Ito Naoki 伊藤直樹

… Alternative Names

ITO Naoki 伊藤直樹

Less

Researcher Number	00370164
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 北里大学, 薬学部, 講師 2021: 北里大学, 東洋医学総合研究所, 室長補佐 2017 – 2019: 北里大学, 東洋医学総合研究所, 上級研究員 2014 – 2018: 北里大学, 東洋医学総合研究所, 研究員 2011 – 2012: 北里大学, 東洋医学総合研究所, 研究員 … More 2009 – 2010: Kitasato University, 東洋医学総合研究所, 上級研究員 2008: Kitasato University, 東洋医学総合研究所, 研究員 2007: Kitasato Institute, 東洋医学総合研究所, 研究員 Less
Review Section/Research Field	Principal Investigator General internal medicine (including Psychosomatic medicine) / Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) Except Principal Investigator General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator 香蘇散 / うつ / 脳内炎症 / 漢方薬 / オレキシン / 社会的ストレス / 抗うつ様効果 / 抗うつ様作用メカニズム / うつ予防 / Microglia … More / ミクログリア / 未病制御 / うつ再発 / 再発 / 概日リズム / 不安 / 老化促進マウス / 未病評価モデル / 未病 / 再発うつ / マイクログリア / negative cognitive bias / 抑うつ / 再燃・再発 / Neuropeptide Y / Orexin A / neuropeptide Y / ニューロペプチド / 神経新生 … More Except Principal Investigator 薬理学 / 薬学 / プロテオーム / 脳・神経 / 安定同位体標識法 / プロテオーム解析 / 海馬 / マウスモデル / 社会的ストレス / うつ / 香蘇散 / 漢方薬 Less

漢方薬の脳内炎症抑制効果に関与する分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  伊藤直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kitasato University
Basic research on Kampo formula focusing on inhibition of neuroinflammation for preventive effects on depressionPrincipal Investigator
- Principal Investigator
  
  Ito Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kitasato University
Proteomic analysis of the mode of action of antidepressive-like effect of a Kampo (traditional Japanese) medicine "kososan" extract.
- Principal Investigator
  
  NAGAI Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kitasato University
Basic research for preventive effects of a Kampo medicine on social stress-induced recurrent depression and pre-symptomatic state for emotional disordersPrincipal Investigator
- Principal Investigator
  
  Ito Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kitasato University
Efficacy of kososan on social stress - basic research using multi-behavioral battery-Principal Investigator
- Principal Investigator
  
  Ito Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kitasato University
Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososanPrincipal Investigator
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.Principal Investigator
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
A possible mechanism underlying an antidepressive-like effect of kososan -A association of orexin-A with neurogenesis-Principal Investigator
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
  Kitasato Institute

[Journal Article] Kampo formulas alleviate aging‐related emotional disturbances and neuroinflammation in male senescence‐accelerated mouse prone 8 mice2022
- Author(s)
  Naoki Ito, Akiko Maruko, Kenshiro Oshima, Masaaki Yoshida, Kengo Honma, Chika Sugiyama, Takayuki Nagai, Yoshinori Kobayashi, Hiroshi Odaguchi, Norihiro Okada
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 14 (1) Issue: 1 Pages: 109-142
- DOI
  10.18632/aging.203811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07859, KAKENHI-PROJECT-21K07376
[Journal Article] Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.2018
- Author(s)
  Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ
- Journal Title
  
  Nature Medicine
  
  Volume: 24 Issue: 5 Pages: 658-666
- DOI
  10.1038/s41591-018-0002-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09319
[Journal Article] Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice2017
- Author(s)
  Ito Naoki、Hirose Eiji、Ishida Tatsuya、Hori Atsushi、Nagai Takayuki、Kobayashi Yoshinori、Kiyohara Hiroaki、Oikawa Tetsuro、Hanawa Toshihiko、Odaguchi Hiroshi
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 14 Issue: 1 Pages: 98-98
- DOI
  10.1186/s12974-017-0876-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09319, KAKENHI-PROJECT-17K09320
[Journal Article] Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice2012
- Author(s)
  Ito N., Hori A., Yabe T., Nagai T., Oikawa T., Yamada H. and Hanawa T
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35(10) Pages: 1775-1783
- NAID
  130001872380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790751
[Journal Article] Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice.2012
- Author(s)
  Naoki Ito
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 1775-1783
- NAID
  130001872380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790751
[Journal Article] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice.2009
- Author(s)
  Ito N., Yabe T., Nagai T., Oikawa T., Yamada H., Hanawa T.
- Journal Title
  
  Biol.Pharm.Bull. 32(10)
  
  Pages: 1716-1722
- NAID
  130000116932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790631
[Journal Article] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced Depression-like model mice.2009
- Author(s)
  Ito N., et al.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1716-1722
- NAID
  130000116932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790631
[Journal Article] I.c.v administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation2008
- Author(s)
  Ito N., et.al.
- Journal Title
  
  Neuroscience 157
  
  Pages: 720-732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790463
[Journal Article] administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation2008
- Author(s)
  Ito N., Yabe T., Gamo Y., Nagai T., Oikawa T., Yamada H. and Hanawa T., I.c.v.
- Journal Title
  
  Neuroscience 157
  
  Pages: 720-732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790463
[Presentation] LPS誘発sickness behaviorおよび脳内炎症に対するnobiletin高含有陳皮配合香蘇散の有効性2024
- Author(s)
  伊藤直樹、三木理恵子、河田直也、吉田雅昭、小林義典
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] 加齢性うつに対するN香蘇散の抑制効果と腸内細菌叢の関係性2023
- Author(s)
  三木理恵子、伊藤直樹、河田直也、定光祐佳、永井隆之、小田口浩、西山和利
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] LPS 誘発うつ様行動および炎症応答に対する N 香蘇散の抑制効果 -老化促進モデル SAMP8 マウスを用いた検討-2023
- Author(s)
  河田直也、伊藤直樹、三木理恵子、定光祐佳、永井隆之、佐藤俊哉、小田口浩
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] LPS誘発うつ様行動出現および脳微小血管内皮細胞の炎症応答に対するN香蘇散の抑制効果2023
- Author(s)
  河田直也、伊藤直樹、三木理恵子、佐藤俊哉、小林義典
- Organizer
  第40回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] ココロに効く漢方薬の薬効メカニズム解明への挑戦2023
- Author(s)
  伊藤直樹
- Organizer
  第58回日本東洋心身医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] 加齢性の脳内炎症に対する漢方薬の抑制メカニズムの解析2022
- Author(s)
  伊藤直樹、定光祐佳、三木理恵子、河田直也、永井隆之、花輪壽彦、小田口浩
- Organizer
  第 39 回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07376
[Presentation] うつ症状に対する漢方薬の再発予防効果および未病制御の基礎研究2020
- Author(s)
  伊藤直樹
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] うつ症状に対する漢方薬の再発予防効果および未病制御の基礎研究2020
- Author(s)
  伊藤直樹
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 安定同位体標識法とGeLC-MS/MS法を組み合わせたタンパク質存在様式の比較分析法の確立と応用2019
- Author(s)
  伊藤大晃、紺野　亮、福井朋也、松井　崇、長塩　亮、佐藤雄一、小寺義男
- Organizer
  日本プロテオーム学会2019年大会第70回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] SAMP8マウスを利用した未病評価モデルとしての可能性2019
- Author(s)
  伊藤直樹、竹元裕明、長谷川綾那、杉山千佳、藤田里奈、小口晴美、永井隆之、小林義典、清原寛章、及川哲郎、小田口浩
- Organizer
  第34回SAM学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] 老化促進マウスを用いた香蘇散の未病制御2019
- Author(s)
  伊藤直樹、長谷川綾那、杉山千佳、永井隆之、清原寛章、及川哲郎、小田口　浩
- Organizer
  第36回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 水中拘束ストレスマウスの大脳皮質を対象とした包括的なタンパク質存在様式の比較分析2019
- Author(s)
  紺野　亮、伊藤大晃、樋口雅崇、松井　崇、佐藤俊哉、板倉　誠、小寺義男
- Organizer
  日本プロテオーム学会2019年大会第70回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 老化促進マウスを用いた香蘇散の未病制御2019
- Author(s)
  伊藤直樹、長谷川綾那、杉山千佳、永井隆之、清原寛章、及川哲郎、小田口浩
- Organizer
  第36回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] ストレスおよび加齢モデル動物を用いた薬効および病態評価系～うつ症状に対する漢方薬の薬効解析～2018
- Author(s)
  伊藤直樹
- Organizer
  食・触コンソーシアム
- Invited
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] 漢方基本処方の揮発性成分の解析2018
- Author(s)
  大田黒晴樹、永井隆之、伊藤直樹、坂田幸治、緒方千秋、関根麻理子、若杉安希乃、小林義典、小田口　浩、清原寛章、平本忠浩
- Organizer
  第35回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 社会的ストレス誘発うつ様行動に対する漢方方剤「香蘇散」と抗うつ薬の併用による治療効果2018
- Author(s)
  伊藤直樹, 廣瀬栄治, 長谷川綾那, 永井隆之, 清原寛章, 及川哲郎, 小田口浩
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] 老化促進マウスを利用した未病動物モデルとしての可能性2018
- Author(s)
  伊藤直樹、竹元裕明、長谷川綾那、杉山千佳、永井隆之、小林義典、清原寛章、及川哲郎、小田口浩
- Organizer
  第35回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] 社会的ストレス誘発うつ様行動に対する漢方方剤「香蘇散」と抗うつ薬の併用による治療効果2018
- Author(s)
  伊藤直樹、廣瀬栄治、長谷川綾那、永井隆之、清原寛章、及川哲郎、小田口　浩
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 社会的敗北ストレスモデルでのうつ様行動の評価と香蘇散の作用の解析2018
- Author(s)
  長谷川綾那、伊藤直樹、紺野　亮、小寺義男、永井隆之、清原寛章
- Organizer
  天然薬物研究方法論アカデミー第21回研究集会（蒲郡シンポジウム）
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 漢方方剤「香蘇散」の社会的ストレス誘発うつ様行動の再発防止効果2017
- Author(s)
  伊藤直樹、廣瀬栄治、永井隆之、清原寛章、及川哲郎、小田口浩
- Organizer
  第34回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] 社会的ストレスによる抑うつ様行動の再発に対する漢方方剤「香蘇散」の防止効果2017
- Author(s)
  伊藤直樹、廣瀬栄治、永井隆之、清原寛章、及川哲郎、小田口浩
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台国際センター・東北大学（宮城県、仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460918
[Presentation] ストレス社会における漢方方剤の位置づけ -ストレスモデル動物を用いた基礎研究から見えてきた漢方方剤「香蘇散」の役割-2017
- Author(s)
  伊藤直樹
- Organizer
  日本生薬学会第64回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09320
[Presentation] ストレス誘発うつ様モデルマウスを用いた香蘇散揮発性成分の抗うつ様効果に関する解析2017
- Author(s)
  伊藤直樹
- Organizer
  第34回和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] ストレス社会における漢方方剤の位置づけ -ストレスモデル動物を用いた基礎研究から見えてきた漢方方剤「香蘇散」の役割-2017
- Author(s)
  伊藤直樹
- Organizer
  日本生薬学会第64回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 漢方方剤「香蘇散」の社会的ストレス誘発うつ様行動の再発防止効果2017
- Author(s)
  伊藤直樹、廣瀬栄治、永井隆之、清原寛章、及川哲郎、小田口　浩
- Organizer
  第34回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09319
[Presentation] 社会的ストレス誘発脳内炎症に対する香蘇散の制御2016
- Author(s)
  伊藤直樹、廣瀬栄治、石田達哉、堀厚、永井隆之、小林義典、清原寛章、及川哲郎、花輪壽彦、小田口浩
- Organizer
  第33回和漢医薬学会学術大会
- Place of Presentation
  星薬科大学 (東京都、品川区)
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-26460918
[Presentation] 漢方方剤「香蘇散」による社会的ストレス誘発うつ様行動緩和には、脳内炎症反応抑制が関与する2016
- Author(s)
  伊藤直樹、廣瀬栄治、石田達哉、堀厚、永井隆之、小林義典、清原寛章、及川哲郎、花輪壽彦、小田口浩
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26460918
[Presentation] 社会性ストレス誘発うつ様行動とそれに伴う脳内炎症反応に対する香蘇散の抑制効果2015
- Author(s)
  伊藤直樹、廣瀬栄治、石田達哉、堀厚、永井隆之、小林義典、清原寛章、及川哲郎、花輪壽彦
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山国際会議場（富山県、富山市）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26460918
[Presentation] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, through the hypothalamic orexinergic system in the stress-induced depression-like model mice2012
- Author(s)
  Ito N
- Organizer
  1st Joint Symposium between WHO Collaborating Centres for Traditional Medicine in Korea and Japan
- Place of Presentation
  Tokyo
- Year and Date
  2012-09-01
- Data Source
  KAKENHI-PROJECT-23790751
[Presentation] 香蘇散の抗うつ様効果における脳内 orexin A/neuropeptide Y 神経系の関与2012
- Author(s)
  伊藤直樹
- Organizer
  第29回和漢医薬学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790751
[Presentation] 香蘇散の抗うつ様効果における脳内 neuropeptide Y 神経系の関与2011
- Author(s)
  伊藤直樹
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23790751
[Presentation] Intracerebroventricular injection of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.2010
- Author(s)
  Ito N.
- Organizer
  Neuroscience 2010, SfN's 40th annual meeting
- Place of Presentation
  San Diego.
- Data Source
  KAKENHI-PROJECT-21790631
[Presentation] 香蘇散の抗うつ様効果におけるオレキシン神経系の関与2009
- Author(s)
  伊藤直樹
- Organizer
  第26回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21790631
[Presentation] 香蘇散の抗うつ様効果におけるオレキシン神経系の関与2009
- Author(s)
  伊藤直樹, 他
- Organizer
  第26回和漢医薬学会学術大会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-21790631
[Presentation] Orexin Aの抗うつ様作用メカニズムの解析-Neuropeptide Y の関与-2008
- Author(s)
  伊藤直樹
- Organizer
  第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
- Place of Presentation
  品川
- Data Source
  KAKENHI-PROJECT-19790463
[Presentation] Orexin Aの抗うつ様作用メカニズムの解析-Neuropeptide Yの関与-2008
- Author(s)
  伊藤直樹
- Organizer
  第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
- Place of Presentation
  品川
- Data Source
  KAKENHI-PROJECT-19790463
[Presentation] Orexin A脳室内投与の神経幹細胞挙動及びマウス行動に与える影響2007
- Author(s)
  伊藤直樹
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19790463
[Presentation] 社会的ストレスに対する香蘇散の有効性
- Author(s)
  伊藤直樹、堀厚、及川哲郎、花輪壽彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460918

1. HANAWA Toshihiko (40164892)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. OIKAWA Tetsuro (10370165)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. NAGAI Takayuki (00172487)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. YAMADA Haruki (60096691)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. YABE Takeshi (40239835)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. 小寺義男 (60265733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Ito Naoki 伊藤 直樹

ITO Naoki 伊藤 直樹

Research Projects

Research Products

Co-Researchers

漢方薬の脳内炎症抑制効果に関与する分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research on Kampo formula focusing on inhibition of neuroinflammation for preventive effects on depressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proteomic analysis of the mode of action of antidepressive-like effect of a Kampo (traditional Japanese) medicine "kososan" extract.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research for preventive effects of a Kampo medicine on social stress-induced recurrent depression and pre-symptomatic state for emotional disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Efficacy of kososan on social stress - basic research using multi-behavioral battery-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A possible mechanism underlying an antidepressive-like effect of kososan -A association of orexin-A with neurogenesis-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Kampo formulas alleviate aging‐related emotional disturbances and neuroinflammation in male senescence‐accelerated mouse prone 8 mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice.2009

Author(s)

Ito Naoki 伊藤直樹

ITO Naoki 伊藤直樹