YAMAKAWA Ken 山川研

Researcher Number	00363664
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2014: 琉球大学, 医学(系)研究科(研究院), 講師 2010: 琉球大学, 医学研究科, 講師 2010: University of the Ryukyus, 大学院・医学研究科, 講師 2009: 琉球大学, 大学院・医学研究科, 助教 2008 – 2009: University of the Ryukyus, 医学研究科, 助教 … More 2007: University of the Ryukyus, 大学院・医学研究科, Assistant Professor 2006: 琉球大学, 大学院医学研究科, 助手 2005: 琉球大学, 大学院・医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Applied pharmacology Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 動脈硬化 / 血管内皮機能 / 血管内皮機能障害 / 玄米 / キサンチンオキシダーゼ / 脂質異常症 / 糖尿病 / 肥満 / メタボリックシンドローム / 代替エンドポイント / インスリン抵抗性 / 薬効評価 / 臨床薬理学 … More Except Principal Investigator … More Pharmacology / Central Nervous System / Diabetes Mellitus / Hypertension / 薬理学 / 脳・神経 / 糖尿病 / 循環器・高血圧 / インスリン感受性 / 血管内皮機能 / アディポネクチン / FMD / 代替エンドポイント / ヒト内皮機能 / レニンアンジオテンシン系 / サロゲートマーカー / 薬効評価システム / 心血管薬 Less

mechanisms of vascular endothelial function in metabolic syndrome subjects and novel therapeutic approachPrincipal Investigator
- Principal Investigator
  
  YAMAKAWA Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of the Ryukyus
Development of pharmacometric system for anti-atherogenic effect based on vascular endothelial functionPrincipal Investigator
- Principal Investigator
  
  YAMAKAWA Ken
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of the Ryukyus
Development of methods of clinical experiment and biomarkers for the assessment of cardiovascular drugs
- Principal Investigator
  
  UEDA Shinichiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of the Ryukyus
Mechanism and treatment of endothelial dysfunction in patients with metabolic syndrome and hypertension.
- Principal Investigator
  
  TAGAWA Tatsuya
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Seinan Jo Gakuin University
  University of the Ryukyus

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 肥満の脂肪組織における炎症.血管医学.122011
- Author(s)
  小塚智沙代, 比嘉盛丈, 屋比久浩市, 島袋充生, 山川研, 益崎裕章
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] 海外文献紹介・ビリルビンを増加させるHIV治療薬アタザナビルは2型糖尿病患者の血管内皮機能を改善する.Angiology Frontier. 102011
- Author(s)
  島袋充生, 山川研, 益崎裕章
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] これからの糖尿病薬物治療,求められる理念・予防の視点から.Mebio. 282011
- Author(s)
  益崎裕章, 比嘉盛丈, 山川研
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] テルミサルタン内服により降圧とともに内臓脂肪面積減少と糖代謝改善が得られた症例.セラピューティックリサーチ.322011
- Author(s)
  山川研, 島袋充生, 比嘉盛丈, 島袋毅, 田仲秀明, 益崎裕章
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-20590542
[Book] バイオマーカーとしての酸化ストレス・炎症の意義.Cardiovascular Frontier, 12010
- Author(s)
  山川研, 植田真一郎
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] 脂肪組織グルココルチコイド作用過剰とアディポサイエンス.アディポサイエンス,72010
- Author(s)
  益崎裕章, 山川研, 島袋充生
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-20590542
[Book] ACE阻害薬の薬理学的作用機序(ACE,ブラジキニンなど).Modern Physician, 302010
- Author(s)
  山川研, 植田真一郎
- Publisher
  新興医学出版社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] ARBの開発と薬剤特性.診断と治療,972009
- Author(s)
  山川研, 植田真一郎
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] 日本人の大規模臨床試験DIME study日本人本態性高血圧患者における降圧利尿薬の安全性、降圧効果、費用対効果に関するランダム化臨床試験高血圧(第4版)日本における最新の研究動向.日本臨床67巻増刊号7高血圧(下)2009
- Author(s)
  植田育子, 山川研, 植田真一郎
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-20590542
[Book] 新薬の広場高血圧治療薬【新薬展望2008】治療における最近の新薬の位置付け.医薬ジャーナル.44(増刊)2008
- Author(s)
  山川研, 植田真一郎
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice.2014
- Author(s)
  Matsumoto S, Shimabukuro M, Fukuda D, Soeki T, Yamakawa K, Masuzaki H, Sata M.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 13 Issue: 1 Pages: 30-30
- DOI
  10.1186/1475-2840-13-30
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-24591063, KAKENHI-PROJECT-25293184
[Journal Article] Effects of brown rice diet on visceral obesity and endothelial function: the BRAVO study.2014
- Author(s)
  1. Shimabukuro M, Higa M, Kinjo R, Yamakawa K, Tanaka H, Kozuka C, Yabiku K, Taira S, Sata M, Masuzaki H.
- Journal Title
  
  Br J Nutr
  
  Volume: 111 Issue: 2 Pages: 310-320
- DOI
  10.1017/s0007114513002432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-24591063, KAKENHI-PROJECT-24591338, KAKENHI-PROJECT-25293184
[Journal Article] Dihydropyridine calcium channel blockers inhibit free fatty acid-induced endothelial and rheological dysfunction.2013
- Author(s)
  Yasu T
- Journal Title
  
  Clinical Science [Epub ahead of print]
  
  Volume: - Issue: 5 Pages: 247-55
- DOI
  10.1042/cs20120311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590503, KAKENHI-PROJECT-24591063
[Journal Article] Lipid deposition in various sites of the skeletal muscles and liver exhibits a positive correlation with visceral fat accumulation in middle-aged Japanese men with metabolic syndrome.2013
- Author(s)
  Taira S, Shimabukuro M, Higa M, Yabiku K, Kozuka C, Ueda R, Sunagawa S, Ohshiro Y, Doi M, Nanba T, Kawamoto E, Nakayama Y, Nakamura H, Iha T, Nakachi S, Tomoyose T, Ikema T, Yamakawa K, Masuzaki H.
- Journal Title
  
  Intern Med.
  
  Volume: 52 Pages: 1561-71
- NAID
  130003365715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591063
[Journal Article] Miglitol,α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome2013
- Author(s)
  Shimabukuro M, et al
- Journal Title
  
  Int J Cardiol
  
  Volume: 167 Issue: 5 Pages: 2108-2113
- DOI
  10.1016/j.ijcard.2012.05.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-24591063, KAKENHI-PROJECT-24591338, KAKENHI-PROJECT-24659392, KAKENHI-PROJECT-25670390
[Journal Article] Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients.2012
- Author(s)
  Ken Yamakawa
- Journal Title
  
  Cardiology Research and Practice
  
  Volume: 2012 Pages: 754181-754181
- DOI
  10.1155/2012/754181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390159, KAKENHI-PROJECT-22590503, KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-24591063, KAKENHI-PROJECT-24591338, KAKENHI-PROJECT-24659392
[Journal Article] Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice2012
- Author(s)
  Kozuka C, Oyadomari S
- Journal Title
  
  Diabetes
  
  Volume: 61 Issue: 12 Pages: 3084-93
- DOI
  10.2337/db11-1767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390061, KAKENHI-PROJECT-23500413, KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-23650481, KAKENHI-PROJECT-23659114, KAKENHI-PROJECT-24591063, KAKENHI-PROJECT-24591338, KAKENHI-PUBLICLY-24116519
[Journal Article] Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients with Type 2 diabetes mellitus. Epub ahead of print2011
- Author(s)
  Shimabukuro M, Higa M, Tanaka H, Shimabukuro T, Yamakawa K, Masuzaki H.
- Journal Title
  
  Diabet Med.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction.2011
- Author(s)
  Shimabukuro M, Higa N, Asahi T, Yamakawa K, Oshiro Y, Higa M, Masuzaki H.
- Journal Title
  
  Diabetes Care. 34
  
  Pages: 686-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] バイオマーカーとしての酸化ストレス・炎症の意義2010
- Author(s)
  山川研, ほか
- Journal Title
  
  Cardiovascular Frontier
  
  Volume: 1 Pages: 237-41
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells.2010
- Author(s)
  Azekoshi Y, Yasu T, Watanabe S, Tagawa T, Abe S, Yamakawa K, Uehara Y, Momomura S, Urata H, Ueda S.
- Journal Title
  
  Hypertension. 56
  
  Pages: 136-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] ACE阻害薬の薬理学的作用機序(ACE、ブラジキニンなど)2010
- Author(s)
  山川研, 植田真一郎
- Journal Title
  
  Modern Physician 30
  
  Pages: 383-386
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] FFA causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells2010
- Author(s)
  Azekoshi Y, Yasu T, Watanabe S, Tagawa T, Uehara Y, Abe S, Urata H, Yamakawa K, Momomura S, Ueda S
- Journal Title
  
  Hypertension 56
  
  Pages: 136-142
- Data Source
  KAKENHI-PROJECT-19590541
[Journal Article] ARBの開発と薬剤特性2009
- Author(s)
  山川研, 植田真一郎
- Journal Title
  
  診断と治療 97
  
  Pages: 688-692
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Comparability and reproducibility of the carotid-femoral pulse wave velocity measurements using a multi-element carotid tonometry sensor.2008
- Author(s)
  Ueda I, Tagawa T, Watanabe S, Yamakawa K, Yasu T, Ueda S.
- Journal Title
  
  J Hum Hypertens. 22
  
  Pages: 699-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.2008
- Author(s)
  Minami H, Yasu T, Tagawa T, Yamakawa K, Ueda S.
- Journal Title
  
  Eur J Clin Pharmacol. 64
  
  Pages: 859-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590542
[Journal Article] Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.2008
- Author(s)
  Minami H, Yasu T, Tagawa T, Yamakawa K, Ueda S
- Journal Title
  
  Eur J Clin Pharmacol 64
  
  Pages: 859-62
- Data Source
  KAKENHI-PROJECT-19590541
[Journal Article] Comparability and reproducibility of the carotid-femoral pulse wave velocity measurements using a multi-element carotid tonometry sensor.2008
- Author(s)
  Ueda I, Tagawa T, Watanabe S, Yamakawa K, Yasu T, Ueda S
- Journal Title
  
  J Hum Hypertens 22
  
  Pages: 699-703
- Data Source
  KAKENHI-PROJECT-19590541
[Journal Article] Vascular lipotoxicity : endotbelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats.2007
- Author(s)
  Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N.
- Journal Title
  
  Endocrinology 148
  
  Pages: 160-165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study.2007
- Author(s)
  Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S
- Journal Title
  
  Am J Clin Nutr 86
  
  Pages: 923-8
- Data Source
  KAKENHI-PROJECT-19590541
[Journal Article] 脂肪毒性による血管内皮機能障害におけるレニン-アンギオテンシン系の役割に関する研究2007
- Author(s)
  田川辰也, 山川研, 植田真一郎
- Journal Title
  
  臨床薬理学の進歩 27
  
  Pages: 139-144
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Vascular lipotoxicity:endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats2007
- Author(s)
  Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N
- Journal Title
  
  Endocrinology 148
  
  Pages: 160-165
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Vascular lipotoxicity: endothelial dysfunction via fatty acid-induced reactive oxygen species pverproduction in obese Zucker diabetic rats2007
- Author(s)
  Chinen I, Shimabukuro M, Yamakawa K, Ueda S, et. al
- Journal Title
  
  Endocrinology 148
  
  Pages: 160-165
- Data Source
  KAKENHI-PROJECT-19590541
[Journal Article] 脂肪毒性による血管内皮機能障害におけるレニン-アンギオテンシン系の役割に関する研究2007
- Author(s)
  田川辰也, 山川研, 植田真一郎
- Journal Title
  
  臨床薬理学の進歩 27(印刷中)
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Vascular lipotoxicity:endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats2007
- Author(s)
  Chinen I, Shimabukuro M, Yamakawa K, iga N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N
- Journal Title
  
  Endocrinology 148
  
  Pages: 160-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans:a crossover controlled study2007
- Author(s)
  Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S
- Journal Title
  
  Am J Clin Nutr 86
  
  Pages: 923-928
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans : a crossover controlled study.2007
- Author(s)
  Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S.
- Journal Title
  
  Am J Clin Nutr 86
  
  Pages: 923-928
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] 脂肪毒性による血管内皮機能障害におけるレニン-アンギオテンシン系の役割に関する研究2007
- Author(s)
  田川辰也、山川研、植田真一郎
- Journal Title
  
  臨床薬理学の進歩 27
  
  Pages: 139-144
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Inhibition of renin-angiotensin system prevents free fatty acid-induced acute endothlial dysfunction in humans2005
- Author(s)
  Watanabe S, Tagawa T, Yamakawa K, Shimabukuro M, Ueda S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 2376-2380
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Inhibition of renin-angiotensin system prevents free fatty acid-induced acute endothlial dysfunction in humans.2005
- Author(s)
  Watanabe S, Tagawa T, Yamakawa K, Shimabukuro M, Ueda S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25・11
  
  Pages: 2376-2380
- Data Source
  KAKENHI-PROJECT-17590474
[Journal Article] Inhibition of renin-angiotensin system prevents free fatty acid-induced acute endothlial dysfunction in humans.2005
- Author(s)
  Watanabe S, Tagawa T, YamakawaK, Shimabukuro M, Ueda S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 2376-2380
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] 玄米由来成分γ-オリザノールによる膵島機能改善・抗肥満症効果の分子メカニズム2013
- Author(s)
  小塚智沙代, 屋比久浩市, 砂川澄人, 土井基嗣, 中山良朗, 平良伸一郎, 植田玲, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 玄米由来成分を活用した新規の糖尿病予防メカニズムの解明と臨床応用2013
- Author(s)
  小塚智沙代, 屋比久浩市, 砂川澄人, 平良伸一郎, 植田玲, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 高脂肪食負荷db/dbマウスにおけるキサンチンオキシダーゼ阻害薬の血管内皮機能改善効果2013
- Author(s)
  山川研, 岩渕敬子, 白倉尚, 田村みずほ, 比嘉盛丈, 島袋充生, 砂川澄人, 屋比久浩市, 小塚智沙代, 植田玲, 平良伸一郎, 池間朋己, 大城譲, 益崎裕章
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 玄米成分γ-オリザノールは視床下部小胞体ストレス抑制を介して高脂肪食嗜好性を軽減する2012
- Author(s)
  小塚智沙代, 屋比久浩市, 砂川澄人, 植田玲, 平良伸一郎, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  日本肥満学会
- Place of Presentation
  ホテルグランヴィア京都　京都府京都市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 動脈硬化を操る代謝シグナルネットワークの解明から治療へ高尿酸血症と血管機能異常・動脈硬化2012
- Author(s)
  益崎裕章, 山川研, 岩渕敬子, 屋比久浩市, 砂川澄人, 小塚智沙代, 植田玲, 平良伸一郎, 池間朋己, 比嘉盛丈, 島袋充生
- Organizer
  日本動脈硬化学会総会
- Place of Presentation
  ヒルトン福岡シーホーク　福岡県福岡市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 医食同源　「食」のセンシングとメタボエイジング日本屈指のメタボ県、沖縄から健康長寿復興を目指す食と新しい医療を考える2012
- Author(s)
  益崎裕章, 小塚智沙代, 屋比久浩市, 平良伸一郎, 砂川澄人, 植田玲, 大城譲, 池間朋己, 山川研, 比嘉盛丈, 島袋充生
- Organizer
  日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 玄米による新規抗肥満・抗糖尿病効果　視床下部小胞体ストレス抑制を介した高脂肪食嗜好性の軽減2012
- Author(s)
  小塚智沙代, 屋比久浩市, 砂川澄人, 平良伸一郎, 植田玲, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  日本内分泌学会
- Place of Presentation
  北九州国際会議場　福岡県北九州市
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 肥満糖尿病の病態:沖縄クライシスの現場からの考察2010
- Author(s)
  益崎裕章, 島袋充生, 山川研, 屋比久浩市, 池間朋己, 比嘉盛丈
- Organizer
  第48回日本糖尿病学会九州地方会シンポジウム1
- Place of Presentation
  別府市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] 進行性糖尿病性腎症患者を対象とした医師主導ランダム化臨床試験OKINAWA study実施における患者登録上の問題点2010
- Author(s)
  植田育子, 佐々木麻衣, 幸喜毅, 山川研, 城間勲, 屋良朝博, 長澤慶尚, 湧上民雄, 砂川優, 山里将浩, 平良伸一郎, 池間朋己, 神谷乗史, 小宮一郎, 益崎裕章, 植田真一郎
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山市
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] アンジオテンシンII受容体拮抗薬はFFA惹起性インスリン抵抗性を改善する2009
- Author(s)
  畔越陽子、小林真由美、安隆則、山川研、植田真一郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] 脂肪酸ならびにリポ多糖体(LPS)によるヒト白血球内レニンーアンギオテンシン系の活性化2009
- Author(s)
  大田聡子, 山内祐子, 山川研, 安隆則, 畦越陽子, 松下明子, 植田育子, 植田真一郎
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] Elevated FFA from visceral adipose tissue cause microcirculatory dysfunction partly via local renin-angiotensin system in mononuclear cells.2009
- Author(s)
  安隆則, 小林真由美, 岩崎大地, 山川研, 井上卓, 畦越陽子, 百村伸一, 浦田秀則, 植田真一郎
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] Elevated FFA from visceral adipose tissue cause microcirculatory dysfunction partly via local renin-angiotensin system in mononuclear cells.2009
- Author(s)
  安隆則, 畔越陽子, 山川研, 浦田秀則, 植田育子
- Organizer
  American College of Cardiology
- Place of Presentation
  Orland, USA
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] Ca拮抗薬によるFFA惹起性内皮機能低下と白血球活性化の改善2009
- Author(s)
  安隆則、小林真由美、山川研、植田真一郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-10-11
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] Elevated FFA from visceral adipose tissue cause microcirculatory dysfunction partly via local renin-angiotensin system in mononuclear cells.2009
- Author(s)
  Yasu T, Azekoshi Y, Yamakawa K, Urata H, Ueda S
- Organizer
  American Collage of Cardiology
- Place of Presentation
  Orland, USA
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] 脂肪酸ならびにリポ多糖体(LPS)によるヒト白血球内レニンーアンギオテンシン系の活性化2009
- Author(s)
  大田聡子, 山川研
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] メタボリックシンドロームにおけるインスリン感受性と血管内皮機能の関連2008
- Author(s)
  山川研、島袋充生、田川辰也、植田真一郎
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] Angiotensin II production in human mononuclear cells is enhanced by elevated FFA.2008
- Author(s)
  Ueda S, Azekoshi Y, Yasu T, Yamakawa K, Urata H
- Organizer
  Possible implication in endothelial dysfunction as mobile renin-angiotensin system. Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] アンジオテンシII受容体阻害はヒトにおいて遊離脂肪酸惹起性インスリン抵抗性を改善させる2008
- Author(s)
  畔越陽子, 小林真由美, 山川研, 安隆則, 植田真一郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] Enhanced Angiotensin II Forming Activity In Mononuclear Cell By Elevated Free Fatty Acid : Possible Implication in Endothelial Dysfunction as Mobile Renin-Angiotensin System.2008
- Author(s)
  Ueda S, Azekoshi Y, Yasu T, Yamakawa K, Abe T, Uehara Y, Urata H
- Organizer
  Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-01-10
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] Ca拮抗薬によるFFA惹起性内皮機能低下と白血球活性化の改善2008
- Author(s)
  安隆則, 小林真由美, 山川研, 植田真一郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] メタボリック症候群を想定したヒト脂肪負荷血液流動性低下モデルにおける長時間持続型ニフェジピン介入研究2008
- Author(s)
  安隆則, 小林真由美, 山川研, 畔越陽子, 百村伸一, 植田真一郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20590542
[Presentation] メタボリックシンドロームにおける血管内皮機能におよぼす因子の検討2007
- Author(s)
  山川研, 島袋充生, 比嘉南夫, 安隆則, 田川辰也, 植田真一郎
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄コンベンションセンター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Research about factors which influence endothelial function in patients with Metabolic Syndrome.2007
- Author(s)
  Yamakawa K, Shimabukuro M, Higa N, Yasu T, Tagawa T, Ueda S.
- Organizer
  The 30th Scientific Annual Meeting of the Japanese Society of Hypertension
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] メタボリック症候群における血管内皮機能とインスリン感受性の関連2007
- Author(s)
  山川研, 他
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄県
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-19590541
[Presentation] Impairment of vascular nitric oxidebioavailability in subjects with impaired glucose tolerance : a potential link to insulin resistance and blood pressure.2006
- Author(s)
  Shimabukuro M, Higa N, Yamakawa K, Tagawa T, Ueda S.
- Organizer
  The 21th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Inhibition of renin-angiotensin system prevents acute endothelial dysfunction induced by free fatty acids2006
- Author(s)
  Watanabe S, Yamakawa K, Tagawa T, Shimabukuro M, Ueda S.
- Organizer
  第21回国際高血圧学会学術会議
- Place of Presentation
  福岡国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Inhibition of renin-angiotensin system prevents acute endothelial dysfunction induced by free fatty acids.2006
- Author(s)
  Watanabe S, Yamakawa K, Tagawa T, Shimabukuro M, Ueda S.
- Organizer
  The 21th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Impact of visceral fat obesity in endothelial function in patients with Metabolic Syndrome2006
- Author(s)
  Yamakawa K, Shimabukuro M, Higa N, Tagawa T, Ueda S.
- Organizer
  第21回国際高血圧学会学術会議
- Place of Presentation
  福岡国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Impact of visceral fat obesity in endothelial function in patients with Metabolic Syndrome.2006
- Author(s)
  Yamakawa K, Shimabukuro M, Higa N, Tagawa T, Ueda S.
- Organizer
  The 21th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] Impairment of vascular nitric oxidebioavailability in subjects with impaired glucose tolerance:a potential link to insulin resistance and blood pressure2006
- Author(s)
  Shimabukuro M, Higa N, Yamakawa K, Tagawa T, Ueda S.
- Organizer
  第21回国際高血圧学会学術会議
- Place of Presentation
  福岡国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590474
[Presentation] 玄米による食行動の改善を介した血管機能異常改善効果
- Author(s)
  小塚智沙代, 砂川澄人, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] メタボリックストレスモデルにおけるキサンチンオキシダーゼ阻害薬の血管内皮機能改善効果について
- Author(s)
  砂川澄人, 山川研, 岩渕敬子, 小塚智沙代, 白倉尚, 田村みずほ, 仲村英昭, 土井基嗣, 中山良朗, 植田玲, 新垣多賀子, 平良伸一郎, 池間朋己, 友寄毅昭, 島尻佳典, 大城譲, 比嘉盛丈, 島袋充生, 益崎裕章
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡国際会議場・福岡サンパレス
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24591063
[Presentation] 玄米有効成分による膵β細胞保護効果の新規メカニズム
- Author(s)
  小塚智沙代, 砂川澄人, 中山良朗, 土井基嗣, 平良伸一郎, 植田玲, 比嘉盛丈, 池間朋己, 山川研, 高山千利, 松下正之, 親泊政一, 島袋充生, 益崎裕章
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡国際会議場・福岡サンパレス
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24591063

1. UEDA Shinichiro (80285105)

# of Collaborated Projects: 3 results

# of Collaborated Products: 47 results
2. OHYA Yusuke (30240964)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YASU Takanori (40265278)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
4. URATA Hidenori (30289524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. MATSUOKA Hidehiro (80248393)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIMABUKURO Michio (60271144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
7. HIGA Moritake (70347152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. MASUZAKI Hiroaki (00291899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
9. TAGAWA Tatsuya (50347142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. 屋比久浩市 (70545748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. OYADOMARI Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 親泊美帆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAKAWA Ken 山川 研

Research Projects

Research Products

Co-Researchers

mechanisms of vascular endothelial function in metabolic syndrome subjects and novel therapeutic approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of pharmacometric system for anti-atherogenic effect based on vascular endothelial functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of methods of clinical experiment and biomarkers for the assessment of cardiovascular drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism and treatment of endothelial dysfunction in patients with metabolic syndrome and hypertension.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肥満の脂肪組織における炎症.血管医学.122011

Author(s)

Publisher

Data Source

[Book] 海外文献紹介・ビリルビンを増加させるHIV治療薬アタザナビルは2型糖尿病患者の血管内皮機能を改善する.Angiology Frontier. 102011

Author(s)

Publisher

Data Source

[Book] これからの糖尿病薬物治療,求められる理念・予防の視点から.Mebio. 282011

Author(s)

Publisher

Data Source

[Book] テルミサルタン内服により降圧とともに内臓脂肪面積減少と糖代謝改善が得られた症例.セラピューティックリサーチ.322011

Author(s)

Publisher

Data Source

[Book] バイオマーカーとしての酸化ストレス・炎症の意義.Cardiovascular Frontier, 12010

Author(s)

Publisher

Data Source

[Book] 脂肪組織グルココルチコイド作用過剰とアディポサイエンス.アディポサイエンス,72010

Author(s)

Publisher

Data Source

[Book] ACE阻害薬の薬理学的作用機序(ACE,ブラジキニンなど).Modern Physician, 302010

Author(s)

Publisher

Data Source

[Book] ARBの開発と薬剤特性.診断と治療,972009

Author(s)

Publisher

Data Source

[Book] 日本人の大規模臨床試験DIME study日本人本態性高血圧患者における降圧利尿薬の安全性、降圧効果、費用対効果に関するランダム化臨床試験 高血圧(第4版)日本における最新の研究動向.日本臨床67巻増刊号7高血圧(下)2009

Author(s)

Publisher

Data Source

[Book] 新薬の広場 高血圧治療薬【新薬展望2008】治療における最近の新薬の位置付け.医薬ジャーナル.44(増刊)2008

Author(s)

Publisher

Data Source

[Journal Article] Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of brown rice diet on visceral obesity and endothelial function: the BRAVO study.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dihydropyridine calcium channel blockers inhibit free fatty acid-induced endothelial and rheological dysfunction.2013

Author(s)

YAMAKAWA Ken 山川研

[Book] 日本人の大規模臨床試験DIME study日本人本態性高血圧患者における降圧利尿薬の安全性、降圧効果、費用対効果に関するランダム化臨床試験高血圧(第4版)日本における最新の研究動向.日本臨床67巻増刊号7高血圧(下)2009

[Book] 新薬の広場高血圧治療薬【新薬展望2008】治療における最近の新薬の位置付け.医薬ジャーナル.44(増刊)2008