HANAFUSA Hiroshi 花房洋

Researcher Number	00345844
Other IDs
Affiliation (Current)	2022: 名古屋大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 名古屋大学, 理学研究科, 准教授 2015: 名古屋大学, 理学(系)研究科(研究院), 准教授 2015: 名古屋大学, 大学院理学研究科, 准教授 2013 – 2014: 名古屋大学, 理学(系)研究科(研究院), 講師 2011 – 2012: 名古屋大学, 理学(系)研究科(研究院), 助教 … More 2011: 名古屋大学, 理学研究科, 助教 2008 – 2011: Nagoya University, 大学院・理学研究科, 助教 2007 – 2008: Nagoya University, 理学研究科, 助教 2006: 名古屋大学, 理学研究科, 助手 2003 – 2005: 名古屋大学, 大学院・理学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Cell biology / Molecular biology / Complex systems / Functional biochemistry / General medical chemistry / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Cell biology / Functional biochemistry
Keywords	Principal Investigator LRRK1 / EGFR / Sprouty / Xenopus / endosome / ERK / beta-catenin / チロシンリン酸化 / ネガティブフィードバック / アフリカツメガエル … More / サブトラクティブスクリーニング / Shp2 / Grb2 / Chordin / Organizer / ERK MAPキナーゼ / 中胚葉形成 / 背腹軸形成 / Nodal / MAPキナーゼ / Ras / 外胚葉 / Wntシグナル / 神経誘導 / Fos / FGFシグナル / シグナル伝達 / CLIP170 / Dynein / cilia / 中心体 / Rab7 / エンドソーム / membrane traffic / cDNAマイクロアレイ / 体軸形成 / マイクロインジェクション / negative feedback regulator / receptor tyrosine kinase signaling / dephosphorylation / Sos complex / 脱リン酸化 / マイクロアレイ / モルフォリノアンチセンスオリゴ / モルフォリノ / オーガナイザー / Xbra / 細胞増殖 / がん化 / EGF受容 / XGrhl3 / 上皮形成 / 転写因子 / ANR / BF1 / XRassf6 / MHB / XGrh13 / ESCRT / STAM1 / endocytosis / MVB / ILV / dynein / メンブレントラフィック / CLIP-170 / Dynactin / 細胞極性 / スピンドル配向 / 非対称分裂 / Spindle orientation / NuMA / RPE1細胞 / 一次シリア / NDE1 / 中心小体 / ライセンシングシグナル / 母娘中心小体 / セパレース / セパレースセンサー / centrosome / PLK1 / disassembly / cell cycle / シリア / NDEL1 / 細胞内トラフィック / オートファゴソーム / membrane contact site / endosomal traffic / rab7 / Mitophagy / Rab / LRRK2 … More Except Principal Investigator シグナル伝達 / 細胞内トラフィック / プロテインキナーゼ / モーター蛋白質 / LRRK1 / EGFR / endosome / endocytosis / EGF受容 / エンドサイトーシス / ダイニンモータ / ESCRT-0 / MVB sortin / EGF受容体 / MVB sorting / 遺伝学 / 神経科学 / 脳・神経 / 軸索再生 / 再生医学 Less

メンブレントラフィックによるEGFRシグナルの時空間制御Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya University
Regulation of membrane traffic by ROCO family kinase LRRK1/2Principal Investigator
- Principal Investigator
  
  Hanafusa Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Nagoya University
エンドソームを起点とするシグナル発信機構の解明Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya University
Analysis of the licensing mechanism of centriole duplication by using Separase SensorPrincipal Investigator
- Principal Investigator
  
  Hanafusa Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University
LRRK1による中心体複製及びシリアdisassembly制御機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Regulation of retrograde transport mediated by LRRK1-Dynein complexPrincipal Investigator
- Principal Investigator
  
  Hanafusa Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya University
LRRK１による中心体複製サイクル／シリア伸長制御機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Analysis of the regulation of asymmetric cell division by using the artificially induced polarization of HeLa cells.Principal Investigator
- Principal Investigator
  
  HANAFUSA Hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
Mechanism of signal transduction regulating axon regeneration
- Principal Investigator
  
  MATSUMOTO Kunihiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
ＬＲＲＫ１によるＥＧＦＲリソソーム分解経路選別機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Analysis of the spatiotemporal regulation of EGFR signal by LRRK1Principal Investigator
- Principal Investigator
  
  HIROSHI Hanafusa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University
ROCOファミリー分子LRRK1によるEGFR細胞内トラフィック制御機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Spatio-temporal regulation of cellular trafficking and signal transduction
- Principal Investigator
  
  MATSUMOTO Kunihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University
Analysis of the molecular mechanism how cells monitor the duration of ERK activityPrincipal Investigator
- Principal Investigator
  
  HANAFUSA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University
転写因子XGrhl3によるWntシグナル阻害メカニズムの解析と外胚葉分化Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
周辺制御因子によるRas/MAPキナーゼ経路の時空間的活性化機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
上皮形成を司る転写因子XGRHによるWntシグナル阻害メカニズムの解明Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
ERK活性化時間をモニターする細胞内分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Nagoya University
アフリカツメガエルをモデル系とした体軸形成に重要な遺伝子群の網羅的解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Xenopus初期胚におけるERK経路の活性化時間に応じた細胞運命決定機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
アフリカツメガエルをモデル系とした体軸形成に重要な遺伝子群の網羅的解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Ras/MAPキナーゼ経路の阻害因子Sproutyの活性制御機構の解析Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Xenopusをモデル動物としたSproutyによるネガティブフィードバック機構Principal Investigator
- Principal Investigator
  
  花房洋
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Nagoya University

[Book] Regulation of intracellular trafficking of the EGF receptor by ROCO family kinase LRRK1. Seikagaku 832011
- Author(s)
  Hanafusa H., Matsumoto K
- Data Source
  KAKENHI-PROJECT-23687030
[Journal Article] <i>Caenorhabditis elegans</i> F-Box Protein Promotes Axon Regeneration by Inducing Degradation of the Mad Transcription Factor2021
- Author(s)
  Shimizu Tatsuhiro、Pastuhov Strahil I.、Hanafusa Hiroshi、Sakai Yoshiki、Todoroki Yasuko、Hisamoto Naoki、Matsumoto Kunihiro
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Pages: 2373-2381
- DOI
  10.1523/jneurosci.1024-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16911, KAKENHI-PUBLICLY-19H04958, KAKENHI-PROJECT-19H00979, KAKENHI-PROJECT-18H02612
[Journal Article] CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner2021
- Author(s)
  Hisamoto N, Sakai Y, Ohta K, Shimizu T, Li C, Hanafusa H, Matsumoto K.
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Pages: 8309-8320
- DOI
  10.1523/jneurosci.0711-21.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04958, KAKENHI-PROJECT-18H02612
[Journal Article] BRCA1-BARD1 Regulates Axon Regeneration in Concert with the Gqα-DAG Signaling Network2021
- Author(s)
  Sakai Yoshiki、Hanafusa Hiroshi、Shimizu Tatsuhiro、Pastuhov Strahil I.、Hisamoto Naoki、Matsumoto Kunihiro
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Pages: 2842-2853
- DOI
  10.1523/jneurosci.1806-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16911, KAKENHI-PUBLICLY-19H04958, KAKENHI-PROJECT-19H00979, KAKENHI-PROJECT-18H02612
[Journal Article] The Integrin Signaling Network Promotes Axon Regeneration via the Src-Ephexin-RhoA GTPase Signaling Axis.2021
- Author(s)
  Sakai Yoshiki、Tsunekawa Mayuka、Ohta Kohei、Shimizu Tatsuhiro、Pastuhov Strahil Iv.、Hanafusa Hiroshi、Hisamoto Naoki、Matsumoto Kunihiro
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Pages: 4754-4767
- DOI
  10.1523/jneurosci.2456-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16911, KAKENHI-PUBLICLY-19H04958, KAKENHI-PROJECT-18H02612
[Journal Article] LRRK1 Phosphorylation of Rab7 at S72 Links Trafficking of EGFR-containing Endosomes to Its Effector RILP2019
- Author(s)
  Hanafusa Hiroshi、Yagi Takuya、Ikeda Haruka、Hisamoto Naoki、Nishioka Tomoki、Kaibuchi Kozo、Shirakabe Kyoko、Matsumoto Kunihiro
- Journal Title
  
  Journal of Cell Science
  
  Volume: 132
- DOI
  10.1242/jcs.228809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06911, KAKENHI-PUBLICLY-19H04958, KAKENHI-PUBLICLY-17H06001, KAKENHI-PROJECT-19H00979, KAKENHI-PROJECT-17H03544, KAKENHI-PROJECT-18H02612
[Journal Article] LRRK1 phosphorylation of Rab7 at Ser-72 links trafficking of EGFR-containing endosomes to its effector RILP2019
- Author(s)
  Hiroshi Hanafusa, Takuya Yagi, Haruka Ikeda, Naoki Hisamoto, Tomoki Nishioka, Kozo Kaibuchi, Kyoko Shirakabe, & Kunihiro Matsumoto
- Journal Title
  
  Journal of Cell Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04697
[Journal Article] C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways2019
- Author(s)
  Hisamoto Naoki、Shimizu Tatsuhiro、Asai Kazuma、Sakai Yoshiki、Pastuhov Strahil I.、Hanafusa Hiroshi、Matsumoto Kunihiro
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 39 Pages: 5662-5672
- DOI
  10.1523/jneurosci.2059-18.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16911, KAKENHI-PROJECT-15H02388, KAKENHI-PROJECT-19H00979, KAKENHI-PROJECT-17H03544, KAKENHI-PROJECT-18H02612
[Journal Article] TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor2019
- Author(s)
  Sakai Yoshiki、Hanafusa Hiroshi、Pastuhov Strahil Iv、Shimizu Tatsuhiro、Li Chun、Hisamoto Naoki、Matsumoto Kunihiro
- Journal Title
  
  EMBO reports
  
  Volume: 20
- DOI
  10.15252/embr.201847517
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16911, KAKENHI-PUBLICLY-19H04958, KAKENHI-PROJECT-15H02388, KAKENHI-PROJECT-19H00979, KAKENHI-PROJECT-17H03544, KAKENHI-PROJECT-18H02612
[Journal Article] Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration2018
- Author(s)
  Hisamoto, N., Tsuge, A., Pastuhov, S., Shimizu, T., Hanafusa, H., Matsumoto, K.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Pages: 3099-3099
- DOI
  10.1038/s41467-018-05478-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02388, KAKENHI-PUBLICLY-17H05501, KAKENHI-PROJECT-17H03544, KAKENHI-PROJECT-18H02612
[Journal Article] LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends.2015
- Author(s)
  Shin Kedashiro, Strahil I. Pastuhov, Tomoki Nishioka, Takashi Watanabe, Kozo Kaibuchi, Kunihiro Matsumoto, Hiroshi Hanafusa
- Journal Title
  
  J. Cell Sci.
  
  Volume: 128 Pages: 385-396
- DOI
  10.1242/jcs.161547
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-25113512, KAKENHI-PUBLICLY-25113513, KAKENHI-PUBLICLY-26112706, KAKENHI-PROJECT-15H04697
[Journal Article] PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.2015
- Author(s)
  Hanafusa H, Kedashiro S, Tezuka M, Funatsu M, Usami S, Toyoshima F, Matsumoto K
- Journal Title
  
  Nature Cell Biol.
  
  Volume: 17 Pages: 1024-1035
- DOI
  10.1038/ncb3204
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14508, KAKENHI-PUBLICLY-15H01208, KAKENHI-PUBLICLY-26112706
[Journal Article] LRRK1 regulates spindle orientation downstream of PLK1 by phosphorylating CDK5RAP2.2015
- Author(s)
  Hanafusa H, Matsumoto, K
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Pages: 3349-3350
- DOI
  10.1080/15384101.2015.1093446
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14508, KAKENHI-PUBLICLY-26112706
[Journal Article] Phosphorylation of CLIP-170 by LRRK1 regulates EGFR trafficking by promoting recruitment of p150Glued to MT plus-ends.2015
- Author(s)
  Kedashiro S, Pastuhov S, Nihioka T, Watanabe T, Kaibuchi K, Matsumoto, K, Hanafusa H
- Journal Title
  
  J. Cell Sci.
  
  Volume: 128 Pages: 385-396
- DOI
  10.1242/jcs.169102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14508
[Journal Article] EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR2012
- Author(s)
  Ishikawa, K., Nara, A., Matsumoto, K., Hanafusa, H.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 23 Pages: 1294-1306
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23113713
[Journal Article] EGFR-dependent phosphorylation of Leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR2012
- Author(s)
  Kouki Ishikawa, Atsuki Nara, Kunihiro Matsumoto, Hiroshi Hanafusa
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 7 Pages: 1294-1306
- DOI
  10.1091/mbc.e11-09-0780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J00883, KAKENHI-PROJECT-21247031, KAKENHI-PUBLICLY-22019015
[Journal Article] EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR2012
- Author(s)
  Ishikawa, K., Nara, A., Matsumoto K., and Hanafusa, H
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 23 Pages: 1294-1306
- Data Source
  KAKENHI-PROJECT-23687030
[Journal Article] EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR2012
- Author(s)
  Ishikawa, K., Nara, A., Matsumoto K., and Hanafusa, H.
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 23 Pages: 1294-1306
- Data Source
  KAKENHI-PROJECT-24657088
[Journal Article] Regulation of intracellular trafficking of the EGF receptor by ROCO family kinase LRRK12011
- Author(s)
  Hanafusa, H., Matsumoto, K
- Journal Title
  
  Seikagaku
  
  Volume: 83 Pages: 1127-1131
- NAID
  10030345984
- Data Source
  KAKENHI-PUBLICLY-23113713
[Journal Article] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.2011
- Author(s)
  Hanafusa, H., Ishikawa, K., Kedashiro, S., Saigo, K., lemura, S., Natsume, T., Komada, M., Shibuya, H., Nara, A., Matsumoto, K.
- Journal Title
  
  Nature Commun.
  
  Volume: 2 Pages: 158-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247031
[Journal Article] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor2011
- Author(s)
  Hanafusa, H., Ishikawa, K., Kedashiro, S.,以下省略
- Journal Title
  
  Nature Commun
  
  Volume: 2 Pages: 158-158
- Data Source
  KAKENHI-PROJECT-23687030
[Journal Article] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.2011
- Author(s)
  Hanafusa, H., Ishikawa, K., Kedashiro, S., Saigo, T., Iemura, S., Natsume, T., Komada, M., Shibuya, H., Nara, A., Matsumoto K.
- Journal Title
  
  Nature Communications
  
  Volume: 2 Pages: 158-158
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21113509
[Journal Article] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor2011
- Author(s)
  Hanafusa, H., Ishikawa, K., Kedashiro, S., Saigo, K., Iemura, S., 4 Natsume, T., Komada, M., Shibuya, H., Nara, A., and Matsumoto, K
- Journal Title
  
  Nature Commun
  
  Volume: 2 Pages: 158-158
- DOI
  10.1038/ncomms1161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247031, KAKENHI-PUBLICLY-22019015
[Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning2009
- Author(s)
  Hanafusa, H., Matsumoto, K., Nishida, E.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 106-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247031
[Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning.2009
- Author(s)
  Hanafusa, H., Matsumoto, K., and Nishida, E.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 106-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770167
[Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning2009
- Author(s)
  Hanafusa, H., Matsumoto, K., and Nishida, E
- Journal Title
  
  Nature Cell Biol
  
  Volume: 11 Pages: 106-109
- DOI
  10.1038/ncb1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247031
[Journal Article] Regulation of ERK activity duration by Sprouty contributes to dorsooventral patterning2009
- Author(s)
  Hiroshi Hanafusa, Kunihiro Matsumoto, Eisuke Nishida
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 106-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770167
[Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning.2009
- Author(s)
  Hanafusa, H., Matsumoto, K.*, Nishida, E.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 106-109
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21113509
[Journal Article] Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos.2008
- Author(s)
  Ishibashi, H., Matsumura, N., Hanafusa, H., Matsumoto, K., De Robertis, E.M., and Kuroda, H.
- Journal Title
  
  Mech. Dev. 125
  
  Pages: 58-66
- NAID
  120000796548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770167
[Journal Article] Shp2, an SH2-containing Protein-tyrosine Phosphatase, Positively Regulates Receptor Tyrosine Kinase Signaling by Dephosphorylating2004
- Author(s)
  花房洋, 鳥居暁, 安永隆之, 松本邦弘, 西田栄介
- Journal Title
  
  The journal of Biological Chemistry 279
  
  Pages: 22992-22995
- Data Source
  KAKENHI-PROJECT-16027222
[Journal Article] Shp2, an SH2-containing Protein-tyrosine Phosphatase, Positively Regulates Receptor Tyrosine Kinase Signaling by Dephosphorylating2004
- Author(s)
  花房洋, 鳥居暁, 安永隆之, 松本邦弘, 西田栄介
- Journal Title
  
  The journal of Biological Chemistry 279
  
  Pages: 22992-22995
- Data Source
  KAKENHI-PROJECT-15770109
[Presentation] 小胞体ーエンドソームコンタクトサイトにおける2019
- Author(s)
  花房洋
- Organizer
  蛋白質科学会・細胞生物学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02612
[Presentation] 小胞体ーエンドソームコンタクトサイトにおけるEGFR活性制御機構2019
- Author(s)
  花房洋
- Organizer
  蛋白質科学会・細胞生物学会合同年会
- Data Source
  KAKENHI-PUBLICLY-19H04958
[Presentation] LRRK1はRab7 Ser-72をリン酸化し、エフェクター分子RILPによるEGFR含有エンドソームの輸送を促進する2019
- Author(s)
  花房洋、八木拓也、西岡朋生、貝淵弘三、白壁恭子、松本邦弘
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-18H02612
[Presentation] LRRK1はRab7 Ser-72をリン酸化し、エフェクター分子RILPによるEGFR含有エンドソームの輸送を促進する2019
- Author(s)
  花房洋、八木拓也、西岡朋生、貝淵弘三、白壁恭子、松本邦弘
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PUBLICLY-19H04958
[Presentation] LRRK1によるエンドソームから発信されるEGFRシグナルの制御2018
- Author(s)
  花房洋
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-18H02612
[Presentation] LRRK1によるエンドソームから発信されるEGFRシグナルの制御2018
- Author(s)
  花房洋
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-15H04697
[Presentation] ROCO family kinase LRRK1 regulates the transport and maturation of EGFR-containing endosomes2018
- Author(s)
  花房洋
- Organizer
  Annual Congress of Molecular & Cell Biology-2018
- Data Source
  KAKENHI-PROJECT-15H04697
[Presentation] LRRK1による細胞内トラフィックを介したEGFRシグナル制御2017
- Author(s)
  花房洋
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-17H06001
[Presentation] LRRK1による細胞内トラフィックを介したEGFRシグナル制御2017
- Author(s)
  花房洋
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04697
[Presentation] ROCOファミリーキナーゼLRRK1によるシリア退縮制御2016
- Author(s)
  花房洋
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H04697
[Presentation] ROCO family kinase LRRK1 regulates the transport and maturation of autophagosomes through Rab7 phosphorylation2016
- Author(s)
  花房洋
- Organizer
  日本細胞生物学会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-15H04697
[Presentation] ROCOファミリーキナーゼLRRK1によるシリア退縮制御2016
- Author(s)
  花房洋
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01208
[Presentation] PLK1依存的に活性化したLRRK1はCDK5RAP2をリン酸化することでスピンドル配向を制御する2014
- Author(s)
  花房洋
- Organizer
  第３７回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25113512
[Presentation] The UNC-23–HSP-1 chaperone system determines localization of Parkinson disease-related kinase LRK-1 in C. elegans2014
- Author(s)
  Tanimul Alam, Takashi Fukuzono, Strahil Pastuhov, Okinobu Fukushima, Chun Li, Ayuna Hattori, Hiroshi Hanafusa, Kunihiro Matsumoto, Naoki Hisamoto
- Organizer
  Society for Neuroscience annual meeting 2014
- Place of Presentation
  Walter E. Washington Convention Center
- Year and Date
  2014-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24247025
[Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御2013
- Author(s)
  花房洋　慶田城迅　渡辺崇　貝淵弘三　松本邦弘
- Organizer
  日本細胞生物学会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御2013
- Author(s)
  花房洋　慶田城迅　渡辺崇　貝淵弘三　松本邦弘
- Organizer
  日本細胞生物学会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1 regulates the maturation of autolysosome by phosphorylating Rab72013
- Author(s)
  Haruka Ikeda, Hiroshi Hanafusa, Tomoki Nishioka, Kozo Kaibuchi, Kunihiro Matsumoto, Kyoko Shirakabe
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1 regulates EGFR intracellular trafficking by phosphorylating CLIP-1702013
- Author(s)
  Shin Kedashiro, Hiroshi Hanafusa, Takashi Watanabe, Kozo Kaibuchi, Kunihiro Matsumoto
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1 regulates EGFR intracellular tr0afficking by phosphorylating CLIP-1702013
- Author(s)
  Shin Kedashiro, Hiroshi Hanafusa, Takashi Watanabe, Kozo Kaibuchi, Kunihiro Matsumoto
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1 regulates the maturation of autolysosome by phosphorylating Rab72013
- Author(s)
  Haruka Ikeda, Hiroshi Hanafusa, Tomoki Nishioka, Kozo Kaibuchi, Kunihiro Matsumoto, Kyoko Shirakabe
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] The regulation of the intracellular trafficking of EGFR by ROCO family kinase LRRK12013
- Author(s)
  花房洋、慶田城迅、渡辺崇、貝淵弘三、松本邦弘
- Organizer
  第65回日本細胞生物学会年会
- Place of Presentation
  ウインク愛知
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御2013
- Author(s)
  花房洋　慶田城迅　渡辺崇　貝淵弘三　松本邦弘
- Organizer
  日本細胞生物学会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PUBLICLY-25113512
[Presentation] The regulation of the intracellular trafficking of EGFR by ROCO family kinase LRRK12013
- Author(s)
  花房洋、慶田城迅、渡辺崇、貝淵弘三、松本邦弘
- Organizer
  第65回日本細胞生物学会年会
- Place of Presentation
  ウインク愛知
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1はM期中心体のintegrity維持に必要である2012
- Author(s)
  小松日菜子、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1はCLIP170をリン酸化することによりEGFRの微小管上の輸送を制御する2012
- Author(s)
  慶田城迅、花房洋、高島成二、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1はaggregatesの輸送を介してaggresome形成を制御する2012
- Author(s)
  崔恵蘭、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] PLK1-LRRK1経路によるM期紡錘体配向の制御機構2012
- Author(s)
  花房洋、手塚基弘、豊島文子、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] PP5はLRRK1キナーゼ活性を負に制御することで紡錘体の多極化を防いでいる2012
- Author(s)
  佐井和人、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1はCLIP170をリン酸化することによりEGFRの微小管上の輸送を制御する2012
- Author(s)
  慶田城迅、花房洋、高島成二、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] EGFR依存的なLRRK1のリン酸化は適切なEGFR細胞内トラフィックに重要である2012
- Author(s)
  石川光紀、花房洋、奈良篤樹、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1はPrefoldin複合体と相互作用することで星状体微小管の形成に機能している2012
- Author(s)
  宇佐美学史、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1はキネトコアとスピンドル微小管との接着を安定化する2012
- Author(s)
  伊藤裕志、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1はaggregatesの輸送を介してaggresome形成を制御する2012
- Author(s)
  崔恵蘭、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] LRRK1はPrefoldin複合体と相互作用することで星状体微小管の形成に機能している2012
- Author(s)
  宇佐美学史、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] セリンスレオニンフォスファターゼPP5によるLRRK1キナーゼ活性の制御機構2012
- Author(s)
  佐井和人、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1はキネトコアとスピンドル微小管との接着を安定化する2012
- Author(s)
  伊藤裕志、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] PP5はLRRK1キナーゼ活性を負に制御することで紡錘体の多極化を防いでいる2012
- Author(s)
  佐井和人、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] EGFR依存的なLRRK1のリン酸化は適切なEGFR細胞内トラフィックに重要である2012
- Author(s)
  石川光紀、花房洋、奈良篤樹、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1はM期中心体のintegrity維持に必要である2012
- Author(s)
  小松日菜子、花房洋、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] セリンスレオニンフォスファターゼPP5によるLRRK1キナーゼ活性の制御機構2012
- Author(s)
  佐井和人、花房洋、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24657088
[Presentation] PLK1-LRRK1経路によるM期紡錘体配向の制御機構2012
- Author(s)
  花房洋、手塚基弘、豊島文子、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23687030
[Presentation] LRRK1 regulates endosomal trafficking of EGFR transport by phosphorylating CLIP-1702011
- Author(s)
  慶田城迅,高島成二,花房洋,松本邦弘
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道大学学術交流館
- Data Source
  KAKENHI-PROJECT-21247031
[Presentation] PLK1-LRRK1経路によるM期紡錘体配向の制御機構2011
- Author(s)
  花房洋
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-23113713
[Presentation] Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor2010
- Author(s)
  花房洋
- Organizer
  札幌国際がんシンポジウム2010
- Place of Presentation
  北海道大学学術交流会館
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PUBLICLY-21113509
[Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御2009
- Author(s)
  花房洋, 松本邦弘
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21247031
[Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御2009
- Author(s)
  花房洋
- Organizer
  生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PUBLICLY-21113509
[Presentation] LRRK 1はESCRT-O複合体と相互作用することでEGFR細胞内トラフィックを制御している2008
- Author(s)
  花房洋
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19770167
[Presentation] LRRK1はESCRT-0複合体と相互作用することでEGFR 細胞内トラフィックを制御している2008
- Author(s)
  花房洋
- Organizer
  分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19770167
[Presentation] LRRK1はGrb2を介したEGFRエンドサイトーシスを制御する2007
- Author(s)
  花房洋
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19770167
[Presentation] LRRK1 はGrb2 を介したEGFRエンドサイトーシスを制御する2007
- Author(s)
  花房洋
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19770167
[Presentation] PLK1-LRRK1経路によるM期紡錘体配向の制御機構
- Author(s)
  花房洋
- Organizer
  分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23687030

1. MATSUMOTO Kunihiro (70116375)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. HISAMOTO Naoki (80283456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TOMOKI Nishioka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. PASTUHOV STRAHIL

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 白壁恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 貝淵弘三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HANAFUSA Hiroshi 花房 洋

Research Projects

Research Products

Co-Researchers

メンブレントラフィックによるEGFRシグナルの時空間制御Principal Investigator

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Regulation of membrane traffic by ROCO family kinase LRRK1/2Principal Investigator

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エンドソームを起点とするシグナル発信機構の解明Principal Investigator

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Analysis of the licensing mechanism of centriole duplication by using Separase SensorPrincipal Investigator

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LRRK1による中心体複製及びシリアdisassembly制御機構の解析Principal Investigator

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Regulation of retrograde transport mediated by LRRK1-Dynein complexPrincipal Investigator

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LRRK１による中心体複製サイクル／シリア伸長制御機構の解析Principal Investigator

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Analysis of the regulation of asymmetric cell division by using the artificially induced polarization of HeLa cells.Principal Investigator

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Mechanism of signal transduction regulating axon regeneration

Principal Investigator

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ＬＲＲＫ１によるＥＧＦＲリソソーム分解経路選別機構の解析Principal Investigator

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Analysis of the spatiotemporal regulation of EGFR signal by LRRK1Principal Investigator

Principal Investigator

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ROCOファミリー分子LRRK1によるEGFR細胞内トラフィック制御機構の解析Principal Investigator

Principal Investigator

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Review Section

Research Institution

Spatio-temporal regulation of cellular trafficking and signal transduction

Principal Investigator

Project Period (FY)

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HANAFUSA Hiroshi 花房洋