TSUJI Naoki 辻直樹

Researcher Number	00347171
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2008: 札幌医科大学, 医学部, 講師 2003 – 2005: 札幌医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine Except Principal Investigator Gastroenterology / Digestive surgery / Laboratory medicine
Keywords	Principal Investigator HAMA / HETEROPHILIC BLOCKING REAGENT / ELISA FOR DETECTIONOF HAMA / ANTI-ANIMAL ANTIBODY / 異好性阻止薬 / HAMA検出用ELISA / 異好抗体 Except Principal Investigator Pancreas cancer / Human telomerase reverse transcriptase / 15-Deoxy-Δ^<12,14>-prostaglandin J_2 … More / preconditioning / PPAR γ-ligand / Prostaglandin J2 / Pancreas Cancer / human telomerase reverse transcriptase / PPARγ-ligand / PPAPγ-ligard / anti-apoptotic molecule / hepatic sinusoidal endothelial cell / apoptosis / ischemia-reperfusion injury / survivrn / survivin / 虚血再灌流障害 / 抗アポトーシス分子 / 肝類洞壁細胞 / アポトーシス / 虚血再灌流傷害 / Survivin / Immuno-PCR法 / 抗体検出アレイ / 癌診断 / 抗IAP抗体 / 臨床検査医学 Less

Development of auto-IAP-antibody screening array for diagnosing cancer patients
- Principal Investigator
  
  WATANABE Naoki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Sapporo Medical University
Deve lopment of assay systems for detection anti-mouse antibodyPrincipal Investigator
- Principal Investigator
  
  TSUJI Naoki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Sapporo Medical University
Development of new therapy for pancreas cancer using PPAR γ-ligand targeting hTERT.
- Principal Investigator
  
  WATANABE Naoki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Prevention of ischemic-reperfusion injury during operation by induction of TAP (inhibitor of apoptosis)
- Principal Investigator
  
  YAGIHASHI Atsuhito
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University School of Medicine

All 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression2009
- Author(s)
  Furuya M, Tsuji N, Kobayashi D, Watanabe N.
- Journal Title
  
  Int J Oncol 34
  
  Pages: 1061-1068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells2008
- Author(s)
  Moriai R, Tsuji N, Moriai M, Kobayashi D, Watanabe N.
- Journal Title
  
  Breast Cancer Research Treat (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells2007
- Author(s)
  Kobayashi, D., Koshida, S., Moriai, R., Tsuji, N., Watanabe, N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 334-340
- NAID
  10019481482
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer2007
- Author(s)
  Kaneko, R., Tsuji, N., Asanuma, K., Tanabe, H., Kobayashi, D., Watanabe, N
- Journal Title
  
  J Biol Chem 282
  
  Pages: 19273-19281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers2007
- Author(s)
  Amachika, T., Kobayashi, D., Moriai, R., Tsuji, N., Watanabe, N
- Journal Title
  
  Lung Cancer 56
  
  Pages: 337-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer2007
- Author(s)
  Kaneko R, Tsuji N, Asanuma K, Tanabe H, Kobayashi D, Watanabe N.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 19273-19281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] Inhibition of estrogen receptor β-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ ^<12, 14>-prostaglandin J2-induced apoptosis in cancer cells2007
- Author(s)
  Kondo K, Tsuji N, Asanuma K, Kobayashi D, Watanabe N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 3486-3496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] 15-Deoxy-Delta (12, 14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression2007
- Author(s)
  Kamagata C, Tsuji N, Moriai M, Kobayashi D, Watanabe N.
- Journal Title
  
  Breast Cancer Res Treat 102
  
  Pages: 263-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] In hibition of estrogen receptor β -mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ12, 14-prostaglandin J2-induced apoptosis in cancer cells2007
- Author(s)
  Kondo, K., Tsuji, N., Asanuma, K., Kobayashi, D., Watanabe, N
- Journal Title
  
  Exp Cell Res 313
  
  Pages: 3486-3496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells2007
- Author(s)
  Kobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N.
- Journal Title
  
  Cancer Sci 98
  
  Pages: 334-340
- NAID
  10019481482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] Specific overexpression of OLFM4GW112/hGC-1 mRNA in colon, breast, and lung cancer tissues detected using quantitative analysis2007
- Author(s)
  Koshida, S., Kobayashi, D., Moriai, R., Tsuji, N., Watanabe, N
- Journal Title
  
  Cancer Sci 98
  
  Pages: 315-320
- NAID
  10019481399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] 15-Deoxy-Delta(12,14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression2007
- Author(s)
  Kamagata, C., Tsuji, N., Moriai, M., Kobayashi, D., Watanabe, N
- Journal Title
  
  Breast Cancer Res Treat 102
  
  Pages: 263-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Specific overepression of OLFM4GW112/hGC-1 mRNA in colon, breast, and lung cancer tissues detected using quantitative analysis2007
- Author(s)
  Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N.
- Journal Title
  
  Cancer Sci 98
  
  Pages: 315-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390174
[Journal Article] Diagnostic relevance of overexpressed NOK mRNA in breast cancer2006
- Author(s)
  Moriai, R., Kobayashi, D., Amachika, T., Tsuji, N., Watanabe, N
- Journal Title
  
  Anticancer Res 26
  
  Pages: 4969-4974
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Journal Article] Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity.2005
- Author(s)
  Furuya D, Tsuji N, Yagihashi A, Watanabe N.
- Journal Title
  
  Exp Cell Res 307
  
  Pages: 26-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590611
[Journal Article] Introduction of a survivin gene-specific small inhibitory RNA inhibits growth of pancreatic cancer cells.2005
- Author(s)
  Tsuji N, Asanuma K, Kobayashi D, Yagihashi A, Watanabe N.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 3967-3972
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590611
[Journal Article] Survivin enhances telomerase activity via up-regulation of specificity protein 1-and c-Myc-mediated human telomerase reverse transcriptase gene transcription.2005
- Author(s)
  Endoh T, Tsuji N, Asanuma K, Yagihashi A, Watanabe N.
- Journal Title
  
  Exp Cell Res 305
  
  Pages: 300-311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590611
[Journal Article] Introduction of a survivin gene-specific small inhibitory RNA inhibits growth of pancreatic cancer cells.2005
- Author(s)
  Tsuji N et al.
- Journal Title
  
  Anticancer Res. 25
  
  Pages: 3967-3972
- Data Source
  KAKENHI-PROJECT-16590611
[Journal Article] Introduction of a survivin gene-specific small inhigitry RNA inhibits growth of pancreatic cancer cells.2005
- Author(s)
  Tsuji N, et al.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 3967-3972
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590611
[Journal Article] Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells.2004
- Author(s)
  Asanuma K, Tsuji N, Endoh T, Yagihashi A, Watanabe N.
- Journal Title
  
  J Immunol 172
  
  Pages: 3922-3929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590611
[Presentation] 乳癌組織におけるBmi-1遺伝子の発現量解析2008
- Author(s)
  佐伯理知, 小林大介, 辻直樹, 渡邉直樹
- Organizer
  第48回日本臨床化学会年次学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 乳癌および肺癌診断におけるチロシンキナーゼSTYK1解析の意義2008
- Author(s)
  小林大介, 盛合亮介, 辻直樹, 渡邉直樹
- Organizer
  第48回日本臨床化学会年次学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] ES細胞複製分子Nanogを用いた早期肺癌診断法の開発2008
- Author(s)
  韮澤慎也, 小林大介, 辻直樹, 渡邉直樹
- Organizer
  第48回日本臨床化学会年次学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 癌研究の新しい知見と臨床検査へのインパクト-分担-抗アポトーシス分子Survivinの機能解析と癌診断・治療への応用2007
- Author(s)
  辻直樹、渡辺直樹
- Organizer
  第54回日本臨床検査医学会学術集会
- Place of Presentation
  大阪府大阪市グランキューブ大阪
- Year and Date
  2007-11-23
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 癌研究の新しい知見と臨床検査へのインパクト-分担-抗アポトーシス分子Survivinの機能解析と癌診断・治療への応用2007
- Author(s)
  辻直樹
- Organizer
  第54回日本臨床検査医学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-11-23
- Data Source
  KAKENHI-PROJECT-18590534
[Presentation] 15d-PFJ2はhTERTの発現抑制を介して癌細胞にアポトーシスを誘導する2007
- Author(s)
  辻直樹, 小林大介, 渡邉直樹
- Organizer
  第20回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 癌研究の新しい知見と臨床検査へのインパクト-分担-抗アペトーシス分子Survivinの機能解析と癌診断・治療への応用2007
- Author(s)
  辻直樹
- Organizer
  第54回日本臨床検査医学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-11-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Presentation] 消化器癌分子標的治療の基礎と臨床-分担-HMG-CoA reductase阻害剤によるSurvivinを標的とした新たな癌治療法2007
- Author(s)
  辻直樹、渡辺直樹
- Organizer
  第18回日本消化器癌発生学会総会
- Place of Presentation
  北海道札幌市ウェルシティ札幌
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] Symposium "Update knowledge of cancer research and impact on clinical laboratory. Functional analysis of anti-apoptosis molecule Survivin and application for cancer diagnosis and treatment2007
- Author(s)
  Tsuji, N., Watanabe, N
- Organizer
  The 54th annual congress of Japanese Society of Laboratory Medicine
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Presentation] 抗アポトーシス分子SurvivinはhTERTの発現増強を介して癌細胞を不死化する2006
- Author(s)
  辻直樹, 小林大介, 渡邉直樹
- Organizer
  第65回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] HMG-CoA reductase阻害剤による癌細胞増殖抑制機序-FFPとGGGPがSurvivinの発現に及ぼす影響2006
- Author(s)
  辻直樹, 金子礼子, 浅沼康一, 渡邉直樹
- Organizer
  第46回日本臨床化学年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 15-deoxy-Δ ^<12, 14>-prostaglandin J_2はERのリン酸化阻害を介してhTERTの発現を抑制する2006
- Author(s)
  浅沼康一, 辻直樹, 盛合美加子, 渡邉直樹
- Organizer
  第46回日本臨床化学年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 新規チロシンキナーゼNOKは乳癌の早期診断に有用である2006
- Author(s)
  小林大介, 辻直樹, 渡邉直樹
- Organizer
  第65回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] 抗アポトーシス分子OLFM4は膵癌細胞で抗発現し増殖を促進する2006
- Author(s)
  小林大介, 辻直樹, 渡邉直樹
- Organizer
  第37回日本膵臓学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390174
[Presentation] Symposium "How far do we know the molecular function of tumor marker? Molecular function of anti-apoptosis molecule Survivin"2006
- Author(s)
  Tsuji, N., Watanabe, N
- Organizer
  The 38th annual congress of The Japan Society for Clinical Laboratory Automation
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Presentation] 腫瘍マーカーの分子機能はどこまで解っているのか-分担-抗アポトーシス分子Survivinの分子機能2006
- Author(s)
  辻直樹
- Organizer
  日本臨床検査自動化学会第38回大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2006-10-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590534
[Presentation] HMG-CoAreductase阻害剤によるSurvivinを標的とした新たな癌治療法2006
- Author(s)
  辻直樹, 小林大介, 渡邉直樹
- Organizer
  第19回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18390174

1. WATANABE Naoki (10158644)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
2. KOBAYASHI Daisuke (50295359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. YAGIHASHI Atsuhito (40260757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUJI Naoki 辻 直樹

Research Projects

Research Products

Co-Researchers

Development of auto-IAP-antibody screening array for diagnosing cancer patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Deve lopment of assay systems for detection anti-mouse antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapy for pancreas cancer using PPAR γ-ligand targeting hTERT.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of ischemic-reperfusion injury during operation by induction of TAP (inhibitor of apoptosis)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression2009

Author(s)

Journal Title

Data Source

[Journal Article] Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer2007

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of estrogen receptor β-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ ^<12, 14>-prostaglandin J2-induced apoptosis in cancer cells2007

Author(s)

Journal Title

Data Source

[Journal Article] 15-Deoxy-Delta (12, 14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression2007

Author(s)

Journal Title

Data Source

[Journal Article] In hibition of estrogen receptor β -mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ12, 14-prostaglandin J2-induced apoptosis in cancer cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Specific overexpression of OLFM4GW112/hGC-1 mRNA in colon, breast, and lung cancer tissues detected using quantitative analysis2007

Author(s)

Journal Title

NAID

Description

Data Source

TSUJI Naoki 辻直樹