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Nagao Motoshi  長尾 元史

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NAGAO Motoshi  長尾 元史

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Researcher Number 00359671
Other IDs
Affiliation (Current) 2025: 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究部長
Affiliation (based on the past Project Information) *help 2018 – 2025: 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究部長
2013 – 2017: 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究室長
2012: 東京大学, 分子細胞生物学研究所, 助教
2011: 東京大学, 分子細胞生物学研究所, 特任研究員
Review Section/Research Field
Principal Investigator
Basic Section 59010:Rehabilitation science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences
Except Principal Investigator
Rehabilitation science/Welfare engineering
Keywords
Principal Investigator
アストロサイト / リハビリテーション / 脳卒中 / グリア細胞 / 神経幹細胞 / グリア / ニューロン / エピゲノム / エピジェネティック因子 / 反応性アストログリオーシス … More / 反応性アストロサイト / トランスクリプトーム / 運動機能回復 / 大脳新皮質 / 転写因子 / クロマチン / グリア分化 / 幹細胞 / 神経発生 … More
Except Principal Investigator
グリア細胞 / 部分免荷式歩行 / 部分免荷歩行 / 運動学習 / カプリゾンモデル / カプリゾン / 前駆細胞 / オリゴデンドロサイト / エピジェネティクス / 再髄鞘化 Less
  • Research Projects

    (10 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (7 People)
  •  アストロサイトリジュベネーションによる脳卒中後のリハビリテーション促進法の開発Principal Investigator

    • Principal Investigator
      長尾 元史
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  エピゲノム操作を介したニューロン若返りによる脳卒中後のリハビリ促進法の開発Principal Investigator

    • Principal Investigator
      長尾 元史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Development of a treatment for chronic stroke by converting reactive astrocytes into astrocytes in the critical period.Principal Investigator

    • Principal Investigator
      Nagao Motoshi
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  脳卒中後のリハレスポンダー増加のための反応性アストログリオーシス制御に関する研究Principal Investigator

    • Principal Investigator
      長尾 元史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Elucidation of mechanisms of motor function recovery after rehabilitation using glial transcriptome analysis.Principal Investigator

    • Principal Investigator
      Nagao Motoshi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  The long term effect of rehabilitation effects on spastic symptoms

    • Principal Investigator
      Ogata Toru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Rehabilitation science/Welfare engineering
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Identification and characterization of a new regulator of astrocyte differentiationPrincipal Investigator

    • Principal Investigator
      Nagao Motoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Molecular mechanisms of the remyelination in chronic phase of spinal cord injury

    • Principal Investigator
      OGATA TORU
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Rehabilitation science/Welfare engineering
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Identification and characterization of novel factors that promote astrocyte differentiation of neural precursor cellsPrincipal Investigator

    • Principal Investigator
      NAGAO Motoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
      The University of Tokyo
  •  アストロサイトの分化制御と多様性を生み出す分子メカニズムPrincipal Investigator

    • Principal Investigator
      長尾 元史
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2017 2016 2015 2014 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation2017

    • Author(s)
      Ichihara Y, Doi T, Ryu Y, Nagao M, Sawada Y, Ogata T
    • Journal Title

      J Cell Physiol

      Volume: 232 Issue: 5 Pages: 986-995

    • DOI

      10.1002/jcp.25690

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H03048, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-26282159
  • [Journal Article] Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury2017

    • Author(s)
      Doi T, Ogata T, Yamauchi J, Sawada Y, Tanaka S, Nagao M
    • Journal Title

      J Neurosci

      Volume: 37(43) Issue: 43 Pages: 10290-10309

    • DOI

      10.1523/jneurosci.1109-17.2017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H01820, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-15K06792
  • [Journal Article] The crucial role of Erk2 in demyelinating inflammation in the central nervous system.2016

    • Author(s)
      Okazaki R, Doi T, Hayakawa K, Morioka K, Imamura O, Takishima K, Hamanoue M, Sawada Y, Nagao M, Tanaka S, Ogata T
    • Journal Title

      J Neuroinflammation

      Volume: 13 Issue: 1 Pages: 235-239

    • DOI

      10.1186/s12974-016-0690-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26282159, KAKENHI-PROJECT-15K06792
  • [Journal Article] Zbtb20 promotes astrocytogenesis during neocortical development2016

    • Author(s)
      Nagao, M., Ogata, T., Sawada, Y., Gotoh, Y.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11102-11102

    • DOI

      10.1038/ncomms11102

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06792, KAKENHI-PLANNED-22123003, KAKENHI-PROJECT-15H01820, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-26560410, KAKENHI-PROJECT-15H05773
  • [Journal Article] HMGN family proteins promote astrocyte differentiation of neural precursor cells.2014

    • Author(s)
      Nagao.M., Lanjakornsiripan,D.,Itoh Y., Kishi Y., Ogata T., and Gotoh Y.
    • Journal Title

      Stem Cells

      Volume: 32 Issue: 11 Pages: 2983-2997

    • DOI

      10.1002/stem.1787

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22123003, KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-25118706, KAKENHI-PROJECT-25840003
  • [Journal Article] Knockdown of Dock7 in vivo specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness.2012

    • Author(s)
      鳥居知宏ら
    • Journal Title

      American Journal of Molecular Biology

      Volume: 2 Issue: 03 Pages: 210-215

    • DOI

      10.4236/ajmb.2012.23021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300123, KAKENHI-PROJECT-23650200, KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-23123502
  • [Journal Article] Paxillin is the target of c-Jun N-terminal kinase in Schwann cells and regulates migration2012

    • Author(s)
      Miyamoto Y, Torii T, Yamamori N, Eguchi T, Nagao M, Nakamura K, Tanoue A, Yamauchi J.
    • Journal Title

      Cell Signal

      Volume: 24 Issue: 11 Pages: 2061-2069

    • DOI

      10.1016/j.cellsig.2012.06.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-23123502
  • [Journal Article] Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation2011

    • Author(s)
      Pei Z, Wang B, Chen G, Nagao M, Nakafuku M Campbell K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 4 Pages: 1675-1680

    • DOI

      10.1073/pnas.1008824108

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23123502
  • [Presentation] クロマチンリモデリング因子Chd7による脳卒中後の反応性アストログリオーシス制御2024

    • Author(s)
      長尾元史
    • Organizer
      日本ミエリン研究会
    • Data Source
      KAKENHI-PROJECT-23K24719
  • [Presentation] 脳卒中後の反応性アストログリオーシスにおけるクロマチンリモデリング因子Chd7の役割2023

    • Author(s)
      長尾元史
    • Organizer
      日本ミエリン研究会
    • Data Source
      KAKENHI-PROJECT-23K24719
  • [Presentation] クロマチンリモデリング因子Chd7による脳卒中後の反応性アストログリオーシス制御2023

    • Author(s)
      長尾元史
    • Organizer
      日本神経科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24719
  • [Presentation] 反応性アストロサイトにおけるクロマチンリモデリング因子Chd7の役割2022

    • Author(s)
      長尾元史
    • Organizer
      第6回日本ミエリン研究会
    • Data Source
      KAKENHI-PROJECT-18H03139
  • [Presentation] Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury.2017

    • Author(s)
      Doi T, Ogata T, Sawada Y, Tanaka S, Nagao M.
    • Organizer
      Neuroscience2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06792
  • [Presentation] Regulation of astrocyte production in the developing mouse neocortex.2017

    • Author(s)
      Lanjakornsiripan D, Furutachi S, Pior B-J, Kishi Y, Hirabayashi Y, Nagao M, Gotoh Y.
    • Organizer
      XIII European Meeting on Glial Cells in Health and Disease
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06792
  • [Presentation] アストロサイト分化を制御する新しい転写因子2015

    • Author(s)
      長尾元史
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K06792
  • [Presentation] HMGN family proteins promote astrocyte differentiation of neural precursor cells

    • Author(s)
      Nagao M, Lanjakornsiripan D, Itoh Y, Kishi Y, Gotoh Y, Ogata T
    • Organizer
      北米神経科学会(Neuroscience2014)
    • Place of Presentation
      ワシントンDC (アメリカ合衆国)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-24500437
  • 1.  OGATA TORU (00392192)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  杉森 道也 (20464026)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  鶴田 文憲 (30571450)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  岸 雄介 (00645236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  藤田 幸 (60631215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  後藤 由季子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  澤田 泰宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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