Nagao Motoshi 長尾元史

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NAGAO Motoshi 長尾元史

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Researcher Number	00359671
Other IDs
Affiliation (Current)	2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究部長
Affiliation (based on the past Project Information) *help	2018 – 2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究部長 2013 – 2017: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究室長 2012: 東京大学, 分子細胞生物学研究所, 助教 2011: 東京大学, 分子細胞生物学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences Except Principal Investigator Rehabilitation science/Welfare engineering
Keywords	Principal Investigator アストロサイト / リハビリテーション / 脳卒中 / グリア細胞 / 神経幹細胞 / グリア / リジュベネーション / ニューロン / エピゲノム / エピジェネティック因子 … More / 反応性アストログリオーシス / 反応性アストロサイト / トランスクリプトーム / 運動機能回復 / 大脳新皮質 / 転写因子 / クロマチン / グリア分化 / 幹細胞 / 神経発生 … More Except Principal Investigator グリア細胞 / 部分免荷式歩行 / 部分免荷歩行 / 運動学習 / カプリゾンモデル / カプリゾン / 前駆細胞 / オリゴデンドロサイト / エピジェネティクス / 再髄鞘化 Less

アストロサイトリジュベネーションによる脳卒中後のリハビリテーション促進法の開発Principal Investigator
- Principal Investigator
  
  長尾元史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
エピゲノム操作を介したニューロン若返りによる脳卒中後のリハビリ促進法の開発Principal Investigator
- Principal Investigator
  
  長尾元史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Development of a treatment for chronic stroke by converting reactive astrocytes into astrocytes in the critical period.Principal Investigator
- Principal Investigator
  
  Nagao Motoshi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
脳卒中後のリハレスポンダー増加のための反応性アストログリオーシス制御に関する研究Principal Investigator
- Principal Investigator
  
  長尾元史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Elucidation of mechanisms of motor function recovery after rehabilitation using glial transcriptome analysis.Principal Investigator
- Principal Investigator
  
  Nagao Motoshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
The long term effect of rehabilitation effects on spastic symptoms
- Principal Investigator
  
  Ogata Toru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Identification and characterization of a new regulator of astrocyte differentiationPrincipal Investigator
- Principal Investigator
  
  Nagao Motoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Molecular mechanisms of the remyelination in chronic phase of spinal cord injury
- Principal Investigator
  
  OGATA TORU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Identification and characterization of novel factors that promote astrocyte differentiation of neural precursor cellsPrincipal Investigator
- Principal Investigator
  
  NAGAO Motoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
  The University of Tokyo
アストロサイトの分化制御と多様性を生み出す分子メカニズムPrincipal Investigator
- Principal Investigator
  
  長尾元史
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2017 2016 2015 2014 2012 2011 Other

All Journal Article Presentation

[Journal Article] Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation2017
- Author(s)
  Ichihara Y, Doi T, Ryu Y, Nagao M, Sawada Y, Ogata T
- Journal Title
  
  J Cell Physiol
  
  Volume: 232 Issue: 5 Pages: 986-995
- DOI
  10.1002/jcp.25690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03048, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-26282159
[Journal Article] Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury2017
- Author(s)
  Doi T, Ogata T, Yamauchi J, Sawada Y, Tanaka S, Nagao M
- Journal Title
  
  J Neurosci
  
  Volume: 37(43) Issue: 43 Pages: 10290-10309
- DOI
  10.1523/jneurosci.1109-17.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01820, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-15K06792
[Journal Article] The crucial role of Erk2 in demyelinating inflammation in the central nervous system.2016
- Author(s)
  Okazaki R, Doi T, Hayakawa K, Morioka K, Imamura O, Takishima K, Hamanoue M, Sawada Y, Nagao M, Tanaka S, Ogata T
- Journal Title
  
  J Neuroinflammation
  
  Volume: 13 Issue: 1 Pages: 235-239
- DOI
  10.1186/s12974-016-0690-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282159, KAKENHI-PROJECT-15K06792
[Journal Article] Zbtb20 promotes astrocytogenesis during neocortical development2016
- Author(s)
  Nagao, M., Ogata, T., Sawada, Y., Gotoh, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 11102-11102
- DOI
  10.1038/ncomms11102
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06792, KAKENHI-PLANNED-22123003, KAKENHI-PROJECT-15H01820, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-26560410, KAKENHI-PROJECT-15H05773
[Journal Article] HMGN family proteins promote astrocyte differentiation of neural precursor cells.2014
- Author(s)
  Nagao.M., Lanjakornsiripan,D.,Itoh Y., Kishi Y., Ogata T., and Gotoh Y.
- Journal Title
  
  Stem Cells
  
  Volume: 32 Issue: 11 Pages: 2983-2997
- DOI
  10.1002/stem.1787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22123003, KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-25118706, KAKENHI-PROJECT-25840003
[Journal Article] Knockdown of Dock7 in vivo specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness.2012
- Author(s)
  鳥居知宏ら
- Journal Title
  
  American Journal of Molecular Biology
  
  Volume: ２ Issue: 03 Pages: 210-215
- DOI
  10.4236/ajmb.2012.23021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300123, KAKENHI-PROJECT-23650200, KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-23123502
[Journal Article] Paxillin is the target of c-Jun N-terminal kinase in Schwann cells and regulates migration2012
- Author(s)
  Miyamoto Y, Torii T, Yamamori N, Eguchi T, Nagao M, Nakamura K, Tanoue A, Yamauchi J.
- Journal Title
  
  Cell Signal
  
  Volume: 24 Issue: 11 Pages: 2061-2069
- DOI
  10.1016/j.cellsig.2012.06.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500437, KAKENHI-PUBLICLY-23123502
[Journal Article] Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation2011
- Author(s)
  Pei Z, Wang B, Chen G, Nagao M, Nakafuku M Campbell K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Issue: 4 Pages: 1675-1680
- DOI
  10.1073/pnas.1008824108
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23123502
[Presentation] クロマチンリモデリング因子Chd7による脳卒中後の反応性アストログリオーシス制御2024
- Author(s)
  長尾元史
- Organizer
  日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-23K24719
[Presentation] 脳卒中後の反応性アストログリオーシスにおけるクロマチンリモデリング因子Chd7の役割2023
- Author(s)
  長尾元史
- Organizer
  日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-23K24719
[Presentation] クロマチンリモデリング因子Chd7による脳卒中後の反応性アストログリオーシス制御2023
- Author(s)
  長尾元史
- Organizer
  日本神経科学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24719
[Presentation] 反応性アストロサイトにおけるクロマチンリモデリング因子Chd7の役割2022
- Author(s)
  長尾元史
- Organizer
  第６回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-18H03139
[Presentation] Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury.2017
- Author(s)
  Doi T, Ogata T, Sawada Y, Tanaka S, Nagao M.
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06792
[Presentation] Regulation of astrocyte production in the developing mouse neocortex.2017
- Author(s)
  Lanjakornsiripan D, Furutachi S, Pior B-J, Kishi Y, Hirabayashi Y, Nagao M, Gotoh Y.
- Organizer
  XIII European Meeting on Glial Cells in Health and Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06792
[Presentation] アストロサイト分化を制御する新しい転写因子2015
- Author(s)
  長尾元史
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K06792
[Presentation] HMGN family proteins promote astrocyte differentiation of neural precursor cells
- Author(s)
  Nagao M, Lanjakornsiripan D, Itoh Y, Kishi Y, Gotoh Y, Ogata T
- Organizer
  北米神経科学会（Neuroscience2014)
- Place of Presentation
  ワシントンDC (アメリカ合衆国)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24500437

1. OGATA TORU (00392192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 杉森道也 (20464026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鶴田文憲 (30571450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岸雄介 (00645236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 藤田幸 (60631215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 後藤由季子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 澤田泰宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagao Motoshi 長尾 元史

NAGAO Motoshi 長尾 元史

Research Projects

Research Products

Co-Researchers

アストロサイトリジュベネーションによる脳卒中後のリハビリテーション促進法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピゲノム操作を介したニューロン若返りによる脳卒中後のリハビリ促進法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a treatment for chronic stroke by converting reactive astrocytes into astrocytes in the critical period.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳卒中後のリハレスポンダー増加のための反応性アストログリオーシス制御に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms of motor function recovery after rehabilitation using glial transcriptome analysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The long term effect of rehabilitation effects on spastic symptoms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and characterization of a new regulator of astrocyte differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of the remyelination in chronic phase of spinal cord injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and characterization of novel factors that promote astrocyte differentiation of neural precursor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アストロサイトの分化制御と多様性を生み出す分子メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The crucial role of Erk2 in demyelinating inflammation in the central nervous system.2016

Author(s)

Journal Title

DOI

Data Source

Nagao Motoshi 長尾元史

NAGAO Motoshi 長尾元史