Igawa Ken 井川健

… Alternative Names

井川健イガワケン

IGAWA Ken 井川健

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Researcher Number	00372441
Other IDs
Affiliation (Current)	2025: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 獨協医科大学, 医学部, 教授 2017: 獨協医科大学, 医学部, 教授 2016: 東京医科歯科大学, 医歯学総合病院, 准教授 2015 – 2016: 東京医科歯科大学, 医学部附属病院, 准教授 2015: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 … More 2012 – 2014: 東京医科歯科大学, 医学部附属病院, 講師 2010: Osaka University, 医学系研究科, 講師 2009: Tokyo Medical and Dental University, 医学部附属病院, 講師 2006: 東京医科歯科大学, 大学院医歯薬学総合研究科, 助手 2004 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related
Keywords	Principal Investigator アトピー性皮膚炎 / ゲノム編集 / ヒト / 角化細胞 / フィラグリン / 人工ヌクレアーゼ / iPS細胞 / アレルギー / 表皮角化細胞 / 病態解明 … More / MAIT細胞 / 病態形成機序 / マウスモデル / K14 / TALEN / 人工多能性幹細胞 / フィラグリン遺伝子 / ケラチン遺伝子 / ヒトiPS細胞 / TALENs / Cas9/CRISPR / 接触過敏反応 / RNA干渉 / 治療 / STAT6 / 好酸球 / IgE / ケモカイン … More Except Principal Investigator iPS細胞 / 血管型エーラス・ダンロス症候群 / ドミナントネガティブ効果 / COL3A1 / 3型コラーゲン / SNP / siRNA / エーラス・ダンロス症候群 / CD34 / 線維芽細胞 / ガドリニウムイオン / 腎性全身性線維症 / 細胞増殖 / リプログラミング / ガドテル酸メグルミン / ガドジアミド / ガドリニウム造影剤 / ガドリニウム / トiPS細胞 / ブルーム遺伝子 / Loss Of Heterozygosity / 相同組換え / CRISPR/Cas9 / 遺伝性皮膚疾患 / revertant mosaicism / 膠原病 / モデルマウス / 脱毛症 / アトピー性皮膚炎 / トランスジェニックマウス / CD40リガンド / 表皮角化細胞 / 人工ヌクレアーゼ / ヒト / ＩｇＥ / ＴＨ２サイトカイン / 蕁麻疹 / プロテアーゼ / IgE / STAT6 / M2マクロファージ / TH2サイトカイン / 痒疹 / 好塩基球 Less

siRNAによる血管型エーラス・ダンロス症候群の新規治療開発を目指したin vitro研究
- Principal Investigator
  
  林周次郎
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Dokkyo Medical University
アトピー性皮膚炎におけるMAIT細胞の役割を明らかにするPrincipal Investigator
- Principal Investigator
  
  井川健
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Dokkyo Medical University
Potential reprogramming of skin fibroblasts by gadolinium stimulation
- Principal Investigator
  
  Hayashi Shujiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Dokkyo Medical University
Examination of 'true' meanings of filaggrin mutation in human epidermal keratinocytes.Principal Investigator
- Principal Investigator
  
  IGAWA KEN
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Dokkyo Medical University
  Tokyo Medical and Dental University
Analysis of cutaneous lesion in collagen disease induced by intranuclear autoantibody.
- Principal Investigator
  
  HIGUCHI Tetsuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
Establishments of the new forward genetic method using homologues recombination in human iPS cells
- Principal Investigator
  
  Yoshimura Yasuhide
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Osaka University
An establishment of novel treatment based for the pathogenesis of untreated allergic skin diseases
- Principal Investigator
  
  Yokozeki Hiroo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tokyo Medical and Dental University
induction from fibroblast to keratinocyte
- Principal Investigator
  
  SATO HITOMI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Dokkyo Medical University
A trial for the clarification of the precise relationship between filaggrin gene mutation and atopic dermatitis by using human pluripotent stem cellPrincipal Investigator
- Principal Investigator
  
  IGAWA Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tokyo Medical and Dental University
Approaches of the new therapy development for atopic dermatitis by using RNA interferencePrincipal Investigator
- Principal Investigator
  
  IGAWA Ken
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Osaka University
  Tokyo Medical and Dental University
アトピー性皮膚炎由来の表皮角化細胞における転写調節因子の解析Principal Investigator
- Principal Investigator
  
  井川健
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Tokyo Medical and Dental University

All 2023 2019 2018 2016 2015 2014 2013 2012 2011 2010 2009 2006

All Journal Article Presentation

[Journal Article] Clinical features and morphology of collagen fibrils in patients with vascular Ehlers?Danlos based on electron microscopy2023
- Author(s)
  Ishikawa Satoko、Hayashi Shujiro、Sairenchi Toshimi、Miyamoto Manabu、Yoshihara Shigemi、Kobashi Gen、Yamaguchi Tomomi、Kosho Tomoki、Igawa Ken
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 14
- DOI
  10.3389/fgene.2023.1238209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07773
[Journal Article] Case report: Mild phenotype of a patient with vascular Ehlers?Danlos syndrome and COL3A1 duplication mutation without alteration in the [Gly-X-Y] repeat sequence2023
- Author(s)
  Hayashi Shujiro、Yamaguchi Tomomi、Kosho Tomoki、Igawa Ken
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 13
- DOI
  10.3389/fgene.2022.1017446
- Data Source
  KAKENHI-PROJECT-23K07773
[Journal Article] Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells2014
- Author(s)
  Ken Igawaa, Chikara Kokubu, Kosuke Yusa, Kyoji Horie, Yasuhide Yoshimura, Kaori Yamauchi, Hirofumi Suemori, Hiroo Yokozeki, Masashi Toyoda, Nobutaka Kiyokawa, Hajime Okita, Yoshitaka Miyagawa, Hidenori Akutsu, Akihiro Umezawa, Ichiro Katayama, Junji Takeda.
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 3 Issue: 9 Pages: 992-1001
- DOI
  10.5966/sctm.2013-0179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22310118, KAKENHI-PROJECT-24591651, KAKENHI-PROJECT-24615003, KAKENHI-PROJECT-25461665, KAKENHI-PROJECT-25640048, KAKENHI-PROJECT-24241064
[Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hyper sensitivity and allergic rhinitis.2011
- Author(s)
  Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K, et al
- Journal Title
  
  Allegy
  
  Volume: 66(1) Pages: 124-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791064
[Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis.2011
- Author(s)
  Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K(10人中5番目)
- Journal Title
  
  Allegy 66(1)
  
  Pages: 124-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791064
[Journal Article] 【アトピー性皮膚炎の正しい治療】アトピー性皮膚炎の新しい治療の展望2010
- Author(s)
  井川健
- Journal Title
  
  医薬ジャーナル 46(3)
  
  Pages: 994-998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791064
[Journal Article] Regulatory mechanisms of galectin-9 and eotaxin-3 synthesis in epidermal keratinocytes : possible involvement of galectin-9 in dermal eosinophilia of Th1-polarized skin inflammation.2006
- Author(s)
  Igawa K, et al.
- Journal Title
  
  Allergy 61(12)
  
  Pages: 1385-1385
- Data Source
  KAKENHI-PROJECT-16790625
[Presentation] Anti-inflammatory effects of potassium iodide in sodium dodecyl sulphate-induced inflammatory murine skin through interleukin-10 regulation.2019
- Author(s)
  Shujiro Hayashi. Satoko Ishikawa, Masami Koike, Tomoko Kaminaga, Yoichiro Hamasaki, Ken Igawa.
- Organizer
  49th Annual ESDR Meeting. Bordeaux, 2019. 9.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08799
[Presentation] iPS細胞の基礎と臨床2018
- Author(s)
  井川　健
- Organizer
  第117回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09759
[Presentation] To clarify the effect of the filaggrin gene mutation in keratinocytes by using CRISPR/Cas9 system and human induced pluripotent stem cells.2016
- Author(s)
  Ken Igawa
- Organizer
  The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Sendai, Japan
- Year and Date
  2016-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09759
[Presentation] REMOVAL OF REPROGRAMMING TRANSGENES IMPROVES THE TISSUE RECONSTITUTION POTENTIAL OF KERATINOCYTES GENERATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS.2015
- Author(s)
  Igawa K. et al.
- Organizer
  23rd World Congress of Dermatology 2015
- Place of Presentation
  Vancouver（Canada）
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461665
[Presentation] A trial to clarify the effect of the filaggrin gene mutation to keratinocytes biology by using CRISPR/Cas9 system and human induced pluripotent stem cells.2015
- Author(s)
  Igawa K. et al.
- Organizer
  ESDR2015
- Place of Presentation
  Rotterdam（Netherlands）
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461665
[Presentation] A trial to clarify the effect of the filaggrin gene mutation to keratinocytes biology by using CRISPR/Cas9 system and human induced pluripotent stem cells.2015
- Author(s)
  Igawa K
- Organizer
  European Society for Dermatological Research 2015
- Place of Presentation
  ロッテルダム、オランダ
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09759
[Presentation] REMOVAL OF REPROGRAMMING TRANSGENES IMPROVES THE TISSUE RECONSTITUTION POTENTIAL OF KERATINOCYTES GENERATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS.2015
- Author(s)
  Igawa K
- Organizer
  World Congress of Dermatology 2015
- Place of Presentation
  バンクーバー、カナダ
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09759
[Presentation] アトピー性皮膚炎の病型と難治性皮膚病変の関連に関する疫学調査2014
- Author(s)
  野老翔雲、井川　健、戸倉新樹、宮地良樹、片山一朗、佐藤貴浩、横関博雄
- Organizer
  第２６回日本アレルギー学会春季臨床大会
- Place of Presentation
  京都市
- Year and Date
  2014-05-09
- Data Source
  KAKENHI-PROJECT-25461665
[Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line: Implication for therapeutic application.2013
- Author(s)
  Igawa K
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Edinburgh, Scotland
- Data Source
  KAKENHI-PROJECT-24591651
[Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line: Implication for therapeutic application.2013
- Author(s)
  井川　健
- Organizer
  第8回　箱根カンファレンス
- Place of Presentation
  淡路島
- Invited
- Data Source
  KAKENHI-PROJECT-24591651
[Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line:Implication for therapeutic application.2013
- Author(s)
  IGAWA K.
- Organizer
  第8回　箱根カンファレンス
- Place of Presentation
  兵庫県淡路島淡路夢舞台
- Data Source
  KAKENHI-PROJECT-25461665
[Presentation] Efficient keratinocytes differentiation from transgene-free human induced pluripotent stem cell line.2013
- Author(s)
  IGAWA K., HORIE K., YUSA K., YOKOZEKI H., KATAYAMA I., TAKEDA. J.
- Organizer
  Implication for therapeutic application. International Investigative Dermatology.
- Place of Presentation
  Edinburgh, Scotland
- Data Source
  KAKENHI-PROJECT-25461665
[Presentation] induced keratinocytes from transgene-free but not transgene-residual human induced pluripotent stem cells phenotypically resemble primary human keratinocytes.2012
- Author(s)
  Ken IGAWA, Kyoji HORIE, Hiroo YOKOZEKI, Ichiro KATAYAMA, Junji TAKEDA.
- Organizer
  The 42nd Annual Meeting of the European Society for Dermatological Research
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-24591651
[Presentation] A trial of in vitro reconstitution of human skin using transgene-free induced pluripotent stem cells.2012
- Author(s)
  Ken IGAWA, Kyoji HORIE, Kosuke YUSA, Junji TAKEDA, Ichiro KATAYAMA
- Organizer
  10th annual meeting of ISSCR
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-24591651
[Presentation] 重症アトピー性皮膚炎の新規治療2010
- Author(s)
  井川健
- Organizer
  第109回日本皮膚科学会総会教育講演
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-21791064
[Presentation] 重症アトピー性皮膚炎の新規治療2010
- Author(s)
  井川健
- Organizer
  第109回日本皮膚科学会総会教育講演
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21791064
[Presentation] A therapeutic effect of STAT6 inhibition in atopic dermatitis2009
- Author(s)
  Ken Igawa
- Organizer
  Yonsei Cutaneous Biology Research Institute International Symposium 2009
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21791064
[Presentation] A therapeutic effect of ST AT6 inhibition in atopic dermatitis.2009
- Author(s)
  Igawa K
- Organizer
  Yonsei Cutaneous Biology Research Institute International Symposium 2009
- Place of Presentation
  Seoul(招待講演)
- Data Source
  KAKENHI-PROJECT-21791064

1. Hayashi Shujiro (00599871)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Yokozeki Hiroo (90210608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SATO HITOMI (00648090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HIGUCHI Tetsuya (00334425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUBATA Takeshi (80197756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Yoshimura Yasuhide (60263307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宇賀神つかさ (40581327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 堀江恭二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Igawa Ken 井川 健

井川 健 イガワ ケン

IGAWA Ken 井川 健

Research Projects

Research Products

Co-Researchers

siRNAによる血管型エーラス・ダンロス症候群の新規治療開発を目指したin vitro研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アトピー性皮膚炎におけるMAIT細胞の役割を明らかにするPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Potential reprogramming of skin fibroblasts by gadolinium stimulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examination of 'true' meanings of filaggrin mutation in human epidermal keratinocytes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cutaneous lesion in collagen disease induced by intranuclear autoantibody.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishments of the new forward genetic method using homologues recombination in human iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An establishment of novel treatment based for the pathogenesis of untreated allergic skin diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

induction from fibroblast to keratinocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A trial for the clarification of the precise relationship between filaggrin gene mutation and atopic dermatitis by using human pluripotent stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approaches of the new therapy development for atopic dermatitis by using RNA interferencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アトピー性皮膚炎由来の表皮角化細胞における転写調節因子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical features and morphology of collagen fibrils in patients with vascular Ehlers?Danlos based on electron microscopy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Case report: Mild phenotype of a patient with vascular Ehlers?Danlos syndrome and COL3A1 duplication mutation without alteration in the [Gly-X-Y] repeat sequence2023

Author(s)

Journal Title

Igawa Ken 井川健

井川健イガワケン

IGAWA Ken 井川健

[Presentation] アトピー性皮膚炎の病型と難治性皮膚病変の関連に関する疫学調査2014