Hirose Tomoyasu 廣瀬友靖

… Alternative Names

HIROSE Tomoyasu 廣瀬友靖

廣瀬友靖ヒロセトモヤス

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Researcher Number	00370156
Other IDs
Affiliation (Current)	2025: 北里大学, 感染制御科学府, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 北里大学, 感染制御科学府, 教授 2014 – 2021: 北里大学, 感染制御科学府, 准教授 2016: 北里大学, 北里生命化学研究所感染制御科学府, 准教授 2012 – 2013: 北里大学, その他の研究科, 准教授 2010 – 2011: 北里大学, 大学院・感染制御科学府, 准教授 2007: Kitasato Institute, 社団法人北里研究所・基礎研究所, 研究員 2006: (社)北里研究所, 基礎研究所, 研究員
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 54030:Infectious disease medicine-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Natural medicines
Keywords	Principal Investigator 全合成 / 天然物 / 新作用 / 収束的 / ライブラリー指向 / イベルメクチン / ライブラリー構築 / 誘導体 / Ivermectin / Avermectin … More / ルミナミシン / リレー全合成 / 抗嫌気性菌活性 / 抗生物質 / 抗菌活性 / 抗嫌気性菌 / Clostridioides difficile / リレー合成 / 14員環ラクトン / 10員環ラクトン / 構造活性相関 / シスデカリン / ラクトン / 微生物発酵 / Luminamicin / actinoallolide / 新規天然物 / トリパノソーマ / マクロライド / アクチノアロライド / デッツ反応 / Naphtacemycin / MRSA / 不斉全合成 / 擬アミナール / ワンポットカスケード反応 / インドールアルカロイド / ヒドロキシアパリシン / アパリシン類 / 抗マラリア活性 / 有機化学 / guadinomine / TypeIII分泌機構 / Click Chemistry / 抗感染症薬 / guadionmine / Type III分泌機構 … More Except Principal Investigator C. difficile / 放線菌 / 生合成 / Clostridioides difficile / ルミナミシン / 天然化合物 / 芽胞 / ゼブラフィッシュ / mTOR / 阻害剤 / Wnt / 抗嫌気性細菌 / 誘導体合成 / 微生物代謝産物 / TypeII脂肪酸合成酵素 / マラリア感染予防 / マラリア原虫 / pfFabI Less

抗嫌気性菌活性を示す微生物由来２環性デプシペプチドを標的とした全合成と創薬研究Principal Investigator
- Principal Investigator
  
  廣瀬友靖
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
生体高分子認識構造α-solenoidを標的とした中分子創薬の基盤構築
- Principal Investigator
  
  西谷直之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Clostridioides difficileに対する芽胞形成阻害物質の探索と作用機構解析
- Principal Investigator
  
  松井秀仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kitasato University
ルミナミシンの生合成経路解明とC. difficile感染症治療薬への応用
- Principal Investigator
  
  稲橋佑起
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University
ライブラリー指向型イベルメクチン全合成法の確立と誘導体創製研究Principal Investigator
- Principal Investigator
  
  廣瀬友靖
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Producing the luminamicin analogs by genetic engineering
- Principal Investigator
  
  Inahashi Yuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University
Total synthesis of 10-14 membered ring fused dimacrolides, potent narrow antimicrobial activitiesPrincipal Investigator
- Principal Investigator
  
  Hirose Tomoyasu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Toward the total synthesis of novel anti-protozoal 12-membered macrolidesPrincipal Investigator
- Principal Investigator
  
  Hirose Tomoyasu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Screening of Plasmodium falciparum enoyl-Acyl carrier protein reductase (PfFabI) inhibitors from microbial metabolites for prophylaxis and blocking transmission of malaria
- Principal Investigator
  
  Aki Ishiyama
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Kitasato University
Total Synthesis of Naphthacemycins, Possession of Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)Principal Investigator
- Principal Investigator
  
  HIROSE Tomoyasu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Enantioselective total synthesis of(+)-Hydroxyapparicine, potent antimalarial indole alkaloid.Principal Investigator
- Principal Investigator
  
  HIROSE Tomoyasu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
タイプIII分泌機構阻害活性に着目した抗感染症薬の創製Principal Investigator
- Principal Investigator
  
  廣瀬友靖
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato Institute

[Book] 月刊ファインケミカル2月号2014
- Author(s)
  廣瀬友靖、砂塚敏明
- Total Pages
  8
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24590019
[Book] クリックケミストリー　–基礎から実用まで-2014
- Author(s)
  廣瀬友靖、砂塚敏明
- Total Pages
  10
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-80582024
- Author(s)
  Kimura So-ichiro、Watanabe Yoshihiro、Mikasa Yudai、Miyano Rei、Tokiwa Toshiyuki、Nonaka Kenichi、Nakashima Takuji、Noguchi Yoshihiko、Hirose Tomoyasu、Sunazuka Toshiaki、Hokari Rei、Ishiyama Aki、Iwatsuki Masato
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 4 Pages: 206-213
- DOI
  10.1038/s41429-023-00699-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] A novel macrolide?Del-1 axis to regenerate bone in old age2024
- Author(s)
  Sirisereephap Kridtapat、Tamura Hikaru、Lim Jong-Hyung、Surboyo Meircurius Dwi Condro、Isono Toshihito、Hiyoshi Takumi、Rosenkranz Andrea L.、Sato-Yamada Yurie、Domon Hisanori et al.
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108798-108798
- DOI
  10.1016/j.isci.2024.108798
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24517, KAKENHI-PROJECT-23K24525
[Journal Article] A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-00012024
- Author(s)
 Janthanom Rattiya、Kikuchi Yuta、Kanto Hiroki、Hirose Tomoyasu、Tahara Arisu、Ishii Takahiro、Thamchaipenet Arinthip、Inahashi Yuki
- Journal Title
 
 Beilstein Journal of Organic Chemistry
 
 Volume: 20 Pages: 497-503
- DOI
 10.3762/bjoc.20.44
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K06535, KAKENHI-PLANNED-19H05685
[Journal Article] Development of a nitrogen-bound hydrophobic auxiliary: application to solid/hydrophobic-tag relay synthesis of calpinactam2023
- Author(s)
  Nakahara Hiroki、Sennari Goh、Noguchi Yoshihiko、Hirose Tomoyasu、Sunazuka Toshiaki
- Journal Title
  
  Chemical Science
  
  Volume: 14 Issue: 25 Pages: 6882-6889
- DOI
  10.1039/d3sc01432k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] Hakuhybotrol, a polyketide produced by Hypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED2023
- Author(s)
 Watanabe Yoshihiro、Takahashi Shuhei、Ito Sho、Tokiwa Toshiyuki、Noguchi Yoshihiko、Azami Haruki、Kojima Hiroki、Higo Mayuka、Ban Sayaka、Nagai Kenichiro、Hirose Tomoyasu、Sunazuka Toshiaki、Yaguchi Takashi、Nonaka Kenichi、Iwatsuki Masato
- Journal Title
 
 Organic & Biomolecular Chemistry
 
 Volume: 21 Issue: 11 Pages: 2320-2330
- DOI
 10.1039/d2ob02286a
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K05293, KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] Studies on the Catechin Constituents of Bark of Cinnamomum sieboldii2023
- Author(s)
 Hirose Tomoyasu、Ozaki Kaori、Saito Yukiko、Takai-Todaka Reiko、Matsui Hidehito、Honsho Masako、Iwatsuki Masato、Asami Yukihiro、Katayama Kazuhiko、Sunazuka Toshiaki、Hanaki Hideaki、Teruya Toshiaki
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 71 Issue: 5 Pages: 374-379
- DOI
 10.1248/cpb.c22-00922
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2023-05-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K06535
[Journal Article] Increase in TPSB2 and TPSD1 Expression in Synovium of Hip Osteoarthritis Patients Who Are Overweight2023
- Author(s)
  Tsuchiya M, Fukushima K, Takata K, Ohashi Y, Uchiyama K, Takahira N, Saito H, Tsukada A, Inoue G, Takaso M, Uchida K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24 Issue: 18 Pages: 11532-11532
- DOI
  10.3390/ijms241813871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16719, KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K08617
[Journal Article] New antimalarial fusarochromanone analogs produced by the fungal strain Fusarium sp. FKI-95212023
- Author(s)
  Watanabe Yoshihiro、Arakawa Emi、Kondo Naozumi、Nonaka Kenichi、Ikeda Akari、Hirose Tomoyasu、Sunazuka Toshiaki、Hokari Rei、Ishiyama Aki、Iwatsuki Masato
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 7 Pages: 384-391
- DOI
  10.1038/s41429-023-00617-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07106, KAKENHI-PROJECT-22K06535
[Journal Article] A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction2023
- Author(s)
  Aizawa Kenichi、Ikeda Akari、Tomida Shota、Hino Koki、Sugita Yuuki、Hirose Tomoyasu、Sunazuka Toshiaki、Kido Hiroshi、Yokoyama Shigeyuki、Nagai Ryozo
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 1 Pages: 87-87
- DOI
  10.3390/cells13010087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06535
[Journal Article] Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-04992023
- Author(s)
  4.Haruki Azami, Yoshihiro Watanabe, Kazunari Sakai, Hiroki Nakahara, Toshiyuki Tokiwa, Kenichi Nonaka, Yoshihiko Noguchi, Yuriko Nagano, Tomoyasu Hirose, Toshiaki Sunazuka, Hidehito Matsui, Naoaki Arima, Kazutoyo Abe, Hideaki Hanaki, Hiroki Kojima, Masato Iwatsuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Pages: 156-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535
[Journal Article] A novel aromatic compound from the fungus Synnemellisia sp. FKR-09212023
- Author(s)
  Tahara Arisu、Tani Kazuki、Wakatsuki Miyu、Tokiwa Toshiyuki、Higo Mayuka、Nonaka Kenichi、Hirose Tomoyasu、Hokari Rei、Ishiyama Aki、Iwatsuki Masato、Watanabe Yoshihiro、Honsho Masako、Asami Yukihiro、Matsui Hidehito、Sunazuka Toshiaki、Hanaki Hideaki、Teruya Toshiaki、Ishii Takahiro
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 12 Pages: 706-710
- DOI
  10.1038/s41429-023-00657-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05806, KAKENHI-PROJECT-22K06535
[Journal Article] Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-05642022
- Author(s)
  Yoshihiro Watanabe, Kodai Hachiya, Akari Ikeda, Kenichi Nonaka, Mayuka Higo, Reiko Muramatsu, Chikako Noguchi, Masako Honsho, Yukihiro Asami, Yuki Inahashi, Tomoyasu Hirose, Hidehito Matsui, Toshiaki Sunazuka, Hideaki Hanaki, Takahiro Ishii, Toshiaki Teruya, Rei Hokari, Aki Ishiyama, Masato Iwatsuki
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 85 Issue: 11 Pages: 2641-3649
- DOI
  10.1021/acs.jnatprod.2c00719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-20K07106
[Journal Article] Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-90082022
- Author(s)
 Watanabe Yoshihiro、Yoshida Yurika、Tokiwa Toshiyuki、Higo Mayuka、Ban Sayaka、Ikeda Akari、Noguchi Yoshihiko、Hirose Tomoyasu、Sunazuka Toshiaki、Nonaka Kenichi、Yaguchi Takashi、Iwatsuki Masato
- Journal Title
 
 J. Gen. Appl. Microbiol.
 
 Volume: 68 Issue: 4 Pages: 200-206
- DOI
 10.2323/jgam.2022.03.002
- ISSN
 0022-1260, 1349-8037
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K05293, KAKENHI-PROJECT-22K06535
[Journal Article] Pot-economical synthesis of cyclic depsipeptides using a hydrophobic anchor molecule toward the construction of an unnatural peptide library2022
- Author(s)
  Yoshihiko Noguchi, Shogo Sekikawa, Yutaka Nogaki, Satake Yudai, Norifumi Murashima, Takashi Kirisawa, Guido Schiffer, Johannes Koebberling, Tomoyasu Hirose, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 128 Pages: 133100-133100
- DOI
  10.1016/j.tet.2022.133100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535
[Journal Article] Afidopyropen, a novel insecticide originating from microbial secondary extracts2022
- Author(s)
  Ryo Horikoshi, Kimihiko Goto, Masaaki Mitomi, Kazuhiko Oyama, Tomoyasu Hirose, Toshiaki Sunazuka and Satoshi Omura
- Journal Title
  
  Sci. Rep.
  
  Volume: 12 Issue: 1 Pages: 2827-2827
- DOI
  10.1038/s41598-022-06729-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06535
[Journal Article] Jietacin derivative, (Z)-2-(8-oxodec-9-yn-1-yl)-1-vinyldiazene 1-oxide, inhibits TNF-α-mediated inflammatory cytokine and chemokine expression via suppression of p65 phosphorylation and importin β1 expression in synovial cell line SW9822022
- Author(s)
  Kyoko Muneshige, Yuki Inahashi, Makoto Itakura, Masato Iwatsuki, Tomoyasu Hirose, Gen Inoue, Masashi Takaso, Toshiaki Sunazuka, Yoshihisa Ohashi, Etsuro Ohta, Kentaro Uchida
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 1 Pages: 5-5
- DOI
  10.3390/ph16010005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-20K06914, KAKENHI-PUBLICLY-21H00436
[Journal Article] Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases2022
- Author(s)
  Yonezawa Honami、Ikeda Akari、Takahashi Ryo、Endo Haruka、Sugawara Yasuyo、Goto Mikako、Kanno Mirute、Ogawa Sosuke、Nakamura Karin、Ujiie Haruki、Iwatsuki Masato、Hirose Tomoyasu、Sunazuka Toshiaki、Uehara Yoshimasa、Nishiya Naoyuki
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103912-103912
- DOI
  10.1016/j.isci.2022.103912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07182, KAKENHI-PROJECT-22K06535
[Journal Article] Fungal secondary metabolite exophillic acid selectively inhibits the entry of hepatitis B and D viruses2022
- Author(s)
  Chisa Kobayashi, Yoshihiro Watanabe, Mizuki Oshima, Tomoyasu Hirose, Masako Yamasaki, Masashi Iwamoto, Masato Iwatsuki, Yukihiro Asami, Kouji Kuramochi, Kousho Wakae, Hideki Aizaki, Masamichi Muramatsu, Camille Sureau, Toshiaki Sunazuka and Koichi Watashi
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 4 Pages: 764-764
- DOI
  10.3390/v14040764
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-21K15453
[Journal Article] A Chemical Degradation-Inspired Total Synthesis of the Antibiotic Macrodiolide, Luminamicin2022
- Author(s)
  Aoi Kimishima, Hiroyasu Ando, Goh Sennari, Yoshihiko Noguchi, Shogo Sekikawa, Toru Kojima, Motoyoshi Ohara, Yoshihiro Watanabe, Yuki Inahashi, Hirokazu Takada, Akihiro Sugawara, Takanori Matsumaru, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 144 Issue: 50 Pages: 23148-23157
- DOI
  10.1021/jacs.2c10856
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-20K07105
[Journal Article] Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA22022
- Author(s)
  Anna Nakanishi, Hiroki Okumura, Tadahiro Hashita, Aya Yamashita, Yuka Nishimura, Chihiro Watanabe, Sakina Kamimura, Sanae Hayashi, Shuko Murakami, Kyoko Ito, Takahiro Iwao, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Yasuhito Tanaka, Tamihide Matsunaga
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 11 Pages: 2468-2468
- DOI
  10.3390/v14112468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-21H04865
[Journal Article] Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C2021
- Author(s)
  Shu Takahashi, Aoi Kimishima, Tomoyasu Hirose, Takeshi Yamada, Akihiro Sugawara, Tatsuya Shirahata, Yoshihiko Noguchi, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Yoshinori Kobayashi, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 67 Pages: 152895-152895
- DOI
  10.1016/j.tetlet.2021.152895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-20K05502, KAKENHI-PROJECT-21K05059
[Journal Article] Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone2021
- Author(s)
  Motoyoshi Ohara, Akari Ikeda, Asuka Nakajuma, Takanori Ono, Yoshihiko Noguchi,Akito Watanabe, Tomoyasu Hirose, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 66 Pages: 152799-152799
- DOI
  10.1016/j.tetlet.2020.152799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-21K05059
[Journal Article] Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables a Synthesis of 14-Membered Macrolactone of Luminamicin2021
- Author(s)
  Akihiro Sugawara, Hirokazu Takada, Tomoyasu Hirose, Aoi Kimishima, Takeshi Yamada, Masaki Toda, Toru Kojima, Takanori Matsumaru, Toshiaki Sunazuka
- Journal Title
  
  Organic Letters
  
  Volume: 23 Issue: 5 Pages: 1758-1763
- DOI
  10.1021/acs.orglett.1c00183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-20K05502, KAKENHI-PROJECT-21K05059
[Journal Article] Absolute structure and anti-oxidative activity of chaetochiversin C isolated from fungal strain Neocosmospora sp. FKI-7792 by physicochemical screening2020
- Author(s)
  Hirotaka Matsuo, Tomoyasu Hirose, Takayuki Mokudai, Kenichi Nonaka, Yoshimi Niwano, Toshiaki Sunazuka, Yoko Takahashi, Satoshi Omura and Takuji Nakashima
- Journal Title
  
  Journal of General and Applied Microbiology
  
  Volume: 66 Issue: 3 Pages: 181-187
- DOI
  10.2323/jgam.2019.06.001
- NAID
  130007891102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586
[Journal Article] RAPID EXPLORATION OF NOVEL ANTHELMINTIC AGENTS FROM ALKYNE-BEARING AVERMECTIN DERIVATIVES VIA CLICK CHEMISTRY2020
- Author(s)
  Tomoyasu Hirose, Akari Ikeda, Ayumi Tsutsui, Satoshi Omura, and Toshiaki Sunazuka
- Journal Title
  
  Heterocycles
  
  Volume: 101 Issue: 1 Pages: 116-125
- DOI
  10.3987/com-19-s(f)18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586
[Journal Article] Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approache2020
- Author(s)
  Watanabe, A., Noguchi, Y., Hirose, T., Monma, S., Satake T., Arai, M., Masuda, K., Murashima, N., Shiomi, R., Omura, S., and Sunazuka, T.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 61 Issue: 13 Pages: 151699-151703
- DOI
  10.1016/j.tetlet.2020.151699
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318
[Journal Article] Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity2019
- Author(s)
  Hayashi Yumi、Fukasawa Wataru、Hirose Tomoyasu、Iwatsuki Masato、Hokari Rei、Ishiyama Aki、Kanaida Masahiro、Nonaka Kenichi、Take Akira、Otoguro Kazuhiko、Omura Satoshi、Shiomi Kazuro、Sunazuka Toshiaki
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 7 Pages: 2180-2184
- DOI
  10.1021/acs.orglett.9b00483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08343, KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-18K06586
[Journal Article] Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae2019
- Author(s)
  Sakai, K., Unten, Y., Iwatsuki, M., Matsuo, H., Fukasawa, W., Hirose, T., Chinen, T., Nonaka, K., Nakashima, T., Sunazuka, T., Usui, T., Murai, M., Miyoshi, H., Asami, Y., Omura, S., and Shiomi, K.
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 72 Issue: 9 Pages: 645-652
- DOI
  10.1038/s41429-019-0197-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05458, KAKENHI-PROJECT-18K06586
[Journal Article] Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with the virus internalization process2019
- Author(s)
  Tran Huu Dat, Ryuichi Sugamata, Tomoyasu Hirose, Shoichi Suzuki, Yoshihiko Noguchi, Akihiro Sugawara, Fuyu Ito, Tomoko Yamamoto, Shoji Kawachi, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka, Naoki Ito, Masakazu Mimaki, Kazuo Suzuki
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 10 Pages: 759-768
- DOI
  10.1038/s41429-019-0204-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-18K07887, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K18120
[Journal Article] Jietacins, azoxy natural products, as novel NF-kB inhibitors: discovery, synthesis, biological activity, and mode of action2019
- Author(s)
  Mariko Watanabe, Akihiro Sugawara, Yoshihiko Noguchi, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Ryouichi Horie
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 178 Pages: 636-647
- DOI
  10.1016/j.ejmech.2019.05.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K08728
[Journal Article] Synthesis and insecticidal efficacy of pyripyropene derivatives. Part II-Invention of afidopyropen2019
- Author(s)
  Kimihiko Goto, Ryo Horikoshi, Masaaki Mitomi, Kazuhiko Oyama, Tomoyasu Hirose, Toshiaki Sunazuka and Satoshi Omura
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 9 Pages: 661-681
- DOI
  10.1038/s41429-019-0193-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629
[Journal Article] Synthesis of pyripyropene derivatives and their pest-control efficacy2019
- Author(s)
  Kimihiko Goto, Ryo Horikoshi, Satoshi Nakamura, Masaaki Mitomi, Kazuhiko Oyama, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura
- Journal Title
  
  Journal of Pesticide Science
  
  Volume: 44 Issue: 4 Pages: 255-263
- DOI
  10.1584/jpestics.D19-032
- NAID
  130007748678
- ISSN
  1348-589X, 1349-0923
- Year and Date
  2019-11-20
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629
[Journal Article] Synthesis of the Antimalarial Peptide Aldehyde, a Precursor of Kozupeptin A, Utilizing a Designed Hydrophobic Anchor Molecule2019
- Author(s)
  Yumi Hayashi, Tomoyasu Hirose, Masato Iwatsuki, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Org. Lett.
  
  Volume: 21 Issue: 20 Pages: 8229-8233
- DOI
  10.1021/acs.orglett.9b02966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629
[Journal Article] Synthesis and evaluation of antibacterial activity of bottromycins2018
- Author(s)
  Takeshi Yamada, Miu Yagita, Yutaka Kobayashi, Goh Sennari, Hiroyuki Shimamura, Hidehito Matsui, Yuki Horimatsu, Hideaki Hanaki, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 83 Issue: 13 Pages: 7135-7149
- DOI
  10.1021/acs.joc.8b00045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08219, KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-16K08174
[Journal Article] Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes2018
- Author(s)
  Sugawara Akihiro、Kubo Masahiko、Hirose Tomoyasu、Yahagi Kyoichi、Tsunoda Noriaki、Noguchi Yoshihiko、Nakashima Takuji、Takahashi Yoko、Welz Claudia、Mueller Dennis、Mertens Christina、Koebberling Johannes、?mura Satoshi、Sunazuka Toshiaki
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 145 Pages: 524-538
- DOI
  10.1016/j.ejmech.2017.12.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-18K06586
[Journal Article] Pestynol, a novel antifungal compound discovered using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-based assay2018
- Author(s)
  Katsuyuki Sakai, Tomoyasu Hirose, Masato Iwatsuki, Takumi Chinen, Toru Kimura, Takuya Suga, Kenichi Nonaka, Takuji Nakashima, Toshiaki Sunazuka, Takeo Usui, Yukihiro Asami, Satoshi Omura, Kazuro Shiomi
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 81 Issue: 7 Pages: 1604-1609
- DOI
  10.1021/acs.jnatprod.8b00200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-16K08174
[Journal Article] Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups2018
- Author(s)
  Kimihiko Goto, Ryo Horikoshi, Masaaki Mitomi, Kazuhiko Oyama, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 9 Pages: 785-797
- DOI
  10.1038/s41429-018-0064-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-16K08174
[Journal Article] Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.2017
- Author(s)
  Atsushi Fukumoto, Yong-Pil Kim, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Hideaki Hanaki, Satoshi Omura and Kazuro Shiomi.
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Issue: 5 Pages: 568-573
- DOI
  10.1038/ja.2017.29
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-15K07866
[Journal Article] Total Synthesis and Determination of the Absolute Configuration of Naturally Occurring Mangromicin A, with Potent Antitrypanosomal Activity2017
- Author(s)
  Hirokazu Takada, Takeshi Yamada, Tomoyasu Hirose, Takuma Ishihara, Takuji Nakashima, Yoko Takahashi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 1 Pages: 230-233
- DOI
  10.1021/acs.orglett.6b03512
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18836, KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-16K08174
[Journal Article] Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and biological evaluation2017
- Author(s)
  Goh Sennari, Ryo Saito, Tomoyasu Hirose, Masato Iwatsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi Omura, and Toshiaki Sunazuka
- Journal Title
  
  Scientific Report
  
  Volume: - Issue: 1
- DOI
  10.1038/s41598-017-07718-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07866
[Journal Article] Stereo- and substituent-enabled divergent synthesis of 5,6-spiroketal analogs of avermectin containing a triazole function.2017
- Author(s)
  Takeshi Yamada, Yuki Horimatsu, Tomoyasu Hirose, Akihiro Sugawara, Satoshi Omura and Toshiaki Sunazuka.
- Journal Title
  
  Tetrahedron Lett. 58
  
  Volume: 58 Issue: 32 Pages: 3119-3124
- DOI
  10.1016/j.tetlet.2017.06.072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-17K08219, KAKENHI-PROJECT-15K07866
[Journal Article] Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance.2017
- Author(s)
  Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Issue: 5 Pages: 574-581
- DOI
  10.1038/ja.2016.141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-15K07866
[Journal Article] 5-O-Mycaminosyltylonolide antibacterial derivatives: Design, synthesis and bioactivity2017
- Author(s)
  Akihiro Sugawara, Hitomi Maruyama, Sho Shibusawa, Hidehito Matsui, Tomoyasu Hirose, Ayumi Tsutsui, Robrecht Froyman, Carolin Ludwig, Johannes Koebberling, Hideaki Hanaki, Gerd Kleefeld, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Issue: 8 Pages: 878-887
- DOI
  10.1038/ja.2017.61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07866
[Journal Article] Nanaomycin H: A new nanaomycin analog2017
- Author(s)
  Takuji Nakashima, Toru Kimura, Rei Miyano, Hirotaka Matsuo, Tomoyasu Hirose, Aoi Kimishima, Kenichi Nonaka, Masato Iwatsuki, Jun Nakanishi, Yoko Takahashi and Satoshi Omura
- Journal Title
  
  Journal of Bioscience Bioengineering
  
  Volume: 123 Issue: 6 Pages: 765-770
- DOI
  10.1016/j.jbiosc.2017.01.011
- NAID
  40021226035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07866
[Journal Article] Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.2017
- Author(s)
  Hiroyasu Ando, Aoi Kimishima, Motoyoshi Ohara, Tomoyasu Hirose, Takanori Matsumaru, Hirokazu Takada, Keisuke Morodome, Takehiro Miyamoto, Akihiro Sugawara, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  J. Antibiot.
  
  Volume: 71 Issue: 2 Pages: 268-272
- DOI
  10.1038/ja.2017.77
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-16K08175, KAKENHI-PROJECT-15K07866
[Journal Article] Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: construction of a key linear intermediate2016
- Author(s)
  Jun Oshita, Yoshihiko Noguchi, Akito Watanabe, Goh Sennari, Shogo Sato, Tomoyasu Hirose, Daiki Oikawa, Yuki Inahashi, Masato Iwatsuki, Aki Ishiyama, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 57 Issue: 3 Pages: 357-360
- DOI
  10.1016/j.tetlet.2015.12.022
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-15J10769, KAKENHI-PROJECT-16K08174
[Journal Article] Organocatalytic Site-Selective Acylation of Avermectin B2a, a Unique Endectocidal Drug2016
- Author(s)
 Takeshi Yamada, Koh Suzuki, Tomoyasu Hirose, Takumi Furuta, Yoshihiro Ueda, Takeo Kawabata, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 64 Issue: 7 Pages: 856-864
- DOI
 10.1248/cpb.c16-00205
- NAID
 130005160046
- ISSN
 0009-2363, 1347-5223
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-16H01148, KAKENHI-PROJECT-26221301, KAKENHI-PROJECT-15K18827, KAKENHI-PROJECT-15K07866
[Journal Article] In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor2016
- Author(s)
 Toguchi Shohei, Hirose Tomoyasu, Yorita Kazuko, Fukui Kiyoshi, Sharpless K. Barry, Omura Satoshi, Sunazuka Toshiaki
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 64 Issue: 7 Pages: 695-703
- DOI
 10.1248/cpb.c15-00867
- NAID
 130005160055
- ISSN
 0009-2363, 1347-5223
- Language
 English
- Peer Reviewed / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-15K07866
[Journal Article] Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid.2016
- Author(s)
  Noguchi Yoshihiko, Hirose Tomoyasu, Ishiyama Aki, Iwatsuki Masato, Otoguro Kazuhiko, Sunazuka Toshiaki, Omura Satoshi
- Journal Title
  
  J. Nat. Med.
  
  Volume: 70 Issue: 3 Pages: 302-317
- DOI
  10.1007/s11418-016-1012-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07866
[Journal Article] The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-Pyridyl-Xanthones for Use as Insecticides Starting from Pyripyropene A2016
- Author(s)
  Shinichiro Fuse, Keisuke Matsumura, Kohei Johmoto, Hidehiro Uekusa, Hiroshi Tanaka, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura, Takashi Takahashi
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 51 Issue: 51 Pages: 18450-18455
- DOI
  10.1002/chem.201603980
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-16K08174
[Journal Article] Rapid Identification via In Situ Click Chemistry of a Novel Chitinase Inhibitor2016
- Author(s)
  Hirose Tomoyasu, Sunazuka Toshiaki, Omura Satoshi
- Journal Title
  
  Journal of Synthetic Organic Chemistry
  
  Volume: 74 Pages: 1090-1097
- NAID
  130005433321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07866
[Journal Article] Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase2015
- Author(s)
  Akihiro Sugawara, Nobuo Maita, Hiroaki Gouda, Tsuyoshi Yamamoto, Tomoyasu Hirose, Saori Kimura, Yoshifumi Saito, Hayato Nakano, Takako Kasai, Hirofumi Nakano, Kazuro Shiomi, Shuichi Hirono, Takeshi Watanabe, Hisaaki Taniguchi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 58 Issue: 12 Pages: 4984-4997
- DOI
  10.1021/acs.jmedchem.5b00175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-15K13747
[Journal Article] Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework2015
- Author(s)
  Takeshi Yamada, Tetsuya Ideguchi-Matsushita, Tomoyasu Hirose, Tatsuya Shirahata, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Akihiro Sugawara, Yoshinori Kobayashi, Kazuhiko Otoguro, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 21 Issue: 33 Pages: 11855-11864
- DOI
  10.1002/chem.201501150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-15K18836
[Journal Article] Jietacins with potent nematocidal activity; efficient isolation of novel analogues and divergent total synthesis of jietacin A, B, C, and D2015
- Author(s)
  4) Akihiro Sugawara, Masahiko Kubo, Takuji Nakashima, Tomoyasu Hirose, Noriaki Tsunoda, Kyoichi Yahagi, Yukihiro Asami, Takeshi Yamada, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 14 Pages: 2149-2157
- DOI
  10.1016/j.tet.2015.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019, KAKENHI-PROJECT-25460020, KAKENHI-PROJECT-26860015, KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-15K18836
[Journal Article] An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions.2015
- Author(s)
  Hayato Nakano, Akihiro Sugawara, Tomoyasu Hirose, Hiroaki Gouda, Shuichi Hirono, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 37 Pages: 000-000
- DOI
  10.1016/j.tet.2015.01.030
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PROJECT-24590019, KAKENHI-PROJECT-25460020, KAKENHI-PUBLICLY-26102737
[Journal Article] Organocatalytic α-Addition of Isocyanides to Aldehydes2015
- Author(s)
  Takeshi Yamada, Tomoyasu Hirose, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: 2015 Issue: 2 Pages: 296-301
- DOI
  10.1002/ejoc.201403313
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PROJECT-24590019, KAKENHI-PROJECT-25460020, KAKENHI-PROJECT-25860010, KAKENHI-PROJECT-15K18836
[Journal Article] A concise total synthesis of puberulic acid, potent antimalarial agent2014
- Author(s)
  Goh Sennari, Tomoyasu Hirose, Masato Iwatsuki, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Chem. Comm.
  
  Volume: 50 Issue: 63 Pages: 8715-8718
- DOI
  10.1039/c4cc03134b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Leucomycin A3, a 16-membered macrolide antibiotic, inhibits Influenza A virus infection and disease progression2014
- Author(s)
  Ryuichi Sugamata, Akihiro Sugawara, Tomokazu Nagao, Koya Suzuki, Tomoyasu Hirose, Ki-ichi Yamamoto, Masamichi Oshima, Kazuo Kobayashi, Toshiaki Sunazuka, Kiyoko S. Akagawa, Satoshi Omura, Toshinori Nakayama, and Kazuo Suzuki
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 67 Pages: 213-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Asymmetric Total Synthesis of Neoxaline2013
- Author(s)
  Tetsuya Ideguchi, Takeshi Yamada, Tatsuya Shirahata, Tomoyasu Hirose, Akihiro Sugawara, Yoshinori Kobayashi, Satoshi Omura, and Toshiaki Sunazuka
- Journal Title
  
  Journal of American Chemical Society
  
  Volume: 135 Pages: 12568-12571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening2013
- Author(s)
  Masaki Wakasugi, Hiroaki Gouda, Tomoyasu Hirose, Akihiro Sugawara, Tsuyoshi Yamamoto, Kazuro Shiomi, Toshiaki Sunazuka, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Pages: 3214-3220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Borrelidin analogues with antimalarial activity; design, synthesis and biological evaluation against Plasmodium falciparum parasites2013
- Author(s)
  Akihiro Sugawara, Toshiaki Tanaka, Tomoyasu Hirose, Aki Ishiyama, Masato Iwatsuki, Yoko Takahashi, Kazuhiko Otoguro, Satoshi Ōmura, Toshiaki Sunazuka
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Pages: 2302-2305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Antimalarial C-9 oxime derivatives from tylosin, produced by click chemistry2013
- Author(s)
  Ayumi Tsutsui, Tomoyasu Hirose, Aki Ishiyama, Masato Iwatsuki, Arisa Yokota, Hitomi Maruyama, Hidehito Matsui, Kazuhiko Otoguro, Hideaki Hanaki, Satoshi Ōmura and Toshiaki Sunazuka
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 66 Pages: 191-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Observation of the controlled assembly of preclick components in the In situ Click Chemistry generation of a chitinase inhibitor2013
- Author(s)
  Tomoyasu Hirose, Nobuo Maita, Hiroaki Gouda, Jun Koseki, Tsuyoshi Yamamoto, Akihiro Sugawara, Hirofumi Nakano, Kazuro Shiomi, Takeshi Watanabe, Hisaaki Taniguchi, K. Barry Sharpless, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Pages: 15892-15897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Structure determination and total synthesis of (+)-16-hydroxy-16,22-dihydroapparicine2013
- Author(s)
  Tomoyasu Hirose, Yoshihiko Noguchi, Yujiro Furuya, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 19 Pages: 10741-10750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Three-Dimensional Solution Structure of Bottromycin A2: A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci2012
- Author(s)
  Hiroaki Gouda, Yutaka Kobayashi, Takeshi Yamada, Tetsuya Ideguchi, Akihiro Sugawara, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Shuichi Hirono
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 2 Pages: 169-171
- DOI
  10.1248/cpb.60.169
- NAID
  130001852392
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-23890202
[Journal Article] Wickerols A and B: Novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-38492012
- Author(s)
  Tsuyoshi Yamamoto, Naoyuki Izumi, Hideaki Ui, Akito Sueki, Rokuro Masuma, Kenichi Nonaka, Tomoyasu Hirose, Toshiaki Sunazuka, Takayuki Nagai
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 9267-9271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16, 22-dihydroapparicine2012
- Author(s)
  Noguchi, Y.; Hirose, T.; Furuya, Y.; Ishiyama, A.; Otoguro, K.; Omura, S.; Sunazuka, T.
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53(14) Issue: 14 Pages: 1802-1807
- DOI
  10.1016/j.tetlet.2012.01.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590020, KAKENHI-PROJECT-22790017, KAKENHI-PLANNED-23105012
[Journal Article] A novel N-glucoside, Makomotindoline, from Makomotake, Zizania latifolia Infected with Ustilago esculenta2012
- Author(s)
  Tomohiro Suzuki, Jae-Hoon Choi, Takumi Kawaguchi, Kimiko Yamashita, Akio Morita, Hirofumi Hirai, Tomoyasu Hirose, Kaoru Nagai, Satoshi Omura, Toshiaki Sunazuka, Hirokazu Kawagishi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Pages: 4246-4248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Toward the total synthesis of luminamicin: construction of 14-membered lacton framework possessing versatile enol ether moiety2012
- Author(s)
  Aoi Kimishima, Tomoyasu Hirose, Akihiro Sugawara, Takanori Matsumaru, Kaoru Nakamura, Ken Katsuyama, Masaki Toda, Hirokazu Takada, Rokurou Masuma, Satoshi Ōmura, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 53 Pages: 2813-2816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; Synthesis, structure activity-relationships and in vivo study2012
- Author(s)
  Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S Akagawa, Satoshi Ōmura and Toshiaki Sunazuka
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 65 Pages: 487-490
- NAID
  10031044227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019
[Journal Article] Novel 12-membered non-antibiotic macrolides from erythromycin A ; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents2011
- Author(s)
  Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Kenichiro Nagai, Hiroaki Gouda, Shuichi Hirono, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21(11) Issue: 11 Pages: 3373-3376
- DOI
  10.1016/j.bmcl.2011.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag2011
- Author(s)
  T.Hirose, T.Kasai, T.Akimoto, A.Endo, A.Sugawara, K.Nagasawa, K.Shiomi, S.Omura, T.Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 35 Pages: 6633-6643
- DOI
  10.1016/j.tet.2011.05.073
- NAID
  130006995593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Tomoyasu Hirose, Kanami Iguchi, Noriyuki Yamaotsu, Akihiro Sugawara, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18 Pages: 5835-5844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790017
[Journal Article] Recent development of two chitinase inhibitor, Argifin and Argadin, produced by soil microorganisms2010
- Author(s)
  Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura
- Journal Title
  
  Proc.Jpn.Acad., Ser.B
  
  Volume: 86 Pages: 85-102
- NAID
  130000168766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790017
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Tomoyasu Hirose, Kanami Iguchi, Noriyuki Yamaotsu, Akihiro Sugawara, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18(16) Issue: 16 Pages: 5835-5844
- DOI
  10.1016/j.bmc.2010.06.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Bottromycin derivatives ; efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities2010
- Author(s)
  Yutaka Kobayashi, Maki Ichioka, Tomoyasu Hirose, Kenichiro Nagai, Atsuko Matsumoto, Hidehiro Matsui, Hideaki Hanaki, Rokuro Masuma, Yoko Takahashi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 20 Pages: 6116-6120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790017
[Journal Article] Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms2010
- Author(s)
  Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Omura
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 86 Issue: 2 Pages: 85-102
- DOI
  10.2183/pjab.86.85
- NAID
  130000168766
- ISSN
  0386-2208, 1349-2896
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790017
[Journal Article] Bottromycin derivatives efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities2010
- Author(s)
  Yutaka Kobayashi, Maki Ichioka, Tomoyasu Hirose, Kenichiro Nagai, Atsuko Matsumoto, Hidehiro Matsui, Hideaki Hanaki, Rokuro Masuma, Yoko Takahashi, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: Vol.20 Issue: 20 Pages: 6116-6120
- DOI
  10.1016/j.bmcl.2010.08.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790017
[Journal Article] Efficient total synthesis of novel bioactive microbial metabolites2008
- Author(s)
  Toshiaki Sunazuka, Tomoyasu Hirose, Satoshi Omura
- Journal Title
  
  Accounts of Chemical Research 41
  
  Pages: 302-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Design and synthesis via click chemistry of 8, 9-anhydroerythromycin A6, 9-hemiketal analogues with anti-MRSA and-VSE activity2007
- Author(s)
  Akihiro Sugawara, Toshiaki Sunazuka. Tomoyasu Hirose, Kenichiro Nagai, Yukie Yamaguchi, Hideaki Hanaki, K. Barry Sharpless, Satoshi Omura
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 17
  
  Pages: 6340-6344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Synthesis of the oxa-bridged octalin system of two anti-anaerobic antibiotics, luminamicin and lustromycin2007
- Author(s)
  Toshiaki Sunazuka, Masaki Handa, Tomoyasu Hirose, Takanori Matsumaru, Yuko Togashi, Kaoru Nakamura, Yuzuru Iwai, Satoshi Omura
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 5297-5300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Studies toward the total synthesis of irumamycin : stereoselective preparation of the C(15)-C(27) segment via two-directional chain synthesis2007
- Author(s)
  T.Hirose, T.Sunazuka, D.Yamamoto, M.Mouri, Y.Hagiwara, T.Matsumaru, E.Kaji, S.Omura
- Journal Title
  
  Tetrahedron Letters Vol. 48
  
  Pages: 413-416
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Total Synthesis and Biological Evaluation of Verticipyrone and Analogues2007
- Author(s)
  H.Shimamura, T.Sunazuka, T.Izuhara, T.Hirose, K.Shiomi, S.Omura
- Journal Title
  
  Organic Letters Vol. 9 No. 1
  
  Pages: 65-67
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] RAPID 'SAR' VIA CLICK CHEMISTRY : AN ALKYNE-BEARING SPIRAMYCIN IS FUSE WITH DIVERSE AZIDES TO YIELD NEW TRIAZOLE-ANTIBACTERIAL CANDIDATES2006
- Author(s)
  T.Hirose, T.Sunazuka, Y.Noguchi, Y.Yamaguchi, H.Hanaki, K.B.Sharpless, S.Omura
- Journal Title
  
  Heterocycles Vol. 69
  
  Pages: 55-61
- NAID
  40015163880
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Synthetic applications of a three-component Mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B.2006
- Author(s)
  T.Hirose, T.Sunazuka, D.Yamamoto, E.Kaji, S.Omura
- Journal Title
  
  Tetrahedron Letters Vol. 47
  
  Pages: 6761-6764
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Design, synthesis, and biological activities of madindoline analogues.2006
- Author(s)
  D.Yamamoto, T.Sunazuka, T.Hirose, N.Kojima, E.Kaji, S.Omura
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry Letters Vol. 16
  
  Pages: 2807-2811
- Data Source
  KAKENHI-PROJECT-18790022
[Journal Article] Asymmetric Total Synthesis of (+)-KO1-0509 B : Determination of Absolute Configuration2006
- Author(s)
  S.Tsuchiya, T.Sunazuka, T.Hirose, R.Mori, T.Tanaka, M.Iwatsuki, S.Omura
- Journal Title
  
  Organic Letters Vol. 8 No. 24
  
  Pages: 5577-5580
- Data Source
  KAKENHI-PROJECT-18790022
[Presentation] ODTAA誘導体とin situ click chemistryを用いた新規MBL阻害剤創製研究2024
- Author(s)
  鈴木智博、池田朱里、本庄雅子、野口吉彦、中里貴々、富山昂大、池谷佳紀、浅見行弘、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] モジュラー型アプローチによるイベルメクチンの全合成研究2024
- Author(s)
  小川昌也、千成恒、齋藤亮、佐藤翔悟、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新規IPP阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究2024
- Author(s)
  鈴木大貴、金井田將裕、千成恒、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 爪白癬症治療薬を指向したナフトキノン類誘導体の創薬研究2024
- Author(s)
  野口吉彦、有馬直明、酒井一成、安部一豊、佐々木健、扇谷忠明、廣瀬友靖、砂塚敏明、花木秀明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 抗マラリア活性を有するメロテルペノイド類の全合成研究2024
- Author(s)
  岩堀雅大、千成恒、木村奏一朗、渡辺善洋、岩月正人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 微生物培養液からの灰色かび病を標的とした農薬シードの探索2024
- Author(s)
  濱田華凜、薊はるき、渡邊善洋、小島裕貴、常盤俊之、野中健一、稲橋佑起、五島剛太、廣瀬友靖、砂塚敏明、弓削秀隆、岩月正人
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] イベルメクチン結合因子の同定とWnt/β-catenin経路制御機能の解析2024
- Author(s)
  米澤穂波、大森紀和、池田朱里、廣瀬友靖、岩月正人、砂塚敏明、上原至雅、西谷直之
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 環状ペプチド化による新規傾向マラリア薬創製研究2024
- Author(s)
  吉岡修志、池田朱里、野口吉彦、上田あかり、林裕美、穂苅玲、岩月正人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 抗トリパノソーマ活性を有するActinoallolide類の全合成研究2024
- Author(s)
  寺内航、渡邉彰人、野口吉彦、稲橋佑起、岩月正人、石山亜紀、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 抗インフルエンザ活性を有するwickerol類の全合成研究2024
- Author(s)
  宮田拓真、千成恒、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 4連続したセリン残基をもつ環状デプシペプチドFKJ-0225の液相全合成2024
- Author(s)
  中原大生、薊はるき、野口吉彦、千成恒、渡邉善洋、堤隼馬、稲橋佑起、岩月正人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] N-担持型疎水性タグの開発：固相-液相リレー合成によるcalpinactamの全合成2023
- Author(s)
  中原大生、千成恒、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  第56回　天然物化学談話会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] A new analog of dihydroxybenzoic acid from Rare actinomycetes, Saccharopolyspora sp. KR21-00012023
- Author(s)
  Rattiya Janthanom, Yuta Kikuchi, Tomoyasu Hirose, Arinthip Thamchaipenet, Yuki Inahashi
- Organizer
  International Conference of the Genetics Society of Korea 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新規PPI阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究-22023
- Author(s)
  金井田將裕、鈴木大貴、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] PIKKs安定化因子TELO2はイベルメクチンによるWnt/β-catenin経路阻害作用を仲介する2023
- Author(s)
  米澤穂波、池田朱里、高橋亮、廣瀬友靖、岩月正人、砂塚敏明、上原至雅、西谷直之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 無水マレイン酸とポリケタイド骨格を特徴としたルミナミシンの生合成研究2023
- Author(s)
  鈴木澪央那、石井皓大、小牧彩乃、山川結加、堤隼馬、廣瀬友靖、砂塚敏明、稲橋佑起
- Organizer
  2023年度（第37回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K06184
[Presentation] ODTAA誘導体を基盤とした新規MBL阻害剤創製研究2023
- Author(s)
  鈴木智博、池田朱里、本庄雅子、野口吉彦、中里貴々、冨山昴大、池谷佳紀、浅見行弘、廣瀬友靖、砂塚敏明
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然物をターゲットとした効率的全合成と有用生物活性物質のリード探索2023
- Author(s)
  廣瀬友靖
- Organizer
  有機合成化学関東支部ミニシンポジウム千葉2023
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] マラリア薬創製を指向した環状ペプチドライブラリーの構築法の確立2023
- Author(s)
  吉岡修志、池田朱里、野口吉彦、上田あかり、林裕美、穂苅玲、岩月正人、廣瀬友靖、砂塚敏明
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 無水マレイン酸とポリケタイド骨格を特徴としたルミナミシンの生合成研究2023
- Author(s)
  鈴木澪央那、堤隼馬、石井皓大、小牧彩乃、山川結加、廣瀬友靖、砂塚敏明、稲橋佑起
- Organizer
  第37回日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] N-担持型疎水性タグの開発：固相-液相リレー合成によるcalpinactamの全合成2023
- Author(s)
  中原大生、千成恒、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本プロセス化学会2023サマーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] Oxidative stress in Schistosoma mansoni schistosomula treated with a quinone compound from Omura natural compound library.2023
- Author(s)
  Kofi Dadzie KWOFIE, Akari IKEDA, Yoshihiko NOGUCHI, Hayato KAWADA, Fusako MIKAMI, Rei HOKARI, Yoshihiro WATANABE, Dorothy YEBOAH-MANU, Irene AYI, Samuel Kweku DADZIE, Tomoyasu HIROSE, Masato IWATSUKI, Toshiaki SUNAZUKA, Naotoshi TSUJI, Takeshi HATTA
- Organizer
  グローバルヘルス合同大会2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新規 PPI 阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究2023
- Author(s)
  鈴木大貴、金井田將裕、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] IMP-1型Metallo-β-lactamaseの構造解析に向けた取り組み2023
- Author(s)
  須川龍、喜多俊介、池田朱里、本庄雅子、浅見行弘、砂塚敏明、廣瀬友靖、前仲勝実
- Organizer
  生命分子科学研究会 Biomolecular Science NISEKO MEETING
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新規PPI阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究-12023
- Author(s)
  鈴木大貴、金井田將裕、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] ペプチド伸長戦略を拡張するN-担持型疎水性Tag“TCbz”の開発2023
- Author(s)
  中原大生、野口吉彦、千成恒、関怜子、長井賢一郎、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然物を基盤とした中分子創薬研究における合成展開2023
- Author(s)
  廣瀬友靖、岩月正人、砂塚敏明
- Organizer
  日本薬学会第143年会　シンポジウム「中分子創薬が直面する課題とその克服に向けて」
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] ポットエコノミーを指向した生物活性環状デプシペプチド類の疎水性タグ合成2023
- Author(s)
  野口吉彦、関川章悟、野垣祐貴、佐竹雄大、村島徳史、桐沢貴志、Schiffer Guido、Koebberling Johannes、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] In situ click chemistryによる新規メタロ-β-ラクタマーゼ阻害剤の探索研究2023
- Author(s)
  池田朱里、中里貴々、冨山昂大、池谷佳紀、本庄雅子、浅見行弘、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然物を基盤とした構造展開と創薬リード探索2022
- Author(s)
  廣瀬友靖
- Organizer
  BINDSセミナー（北海道大学）
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新規PPI阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究2022
- Author(s)
  金井田將裕、野口吉彦、鈴木大貴、廣瀬友靖、砂塚敏明
- Organizer
  第121回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 抗嫌気性菌活性を有するマクロジオライドluminamicinのリレー全合成研究2022
- Author(s)
  君嶋葵、安藤博康、関川章悟、小嶋透、大原基義、渡邉善洋、稲橋佑起、高田拓和、菅原章公、松丸尊紀、千成恒、野口吉彦、岩月正人、廣瀬友靖、砂塚敏明
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然化合物を基盤としたin situ click chemistryの展開2022
- Author(s)
  廣瀬友靖
- Organizer
  第34回ケムステVシンポ「日本のクリックケミストリー」
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 座間味島由来糸状菌 Mariannaea sp. FKR-1011株が生産する新規ジテルペノイドピロ；Novel Diterpenoid Pyrones from Fermentations of Mariannaea sp. FKR-1011 from Zamami Island2022
- Author(s)
  若月美佑、和田将弘、野中健一、渡邊善洋、廣瀬友靖、本庄雅子、浅見行弘、岩月正人、松井秀仁、砂塚敏明、花木秀明、照屋俊明、石井貴広
- Organizer
  第66回香料・テルペンおよび精油化学に関する討論会（TEAC）
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然物をターゲットとした効率的全合成と有用生物活性物質のリード探索2022
- Author(s)
  廣瀬友靖
- Organizer
  筑波大学理工学群化学類＆筑波大学大学院数理物質科学研究群化学学位プログラム第４回有機化学・創薬化学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 大村天然物をターゲットとした効率的全合成と有用生物活性物質のリード探索2022
- Author(s)
  廣瀬友靖
- Organizer
  第66回日本薬学会関東支部大会シンポジウム「薬学の未来を拓く有機化学」
- Invited
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] Total Syntheses and Chemical Biology Studies of Hymeglusin and Fusarilactone A, Novel Circumventors of β-Lactam Drug Resistance in MRSA2022
- Author(s)
  Masahiro Kanaida, Aoi Kimishima, Shuhei Eguchi, Masato Iwatsuki, Yoshihiro Watanabe, Masako Hosho, Yoshihiko Noguchi, Kenichi Nonaka, Goh Sennari, Hidehito Matsui, Chikara Kaito, Hideaki Hanaki, Yukihiro Asami, Tomoyasu Hirose, Toshiaki Sunazuka
- Organizer
  次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06535
[Presentation] 新たな疎水性アンカー分子を用いた抗マラリア活性リポペプチドKozupeptin Aの合成及び構造活性相関研究2021
- Author(s)
  上田あかり、廣瀬友靖、林裕美、岩月正人、穗苅玲、石山亜紀、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 環状デプシペプチド類の効率的合成を志向した疎水性タグのワンポット化2021
- Author(s)
  関川章悟、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] MEPM耐性克服活性を示す新規Hymeglusin類縁体の単離と不斉全合成2021
- Author(s)
  金井田將裕、君嶋葵、江口修平、岩月正人、野中健一、松井秀仁、花木秀明、浅見行弘、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 無水マレイン酸とポリケタイド骨格を特徴としたluminamicinの生合成研究2021
- Author(s)
  石井皓大, 小牧彩乃, 関川章悟, 小嶋透, 堤隼馬, 廣瀬友靖, 砂塚敏明, 稲橋佑起
- Organizer
  2021年度日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-20K07105
[Presentation] Ⅲ型分泌装置(T3SS)阻害活性を有するAurodoxの全合成研究2021
- Author(s)
  大原基義、池田朱里、中嶋明日香、大野孝典、野口吉彦、渡邊彰人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2021
- Author(s)
  大野孝典、野口吉彦、渡邊彰人、岩月正人、稲橋佑起、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] メタロ-β-ラクタマーゼ阻害物質ODTAAの構造活性相関研究2021
- Author(s)
  中里貴々、池田朱里、冨山昴大、池谷佳紀、本庄雅子、浅見行弘、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成2021
- Author(s)
  小嶋透、安藤博康、君嶋葵、大原基義、稲橋佑起、岩月正人、渡邊善洋、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有するDiatretolの不斉全合成と構造活性相関研究2021
- Author(s)
  高橋脩、君嶋葵、山田健、菅原章弘、白畑辰弥、野口吉彦、岩月正人、穗苅玲、石山亜紀、小林義典、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規抗マラリア薬開発を指向したPuberulic acid類の構造活性相関研究2021
- Author(s)
  中嶋明日香、齋藤亮、千成恒、岩月正人、石山亜紀、穗苅玲、乙黒一彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2020
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究2020
- Author(s)
  安藤博康、小嶋透、君嶋葵、大原基義、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規疎水性アンカー分子を用いたKozupeptin A前駆体抗マラリア活性ペプチドアルデヒドの効率的合成法の開発2020
- Author(s)
  林裕美、廣瀬友靖、岩月正人、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] イベルメクチン結合タンパク質(IvBP)はdruggableなWnt/β-catenin経路仲介因子である2020
- Author(s)
  米澤穂波、池田朱里、高橋亮、廣瀬友靖、岩月正人、大村智、砂塚敏明、上原至雅、西谷直之
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマ活性を有するアクチノアロライドAの全合成研究 -12員環ラクトンの骨格構築-2020
- Author(s)
  渡邊彰人、野口吉彦、大西倫、廣瀬友靖、岩月正人、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗感染症薬を指向した　3Z,5E-octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride(ODTAA)の全合成と構造活性相関研究2019
- Author(s)
  池谷佳紀、廣瀬友靖、浅見行弘、松井秀仁、野口吉彦、花木秀明、塩見和朗、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するLuminamicinのリレー全合成研究2019
- Author(s)
  小嶋透、君嶋葵、大原基義、安藤博康、松本厚子、岩月正人、渡邊善洋、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するルミナミシンのリレー全合成と構造活性相関研究2019
- Author(s)
  大原基義、君嶋葵、安藤博康、廣瀬友靖、野中健一、松本厚子、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] メロペネム耐性克服活性を示すヒメグルシン類の不斉全合成2019
- Author(s)
  金井田將裕、君嶋葵、廣瀬友靖、江口修平、渡邊善洋、岩月正人、浅見行弘、塩見和朗、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2019
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] コンビナトリアルライブラリーの構築を指向したエバーメクチン類の全合成研究2019
- Author(s)
  齋藤亮、君嶋葵、千成恒、佐藤翔悟、廣瀬友靖、増井悠、高橋孝志、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] Utilization of Hydrophobic TAGs for Synthesis of Unique Peptide Natural Products2019
- Author(s)
  廣瀬友靖
- Organizer
  Gordon Research Conference, Natural Products and Bioactive Compounds
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規抗マラリア活性リポペプチド kozupeptin A の実用的全合成、絶対立体構造の決定および抗マラリア活性の評価2019
- Author(s)
  林裕美、廣瀬友靖、深澤航、岩月正人、穂苅玲、石山亜紀、野中健一、塩見和朗、大村智、砂塚敏明
- Organizer
  第115回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] コンビナトリアルライブラリーの構築を指向したエバーメクチン類の全合成研究2019
- Author(s)
  齋藤亮、君嶋葵、中嶋明日香、千成恒、佐藤翔悟、廣瀬友靖、増井悠、高橋孝志、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有する(+)-Diatretolの不斉全合成2019
- Author(s)
  高橋脩、廣瀬友靖、君嶋葵、岩月正人、穂苅玲、石山亜紀、山田健、菅原章公、大村智、砂塚敏明
- Organizer
  第116回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有するDiatretolの不斉全合成と網羅的構造活性相関研究2019
- Author(s)
  高橋脩、廣瀬友靖、君嶋葵、岩月正人、穂苅玲、石山亜紀、山田健、菅原章公、佐藤達彦、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] コンビナトリアルライブラリー構築を指向したエバーメクチン類の全合成研究2019
- Author(s)
  齋藤亮、君嶋葵、千成恒、佐藤翔悟、廣瀬友靖、増井悠、高橋孝志、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規抗マラリア薬開発を指向したプベルリックアシッド類の構造活性相関研究2019
- Author(s)
  中嶋明日香、齋藤亮、千成恒、廣瀬友靖、君嶋葵、岩月正人、石山亜紀、穂苅玲、乙黒一彦、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有するジアトレトールの不斉全合成2019
- Author(s)
  高橋脩、廣瀬友靖、君嶋葵、岩月正人、石山亜紀、山田健、菅原章公、穂苅玲、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究；10員環ラクトンの構築2019
- Author(s)
  安藤博康、大原基義、君嶋葵、廣瀬友靖、金井田將裕、宮本岳洋、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 疎水性タグを用いた環状デプシペプチド類の全合成2019
- Author(s)
  野口吉彦、桐沢貴志、野垣祐貴、廣瀬友靖、村島徳史、佐竹雄大、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] インフルエンザ重症化予防薬創製を指向したピルビン酸脱水素酵素キナーゼ4(PDK4)阻害剤の合成研究2019
- Author(s)
  冨山昂大、池田朱里、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規抗マラリア薬開発を指向したPuberulic acid類の構造活性相関研究2019
- Author(s)
  中嶋明日香、齋藤亮、千成恒、廣瀬友靖、岩月正人、石山亜紀、穂苅玲、乙黒一彦、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性活性を有するルミナミシンのリレー全合成研究2019
- Author(s)
  小嶋透、君嶋葵、大原基義、安藤博康、松本厚子、岩月正人、渡邊善洋、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有するkozupeptin類の単離、構造決定、全合成および活性評価2019
- Author(s)
  林裕美、廣瀬友靖、深澤航、岩月正人、穂苅玲、石山亜紀、野中健一、塩見和朗、大村智、砂塚敏明
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有するkozupeptin類の単離、構造決定、全合成および活性評価2019
- Author(s)
  林裕美、廣瀬友靖、深澤航、岩月正人、穗苅玲、石山亜紀、野中健一、塩見和朗、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] メロペネム耐性克服活性を示すヒメグルシン類の創薬研究2019
- Author(s)
  金井田将裕、君嶋葵、廣瀬友靖、江口修平、渡邊善洋、岩月正人、浅見行弘、塩見和朗、砂塚敏明、大村智
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 新規抗マラリア活性リポペプチドKozupeptin Aの実用的全合成および絶対立体構造の決定2019
- Author(s)
  林裕美、廣瀬友靖、深澤航、岩月正人、野中健一、穂苅玲、石山亜紀、塩見和朗、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマ活性を有するアクチノアロライド Aの全合成研究2019
- Author(s)
  大西倫、野口吉彦、渡邊彰人、岩月正人、稲橋佑起、石山亜紀、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] エバーメクチンの新作用探索を指向したケミカルツールの合成研究2019
- Author(s)
  高橋亮、池田朱里、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性を有する(+)-Diatretolの不斉全合成2019
- Author(s)
  高橋脩、廣瀬友靖、君嶋葵、岩月正人、穂苅玲、石山亜紀、山田健、菅原章公、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマ活性を有するアクチノアロライドAの全合研究 -12員環ラクトンの骨格構築-2019
- Author(s)
  渡邊彰人、野口吉彦、大西倫、岩月正人、稲橋佑起、石山亜紀、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究2019
- Author(s)
  安藤博康、小嶋透、君嶋葵、大原基義、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 疎水性タグを用いた環状デプシペプチド類の全合成2019
- Author(s)
  野口吉彦、野垣祐貴、廣瀬友靖、村島徳史、佐竹雄大、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] インフルエンザ重症化予防薬創製を指向したピルビン酸脱水素酵素キナーゼ4(PDK4)阻害剤の合成研究2019
- Author(s)
  冨山昴大、池田朱里、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマを有するActinoallolide Aの全合成研究2019
- Author(s)
  渡邊彰人、野口吉彦、大西倫、廣瀬友靖、岩月正人、稲橋佑起、大村智、砂塚敏明
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2019
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第11回　北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 疎水性タグを用いた殺虫活性を示す24員環デプシペプチドVerticilideの全合成2018
- Author(s)
  野口吉彦、廣瀬友靖、佐竹雄大、村島徳史、野垣祐貴、塩見和朗、大村　智、砂塚敏明
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 薬剤感受性出芽酵母を用いた微生物二次代謝産物からの抗真菌薬シード化合物の探索2018
- Author(s)
  坂井克行，廣瀬友靖，岩月正人、知念拓実、木村徹、須賀拓弥，野中健一、中島琢自、砂塚敏明、臼井健郎，浅見行弘、大村智、塩見和朗
- Organizer
  第101回日本細菌学会関東支部総会
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2018
- Author(s)
  渡邊彰人、野口吉彦、廣瀬友靖、佐藤翔悟、千成恒、岩月正人、稲橋佑起大村智、砂塚敏明
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 大村天然物をターゲットとした効率的全合成と有用生物活性物質のリード探索2018
- Author(s)
  廣瀬友靖
- Organizer
  岩手医科大薬学部セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06586
[Presentation] 抗マラリア活性トロポノイド類の多様性指向型合成と構造活性相関研究2018
- Author(s)
  千成恒、齋藤亮、廣瀬友靖、岩月正人、石山亜紀、穂刈　玲、乙黒一彦、大村智、砂塚敏明
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗マラリア活性を有するPuberulic acid類の全合成と構造活性相関研究2017
- Author(s)
  齋藤亮、千成恒、廣瀬友靖、岩月正人、石山亜紀、穂刈玲、乙黒一彦、大村智、砂塚敏明
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] Progress toward the total synthesis of Actinoallolide A, potent anti-trypanosomal macrolide2017
- Author(s)
  渡邊彰人、野口吉彦、佐藤翔悟、千成恒、岩月正人、稲橋佑起、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第112回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究2017
- Author(s)
  安藤博康、大原基義、宮本岳洋、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第112回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] アゾキシ天然物 Jietacin のバイオイソスターを考慮した類縁体の合成2017
- Author(s)
  菅原章公、久保雅彦、廣瀬友靖、矢作恭一、Claudia WELZ、Cristina MERTENS、Johannes KOBBERLING、中島琢自、高橋洋子、大村智、砂塚敏明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 嫌気性菌活性を有するルミナミシンの全合成研究 ;三置換オレフィンを含むサザンパートの合成2017
- Author(s)
  安藤博康、菅原章公、廣瀬友靖、大原基義、君嶋葵、高田拓和、大村智、砂塚敏明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] コンビナトリアルライブラリーの構築を指向したエバーメクチン類の全合成研究 ; ファーマコフォアフラグメントの合成2017
- Author(s)
  千成恒、廣瀬友靖、増井悠、高橋孝志、大村智、砂塚敏明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有するマングロマイシン類の単離、構造決定ならびに不斉全合成2017
- Author(s)
  廣瀬友靖、中島琢自、高田拓和、岩月正人、山田健、落合純也、神谷義之、石原拓真、長井賢一郎、松本厚子、石山亜紀、乙黒一彦、塩見和朗、高橋洋子、砂塚敏明、大村智
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有するMangromicin Aの全合成と絶対立体構造の決定2017
- Author(s)
  高田拓和、山田健、廣瀬友靖、石原拓真、中島琢自、高橋洋子、大村智、砂塚敏明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有する Actinoallolide A の全合成研究2017
- Author(s)
  渡邊彰人、野口吉彦、廣瀬友靖、佐藤翔悟、千成恒、岩月正人、稲橋佑起大村智、砂塚敏明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 薬作りへの有機分子触媒の活用2016
- Author(s)
  砂塚敏明、山田健、廣瀬友靖、大村智
- Organizer
  第6回CSJ化学フェスタ2016
- Place of Presentation
  東京（タワーホール船堀）
- Year and Date
  2016-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 有機分子触媒を用いたイソシアニドとアルデヒドのα-付加反応2016
- Author(s)
  山田健、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第110回有機合成シンポジウム2016年【秋】
- Place of Presentation
  東京（早稲田大学国際会議場）
- Year and Date
  2016-11-10
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗嫌気性菌活性を有するLuminamicinの全合成研究2016
- Author(s)
  安藤博康、君嶋葵、高田拓和、諸留圭介、松丸尊紀、菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第109回有機合成シンポジウム
- Place of Presentation
  東京（東京工業大学大岡山キャンパス）
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] Utilization of in situ click chemistry to discover novel chitinase inhibitors2016
- Author(s)
  Tomoyasu Hirose, Nobuo Maita, Takeshi Watanabe, Hisaaki Taniguchi, K. Barry Sharpless, Satoshi Omura and Toshiaki Sunazuka
- Organizer
  25th French-Japanese Symposium on Medicinal and Fine Chemistry (FJS 2016)
- Place of Presentation
  Keio Plaza Hotel Tama, Japan
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有する新規マクロライド、Actinoallolide類の全合成研究2016
- Author(s)
  渡邊彰人、大下純、野口吉彦、及川大輝、廣瀬友靖、稲橋正人、稲橋佑起、大村智、砂塚敏明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 顧みられない熱帯病、トリパノソーマ症に有効なマングロマイシン類の全合成研究2016
- Author(s)
  高田拓和、山田健、廣瀬友靖、石原拓真、中島琢自、高橋洋子、大村智、砂塚敏明
- Organizer
  第110回有機合成シンポジウム2016年【秋】
- Place of Presentation
  東京（早稲田大学国際会議場）
- Year and Date
  2016-11-10
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2016
- Author(s)
  渡邊彰人、大下純、野口吉彦、及川大揮、岩月正人、稲橋佑起、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第109回有機合成シンポジウム
- Place of Presentation
  東京（東京工業大学大岡山キャンパス）
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2015
- Author(s)
  渡邊彰人、大下純、野口吉彦、及川大輝、岩月正人、稲橋佑起、廣瀬友靖、大村智、砂塚敏明
- Organizer
  AKPS集会第9回北里化学シンポジウム
- Place of Presentation
  北里大学白金キャンパス、東京都港区
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2015
- Author(s)
  渡邊彰人、大下純、野口吉彦、及川大輝、岩月正人、稲橋佑起、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部、千葉県船橋市
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] Determination of absolute stereochemistry and toward the total synthesis of actinoallolides, new anti-trypanosomal macrolides, produced by an endophytic actinomycete2015
- Author(s)
  T. Hirose, J. Oshita, D. Oikawa, Y. Inahashi, M. Iwatsuki, A. Matsumoto, S. Omura and T. Sunazuka
- Organizer
  ICCA-14
- Place of Presentation
  Texas, USA
- Year and Date
  2015-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07866
[Presentation] 標的酵素誘導型トリアゾール化を利用した天然物創薬研究2014
- Author(s)
  廣瀬友靖
- Organizer
  第15回酵素応用シンポジウム
- Place of Presentation
  名古屋市、天野エンザイム（株）慈善ホール
- Year and Date
  2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 抗マラリア活性を有するPuberulic acid類の多様性指向型合成2014
- Author(s)
  千成恒、廣瀬友靖、岩月正人、石山亜紀、乙黒一彦、大村智、砂塚　敏明
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県（熊本大学）
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 構造活性相関研究を志向したBottromycin A2類の合成2014
- Author(s)
  八木田美有、山田健、堀松優樹、小林豊、千成恒、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京都町田市、昭和薬科大学
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] クリックケミストリーにより広がる天然有機化合物の活用2014
- Author(s)
  廣瀬友靖
- Organizer
  創薬資源微生物学、寄附講座開設記念シンポジウム
- Place of Presentation
  東京都、北里大学　白金キャンパス
- Year and Date
  2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 天然物を基盤としたin situ click chemistry2013
- Author(s)
  廣瀬友靖
- Organizer
  有機合成化学ミニシンポジウム
- Place of Presentation
  東京都（北里大学白金キャンパス)
- Invited
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] Total synthesis of Puberulic Acid, a potent antimalarial2013
- Author(s)
  Goh Sennari, Tomoyasu Hirose, Masato Iwatsuki, Aki Ishiyama, Kazuhiko Otoguro, Satoshi Omura, and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  山梨県（富士ビューホテル）
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] インドリンスピロアミナール骨格を有するNeoxalineの全合成2013
- Author(s)
  井手口哲也、山田健、白畑辰弥、廣瀬友靖、菅原章公、小林義典、大村智、砂塚敏明
- Organizer
  第11回次世代を担う有機合成シンポジウム
- Place of Presentation
  東京都（日本薬学会長井記念ホール）
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] Asymmetric Total Synthesis of Neoxaline2013
- Author(s)
  Tetsuya Ideguchi, Takeshi Yamada, Tatsuya Shirahata, Tomoyasu Hirose, Akihiro Sugawara, Yoshinori Kobayashi, Satoshi Omura and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  山梨県（富士ビューホテル）
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] ベンジル系疎水性タグを利用した親水性天然物アージフィンの液相全合成2012
- Author(s)
  廣瀬友靖, 笠井尚子, 秋元隆史, 遠藤綾子, 菅原章公, 長澤和夫, 大村智, 砂塚敏明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌(北海道大学)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] 天然物を基にした特異的かつ強力なキチナーゼ阻害剤の創製研究2011
- Author(s)
  廣瀬友靖
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  習志野(東邦大学習志野キャンパス)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] In Situクリックケミストリーを利用した生物活性天然物からの創薬研究2011
- Author(s)
  廣瀬友靖
- Organizer
  第3回全国利用・共同研究「酵素学拠点」シンポジウム
- Place of Presentation
  徳島(徳島大学長井記念ホール)(招待講演)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] In Situクリックケミストリーを利用した生物活性天然物からの創薬研究2011
- Author(s)
  廣瀬友靖
- Organizer
  第3回全国利用・共同研究「酵素学拠点」シンポジウム～酵素学から始まる新たな創薬研究～
- Place of Presentation
  徳島(徳島大学長井記念ホール)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] 天然物を基にした特異的かつ強力なキチナーゼ阻害剤の創製研究2011
- Author(s)
  廣瀬友靖
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  習志野(東邦大学習志野キャンパス)(招待講演)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] Type III分泌機構阻害活性を有するGuadinomine類の不斉全合成と絶対立体構造決定2011
- Author(s)
  廣瀬友靖、土屋智史、森龍真、田中利知、小嶋康裕、岩月正人、高橋洋子、大村智、砂塚敏明
- Organizer
  第4回有機触媒シンポジウム
- Place of Presentation
  東京(東京理科大学神楽坂キャンパス)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] Extraction of the active framework from natural argifin and use of in situ click chemistry2011
- Author(s)
 Tomoyasu Hirose, et al
- Organizer
 242^<nd> ACS National Meeting
- Place of Presentation
 Denver, Colorado, USA
- Data Source
 KAKENHI-PROJECT-22790017
[Presentation] 疎水性タグを用いたキチナーゼ阻害剤Argifinの液相全合成2011
- Author(s)
  廣瀬友靖、笠井尚子、秋元隆史、遠藤綾子、菅原章公、長澤和夫、塩見和朗、大村智、砂塚敏明
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島(あわぎんホール)
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] Argifinの全合成と高活性キチナーゼ阻害剤の創製研究2010
- Author(s)
  廣瀬友靖
- Organizer
  第3回日本薬学会関東支部若手シンポジウム
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] Argifinの全合成と高活性キチナーゼ阻害剤の創製研究2010
- Author(s)
  廣瀬友靖
- Organizer
  第3回日本薬学会関東支部若手シンポジウム
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] First total synthesis and determination of absolute configuration of guadinomines2007
- Author(s)
  Tomoyasu Hirose, Toshiaki Sunazuka and Satoshi Omura
- Organizer
  Symposium on Chemistry and Biology of Bioactive Natural Products
- Place of Presentation
  ドイツ、Kaiserslautern
- Data Source
  KAKENHI-PROJECT-18790022
[Presentation] Chitinase inhibitors : Extraction of the active framework from natural argifin and use of in situ click chemistry2001
- Author(s)
  Tomoyasu Hirose, Akihiro Sugawara, Ayako Endo, Tsuyoshi Yamamoto, Kzuro Shiomi, Takeshi Watanabe, K. Barry Sharpless, Satoshi Omura, Toshiaki Sunazuka
- Organizer
  242nd American Chemical Society National Meeting
- Place of Presentation
  Denver, Colorado, USA
- Data Source
  KAKENHI-PROJECT-22790017
[Presentation] In situクリックケミストリーを利用した高活性キチナーゼ阻害剤の探索研究
- Author(s)
  廣瀬友靖
- Organizer
  平成26年度大会（第63回）応用糖質科学シンポジウム
- Place of Presentation
  新潟市、朱鷺メッセ新潟コンベンションホール
- Year and Date
  2014-09-24 – 2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 創薬展開を志向したBottromycin A2の構造活性相関研究
- Author(s)
  八木田美有、小林豊、山田健、堀松優樹、廣瀬友靖、花木秀明、大村智、砂塚敏明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市、神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] インドリンスピロアミナール骨格を有するNeoxaline類の効率的な全合成
- Author(s)
  井手口哲也、山田健、白畑辰弥、廣瀬友靖、菅原章公、小林義典、大村智、砂塚敏明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市、神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 有機分子触媒を用いたイソシアニドとアルデヒドのα-付加反応
- Author(s)
  山田健、廣瀬友靖、大村智、砂塚敏明
- Organizer
  有機分子触媒による未来型分子変換、第4回公開シンポジウム
- Place of Presentation
  北海道札幌市、北海道大学
- Year and Date
  2014-06-20 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] 抗嫌気性菌活性を有するLuminamicinの合成研究
- Author(s)
  君嶋葵、諸留圭介、高田拓和、松丸尊紀、菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市、神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590019
[Presentation] インドリンスピロアミナール骨格を有するNeoxaline類の全合成
- Author(s)
  井手口哲也、山田健、白畑辰弥、廣瀬友靖、菅原章公、小林義典、大村智、砂塚敏明
- Organizer
  第105回有機合成シンポジウム
- Place of Presentation
  東京都、東京工業大学、大岡山キャンパス
- Year and Date
  2014-06-10 – 2014-06-11
- Data Source
  KAKENHI-PROJECT-24590019

1. 松井秀仁 (80503797)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Inahashi Yuki (70645522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Aki Ishiyama (70300746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IWATSUKI MASATO (70353464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. MATSUMOTO ATSUKO (20300759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NONAKA KENICHI (60421369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IKADAI HIROMI (80327460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 西谷直之 (10286867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MURAI Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. YAMADA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. DOMON Hisanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. KAZURO Shiomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 渡邊善洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 砂塚敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
15. 福島健介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 石井貴広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 合田浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 山乙教之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 広野修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hirose Tomoyasu 廣瀬 友靖

HIROSE Tomoyasu 廣瀬 友靖

廣瀬 友靖 ヒロセ トモヤス

Research Projects

Research Products

Co-Researchers

抗嫌気性菌活性を示す微生物由来２環性デプシペプチドを標的とした全合成と創薬研究Principal Investigator

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生体高分子認識構造α-solenoidを標的とした中分子創薬の基盤構築

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Clostridioides difficileに対する芽胞形成阻害物質の探索と作用機構解析

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ルミナミシンの生合成経路解明とC. difficile感染症治療薬への応用

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ライブラリー指向型イベルメクチン全合成法の確立と誘導体創製研究Principal Investigator

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Producing the luminamicin analogs by genetic engineering

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Total synthesis of 10-14 membered ring fused dimacrolides, potent narrow antimicrobial activitiesPrincipal Investigator

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Toward the total synthesis of novel anti-protozoal 12-membered macrolidesPrincipal Investigator

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Screening of Plasmodium falciparum enoyl-Acyl carrier protein reductase (PfFabI) inhibitors from microbial metabolites for prophylaxis and blocking transmission of malaria

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Total Synthesis of Naphthacemycins, Possession of Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)Principal Investigator

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Enantioselective total synthesis of(+)-Hydroxyapparicine, potent antimalarial indole alkaloid.Principal Investigator

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タイプIII分泌機構阻害活性に着目した抗感染症薬の創製Principal Investigator

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[Book] 月刊ファインケミカル2月号2014

Author(s)

Hirose Tomoyasu 廣瀬友靖

HIROSE Tomoyasu 廣瀬友靖

廣瀬友靖ヒロセトモヤス

[Book] クリックケミストリー　–基礎から実用まで-2014