KUNO Toshiya 久野壽也

… Alternative Names

久野壽也クノトシヤ

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Researcher Number	00345779
Other IDs
Affiliation (based on the past Project Information) *help	2017: 名古屋市立大学, 大学院医学研究科, 研究員 2016: 名古屋市立大学, 大学院医学研究科, 准教授 2013 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 准教授 2012: 岐阜大学, 医学(系)研究科(研究院), 准教授 2010: 岐阜大学, 大学院・医学系研究科, 腫瘍病理 2007 – 2009: 香川大学, 医学部, 准教授 2004: 岐阜大学, 大学院・医学研究科, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Respiratory organ internal medicine Except Principal Investigator Experimental pathology / Biological Sciences
Keywords	Principal Investigator リスク評価 / デオキシコール酸 / 胆道発癌 / 化学物質誘発 / ハムスター / マウス / 胆嚢がん / 胆管 / 胆嚢 / 化学発癌 … More / PPARαアゴニスト / 発がん / 高インシュリン血症 / 高脂血症 / 肥満 / 腫瘍 / 肺 / PPARα アゴニスト / carcinogenesis / hyperinsulinemia / hyperlipidemia / obese / neoplasms / lung / PPARalpha agonist … More Except Principal Investigator 経気管内投与 / ラット / 中期発がん性試験法 / 肝発がん / 腫瘍 / 発がんリスク / ナノサイズ微粒子 / 二酸化チタン / 酸化銅 / GST-P positive foci / 経静脈投与 / 強制胃内投与 / 気管内投与 / ラット肝中期発癌試験 / ナノサイズ粒子 / 大腸癌 / 前癌病変 / β-catenin / BCAC / paneth cell Less

Establishment of the biliary cancer risk assessment system using a deoxycholic acid-induced gallbladder carcinogenesis mouse model.Principal Investigator
- Principal Investigator
  
  Kuno Toshiya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Suppressive effects of PPARalpha agonist against pulmonary carcinogenesis in micePrincipal Investigator
- Principal Investigator
  
  KUNO Toshiya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya City University
  Gifu University
Carcinogenic risk assessment of nano-sized particles
- Principal Investigator
  
  IMAIDA Katsumi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kagawa University
パネート細胞の大腸および胃発癌に係わる意義に関する実験的研究
- Principal Investigator
  
  森秀樹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Preventive effects of fermented brown rice and rice bran against N-nitrosobis (2-oxopropyl) amine-induced pancreatic tumorigenesis in male hamsters.2015
- Author(s)
  Kuno T, Takahashi S, Tomita H, Hisamatsu K, Hara A, Hirata A, Kobayashi H, Mori H.
- Journal Title
  
  Oncology Letters
  
  Volume: 10 Issue: 6 Pages: 3377-3384
- DOI
  10.3892/ol.2015.3809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09048
[Journal Article] The Peroxisome Proliferator-Activated Receptor (PPAR) α Agonist Fenofibrate Suppresses Chemically Induced Lung Alveolar Proliferative Lesions in Male Obese Hyperlipidemic Mice2014
- Author(s)
  Toshiya Kuno, Kazuya Hata, Manabu Takamatsu, Akira Hara, Yoshinobu Hirose, Satoru Takahashi, Katsumi Imaida, Takuji Tanaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 15 Issue: 5 Pages: 9160-72
- DOI
  10.3390/ijms15059160
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591159, KAKENHI-PROJECT-221S0001
[Journal Article] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.2011
- Author(s)
  Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T, Imaida K.
- Journal Title
  
  Exp.Toxicol.Pathol. 63
  
  Pages: 181-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Molecular analysis of carcinogen induced rodent lung tumors-Invovement of microRNA expression and Kras or EGFR mutation.2010
- Author(s)
  Yamakawa K, Kuno T, Hashimoto N, Yokohira M, Suzuki S, Nakano Y, Saoo K, Imaida, K.
- Journal Title
  
  Molecular Medicine Reports 3
  
  Pages: 141-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Risk analysis of environmental chemicals on lung carcinogenesis.2010
- Author(s)
  Imaida K, Yokohira M, Hashimoto N, Kuno T.
- Journal Title
  
  Asian Pacific J Cancer Prev 11
  
  Pages: 9-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Tumorigenesis of 2-Amino-3,8-dimethylimidazo[4,5-f]qu inoxaline (MeIQx), but not enhancing effects of concomitant high fat diet, on lung carcinogenesis in female A/J mice.2010
- Author(s)
  Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Yokohira M, Zeng Y, Kuno T, Totsuka Y, Takahashi M, Wakabayashi K, Imaida K.
- Journal Title
  
  Oncol.Lett. 1
  
  Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.2010
- Author(s)
  Suzuki S, Yokohira M, Hashimoto N, Saoo K, Matsuda Y, Yamakawa K, Nakano Y, Kuno T, Imaida K.
- Journal Title
  
  Molecular Medicine Reports 3
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.2010
- Author(s)
  Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K.
- Journal Title
  
  Oncol.Lett. 1
  
  Pages: 273-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats.2009
- Author(s)
  Yokohira M, Kuno T, Yamakawa K, Hashimoto N, Ninomiya F, Suzuki S, Saoo K, Imaida K.
- Journal Title
  
  J.Toxicol.Pathol. 22
  
  Pages: 1-10
- NAID
  10030977104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.2009
- Author(s)
  Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K.
- Journal Title
  
  J.Toxicol.Pathol. 22
  
  Pages: 179-185
- NAID
  10030978156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats.2009
- Author(s)
  Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T, Imaida K. A lung
- Journal Title
  
  J.Toxicol.Pathol. 22
  
  Pages: 71-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats2009
- Author(s)
  Yokohira M, Kuno T, Imaida K, et al.
- Journal Title
  
  J.Toxicol.Pathol. 22
  
  Pages: 1-10
- NAID
  10030977104
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Lung toxicity of 16 fine particles on intratracheal instillation in a bioassay model using F344 male rats.2008
- Author(s)
  Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Hashimoto N, Suzuki S, Saoo K, Imaida K.
- Journal Title
  
  Toxicol.Pathol. 36
  
  Pages: 620-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.2008
- Author(s)
  Yokohira M, Takeuchi H, Saoo K, Matsuda Y, Yamakawa K, Hosokawa K, Kuno T, Imaida K.
- Journal Title
  
  Exp.Toxicol.Pathol. 60
  
  Pages: 469-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J emale ice.2008
- Author(s)
  Kuno T, Yokohira M, Matsuda Y, Suzuki S, Hashimoto N, Yamakawa K, Saoo K, Imaida K.
- Journal Title
  
  Oncol.Rep. 20(4)
  
  Pages: 767-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] CYP2A6 overexpression in human lung cancers corelates with a high malignant status2007
- Author(s)
  Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Imaida K
- Journal Title
  
  Oncol Rep. 18
  
  Pages: 53-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Overexpression of CYP2A6 in Human Colorectal Tumors2007
- Author(s)
  Matsuda Y, Saoo K, Yamakawa K, Yokohira M, Suzuki S, Kuno T, Kamataki T, Imaida K.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 1582-1585
- NAID
  10019997476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay2007
- Author(s)
  Imaida K, Yokohira Y, Kuno T
- Journal Title
  
  J.Toxicol.Pathol. 20
  
  Pages: 117-123
- NAID
  10025854280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Journal Article] Detection of carcinogenic and modifying potentials by test compounds using amouse lung carcinogenesis bioassay.2007
- Author(s)
  Imaida K, Yokohira Y, Kuno T.
- Journal Title
  
  J.Toxicol.Pathol. 20
  
  Pages: 117-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] マウス胆嚢におけるN-メチル-N-フォルミルヒドラジンの発がんイニシエーション作用と系統間における感受性の検討2017
- Author(s)
  久野壽也、早川将史、不二哲、内木綾、鈴木周五、高橋智
- Organizer
  第33回日本毒性病理学会総会及び学術集会
- Place of Presentation
  ビッグ・アイ（国際障害者交流センター）（大阪・堺）
- Year and Date
  2017-01-26
- Data Source
  KAKENHI-PROJECT-15K09048
[Presentation] N-メチル-N-フォルミルヒドラジンのマウス胆嚢発がんイニシエーション作用と系統間感受性の検討.2017
- Author(s)
  ①久野壽也, 早川将史, 内木綾, 鈴木周五, 山下依子, 高橋智.
- Organizer
  第106回日本病理学会総会.
- Data Source
  KAKENHI-PROJECT-15K09048
[Presentation] マウス胆嚢におけるN-メチル-N-フォルミルヒドラジンの発がんイニシエーション作用と系統間における感受性の検討.2017
- Author(s)
  ②久野壽也, 早川将史, 不二哲, 内木綾, 鈴木周五, 高橋智.
- Organizer
  第33回日本毒性病理学会学術集会.
- Data Source
  KAKENHI-PROJECT-15K09048
[Presentation] マウス胆嚢におけるN-メチル-N-フォルミルヒドラジンの発がんイニシエーション効果の検討2016
- Author(s)
  久野壽也、加藤寛之、内木綾、鈴木周五、高橋智
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K09048
[Presentation] 炎症関連TSODマウス大腸発癌に対するACE阻害薬enalaprilの修飾効果2013
- Author(s)
  久野壽也、田中卓二、三輪貴生、小川博史、遠藤奨、後藤滉平、原明
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  日本薬学会長井記念館（東京）
- Data Source
  KAKENHI-PROJECT-24591159
[Presentation] Fenofibrateの4NQO誘発肥満、高脂血症マウス肺増殖性病変に及ぼす影響2012
- Author(s)
  久野壽也、田中卓二、廣瀬善信、平田暁大、原明
- Organizer
  がん予防学会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24591159
[Presentation] A PPARa agonist, fenofibrate suppress 4NQO-induced pulmonary proliferative lesions in obese and hyperlipidemic mice.2012
- Author(s)
  Kuno T, Tanaka T, Takamatsu M, Hatano Y, Tomita H, Hirose Y, Hirata A, Hara A
- Organizer
  71th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591159
[Presentation] Potential of inhibitory effects by D-allose, a rare sugar, on liver carcinogenesis in a rat medium-term bioassay2007
- Author(s)
  Yamakawa K, Yokohira M, Kuno T, Matsuda Y, Hashimoto N, Hosokawa K, Saoo K, Imaida K.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] A study on the threshold for MeIQx carcinogenesis in lung using A/J mice2007
- Author(s)
  Suzuki S, Yokohira M, Kuno T, Yamakawa K, Hosokawa K, Matsuda Y, Shiooka T, Imaida, K.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] Modulation effect of NNK-induced lung tumor by CYP2A inhibitor,8-MOP administered during promotion or progression phase2007
- Author(s)
  Kuno T, Saoo K, Yokohira M, Yamakawa K, Hashimoto N, Hosokawa K. Matsuda Y. Imaida K
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] Short-term effect of various chemicals on NNK-induced tumorigenesis in A/J female mouse2007
- Author(s)
  Matsuda Y, Yamakawa K, Saoo K, Yokohira M, Hosokawa K, Kuno T, Naito Z, Imaida, K.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] Enzymatically modified isogercitrin and isoquercitorin, in a rat medium-term liver carcinogenesis bioassay2007
- Author(s)
  Hosokawa K, Yokohira M, Yamakawa K, Saoo K, Matsuda Y, Suzuki S, Kuno T, Imaida K.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393
[Presentation] Establishment of a bioassay for lung carcinogenesis due to fine particlesinstilled intratracheally in F344 rats2007
- Author(s)
  Yokohira M, Kuno T, Saoo K, Yamakawa K, Suzuki S, Hosokawa K, Matsuda Y, Kinouchi S, Imaida K
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19590393

1. HIROSE Yoshinobu (20293574)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. IMAIDA Katsumi (90160043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
3. YOKOHIRA Masanao (70403780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
4. HASHIMOTO Nozomi (60448371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. INOUE Tatsushi (80384593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森秀樹 (70021433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUNO Toshiya 久野 壽也

久野 壽也 クノ トシヤ

Research Projects

Research Products

Co-Researchers

Establishment of the biliary cancer risk assessment system using a deoxycholic acid-induced gallbladder carcinogenesis mouse model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppressive effects of PPARalpha agonist against pulmonary carcinogenesis in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Carcinogenic risk assessment of nano-sized particles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

パネート細胞の大腸および胃発癌に係わる意義に関する実験的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Preventive effects of fermented brown rice and rice bran against N-nitrosobis (2-oxopropyl) amine-induced pancreatic tumorigenesis in male hamsters.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Peroxisome Proliferator-Activated Receptor (PPAR) α Agonist Fenofibrate Suppresses Chemically Induced Lung Alveolar Proliferative Lesions in Male Obese Hyperlipidemic Mice2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.2011

Author(s)

Journal Title

Data Source

[Journal Article] Molecular analysis of carcinogen induced rodent lung tumors-Invovement of microRNA expression and Kras or EGFR mutation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Risk analysis of environmental chemicals on lung carcinogenesis.2010

Author(s)

Journal Title

Data Source

[Journal Article] Tumorigenesis of 2-Amino-3,8-dimethylimidazo[4,5-f]qu inoxaline (MeIQx), but not enhancing effects of concomitant high fat diet, on lung carcinogenesis in female A/J mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] carcinogenic bioassay of CuO and TiO2 nanoparticles with intratracheal instillation using F344 male rats.2009

Author(s)

Journal Title

Data Source

[Journal Article] An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in F344 rats2009

Author(s)

Journal Title

KUNO Toshiya 久野壽也

久野壽也クノトシヤ

[Presentation] マウス胆嚢におけるN-メチル-N-フォルミルヒドラジンの発がんイニシエーション作用と系統間における感受性の検討2017