因子 … More / 転写制御 / クロマチン構造変換 / 解毒反応 / 膜蛋白質 / 細胞膜結合型グルタチオン転移酵素 / 膜結合型グルタチオン転移酵素 / 膜タンパク質 / GoLocoモチーフ / Golocoモチーフ / LGN / 3量体G蛋白質 … More Except Principal Investigator Ets1 / Runx1 / 転写因子 / 転写制御 / リン酸化 / エンハンソソーム / CBFβ / 転写制御因子 / 化学修飾 / 転写制御機構 / 定量解析 / クライオ電子顕微鏡 / ヒストン修飾酵素 / ヌクレオソーム / 分子標的薬 / 医薬品探索 / 癌 / 創薬 / がん / LEF1 / TCR / X線結晶構造解析 / Nrf2 / Ｘ線結晶構造 / タンパク質 / 発現制御 / 分子動力学 / 細胞シグナル / Ｘ線結晶構造解析 / NMR / exon VII / phosphorylation / molecular fluctuations / enhanceosome / アロステリック / プロモーター / EBP / C / c-Myb / 転写制御因子高次複合体 / 揺らぎ / 磁気緩和時間測定 / 急性白血病 / 協調的DNA結合活性 / 構造的揺らぎ / 表面プラズモン共鳴 / 核磁気共鳴法 / MeCP2 / ヒストンシヤペロン / エンハンセオソーム / クロマチンリモデリング / ヒストンシャペロン / 連携研究者 / Ets1,Runx1,エンハンサー / タンパク質-核酸複合体 Less

ペプチド創薬に応用可能なペプチドプレニル基転移酵素群の構造生物学的解析Principal Investigator
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明Principal Investigator
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Study of the mechanism of nucleosome-enhanceosome conversion
- Principal Investigator
  
  OGATA Kazuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Yokohama City University
Search for anti-leukemic drugs targeting the cancer-related transcription factor Runx1/CBFbeta
- Principal Investigator
  
  Ogata Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Yokohama City University
Regulation mechanism of a transcription cycle by static/dynamic structural analyses
- Principal Investigator
  
  OGATA Kazuhiro
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Study for molecular mechanisms of chromatin remodeling factorsPrincipal Investigator
- Principal Investigator
  
  HAMADA Keisuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Mechanism for regulation of DECODE complexes in gene activation
- Principal Investigator
  
  OGATA Kazuhiro
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
膜結合型グルタチオンS-トランスフェラーゼの結晶構造解析Principal Investigator
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Study of molecular structural and dynamical aspects of transcriptional regulatory factors
- Principal Investigator
  
  OAGATA Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
3量体G蛋白質におけるGiαサブユニットの活性制御機構の構造学的研究Principal Investigator
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 転写制御とエピジェネティクス転写制御因子の分子構造と作用機構2008
- Author(s)
  緒方一博、浜田恵輔
- Total Pages
  16
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19770089
[Book] 転写制御とエピジェネティクス2008
- Author(s)
  緒方一博, 浜田恵輔
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17054033
[Book] 転写制御因子の分子構造と作用機構2008
- Author(s)
  緒方一博、浜田恵輔、南山堂
- Publisher
  転写制御とエピジェネティクス
- Data Source
  KAKENHI-PROJECT-19770089
[Book] 分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」タンパク質の立体構造解析を行うために-分子構造解析のためのタンパク質試料調整法2005
- Author(s)
  椎名政昭, 浜田恵輔, 緒方一博
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-17054033
[Book] 分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」タンパク質の立体構造解析を行うために-分子構造解析のためのタンパク質試料調整法.2005
- Author(s)
  椎名政昭, 浜田恵輔, 緒方一博
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-16370051
[Book] 分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」2005
- Author(s)
  椎名政昭, 浜田恵輔, 緒方一博
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration2023
- Author(s)
  Vetro Annalisa et al
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 110 Issue: 8 Pages: 1356-1376
- DOI
  10.1016/j.ajhg.2023.06.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15619, KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20K08236
[Journal Article] Three KINSSHIP syndrome patients with mosaic and germline AFF3 variants2023
- Author(s)
  Inoue Yuta、Tsuchida Naomi、Okamoto Nobuhiko、Shuichi Shimakawa、Ohashi Kei、Saitoh Shinji、Ogawa Atsushi、Hamada Keisuke、Sakamoto Masamune、Miyake Noriko、Hamanaka Kohei、Fujita Atsushi、Koshimizu Eriko、Miyatake Satoko、Mizuguchi Takeshi、Ogata Kazuhiro、Uchiyama Yuri、Matsumoto Naomichi
- Journal Title
  
  Clinical Genetics
  
  Volume: 103 Issue: 5 Pages: 590-595
- DOI
  10.1111/cge.14292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20K17936, KAKENHI-PROJECT-21K15907, KAKENHI-PROJECT-23K24308, KAKENHI-PROJECT-23K18278, KAKENHI-PROJECT-23K07229, KAKENHI-PROJECT-20H03646, KAKENHI-PROJECT-23K27520, KAKENHI-PROJECT-23K27568
[Journal Article] Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases2023
- Author(s)
  Zhang Yuchen、Hamada Keisuke、Satake Masayuki、Sengoku Toru、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 44 Pages: 23893-23898
- DOI
  10.1021/jacs.3c07373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-ORGANIZER-21H05158, KAKENHI-PLANNED-21H05161
[Journal Article] A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association2023
- Author(s)
  Seyama Rie、Nishikawa Masashi、Ogata Kazuhiro、Nagata Koh-ichi、Matsumoto Naomichi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 9789-9789
- DOI
  10.1038/s41598-023-36381-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19498, KAKENHI-PROJECT-23K18278, KAKENHI-PROJECT-23K14946, KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-23K07229, KAKENHI-PROJECT-23K27520, KAKENHI-PROJECT-23K27568
[Journal Article] Structural basis of transcription regulation by CNC family transcription factor, Nrf22022
- Author(s)
  Sengoku Toru、Shiina Masaaki、Suzuki Kae、Hamada Keisuke、Sato Ko、Uchiyama Akiko、Kobayashi Shunsuke、Oguni Asako、Itaya Hayato、Kasahara Kota、Moriwaki Hirotomo、Watanabe Chiduru、Honma Teruki、Okada Chikako、Baba Shiho、Ohta Tsutomu、Motohashi Hozumi、Yamamoto Masayuki、Ogata Kazuhiro
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 21 Pages: 12543-12557
- DOI
  10.1093/nar/gkac1102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PLANNED-21H05264, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-21H04799, KAKENHI-PLANNED-21H05161
[Journal Article] LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates2022
- Author(s)
  Zhang Yuchen、Hamada Keisuke、Nguyen Dinh Thanh、Inoue Sumika、Satake Masayuki、Kobayashi Shunsuke、Okada Chikako、Ogata Kazuhiro、Okada Masahiro、Sengoku Toru、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Nature Catalysis
  
  Volume: 5 Issue: 8 Pages: 682-693
- DOI
  10.1038/s41929-022-00822-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-21K19056, KAKENHI-PROJECT-20H05618, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-19H02842, KAKENHI-PLANNED-21H05161
[Journal Article] Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant2022
- Author(s)
  Hamanaka Kohei、Miyoshi Keita、Sun Jia-Hui、Hamada Keisuke、Komatsubara Takao、Saida Ken、Tsuchida Naomi、Uchiyama Yuri、Fujita Atsushi、Mizuguchi Takeshi、Gerard Benedicte、Bayat Allan、Rinaldi Berardo、Kato Mitsuhiro、Tohyama Jun、Ogata Kazuhiro、Shi Yun Stone、Saito Kuniaki、Miyatake Satoko、Matsumoto Naomichi
- Journal Title
  
  Human Genetics
  
  Volume: 141 Issue: 2 Pages: 283-293
- DOI
  10.1007/s00439-021-02416-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-20K17936
[Journal Article] De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors2022
- Author(s)
  Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Chang Jun Shi、Okada Chikako、Nishimura Hirotaka、Terasaka Naohiro、Goto Yuki、Ogata Kazuhiro、Sengoku Toru、Onaka Hiroyasu、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 44 Pages: 20332-20341
- DOI
  10.1021/jacs.2c07937
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20H05618, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-21H04712, KAKENHI-PROJECT-22KF0114, KAKENHI-PLANNED-21H05161
[Journal Article] Two families with TET3-related disorder showing neurodevelopmental delay with craniofacial dysmorphisms2021
- Author(s)
  Seyama Rie、Tsuchida Naomi、Okada Yasuyuki、Sakata Sonoko、Hamada Keisuke、Azuma Yoshiteru、Hamanaka Kohei、Fujita Atsushi、Koshimizu Eriko、Miyatake Satoko、Mizuguchi Takeshi、Makino Shintaro、Itakura Atsuo、Okada Satoshi、Okamoto Nobuhiko、Ogata Kazuhiro、Uchiyama Yuri、Matsumoto Naomichi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Issue: 3 Pages: 157-164
- DOI
  10.1038/s10038-021-00986-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-21K06051
[Journal Article] De novo ATP1A3 variants cause polymicrogyria2021
- Author(s)
  Miyatake Satoko、Kato Mitsuhiro、Kumamoto Takuma、Hirose Tomonori、他
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 13 Pages: 2368-2368
- DOI
  10.1126/sciadv.abd2368
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06893, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18K15677, KAKENHI-PUBLICLY-19H04795, KAKENHI-PLANNED-20H05777, KAKENHI-PROJECT-20H03641, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-19K16921, KAKENHI-PROJECT-19K08281, KAKENHI-PROJECT-20H03438, KAKENHI-ORGANIZER-21H05158, KAKENHI-PLANNED-21H05159, KAKENHI-PROJECT-19H03228, KAKENHI-PROJECT-20H03270, KAKENHI-PROJECT-21H02405, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-21K19356, KAKENHI-PROJECT-21K19413
[Journal Article] GRIN2D variants in three cases of developmental and epileptic encephalopathy2018
- Author(s)
  Tsuchida Naomi、Hamada Keisuke、Shiina Masaaki、Kato Mitsuhiro、Kobayashi Yu、Tohyama Jun、Kimura Kazue、Hoshino Kyoko、Ganesan Vigneswari、Teik Keng W.、Nakashima Mitsuko、Mitsuhashi Satomi、Mizuguchi Takeshi、Takata Atsushi、Miyake Noriko、Saitsu Hirotomo、Ogata Kazuhiro、Miyatake Satoko、Matsumoto Naomichi
- Journal Title
  
  Clinical Genetics
  
  Volume: 94 Issue: 6 Pages: 538-547
- DOI
  10.1111/cge.13454
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10080, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-16H03293, KAKENHI-PROJECT-16H05160, KAKENHI-PROJECT-16H06254, KAKENHI-PROJECT-17K15630
[Journal Article] A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions2015
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K
- Journal Title
  
  J Mol Biol
  
  Volume: 427(8) Issue: 8 Pages: 1655-1669
- DOI
  10.1016/j.jmb.2014.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26330331, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118005
[Journal Article] Crystallization of the Ets1-Runx1-CBFβ-DNA complex formed on the TCRα gene enhancer2014
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Baba S, Sato K, Ogata K
- Journal Title
  
  Acta Crystallogr F Struct Biol Commun
  
  Volume: 70 Issue: 10 Pages: 1380-1384
- DOI
  10.1107/s2053230x14018470
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118005, KAKENHI-PROJECT-26330331
[Journal Article] Rational approach to the synthesis, evaluation and 68Ga labeling of a novel 4-anilinoquinoline EGFR inhibitor as a new imaging agent that selectively targets the EGFR tyrosine kinase2010
- Author(s)
  Theeraladanon C, Takahashi N, Shiina M, Hamada K, Takada Y, Endo H, Tateishi U, Oka T, Ogata K, Inoue T
- Journal Title
  
  Cancer Biotherapy & Radiopharmaceuticals 25(4)
  
  Pages: 479-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay2010
- Author(s)
  Saitsu H, Tohyama J, Kumada T, Egawa K, Hamada K, Okada I, Mizuguchi T, Osaka H, Miyata R, Furukawa T, Haginoya K, Hoshino H, Goto T, Hachiya Y, Yamagata T, Saitoh S, Nagai T, Nishiyama K, Nishimura A, Miyake N, Komada M, Hayashi K, Hirai S, OgOgS, OggS, Oggg, Oga K, Kato M, Fukuda A, Matsumoto N
- Journal Title
  
  Am J Hum Genet 86(6)
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b2009
- Author(s)
  Yamashita K, Suzuki A, Satoh Y, Ide M, Amano Y, Masuda-Hirata M, Hayashi YK, Hamada K, Ogata K, Ohno S
- Journal Title
  
  Biochem.Biophys.Res.Commun. 391(1)
  
  Pages: 812-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy2008
- Author(s)
  Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N.
- Journal Title
  
  Nature Genetics 40
  
  Pages: 782-788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770089
[Journal Article] De novo mutations in the gene encoding STXBP1(MUNC18-1)cause early infantile epileptic encephalopathy2008
- Author(s)
  Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N
- Journal Title
  
  Nat Genet 40(6)
  
  Pages: 782-788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] Structural basis for recruitment of human flap endonuclease 1 to PCNA2005
- Author(s)
  Sakurai S, Kitano K, Yamaguchi H, Hamada K, Okada K, Fukuda K, Uchida M, Ohtsuka E, Morioka H, Hakoshima T
- Journal Title
  
  EMBO J. 24(4)
  
  Pages: 683-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay2005
- Author(s)
  Hamada K, Kato M, Shimizu T, Ihara K, Mizuno T, Hakoshima T
- Journal Title
  
  Genes Cells 10
  
  Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054033
[Journal Article] Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay.2005
- Author(s)
  Keisuke HAMADA
- Journal Title
  
  Genes to Cells 10・1
  
  Pages: 1-11
- Data Source
  KAKENHI-PROJECT-16770086
[Presentation] Structural basis for the recognition of the antioxidant response element by the Nrf2-MafG heterodimer2018
- Author(s)
  Sengoku T, Shiina M, Uchiyama A, Baba S, Okada C, Sato K, Hamada K, Ogata K
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] Structural basis for the recognition of the antioxidant response element by the Nrf2-MafG heterodimer.2018
- Author(s)
  Sengoku T, Shiina M, Uchiyama A, Baba S, Okada C, Sato K, Hamada K, Ogata K
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] パートナー転写因子存在下における Ets1のコンフォーメーション分布の変化と活性制御機構2017
- Author(s)
  内山晃子，椎名政昭，浜田恵輔，馬場しほ，岡田千佳子，鈴木香絵，佐藤光，緒方一博
- Organizer
  2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] 転写因子Ets1の天然変性領域のリン酸化によるDNA結合制御機構の速度論的解析2017
- Author(s)
  内山晃子, 椎名政昭, 浜田恵輔, 馬場しほ, 岡田千佳子, 鈴木香絵, 佐藤光, 緒方一博
- Organizer
  新学術領域研究「転写サイクル」冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] 転写因子Ets1の天然変性領域のリン酸化によるDNA結合制御機構の速度論的解析2017
- Author(s)
  椎名政昭, 笠原浩太, 肥後順一, 浜田恵輔, 馬場しほ, 内山晃子, 佐藤光, 岡田千佳子, 中村春木, 緒方一博
- Organizer
  新学術領域研究「転写サイクル」冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] パートナー転写因子存在下におけるEts1のコンフォーメーション分布の変化と活性制御機構2017
- Author(s)
  内山晃子, 椎名政昭, 浜田恵輔, 馬場しほ, 岡田千佳子, 鈴木香絵, 佐藤光, 緒方一博
- Organizer
  新学術領域研究「転写サイクル」冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] 転写因子 Nrf2による酸化ストレス応答配列 (ARE) の認識機構の解析2017
- Author(s)
  椎名政昭，鈴木香絵，内山晃子，浜田恵輔，馬場しほ，岡田千佳子，太田力，緒方一博
- Organizer
  2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] 分子構造に基づく転写因子Nrf2の抗酸化剤応答配列認識機構の解析2017
- Author(s)
  椎名政昭, 鈴木香絵, 浜田恵輔, 内山晃子, 岡田千佳子, 馬場しほ, 太田力, 緒方一博
- Organizer
  新学術領域研究「転写サイクル」冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] 分子構造に基づく転写因子Nrf2の抗酸化剤応答配列認識機構の解析2017
- Author(s)
  椎名政昭, 鈴木香絵, 浜田恵輔, 内山晃子, 岡田千佳子, 馬場しほ, 太田力, 緒方一博
- Organizer
  新学術領域研究「転写サイクル」冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] Molecular behavior of a higher-order complex of multiple transcription factors on enhancer site upon phosphorylation2016
- Author(s)
  Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
- Organizer
  6th International Conference on Structural Biology (Structural Biology 2016)
- Place of Presentation
  New Orleans (Hilton New Orleans Airport Hotel), USA
- Year and Date
  2016-08-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] 転写因子Ets1の天然変性領域のリン酸化によるDNA結合制御機構の速度論的解析2016
- Author(s)
  椎名政昭，笠原浩太，肥後順一，馬場しほ，内山晃子，岡田千佳子，浜田恵輔，佐藤光，中村春木，緒方一博
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Molecular mechanism for modulation of a multiple transcription factor complex formed on enhancer site up on phosphorylation2016
- Author(s)
  Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
- Organizer
  5th International Conference and Exhibition on Metabolomics
- Place of Presentation
  Hyatt Regency Osaka（大阪府大阪市）
- Year and Date
  2016-05-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] パートナー因子によるEts1のコンフォーメーション分布の変化と活性制御機構の解析2016
- Author(s)
  内山晃子，椎名政昭，浜田恵輔，馬場しほ，岡田千佳子，鈴木香絵，佐藤光，緒方一博
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] 分子構造に基づく転写因子Nuclear factor (erythroid-derived2)-like2(Nrf2)の抗酸化剤応答配列認識機構の解析2015
- Author(s)
  鈴木香絵，椎名政昭，浜田恵輔，石川涼平，金井達哉，豊後泰子，岡田千佳子，馬場しほ，鈴木隆史，太田　力，山本雅之，緒方一博
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Kinetic characterization of a DNA binding activity of the transcription factor Ets1 and its regulation by phosphorylation in an intrinsically disordered region2015
- Author(s)
  Shiina M, Kasahara K, Higo J, Baba S, Hamada K, Uchiyama A, Suzuki K, Sato K, Nakamura H, Ogata K
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Ets1とRunx1のエンハンサー上での立体的な位置関係と協調性2015
- Author(s)
  内山晃子，椎名政昭，浜田恵輔，豊後泰子，嶋村麻利子，緒方一博
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Cooperative Formation of a Multiple Transcription Factor Assembly on an Enhancer DNA and Its Regulation by Phosphorylation of a Transcription Factor via a Cell Signaling2013
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Ogata K
- Organizer
  HUPO 2013（12th Human Proteome Organization Annual World Congress）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Allosteric Regulation of a Multiple Transcription Factor Assembly on an Enhancer DNA2013
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Ko Sato K, Yamamoto M, Ogata K
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Crystal structural analysis of drosophila nucleosome assembly protein2013
- Author(s)
  Hamada K, Shiina M, Nakashima R, Saito M, Ito T, Ogata K
- Organizer
  4th International Symposium on Diffraction Structural Biology
- Place of Presentation
  名古屋市中小企業振興会館（愛知県名古屋市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] DNA-mediated allosteric regulation in a complex of multiple transcription factors with DNA2013
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Ogata K
- Organizer
  4th International Symposium on Diffraction Structural Biology
- Place of Presentation
  名古屋市中小企業振興会館（愛知県名古屋市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] The cooperative activity of Ets1 and Runx1 on various target gene enhancers and the effect of phosphorylation of Ets1 on the cooperation2013
- Author(s)
  Uchiyama A, Shiina M, Hamada K, Bungo T, Shimamura M, Ogata K
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Mechanisms of DNA recognition by the Nrf2-containing transcription factor heterodimer2013
- Author(s)
  Suzuki K, Shiina M, Hamada K, Bungo T, Baba S, Ohta T, Ogata K
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Structural analyses for the effects of Ets1 phosphorylation on Ets1-containing TF-DNA assemblies2013
- Author(s)
  Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Tahirov TH, Ogata K
- Organizer
  HUPO 2013（12th Human Proteome Organization Annual World Congress）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] 細胞内シグナルによるエンハンソソーム制御の分子機構ワークショップ:クロマチン遺伝子制御研究の現状と将来2010
- Author(s)
  椎名政昭, 浜田恵輔, 豊後泰子, 嶋村麻利子, 内山晃子, 馬場しほ, 佐藤光, 緒方一博
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Context-Dependent Regulation of the Ets1-containing Enhanceosome by Phosphorylation.2010
- Author(s)
  Shiina M, Hamada K, Uchiyama A, Shimamura M, Inoue-Bungo T, Baba S, Sato K, Ogata K
- Organizer
  Decode winter workshop 2010
- Place of Presentation
  Yuzawa
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Analysis of cooperative DNA binding activity between c-Ets1 and Runx1 on various DNA.2010
- Author(s)
  Uchiyama A, Shiina M, Hamada K, Bungo T, Shimamura M, Ogata K
- Organizer
  Decode winter workshop 2010
- Place of Presentation
  Yuzawa
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Analysis of cooperative DNA binding activity between c-Ets1 and Runx1 on various enhancers.2010
- Author(s)
  Uchiyama A, Shiina M, Hamada K, Bungo T, Shimamura M, Ogata K
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Context-dependent regulation of the Ets1-containing enhanceosome.2010
- Author(s)
  Shiina M, Hamada K, Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Ogata K
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] TCRαエンハンサーにおける転写制御因子複合体形成の制御機構解析2009
- Author(s)
  Shiina M, Hamada K, Bungo T, Shimamura M, Uchiyama A, Baba S, Ogata K
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] タンパク質結晶化と構造解析2008
- Author(s)
  浜田恵輔
- Organizer
  タンパク質精製ワークショップ
- Place of Presentation
  国立遺伝学研究所
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-19770089
[Presentation] 転写制御因子-核酸複合体の静的・動的分子構造と機能との相関2007
- Author(s)
  椎名政昭,浜田恵輔,佐藤光,緒方一博
- Organizer
  タンパク3000総合シンポジウム「タンパク3000の成果と今後のタンパク研究展望」
- Place of Presentation
  東京
- Year and Date
  2007-02-27
- Data Source
  KAKENHI-PROJECT-19770089
[Presentation] Structural basis for the diverse DNA sequence recognition by C/EBPαhomodimer.2006
- Author(s)
  Shiina M, Takata S, Tahirov TH, Hamada K, Bungo T, Ogata K
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Structural basis for the diverse DNA sequence recognition by C/EBPβhomodimer.2005
- Author(s)
  Shiina M, Takata S, Hamada K, Ogata K
- Organizer
  XX Congress of the International Union of Crystallography, Florence
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Molecular mechanism for the diverse DNA sequence recognition by C/EBPβhomodimer.2005
- Author(s)
  Shiina M, Tahir TH, Hamada K, Takata S, Ogata K
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-17054033
[Presentation] Regulation of DNA binding of Ets1 by phosphorylation in an intrinsic disordered region
- Author(s)
  椎名政昭，浜田恵輔，井上－豊後泰子，嶋村麻利子，馬場しほ，内山晃子，鈴木香絵，タヒロフタヒール，緒方一博
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（神奈川県・横浜市）
- Year and Date
  2014-06-25 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Orientation of Ets1 and Runx1 binding sites on enhancers and their cooperative regulation
- Author(s)
  Uchiyama A, Shiina M, Hamada K, Bungo T, Shimamura M, Ogata K
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Structure-based analysis for DNA recognition mechanism of the Nrf2-containing transcription factor heterodimer
- Author(s)
  Suzuki K, Shiina M, Hamada K, Bungo T, Okada C, Baba S, Ohta T, Ogata K
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] Kinetic characterization of a DNA binding activity of the transcription factor Ets1 and its regulation by phosphorylation at an intrinsically disordered region
- Author(s)
  Shiina M, Hamada K, Bungo-Inoue T, Shimamura M, Uchiyama A, Baba S, Sato K, Suzuki K, Yamamoto M, Ogata K
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PLANNED-24118005
[Presentation] ヒストンシャペロンNap1の構造解析
- Author(s)
  浜田恵輔，椎名政昭，中島理沙，斎藤　誠，伊藤　敬，緒方一博
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PLANNED-24118005

1. OGATA Kazuhiro (90260330)

# of Collaborated Projects: 6 results

# of Collaborated Products: 50 results
2. SHIINA Masaaki (30347299)

# of Collaborated Projects: 5 results

# of Collaborated Products: 41 results
3. 仙石徹 (60576312)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. SATO Ko (90300962)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. SATO Fumitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. HIROSE Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 宮武聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 永田浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hamada Keisuke 浜田 恵輔

HAMADA Keisuke 浜田 恵輔

Research Projects

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Co-Researchers

ペプチド創薬に応用可能なペプチドプレニル基転移酵素群の構造生物学的解析Principal Investigator

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トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明Principal Investigator

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Study of the mechanism of nucleosome-enhanceosome conversion

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Search for anti-leukemic drugs targeting the cancer-related transcription factor Runx1/CBFbeta

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Regulation mechanism of a transcription cycle by static/dynamic structural analyses

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Study for molecular mechanisms of chromatin remodeling factorsPrincipal Investigator

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Mechanism for regulation of DECODE complexes in gene activation

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膜結合型グルタチオンS-トランスフェラーゼの結晶構造解析Principal Investigator

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Study of molecular structural and dynamical aspects of transcriptional regulatory factors

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3量体G蛋白質におけるGiαサブユニットの活性制御機構の構造学的研究Principal Investigator

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[Book] 転写制御とエピジェネティクス転写制御因子の分子構造と作用機構2008

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[Book] 転写制御とエピジェネティクス2008

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[Book] 転写制御因子の分子構造と作用機構2008

Author(s)

Publisher

Data Source

[Book] 分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」タンパク質の立体構造解析を行うために-分子構造解析のためのタンパク質試料調整法2005

Author(s)

Hamada Keisuke 浜田恵輔

HAMADA Keisuke 浜田恵輔